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https://www.readbyqxmd.com/read/28636876/tissue-alignment-enhances-remodeling-potential-of-tendon-derived-cells-lessons-from-a-novel-microtissue-model-of-tendon-scarring
#1
Jasper Foolen, Stefania L Wunderli, Sandra Loerakker, Jess G Snedeker
Tendinopathy is a widespread and unresolved clinical challenge, in which associated pain and hampered mobility present a major cause for work-related disability. Tendinopathy associates with a change from a healthy tissue with aligned extracellular matrix (ECM) and highly polarized cells that are connected head-to-tail, towards a diseased tissue with a disorganized ECM and randomly distributed cells, scar-like features that are commonly attributed to poor innate regenerative capacity of the tissue. A fundamental clinical dilemma with this scarring process is whether treatment strategies should focus on healing the affected (disorganized) tissue or strengthen the remaining healthy (anisotropic) tissue...
June 18, 2017: Matrix Biology: Journal of the International Society for Matrix Biology
https://www.readbyqxmd.com/read/28636528/three-dimensional-reconstruction-of-energy-stores-for-jumping-in-planthoppers-and-froghoppers-from-confocal-laser-scanning-microscopy
#2
Igor Siwanowicz, Malcolm Burrows
Jumping in planthopper and froghopper insects is propelled by a catapult-like mechanism requiring mechanical storage of energy and its quick release to accelerate the hind legs rapidly. To understand the functional biomechanics involved in these challenging movements, the internal skeleton, tendons and muscles involved were reconstructed in 3-D from confocal scans in unprecedented detail. Energy to power jumping was generated by slow contractions of hind leg depressor muscles and then stored by bending specialised elements of the thoracic skeleton that are composites of the rubbery protein resilin sandwiched between layers of harder cuticle with air-filled tunnels reducing mass...
June 21, 2017: ELife
https://www.readbyqxmd.com/read/28636440/effects-of-time-to-start-training-after-acute-patellar-tendon-enthesis-injuries-on-healing-of-the-injury-in-a-rabbit-model
#3
Lin Wang, Kaiyu Xiong, Bo Wang, Xiaotian Liang, Haiwei Li, Haitao Liu, Hui He
BACKGROUND: A patellar tendon injury is a common injury in sports. The optimal time to start training after an acute, proximal patellar enthesis injury is still unclear. HYPOTHESIS: The time to start training after an acute, proximal patellar enthesis injury significantly affects healing of the patellar tendon 4 weeks after the injury. STUDY DESIGN: Controlled laboratory study. METHODS: The left hindlimbs of 35 mature female rabbits were randomly assigned to 5 injury groups including a 4-week natural healing group (NH4W) and 4 training groups that started low-intensity training at 24 hours (POST24), 48 hours (POST48), 72 hours (POST72), and 96 hours (POST96) after an acute patellar tendon injury, with 7 limbs in each group...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28636429/autograft-versus-allograft-for-posterior-cruciate-ligament-reconstruction-an-updated-systematic-review-and-meta-analysis
#4
John W Belk, Matthew J Kraeutler, Justin M Purcell, Eric C McCarty
BACKGROUND: Multiple studies have demonstrated a higher risk of graft failure after anterior cruciate ligament reconstruction with allograft, but limited data are available comparing outcomes of posterior cruciate ligament reconstruction (PCLR) with autograft versus allograft. PURPOSE: To compare the clinical outcomes of autograft versus allograft for primary PCLR. STUDY DESIGN: Systematic review. METHODS: A systematic review was performed by searching PubMed, the Cochrane Library, and EMBASE to locate studies (level of evidence I-III) comparing clinical outcomes of autograft versus allograft in patients undergoing primary PCLR with the conventional transtibial technique...
June 1, 2017: American Journal of Sports Medicine
https://www.readbyqxmd.com/read/28635316/complications-following-collagenase-treatment-for-dupuytren-contracture
#5
Jennifer Wozniczka, Clifford Canepa, Adam Mirarchi, Joel S Solomon
BACKGROUND: Collagenase Clostridium histolyticum (CCH) injection and manipulation is a relatively new method for treating Dupuytren contracture that is growing in popularity. Although side effects such as swelling and ecchymosis are common, they are typically mild and self-limited. Major complications are rare but have included flexor tendon rupture and complex regional pain syndrome. METHODS: This study describes a case report of 2 patients seen at our institution...
June 1, 2017: Hand: Official Journal of the American Association for Hand Surgery
https://www.readbyqxmd.com/read/28635148/how-common-are-cranial-sesamoids-among-squamates
#6
Ricardo Montero, Juan D Daza, Aaron M Bauer, Virginia Abdala
Sesamoids are elements that originate as intratendinous structures due to genetic and epigenetic factors. These elements have been reported frequently in vertebrates, although cranial sesamoids have been recorded almost exclusively in non-tetrapod Osteichthyes. The only tetrapod cranial sesamoids reported until now have been the transiliens cartilage (of crocodiles and turtles), and another one located in the quadrate-mandibular joint of birds. Here, we examined seven squamate species using histological sections, dissections of preserved specimens, dry skeletons, cleared and stained specimens, computed tomographies (CT), and report the presence of other cranial sesamoids...
June 20, 2017: Journal of Morphology
https://www.readbyqxmd.com/read/28634854/micrornas-associated-with-inflammation-in-shoulder-tendinopathy-and-glenohumeral-arthritis
#7
Finosh G Thankam, Chandra S Boosani, Matthew F Dilisio, Devendra K Agrawal
Inflammation is associated with glenohumeral arthritis and rotator cuff tendon tears. Epigenetically, miRNAs tightly regulate various genes involved in the inflammatory response. Alterations in the expression profile of miRNAs and the elucidation of their target genes with respect to the pathophysiology could improve the understanding of their regulatory role and therapeutic potential. Here, we screened key miRNAs that mediate inflammation and linked with JAK2/STAT3 pathway with respect to the coincidence of glenohumeral arthritis in patients suffering from rotator cuff injury (RCI)...
June 20, 2017: Molecular and Cellular Biochemistry
https://www.readbyqxmd.com/read/28633798/case-report-irreducible-ankle-fracture-with-posterior-tibialis-tendon-and-retinaculum-deltoid-ligament-and-anteromedial-joint-capsule-entrapment
#8
Nicole M Stevens, Amy S Wasterlain, Sanjit R Konda
Irreducible ankle fractures are a relatively rare phenomenon. We present a case of a pronation abduction-type ankle fracture that was irreducible in the emergency room despite sedation. The patient was taken to the operating room, where the posterior tibialis tendon and retinaculum, deltoid ligament, and anteromedial capsule were found to be trapped within the joint. After removal of the tissue, alignment was restored. The patient did well clinically and was advanced to full weightbearing at 6 weeks. This is, to the best of our knowledge, the first report of entrapment of all 4 anatomic structures, preventing closed reduction...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633791/peroneus-tertius-tendon-tear-causing-lateral-ankle-pain-in-a-child
#9
Niall P McGoldrick, Diane Bergin, Stephen R Kearns
The peroneus tertius muscle arises in the anterior compartment of the leg and demonstrates significant morphologic variation. Its function is not yet clearly delineated. We present the case of a 12-year-old patient with an isolated tear of the peroneus tertius tendon that resulted in lateral based ankle pain. After surgical reconstruction, the patient's pain resolved, and he was able to return to his normal activities.
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633785/the-lisfranc-amputation-a-more-reliable-level-of-amputation-with-proper-intraoperative-tendon-balancing
#10
Christopher J Greene, Christopher Bibbo
Traditional transmetatarsal amputations are a reliable level of amputation. However, amputations at the Lisfranc level have met with limited success owing to improper biomechanics resulting from tendon imbalance, ultimately leading to foot deformity positions and an unstable soft tissue envelope with ensuing skin breakdown, infection, and below-the-knee amputation. We describe proper tendon rebalancing that results in improved biomechanics and a more reliable and stable amputation at the more proximal Lisfranc level...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633783/a-biomechanical-analysis-of-interference-screw-versus-bone-tunnel-fixation-of-flexor-hallucis-longus-tendon-transfers-to-the-calcaneus
#11
George T Liu, B Christian Balldin, Jacob R Zide, Christopher T Chen
The flexor hallucis longus tendon transfer is commonly used to restore function in chronic Achilles tendon ruptures and chronic Achilles tendinopathy. The tendon is often secured to the calcaneus either through a bone tunnel or by an interference screw. We hypothesized that tenodesis using the bone tunnel method would be mechanically superior to interference screw fixation for flexor hallucis longus transfers. Eight matched pairs of cadaveric specimens were assigned randomly to the bone tunnel or interference screw technique and were loaded to failure...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28633121/biomaterials-based-strategies-for-rotator-cuff-repair
#12
REVIEW
Song Zhao, Wei Su, Vishva Shah, Divia Hobson, Lara Yildirimer, Kelvin W K Yeung, Jinzhong Zhao, Wenguo Cui, Xin Zhao
Tearing of the rotator cuff commonly occurs as among one of the most frequently experienced tendon disorders. While treatment typically involves surgical repair, failure rates to achieve or sustain healing range from 20 to 90%. The insufficient capacity to recover damaged tendon to heal to the bone, especially at the enthesis, is primarily responsible for the failure rates reported. Various types of biomaterials with special structures have been developed to improve tendon-bone healing and tendon regeneration, and have received considerable attention for replacement, reconstruction, or reinforcement of tendon defects...
June 6, 2017: Colloids and Surfaces. B, Biointerfaces
https://www.readbyqxmd.com/read/28632507/tibialis-posterior-tenosynovitis-a-unique-musculoskeletal-manifestation-of-gout
#13
Peter Shupper, Todd P Stitik
Extra-articular manifestations of gout can present in several ways, including tenosynovitis. We present a rare case of acute tibialis posterior gouty tenosynovitis. An 82-year-old man with a history of well-controlled gout presented with acute onset of left ankle pain, occurring without inciting event. The medial ankle was slightly erythematous with moderate dorsal-medial swelling and mild dorsal-lateral swelling, with severe tenderness to palpation over the medial retro-malleolar region. Range of motion and manual muscle testing were pain limited throughout...
June 20, 2017: American Journal of Physical Medicine & Rehabilitation
https://www.readbyqxmd.com/read/28632290/a-single-incision-technique-for-distal-biceps-repair-using-a-flexible-reamer
#14
Todd P Pierce, Casey M Pierce, Kimona Issa, Vincent K McInerney, Anthony Festa, Anthony J Scillia
Distal biceps tendon ruptures are rare injuries that usually occur in middle-aged men. Most of these injuries are repaired acutely to restore preinjury function and strength. There is concern regarding the higher prevalence of certain complications with the double-incision technique. As such, the single-incision technique has also been studied to determine if it may produce superior safety and efficacy. In addition, the point of fixation may be created with either a rigid or a flexible reamer. The authors describe a technique that uses a single-incision cortical fixation achieved with a flexible reamer...
June 20, 2017: Orthopedics
https://www.readbyqxmd.com/read/28631375/3d-mimicry-of-native-tissue-fiber-architecture-guides-tendon-derived-cells-and-adipose-stem-cells-into-artificial-tendon-constructs
#15
Mariana Laranjeira, Rui M A Domingues, Raquel Costa-Almeida, Rui L Reis, Manuela E Gomes
Tendon and ligament (T/L) function is intrinsically related with their unique hierarchically and anisotropically organized extracellular matrix. Their natural healing capacity is, however, limited. Here, continuous and aligned electrospun nanofiber threads (CANT) based on synthetic/natural polymer blends mechanically reinforced with cellulose nanocrystals are produced to replicate the nanoscale collagen fibrils grouped into microscale collagen fibers that compose the native T/L. CANT are then incrementally assembled into 3D hierarchical scaffolds, resulting in woven constructions, which simultaneously mimic T/L nano-to-macro architecture, nanotopography, and nonlinear biomechanical behavior...
June 20, 2017: Small
https://www.readbyqxmd.com/read/28631261/distinct-post-translational-features-of-type-i-collagen-are-conserved-in-mouse-and-human-periodontal-ligament
#16
D M Hudson, M Garibov, D R Dixon, T Popowics, D R Eyre
BACKGROUND AND OBJECTIVE: Specifics of the biochemical pathways that modulate collagen cross-links in the periodontal ligament (PDL) are not fully defined. Better knowledge of the collagen post-translational modifications that give PDL its distinct tissue properties is needed to understand the pathogenic mechanisms of human PDL destruction in periodontal disease. In this study, the post-translational phenotypes of human and mouse PDL type I collagen were surveyed using mass spectrometry...
June 20, 2017: Journal of Periodontal Research
https://www.readbyqxmd.com/read/28631112/risk-of-revision-was-not-reduced-by-a-double-bundle-acl-reconstruction-technique-results-from-the-scandinavian-registers
#17
Cathrine Aga, Jüri-Tomas Kartus, Martin Lind, Stein Håkon Låstad Lygre, Lars-Petter Granan, Lars Engebretsen
BACKGROUND: Double-bundle anterior cruciate ligament (ACL) reconstruction has demonstrated improved biomechanical properties and moderately better objective outcomes compared with single-bundle reconstructions. This could make an impact on the rerupture rate and reduce the risk of revisions in patients undergoing double-bundle ACL reconstruction compared with patients reconstructed with a traditional single-bundle technique. The National Knee Ligament Registers in Scandinavia provide information that can be used to evaluate the revision outcome after ACL reconstructions...
June 19, 2017: Clinical Orthopaedics and related Research
https://www.readbyqxmd.com/read/28630840/suspension-arthroplasty-combined-with-ligament-reconstruction-of-the-thumb-carpometacarpal-joint-to-salvage-two-failed-arthroplasties-a-case-report
#18
Ryosuke Kakinoki, Kazuhiko Hashimoto, Hiroki Tanaka, Masao Akagi
INTRODUCTION: Thumb basal joint arthroplasty with removal of the entire trapezium is often followed by proximal subsidence and impingement of the thumb metacarpal to the scaphoid, which is a common cause of post-operative thumb pain. Treatment of this impingement is a challenge among surgeons. We performed suspension arthroplasty combined with intercarpal ligament reconstruction using a strip of the extensor carpi radialis longus (ECRL) tendon on a patient suffering from pain caused by this type of the impingement and obtained a successful outcome...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630835/intra-articular-fibroma-of-tendon-sheath-in-knee-joint-associated-with-iliotibial-band-friction-syndrome-rare-occurrence-in-a-teenage-girl
#19
Sameer Rathore, Vasil Quadri, Sanjay Tapadia, K Krishnaiah, V P Nithin Krishna
INTRODUCTION: Iliotibial band (ITB) friction syndrome is a common overuse injury typically seen in active athlete population. A nodular lesion on the inner side of the ITB as an etiology or an accompanying lesion with friction syndrome has rarely been reported. Among such nodular lesions around knee, fibroma of tendon sheath (FTS) is a rare occurrence. All the more intra-articular occurrence is extremely rare. CASE REPORT: A 16-year-old female presented with recurrent pain and movable nodule at the lateral joint area, diagnosed as ITB friction syndrome...
January 2017: Journal of Orthopaedic Case Reports
https://www.readbyqxmd.com/read/28630760/treatment-of-hindfoot-and-ankle-pathologies-with-posterior-arthroscopic-techniques
#20
Tahir Ögüt, N Selcuk Yontar
The two-portal hindfoot arthroscopy is an effective procedure enabling direct visualisation of posterior ankle pathology with low invasiveness.An important stage of the hindfoot endoscopy is localisation of the flexor hallucis longus (FHL) tendon to protect the neurovascular bundle which is located just medial to it.Posterior ankle impingement syndrome and FHL tenosynovitis are common causes of posterior ankle pain and frequently occur together.Posteriorly localised talar osteochondral lesions, Achilles tendon disorders, osteoarthritis, talar bone cysts and talar fractures are among the other pathologies that can be treated with hindfoot arthroscopy...
May 2017: EFORT open reviews
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