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https://www.readbyqxmd.com/read/27829814/quinoline-based-furanones-and-their-nitrogen-analogues-docking-synthesis-and-biological-evaluation
#1
Sukhbir Lal Khokra, Jyoti, Chetan, Pawan Kaushik, M M Alam, M S Zaman, Aftab Ahmad, Shah Alam Khan, Asif Husain
A small library of twenty-four quinoline based butenolides also known as furanones and their nitrogen analogues was prepared by using two different aroylpropionic acids, viz. 3-(2-naphthoyl)propionic acid (3) and 3-(biphenyl-4-yl)propionic acid (4), as starting materials. The 3-aroylpropionic acids were reacted with different 6-substituted-2-chloroquinolin-3-carbaldehydes (2a-d) to obtain the corresponding furan-2(3H)-ones (5a-h). The purified and characterized furanones were then converted into their corresponding 2(3H)-pyrrolones (6a-h) and N-benzyl-pyrrol-2(3H)-ones (7a-h)...
November 2016: Saudi Pharmaceutical Journal: SPJ: the Official Publication of the Saudi Pharmaceutical Society
https://www.readbyqxmd.com/read/27501304/preoperative-analgesics-for-additional-pain-relief-in-children-and-adolescents-having-dental-treatment
#2
REVIEW
Paul F Ashley, Susan Parekh, David R Moles, Prabhleen Anand, Laura C I MacDonald
BACKGROUND: Fear of dental pain is a major barrier to treatment for children who need dental care. The use of preoperative analgesics has the potential to reduce postoperative discomfort and intraoperative pain. We reviewed the available evidence to determine whether further research is warranted and to inform the development of prescribing guidelines. This is an update of a Cochrane review published in 2012. OBJECTIVES: To assess the effects of preoperative analgesics for intraoperative or postoperative pain relief (or both) in children and adolescents undergoing dental treatment without general anaesthesia or sedation...
August 8, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27240869/identifying-and-managing-pain-in-people-with-alzheimer-s-disease-and-other-types-of-dementia-a-systematic-review
#3
REVIEW
Bettina S Husebo, Wilco Achterberg, Elisabeth Flo
BACKGROUND AND OBJECTIVE: Pain in patients with Alzheimer's disease is a complex issue; these patients suffer from the common causes of acute and chronic pain, and some also have neuropathic or nociceptive pain. Whatever the mechanism of pain in these patients, their pain will require careful assessment and management, to insure the correct type and level of analgesia is given. The objective of this systematic review was the identification of studies that have investigated the efficacy of different analgesics on pain intensity or pain-related behavior during nursing home stay and at the end of life...
June 2016: CNS Drugs
https://www.readbyqxmd.com/read/27192949/hypnosis-for-pain-management-during-labour-and-childbirth
#4
REVIEW
Kelly Madden, Philippa Middleton, Allan M Cyna, Mandy Matthewson, Leanne Jones
BACKGROUND: This review is one in a series of Cochrane reviews investigating pain management for childbirth. These reviews all contribute to an overview of systematic reviews of pain management for women in labour, and share a generic protocol. This review updates an earlier version of the review of the same title. OBJECTIVES: To examine the effectiveness and safety of hypnosis for pain management during labour and childbirth. SEARCH METHODS: We searched the Cochrane Pregnancy and Childbirth Group's Trials Register (30 September 2015) and the reference lists of primary studies and review articles...
2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/27146570/two-pseudo-enantiomeric-forms-of-n-benzyl-4-hydroxy-1-methyl-2-2-dioxo-1h-2%C3%AE-6-1-benzothiazine-3-carboxamide-and-their-analgesic-properties
#5
Igor V Ukrainets, Svitlana V Shishkina, Vyacheslav N Baumer, Olga V Gorokhova, Lidiya A Petrushova, Galina Sim
The fact that molecular crystals exist as different polymorphic modifications and the identification of as many polymorphs as possible are important considerations for the pharmaceutic industry. The molecule of N-benzyl-4-hydroxy-1-methyl-2,2-dioxo-1H-2λ(6),1-benzothiazine-3-carboxamide, C17H16N2O4S, does not contain a stereogenic atom, but intramolecular hydrogen-bonding interactions engender enantiomeric chiral conformations as a labile racemic mixture. The title compound crystallized in a solvent-dependent single chiral conformation within one of two conformationally polymorphic P212121 orthorhombic chiral crystals (denoted forms A and B)...
May 1, 2016: Acta Crystallographica. Section C, Structural Chemistry
https://www.readbyqxmd.com/read/27125288/intrathecal-therapy-for-cancer-related-pain
#6
Brian M Bruel, Allen W Burton
OBJECTIVE: The increasing incidence of cancer survivorship has shifted treatment of cancer-related pain from short-term analgesia to long-term chronic pain management. As a result, alternatives to oral analgesics, such as intrathecal therapy, may be beneficial for patients with cancer-related pain. The authors review the use of intrathecal therapy in the management of cancer-related pain. METHODS: The Medline database was searched for English-language articles that included "ziconotide" or "morphine" AND ("cancer" OR "malignant") AND "intrathecal" in title or abstract...
April 28, 2016: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/26935254/neuropathic-low-back-pain-in-clinical-practice
#7
REVIEW
R Baron, A Binder, N Attal, R Casale, A H Dickenson, R-D Treede
BACKGROUND AND OBJECTIVE: Low back pain (LBP) is one of the most common chronic pain conditions. This paper reviews the available literature on the role of neuropathic mechanisms in chronic LBP and discusses implications for its clinical management, with a particular focus on pharmacological treatments. DATABASES AND DATA TREATMENT: Literature searches were performed in PubMed, key pain congresses and ProQuest Dialog to identify published evidence on neuropathic back pain and its management...
July 2016: European Journal of Pain: EJP
https://www.readbyqxmd.com/read/26889627/perioperative-dexmedetomidine-for-acute-pain-after-abdominal-surgery-in-adults
#8
REVIEW
Luise Jessen Lundorf, Helene Korvenius Nedergaard, Ann Merete Møller
BACKGROUND: Acute postoperative pain is still an issue in patients undergoing abdominal surgery. Postoperative pain and side effects of analgesic treatment, in particular those of opioids, need to be minimized. Opioid-sparing analgesics, possibly including dexmedetomidine, seem a promising avenue by which to improve postoperative outcomes. OBJECTIVES: Our primary aim was to determine the analgesic efficacy and opioid-sparing effect of perioperative dexmedetomidine for acute pain after abdominal surgery in adults...
February 18, 2016: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26859719/headache-chronic-tension-type
#9
Mona Ghadiri-Sani, Nicholas Silver
INTRODUCTION: Chronic tension-type headache (CTTH) is a disorder that evolves from episodic tension-type headache, with daily, or very frequent, episodes of headache lasting hours or they may be continuous. It affects up to 4% of the general population, and is more prevalent in women (up to 65% of cases). METHODS AND OUTCOMES: We conducted a systematic overview, aiming to answer the following clinical questions: What are the effects of drug treatments for CTTH? What are the effects of non-drug treatments for CTTH? We searched: Medline, Embase, The Cochrane Library, and other important databases up to December 2013 (Clinical Evidence overviews are updated periodically; please check our website for the most up-to-date version of this overview)...
2016: Clinical Evidence
https://www.readbyqxmd.com/read/26740206/synthesis-biological-evaluation-and-pharmacokinetic-studies-of-mefenamic-acid-n-hydroxymethylsuccinimide-ester-prodrug-as-safer-nsaid
#10
Asif Husain, Priyanka Ahuja, Aftab Ahmad, Shah A Khan
BACKGROUND: Non steroidal anti-inflammatory drugs are the most widely prescribed drugs to manage pain and inflammatory conditions, but their long term use is associated with gastrointestinal toxicity. OBJECTIVES: The study aimed to synthesize an ester-based prodrug of a non steroidal anti-inflammatory agent, mefenamic acid in order to improve the therapeutic index vis a vis to overcome the side effects such as gastrointestinal irritation and bleeding associated with the use of mefenamic acid...
2016: Medicinal Chemistry
https://www.readbyqxmd.com/read/26555612/leuckart-synthesis-and-pharmacological-assessment-of-novel-acetamide-derivatives
#11
Priyanka Rani, Dilipkumar Pal, Rahul Rama Hegde, Syed Riaz Hashim
A new concatenation of N-(1-(4-bromophenyl)ethyl)-2-phenoxyacetamide and N-(1-(4-methoxyphenyl) ethyl)-2-phenoxyacetamide derivatives having 2-phenoxy-N-(1-phenylethyl)acetamide nucleus as common in both the types was synthesized for the sake of achieve titled compounds as potential cytotoxic, anti-inflammatory, analgesic and antipyretic agents. All the novel derivatives have been synthesized through multi-step reaction sequence starting from Leuckart reaction. The structural assignments of the new compounds have been determined by virtue of their IR, 1H NMR, 13C NMR, elemental analysis and mass spectrum analysis...
2016: Anti-cancer Agents in Medicinal Chemistry
https://www.readbyqxmd.com/read/26544675/non-prescription-otc-oral-analgesics-for-acute-pain-an-overview-of-cochrane-reviews
#12
REVIEW
R Andrew Moore, Philip J Wiffen, Sheena Derry, Terry Maguire, Yvonne M Roy, Laila Tyrrell
BACKGROUND: Non-prescription (over-the-counter, or OTC) analgesics (painkillers) are used frequently. They are available in various brands, package sizes, formulations, and dose. They can be used for a range of different types of pain, but this overview reports on how well they work for acute pain (pain of short duration, usually with rapid onset). Thirty-nine Cochrane reviews of randomised trials have examined the analgesic efficacy of individual drug interventions in acute postoperative pain...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26121600/spinal-cord-stimulation-for-cancer-related-pain-in-adults
#13
REVIEW
Lihua Peng, Su Min, Zhou Zejun, Ke Wei, Michael I Bennett
BACKGROUND: This is an update of a review first published in The Cochrane Library in Issue 3, 2013. Cancer-related pain places a heavy burden on public health with related high expenditure. Severe pain is associated with a decreased quality of life in patients with cancer. A significant proportion of patients with cancer-related pain are under-treated. There is a need for more effective control of cancer-related pain. Spinal cord stimulation (SCS) may have a role in pain management. The effectiveness and safety of SCS for patients with cancer-related pain is currently unknown...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/26036692/the-role-of-physical-activity-and-psychological-coping-strategies-in-the-management-of-painful-diabetic-neuropathy-a-systematic-review-of-the-literature
#14
REVIEW
Ben Davies, Fiona Cramp, Jeremy Gauntlett-Gilbert, David Wynick, Candida S McCabe
BACKGROUND: Diabetes is rising in prevalence; painful diabetic neuropathy (PDN) is one complication of diabetes. PDN is primarily managed with medication but analgesic failure is common and people remain in pain and distress. It is unclear whether pain management strategies are appropriate for PDN. OBJECTIVES: To establish the effectiveness of physical activity and psychological coping strategies for PDN. DESIGN: Systematic literature review...
December 2015: Physiotherapy
https://www.readbyqxmd.com/read/25942496/sweet-tasting-solutions-for-reduction-of-needle-related-procedural-pain-in-children-aged-one-to-16-years
#15
REVIEW
Denise Harrison, Janet Yamada, Thomasin Adams-Webber, Arne Ohlsson, Joseph Beyene, Bonnie Stevens
BACKGROUND: Extensive evidence exists showing analgesic effects of sweet solutions for newborns and infants. It is less certain if the same analgesic effects exist for children one year to 16 years of age. This is an updated version of the original Cochrane review published in Issue 10, 2011 (Harrison 2011) titled Sweet tasting solutions for reduction of needle-related procedural pain in children aged one to 16 years. OBJECTIVES: To determine the efficacy of sweet tasting solutions or substances for reducing needle-related procedural pain in children beyond one year of age...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25921738/role-of-pituitary-adenylate-cyclase-activating-polypeptide-in-nociception-and-migraine
#16
REVIEW
Janos Tajti, Bernadett Tuka, Balint Botz, Zsuzsanna Helyes, Laszlo Vecsei
Pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors are widely distributed at different levels of the pain-processing pathway. Its action at the peripheral sensory nerve terminals has been found to be divergent; it can exert both pro- and anti-nociceptive effects, depending on the mode of administration (local or systemic) and the mechanism of the pain process (acute or chronic, inflammatory or neuropathic). In the central nervous system it exerts mainly neuronal excitation, leading to increased nociceptive signalling...
2015: CNS & Neurological Disorders Drug Targets
https://www.readbyqxmd.com/read/25744141/perineural-steroids-for-trauma-and-compression-related-peripheral-neuropathic-pain-a-systematic-review-and-meta-analysis
#17
REVIEW
Anuj Bhatia, David Flamer, Prakesh S Shah
PURPOSE: Perineural steroids are often used to treat chronic peripheral neuropathic pain (NP) secondary to trauma or compression. Nevertheless, when compared with local anesthetics (LA) or conventional medical management (CMM), their efficacy and safety in patients with trauma or compression-related neuropathic pain syndromes is unclear. The purpose of this systematic review and meta-analysis was to determine the efficacy and safety of perineural steroids in compression or trauma-related NP after one to three months of injection...
June 2015: Canadian Journal of Anaesthesia, Journal Canadien D'anesthésie
https://www.readbyqxmd.com/read/25661526/paediatric-nurses-postoperative-pain-management-practices-in-hospital-based-non-critical-care-settings-a-narrative-review
#18
REVIEW
Alison Twycross, Paula Forgeron, Anna Williams
OBJECTIVES: To investigate paediatric nurses' postoperative pain management practices with the aim of identifying the factors associated with undermanaged paediatric postoperative pain. DESIGN: Systematic search and review. DATA SOURCES: PsychInfo, CINAHL, PubMed, EMBASE and hand searching. REVIEW METHODS: English peer-reviewed quantitative, qualitative, or mixed methods research articles published between 1990 and 2012 exploring registered nurses' paediatric postoperative pain management practices were included...
April 2015: International Journal of Nursing Studies
https://www.readbyqxmd.com/read/25629804/chondroitin-for-osteoarthritis
#19
REVIEW
Jasvinder A Singh, Shahrzad Noorbaloochi, Roderick MacDonald, Lara J Maxwell
BACKGROUND: Osteoarthritis, a common joint disorder, is one of the leading causes of disability. Chondroitin has emerged as a new treatment. Previous meta-analyses have shown contradictory results on the efficacy of chondroitin. This, in addition to the publication of more trials, necessitates a systematic review. OBJECTIVES: To evaluate the benefit and harm of oral chondroitin for treating osteoarthritis compared with placebo or a comparator oral medication including, but not limited to, nonsteroidal anti-inflammatory drugs (NSAIDs), analgesics, opioids, and glucosamine or other "herbal" medications...
2015: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/25609995/pain-catastrophizing-as-a-risk-factor-for-chronic-pain-after-total-knee-arthroplasty-a-systematic-review
#20
REVIEW
Lindsay C Burns, Sarah E Ritvo, Meaghan K Ferguson, Hance Clarke, Ze'ev Seltzer, Joel Katz
BACKGROUND: Total knee arthroplasty (TKA) is a common and costly surgical procedure. Despite high success rates, many TKA patients develop chronic pain in the months and years following surgery, constituting a public health burden. Pain catastrophizing is a construct that reflects anxious preoccupation with pain, inability to inhibit pain-related fears, amplification of the significance of pain vis-à-vis health implications, and a sense of helplessness regarding pain. Recent research suggests that it may be an important risk factor for untoward TKA outcomes...
2015: Journal of Pain Research
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