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https://www.readbyqxmd.com/read/29054102/supporting-faculty-during-pedagogical-change-through-reflective-teaching-practice-an-innovative-approach
#1
Deborah K Armstrong, Marilyn E Asselin
Given the recent calls for transformation of nursing education, it is critical that faculty be reflective educators. Reflective teaching practice is a process of self-examination and self-evaluation to gain insight into teaching to improve the teaching-learning experience. Limited attention has been given to this notion in the nursing education literature. An innovative reflective teaching practice approach for nursing education is proposed, consisting of question cues, journaling, and a process of facilitated meetings...
November 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29054087/using-local-knowledge-and-sustainable-transport-to-promote-a-greener-city-the-case-of-bucharest-romania
#2
Mihai R Niță, Denisa L Badiu, Diana A Onose, Athanasios A Gavrilidis, Simona R Grădinaru, Irina I Năstase, Raffaele Lafortezza
Cities undergoing climate change and rapid urbanization are faced with significant transformational processes that affect the environment and society, challenging them to become more sustainable and resilient. The promotion of nature-based solutions represents an efficient approach to meet sustainability targets in cities and improve the quality of life of citizens. The association of large components of green infrastructure, such as urban parks, with physical activity can counteract the sedentary lifestyle endemic to cities and improve the overall health and well-being of individuals (Carrus et al...
October 17, 2017: Environmental Research
https://www.readbyqxmd.com/read/29054020/unraveling-the-mechanisms-behind-iron-overload-and-ineffective-hematopoiesis-in-myelodysplastic-syndromes
#3
REVIEW
Emanuele Angelucci, Paolo Cianciulli, Carlo Finelli, Cristina Mecucci, Maria Teresa Voso, Sante Tura
Myelodysplastic syndromes (MDS) are a group of clonally-acquired blood disorders characterized by ineffective hematopoiesis leading to cytopenias. Red blood cell transfusions are an important component of supportive care in patients with MDS. Prolonged exposure to transfusions can lead to iron overload, which results in iron-induced toxicity caused by the production of reactive oxygen species (ROS). ROS accumulation has detrimental effects also on hematopoietic stem cells and may contribute to MDS progression...
October 5, 2017: Leukemia Research
https://www.readbyqxmd.com/read/29054012/the-role-of-long-noncoding-rnas-in-cancer-the-dark-matter-matters
#4
REVIEW
Xiaowen Hu, Anil K Sood, Chi V Dang, Lin Zhang
Sequencing technology has facilitated a new era of cancer research, especially in cancer genomics. Using next-generation sequencing, thousands of long noncoding RNAs (lncRNAs) have been identified as abnormally altered in the cancer genome or differentially expressed in tumor tissues. These lncRNAs are associated with imbalanced gene regulation and aberrant biological processes that contribute to malignant transformation. The functions and therapeutic potential of cancer-related lncRNAs have attracted considerable interest in the past few years...
October 17, 2017: Current Opinion in Genetics & Development
https://www.readbyqxmd.com/read/29054005/adsorption-of-a-novel-reagent-scheme-on-scheelite-and-calcite-causing-an-effective-flotation-separation
#5
Yuesheng Gao, Zhiyong Gao, Wei Sun, Zhigang Yin, Jianjun Wang, Yuehua Hu
The efficient separation of scheelite from calcium-bearing minerals, especially calcite, remains a challenge in practice. In this work, a novel reagent scheme incorporating a depressant of sodium hexametaphosphate (SHMP) and a collector mixture of octyl hydroxamic acid (HXMA-8) and sodium oleate (NaOl) was employed in both single and mixed binary mineral flotation, and it proved to be highly effective for the separation. Furthermore, the role of the pH value in the separation was evaluated. Additionally, the mechanism of the selective separation was investigated systemically via zeta potential measurements, fourier transform infrared (FTIR) spectroscopy analysis, X-ray photoelectron (XPS) spectroscopy analysis and crystal chemistry calculations...
October 12, 2017: Journal of Colloid and Interface Science
https://www.readbyqxmd.com/read/29053991/molecular-mechanisms-of-development-of-the-human-fetal-female-reproductive-tract
#6
Gerald R Cunha, Takeshi Kurita, Mei Cao, Joel Shen, Stanley Robboy, Laurence Baskin
Human female reproductive tract development rests mostly upon hematoxilyn and eosin stained sections despite recent advances on molecular mechanisms in mouse studies. We report application of immunohistochemical methods to explore the ontogeny of epithelial and mesenchymal differentiation markers (keratins, homobox proteins, steroid receptors), transcription factors and signaling molecules (TP63 and RUNX1) during human female reproductive tract development. Keratins 6, 7, 8, 10, 14 and 19 (KRT6, KRT7, KRT8, KRT10, KRT14, KRT19) were expressed in a temporally and spatially dynamic fashion...
July 29, 2017: Differentiation; Research in Biological Diversity
https://www.readbyqxmd.com/read/29053988/intermedin-reduces-neointima-formation-by-regulating-vascular-smooth-muscle-cell-phenotype-via-camp-pka-pathway
#7
Qing Zhu, Xian-Qiang Ni, Wei-Wei Lu, Jin-Sheng Zhang, Jin-Ling Ren, Di Wu, Yao Chen, Lin-Shuang Zhang, Yan-Rong Yu, Chao-Shu Tang, Yong-Fen Qi
BACKGROUND AND AIMS: Vascular smooth muscle cell (VSMC) dedifferentiation contributes to neointima formation, which results in various vascular disorders. Intermedin (IMD), a cardiovascular paracrine/autocrine polypeptide, is involved in maintaining circulatory homeostasis. However, whether IMD protects against neointima formation remains largely unknown. The purpose of this study is to investigate the role of IMD in neointima formation and the possible mechanism. METHODS: IMD1-53 (100ng/kg/h) or saline water was used on rat carotid-artery balloon-injury model...
October 9, 2017: Atherosclerosis
https://www.readbyqxmd.com/read/29053966/transforming-lipoxygenases-pe-specific-enzymes-in-disguise
#8
Ling F Ye, Brent R Stockwell
In this issue of Cell, Wenzel et al. solve a long-standing mystery regarding how damage to cell membranes occurs during ferroptosis, an iron-dependent form of regulated cell death. They found that lipoxygenases are like Transformer toys, being converted from one enzyme type to another in the presence of the protein PEBP1.
October 19, 2017: Cell
https://www.readbyqxmd.com/read/29053919/tuning-the-two-dimensional-electron-liquid-at-oxide-interfaces-by-buffer-layer-engineered-redox-reactions
#9
Yunzhong Chen, Robert J Green, Ronny Sutarto, Feizhou He, Søren Linderoth, George Sawatzky, Nini Pryds
Polar discontinuities and redox reactions provide alternative paths to create two-dimensional electron liquids (2DELs) at oxide interfaces. Herein, we report high mobility 2DELs at interfaces involving SrTiO3 (STO) achieved using polar La7/8Sr1/8MnO3 (LSMO) buffer layers to manipulate both polarities and redox reactions from disordered overlayers grown at room temperature. Using resonant x-ray reflectometry experiments, we quantify redox reactions from oxide overlayers on STO as well as polarity induced electronic reconstruction at epitaxial LSMO/STO interfaces...
October 20, 2017: Nano Letters
https://www.readbyqxmd.com/read/29053848/is-virtual-reality-ready-for-prime-time-in-the-medical-space-a-randomized-control-trial-of-pediatric-virtual-reality-for-acute-procedural-pain-management
#10
Jeffrey I Gold, Nicole E Mahrer
Objective: To conduct a randomized control trial to evaluate the feasibility and efficacy of virtual reality (VR) compared with standard of care (SOC) for reducing pain, anxiety, and improving satisfaction associated with blood draw in children ages 10-21 years. Methods: In total, 143 triads (patients, their caregiver, and the phlebotomist) were recruited in outpatient phlebotomy at a pediatric hospital and randomized to receive either VR or SOC when undergoing routine blood draw...
October 19, 2017: Journal of Pediatric Psychology
https://www.readbyqxmd.com/read/29053806/independent-association-of-plasma-hydroxysphingomyelins-with-physical-function-in-the-atherosclerosis-risk-in-communities-aric-study
#11
Danni Li, Jeffrey R Misialek, Fangying Huang, B Gwen Windham, Fang Yu, Alvaro Alonso
Background: Plasma metabolites such as phosphatidylcholines (PCs) and sphingomyelins (SMs) are associated with in age-related cognitive decline. However, their relations to age-related physical function decline remain largely unknown. Methods: We examined the cross-sectional relations of 12 plasma metabolites (including 4 PCs and 4 SMs) with physical function in 383 older adults in the Atherosclerosis Risk in Communities study at the fifth exam (2011-13, mean age [standard deviation (SD)]: 78...
October 19, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/29053757/generation-of-composite-persea-americana-mill-avocado-plants-a-proof-of-concept-study
#12
S Ashok Prabhu, Buyani Ndlovu, Juanita Engelbrecht, Noëlani van den Berg
Avocado (Persea americana (Mill.)), an important commercial fruit, is severely affected by Phytophthora Root Rot in areas where the pathogen is prevalent. However, advances in molecular research are hindered by the lack of a high-throughput transient transformation system in this non-model plant. In this study, a proof-of-concept is demonstrated by the successful application of Agrobacterium rhizogenes-mediated plant transformation to produce composite avocado plants. Two ex vitro strategies were assessed on two avocado genotypes (Itzamna and A0...
2017: PloS One
https://www.readbyqxmd.com/read/29053627/silicon-nanocrystals-with-ph-sensitive-tunable-light-emission-from-violet-to-blue-green
#13
Jing Wang, Junhong Guo, Jing Chen
We fabricated a silicon nanocrystal (NC) suspension with visible, continuous, tunable light emission with pH sensitivity from violet to blue-green. Transmission electron microscopy (TEM) images and X-ray diffraction (XRD) pattern analysis exhibit the highly crystalline nanoparticles of silicon. Photoluminescence (PL) spectra and photoluminescence excitation (PLE) spectra at different pH values, such as 1, 3, 5, 7, 9, and 11, reveal the origins of light emission from the silicon NC suspension, which includes both the quantum confinement effect and surface bonding...
October 20, 2017: Sensors
https://www.readbyqxmd.com/read/29053573/preparation-and-characterization-of-ternary-antimicrobial-films-of-%C3%AE-cyclodextrin-allyl-isothiocyanate-polylactic-acid-for-the-enhancement-of-long-term-controlled-release
#14
Jinpeng Wang, Chao Qiu, Ganesan Narsimhan, Zhengyu Jin
Allyl isothiocyanate (AITC) are natural essential oil components that have outstanding antimicrobial activities. However, low water solubility, high volatility, and easy degradation by heat, restricting their application in food packing industry. Development of the inclusion complex of β-cyclodextrin/AITC (β-CD/AITC) is a promising solution. Furthermore, the incorporation of β-CD/AITC complex into polylactic acid (PLA) films would be an attractive method to develop food antimicrobial materials. The aim of this study was to evaluate the enhancement in physicochemical properties, antimicrobial activities, and controlled release of β-CD/AITC from such films...
October 20, 2017: Materials
https://www.readbyqxmd.com/read/29053535/histologic-status-of-squamous-cell-carcinoma-in-situ-after-diagnostic-biopsy-in-immunocompetent-and-immunosuppressed-patients
#15
Eduardo K Moioli, Clifford Hsieh, Angela Tisch, Diana Bolotin
BACKGROUND: The histologic status of squamous cell carcinoma in situ (SCC-IS) after diagnostic biopsy has not been well described or compared between immunocompetent and immunosuppressed patients. Expression of immunohistochemical (IHC) markers of aggressive SCC has not been compared between SCC-IS that clears or becomes invasive after biopsy. OBJECTIVE: To determine the histologic status of SCC-IS after diagnostic biopsy in these populations. METHODS: Retrospective analysis of 129 patients with SCC-IS treated with excision and 55 patients treated with Mohs surgery...
October 19, 2017: Dermatologic Surgery: Official Publication for American Society for Dermatologic Surgery [et Al.]
https://www.readbyqxmd.com/read/29053525/transforming-nursing-education-a-call-for-a-conceptual-approach
#16
Frederica Feller
In an effort to meet the changing landscape of the health care system and the explosion of nursing knowledge, the Institute of Medicine and the Robert Wood Johnston Foundation have summoned nursing academia to partner on curriculum development with an emphasis on the professional socialization of the new nurse. As health care continues to change, the education of nurses must also evolve to meet these changes. Curriculum transformation is needed at nearly every aspect of health care. This policy statement will explore these challenges and the transformation in nursing education required to meet them...
October 20, 2017: Nursing Education Perspectives
https://www.readbyqxmd.com/read/29053518/role-of-homeodomain-interacting-protein-kinase-2-in-the-pathogenesis-of-tissue-fibrosis-in-keloid-derived-keratinocytes
#17
Yi-Xuan Zhao, Guo-You Zhang, An-Yuan Wang, Ya-Hong Chen, Da-Mu Lin, Qing-Feng Li
Epithelial-mesenchymal transition (EMT) plays a critical role in fibrotic keloid formation, which is characterized by excessive collagen and extracellular matrix synthesis and deposition. Growing evidence suggests that the serine/threonine kinase homeodomain-interacting protein kinase 2 (HIPK2) acts upstream of several major fibrosis signaling pathways; however, the role of HIPK2 in the keloid fibrogenesis remains unknown. In the current study, we investigated the roles of HIPK2 in the pathogenesis of keloids...
October 19, 2017: Annals of Plastic Surgery
https://www.readbyqxmd.com/read/29053477/revisiting-local-structural-changes-in-geo2-glass-at-high-pressure
#18
Juncai Dong, Hurong Yao, Zhiying Guo, Quanjie Jia, Yan Wang, Pengfei An, Yu Gong, Yaxiang Liang, Dongliang Chen
Despite the great importance in fundamental and industrial fields, understanding structural changes for pressure-induced polyamorphism in network-forming glasses remains a formidable challenge. Here, we revisited the local structural transformations in GeO2 glass up to 54 GPa using x-ray absorption fine structure (XAFS) spectroscopy via a combination diamond anvil cell and polycapillary half-lens. Three polyamorphic transitions can be clearly identified by XAFS structure refinement. First, a progressive increase of the nearest Ge-O distance and bond disorder to a maximum at ~5-16 GPa, in the same pressure region of previously observed tetrahedral-octahedral transformation...
October 20, 2017: Journal of Physics. Condensed Matter: An Institute of Physics Journal
https://www.readbyqxmd.com/read/29053447/multimodal-mr-synthesis-via-modality-invariant-latent-representation
#19
Agisilaos Chartsias, Thomas Joyce, Mario Valerio Giuffrida, Sotirios A Tsaftaris
We propose a multi-input multi-output fully convolutional neural network model for MRI synthesis. The model is robust to missing data, as it benefits from, but does not require, additional input modalities. The model is trained end-to-end, and learns to embed all input modalities into a shared modalityinvariant latent space. These latent representations are then combined into a single fused representation, which is transformed into the target output modality with a learnt decoder. We avoid the need for curriculum learning by exploiting the fact that the various input modalities are highly correlated...
October 17, 2017: IEEE Transactions on Medical Imaging
https://www.readbyqxmd.com/read/29053442/posterior-parietal-cortex-estimates-the-relationship-between-object-and-body-location-during-locomotion
#20
Daniel S Marigold, Trevor Drew
We test the hypothesis that the posterior parietal cortex (PPC) contributes to the control of visually guided locomotor gait modifications by constructing an estimation of object location relative to body state, and in particular the changing gap between them. To test this hypothesis, we recorded neuronal activity from areas 5b and 7 of the PPC of cats walking on a treadmill and stepping over a moving obstacle whose speed of advance was varied (slowed or accelerated with respect to the speed of the cat). We found distinct populations of neurons in the PPC, primarily in area 5b, that signaled distance- or time-to-contact with the obstacle, regardless of which limb was the first to step over the obstacle...
October 20, 2017: ELife
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