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https://www.readbyqxmd.com/read/28553748/mini-review-toxic-tendinopathy
#1
Brad Bolon
Toxic tendinopathy is a rare but reproducible complication in humans, given agents of four drug classes: aromatase inhibitors, fluoroquinolone antibiotics, glucocorticoids (long-term regimens), and statins. Toxic tendinopathy in humans has been linked less consistently to treatment with anabolic steroids, antiretroviral agents (mainly protease inhibitors), metalloproteinase inhibitors (MMPI), and isotretinoin. Classic drug-induced tendinopathies appear as "tendinosis" (i.e., progressive tendon degeneration without inflammation), although cases associated with aromatase inhibitors exhibit mainly tenosynovitis...
January 1, 2017: Toxicologic Pathology
https://www.readbyqxmd.com/read/28498222/ultrasonic-percutaneous-tenotomy-for-recalcitrant-calcific-triceps-tendinosis-in-a-competitive-strongman-a-case-report
#2
Mederic M Hall, Lisa Woodroffe
No abstract text is available yet for this article.
May 2017: Current Sports Medicine Reports
https://www.readbyqxmd.com/read/28495412/radiofrequency-microdebridement-versus-surgical-decompression-for-achilles-tendinosis-a-randomized-controlled-trial
#3
Rory J M Morrison, Timothy M Brock, Mike R Reed, Scott D Muller
Achilles tendinosis is primarily managed nonoperatively with activity modification and physiotherapy, although surgery can be required. This has classically involved surgical decompression of the Achilles tendon, although the use of radiofrequency microdebridement has been suggested as a novel minimally invasive alternative. We present a randomized controlled trial comparing radiofrequency microdebridement using the Topaz(®) microdebrider wand and traditional surgical decompression. All patients with Achilles tendinosis referred to a single surgeon and meeting the inclusion criteria were invited to participate in our single-blinded, randomized controlled study...
July 2017: Journal of Foot and Ankle Surgery: Official Publication of the American College of Foot and Ankle Surgeons
https://www.readbyqxmd.com/read/28483683/the-use-of-dehydrated-human-amnion-chorion-membrane-allograft-injection-for-the-treatment-of-tendinopathy-or-arthritis-a-case-series-involving-40-patients
#4
Alfred C Gellhorn, Alex Han
BACKGROUND: Degenerative joint and tendon injuries remain difficult to treat, with few effective conservative treatment options available. Regenerative approaches aim to promote the inherent healing capacity of injured tissues. Micronized dehydrated human amnion/chorion membrane (dHACM) injection is an emerging regenerative option with promising preclinical results. OBJECTIVE: To test the clinical effectiveness of dHACM injection in patients with chronic tendinopathy and arthropathy...
May 6, 2017: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/28411875/association-between-lateral-patellar-osteoarthrosis-and-knee-morphology-and-alignment-in-young-adults
#5
R Sebro, S Weintraub
AIM: To assess whether patellar and trochlea morphology and patellar alignment are associated with lateral patellar osteoarthrosis/chondrosis (OAC) in young adults. MATERIALS AND METHODS: Magnetic resonance imaging (MRI) images of 183 subjects (81 cases, 102 controls) aged 21-35 years of age were evaluated. Quantitative measurements of patella and trochlea morphology and patellar alignment were obtained. Axial and sagittal MRI images were reviewed to grade the severity of focal cartilage defects along the lateral facet of the patella...
April 12, 2017: Clinical Radiology
https://www.readbyqxmd.com/read/28399642/acute-tears-of-the-tibialis-posterior-tendon-following-ankle-sprain
#6
Lyle T Jackson, Linda J Dunaway, Gregory A Lundeen
BACKGROUND: Traumatic tears of the tibialis posterior (TP) tendon following an ankle sprain are rare. The purpose of this study was to report our case series of TP tendon tears following an ankle sprain. METHODS: Patients with persistent TP tendon pain after an ankle sprain were retrospectively identified over a 4-year period and reviewed. A comparison of magnetic resonance imaging (MRI) interpretations by a radiologist and surgeon was made. Patients failing conservative management underwent operative repair of the TP tendon tear and concomitant pathology...
April 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28394713/elbow-mri-findings-do-not-correlate-with-future-placement-on-the-disabled-list-in-asymptomatic-professional-baseball-pitchers
#7
Nicholas M Gutierrez, Christopher Granville, Lee Kaplan, Michael Baraga, Jean Jose
BACKGROUND: Injury rates among professional baseball players may reach as high as 5.8 per 1000 encounters, with pitchers being most vulnerable on account of the excessive biomechanical load on the upper extremity during the throwing motion. Anatomically, the shoulder is the most common site of pitching-related injury, accounting for 30.7% of injuries, closely followed by the elbow at 26.3%. Characteristic valgus loading imparts a predictable constellation of stresses on the joint, including medial tension, lateral compression, and posterior medial shearing...
May 2017: Sports Health
https://www.readbyqxmd.com/read/28382186/sonographic-evaluation-of-structural-changes-in-post-stroke-hemiplegic-shoulders
#8
Bukunmi Michael Idowu, Oluwagbemiga Oluwole Ayoola, Victor Adebayo Adetiloye, Morenikeji Adeyoyin Komolafe
BACKGROUND: Stroke and hemiplegia are frequent complications of stroke. This study was performed to sonographically evaluate post-stroke hemiplegic shoulders and explore possible relationship(s) between the sonographic findings and clinical indices. MATERIAL/METHODS: Forty-five stroke patients and 45 age- and sex-matched controls were recruited. Standard sonographic examination of both shoulders was performed to assess for joint subluxation, rotator cuff tears, tendinosis, subacromial-subdeltoid bursitis or effusion and adhesive capsulitis...
2017: Polish Journal of Radiology
https://www.readbyqxmd.com/read/28355673/the-extensor-mechanism-imaging-and-intervention
#9
Colm J McMahon, Arun Ramappa, Kenneth Lee
We present an overview of imaging and intervention of the extensor mechanism of the knee. Particular focus is placed on the evaluation of patellofemoral tracking disorders, patellar and quadriceps tendinosis and tears, patellar fracture, lateral patellar condyle patellar friction syndrome, and prepatellar bursitis. Anatomical and biomechanical factors contributing to these disorders are considered. Imaging evaluation is presented in a clinical context, and therapeutic options for these disorders are discussed...
April 2017: Seminars in Musculoskeletal Radiology
https://www.readbyqxmd.com/read/28301610/the-effects-of-substance-p-and-acetylcholine-on-human-tenocyte-proliferation-converge-mechanistically-via-tgf-%C3%AE-1
#10
Gloria Fong, Ludvig J Backman, Håkan Alfredson, Alex Scott, Patrik Danielson
Previous in vitro studies on human tendon cells (tenocytes) have demonstrated that the exogenous administration of substance P (SP) and acetylcholine (ACh) independently result in tenocyte proliferation, which is a prominent feature of tendinosis. Interestingly, the possible link between SP and ACh has not yet been explored in human tenocytes. Recent studies in other cell types demonstrate that both SP and ACh independently upregulate TGF-β1 expression via their respective receptors, the neurokinin 1 receptor (NK-1R) and muscarinic ACh receptors (mAChRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28264197/simvastatin-and-atorvastatin-reduce-the-mechanical-properties-of-tendon-constructs-in-vitro-and-introduce-catabolic-changes-in-the-gene-expression-pattern
#11
Pernilla Eliasson, Rene B Svensson, Antonis Giannopoulos, Christian Eismark, Michael Kjær, Peter Schjerling, Katja M Heinemeier
Treatment with lipid-lowering drugs, statins, is common all over the world. Lately, the occurrence of spontaneous tendon ruptures or tendinosis have suggested a negative influence of statins upon tendon tissue. But how statins might influence tendons is not clear. In the present study, we investigated the effect of statin treatment on mechanical strength, cell proliferation, collagen content and gene expression pattern in a tendon-like tissue made from human tenocytes in vitro. Human tendon fibroblasts were grown in a 3D tissue culture model (tendon constructs), and treated with either simvastatin or atorvastatin, low or high dose, respectively, for up to seven days...
2017: PloS One
https://www.readbyqxmd.com/read/28263673/demystifying-the-clinical-diagnosis-of-greater-trochanteric-pain-syndrome-in-women
#12
Charlotte Ganderton, Adam Semciw, Jill Cook, Tania Pizzari
OBJECTIVE: To evaluate the diagnostic accuracy of 10 clinical tests that can be used in the diagnosis of greater trochanteric pain syndrome (GTPS) in women, and to compare these clinical tests to magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS: Twenty-eight participants with GTPS (49.5 ± 22.0 years) and 18 asymptomatic participants (mean age ± standard deviation [SD], 52.5 ± 22.8 years) were included. A blinded physiotherapist performed 10 pain provocation tests potentially diagnostic for GTPS-palpation of the greater trochanter, resisted external derotation test, modified resisted external derotation test, standard and modified Ober's tests, Patrick's or FABER test, resisted hip abduction, single-leg stance test, and the resisted hip internal rotation test...
June 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28257670/noninsertional-achilles-tendinopathy-pathologic-background-and-clinical-examination
#13
REVIEW
Mindi Feilmeier
The term tendinopathy includes a series of pathologies, all of which have a combination of pain, swelling, and impaired performance. The terms tendinosis, tendinitis and peritendinitis are all within the main heading of tendinopathy; this terminology provides a more accurate understanding of the condition and highlights the uniformity of clinical findings while distinguishing the individual histopathological findings of each condition. Understanding the clinical features and the underlying histopathology leads to a more accurate clinical diagnosis and subsequent treatment selection...
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28238018/the-iliotibial-tract-imaging-anatomy-injuries-and-other-pathology
#14
REVIEW
Russell Flato, Giovanni J Passanante, Matthew R Skalski, Dakshesh B Patel, Eric A White, George R Matcuk
The iliotibial tract, also known as Maissiat's band or the iliotibial band, and its associated muscles function to extend, abduct, and laterally rotate the hip, as well as aid in the stabilization of the knee. A select group of associated injuries and pathologies of the iliotibial tract are seen as sequela of repetitive stress and direct trauma. This article intends to educate the radiologist, orthopedist, and other clinicians about iliotibial tract anatomy and function and the clinical presentation, pathophysiology, and imaging findings of associated pathologies...
May 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28233017/-tendinopathies-of-the-shoulder-and-elbow
#15
Nael Hawi, Emmanouil Liodakis, Maximilian Petri, Christian Krettek, Rupert Meller
BACKGROUND: Tendinopathies of the shoulder and elbow joint are a common problem. According to the current state of knowledge tendinopathies can be separated into acute and chronic tendinitis as well as degenerative tendinosis. ORIGIN: The causes of tendinopathy can be intrinsic, extrinsic or a combination of both. A false straining or overuse with repetitive microtrauma is often the cause. Particularly affected are tendons of the rotator cuff, the long biceps tendons and lower arm extensors...
March 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28232805/physiological-mechanisms-of-eccentric-contraction-and-its-applications-a-role-for-the-giant-titin-protein
#16
REVIEW
Anthony L Hessel, Stan L Lindstedt, Kiisa C Nishikawa
When active muscles are stretched, our understanding of muscle function is stretched as well. Our understanding of the molecular mechanisms of concentric contraction has advanced considerably since the advent of the sliding filament theory, whereas mechanisms for increased force production during eccentric contraction are only now becoming clearer. Eccentric contractions play an important role in everyday human movements, including mobility, stability, and muscle strength. Shortly after the sliding filament theory of muscle contraction was introduced, there was a reluctant recognition that muscle behaved as if it contained an "elastic" filament...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28203592/suture-only-repair-versus-suture-anchor-augmented-repair-for-achilles-tendon-ruptures-with-a-short-distal-stump-a-biomechanical-comparison
#17
Michael A Boin, Matthew A Dorweiler, Christopher J McMellen, Gregory C Gould, Richard T Laughlin
BACKGROUND: Chronic noninsertional Achilles tendinosis can result in an acute Achilles tendon rupture with a short distal stump. In such tendon ruptures, there is a limited amount of adequate tissue that can hold suture, thus presenting a challenge for surgeons who elect to treat the rupture operatively. HYPOTHESIS: Adding suture anchors to the repair construct may result in biomechanically stronger repairs compared with a suture-only technique. STUDY DESIGN: Controlled laboratory study...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203584/plantaris-excision-reduces-pain-in-midportion-achilles-tendinopathy-even-in-the-absence-of-plantaris-tendinosis
#18
James D F Calder, Joanna M Stephen, C Niek van Dijk
BACKGROUND: It is becoming increasingly apparent that the plantaris can contribute to symptoms in at least a subset of patients with midportion Achilles tendinopathy. However, the nature of its involvement remains unclear. PURPOSE: To determine whether excised plantaris tendons from patients with midportion Achilles tendinopathy display tendinopathic changes and whether the presence of such changes affect clinical outcomes. STUDY DESIGN: Case series; Level of evidence, 4...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28195608/proximal-hamstring-tendinosis-and-partial-ruptures
#19
Ashley N Startzman, Oliver Fowler, Dominic Carreira
Proximal hamstring tendinosis and partial hamstring origin ruptures are painful conditions of the proximal thigh and hip that may occur in the acute, chronic, or acute on chronic setting. Few publications exist related to their diagnosis and management. This systematic review discusses the incidence, treatment, and prognosis of proximal hamstring tendinosis and partial hamstring ruptures. Conservative treatment measures include nonsteroidal anti-inflammatory drugs, physical therapy, rest, and ice. If these measures fail, platelet-rich plasma or shockwave therapy may be considered...
February 13, 2017: Orthopedics
https://www.readbyqxmd.com/read/28149740/surgical-technique-jumper-s-knee-arthroscopic-treatment-of-chronic-tendinosis-of-the-patellar-tendon
#20
Matthias Brockmeyer, Alexander Haupert, Dieter Kohn, Olaf Lorbach
Chronic patellar tendinosis (jumper's knee) is a common problem among athletes. Conservative treatment is successful in most of the cases including, among others, the use of nonsteroidal anti-inflammatory drugs, local cryotherapy, eccentric muscle training, limitation of sports activity, and local infiltration. In approximately 10% of conservatively treated patients, conservative treatment fails and surgery is required. Different open and arthroscopic surgical techniques have been described in the literature...
December 2016: Arthroscopy Techniques
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