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https://www.readbyqxmd.com/read/28301610/the-effects-of-substance-p-and-acetylcholine-on-human-tenocyte-proliferation-converge-mechanistically-via-tgf-%C3%AE-1
#1
Gloria Fong, Ludvig J Backman, Håkan Alfredson, Alex Scott, Patrik Danielson
Previous in vitro studies on human tendon cells (tenocytes) have demonstrated that the exogenous administration of substance P (SP) and acetylcholine (ACh) independently result in tenocyte proliferation, which is a prominent feature of tendinosis. Interestingly, the possible link between SP and ACh has not yet been explored in human tenocytes. Recent studies in other cell types demonstrate that both SP and ACh independently upregulate TGF-β1 expression via their respective receptors, the neurokinin 1 receptor (NK-1R) and muscarinic ACh receptors (mAChRs)...
2017: PloS One
https://www.readbyqxmd.com/read/28264197/simvastatin-and-atorvastatin-reduce-the-mechanical-properties-of-tendon-constructs-in-vitro-and-introduce-catabolic-changes-in-the-gene-expression-pattern
#2
Pernilla Eliasson, Rene B Svensson, Antonis Giannopoulos, Christian Eismark, Michael Kjær, Peter Schjerling, Katja M Heinemeier
Treatment with lipid-lowering drugs, statins, is common all over the world. Lately, the occurrence of spontaneous tendon ruptures or tendinosis have suggested a negative influence of statins upon tendon tissue. But how statins might influence tendons is not clear. In the present study, we investigated the effect of statin treatment on mechanical strength, cell proliferation, collagen content and gene expression pattern in a tendon-like tissue made from human tenocytes in vitro. Human tendon fibroblasts were grown in a 3D tissue culture model (tendon constructs), and treated with either simvastatin or atorvastatin, low or high dose, respectively, for up to seven days...
2017: PloS One
https://www.readbyqxmd.com/read/28263673/demystifying-the-clinical-diagnosis-of-greater-trochanteric-pain-syndrome-in-women
#3
Charlotte Ganderton, Adam Semciw, Jill Cook, Tania Pizzari
OBJECTIVE: To evaluate the diagnostic accuracy of 10 clinical tests that can be used in the diagnosis of greater trochanteric pain syndrome (GTPS) in women, and to compare these clinical tests to magnetic resonance imaging (MRI) findings. MATERIALS AND METHODS: Twenty-eight participants with GTPS (49.5 ± 22.0 years) and 18 asymptomatic participants (mean age ± standard deviation [SD], 52.5 ± 22.8 years) were included. A blinded physiotherapist performed 10 pain provocation tests potentially diagnostic for GTPS-palpation of the greater trochanter, resisted external derotation test, modified resisted external derotation test, standard and modified Ober's tests, Patrick's or FABER test, resisted hip abduction, single-leg stance test, and the resisted hip internal rotation test...
March 6, 2017: Journal of Women's Health
https://www.readbyqxmd.com/read/28257670/noninsertional-achilles-tendinopathy-pathologic-background-and-clinical-examination
#4
REVIEW
Mindi Feilmeier
The term tendinopathy includes a series of pathologies, all of which have a combination of pain, swelling, and impaired performance. The terms tendinosis, tendinitis and peritendinitis are all within the main heading of tendinopathy; this terminology provides a more accurate understanding of the condition and highlights the uniformity of clinical findings while distinguishing the individual histopathological findings of each condition. Understanding the clinical features and the underlying histopathology leads to a more accurate clinical diagnosis and subsequent treatment selection...
April 2017: Clinics in Podiatric Medicine and Surgery
https://www.readbyqxmd.com/read/28238018/the-iliotibial-tract-imaging-anatomy-injuries-and-other-pathology
#5
REVIEW
Russell Flato, Giovanni J Passanante, Matthew R Skalski, Dakshesh B Patel, Eric A White, George R Matcuk
The iliotibial tract, also known as Maissiat's band or the iliotibial band, and its associated muscles function to extend, abduct, and laterally rotate the hip, as well as aid in the stabilization of the knee. A select group of associated injuries and pathologies of the iliotibial tract are seen as sequela of repetitive stress and direct trauma. This article intends to educate the radiologist, orthopedist, and other clinicians about iliotibial tract anatomy and function and the clinical presentation, pathophysiology, and imaging findings of associated pathologies...
May 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28233017/-tendinopathies-of-the-shoulder-and-elbow
#6
Nael Hawi, Emmanouil Liodakis, Maximilian Petri, Christian Krettek, Rupert Meller
BACKGROUND: Tendinopathies of the shoulder and elbow joint are a common problem. According to the current state of knowledge tendinopathies can be separated into acute and chronic tendinitis as well as degenerative tendinosis. ORIGIN: The causes of tendinopathy can be intrinsic, extrinsic or a combination of both. A false straining or overuse with repetitive microtrauma is often the cause. Particularly affected are tendons of the rotator cuff, the long biceps tendons and lower arm extensors...
March 2017: Der Unfallchirurg
https://www.readbyqxmd.com/read/28232805/physiological-mechanisms-of-eccentric-contraction-and-its-applications-a-role-for-the-giant-titin-protein
#7
REVIEW
Anthony L Hessel, Stan L Lindstedt, Kiisa C Nishikawa
When active muscles are stretched, our understanding of muscle function is stretched as well. Our understanding of the molecular mechanisms of concentric contraction has advanced considerably since the advent of the sliding filament theory, whereas mechanisms for increased force production during eccentric contraction are only now becoming clearer. Eccentric contractions play an important role in everyday human movements, including mobility, stability, and muscle strength. Shortly after the sliding filament theory of muscle contraction was introduced, there was a reluctant recognition that muscle behaved as if it contained an "elastic" filament...
2017: Frontiers in Physiology
https://www.readbyqxmd.com/read/28203592/suture-only-repair-versus-suture-anchor-augmented-repair-for-achilles-tendon-ruptures-with-a-short-distal-stump-a-biomechanical-comparison
#8
Michael A Boin, Matthew A Dorweiler, Christopher J McMellen, Gregory C Gould, Richard T Laughlin
BACKGROUND: Chronic noninsertional Achilles tendinosis can result in an acute Achilles tendon rupture with a short distal stump. In such tendon ruptures, there is a limited amount of adequate tissue that can hold suture, thus presenting a challenge for surgeons who elect to treat the rupture operatively. HYPOTHESIS: Adding suture anchors to the repair construct may result in biomechanically stronger repairs compared with a suture-only technique. STUDY DESIGN: Controlled laboratory study...
January 2017: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28203584/plantaris-excision-reduces-pain-in-midportion-achilles-tendinopathy-even-in-the-absence-of-plantaris-tendinosis
#9
James D F Calder, Joanna M Stephen, C Niek van Dijk
BACKGROUND: It is becoming increasingly apparent that the plantaris can contribute to symptoms in at least a subset of patients with midportion Achilles tendinopathy. However, the nature of its involvement remains unclear. PURPOSE: To determine whether excised plantaris tendons from patients with midportion Achilles tendinopathy display tendinopathic changes and whether the presence of such changes affect clinical outcomes. STUDY DESIGN: Case series; Level of evidence, 4...
December 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/28195608/proximal-hamstring-tendinosis-and-partial-ruptures
#10
Ashley N Startzman, Oliver Fowler, Dominic Carreira
Proximal hamstring tendinosis and partial hamstring origin ruptures are painful conditions of the proximal thigh and hip that may occur in the acute, chronic, or acute on chronic setting. Few publications exist related to their diagnosis and management. This systematic review discusses the incidence, treatment, and prognosis of proximal hamstring tendinosis and partial hamstring ruptures. Conservative treatment measures include nonsteroidal anti-inflammatory drugs, physical therapy, rest, and ice. If these measures fail, platelet-rich plasma or shockwave therapy may be considered...
February 13, 2017: Orthopedics
https://www.readbyqxmd.com/read/28149740/surgical-technique-jumper-s-knee-arthroscopic-treatment-of-chronic-tendinosis-of-the-patellar-tendon
#11
Matthias Brockmeyer, Alexander Haupert, Dieter Kohn, Olaf Lorbach
Chronic patellar tendinosis (jumper's knee) is a common problem among athletes. Conservative treatment is successful in most of the cases including, among others, the use of nonsteroidal anti-inflammatory drugs, local cryotherapy, eccentric muscle training, limitation of sports activity, and local infiltration. In approximately 10% of conservatively treated patients, conservative treatment fails and surgery is required. Different open and arthroscopic surgical techniques have been described in the literature...
December 2016: Arthroscopy Techniques
https://www.readbyqxmd.com/read/28118806/refractory-patella-tendinopathy-with-failed-conservative-treatment-shock-wave-or-arthroscopy
#12
Hlm Williams, S A Jones, C Lyons, C Wilson, A Ghandour
AIM: To identify whether the location of refractory patella tendinopathy (PT) has an effect on treatment modality (radial extracorporeal shock wave therapy (rESWT) or arthroscopic debridement). METHODS: Between 2012 and 2014, 40 patients with PT underwent a magnetic resonance imaging (MRI) scan. This confirmed the diagnosis as either involving the tendon itself (group A, 20) or with retropatella fat pad extension (group B, 20). All patients underwent rESWT. If there was no improvement patients proceeded with surgery in the form of arthroscopic debridement (by senior authors CW and AG)...
January 2017: Journal of Orthopaedic Surgery
https://www.readbyqxmd.com/read/27974984/technical-innovation-case-report-ultrasound-guided-prolotherapy-injection-for-insertional-achilles-calcific-tendinosis
#13
Benjamin K Buchanan, Jesse P DeLuca, Kyle P Lammlein
We describe the use of ultrasound guidance for hyperosmolar dextrose (prolotherapy) injection of the distal calcaneal tendon specifically just anterior to identified enthesophytes in patients with insertional Achilles calcific tendinosis refractory to conservative treatment. This specific technique has not to our knowledge been described or used in literature previously.
2016: Case Reports in Orthopedics
https://www.readbyqxmd.com/read/27868077/platelet-rich-plasma-injections-with-needle-tenotomy-for-gluteus-medius-tendinopathy-a-registry-study-with-prospective-follow-up
#14
James J Lee, Julian R Harrison, Kwadwo Boachie-Adjei, Elizabeth Vargas, Peter J Moley
BACKGROUND: Gluteal tendinopathy is a prevalent condition that can be associated with significant pain and disability. To date, no studies have prospectively assessed the efficacy of intratendinous platelet-rich plasma (PRP) injections as a minimally invasive treatment for gluteus medius tendinopathy. PURPOSE: To prospectively assess the efficacy of intratendinous PRP injections as treatment for chronic recalcitrant gluteus medius tendinopathy. STUDY DESIGN: Case series; Level of evidence, 4...
November 2016: Orthopaedic Journal of Sports Medicine
https://www.readbyqxmd.com/read/27855131/patellar-tendinopathy-diagnosis-and-treatment
#15
David Figueroa, Francisco Figueroa, Rafael Calvo
Patellar tendinopathy is a common cause of pain in athletes' knees. Historically, it has been related to jumping sports, such as volleyball and basketball. Repetitive jumping generates a considerable load of energy in the extensor mechanism, leading to symptoms. The main pathophysiologic phenomenon in patellar tendinopathy is tendinosis, which is a degenerative disorder rather than an inflammatory disorder; therefore, the other popular term for this disease, tendinitis, is not appropriate. The nonsurgical treatment of patellar tendinopathy is focused on eccentric exercises and often has good results...
December 2016: Journal of the American Academy of Orthopaedic Surgeons
https://www.readbyqxmd.com/read/27780771/percutaneous-needle-tenotomy-for-the-treatment-of-lateral-epicondylitis-a-systematic-review-of-the-literature
#16
REVIEW
Ryan Mattie, Joseph Wong, Zachary McCormick, Sloane Yu, Mikhail Saltychev, Katri Laimi
OBJECTIVE: To analyze the literature to determine whether controlled studies on percutaneous tenotomy have been published, and if so, to systematically assess the efficacy of percutaneous tenotomy for the treatment of tendinosis at the lateral epicondyle of the elbow. DESIGN: Systematic review of the available literature. METHODS: Cochrane Controlled Trials Register (CENTRAL), MEDLINE, EMBASE, CINAHL, and Web of Science databases were searched in November 2015, unrestricted by date...
October 22, 2016: PM & R: the Journal of Injury, Function, and Rehabilitation
https://www.readbyqxmd.com/read/27726748/ct-and-mr-imaging-of-the-postoperative-ankle-and-foot
#17
Gary M LiMarzi, Kurt F Scherer, Michael L Richardson, David R Warden, Christopher W Wasyliw, Jack A Porrino, Christopher R Pettis, Gideon Lewis, Christopher C Mason, Laura W Bancroft
A variety of surgical procedures exist for repair of both traumatic and degenerative osseous and soft-tissue pathologic conditions involving the foot and ankle. It is necessary for the radiologist to be familiar with these surgical procedures, so as to assess structural integrity, evaluate for complicating features, and avoid diagnostic pitfalls. Adequate interpretation of postoperative changes often requires access to surgical documentation to evaluate not only the surgery itself but the expected timeline for resolution of normal postoperative changes versus progressive disease...
October 2016: Radiographics: a Review Publication of the Radiological Society of North America, Inc
https://www.readbyqxmd.com/read/27723374/comparison-of-clinical-efficacy-among-endoscopy-assisted-radio-frequency-ablation-extracorporeal-shockwaves-and-eccentric-exercises-in-treatment-of-insertional-achilles-tendinosis
#18
Min Wei, Yujie Liu, Zhongli Li, Zhigang Wang
BACKGROUND: We sought to compare clinical efficacy among endoscopy-assisted radio-frequency ablation under local anesthesia, extracorporeal shockwaves (ESWs), and eccentric exercises in treating insertional Achilles tendinosis. METHODS: In this retrospective study, 78 patients diagnosed as having unilateral insertional Achilles tendinosis were enrolled. These participants underwent endoscopy-assisted radio-frequency ablation, ESWs, and eccentric calf muscle exercises between March 1, 2006, and February 28, 2011...
October 10, 2016: Journal of the American Podiatric Medical Association
https://www.readbyqxmd.com/read/27663654/greater-trochanteric-pain-syndrome-percutaneous-tendon-fenestration-versus-platelet-rich-plasma-injection-for-treatment-of-gluteal-tendinosis
#19
Jon A Jacobson, Corrie M Yablon, P Troy Henning, Irene S Kazmers, Andrew Urquhart, Brian Hallstrom, Asheesh Bedi, Aishwarya Parameswaran
OBJECTIVES: The purpose of this study was to compare ultrasound-guided percutaneous tendon fenestration to platelet-rich plasma (PRP) injection for treatment of greater trochanteric pain syndrome. METHODS: After Institutional Review Board approval was obtained, patients with symptoms of greater trochanteric pain syndrome and ultrasound findings of gluteal tendinosis or a partial tear (<50% depth) were blinded and treated with ultrasound-guided fenestration or autologous PRP injection of the abnormal tendon...
November 2016: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
https://www.readbyqxmd.com/read/27644578/efficacy-of-achilles-suture-bridge-technique-for-insertional-achilles-tendinosis-in-an-obese-and-athletic-patient
#20
Kazuaki Mineta, Naoto Suzue, Tetsuya Matsuura, Koichi Sairyo
Here, we report the efficacy of the suture bridge technique for treating insertional Achilles tendinosis in an obese and athletic patient. A 48-year-old man presented to our department with a 6-month history of left posterior heel pain. The patient was an athlete (triathlon) and appeared obese (height: 197 cm, body weight: 120 kg, body mass index: 30.9). A diagnosis of insertional Achilles tendinosis was made. Because 6 months of conservative treatments had failed, we performed open resection of the calcaneal exostosis and Haglund's deformity along with debridement of the degenerative tissue of the tendon...
2016: Journal of Medical Investigation: JMI
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