keyword
https://read.qxmd.com/read/38222722/hypoxic-ischaemic-encephalopathy-based-on-clinical-signs-and-symptoms-and-associated-factors-among-neonates-southern-ethiopian-public-hospitals-a-case-control-study
#21
JOURNAL ARTICLE
Getnet Melaku, Getachew Mergia, Senait Belay Getahun, Selamawit Semagn, Zemedu Awoke, Robel Hussien Kabthymer, Mesfin Abebe
BACKGROUND: Hypoxic-ischaemic encephalopathy (HIE) is a severe condition that results from reduced oxygen supply and blood flow to the brain, leading to brain injury and potential long-term neurodevelopmental impairments. This study aimed to identify the maternal and neonatal factors associated with hypoxic-ischaemic encephalopathy among Neonates. METHODS: The authors conducted a case-control study in 15 public hospitals with 515 neonates and mothers (175 cases and 340 controls)...
January 2024: Annals of Medicine and Surgery
https://read.qxmd.com/read/38216393/common-mental-disorders-and-perinatal-outcomes-in-victoria-australia-a-population-based-retrospective-cohort-study
#22
JOURNAL ARTICLE
Fiona Faulks, Kristina Edvardsson, Ingrid Mogren, Richard Gray, Beverley Copnell, Touran Shafiei
PURPOSE: Common mental disorders (non-psychotic mental health conditions which impact on day-to-day functioning) are increasingly common in childbearing women and may impact significantly on both maternal and neonatal outcomes. Our study examines the associations between common mental disorders and perinatal outcomes. METHODS: We used routinely collected perinatal data (2009-2016) for this population-based retrospective cohort study (n = 597,522 singleton births)...
January 11, 2024: Women and Birth
https://read.qxmd.com/read/38205973/investigating-ticagrelor-in-a-preclinical-pipeline-as-a-novel-therapeutic-to-prevent-preterm-birth
#23
JOURNAL ARTICLE
Bridget M Arman, Natalie K Binder, Natasha de Alwis, Sally Beard, Anjali Garg, Tu'uhevaha J Kaitu'u-Lino, Natalie J Hannan
Preterm birth remains a significant global health challenge, affecting approximately 10% of pregnancies and resulting in one million deaths globally every year. Tocolytic agents, used to manage preterm labour, have considerable limitations including lack of efficacy, and adverse side-effects, emphasising the urgent need for innovative solutions. Here, we explore repurposing an antiplatelet cardioprotective drug, ticagrelor, as a potential treatment to prevent preterm birth. Ticagrelor has demonstrated pleiotropic actions beyond platelet inhibition, including relaxant effects on smooth muscle cells and anti-inflammatory effects in models of diabetes and sepsis...
January 1, 2024: Reproduction
https://read.qxmd.com/read/38205102/study-of-caesarean-section-births-in-a-tertiary-care-hospital-in-mumbai-using-robson-classification-system
#24
JOURNAL ARTICLE
Hitendrasing Rajput, Pradnya Changede, Niranjan Chavan, Arun Nayak, Shikhanshi, Hera Mirza, Shalini Mahapatra
INTRODUCTION: Robson ten-group classification system is recommended by WHO (World health organization) as a global standard for assessment and monitoring caesarean section (CS) rates. This classification is simple and robust. It is prospective, easily reproducible and clinically relevant. METHODOLOGY: We conducted a prospective observational study of CS births at a tertiary care institute. Caesarean births in a tertiary care hospital were classified using Robson classification system as recommended by WHO...
December 2023: Journal of Obstetrics and Gynaecology of India
https://read.qxmd.com/read/38194878/comparison-of-maternal-fetal-obstetric-and-neonatal-outcomes-for-234-triplet-pregnancies-conceived-in-vivo-versus-ivf-and-icsi-conceptions
#25
JOURNAL ARTICLE
E M Pena-Burgos, I Duyos-Mateo, J J Pozo-Kreilinger, R M Regojo-Zapata, V Quirós-González, M De La Calle
RESEARCH QUESTION: Is there a difference in maternal, fetal, obstetric and neonatal outcomes for triplet pregnancies when comparing in vivo conceptions with those conceived by assisted reproductive technology (ART)? DESIGN: This single-centre, retrospective cohort study included all triplet pregnancies followed up at La Paz University Hospital, Madrid between 2000 and 2022. The characteristics of the pregnant women, and maternal, fetal, obstetric and perinatal outcomes were examined...
September 26, 2023: Reproductive Biomedicine Online
https://read.qxmd.com/read/38190772/human-placenta-releases-extracellular-vesicles-carrying-corticotrophin-releasing-hormone-mrna-into-the-maternal-blood
#26
JOURNAL ARTICLE
Nilanjana Paul, Kaushik Maiti, Zakia Sultana, Joshua J Fisher, Huiming Zhang, Nicole Cole, Terry Morgan, Roger Smith
The human placenta releases diverse extracellular vesicles (EVs), including microvesicles (100-1000 nm) and exosomes (30-150 nm), into the maternal blood for feto-maternal communication. Exosomes and microvesicles contribute to normal pregnancy physiology and major pregnancy pathologies. Differences in miRNA expressions and protein content in placental exosomes have been reported in complicated pregnancies. During human pregnancy, Corticotropin-Releasing Hormone (CRH) is produced and released by the placenta into the maternal blood...
January 5, 2024: Placenta
https://read.qxmd.com/read/38189187/pregnancy-outcomes-post-kidney-transplantation-across-23%C3%A2-years
#27
JOURNAL ARTICLE
Jessica Han, Ciara Anne McCormick, Anna Krelle, Paul Champion de Crespigny, Julia Unterscheider
BACKGROUND: Pregnancy in kidney transplant recipients has become increasingly common. However, pregnancy carries higher risks to these patients compared to the general population. AIMS: To describe pregnancy outcomes in kidney transplant recipients. MATERIALS AND METHODS: We conducted a single-centre retrospective cohort study of kidney transplant recipients who delivered after 20 weeks gestation at a quaternary hospital in Victoria, Australia, between 2000 and 2022 inclusive...
January 8, 2024: Australian & New Zealand Journal of Obstetrics & Gynaecology
https://read.qxmd.com/read/38186807/predictors-of-maternal-and-fetal-outcome-in-severely-anemic-pregnant-mothers-a-sequential-mixed-methods-study
#28
JOURNAL ARTICLE
V Saraswathy, M Subashini, R L Jayavani, Usha Vaithiyanathan, Reenaa Mohan, R Sindhuri
INTRODUCTION: Severe anemia in pregnancy increases maternal and neonatal morbidity and mortality in the antenatal period. OBJECTIVE: To find out the maternal and fetal outcomes in severely anemic pregnant women and explore the reason for the persistence of severe anemia in pregnant women. MATERIALS AND METHODS: Sequential explanatory mixed method study (Quan-Qual) was conducted in the Government Women and Children Hospital for a period of 1 and half years...
November 2023: Journal of Family Medicine and Primary Care
https://read.qxmd.com/read/38177278/evaluating-the-effect-of-maternal-non-communicable-disease-on-adverse-pregnancy-outcomes-and-birthweight-in-pakistan-a-facility-based-retrospective-cohort-study
#29
JOURNAL ARTICLE
Esther Wainwright, Irfan Sheikh, Rahat Qureshi, Sana Yousuf, Raheela Khan, Matthew Elmes
Non-communicable diseases (NCDs) claim 74% of global lives, disproportionately affecting lower and middle-income countries like Pakistan. NCDs may increase the risk of preterm birth (PTB), caesarean section (CS), and low birthweight. This study aims to determine whether the high prevalence of NCDs in Pakistan play a role in the high rates of preterm births, and CS. This retrospective cohort study from Aga Khan University Hospital, Pakistan, investigated effects of pre-existing NCDs on pregnancy outcomes of 817 pregnant women...
January 5, 2024: Scientific Reports
https://read.qxmd.com/read/38155905/pgf-2%C3%AE-induces-a-pro-labour-phenotypical-switch-in-human-myometrial-cells-that-can-be-inhibited-with-pgf-2%C3%AE-receptor-antagonists
#30
JOURNAL ARTICLE
Isabel Hamshaw, Anne Straube, Richard Stark, Laura Baxter, Mohammad T Alam, Walter J Wever, Jun Yin, Yong Yue, Philippe Pinton, Aritro Sen, Gregory D Ferguson, Andrew M Blanks
Preterm birth is the leading cause of infant morbidity and mortality. There has been an interest in developing prostaglandin F2α (PGF2α ) antagonists as a new treatment for preterm birth, although much of the rationale for their use is based on studies in rodents where PGF2α initiates labour by regressing the corpus luteum and reducing systemic progesterone concentrations. How PGF2α antagonism would act in humans who do not have a fall in systemic progesterone remains unclear. One possibility, in addition to an acute stimulation of contractions, is a direct alteration of the myometrial smooth muscle cell state towards a pro-labour phenotype...
2023: Frontiers in Pharmacology
https://read.qxmd.com/read/38154893/genital-tract-infections-the-vaginal-microbiome-and-gestational-age-at-birth-among-pregnant-women-in-south-africa-a-cohort-study-protocol
#31
JOURNAL ARTICLE
Ranjana M S Gigi, Mandisa M Mdingi, Hyunsul Jung, Shantelle Claassen-Weitz, Lukas Bütikofer, Jeffrey D Klausner, Christina A Muzny, Christopher M Taylor, Janneke H H M van de Wijgert, Remco P H Peters, Nicola Low
INTRODUCTION: Preterm birth complications are the most common cause of death in children under 5 years. The presence of multiple microorganisms and genital tract inflammation could be the common mechanism driving early onset of labour. South Africa has high levels of preterm birth, genital tract infections and HIV infection among pregnant women. We plan to investigate associations between the presence of multiple lower genital tract microorganisms in pregnancy and gestational age at birth...
December 28, 2023: BMJ Open
https://read.qxmd.com/read/38143986/comparing-obstetric-and-perinatal-outcomes-following-elective-and-emergency-cervical-cerclage-in-singleton-and-multiple-pregnancies%C3%A2-in-a-tertiary-care-perinatal-centre
#32
JOURNAL ARTICLE
Pushplata Kumari, Manish Kumar, Treasa Joseph, Minakshi Kumari, Bijesh Yadav, Manisha Madhai Beck
OBJECTIVE: To compare the success, failure rates and perinatal outcomes following emergency and elective cervical cerclage in singleton and twin pregnancies at a tertiary care perinatal centre over half a decade. METHODS: All pregnant women, both with singleton and twin pregnancies, who had cervical cerclage between June 2014 and May 2019 were included in the retrospective study. Success rates, failure rates, maternal complications and perinatal outcomes were compared in both groups...
December 2023: Journal of Obstetrics and Gynaecology of India
https://read.qxmd.com/read/38128388/mendelian-randomization-reveals-systemic-lupus-erythematosus-and-rheumatoid-arthritis-and-risk-of-adverse-pregnancy-outcomes
#33
JOURNAL ARTICLE
Peng Yan, Jiahuizi Yao, Ben Ke, Xiangdong Fang
BACKGROUND: The effect of systemic lupus erythematosus (SLE) and rheumatoid arthritis (RA) on adverse pregnancy outcomes is a controversial topic. This study aimed to use Mendelian randomization (MR) analysis to assess the causal relationship between SLE, RA and adverse pregnancy outcomes. METHODS: Genetic variants for SLE and RA, as well as adverse pregnancy outcomes, were derived from pooled statistics from large public genome-wide association studies. Several methods, such as inverse variance weighting (IVW), MR-Egger, weighted median and MR-Pleiotropic Residuals Sum and Outliers, were employed to estimate two-sample causality...
December 16, 2023: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://read.qxmd.com/read/38111450/study-of-cervical-mucus-cytology-and-serum-inflammatory-biomarkers-in-preterm-labour-compared-to-term-pregnancy-cases-in-a-tertiary-care-center-of-western-uttar-pradesh-up-india
#34
JOURNAL ARTICLE
Sweta Sinha, Shikha Seth, Priyanka Rai
PURPOSE: The onset of labor prior to 37 weeks of gestation is preterm labor. Incidence ranges from 5% to 7% of live births in developed countries, but higher in developing countries (10-13%). Preterm birth is a major threat in perinatal health care, as well as a risk factor for neurological impairment and disability. Considering that infection is the major risk factor for preterm labor in rural areas, this study was performed to assess the cytological changes in the cervical mucus of normal-term and preterm labor cases...
November 2023: Curēus
https://read.qxmd.com/read/38107788/multiple-pregnancies-the-myometrium-and-the-role-of-mechanical-factors-in-the-timing-of-labour
#35
JOURNAL ARTICLE
Sarah Arrowsmith
Multiple pregnancy remains a relatively common occurrence, but it is associated with increased risks of adverse outcomes for the mother and her babies and presents unique challenges to healthcare providers. This review will briefly discuss multiple pregnancies, their aetiology and their problems, including preterm birth, before reviewing the processes leading to normal labour onset and how they may be different in a multiple pregnancy. The mechanisms by which mechanical factors i.e., uterine distension or 'stretch' contribute to uterine excitability and the timing of labour onset will be the major focus, and how over distention may pre-dispose multiple pregnancies to preterm birth...
2023: Current research in physiology
https://read.qxmd.com/read/38073146/the-association-between-bacteriuria-and-adverse-pregnancy-outcomes-a-systematic-review-and-meta-analysis-of-observational-studies
#36
JOURNAL ARTICLE
Hans R W Piazzolla, Frederikke Modin, Sofie I Halkjær, Andreas M Petersen, Henrik Calum, Anne Holm
BACKGROUND: Antibiotics for bacteriuria and urinary tract infection are commonly prescribed during pregnancy to avoid adverse pregnancy outcomes. The aim of this study was to evaluate the association between significant bacteriuria in pregnancy and any of the four pregnancy outcomes: preterm delivery; low birth weight; small for gestational age; and preterm labour. METHODS: Systematic review with meta-analysis of observational studies. We searched PubMed, EMBASE, the Cochrane CENTRAL library, and Web of Science for observational studies published before 1 March 2022...
February 1, 2024: Journal of Antimicrobial Chemotherapy
https://read.qxmd.com/read/38052191/intrauterine-detection-of-ureaplasma-species-after-vaginal-colonization-in-pregnancy-and-neonatal-outcome
#37
JOURNAL ARTICLE
Judith Rittenschober-Boehm, Renate Fuiko, Alex Farr, Birgit Willinger, Angelika Berger, Katharina Goeral
INTRODUCTION: Intrauterine infection with Ureaplasma species (U.spp.) is mostly a result of vaginal colonization with subsequent ascending infection and is associated with adverse pregnancy outcome. Little is known about rates and risk factors for ascending infection. Aim of the current study was to analyse the frequency of ascending U.spp. infection in vaginally colonized pregnant women delivering preterm and subsequent short- and long-term outcome of infants. METHODS: Women delivering ≤32 weeks of gestation with available data on vaginal U...
December 5, 2023: Neonatology
https://read.qxmd.com/read/38037459/ambient-air-pollution-and-adverse-birth-outcomes-a-review-of-underlying-mechanisms
#38
JOURNAL ARTICLE
Julia C Fussell, Eric Jauniaux, Rachel B Smith, Graham J Burton
Epidemiological data provide varying degrees of evidence for associations between prenatal exposure to ambient air pollutants and adverse birth outcomes (suboptimal measures of fetal growth, preterm birth and stillbirth). To assess further certainty of effects, this review examines the experimental literature base to identify mechanisms by which air pollution (particulate matter, nitrogen dioxide and ozone) could cause adverse effects on the developing fetus. It likely that this environmental insult impacts multiple biological pathways important for sustaining a healthy pregnancy, depending upon the composition of the pollutant mixture and the exposure window owing to changes in physiologic maturity of the placenta, its circulations and the fetus as pregnancy ensues...
November 30, 2023: BJOG: An International Journal of Obstetrics and Gynaecology
https://read.qxmd.com/read/38016762/severe-hypocalcaemia-mimicking-acute-coronary-syndrome
#39
JOURNAL ARTICLE
Sahitya Allam, Ethan Kotloff, Anusha Bhat, Libin Wang
Hypocalcaemia is a common electrolyte deficiency that can be found in up to 28% of hospitalised patients. It may affect cardiac and smooth muscle tone, leading to ECG abnormalities and, in rare cases, coronary spasms and heart failure. This is a case of a pregnant woman in preterm labour who developed vasospastic angina and corrected QT interval (QTc) prolongation on ECG from severe hypocalcaemia, which likely occurred due to iatrogenic hypermagnesaemia. She had a negative diagnostic workup for acute coronary syndrome, and her chest pain and QTc prolongation ultimately resolved with intravenous electrolyte repletion...
November 28, 2023: BMJ Case Reports
https://read.qxmd.com/read/37996791/risk-factors-associated-with-preterm-birth-among-mothers-delivered-at-lira-regional-referral-hospital
#40
JOURNAL ARTICLE
Tom Etil, Bosco Opio, Bernard Odur, Charles Lwanga, Leonard Atuhaire
BACKGROUND: The World Health Organization (WHO) defines Preterm Birth (PTB) as "a live birth taking place before the expected 37 weeks of gestation". Annually, approximately 15 million infants are born prematurely, constituting significantly to infant mortality during the initial four weeks of life, responsible for 40% of deaths among children under the age of five. Evidently, preterm deliveries have contributed to 46% of admissions to the neonatal intensive care unit (NICU) at Lira Regional Referral Hospital (LRRH) over the past three years...
November 23, 2023: BMC Pregnancy and Childbirth
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