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https://www.readbyqxmd.com/read/29207782/prediction-of-delivery-in-women-with-threatening-preterm-labour-using-phosphorylated-insulin-like-growth-factor-binding-protein-1-and-cervical-length-using-transvaginal-ultrasound
#1
Amrita Kumari, Vandana Saini, P K Jain, Mamta Gupta
Introduction: Preterm delivery remains a challenge in Obstetrics as it is responsible for significant cause of perinatal morbidity and mortality. At present there is no standard test for prediction of preterm labour for timely referral to a center with NICU facilities. Aim: To evaluate the effectiveness of the cervical phosphorylated insulin like growth factor binding protein-1(phIGFBP-1), cervical length measurement and combination of phIGFBP-1 with cervical length for Predicting Preterm Labour (PTL)...
September 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/29197879/corticosteroid-induced-leukocytosis-in-pregnancy-a-prospective-observational-study
#2
H Y Voon, M S Leong, C W Li, A Bujang, H Suharjono
BACKGROUND: In the course of managing preterm labour, increasing trends of total white cell count raises concern for the obstetrician, suggesting a possible underlying infectious aetiology. Although mild leukocytosis is expected in pregnancy, the patterns of increment after corticosteroid administration are not well described beyond animal models and in a small number of human studies. METHODS: Seventy-three consecutive patients who required antenatal corticosteroids for either preterm labour or prelabour caesarean section were recruited and given a standard course of 12mg dexamethasone phosphate, twelve hours apart...
October 2017: Medical Journal of Malaysia
https://www.readbyqxmd.com/read/29194681/a-population-based-study-of-perinatal-infection-risk-in-women-with-and-without-systemic-lupus-erythematosus-and-their-infants
#3
Rachel A Bender Ignacio, Amy T Madison, Ata Moshiri, Noel S Weiss, Beth A Mueller
BACKGROUND: Increased risk of adverse birth outcomes is well described in women with systemic lupus erythematosus (SLE), but risk of maternal or infant infection in the peripartum period has not been well studied. We conducted a population-based cohort study of infection risk in women with and without SLE and their infants. METHODS: Linked birth-hospital discharge data identified 1297 deliveries to women with SLE and a 4:1 comparison cohort of deliveries to women without SLE in Washington State, 1987-2013...
December 1, 2017: Paediatric and Perinatal Epidemiology
https://www.readbyqxmd.com/read/29191725/bonding-in-neonatal-intensive-care-units-experiences-of-extremely-preterm-infants-mothers
#4
Isabel María Fernández Medina, José Granero-Molina, Cayetano Fernández-Sola, José Manuel Hernández-Padilla, Marcos Camacho Ávila, María Del Mar López Rodríguez
BACKGROUND: The birth of an extremely preterm infant can disrupt normal mother-infant physical contact and the care provided by the mother. This situation has an impact on the process of bonding between the mother and the child. AIM: The objective of this study was to describe and understand the experiences of mothers who have extremely preterm infants admitted in Neonatal Intensive Care Units with regard to their bonding process. METHODS: An interpretive, qualitative research methodology using Gadamer's philosophical hermeneutics was carried out...
November 27, 2017: Women and Birth: Journal of the Australian College of Midwives
https://www.readbyqxmd.com/read/29187760/the-exit-ex-utero-intrapartum-treatment-procedure-from-the-paediatric-ent-perspective
#5
B Pucher, J Szydlowski, K Jonczyk-Potoczna, J Sroczynski
The main principle of the EXIT procedure is to maintain uteroplacental circulation with neonatal anaesthesia by controlled uterine hypotonia. This enables securing the foetal airways and decompress or resect large neck and mediastinal foetal masses. The authors present their experience with use of the EXIT procedure in 7 foetuses in whom evaluation and management of the airways were performed. In 4 patients, the neck mass was surgically removed in the neonatal period, in 1 the propranolol treatment was introduced...
November 30, 2017: Acta Otorhinolaryngologica Italica
https://www.readbyqxmd.com/read/29183020/clinical-application-of-quantitative-foetal-fibronectin-for-the-prediction-of-preterm-birth-in-symptomatic-women
#6
Samara K Radford, Fabricio Da Silva Costa, Edward Araujo Júnior, Penelope M Sheehan
AIM: To evaluate the clinical application of the new Hologic quantitative foetal fibronectin (qfFN) bedside test for the prediction of spontaneous preterm birth (sPTB) in patients with symptoms suggestive of spontaneous threatened preterm labour (sPTL). METHODS: A prospective observational study with 154 pregnant women presenting signs and symptoms of sPTL was conducted. These women were subjected to a qfFN test between 22 and 35 weeks of gestation For each cut-off threshold, the ability to predict sPTB at within 14 days of conducting the test and <37 weeks was assessed by calculating the positive predictive value (PPV), negative predictive value (NPV), likelihood ratios, odds ratios, sensitivity, and specificity...
November 29, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/29181841/epidural-therapy-for-the-treatment-of-severe-pre-eclampsia-in-non-labouring-women
#7
REVIEW
Amita Ray, Sujoy Ray
BACKGROUND: Pre-eclampsia is a pregnancy-specific multi-organ disorder, which is characterised by hypertension and multisystem organ involvement and which has significant maternal and fetal morbidity and mortality. Failure of the placental vascular remodelling and reduced uteroplacental flow form the etiopathological basis of pre-eclampsia. There are several established therapies for pre-eclampsia including antihypertensives and anticonvulsants. Most of these therapies aim at controlling the blood pressure or preventing complications of elevated blood pressure, or both...
November 28, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29170287/maternal-and-neonatal-outcomes-of-vaginal-breech-delivery-for-singleton-term-pregnancies-in-a-carefully-selected-cameroonian-population-a-cohort-study
#8
Julius Sama Dohbit, Pascal Foumane, Joel Noutakdie Tochie, Fadimatou Mamoudou, Mazou N Temgoua, Ronni Tankeu, Veronica Aletum, Emile Mboudou
BACKGROUND AND OBJECTIVES: Vaginal breech delivery (VBD) is known to be associated with more perinatal and maternal complications. Very few studies on the subject have been carried out in poor-resource settings. The aim of this study was to determine maternal and neonatal outcomes in carefully selected cases of VBD for singleton term pregnancies in a tertiary centre in Cameroon. DESIGN: A retrospective cohort study. SETTING: A tertiary hospital in Yaounde, Cameroon...
November 22, 2017: BMJ Open
https://www.readbyqxmd.com/read/29168589/time-to-delivery-transfers-for-threatened-preterm-labour-and-prelabour-rupture-of-membranes-in-western-australia
#9
Jade Hollingworth, Rachel Pietsch, Mathias Epee-Bekima, Elizabeth Nathan
OBJECTIVE: To describe the outcomes of patients transferred to King Edward Memorial Hospital (KEMH) with signs of labour at preterm gestations. DESIGN: A retrospective observational study of the 69 cases transferred to KEMH during 2015. SETTING: Patient transfers from all locations across Western Australia (WA) to the sole tertiary perinatal centre in Perth. PARTICIPANTS: Pregnant women within WA with threatened or actual preterm labour (PTL) or preterm prelabour rupture of membranes (PPROM) between 23 and 32 weeks gestation...
November 23, 2017: Australian Journal of Rural Health
https://www.readbyqxmd.com/read/29132325/level-causes-and-risk-factors-of-stillbirth-a-population-based-case-control-study-from-chandigarh-india
#10
Ariarathinam Newtonraj, Manmeet Kaur, Madhu Gupta, Rajesh Kumar
BACKGROUND: Globally, India ranks first in the absolute number of stillbirths. Hence, the level, causes, and risk factors of stillbirths were estimated to facilitate designing of prevention strategy. METHODS: Capture and recapture method was used to identify 301 stillbirths from 1st July 2013 to 31st August 2014 in Chandigarh Union Territory of India. Verbal autopsies (n = 181) were done at household level to identify causes of stillbirths. Risk factors were determined using case-control approach...
November 13, 2017: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29114987/ivf-icsi-treatment-and-the-risk-of-spontaneous-preterm-birth-in-singleton-pregnancies-a-meta-analysis-of-cohort-studies
#11
REVIEW
Paolo Cavoretto, Massimo Candiani, Veronica Giorgione, Annalisa Inversetti, Matilda Marta Abu-Saba, Francesca Tiberio, Cristina Sigismondi, Antonio Farina
OBJECTIVES: Preterm birth (PTB) is more common among in-vitro fertilization (IVF) as compared to natural conception. However, the extent to which this it due to spontaneous labour or to iatrogenic indications has not been determined. This study quantifies the risk of spontaneous preterm birth (SPTB) in singleton pregnancies resulting from IVF as compared to spontaneous conception. METHODS: Web-based databases search (PubMed/Medline, Scopus, Web of Science) up to September 2017 identified articles comparing the risk of SPTB in singleton IVF/ICSI and naturally conceived pregnancies...
November 7, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29108135/regimens-of-ultrasound-surveillance-for-twin-pregnancies-for-improving-outcomes
#12
REVIEW
Jane G Woolcock, Rosalie M Grivell, Jodie M Dodd
BACKGROUND: Increased ultrasound surveillance of twin pregnancies has become accepted practice due to the higher risk of complications. There is no current consensus however as to the method and frequency of ultrasound monitoring that constitutes optimal care. OBJECTIVES: To systematically review the effects of different types and frequency of ultrasound surveillance for women with a twin pregnancy on neonatal, fetal and maternal outcomes. SEARCH METHODS: We searched Cochrane Pregnancy and Childbirth's Trials Register, ClinicalTrials...
November 7, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29100893/-late-preterm-infants-in-spain-experience-of-the-34-36-neonatal-group
#13
Mercedes García-Reymundo, Xavier Demestre, M José Calvo, Gemma Ginovart, Ana Jiménez, José Antonio Hurtado
INTRODUCTION: Late preterm (LP) infants (34 -36 weeks of gestation) are the largest group of preterm infants and also the least studied so far. In order to improve their care and reduce the impact of their increased morbidity and mortality, it is essential to know the current situation in Spain. POPULATION AND METHOD: Clinical-epidemiological variables of the LP population of 34 participating hospitals were prospectively collected from 1 April 2011 to 31 March 2016, and were then compared with the Minimum Perinatal Data Set for term births in the database...
October 31, 2017: Anales de Pediatría: Publicación Oficial de la Asociación Española de Pediatría (A.E.P.)
https://www.readbyqxmd.com/read/29096631/prediction-of-uncomplicated-pregnancies-in-obese-women-a-prospective-multicentre-study
#14
Matias C Vieira, Sara L White, Nashita Patel, Paul T Seed, Annette L Briley, Jane Sandall, Paul Welsh, Naveed Sattar, Scott M Nelson, Debbie A Lawlor, Lucilla Poston, Dharmintra Pasupathy
BACKGROUND: All obese pregnant women are considered at equal high risk with respect to complications in pregnancy and birth, and are commonly managed through resource-intensive care pathways. However, the identification of maternal characteristics associated with normal pregnancy outcomes could assist in the management of these pregnancies. The present study aims to identify the factors associated with uncomplicated pregnancy and birth in obese women, and to assess their predictive performance...
November 3, 2017: BMC Medicine
https://www.readbyqxmd.com/read/29095502/obstetric-outcomes-after-conservative-treatment-for-cervical-intraepithelial-lesions-and-early-invasive-disease
#15
REVIEW
Maria Kyrgiou, Antonios Athanasiou, Ilkka E J Kalliala, Maria Paraskevaidi, Anita Mitra, Pierre Pl Martin-Hirsch, Marc Arbyn, Phillip Bennett, Evangelos Paraskevaidis
BACKGROUND: The mean age of women undergoing local treatment for pre-invasive cervical disease (cervical intra-epithelial neoplasia; CIN) or early cervical cancer (stage IA1) is around their 30s and similar to the age of women having their first child. Local cervical treatment has been correlated to adverse reproductive morbidity in a subsequent pregnancy, however, published studies and meta-analyses have reached contradictory conclusions. OBJECTIVES: To assess the effect of local cervical treatment for CIN and early cervical cancer on obstetric outcomes (after 24 weeks of gestation) and to correlate these to the cone depth and comparison group used...
November 2, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/29076668/efficacy-of-two-regimens-of-dexamethasone-for-management-of-preterm-labour-pilot-study
#16
Ahsan Rasool, Umer Farooq, Qurat-Ul-Ann Nazir, Hira Bahar Durani
BACKGROUND: Dexamethasone is widely used for prevention of respiratory distress syndrome (RDS), necrotising enterocolitis (NEC) and intra-ventricular haemorrhage (IVH) in preterm babies; decreasing the neonatal mortality rate. There is no consensus on the dose of corticosteroid administered to the mother expected to have a preterm baby. This study is conducted to compare the effectiveness of two popular regimens of dexamethasone administration in decreasing incidence of RDS, necrotizing enterocolitis, IVH and neonatal mortality rate...
July 2017: Journal of Ayub Medical College, Abbottabad: JAMC
https://www.readbyqxmd.com/read/29062402/the-outcomes-of-pregnancy-and-childbirth-in-adolescents-in-slovenia
#17
Simona Korenčan, Bojana Pinter, Mojca Grebenc, Ivan Verdenik
INTRODUCTION: The objective of the study was to determine the course and outcomes of pregnancy and childbirth in adolescents compared to women aged 20-24 years in Slovenia. METHODS: In the retrospective study, the course of pregnancy and labour and the perinatal outcome of newborns in primiparous adolescents aged ≤19 years (study group) have been compared to the control group of primiparous women aged 20-24 years. The study group was further divided into a study subgroup of adolescents aged ≤17 years...
October 2017: Zdravstveno Varstvo
https://www.readbyqxmd.com/read/29057456/small-fetal-thymus-and-adverse-obstetrical-outcome-a-systematic-review-and-a-meta-analysis
#18
REVIEW
Claudia Caissutti, Alessandra Familiari, Asma Khalil, Maria E Flacco, Lamberto Manzoli, Giovanni Scambia, Angelo Cagnacci, Francesco D'antonio
INTRODUCTION: To explore the association between small fetal thymus on ultrasound and adverse obstetrical outcome. MATERIAL AND METHODS: Medline, Embase, Cochrane and Web of Science databases were searched. Primary outcome was the risk of preterm birth before 37 and 34 weeks of gestation in fetuses with, compared to those without, a small thymus on ultrasound. SECONDARY OUTCOMES: occurrence of chorioamnionitis, intrauterine growth restriction, neonatal sepsis, gestational age at birth, birthweight, neonatal morbidity and preeclampsia...
October 23, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28988892/the-il-1%C3%AE-signalling-pathway-and-its-role-in-regulating-pro-inflammatory-and-pro-labour-mediators-in-human-primary-myometrial-cells
#19
Martha Lappas
Interleukin (IL)-1β plays a central role in the processes of human labour and delivery. The adaptor proteins involved in the IL-1β signalling pathway in human myometrium are not known. This study sought to determine the role of the adaptor proteins myeloid differentiation primary response 88 (MyD88), tumour necrosis factor receptor-associated factor 6 (TRAF6), IL-1 receptor-associated kinase 4 (IRAK4) and transforming growth factor beta-activated kinase 1 (TAK1) in IL-1β-induced formation of pro-inflammatory and pro-labour mediators in human myometrium...
October 6, 2017: Reproductive Biology
https://www.readbyqxmd.com/read/28962692/expression-and-function-of-nod-like-receptors-by-human-term-gestation-associated-tissues
#20
Aled H Bryant, Ryan J Bevan, Samantha Spencer-Harty, Louis M Scott, Ruth H Jones, Catherine A Thornton
INTRODUCTION: Nucleotide-binding oligomerization domain (NOD)-like receptors or NOD-like receptors (NLRs) have been implicated in several disease pathologies associated with inflammation. Since local and systemic inflammation is a hallmark of both term and preterm labour, a role for NLRs at the materno-fetal interface has been postulated. METHODS: Gene expression and immunolocalisation of NLR family members in human placenta, choriodecidua, and amnion were examined...
October 2017: Placenta
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