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https://www.readbyqxmd.com/read/29903720/cord-milking-versus-immediate-clamping-in-preterm-infants-a-randomised-controlled-trial
#1
Walid El-Naggar, David Simpson, Arif Hussain, Anthony Armson, Linda Dodds, Andrew Warren, Robin Whyte, Douglas McMillan
OBJECTIVE: To investigate whether umbilical cord milking (UCM) at birth improves systemic blood flow and short-term outcomes, as compared with immediate cord clamping (ICC). DESIGN: Randomised clinical trial. SETTING: Single tertiary care centre. PATIENTS: Infants born to eligible women presenting in preterm labour between 24 and 31 weeks' gestation. INTERVENTIONS: UCM three times at birth or ICC...
June 14, 2018: Archives of Disease in Childhood. Fetal and Neonatal Edition
https://www.readbyqxmd.com/read/29900612/prevalence-antenatal-management-and-perinatal-outcomes-of-monochorionic-monoamniotic-twin-pregnancies-a-collaborative-multicentre-study-in-england-2000-2013
#2
Svetlana V Glinianaia, Judith Rankin, Asma Khalil, Julia Binder, Gareth Waring, Stephen N Sturgiss, Basky Thilaganathan, Therese Hannon
OBJECTIVES: To determine the prevalence of monochorionic monoamniotic (MCMA) twin pregnancies and to describe perinatal outcomes and clinical management of these pregnancies. METHODS: This multicentre cohort study used population-based data on MCMA twin pregnancies from 11 Northern Survey of Twin and Multiple Pregnancy (NorSTAMP) maternity units for the prevalence estimation of MCMA twinning. Pregnancy outcomes at <24 weeks' gestation, antenatal parameters and perinatal outcomes (from ≥24 weeks to the first 28 days of life) were analysed using combined data on pregnancies with confirmed MCMA chorionicity from the NorSTAMP and the Southwest Thames Region of London Obstetric Research Collaborative (STORK) multiple pregnancy cohort for 2000-2013...
June 13, 2018: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29895996/maternal-and-early-perinatal-outcomes-of-triplet-pregnancy-study-of-82-triplets-from-a-single-perinatal-centre-in-south-india
#3
Priya Rajan, Srinivas Murki, Suseela Vavilala, Nirupama Surubhotla
Objectives: To study the recent trends in maternal and perinatal outcomes of triplet pregnancy from a perinatal centre in South India. Methods: All triplet pregnancies booked at Fernandez hospital, Hyderabad (a tertiary care perinatal centre in South India), or those referred between 2000 and 2014 were included in the study. The maternal, fetal and neonatal outcome and any interventions like cerclage, steroid administration were studied. Results: There were 82 triplet deliveries over the study period of 15 years (82 per 69,584 live births)...
June 2018: Journal of Obstetrics and Gynaecology of India
https://www.readbyqxmd.com/read/29883518/the-immunoproteasome-inhibitor-onx-0914-regulates-inflammation-and-expression-of-contraction-associated-proteins-in-myometrium
#4
Stella Liong, Ratana Lim, Caitlyn Nguyen-Ngo, Gillian Barker, Helena C Parkington, Martha Lappas
There is currently no effective treatments to prevent spontaneous preterm labour. The precise upstream biochemical pathways that regulate the transition between uterine quiescence during pregnancy and contractility during labour remain unclear. It is well known however that intrauterine inflammation, including infection, is commonly associated with preterm labour. In this study, we identified the immunoproteasome subunit low-molecular-mass protein (LMP)7 mRNA expression to be significantly upregulated in labouring human myometrium...
June 8, 2018: European Journal of Immunology
https://www.readbyqxmd.com/read/29870831/management-of-pregnancy-based-on-healthcare-consumption-of-women-who-delivered-in-france-in-2015-contribution-of-the-national-health-data-system-snds
#5
Clara Piffaretti, Vincent Looten, Sylvie Rey, Jeanne Fresson, Anne Fagot-Campagna, Philippe Tuppin
OBJECTIVE: This study was designed to further our knowledge of the management of pregnant women based on the national health data system (SNDS). MATERIAL AND METHODS: Women covered by the national health insurance general scheme, who delivered in 2015. RESULTS: Among the 672,182 women included (mean age: 31 years, SD 5.3), 0.3% were under the age of 18 years, 4% lived in a French overseas department (<18 years: 21%), 17% had complementary universal health insurance coverage (<18 years: 75%), 1...
June 2, 2018: Journal of Gynecology Obstetrics and Human Reproduction
https://www.readbyqxmd.com/read/29860970/circulating-endothelial-progenitor-cells-in-pregnant-women-with-premature-rupture-of-membranes-potential-association-with-placental-disorders
#6
Simin Asadian, Vahid Siavashi, Masoumeh Jabarpour, Azam Sharifi, Masoumeh Esmaeilivand, Pirouz Pourmohammad, Seyed Mahdi Nassiri
The frequency of preterm labour has risen over the last few years. Plasma oestrogen concentrations differ between patients who deliver before term and those who deliver at term. Oestrogen can influence the kinetics of circulating endothelial progenitor cells (cEPCs). Here, we attempted to identify the potential association of cEPCs with the incidence of complications typical of prematurity. The study groups consisted of 60 pregnant women with premature rupture of membranes (PROM; less than 37 weeks) and 50 term pregnant women (more than 38 weeks)...
June 4, 2018: Reproduction, Fertility, and Development
https://www.readbyqxmd.com/read/29739438/automated-electrohysterographic-detection-of-uterine-contractions-for-monitoring-of-pregnancy-feasibility-and-prospects
#7
C Muszynski, T Happillon, K Azudin, J-B Tylcz, D Istrate, C Marque
BACKGROUND: Preterm birth is a major public health problem in developed countries. In this context, we have conducted research into outpatient monitoring of uterine electrical activity in women at risk of preterm delivery. The objective of this preliminary study was to perform automated detection of uterine contractions (without human intervention or tocographic signal, TOCO) by processing the EHG recorded on the abdomen of pregnant women. The feasibility and accuracy of uterine contraction detection based on EHG processing were tested and compared to expert decision using external tocodynamometry (TOCO) ...
May 8, 2018: BMC Pregnancy and Childbirth
https://www.readbyqxmd.com/read/29732148/effect-of-molecular-hydrogen-on-uterine-inflammation-during-preterm-labour
#8
Tomoko Nakano, Tomomi Kotani, Kenji Imai, Yukako Iitani, Takafumi Ushida, Hiroyuki Tsuda, Hua Li, Akira Iwase, Shinya Toyokuni, Fumitaka Kikkawa
Intrauterine inflammation causes preterm birth and is associated with complications in preterm neonates. Thus, strategies aimed at suppressing inflammation are expected to be effective for reducing the risk of preterm birth and associated complications. Our previous studies demonstrated that molecular hydrogen (H2 ), an anti-inflammatory agent, prevented inflammation-induced impairment in foetal brain and lung tissues in lipopolysaccharide (LPS)-induced rodent models. However, it remains unclear whether H2 is capable of inhibiting preterm labour...
May 2018: Biomedical Reports
https://www.readbyqxmd.com/read/29727785/gender-and-preterm-birth-is-male-fetal-gender-a-clinically-important-risk-factor-for-preterm-birth-in-high-risk-women
#9
P J Teoh, A Ridout, P Seed, R M Tribe, A H Shennan
Gender differences in several adverse pregnancy outcomes have been described, including preterm labour and delivery. In the low risk population, the male fetus is at significantly higher risk of spontaneous preterm birth. OBJECTIVES: Our objective was to examine the risk effect of fetal gender on pregnant women at higher risk of preterm birth, and therefore its potential impact on targeting management. STUDY DESIGN: This was an analysis of prospectively collected data from a dedicated inner-city Prematurity Surveillance Clinic over a sixteen-year period...
June 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29724667/preventing-preterm-birth-new-approaches-to-labour-therapeutics-using-nanoparticles
#10
REVIEW
Jonathan W Paul, Roger Smith
Preterm birth remains a major obstetric problem with ramifications that extend beyond immediate health and safety concerns for the newborn to include massive societal and economic burden. Although three quarters of preterm birth-related deaths could be prevented with cost-effective interventions, there has been little progress towards achieving sustained tocolysis that translates into improved outcomes for the newborn. With private enterprise reluctant to venture into the sphere of tocolysis, due to potential litigation, advances in the field may fall to new approaches using existing tocolytic resources more effectively...
April 13, 2018: Best Practice & Research. Clinical Obstetrics & Gynaecology
https://www.readbyqxmd.com/read/29719929/the-effect-of-parity-on-risk-of-complications-in-pregnant-women-with-epilepsy-a-population-based-cohort-study
#11
Kim C Danielsson, Ingrid Borthen, Nils E Gilhus, Nils H Morken
INTRODUCTION: Women with epilepsy have increased risk of complications in pregnancy with consequences for the mother and child. There are no studies on the influence of parity on complications in women with epilepsy. MATERIAL AND METHODS: This was a population-based cohort study of all first and second births in the Medical Birth Registry of Norway 1999-2013. Risks were estimated and complication rates were compared in distinct women with epilepsy treatment categories...
May 2, 2018: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/29708281/pharmacokinetics-safety-and-tolerability-of-obe022-a-selective-prostaglandin-f2%C3%AE-receptor-antagonist-tocolytic-a-first-in-human-trial-in-healthy-post-menopausal-women
#12
Oliver Pohl, Line Marchand, Jean-Pierre Gotteland, Simon Coates, Jörg Täubel, Ulrike Lorch
AIMS: Preterm birth remains a significant risk for later disability. The selective inhibition of the prostaglandin F2α receptor (FP) has significant advantages for a tocolytic. The pro-drug OBE022 and its metabolite OBE002 are novel FP antagonists under development for treating preterm labour. METHODS: We performed a prospective, first in human, Phase I, dose escalation, placebo-controlled, randomised trial at a clinical trial site in the UK. Placebo, single ascending doses (SAD) of 10, 30, 100, 300, 1000 or 1300 mg, and multiple ascending doses (MAD) over seven days of 100, 300 or 1000 mg per day; were administered to post-menopausal female volunteers...
April 30, 2018: British Journal of Clinical Pharmacology
https://www.readbyqxmd.com/read/29703848/should-empiric-antibiotic-therapy-be-withheld-when-aetiology-of-preterm-birth-is-non-infectious-a-protocol-for-a-systematic-review
#13
Joanna Seliga-Siwecka, Mohammed Toseef Ansari, Judy Aschner, Margaret Sampson, Justyna Romańska
INTRODUCTION: Preterm birth (PTB) at <37 weeks of gestation is the leading cause of perinatal morbidity and mortality in developed countries. The traditional approach has been based on the assumption that PTB is primarily a result of intrauterine infection, which triggers preterm labour and puts the newborn at risk of early onset sepsis (EOS). We are currently experiencing a rise in prematurity that results from maternal and fetal diseases unrelated to infection. We have designed a systematic review to assess whether chemoprophylaxis should be withheld when the aetiology of preterm birth is non-infectious...
April 27, 2018: BMJ Open
https://www.readbyqxmd.com/read/29695386/the-relationship-between-intimate-partner-violence-reported-at-the-first-antenatal-booking-visit-and-obstetric-and-perinatal-outcomes-in-an-ethnically-diverse-group-of-australian-pregnant-women-a-population-based-study-over-10-years
#14
Hannah Grace Dahlen, Ana Maria Munoz, Virginia Schmied, Charlene Thornton
OBJECTIVES: Intimate partner violence (IPV) is a global health issue affecting mainly women and is known to escalate during pregnancy and impact negatively on obstetric and perinatal outcomes. The aim of this study is to determine the incidence of IPV in a pregnant multicultural population and to determine the relationship between IPV reported at booking interview and maternal and perinatal outcomes. DESIGN: This is a retrospective population-based data study. We analysed routinely collected data (2006-2016) from the ObstetriX system on a cohort of pregnant women...
April 25, 2018: BMJ Open
https://www.readbyqxmd.com/read/29682558/dream-is-involved-in-the-genesis-of-inflammation-induced-prolabour-mediators-in-human-myometrial-and-amnion-cells
#15
Priyanka Goradia, Ratana Lim, Martha Lappas
Preterm birth is the primary cause of perinatal morbidity and mortality worldwide. Inflammation induces a cascade of events leading to preterm birth by activating nuclear factor- κ B (NF- κ B). In nongestational tissues, downstream regulatory element antagonist modulator (DREAM) regulates NF- κ B activity. Our aims were to analyse DREAM expression in myometrium and fetal membranes obtained at term and preterm and to determine the effect of DREAM inhibition on prolabour mediators in primary myometrial and amnion cells...
2018: BioMed Research International
https://www.readbyqxmd.com/read/29676341/the-prevalence-and-risk-factors-for-trichomonas-vaginalis-infection-amongst-human-immunodeficiency-virus-infected-pregnant-women-attending-the-antenatal-clinics-of-a-university-teaching-hospital-in-lagos-south-western-nigeria
#16
Olaolopin Ijasan, Kehinde Sharafadeen Okunade, Ayodeji Ayotunde Oluwole
Background: Trichomonas vaginalis infection is the most prevalent non-viral sexually transmitted infection worldwide. Interactions between this infection and human immunodeficiency virus (HIV) may cause adverse pregnancy outcomes such as preterm labour, premature rupture of membranes, chorioamnionitis, low birth weight and post-abortal sepsis. Aims: This study was aimed to determine the prevalence and risk factors of T. vaginalis infection amongst HIV-positive pregnant women attending antenatal care at the Lagos University Teaching Hospital (LUTH), Lagos, Nigeria...
January 2018: Nigerian Postgraduate Medical Journal
https://www.readbyqxmd.com/read/29674373/study-protocol-quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-2-uk-prospective-cohort-study
#17
Sarah Jane Stock, Lisa M Wotherspoon, Kathleen Anne Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben Mol, Richard D Riley, John Norrie, Jane Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (fFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts, USA) which quantifies fFN in a vaginal swab. In QUIDS part 2, we will perform a prospective cohort study in at least eight UK consultant-led maternity units, in women with symptoms of preterm labour at 22+0  to 34+6 weeks gestation to externally validate a prognostic model developed in QUIDS part 1...
April 19, 2018: BMJ Open
https://www.readbyqxmd.com/read/29627817/quantitative-fibronectin-to-help-decision-making-in-women-with-symptoms-of-preterm-labour-quids-part-1-individual-participant-data-meta-analysis-and-health-economic-analysis
#18
Sarah J Stock, Lisa M Wotherspoon, Kathleen A Boyd, Rachel K Morris, Jon Dorling, Lesley Jackson, Manju Chandiramani, Anna L David, Asma Khalil, Andrew Shennan, Victoria Hodgetts Morton, Tina Lavender, Khalid Khan, Susan Harper-Clarke, Ben W Mol, Richard D Riley, John Norrie, Jane E Norman
INTRODUCTION: The aim of the QUIDS study is to develop a decision support tool for the management of women with symptoms and signs of preterm labour, based on a validated prognostic model using quantitative fetal fibronectin (qfFN) concentration, in combination with clinical risk factors. METHODS AND ANALYSIS: The study will evaluate the Rapid fFN 10Q System (Hologic, Marlborough, Massachusetts) which quantifies fFN in a vaginal swab. In part 1 of the study, we will develop and internally validate a prognostic model using an individual participant data (IPD) meta-analysis of existing studies containing women with symptoms of preterm labour alongside fFN measurements and pregnancy outcome...
April 7, 2018: BMJ Open
https://www.readbyqxmd.com/read/29623863/-fibronectin-test-in-threatened-preterm-labour-cost-saving-but-not-yet-widely-implemented-in-the-netherlands
#19
T M S van Winden, M M C Bruijn, M A Oudijk, G J van Baaren, A H L C van Kaam, B W J Mol, M Kok
OBJECTIVE: Analysis of national implementation of the foetal fibronectin test in the diagnostics of threatened preterm labour in the Netherlands, and indication of the possible obstacles and consequences of implementation or no implementation. DESIGN: National questionnaire, retrospective cohort study and cost-effectiveness calculation. METHODS: We approached all hospitals in the Netherlands (n = 86) with a questionnaire on use of the fibronectin test...
2018: Nederlands Tijdschrift Voor Geneeskunde
https://www.readbyqxmd.com/read/29602171/appendicectomy-during-pregnancy-and-the-risk-of-preterm-birth-a-population-data-linkage-study
#20
Ibinabo Ibiebele, Margaret Schnitzler, Tanya Nippita, Jane B Ford
BACKGROUND: Suspected appendicitis is a common non-obstetric indication for emergency abdominal surgery during pregnancy. AIMS: Assess the risk of preterm birth and other maternal and neonatal adverse birth outcomes following appendicectomy during pregnancy. MATERIALS AND METHODS: Population-based data linkage study of women with singleton births in New South Wales, Australia, 2002-2014. Pregnancies with appendicitis and appendicectomy were compared to pregnancies without appendicitis...
March 30, 2018: Australian & New Zealand Journal of Obstetrics & Gynaecology
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