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Papatya Bayrak Degirmenci, Cengiz Kırmaz, Seda Vatansever, Ece Onur, Emine Nal, Soner Erdin, Beyhan Ozyurt
AIM: To contribute to the understanding of the pathogenesis of chronic spontaneous urticaria (CSU) by identifying its relationship with autoimmunity and cytokines using the autologous serum skin test (ASST) and peripheral blood mononuclear cell culture (PBMC) method. MATERIAL AND METHODS: Interleukins (IL)-4, IL-10, transforming growth factor (TGF-β1), interferon (IFN)-γ, IL-17A, and IL-23 levels in cell supernatants obtained by the PBMC method were measured using ELISA...
February 2017: Postȩpy Dermatologii i Alergologii
Hakki Yilmaz, M Cakmak, B Ceydilek, C Demir, A Aktas
OBJECTIVE: Interleukin-35 (IL-35), an interleukin-12 (IL-12) cytokine family member, is shown to be a potent immunosuppressive and anti-inflammatory cytokine. Inducible regulatory T cells (Tregs) produce IL-35 that mediates the immune inhibitory function of Tregs. Growing evidence revealed that upregulation of IL-35 expression may play a critical role in the prevention of autoimmune diseases in various experimental autoimmunity models and vice versa. Hashimoto's thyroiditis (HT) is considered to be a Treg cell-related autoimmune disease with loss of self-tolerance...
April 2016: Endocrine Regulations
Lynn Gerber, Michael Estep, Maria Stepanova, Carey Escheik, Ali Weinstein, Zobair M Younossi
BACKGROUND & AIMS: Fatigue is a disturbing symptom of chronic hepatitis C virus (HCV) infection. We assessed the effects of sustained virologic response 12 weeks after the end of therapy (SVR12) on fatigue. METHODS: We performed a retrospective analysis of 100 patients with chronic HCV infection who achieved an SVR12 after treatment with ledipasvir and sofosbuvir, with or without ribavirin. Data were collected on fatigue-related patient-reported outcomes (PROs) and assessed by using the Functional Assessment of Cancer Therapy-Fatigue scoring system and the Vitality subscale of Short Form 36...
January 2016: Clinical Gastroenterology and Hepatology
Sümeyra Nergiz Avcıoğlu, Selda Demircan Sezer, Mert Küçük, Emre Zafer, Hasan Yüksel, Barıs Akcan, Ozan Turgut
OBJECTIVE: This study aimed to investigate maternal serum concentrations of s-Endoglin and compare s-Endoglin with other inflammatory markers in prediction of time to delivery, in pregnancies complicated by preterm premature rupture of membranes (PPROM). MATERIALS AND METHODS: Fifty five patients complicated by PPROM whose gestational age were between 2433 weeks and 44 matched healthy pregnant women were included in present study. Maternal concentrations of s-Endoglin concentrations were measured by an enzyme-linked immunosorbent assay (ELISA) and compared with maternal inflammatory markers including interleukin-6 (IL-6), white blood cell (WBC) count and serum C-reactive protein (CRP)...
2016: Journal of Maternal-fetal & Neonatal Medicine
Kana Unuma, Toshihiko Aki, Takeshi Funakoshi, Kyoko Hashimoto, Koichi Uemura
Sepsis/endotoxemia is elicited by the circulatory distribution of pathogens/endotoxins into whole bodies, and causes profound effects on human health by causing inflammation in multiple organs. Mitochondrial damage is one of the characteristics of the cellular degeneration observed during sepsis/endotoxemia. Elimination of damaged mitochondria through the autophagy-lysosome system has been reported in the liver, indicating that autophagy should play an important role in liver homeostasis during sepsis/endotoxemia...
2015: Autophagy
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No abstract text is available yet for this article.
February 2015: Journal of Crohn's & Colitis
Nicholas Sitaras, José Carlos Rivera, Baraa Noueihed, Milsa Bien-Aimé, Karine Zaniolo, Samy Omri, David Hamel, Tang Zhu, Pierre Hardy, Przemyslaw Sapieha, Jean-Sébastien Joyal, Sylvain Chemtob
Ischemic retinopathies are characterized by sequential vaso-obliteration followed by abnormal intravitreal neovascularization predisposing patients to retinal detachment and blindness. Ischemic retinopathies are associated with robust inflammation that leads to generation of IL-1β, which causes vascular degeneration and impairs retinal revascularization in part through the liberation of repulsive guidance cue semaphorin 3A (Sema3A). However, retinal revascularization begins as inflammation culminates in ischemic retinopathies...
February 2015: American Journal of Pathology
Megha S Saraswat, Veeranjaneyulu Addepalli, Mukul Jain, Vishwanath D Pawar, Rakesh B Patel
BACKGROUND: Hypertensive nephropathy is moving up the charts to number 2 after diabetic nephropathy in terms of diagnostic frequency cited as causing end stage renal disease (ESRD). METHOD: Hypertensive nephropathy was produced in mildly hypertensive C57BL/6-(hREN)/(hAGT) double transgenic (dTG) mice with 20 mg/kg of cyclosporine A (CsA) administered subcutaneously (sc) daily for 28 days. CsA dose 20 mg/kg was selected for the study as this dose offered significant alteration in blood pressure, biochemical parameters and moderate nephropathy in kidney...
February 2014: Pharmacological Reports: PR
Hiromichi Ohtsuka, Hiroki Kobayashi, Kumi Kinouchi, Miki Kiyono, Yousuke Maeda
Japanese Black (JB) calves are more susceptible to infectious diseases compared to Holstein (Hol) calves. To clarify the immunological differences between JB and Hol calves, expression of cytokine messenger RNA (mRNA) was examined using peripheral CD4(+) , CD8(+) and γδ T cells. Healthy calves, 24 from each species, were examined. Blood samples were obtained from calves at 1 week, 1 month and 3 months old, eight calves for each age of each species. Peripheral blood mononuclear cells were stimulated with phytohemagglutin (PHA), and T cell subsets were isolated by positive selection using magnetic cell sorting (MACS)...
May 2014: Animal Science Journal, Nihon Chikusan Gakkaihō
Ayako Aoki-Yoshida, Kasumi Ichida, Reiji Aoki, Toshiyuki Kawasumi, Chise Suzuki, Yoshiharu Takayama
The anti-inflammatory effects of lactic acid derivatives were investigated on ultraviolet B (UVB)-irradiated HaCaT human keratinocytes. A pretreatment with indole-3-lactic acid (ILA) and 4-hydroxyphenyllactic acid (HPLA) inhibited the UVB-induced production of interlekin-6 (IL-6). The inhibitory effect of L-HPLA was equivalent to that of a corresponding racemic mixture (DL-HPLA), suggesting that optical isomerism did not affect the anti-inflammatory activity of HPLA.
2013: Bioscience, Biotechnology, and Biochemistry
Kun-Young Kwon, Hye-Ra Jung, Ilseon Hwang, Won-Il Choi
BACKGROUND: We investigated effects of short- and long-term exposure to sidestream smoke on the bronchiolar and alveolar cells in Sprague-Dawley rats. METHODS: RATS WERE DIVIDED INTO FIVE EXPERIMENTAL GROUPS: groups 1, 2, and 3 (1-month exposure to 3, 5, and 7 cigarettes a day, respectively), groups 4 and 5 (3- and 6 month exposure to five cigarettes a day, respectively). We examined the morphologic changes, the expressions of tumor necrosis factor α (TNF-α), tumor growth factor β1 (TGF-β1), interlekin (IL)-1α, IL-1β, Ki-67, and cytokeratin 14 and in situ apoptosis in the bronchiolar and alveolar cells on light microscopy (LM) and electron microscopic (EM) terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) staining...
April 2012: Korean Journal of Pathology
V Arora, J Verma, V Marwah, A Kumar, D Anand, N Das
OBJECTIVE: The phenotype of systemic lupus erythematosus (SLE) in Asian Indians is more severe as compared with that in Caucasians. The reason is not clear. In this context, we studied serum levels of interferon-gamma (IFN-γ), tumor necrosis factor-alpha (TNF-α), interleukin-4 (IL-4) and interlekin-10 (IL-10). Their interrelations and correlation with SLEDAI scores were evaluated. MATERIALS AND METHODS: Forty patients with active SLE and 40 controls were studied...
May 2012: Lupus
Ankit Shah, Anil Kumar
BACKGROUND: The exact mechanism underlying HIV-associated neurocognitive disorders still remains largely unresolved. However, viral genes (for example gp120 and tat) and their effect on cytokine/chemokine expressions have been linked with neuroinflammation. Conversely, interlekin-8 (IL-8) is a known proinflammatory chemokine and is known to be over-expressed in human brain microvascular endothelial cells in response to gp120. In this study, we sought to address whether HIV-1gp120 could affect IL-8 expression in astrocytes and whether the NF-κB pathway is involved in this phenomenon...
2010: Journal of Neuroinflammation
Christos C Zouboulis
Tissue inflammation is a major component of the acne process. Leukotriene B(4) (LTB(4)) is considered to be a major player in the development of tissue inflammation. Synthesis of LTB(4) is controlled by the enzyme 5-lipoxygenase. Since Zileuton blocks the activity of 5-lipoxygenase, experimental and clinical studies have been conducted to test mode of function, as well as efficacy and safety of this compound in the treatment of acne vulgaris. Human SZ95 sebocytes and inflammatory cells in vitro express the enzymes of the leukotriene pathway at mRNA and protein levels and enzymes involved in the biosynthesis of LTB(4) are activated in sebaceous glands of acne lesions...
May 2009: Dermato-endocrinology
Mir Davood Omrani, Mohammad Reza Mokhtari, Morteza Bagheri, Pedram Ahmadpoor
INTRODUCTION: Single nucleotide polymorphisms within promoter or other regulatory sequences of cytokine genes mainly influence the level of production and secretion of proteins. A large amount of evidence has shown that cytokine gene variations alter graft survival length after kidney transplantation. We studied the association of gene polymorphisms in the interlekin-10 gene (IL10; -1082 G/A), interferon-gamma gene (IFNG; +874 T/A), transforming growth factor-beta gene (TGFB; +869 T/C), and tumor necrosis factor-alpha gene (TNFA; -308 A/G) with kidney allograft survival...
April 2010: Iranian Journal of Kidney Diseases
Will Foster, David Carruthers, Gregory Y H Lip, Andrew D Blann
Tumour necrosis factor alpha (TNF-alpha) and interlekin-6 (IL-6) are key inflammatory cytokines in the pathogenesis of rheumatoid arthritis (RA), a disease also associated with endothelial perturbation and increased serum levels of adhesion molecules. As relationships between these processes and molecules are unclear, we tested the hypotheses (a) that TNF-alpha and IL-6 are linked to endothelial activation/damage and levels of soluble adhesion molecules, and (b) that intensive anti-inflammatory treatment improves levels of these indices...
May 2010: Journal of Thrombosis and Thrombolysis
Yong-tao Zhou, Jin-fang Yang, Yan-li Zhang, Xing-yu Wang, Piu Chan
Parkinson's disease is the second most common neurodegenerative disorders after Alzheimer's disease in the elderly. Abundant evidence showed that proinflammatory factors were involved in the pathogenesis of sporadic Parkinson's disease (SPD). Interleukin-1 (IL-1) is a cytokine that plays an important role in neurodegenerative disease. Previous association studies between genetic polymorphisms of IL-1 alpha and PD have showed conflicting results and no such study was done in Chinese. We recruited 533 SPD patients and 530 controls in Chinese Han population to investigate the association of IL-1alpha C-899T allele and risk for PD...
November 7, 2008: Neuroscience Letters
Nancy L Brackett, Daniel R Cohen, Emad Ibrahim, Teodoro C Aballa, Charles M Lynne
Men with spinal cord injury (SCI) have a unique semen profile characterized by normal sperm concentrations but abnormally low sperm motility. Previous studies showed that elevated concentrations of cytokines in the seminal plasma of these men contribute to this condition. For example, when elevated concentrations of interlekin-1beta (IL-1beta), IL-6, and tumor necrosis factor-alpha (TNF-alpha) were immunoneutralized in the semen of men with SCI, sperm motility improved. The present study investigated if these cytokines act on sperm cell receptors to inhibit sperm motility...
September 2007: Journal of Andrology
M Khassawneh, W A Hayajneh, H Kofahi, Y Khader, Z Amarin, A Daoud
This clinical study was conducted to evaluate the diagnostic value of C-reactive protein (CRP), interlekin-6 (IL-6) and immunoglobulin M (IgM) in the early diagnosis of neonatal sepsis. The diagnostic values of each marker separately or in combinations were evaluated. The optimal cut-off values of each marker in the diagnosis of neonatal sepsis were defined. Between December 2004 and March 2005, a total of 78 neonates at different ages with different diagnoses in a neonatal intensive care unit in North Jordan were enrolled...
February 2007: Scandinavian Journal of Immunology
Silvana Tasca, Giuseppe Tambussi, Silvia Nozza, Brunella Capiluppi, Maria Raffaella Zocchi, Laura Soldini, Fabrizio Veglia, Guido Poli, Adriano Lazzarin, Claudio Fortis
OBJECTIVE: To verify whether the in vitro sensitivity of immature dendritic cells (iDC) to lysis by autologous natural killer (NK) cells from HIV-infected individuals might be correlated with HIV disease progression. DESIGN: Both dendritic cells (DC) and interlekin (IL)-2 activated NK cells were obtained from 13 HIV-infected individuals early after seroconversion and not receiving highly active antiretroviral therapy (HAART) and from 14 individuals with chronic HIV infection under HAART...
November 7, 2003: AIDS
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