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https://www.readbyqxmd.com/read/28550795/thrombocytopenia-associated-with-tavi-the-summary-of-possible-causes
#1
REVIEW
Maciej Mitrosz, Malgorzata Chlabicz, Katarzyna Hapaniuk, Karol A Kaminski, Bozena Sobkowicz, Jaroslaw Piszcz, Slawomir Dobrzycki, Wlodzimierz J Musial, Tomasz Hirnle, Agnieszka M Tycinska
Thrombocytopenia (TP) following transcatheter aortic valve implantation (TAVI) procedure is a common phenomenon but the underlying mechanisms are neither well known nor described. Postinterventional severe TP is related to worse early and late outcome. Moreover, the statement of enhanced platelet and coagulation activation might justify even stronger antiplatelet and anticoagulation therapy following TAVI procedure. Thus, the examination of the pathomechanisms responsible for TP post TAVI seems to be crucial...
May 24, 2017: Advances in Medical Sciences
https://www.readbyqxmd.com/read/28550763/mechanical-properties-of-a-nanoporous-membrane-used-in-implantable-medical-devices-correlation-between-experimental-characterization-and-2d-numerical-simulation
#2
F Cristofari, B Piotrowski, R Pesci
Nanoporous membranes are used for the elaboration of implantable medical devices. In order to guaranty their integrity after implantation in a patient body, it is necessary to characterize the microstructure and the mechanical behavior of such membranes. They present randomly distributed pores around 1µm in diameter at the surface. X-ray nanotomography permits to get the geometry of the pores through the thickness with a reduction of the diameter in the core. A multiscale study is done to characterize the membranes: macroscopic tensile tests permit to get the behavior law of the non porous material and in situ tensile tests are carried on in a Scanning Electron Microscope in order to observe the evolution of pores and cracks during loading...
May 18, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28550588/value-of-ct-signs-and-measurements-as-a-predictor-of-pulmonary-hypertension-and-mortality-in-symptomatic-severe-aortic-valve-stenosis
#3
Matthias Eberhard, Monika Mastalerz, Jovana Pavicevic, Thomas Frauenfelder, Fabian Nietlispach, Francesco Maisano, Felix C Tanner, Thi Dan Linh Nguyen-Kim
To assess the value of computed tomography (CT) for non-invasive detection of pulmonary hypertension (PH) in patients with severe aortic stenosis undergoing transcatheter aortic valve implantation (TAVI) and to correlate CT measurements and signs with mortality after TAVI. 257 TAVI patients (median 84 years; 134 females) with both right heart catheterisation (RHC) and CT within 3 days were retrospectively analyzed. According to guidelines PH was defined as mean pulmonary artery pressure ≥25 mmHg in RHC. CT-signs for PH assessment were evaluated...
May 26, 2017: International Journal of Cardiovascular Imaging
https://www.readbyqxmd.com/read/28550428/partial-component-retained-two-stage-reconstruction-for-chronic-infection-after-uncemented-total-hip-arthroplasty-results-of-sixteen-cases-after-five-years-of-follow-up
#4
Kun-Hui Chen, Shang-Wen Tsai, Po-Kuei Wu, Cheng-Fong Chen, Hsin-Yi Wang, Wei-Ming Chen
PURPOSE: Two-stage reconstruction with total implant removal and re-implantation after infection control is considered the gold standard treatment for infection after hip arthroplasty. However, removal of the well-fixed stem or cup may cause substantial bone loss and other complications, thereby making reconstruction difficult. We evaluated whether an infection post total hip arthroplasty can be treated without removal of the radiographically and clinically well-fixed femoral stem or acetabular cup...
May 27, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28550426/clinical-radiological-and-survivorship-results-after-ten%C3%A2-years-comparing-navigated-and-conventional-total-knee-arthroplasty-a-matched-pair-analysis
#5
Clemens Baier, Jochen Wolfsteiner, Franziska Otto, Florian Zeman, Tobias Renkawitz, Hans-Robert Springorum, Günther Maderbacher, Joachim Grifka
PURPOSE: Our aim was to compare the long-term outcome between navigated and conventional total knee arthroplasty (TKA), which is currently not known. METHODS: Long-term survivorship, clinical scores and radiographic results of a matched-pair group of 350 patients (350 knees) treated with navigated (n = 157) or conventional (n = 188) TKA for osteoarthritis over a period of 11 years were reviewed retrospectively. RESULTS: The mean clinical follow-up was ten years...
May 26, 2017: International Orthopaedics
https://www.readbyqxmd.com/read/28550394/laparoscopic-paraesophageal-hernia-repair-utilization-rates-of-mesh-in-the-usa-and-short-term-outcome-analysis
#6
Francisco Schlottmann, Paula D Strassle, Marco G Patti
BACKGROUND: Many studies have shown that the utilization of mesh for paraesophageal hernia repair (PEHR) does not prevent recurrence. The aims of this study were (a) to assess the utilization of mesh for PEHR in the USA and (b) to compare the perioperative outcomes between PEHR with and without mesh. METHODS: A retrospective population-based analysis was performed using the American College of Surgeons National Surgical Quality Improvement Program (NSQIP) database...
May 26, 2017: Journal of Gastrointestinal Surgery: Official Journal of the Society for Surgery of the Alimentary Tract
https://www.readbyqxmd.com/read/28549918/percutaneous-pulmonary-melody-%C3%A2-valve-implantation-in-small-conduits
#7
Myriam Bensemlali, Sophie Malekzadeh-Milani, Meriem Mostefa-Kara, Damien Bonnet, Younes Boudjemline
BACKGROUND: The Melody(®) pulmonary valve has received approval for the treatment of dysfunctional right ventricular (RV) outflow tract conduits ≥16mm. AIMS: To investigate technical and clinical outcomes in patients who underwent percutaneous pulmonary valve implantation (PPVI) in conduits ≤16mm. METHODS: Eleven patients were enrolled retrospectively between 2000 and 2015 in a cardiac referral centre. RESULTS: The PPVI indications were obstruction (n=5); regurgitation (n=1); and mixed lesions (n=5)...
May 23, 2017: Archives of Cardiovascular Diseases
https://www.readbyqxmd.com/read/28549773/cochlear-implantation-in-patients-with-otosclerosis-of-the-otic-capsule
#8
Jay Burmeister, Susan Rathgeb, Jacques Herzog
OBJECTIVE: To evaluate outcomes of cochlear implantation of patients with otosclerosis of the otic capsule. STUDY DESIGN: A retrospective case series of 6 patients (7 ears). PATIENTS: 6 patients (7 ears), 5 patients with severe to profound sensorineural hearing loss; 1 patient with mild to profound sensorineural hearing loss, with radiologic evidence of otosclerosis. All patients were adult males, with or without history of stapes surgery...
May 19, 2017: American Journal of Otolaryngology
https://www.readbyqxmd.com/read/28549710/complication-rates-observed-in-silicone-and-polyurethane-catheters-of-totally-implanted-central-venous-access-devices-implanted-in-the-upper-arm
#9
Jasmin D Busch, Maren Vens, Catherine Mahler, Jochen Herrmann, Gerhard Adam, Harald Ittrich
PURPOSE: To present frequency and types of complications related to silicone (SI) versus polyurethane (PUR) catheters of totally implanted venous access devices (TIVADs) placed in the upper arm. MATERIAL AND METHODS: A cohort of 2,491 consecutive patients with TIVADs implanted between 2006 and 2015 was retrospectively analyzed. Complications were classified according to SIR guidelines. Pearson χ(2) test was used for categorical variables, and Student t test was used for continuous variables...
May 24, 2017: Journal of Vascular and Interventional Radiology: JVIR
https://www.readbyqxmd.com/read/28549683/findings-from-the-experience-with-the-punch-technique-for-auditory-osseointegrated-implants-a-retrospective-single-center-comparative-study
#10
Alfonso Bonilla, Carlos Magri, Eulalia Juan
OBJECTIVE: To compare the punch technique and linear incision with soft tissue reduction for the placement of auditory osseointegrated implants (AOI) and analyze results of osseointegration obtained with the punch technique as measured with the Implant Stability Quotient (ISQ). METHODS: Case review of 34 patients who received auditory osseointegrated implants between January 2010 and July 2015 and were divided into two groups according to the surgical technique: 18 with the punch technique (PT) and 16 with the linear incision technique (LI)...
May 23, 2017: Acta Otorrinolaringológica Española
https://www.readbyqxmd.com/read/28549630/-the-successful-saga-of-percutaneous-pulmonary-valvulation-in-congenital-heart-diseases
#11
Sophie Malekzadeh-Milani, Younes Boudjemline
With new surgical techniques, more and more complex congenital heart defects are treated requiring sometimes right ventricle to pulmonary artery conduit implantation. In order to extend RV to PA conduit lifespan, 15 years ago a valved stent was developed. The implantation technique was progressively standardized to decrease risks of procedural complications. Medium and long-term hemodynamic results of the stent were so good that indications were broadened to native or complex right ventricular outflow tracts...
May 23, 2017: La Presse Médicale
https://www.readbyqxmd.com/read/28549587/neuronally-differentiated-adipose-derived-stem-cells-and-aligned-phbv-nanofiber-nerve-scaffolds-promote-sciatic-nerve-regeneration
#12
Feihu Hu, Xiaofeng Zhang, Haixia Liu, Peng Xu, Doulathunnisa, Gaojun Teng, Zhongdang Xiao
Through a combination of biomaterials and stem cells, tissue engineering strategies for restoring and regenerating damaged peripheral nerves have recently been used to meet the challenges posed by nerve injury. In a previous study, we revealed a new way to induce neuronal differentiation of stem cells based on the temporally sequential use of miR-218 and Fibroblast Growth Factor 2 (FGF2) in vitro (FGF2-miR-218 induction approach). In the present study, we sought to investigate the application of this novel approach in repairing sciatic nerve damage in vivo...
May 23, 2017: Biochemical and Biophysical Research Communications
https://www.readbyqxmd.com/read/28549514/validation-of-surgical-site-infection-surveillance-data-in-colon-procedures-reported-to-the-connecticut-department-of-public-health
#13
Lauren A Backman, Evelyn Carusillo, Laurie N D'aquila, Richard Melchreit, Renee Fekieta
A validation study of 692 patients undergoing colon surgery during the fourth quarter of 2012 identified 102 surgical site infections, of which 34% were not reported to the National Healthcare Safety Network. Possible reasons for underreporting included the misinterpretation of the National Healthcare Safety Network surgical site infection definition and variations in case-finding methods. Colon procedure denominator data were also reviewed to determine inaccuracies. Error rates were highest for implant presence (34%), endoscope use (32%), and procedure duration (33%)...
June 1, 2017: American Journal of Infection Control
https://www.readbyqxmd.com/read/28549463/factors-associated-with-length-of-stay-following-trans-catheter-aortic-valve-replacement-a-multicenter-study
#14
Yaron Arbel, Nevena Zivkovic, Dhruven Mehta, Sam Radhakrishnan, Stephen E Fremes, Effat Rezaei, Asim N Cheema, Sami Al-Nasser, Ariel Finkelstein, Harindra C Wijeysundera
BACKGROUND: Most patients undergoing Transcatheter aortic valve implantation (TAVR) are elderly with significant co-morbidities and there is limited information available regarding factors that influence length of stay (LOS) post-procedure. The aim of this study was to identify the patient, and procedural factors that affect post-TAVR LOS using a contemporary multinational registry. METHODS: We conducted a retrospective cohort study, with patients recruited from three high volume tertiary institutions...
May 26, 2017: BMC Cardiovascular Disorders
https://www.readbyqxmd.com/read/28549406/supramalleolar-osteotomy-for-tibial-component-malposition-in-total-ankle-replacement
#15
Manja Deforth, Nicola Krähenbühl, Lukas Zwicky, Markus Knupp, Beat Hintermann
BACKGROUND: Persistent pain despite a total ankle replacement is not uncommon. A main source of pain may be an insufficiently balanced ankle. An alternative to the revision of the existing arthroplasty is the use of a corrective osteotomy of the distal tibia, above the stable implant. This strictly extraarticular procedure preserves the integrity of the replaced joint. The aim of this study was to review a series of patients in whom a corrective supramalleolar osteotomy was performed to realign a varus misaligned tibial component in total ankle replacement...
May 1, 2017: Foot & Ankle International
https://www.readbyqxmd.com/read/28549361/-leukocyte-esterase-as-a-diagnostic-tool-for-an-infectious-disease-of-the-knee
#16
S U Ceja-Picazo, S Fuentes-Figueroa, A H Rivera-Villa, A R Hernández-Salgado, R Torres-González, A M Pérez, J A Hernández-García, J M Pérez-Atanasio
BACKGROUND: Articular infection is an orthopedic challenge due to its difficult diagnosis and devastating results. Various diagnostic studies exist: culture, ESR, CRP, count of leukocytes, among others, but none is specific, they all take more than 30 minutes to complete, and require complex infrastructure. In this study, we determine the sensitivity and specificity of the leukocyte esterase for detection of an infectious process joint in Mexican population. MATERIAL AND METHODS: During November 2015 to April 2016, we obtained synovial fluid from two groups of patients: one with a diagnosis of synovial joint infection with or without implant, and the control group, without infection but with degenerative pathology of the knee...
November 2016: Acta Ortopédica Mexicana
https://www.readbyqxmd.com/read/28549284/long-term-results-of-the-toefit-plus-replacement-for-first-metatarsophalangeal-joint-arthritis
#17
REVIEW
Shreekant Gupta, Saqib Masud
Hallux rigidus is osteoarthritis affecting the metatarsophalangeal joint of the first toe. Patients often complain of pain and stiffness with pain being aggravated by walking, particularly during toe-off in the gait cycle. Osteoarthritis of the metatarsophalangeal joint is commonly treated with arthrodesis or resection arthroplasty. Metallic replacement of this joint is used sometimes but is not widely accepted. The use of silastic joints has problems with synovitis and implant failure. The authors used titanium implants, which can be screwed into the metatarsal and phalanx, allowing good fixation without the use of bone cement...
May 8, 2017: Foot
https://www.readbyqxmd.com/read/28549170/are-multidimensional-pain-inventory-coping-strategy-profiles-associated-with-long-term-spinal-cord-stimulation-effectiveness
#18
Mery Paroli, Olivia Bernini, Giuliano De Carolis, Lara Tollapi, Franca Bondi, Antonella Martini, Alessandro Dario, Adriana Paolicchi
Introduction.:  It is acknowledged that the way patients cope with pain may influence treatment outcome. In particular, psychological factors are deemed important when considering patients for suitability for spinal cord stimulation (SCS). Objective.:  The aim of the study is to observe how pre-implantation psychological characteristics impact the effectiveness of SCS for chronic pain. Methods.:  The analysis comprised data from 137 patients who underwent an SCS implant...
May 26, 2017: Pain Medicine: the Official Journal of the American Academy of Pain Medicine
https://www.readbyqxmd.com/read/28549125/transfemoral-transapical-and-transcatheter-aortic-valve-implantation-and-surgical-aortic-valve-replacement-a-meta-analysis-of-direct-and-adjusted-indirect-comparisons-of-early-and-mid-term-deaths
#19
Tomo Ando, Hisato Takagi, Cindy L Grines
Clinical outcomes of transfemoral-transcatheter aortic valve implantation (TF-TAVI) versus surgical aortic valve replacement (SAVR) or transapical (TA)-TAVI are limited to a few randomized clinical trials (RCTs). Because previous meta-analyses only included a limited number of adjusted studies or several non-adjusted studies, our goal was to compare and summarize the outcomes of TF-TAVI vs SAVR and TF-TAVI vs TA-TAVI exclusively with the RCT and propensity-matched cohort studies with direct and adjusted indirect comparisons to reach more precise conclusions...
May 26, 2017: Interactive Cardiovascular and Thoracic Surgery
https://www.readbyqxmd.com/read/28548943/intra-tumour-molecular-heterogeneity-of-clear-cell-renal-cell-carcinoma-reveals-the-diversity-of-the-response-to-targeted-therapies-using-patient-derived-xenograft-models
#20
Baoan Hong, Yong Yang, Sheng Guo, Shayiremu Duoerkun, Xiaohu Deng, Dawei Chen, Shijun Yu, Wubin Qian, Qixiang Li, Qing Li, Kan Gong, Ning Zhang
Inter- and intra-tumour molecular heterogeneity is increasingly recognized in clear cell renal cell carcinoma (ccRCC). It may partially explain the diversity of responses to targeted therapies and the various clinical outcomes. In this study, a 56-year-old male ccRCC patient with multiple metastases received radical nephrectomy and resection of the metastatic tumour in chest wall. The surgical specimens were implanted into nude mice to establish patient-derived xenograft (PDX) models with KI2367 model derived from the primary tumour and KI2368 model from the metastastic tumour...
May 10, 2017: Oncotarget
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