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Yu Zhu, Yingxin Gu, Shichong Qiao, Linyi Zhou, Junyu Shi, Hongchang Lai
Microorganisms are frequently introduced to dental implants during surgery and start the race for the surface with host cells before osseointegration occurs. The aim of the study was to endow implant surfaces with biological functions that reliably select cells over microbes. Nano-structured tantalum (Ta) has exhibited excellent compatibility. Thus, nano-structured Ta films were deposited on the sand-blasted, large grit and acid-etched (SLA) titanium by the magnetron sputtering method, thus forming hierarchical micro/nanostructured surfaces...
October 26, 2016: Journal of Biomedical Materials Research. Part A
Zhe Li, Jian-Guo Zhang, Yan Ye, Xiaoping Li
BACKGROUND: Accurate implantation of a depth electrode into the brain is of the greatest importance in deep brain stimulation (DBS), and various stereotactic systems have been developed for electrode implantation. However, an updated analysis of depth electrode implantation in the modern era of DBS is lacking. OBJECTIVE: This study aims at providing an updated review on targeting accuracy of DBS electrode implantation by analyzing contemporary DBS electrode implantation operations from the perspective of precision engineering...
October 27, 2016: Stereotactic and Functional Neurosurgery
Cory A Rubel, San-Pin Wu, Lin Lin, Tianyuan Wang, Rainer B Lanz, Xilong Li, Ramakrishna Kommagani, Heather L Franco, Sally A Camper, Qiang Tong, Jae-Wook Jeong, John P Lydon, Francesco J DeMayo
Altered progesterone responsiveness leads to female infertility and cancer, but underlying mechanisms remain unclear. Mice with uterine-specific ablation of GATA binding protein 2 (Gata2) are infertile, showing failures in embryo implantation, endometrial decidualization, and uninhibited estrogen signaling. Gata2 deficiency results in reduced progesterone receptor (PGR) expression and attenuated progesterone signaling, as evidenced by genome-wide expression profiling and chromatin immunoprecipitation. GATA2 not only occupies at and promotes expression of the Pgr gene but also regulates downstream progesterone responsive genes in conjunction with the PGR...
October 25, 2016: Cell Reports
Uri Landes, Alon Barsheshet, Ariel Finkelstein, Victor Guetta, Abid Assali, Amir Halkin, Hanna Vaknin-Assa, Amit Segev, Tamir Bental, Jeremy Ben-Shoshan, Israel M Barbash, Ran Kornowski
BACKGROUND: About a decade past the first transcatheter aortic valve implantation (TAVI), data are limited regarding temporal trends accompanying its evolution from novel technology to mainstream therapy. We evaluated these trends in a large multicenter TAVI registry. HYPOTHESIS: TAVI is changing and improving with time. METHODS: Patients who underwent TAVI between January 2008 and December 2014 at 3 high-volume Israeli centers were divided into 5 time quintiles according to procedure date...
October 26, 2016: Clinical Cardiology
Hirokazu Taniguchi, Shinji Takeuchi, Koji Fukuda, Takayuki Nakagawa, Sachiko Arai, Shigeki Nanjo, Tadaaki Yamada, Hiroyuki Yamaguchi, Hiroshi Mukae, Seiji Yano
Crizotinib, a first-generation anaplastic lymphoma kinase (ALK) tyrosine-kinase inhibitor, is known to be effective against echinoderm microtubule-associated protein-like 4 (EML4)-ALK-positive non-small cell lung cancers. Nonetheless, the tumors subsequently become resistant to crizotinib and recur in almost every case. The mechanism of the acquired resistance needs to be deciphered. In this study, we established crizotinib-resistant cells (A925LPE3-CR) via long-term administration of crizotinib to a mouse model of pleural carcinomatous effusions; this model involved implantation of the A925LPE3 cell line, which harbors the EML4-ALK gene rearrangement...
October 26, 2016: Cancer Science
Ugo Ripamonti, Ruqayya Parak, Roland M Klar, Caroline Dickens, Therese Dix-Peek, Raquel Duarte
OBJECTIVES: To investigate cementogenesis and alveolar bone induction during in vivo periodontal tissue regeneration upon implantation of hTGF-β3 in furcation defects of Papio ursinus and to evaluate the feasibility of gene expression studies. MATERIALS AND METHODS: Class II furcation defects (day 0) were prepared in mandibular first and second molars of three P. ursinus and on day 30 implanted with and without 75μg hTGF-β3 in Matrigel(®) matrix. On day 0, 30 and 90, cementum and alveolar bone were harvested for gene expression analyses...
October 26, 2016: Journal of Clinical Periodontology
Ana Cláudia Moreira Melo, Augusto Ricardo Andrighetto, Suélen Darab Hirt, Ana Luiza Melo Bongiolo, Siddhartha Uhrigshardt Silva, Marcos André Duarte da Silva
The aims of this study were to identify (1) patient-related factors (sex, age, craniofacial pattern and smoking habit), (2) miniscrews implants (MSI)-related factors (length and diameter) and (3) location-related factors [bone (maxilla or mandible) and area (buccal, lingual and alveolar ridge)] that may be associated with MSI loss of stability. A total of 1356 MSI were installed in 570 patients (423 females and 147 males) with mean age of 42.7 during a 10-year period and were clinically evaluated once a month until the end of the proposed movement...
October 24, 2016: Brazilian Oral Research
Marcelo Piaia, Carolina Bonet Bub, Guilherme de Menezes Succi, Margareth Torres, Thiago Henrique Costa, Fabricio Costa Pinheiro, Marcelo Henrique Napimoga
According to the Brazilian Association of Organ Transplants, in 2015, 19,408 bone transplants were performed in Brazil, over 90% by Dental Surgeons. The surgical technique itself has a respectable number of reports regarding its clinical efficacy, as measured by long-term survival of dental implants in grafted areas. Uncertainty remains, however, as to whether fresh frozen grafts from human bone donors remain immunologically innocuous in the body of the host. Six male with no previous medical history of note, including systemic diseases, surgery or blood transfusion were selected...
October 25, 2016: Cell and Tissue Banking
Pinar Cagimni, Figen Govsa, Mehmet Asim Ozer, Zuhal Kazak
OBJECTIVE: Different clinical problems may require a surgical approach to the dental arch, such as dentofacial orthopedics, implant-supported dental prothesis, maxillary orthodontics protraction, removable appliances, and posttraumatic dental reconstruction. The aim of this study is to analyze the dental arch size and type for supporting individual dental protheses. MATERIALS AND METHODS: In this study, the reference measurements on the length of the bony palate, maxillary intercanine width, maxillary intermolar width, and the ratio of the maxillary to the palatinal surface were studied in 120 bony palates using a computer software program...
October 25, 2016: Surgical and Radiologic Anatomy: SRA
Annabelle Cikankowitz, Anne Clavreul, Clément Tétaud, Laurent Lemaire, Audrey Rousseau, Nicolas Lepareur, Djamel Dabli, Francis Bouchet, Emmanuel Garcion, Philippe Menei, Olivier Couturier, François Hindré
Internal radiation strategies hold great promise for glioblastoma (GB) therapy. We previously developed a nanovectorized radiotherapy that consists of lipid nanocapsules loaded with a lipophilic complex of Rhenium-188 (LNC(188)Re-SSS). This approach resulted in an 83 % cure rate in the 9L rat glioma model, showing great promise. The efficacy of LNC(188)Re-SSS treatment was optimized through the induction of a T-cell immune response in this model, as it is highly immunogenic. However, this is not representative of the human situation where T-cell suppression is usually encountered in GB patients...
October 25, 2016: Journal of Neuro-oncology
Stefan Aufderklamm, Martin Vaegler, Alexandra Kelp, Sabine Maurer, Leon Gustafsson, Jens Mundhenk, Silke Busch, Lisa Daum, Arnulf Stenzl, Bastian Amend, Karl-Dietrich Sievert
PURPOSE: Urethral strictures are a common disease of the lower urinary tract in men. At present, the use of buccal mucosa is the method of choice for long or recurrent strictures. However, autologous tissue-engineered grafts are still under investigation for reconstructive urological surgery. The aim of this pilot study was to evaluate the use of human urothelial cells (HUC) seeded on bovine collagen type I-based cell carriers (CCC) in an animal model and to evaluate short-term outcome of the surgical procedure...
October 25, 2016: World Journal of Urology
Andreas Schuchert, Johannes Brachmann
No abstract text is available yet for this article.
October 25, 2016: Herzschrittmachertherapie & Elektrophysiologie
J Schmolders, S Koob, P Schepers, P H Pennekamp, S Gravius, D C Wirtz, R Placzek, A C Strauss
PURPOSE AND OBJECTIVE: Bone resection regarding adequate surgical margins is the treatment of choice for malignant bone tumors. In the case of metastasis-related complications, so-called skeletal-related events, it is highly important to achieve pain relief and a stable joint situation to re-mobilize the patients immediately following surgery. To bridge the often large osseous defect zones after tumor resection, both cemented and uncemented modular endoprosthetic systems are widely used...
October 25, 2016: Archives of Orthopaedic and Trauma Surgery
Nils Kristian Prenzler, Eva Bültmann, Alexandros Giourgas, Melanie Steffens, Rolf Benedikt Salcher, Stefan Stolle, Anke Lesinski-Schiedat, Thomas Lenarz, Martin Durisin
The exact pathomechanism of deafening in Meniere's disease (MD) is still unknown; intoxication of hair cells and neural damage from endolymphatic hydrops is discussed. In the literature, there are only a few reports on hearing outcome of MD patients after treatment with cochlear implantation (CI) whereby especially the comparison of MD vs. non-MD patients with CI differs. In this retrospective study, results in speech understanding [Freiburger Einsilber (FES65) and Hochmair-Schulz-Moser test in quiet (HSM) and in noise (HSM + 10 dB)] of 27 implanted MD patients were collected and compared to a matched standard CI cohort...
October 25, 2016: European Archives of Oto-rhino-laryngology
C Schulz, U M Mauer, R Mathieu
BACKGROUND: Anterior cervical corpectomy and fusion (ACCF) has become a standard procedure for patients with spondylotic myelopathy due to multisegmental stenosis of the cervical canal. In addition to the fusion technique using autogenous bone grafts and titanium implants, synthetic polyetheretherketone (PEEK) cages have been used increasingly during the last years. However, limited evidence on the clinical and radiological results of PEEK cages for ACCF exists in the literature. The study presented here is the largest series to date reporting clinical and radiological outcome as well as complication rates after one to three-level ACCF using PEEK cages augmented by an anterior plate-screw osteosynthesis...
October 25, 2016: Der Orthopäde
Harman Khatkar, Harry Hothi, Danielle de Villiers, Christian Lausmann, Daniel Kendoff, Thorsten Gehrke, John Skinner, Alister Hart
PURPOSE: Ceramic coatings have been used in metal-on-polyethylene (MOP) hips to reduce the risk of wear and also infection; the clinical efficacy of this remains unclear. This retrieval study sought to better understand the performance of coated bearing surfaces. METHODS: Forty-three coated MOP components were analysed post-retrieval for evidence of coating loss and gross polyethylene wear. Coating loss was graded using a visual semi-quantitative protocol. Evidence of gross polyethylene wear was determined by radiographic analysis and visual inspection of the retrieved implants...
October 25, 2016: International Orthopaedics
Nazife Sefi-Yurdakul, Ayse Tülin Berk
PURPOSE: To compare the visual outcomes of primary and secondary intraocular lens (IOL) implantations and to identify the risk factors for the development of strabismus in patients with pediatric cataract. METHODS: The records of the pediatric patients who had undergone cataract surgery between January 1999 and November 2014 were reviewed retrospectively. The results of the cases with cataract extraction with primary IOL implantation (primary group) and cases with secondary IOL implantation (secondary group) were compared and the risk factors for the development of strabismus were investigated...
October 25, 2016: Journal of Pediatric Ophthalmology and Strabismus
Leslie E Cohen, Thomas A Imahiyerobo, Jeffrey R Scott, Jason A Spector
BACKGROUND: The objective of this study was to evaluate the antimicrobial performance of a rifampin/minocycline-coated, non-cross-linked, acellular porcine dermal matrix (XenMatrix AB) compared to an uncoated, non-cross-linked, acellular porcine dermal matrix (Strattice) after implantation/inoculation with methicillin-resistant Staphylococcus aureus or Escherichia coli in a dorsal rabbit model. METHODS: Forty male New Zealand White rabbits were bilaterally implanted with XenMatrix AB or Strattice grafts and inoculated with clinically isolated methicillin-resistant S...
November 2016: Plastic and Reconstructive Surgery
Dennis C Hammond
No abstract text is available yet for this article.
November 2016: Plastic and Reconstructive Surgery
William P Adams, Daniel Mckee
BACKGROUND: For primary breast augmentation, several implant selection systems have been described to guide the surgeon with choosing from a variety of manufactured implant dimensions and properties. Controversy exists regarding the most efficacious method of selecting an appropriate implant size that best matches the patient's breast. METHODS: The goal of this systematic review was to provide a comprehensive list of documented implant size selection systems, and to critically evaluate them...
November 2016: Plastic and Reconstructive Surgery
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