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https://www.readbyqxmd.com/read/28938541/differential-expression-of-circulating-biomarkers-of-tumor-phenotype-and-outcomes-in-previously-treated-non-small-cell-lung-cancer-patients-receiving-erlotinib-vs-cytotoxic-chemotherapy
#1
Mary Jo Fidler, Casey Frankenberger, Richard Seto, Gabriela C Lobato, Cristina L Fhied, Selina Sayidine, Sanjib Basu, Mark Pool, Reem Karmali, Marta Batus, Wen-Rong Lie, David Hayes, Jehangir Mistry, Philip Bonomi, Jeffrey A Borgia
BACKGROUND: The objective of this study was to identify serum biomarkers capable of predicting clinical outcomes in previously-treated NSCLC patients with wild-type for EGFR activating mutations or insufficient tissue for mutation status determination. METHODS: Sixty-six Luminex immunoassays representative of biological themes that emerged from a re-analysis of transcriptome data from the Cancer Genome Atlas (TCGA) were evaluate against pretreatment serum specimens from previously-treated advanced NSCLC patients received either cytotoxic chemotherapy (n=32) or erlotinib (n=79)...
August 29, 2017: Oncotarget
https://www.readbyqxmd.com/read/28935693/a-multidimensional-blood-stimulation-assay-reveals-immune-alterations-underlying-systemic-juvenile-idiopathic-arthritis
#2
Alma-Martina Cepika, Romain Banchereau, Elodie Segura, Marina Ohouo, Brandi Cantarel, Kristina Goller, Victoria Cantrell, Emily Ruchaud, Elizabeth Gatewood, Phuong Nguyen, Jinghua Gu, Esperanza Anguiano, Sandra Zurawski, Jeanine M Baisch, Marilynn Punaro, Nicole Baldwin, Gerlinde Obermoser, Karolina Palucka, Jacques Banchereau, Sebastian Amigorena, Virginia Pascual
The etiology of sporadic human chronic inflammatory diseases remains mostly unknown. To fill this gap, we developed a strategy that simultaneously integrates blood leukocyte responses to innate stimuli at the transcriptional, cellular, and secreted protein levels. When applied to systemic juvenile idiopathic arthritis (sJIA), an autoinflammatory disease of unknown etiology, this approach identified gene sets associated with specific cytokine environments and activated leukocyte subsets. During disease remission and off treatment, sJIA patients displayed dysregulated responses to TLR4, TLR8, and TLR7 stimulation...
September 21, 2017: Journal of Experimental Medicine
https://www.readbyqxmd.com/read/28934227/hemorrhage-enhances-cytokine-complement-component-3-and-caspase-3-and-regulates-micrornas-associated-with-intestinal-damage-after-whole-body-gamma-irradiation-in-combined-injury
#3
Juliann G Kiang, Joan T Smith, Marsha N Anderson, Thomas B Elliott, Paridhi Gupta, Nagaraja S Balakathiresan, Radha K Maheshwari, Barbara Knollmann-Ritschel
Hemorrhage following whole-body γ-irradiation in a combined injury (CI) model increases mortality compared to whole-body γ-irradiation alone (RI). The decreased survival in CI is accompanied by increased bone marrow injury, decreased hematocrit, and alterations of miRNA in the kidney. In this study, our aim was to examine cytokine homeostasis, susceptibility to systemic bacterial infection, and intestinal injury. More specifically, we evaluated the interleukin-6 (IL-6)-induced stress proteins including C-reactive protein (CRP), complement 3 (C3), Flt-3 ligand, and corticosterone...
2017: PloS One
https://www.readbyqxmd.com/read/28933756/a-disposable-amperometric-sensor-based-on-high-performance-pedot-pss-ionic-liquid-nanocomposite-thin-film-modified-screen-printed-electrode-for-the-analysis-of-catechol-in-natural-water-samples
#4
Francis D Krampa, Yaw Aniweh, Gordon A Awandare, Prosper Kanyong
A conducting polymer-based composite material of poly(3,4-ethylenedioxythiophene) (PEDOT): poly(4-styrenesulfonate) (PSS) doped with different percentages of a room temperature ionic liquid (IL), 1-ethyl-3-methylimidazolium tetrafluoroborate ([EMIM][BF₄]), was prepared and a very small amount of the composite (2.0 µL) was drop-coated on the working area of a screen-printed carbon electrode (SPCE). The SPCE, modified with PEDOT:PSS/IL composite thin-film, was characterized by cyclic voltammetry (CV), electrochemical impedance spectroscopy (EIS), scanning electron microscopy (SEM), profilometry and sessile contact angle measurements...
July 26, 2017: Sensors
https://www.readbyqxmd.com/read/28930661/il-1-family-cytokines-use-distinct-molecular-mechanisms-to-signal-through-their-shared-co-receptor
#5
Sebastian Günther, Daniel Deredge, Amanda L Bowers, Alessandra Luchini, Daniel A Bonsor, Robert Beadenkopf, Lance Liotta, Patrick L Wintrode, Eric J Sundberg
Within the interleukin 1 (IL-1) cytokine family, IL-1 receptor accessory protein (IL-1RAcP) is the co-receptor for eight receptor-cytokine pairs, including those involving cytokines IL-1β and IL-33. Unlike IL-1β, IL-33 does not have a signaling complex that includes both its cognate receptor, ST2, and the shared co-receptor IL-1RAcP, which we now present here. Although the IL-1β and IL-33 complexes shared structural features and engaged identical molecular surfaces of IL-1RAcP, these cytokines had starkly different strategies for co-receptor engagement and signal activation...
September 19, 2017: Immunity
https://www.readbyqxmd.com/read/28929732/highly-durable-self-standing-solid-state-supercapacitor-based-on-an-ionic-liquid-rich-ionogel-and-porous-carbon-nanofiber-electrodes
#6
Silas K Simotwo, Parameswara Rao Chinnam, Stephanie L Wunder, Vibha Kalra
A high-performance, self-standing solid-state supercapacitor is prepared by incorporating an ionic liquid (IL)-rich ionogel made with 95 wt % IL (1-ethyl-3-methylimidazolium bis(trifluoromethylsulfonyl)imide) and 5 wt % methyl cellulose, a polymer matrix, into highly interconnected 3-D activated carbon nanofiber (CNF) electrodes. The ionogel exhibits strong mechanical properties with a storage modulus of 5 MPa and a high ionic conductivity of 5.7 mS cm(-1) at 25 °C. The high-surface-area CNF-based electrode (2282 m(2) g(-1)), obtained via an electrospinning technique, exhibits hierarchical porosity generated both in situ during pyrolysis and ex situ via KOH activation...
September 20, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28929162/interactions-and-stabilisation-of-acetone-sulfur-dioxide-and-water-with-1-octyl-3-methylimidazolium-tetrafluoroborate-omim-bf4-at-low-temperatures
#7
Matthew Buckley, Karen L Syres, Robert G Jones
The interactions between three small molecules, water (H2O), sulfur dioxide (SO2) and acetone ((CH3)2CO), with the ionic liquid (IL) 1-octyl-3-methylimidazolium tetrafluoroborate, [OMIM][BF4], have been determined using line of sight temperature programmed desorption (LOSTPD) from a gold surface. Multilayers of the IL were deposited by physical vapour deposition with multilayers of the small molecular species (adsorbed from the gas phase) at 90 K. LOSTPD was then carried out with the small molecular species desorbing first from the mixed multilayer, followed at higher temperatures by desorption of the IL from the gold surface...
September 20, 2017: Faraday Discussions
https://www.readbyqxmd.com/read/28929009/meta-analysis-of-biomarkers-for-severe-dengue-infections
#8
Kuan-Meng Soo, Bahariah Khalid, Siew-Mooi Ching, Chau Ling Tham, Rusliza Basir, Hui-Yee Chee
BACKGROUND: Dengue viral infection is an acute infection that has the potential to have severe complications as its major sequela. Currently, there is no routine laboratory biomarker with which to predict the severity of dengue infection or monitor the effectiveness of standard management. Hence, this meta-analysis compared biomarker levels between dengue fever (DF) and severe dengue infections (SDI) to identify potential biomarkers for SDI. METHODS: Data concerning levels of cytokines, chemokines, and other potential biomarkers of DF, dengue hemorrhagic fever, dengue shock syndrome, and severe dengue were obtained for patients of all ages and populations using the Scopus, PubMed, and Ovid search engines...
2017: PeerJ
https://www.readbyqxmd.com/read/28927758/evaluation-of-proinflammatory-and-immunosuppressive-cytokines-in-blood-and-bone-marrow-of-healthy-hematopoietic-stem-cell-donors
#9
Wojciech Fidyk, Iwona Mitrus, Agnieszka Ciomber, Andrzej Smagur, Agata Chwieduk, Magdalena Głowala-Kosińska, Sebastian Giebel
INTRODUCTION: Cytokine composition of bone marrow microenvironment in comparison to blood is poorly explored. The goal of this study was to investigate the levels of cytokines present in peripheral blood and bone marrow of healthy hematopoietic stem cells donors. The data obtained on this subject with addition to cytometric analysis can provide new insight into the hematopoietic stem cells microenvironment. METHODOLOGY: Study consisted of cytokine concentration analysis performed by ELISA tests of peripheral blood of healthy peripheral blood stem cells donors and bone marrow of healthy bone marrow donors...
September 15, 2017: Cytokine
https://www.readbyqxmd.com/read/28927487/ultrasonically-dispersed-ionic-liquid-based-microextraction-of-lead-in-biological-samples-of-malnourished-children-prior-to-analysis-by-flame-atomic-absorption-spectrometry
#10
Sehrish Talpur, Tasneem Gul Kazi, Hassan Imran Afridi, Farah Naz Talpur, Sooraj Nizamani, Anjum Lashari, Asma Akhtar, Mustafa Khan
In the present study, a simple ultrasonically dispersed modified liquid-phase microextraction method was developed for the extraction of lead (Pb) from blood and scalp hair samples of malnourished children (MNC). The complexation of Pb was executed by means of the complexing agent, ammonium pyrrolidinedithiocarbamate (APDC), whereas extraction was carried out through the ionic liquid (IL), 1-butyl-3-methylimidazolium hexafluorophosphate. Ultrasound energy was used for the dispersion and extraction of the metal complex into an IL because it enhances the extraction of the metal complex into infinite IL drops at a temperature range of 40–80°C for 1–5 min...
September 19, 2017: Journal of AOAC International
https://www.readbyqxmd.com/read/28927416/tumor-related-interleukins-old-validated-targets-for-new-anti-cancer-drug-development
#11
REVIEW
Sarra Setrerrahmane, Hanmei Xu
In-depth knowledge of cancer molecular and cellular mechanisms have revealed a strong regulation of cancer development and progression by the inflammation which orchestrates the tumor microenvironment. Immune cells, residents or recruited, in the inflammation milieu can have rather contrasting effects during cancer development. Accumulated clinical and experimental data support the notion that acute inflammation could exert an immunoprotective effect leading to tumor eradication. However, chronic immune response promotes tumor growth and invasion...
September 19, 2017: Molecular Cancer
https://www.readbyqxmd.com/read/28924012/inhibition-of-il-1%C3%AE-signaling-normalizes-nmda-dependent-neurotransmission-and-reduces-seizure-susceptibility-in-a-mouse-model-of-creutzfeldt-jakob-disease
#12
Ilaria Bertani, Valentina Iori, Massimo Trusel, Mattia Maroso, Claudia Foray, Susanna Mantovani, Raffaella Tonini, Annamaria Vezzani, Roberto Chiesa
Creutzfeldt-Jakob disease (CJD) is a neurodegenerative disorder caused by prion protein (PrP) misfolding, clinically recognized by cognitive and motor deficits, electroencephalographic (EEG) abnormalities and seizures. Its neurophysiological bases are not known. To assess the potential involvement of N-methyl-D-aspartate receptor (NMDAR) dysfunction, we analyzed NMDA-dependent synaptic plasticity in hippocampal slices from Tg(CJD) mice, which model a genetic form of CJD. Because PrP depletion may result in functional upregulation of NMDARs, we also analyzed PrP knockout (KO) mice...
September 18, 2017: Journal of Neuroscience: the Official Journal of the Society for Neuroscience
https://www.readbyqxmd.com/read/28922951/a-retrospective-study-of-cytokine-profiles-changes-in-mice-with-fviii-inhibitor-development-after-aav-mediated-gene-therapy-in-hemophilia-a-mouse-model
#13
Junjiang Sun, Zhenhua Yuan, Yasmina L Abajas, Dorreen E Szollosi, Genlin Hu, Baolai Hua, Xiao Xiao, Chengwen Li
The development of inhibitory autoantibodies to the infused clotting factor VIII is a major complication for severe hemophilia A management. Novel therapy options for hemophilia have significantly progressed in the last decade and a gene therapy cure for hemophilia is translating into reality. However, mechanistic studies of FVIII autoantibodies (FVIII inhibitors) have lagged behind and remain a challenge for both protein replacement and gene therapy. FVIII inhibitor formation is assumed to be a classical T cell-dependent immune response in which cytokines/chemokines play an important role...
September 19, 2017: Human Gene Therapy
https://www.readbyqxmd.com/read/28922365/isothiocyanate-enriched-moringa-seed-extract-alleviates-ulcerative-colitis-symptoms-in-mice
#14
Youjin Kim, Alex G Wu, Asha Jaja-Chimedza, Brittany L Graf, Carrie Waterman, Michael P Verzi, Ilya Raskin
Moringa (Moringa oleifera Lam.) seed extract (MSE) has anti-inflammatory and antioxidant activities. We investigated the effects of MSE enriched in moringa isothiocyanate-1 (MIC-1), its putative bioactive, on ulcerative colitis (UC) and its anti-inflammatory/antioxidant mechanism likely mediated through Nrf2-signaling pathway. Dextran sulfate sodium (DSS)-induced acute (n = 8/group; 3% DSS for 5 d) and chronic (n = 6/group; cyclic rotations of 2.5% DSS/water for 30 d) UC was induced in mice that were assigned to 4 experimental groups: healthy control (water/vehicle), disease control (DSS/vehicle), MSE treatment (DSS/MSE), or 5-aminosalicyic acid (5-ASA) treatment (positive control; DSS/5-ASA)...
2017: PloS One
https://www.readbyqxmd.com/read/28922099/the-effects-of-probiotic-supplementation-on-gene-expression-related-to-inflammation-insulin-and-lipids-in-patients-with-multiple-sclerosis-a-randomized-double-blind-placebo-controlled-trial
#15
Omid Reza Tamtaji, Ebrahim Kouchaki, Mahmoud Salami, Esmat Aghadavod, Elmira Akbari, Maryam Tajabadi-Ebrahimi, Zatollah Asemi
BACKGROUND: Limited data are available assessing the effects of probiotic supplementation on gene expression related to inflammation, insulin, and lipids in patients with multiple sclerosis (MS). OBJECTIVES: The current study was conducted to assess the effects of probiotic supplementation on gene expression related to inflammation, insulin, and lipids in patients with MS. METHODS: This randomized, double-blind, placebo-controlled clinical trial was performed among 40 patients with MS...
September 18, 2017: Journal of the American College of Nutrition
https://www.readbyqxmd.com/read/28919896/vhh-based-bispecific-antibodies-targeting-cytokine-production
#16
Maxim A Nosenko, Kamar-Sulu N Atretkhany, Vladislav V Mokhonov, Grigory A Efimov, Andrey A Kruglov, Sergei V Tillib, Marina S Drutskaya, Sergei A Nedospasov
Proinflammatory cytokines, such as TNF, IL-6, and IL-1, play pathogenic roles in multiple diseases and are attractive targets for biologic drugs. Because proinflammatory cytokines possess non-redundant protective and immunoregulatory functions, their systemic neutralization carries the potential for unwanted side effects. Therefore, next-generation anti-cytokine therapies would seek to selectively neutralize pathogenic cytokine signaling, leaving normal function intact. Fortunately, the biology of proinflammatory cytokines provides several such opportunities...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28919708/alginate-oligosaccharide-indirectly-affects-toll-like-receptor-signaling-via-the-inhibition-of-microrna-29b-in-aneurysm-patients-after-endovascular-aortic-repair
#17
Yong Yang, Zhenhuan Ma, Guokai Yang, Jia Wan, Guojian Li, Lingjuan Du, Ping Lu
Endovascular aortic repair (EVAR) is often followed by aneurysm recurrence. Alginate oligosaccharide (AOS) has potential antitumor properties as a natural product while the related mechanisms remain unclear. Toll-like receptor (TLR) signaling is associated with inflammatory activity of aneurysm and may be affected by miR-29b. Thus, inhibitory function of AOS on aneurysms was explored by measuring the important molecules in TLR4 signaling. After EVAR, a total of 248 aortic aneurysm patients were recruited and randomly assigned into two groups: AOS group (AG, oral administration 10-mg AOS daily) and control group (CG, placebo daily)...
2017: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/28918754/macrophage-activation-like-syndrome-an-immunological-entity-associated-with-rapid-progression-to-death-in-sepsis
#18
Evdoxia Kyriazopoulou, Konstantinos Leventogiannis, Anna Norrby-Teglund, Georgios Dimopoulos, Aikaterini Pantazi, Stylianos E Orfanos, Nikoletta Rovina, Iraklis Tsangaris, Theologia Gkavogianni, Elektra Botsa, Eleftheria Chassiou, Anastasia Kotanidou, Christina Kontouli, Panagiotis Chaloulis, Dimitrios Velissaris, Athina Savva, Jonas-Sundén Cullberg, Karolina Akinosoglou, Charalambos Gogos, Apostolos Armaganidis, Evangelos J Giamarellos-Bourboulis
BACKGROUND: A subanalysis of a randomized clinical trial indicated sepsis survival benefit from interleukin (IL)-1 blockade in patients with features of the macrophage activation-like syndrome (MALS). This study aimed to investigate the frequency of MALS and to develop a biomarker of diagnosis and prognosis. METHODS: Patients with infections and systemic inflammatory response syndrome were assigned to one test cohort (n = 3417) and a validation cohort (n = 1704)...
September 18, 2017: BMC Medicine
https://www.readbyqxmd.com/read/28916975/flaxseed-oil-supplementation-improve-gene-expression-levels-of-ppar-%C3%AE-lp-a-il-1-and-tnf-%C3%AE-in-type-2-diabetic-patients-with-coronary-heart-disease
#19
Ali Akbar Hashemzadeh, Nikoo Nasoohi, Fariba Raygan, Esmat Aghadavod, Elmira Akbari, Mohsen Taghizadeh, Mohammad Reza Memarzadeh, Zatollah Asemi
This study was carried out to determine the effects of flaxseed oil administration on gene expression levels related to insulin, lipid and inflammation in overweight diabetic patients with coronary heart disease (CHD). This randomized double-blind, placebo-controlled trial was conducted among 60 diabetic patients with CHD. Subjects were randomly allocated into two groups to intake either 1000 mg n-3 fatty acid from flaxseed oil containing 400 mg α-Linolenic acid [ALA (18:3n-3)] (n = 30) or placebo (n = 30) twice a day for 12 weeks...
September 15, 2017: Lipids
https://www.readbyqxmd.com/read/28913976/hplc-hrms-for-the-characterization-of-transformation-products-of-ionic-liquids
#20
Debora Fabbri, Paola Calza, Giorgio Noè, Valentina Santoro, Claudio Medana
RATIONALE: Ionic liquids (ILs) are a subject of active research in the field of alternative solvents. We studied the behaviour of a piperidine IL, 1-butyl-1-methylpiperidinium tetrafluoroborate (BMPA), through the elucidation of its transformation products (TPs) in water. METHODS: The transformation pathways of BMPA were investigated using high-performance liquid chromatography (HPLC) combined with a hybrid LTQ-Orbitrap instrument on the basis of mass defect filtering...
September 14, 2017: Rapid Communications in Mass Spectrometry: RCM
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