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Proton-pump inhibitors

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https://www.readbyqxmd.com/read/29789637/the-proton-pump-inhibitor-pantoprazole-disrupts-protein-degradation-systems-and-sensitizes-cancer-cells-to-death-under-various-stresses
#1
Yu Cao, Min Chen, Dehua Tang, Hongli Yan, Xiwei Ding, Fan Zhou, Mingming Zhang, Guifang Xu, Weijie Zhang, Shu Zhang, Yuzheng Zhuge, Lei Wang, Xiaoping Zou
Proton pump inhibitors (PPIs) play a role in antitumor activity, with studies showing specialized impacts of PPIs on cancer cell apoptosis, metastasis, and autophagy. In this study, we demonstrated that pantoprazole (PPI) increased autophagosomes formation and affected autophagic flux depending on the pH conditions. PPI specifically elevated SQSTM1 protein levels by increasing SQSTM1 transcription via NFE2L2 activation independent of the specific effect of PPI on autophagic flux. Via decreasing proteasome subunits expression, PPI significantly impaired the function of the proteasome, accompanied by the accumulation of undegraded poly-ubiquitinated proteins...
May 22, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29788903/sustained-efficacy-following-resolution-of-frequent-heartburn-with-an-over-the-counter-regimen-of-esomeprazole-20-mg-or-placebo-for-14-days-two-randomized-trials
#2
David A Peura, Anne Le Moigne, Heather Wassel, Charles Pollack
BACKGROUND: A two-week course of therapy with an over-the-counter proton-pump inhibitor (PPI) is recommended for frequent heartburn. Limited research has been conducted on the sustained efficacy of short-term PPI therapy after treatment cessation. Esomeprazole 20 mg was evaluated in the seven-day follow-up period after the two-week treatment period using pooled data from two identical randomized, double-blind, placebo-controlled studies. METHODS: Adults without confirmed diagnoses of gastroesophageal reflux disease experiencing heartburn at least two days/week in the past four weeks were eligible...
May 22, 2018: BMC Gastroenterology
https://www.readbyqxmd.com/read/29785745/use-of-proton-pump-inhibitors-is-associated-with-increased-mortality-due-to-nosocomial-pneumonia-in-bedridden-patients-receiving-tube-feeding
#3
Kosuke Hamai, Hiroshi Iwamoto, Shinichiro Ohshimo, Yu Wakabayashi, Daisuke Ihara, Kazunori Fujitaka, Hironobu Hamada, Koichi Ono, Noboru Hattori
AIM: To investigate the association between the use of proton pump inhibitors (PPI) and nosocomial pneumonia and gastrointestinal bleeding in bedridden patients receiving tube feeding. METHODS: A total of 116 bedridden hospitalized patients receiving tube feeding, of which 80 were supported by percutaneous endoscopic gastrostomy and 36 by nasogastric tube, were included in the present study. The patients were divided into two groups: 62 patients treated with PPI (PPI group) and 54 patients without PPI (non-PPI group)...
May 22, 2018: Geriatrics & Gerontology International
https://www.readbyqxmd.com/read/29781748/pediatric-sloughing-esophagitis-a-case-report-and-discussion
#4
Lulu Sun, Christina A Hickey, Brendan R Harris, Horacio M Maluf, Mai He
BACKGROUND: Sloughing esophagitis is an uncommon entity with an unclear pathogenesis characterized by desquamating sheets of squamous mucosa. It has been associated with bullous dermatologic disorders, other autoimmune diseases and has been most commonly reported in elderly, debilitated individuals on multiple medications. CASE REPORT: We report sloughing esophagitis in a previously healthy 17 year-old girl. While the initial trigger of her esophagitis is unclear, she improved with proton pump inhibitor therapy and swallowed fluticasone, with complete resolution after 6 months...
May 21, 2018: Fetal and Pediatric Pathology
https://www.readbyqxmd.com/read/29780000/the-effects-of-proton-pump-inhibitor-on-hepatic-vascular-responsiveness-and-hemodynamics-in-cirrhotic-rats
#5
I-Fang Hsin, Shao-Jung Hsu, Chiao-Lin Chuang, Teh-Ia Huo, Hui-Chun Huang, Fa-Yauh Lee, Hsin-Ling Ho, Shu-Yu Chang, Shou-Dong Lee
BACKGROUND: Liver cirrhosis is associated with increased intrahepatic resistance due to hepatic fibrosis and exaggerated vasoconstriction. Recent studies have indicated that proton pump inhibitors (PPIs), in addition to acid suppression, modulate vasoactive substances and vasoresponsiveness. PPIs are frequently prescribed in patients with cirrhosis due to a higher prevalence of peptic ulcers, however other impacts are unknown. METHODS: Liver cirrhosis was induced in Sprague-Dawley rats with common bile duct ligation (BDL)...
May 17, 2018: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/29778306/proton-pump-inhibitors-prescriptions-in-france-main-trends-from-2006-to-2016-on-french-health-insurance-database
#6
Quentin Boucherie, Franck Rouby, Diane Frankel, Patrice Roll, Joelle Micallef
Because national data on proton pump inbibitors (PPIs) consumption in France are scarce and because there is a growing literature on potential adverse drug reaction induced by this pharmacological class, we would like to more describe the main evolution of PPI use and the main characteristics of its users in France. We used a 1/97th representative sample of beneficiaries of the French health insurance called "échantillon généraliste des bénéficiaires" (EGB) to describe PPIs' use over time (duration of use by year) from 2006 to 2016...
March 7, 2018: Thérapie
https://www.readbyqxmd.com/read/29774563/alternative-therapies-for-gerd-a-way-to-personalized-antireflux-surgery
#7
Erwin Rieder, Martin Riegler, Aleksandar P Simić, Ognjan M Skrobić, Luigi Bonavina, Richard Gurski, Matthias Paireder, Donald O Castell, Sebastian F Schoppmann
Gastroesophageal reflux disease (GERD) is a common disorder, known to affect about 20% of the Western population. Although conventional medical or surgical treatment has proven effective, there is certainly room for improvements. As only 10% of GERD patients are finally treated by antireflux surgery, a large therapeutic window exists. This treatment gap consists of patients who are not effectively treated with proton pump inhibitor but do not want to run the potential risks of conventional surgery. During the last two decades, several novel and intriguing options for the surgical treatment of GERD have been introduced and found their way into clinical use...
May 17, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29774402/subtrochanteric-and-diaphyseal-femoral-fractures-in-hypophosphatasia-not-atypical-at-all
#8
F Genest, L Seefried
Risk for subtrochanteric and diaphyseal femoral fractures is considered increased in patients with hypophosphatasia (HPP). Evaluating a large cohort of HPP patients, we could for the first time quantify the prevalcence and identify both morphometric features as well as predisposing factors for this complication of severe HPP. INTRODUCTION: Subtrochanteric and diaphyseal femoral fractures have been associated with both, long-term antiresorptive treatment and metabolic bone disorders, specifically Hypophosphatasia (HPP)...
May 17, 2018: Osteoporosis International
https://www.readbyqxmd.com/read/29773689/risk-factors-for-lung-disease-progression-in-children-with-cystic-fibrosis
#9
Marieke van Horck, Kim van de Kant, Bjorn Winkens, Geertjan Wesseling, Vincent Gulmans, Han Hendriks, Chris van der Grinten, Quirijn Jӧbsis, Edward Dompeling
To identify potential risk factors for lung disease progression in children with cystic fibrosis (CF), we studied the longitudinal data of all children with CF (aged ≥5 years) registered in the Dutch CF Registry (2009-2014). Lung disease progression was expressed as a decline in lung function (FEV1 %pred) and the pulmonary exacerbation rate (PEx). Potential risk factors at baseline included: sex, age, best FEV1%pred, best forced vital capacity (FVC)%pred, genotype, BMI z-score, pancreatic insufficiency, medication use (proton pump inhibitors [PPI], prophylactic antibiotics, and inhaled corticosteroids), CF-related diabetes, allergic bronchopulmonary aspergillosis, and colonisation with Pseudomonas aeruginosa The data of 545 children were analysed...
May 17, 2018: European Respiratory Journal: Official Journal of the European Society for Clinical Respiratory Physiology
https://www.readbyqxmd.com/read/29770171/risk-of-gastric-cancer-development-after-eradication-of-helicobacter-pylori
#10
REVIEW
Ka-Shing Cheung, Wai K Leung
Helicobacter pylori ( H. pylori ) infection is the most important risk factor for gastric cancer (GC) development through the Correa's gastric carcinogenesis cascade. However, H. pylori eradication alone does not eliminate GC, as pre-neoplastic lesions (atrophic gastritis, intestinal metaplasia and dysplasia) may have already developed in some patients. It is therefore necessary to identify patients at high-risk for gastric cancer after H. pylori eradication to streamline the management plan. If the patients have not undergone endoscopy with histologic assessment, the identification of certain clinical risk factors and non-invasive testing (serum pepsinogen) can predict the risk of atrophic gastritis...
May 15, 2018: World Journal of Gastrointestinal Oncology
https://www.readbyqxmd.com/read/29767340/speculation-as-to-why-the-frequency-of-eosinophilic-esophagitis-is-increasing
#11
REVIEW
Stuart Jon Spechler
PURPOSE OF REVIEW: The frequency of eosinophilic esophagitis (EoE), an immune/antigen-mediated disorder first described in 1993, has been increasing rapidly. The purpose of this review is to consider hypotheses proposed to explain this increase and to speculate on their validity. RECENT FINDINGS: The hygiene hypothesis attributes the rise of EoE to modern hygienic conditions resulting in fewer childhood infections with microbes that might have protected against allergy development...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29767318/strategies-for-effective-discontinuation-of-proton-pump-inhibitors
#12
REVIEW
Judith Kim, John W Blackett, Daniela Jodorkovsky
PURPOSE OF REVIEW: Proton pump inhibitors (PPIs) are effective for many conditions but are often overprescribed. Recent concerns about long-term risks have made patients re-evaluate their need to take PPIs chronically, though these population-based studies have methodological weaknesses. The goal of this review is to provide evidenced-based strategies for discontinuation of PPI therapy. RECENT FINDINGS: Given that some patients experience rebound symptoms when abruptly stopping continuous PPI therapy due to its effect on hypergastrinemia, strategies focus on avoiding rebound...
May 16, 2018: Current Gastroenterology Reports
https://www.readbyqxmd.com/read/29766521/current-and-future-perspectives-in-the-management-of-gastroesophageal-reflux-disease
#13
REVIEW
Junichi Akiyama, Shiko Kuribayashi, Myong Ki Baeg, Nicola de Bortoli, Elen Valitova, Edoardo V Savarino, Motoyasu Kusano, George Triadafilopoulos
Although the prevalence of gastroesophageal reflux disease (GERD) used to be lower in East Asia as compared to Western countries, it has recently been increasing, most likely due to the socioeconomic development in the East. The prevalence of both GERD and functional gastrointestinal disorders (FGIDs) ranges between 10% and 25% worldwide and there are distinct subgroups of patients with overlapping of GERD and FGIDs. However, the true prevalence of an overlap between GERD and FGIDs can be determined only when a formal pathophysiological evaluation has been performed...
May 16, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29765253/use-of-histamine-h-2-receptor-antagonists-and-outcomes-in-patients-with-heart-failure-a-nationwide-population-based-cohort-study
#14
Kasper Adelborg, Jens Sundbøll, Morten Schmidt, Hans Erik Bøtker, Noel S Weiss, Lars Pedersen, Henrik Toft Sørensen
Background: Histamine H2 receptor activation promotes cardiac fibrosis and apoptosis in mice. However, the potential effectiveness of histamine H2 receptor antagonists (H2RAs) in humans with heart failure is largely unknown. We examined the association between H2RA initiation and all-cause mortality among patients with heart failure. Methods: Using Danish medical registries, we conducted a nationwide population-based active-comparator cohort study of new users of H2RAs and proton pump inhibitors (PPIs) after first-time hospitalization for heart failure during the period 1995-2014...
2018: Clinical Epidemiology
https://www.readbyqxmd.com/read/29762879/eosinophilic-esophagitis-latest-insights-from-diagnosis-to-therapy
#15
REVIEW
Alain Schoepfer, Carine Blanchard, Heather Dawson, Alfredo Lucendo, Aurelio Mauro, Camillo Ribi, Ekaterina Safroneeva, Edoardo V Savarino, Roberto Penagini
Eosinophilic esophagitis (EoE) represents a chronic, local immune-mediated esophageal disease, characterized clinically by symptoms related to esophageal dysfunction and histologically by eosinophil-predominant inflammation. Other systemic and local causes of esophageal eosinophilia should be excluded. Clinical manifestations or pathologic data should not be interpreted in isolation. EoE was first described as a distinct disease entity in 1993. Most patients are diagnosed with underlying food allergies. The first diagnostic and therapeutic guidelines were published in 2007 with a first update in 2011...
May 15, 2018: Annals of the New York Academy of Sciences
https://www.readbyqxmd.com/read/29761234/prevalence-and-predictors-of-small-intestinal-bacterial-overgrowth-in-irritable-bowel-syndrome-a-systematic-review-and-meta-analysis
#16
REVIEW
Binrui Chen, John Jae-Woo Kim, Yawen Zhang, Lijun Du, Ning Dai
BACKGROUND: The reported prevalence of small intestinal bacterial overgrowth (SIBO) among individuals with irritable bowel syndrome (IBS) is highly variable. The aim of the study is to estimate the prevalence and identify predictors of SIBO in IBS. METHODS: PubMed, Cochrane Library, and EMBASE through July 2017 were searched to identify studies evaluating the prevalence of SIBO in IBS. The pooled prevalence of SIBO among individuals with IBS and the pooled odds ratio (OR) of SIBO among those with IBS compared with healthy controls were calculated...
May 14, 2018: Journal of Gastroenterology
https://www.readbyqxmd.com/read/29758543/magnesium-sulfate-versus-esomeprazole-impact-on-the-neonates-of-preeclamptic-rats
#17
Amani N Shafik, Mahmoud A Khattab, Ahmed H Osman
OBJECTIVE: Preeclampsia represents a major complication of pregnancy, associated with greater maternal and fetal complications. We compared the effects of esomeprazole (a proton pump inhibitor) and magnesium sulfate (MgSO4) on the deleterious effects observed on the mother and neonates in experimentally induced preeclampsia in rats. STUDY DESIGN: Preeclampsia was induced in pregnant rats with NG-nitro-l-arginine methyl ester (L-NAME) starting from day 10-till end of pregnancy...
May 8, 2018: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/29757761/aspirin-resistance-cardiovascular-risk-game-changer
#18
Ahmed S Yassin, Hossam Abubakar, Tushar Mishra, Ahmed Subahi, Melanie Hartman, Abdelrahman Ahmed, Walid Ibrahim, Manmohan Singh, Mohit Pahuja
BACKGROUND: Aspirin (ASA) is the most used medication on the globe. ASA is a primary pillar of the secondary prevention of cardiovascular atherothromboembolic events. However, a fraction of the population does not respond to ASA as expected in a unique phenomenon called ASA resistance. Multiple mechanisms were described and studied in the literature to explain this phenomenon. AREA OF UNCERTAINTY: ASA resistance is an interesting phenomenon that is worth studying and reviewing...
May 3, 2018: American Journal of Therapeutics
https://www.readbyqxmd.com/read/29756023/endoscopic-polymer-injection-and-endoluminal-plication-in-treatment-of-gastroesophageal-reflux-disease-evaluation-of-long-term-results
#19
Eduardo Guimarães Hourneaux De Moura, Rubens A A Sallum, Ary Nasi, Martin Coronel, Diogo Turiani Hourneaux De Moura, Eduardo Turiani Hourneaux De Moura, Mauricio Kazuyoshi Minata, Marcelo Cury, Angela Falcão, Ivan Cecconello, Paulo Sakai
Background and study aims:  Us of proton pump inhibitors (PPIs) has made endoscopic treatment of gastroesophageal reflux disease (GERD) more efficient, with reduction in morbidity and complications. However, some patients persist with symptoms despite medical treatment and some are not compliant with it or cannot afford it for financial reasons, and thus they require non-pharmacological therapeutic options such as surgical fundoplication. Surgery may be effective in the short term, but there is related morbidity and concern about its long-term efficacy...
May 2018: Endoscopy International Open
https://www.readbyqxmd.com/read/29756011/transoral-incisional-fundoplication-for-reflux-after-peroral-endoscopic-myotomy-a-crucial-addition-to-our-arsenal
#20
Amy Tyberg, Anthony Choi, Monica Gaidhane, Michel Kahaleh
Introduction:  Increased esophageal acid exposure is seen in a large percentage of patients with achalasia who undergo peroral endoscopic myotomy (POEM). Endoscopic transoral fundoplication (TIF) is a novel endoscopic technique for the management of patients with chronic gastroesophageal reflux (GERD). We present the first case series evaluating the role of TIF post-POEM. Methods:  Consecutive patients 18 years or older from our academic institution who underwent a POEM procedure and subsequently underwent TIF for symptomatic reflux or regurgitation between December 2014 and June 2017 were included...
May 2018: Endoscopy International Open
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