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Lichenoid keratosis

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https://www.readbyqxmd.com/read/28443310/keratosis-lichenoides-chronica-successfully-treated-with-isotretinoin-and-methotrexate
#1
Alvin W Li, William Damsky, Brett A King
No abstract text is available yet for this article.
May 2017: JAAD Case Reports
https://www.readbyqxmd.com/read/28345255/lichenoid-folliculitis-a-unifying-concept
#2
Mamina M Turegano, Leonard C Sperling
Skin diseases presenting with keratotic papules, atrophy, cicatricial alopecia and/or "lichenoid" histopathologic changes have been described under at least 30 names. This family of diseases contains 2 subgroups, largely based on clinical features: keratosis pilaris atrophicans (KPA; including keratosis pilaris atrophicans faciei/ulerythema ophryogenes, atrophoderma vermiculata, and keratosis follicularis spinulosa decalvans); and the lichen planopilaris (LPP) subgroup (including LPP, frontal fibrosing alopecia, Graham-Little-Piccardi-Lassueur Syndrome and fibrosing alopecia in a pattern distribution)...
March 26, 2017: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/28132411/a-case-report-of-disappearing-pigmented-skin-lesions-associated-with-pembrolizumab-treatment-for-metastatic-melanoma
#3
Z J Wolner, A A Marghoob, M P Pulitzer, M A Postow, M A Marchetti
Pembrolizumab is an immune checkpoint inhibitor that targets the programmed cell death (PD)-1 receptor. Common cutaneous adverse side effects of PD-1 inhibitors include maculopapular rash, pruritus, vitiligo, and lichenoid skin and mucosal reactions. Here, we describe a man in his sixties with metastatic melanoma treated with pembrolizumab who subsequently developed fading or disappearance of pigmented skin lesions, lightening of the skin, and poliosis of the eyebrows, eyelashes, and scalp and body hair. Compared to baseline high-resolution three-dimensional total body photography, we observed fading or disappearing of solar lentigines, seborrheic keratoses, and melanocytic naevi, suggesting that PD-1 inhibitors may affect the evolution of these benign skin lesions...
January 28, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/28026045/differentiating-regressed-melanoma-from-regressed-lichenoid-keratosis
#4
Aegean H Chan, Kenneth J Shulman, Bonnie A Lee
BACKGROUND: Distinguishing regressed lichen planus-like keratosis (LPLK) from regressed melanoma can be difficult on histopathologic examination, potentially resulting in mismanagement of patients. OBJECTIVE: We aimed to identify histopathologic features by which regressed melanoma can be differentiated from regressed LPLK. METHODS: Twenty actively inflamed LPLK, 12 LPLK with regression and 15 melanomas with regression were compared and evaluated by hematoxylin and eosin staining as well as Melan-A, microphthalmia transcription factor (MiTF) and cytokeratin (AE1/AE3) immunostaining...
December 27, 2016: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/27990390/nekam-s-disease
#5
Chintaginjala Aruna, D V S B Ramamurthy, T Neelima, Haritha Bandaru
Keratosis lichenoides chronica also known as Nekam's disease is a rare mucocutaneous disorder, characterized clinically by asymptomatic violaceous keratotic papules arranged in linear, reticular, or plaque form usually on the trunk and extremities and histologically by interface dermatitis. The disease is considered rare with only 128 cases being reported in the literature till date and very few from India. We report a case of a 40-year-old man who presented with constellation of features of lichen planus, seborrheic dermatitis, and apthous ulcers, which upon workup was found to be Nekam's disease...
November 2016: Indian Dermatology Online Journal
https://www.readbyqxmd.com/read/27867740/regressing-basal-cell-carcinoma-masquerading-as-benign-lichenoid-keratosis
#6
Aleksandra Kulberg, Wolfgang Weyers
BACKGROUND: Benign lichenoid keratosis (BLK, LPLK) is often misdiagnosed clinically as superficial basal-cell carcinoma (BCC), especially when occurring on the trunk. However, BCCs undergoing regression may be associated with a lichenoid interface dermatitis that may be misinterpreted as BLK in histopathologic sections. METHODS: In order to assess the frequency of remnants of BCC in lesions interpreted as BLK, we performed step sections on 100 lesions from the trunk of male patients that had been diagnosed as BLK...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27662089/germline-nlrp1-mutations-cause-skin-inflammatory-and-cancer-susceptibility-syndromes-via-inflammasome-activation
#7
Franklin L Zhong, Ons Mamaï, Lorenzo Sborgi, Lobna Boussofara, Richard Hopkins, Kim Robinson, Ildikó Szeverényi, Takuya Takeichi, Reshmaa Balaji, Aristotle Lau, Hazel Tye, Keya Roy, Carine Bonnard, Patricia J Ahl, Leigh Ann Jones, Paul Baker, Lukas Lacina, Atsushi Otsuka, Pierre R Fournie, François Malecaze, E Birgitte Lane, Masashi Akiyama, Kenji Kabashima, John E Connolly, Seth L Masters, Vincent J Soler, Salma Samir Omar, John A McGrath, Roxana Nedelcu, Moez Gribaa, Mohamed Denguezli, Ali Saad, Sebastian Hiller, Bruno Reversade
Inflammasome complexes function as key innate immune effectors that trigger inflammation in response to pathogen- and danger-associated signals. Here, we report that germline mutations in the inflammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC). We find that NLRP1 is the most prominent inflammasome sensor in human skin, and all pathogenic NLRP1 mutations are gain-of-function alleles that predispose to inflammasome activation...
September 22, 2016: Cell
https://www.readbyqxmd.com/read/27311752/a-new-algorithm-for-the-discrimination-of-actinic-keratosis-from-normal-skin-and-squamous-cell-carcinoma-based-on-in-vivo-analysis-of-optical-properties-by-high-definition-optical-coherence-tomography
#8
M A L M Boone, M Suppa, A Marneffe, M Miyamoto, G B E Jemec, V Del Marmol
BACKGROUND: High-definition optical coherence tomography (HD-OCT) features of actinic keratosis (AK) may aid in its diagnosis and therapeutic strategy. A diagnostic algorithm permitting discrimination of AK from squamous cell carcinoma (SCC) and normal skin has been proposed. However, diagnostic accuracy strongly depends on the experience of physicians. In two recent studies, it was demonstrated that HD-OCT permits to quantify in vivo optical properties such as light attenuation in intrinsic ageing skin, in melanocytic lesions and in basal cell carcinoma...
October 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27222769/chronology-of-lichen-planus-like-keratosis-features-by-dermoscopy-a-summary-of-17-cases
#9
REVIEW
Soko Watanabe, Mizuki Sawada, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka
Dermoscopic findings for 17 cases of lichen planus-like keratosis (LPLK) were chronologically evaluated. Three males and 14 females were included in the study and the ages ranged from 43 to 85 years (median 65 years). Three cases were diagnosed based on stereotypical dermoscopic findings, while the other 14 cases were histopathologically diagnosed as LPLK. Dermoscopy photographs were divided into four groups depending on the number of days (D) from the initial visit: 1) D = 0 (initial visit or biopsy day); 2) D = 61 to 180; 3) D = 181 to 270; 4) D = 271 to 360...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27034758/various-forms-of-tobacco-usage-and-its-associated-oral-mucosal-lesions
#10
Boddu Naveen-Kumar, Ramesh Tatapudi, Reddy Sudhakara-Reddy, Satish Alapati, Kotha Pavani, Kotu-Nagavenkata Sai-Praveen
BACKGROUND: To study the various forms of tobacco usage and its associated oral mucosal lesions among the patients attending Vishnu Dental College Bhimavaram. MATERIAL AND METHODS: An observational cross-sectional study was conducted in a total of 450 patients who were divided into three groups based upon type of tobacco use, as Group-1 Reverse smoking, Group-2 Conventional smoking, Group-3 Smokeless tobacco group and each group consists of 150 subjects. RESULTS: Reverse smoking was observed to be more prevalent among old females with smoker's palate and carcinomatous lesions being the most common...
April 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/26812275/unusual-dermoscopic-patterns-of-seborrheic-keratosis
#11
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26719657/porokeratosis-presenting-with-a-benign-lichenoid-keratosis-like-appearance
#12
Min Seok Kim, Ji Min Ha, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
https://www.readbyqxmd.com/read/26686015/lichen-planus-and-other-lichenoid-dermatoses-kids-are-not-just-little-people
#13
REVIEW
Michael J Payette, Gillian Weston, Stephen Humphrey, JiaDe Yu, Kristen E Holland
Lichenoid dermatoses, a group of inflammatory skin conditions with characteristic clinical and histopathologic findings, range from common to rare. Classic lichen planus typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist. Other lichenoid dermatoses share similar clinical presentations and histopathologic findings. These include lichenoid drug eruption, lichen planus-like keratosis, lichen striatus, lichen nitidus, and keratosis lichenoides chronica...
November 2015: Clinics in Dermatology
https://www.readbyqxmd.com/read/26652284/keratosis-lichenoides-chronica-case-based-review-of-treatment-options
#14
REVIEW
Federica Pistoni, Anna Peroni, Chiara Colato, Donatella Schena, Giampiero Girolomoni
Keratosis lichenoides chronica (KLC) is a rare dermatological condition characterized by keratotic papules arranged in a parallel linear or reticular pattern and facial lesions resembling seborrheic dermatitis or rosacea. The clinical, histological and therapeutic information on 71 patients with KLC retrieved through a PubMed search plus one our new case were analyzed. KLC affects patients of all ages, with a modest male predominance. Pediatric cases represent about one quarter of patients. Diagnosis is usually delayed and histologically confirmed...
August 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/26588332/histopathologic-distinguishing-features-between-lupus-and-lichenoid-keratosis-on-the-face
#15
Amanda F Marsch, Mara Dacso, Whitney A High, Jacqueline M Junkins-Hopkins
BACKGROUND: The occurrence of lichenoid keratosis (LK) on the face is not well characterized, and the histopathologic distinction between LK and lupus erythematosus (LE) occurring on the face is often indeterminate. The authors aimed to describe differences between LE and LK occurring on the face by hematoxylin and eosin alone. METHODS: Cases of LK and LE were obtained using computer-driven queries. Clinical correlation was obtained for each lupus case. Other diagnoses were excluded for the LK cases...
December 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26352467/unique-cutaneous-reaction-to-second-and-third-generation-tyrosine-kinase-inhibitors-for-chronic-myeloid-leukemia
#16
Anisha B Patel, Alvin R Solomon, Michael J Mauro, Benjamin D Ehst
BACKGROUND: Recently developed tyrosine kinase inhibitors (TKIs) offer first-line alternatives to patients with chronic myeloid leukemia. While these medications are generally well tolerated, cutaneous reactions occur frequently and can present a management challenge. We describe a newly recognized skin reaction to dasatinib and nilotinib and extend it to the newer agent ponatinib. OBSERVATIONS: Nine patients developed varying degrees of a clinically and histopathologically lichenoid exanthem comprised of erythematous, predominately follicular papules with scale and alopecia...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26235821/generalized-keratosis-lichenoides-chronica
#17
R Santesteban-Muruzábal, M Larrea-García, I Yanguas-Bayona
No abstract text is available yet for this article.
April 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/26227743/hypertrophic-lichenoid-eruption-in-a-child-successfully-treated-using-acitretin-and-surgery-a-case-report-and-literature-review
#18
REVIEW
Songmei Geng, Yanting Liu, Hao Wang, Huling Yan, Xinwu Niu, Jennifer P Toyohara, Shengxiang Xiao
A 9-year-old boy presented with a history of keratotic violaceous plaques on the limbs and face for 8 years that had gradually progressed to erosive nodules on the extremities for 2 years. Several biopsies revealed hyperkeratosis, liquefactive degeneration of the basal layer, and a bandlike predominantly lymphocytic infiltrate. Based on the clinical and histologic findings, the patient was diagnosed with keratosis lichenoides chronica, a rare chronic dermatosis that is particularly uncommon in childhood. There are fewer than 20 reported cases of pediatric-onset keratosis lichenoides chronica in the current literature, with occurrence of pseudoepitheliomatous hyperplasia of primary keratosis lichenoides chronica lesions being even rarer...
November 2015: Pediatric Dermatology
https://www.readbyqxmd.com/read/25359646/a-topical-imiquimod-induced-oral-mucosal-lichenoid-reaction-a-case-report
#19
Ronald S Brown, Andre A Farquharson
BACKGROUND: Imiquimod (IMI) is a topical immune response modifier used in the treatment of actinic keratosis and cheilitis. Actinic cheilitis is a potentially premalignant condition that requires therapeutic intervention. IMI therapy is noted for producing cutaneous and mucosal adverse effects. The authors report the case of an 88-year-old woman who was treated for actinic cheilitis of the upper lip with IMI and who consequently experienced an oral mucosal lichenoid reaction of the lower lip and right buccal mucosa...
November 2014: Journal of the American Dental Association
https://www.readbyqxmd.com/read/24813845/vanishing-seborrhoeic-keratosis
#20
LETTER
Emilio Sudy, Francisco Urbina, Carlos Misad
No abstract text is available yet for this article.
2014: Acta Dermatovenerologica Croatica: ADC
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