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Lichenoid keratosis

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https://www.readbyqxmd.com/read/27867740/regressing-basal-cell-carcinoma-masquerading-as-benign-lichenoid-keratosis
#1
Aleksandra Kulberg, Wolfgang Weyers
BACKGROUND: Benign lichenoid keratosis (BLK, LPLK) is often misdiagnosed clinically as superficial basal-cell carcinoma (BCC), especially when occurring on the trunk. However, BCCs undergoing regression may be associated with a lichenoid interface dermatitis that may be misinterpreted as BLK in histopathologic sections. METHODS: In order to assess the frequency of remnants of BCC in lesions interpreted as BLK, we performed step sections on 100 lesions from the trunk of male patients that had been diagnosed as BLK...
October 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27662089/germline-nlrp1-mutations-cause-skin-inflammatory-and-cancer-susceptibility-syndromes-via-inflammasome-activation
#2
Franklin L Zhong, Ons Mamaï, Lorenzo Sborgi, Lobna Boussofara, Richard Hopkins, Kim Robinson, Ildikó Szeverényi, Takuya Takeichi, Reshmaa Balaji, Aristotle Lau, Hazel Tye, Keya Roy, Carine Bonnard, Patricia J Ahl, Leigh Ann Jones, Paul Baker, Lukas Lacina, Atsushi Otsuka, Pierre R Fournie, François Malecaze, E Birgitte Lane, Masashi Akiyama, Kenji Kabashima, John E Connolly, Seth L Masters, Vincent J Soler, Salma Samir Omar, John A McGrath, Roxana Nedelcu, Moez Gribaa, Mohamed Denguezli, Ali Saad, Sebastian Hiller, Bruno Reversade
Inflammasome complexes function as key innate immune effectors that trigger inflammation in response to pathogen- and danger-associated signals. Here, we report that germline mutations in the inflammasome sensor NLRP1 cause two overlapping skin disorders: multiple self-healing palmoplantar carcinoma (MSPC) and familial keratosis lichenoides chronica (FKLC). We find that NLRP1 is the most prominent inflammasome sensor in human skin, and all pathogenic NLRP1 mutations are gain-of-function alleles that predispose to inflammasome activation...
September 22, 2016: Cell
https://www.readbyqxmd.com/read/27311752/a-new-algorithm-for-the-discrimination-of-actinic-keratosis-from-normal-skin-and-squamous-cell-carcinoma-based-on-in-vivo-analysis-of-optical-properties-by-high-definition-optical-coherence-tomography
#3
M A L M Boone, M Suppa, A Marneffe, M Miyamoto, G B E Jemec, V Del Marmol
BACKGROUND: High-definition optical coherence tomography (HD-OCT) features of actinic keratosis (AK) may aid in its diagnosis and therapeutic strategy. A diagnostic algorithm permitting discrimination of AK from squamous cell carcinoma (SCC) and normal skin has been proposed. However, diagnostic accuracy strongly depends on the experience of physicians. In two recent studies, it was demonstrated that HD-OCT permits to quantify in vivo optical properties such as light attenuation in intrinsic ageing skin, in melanocytic lesions and in basal cell carcinoma...
October 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27222769/chronology-of-lichen-planus-like-keratosis-features-by-dermoscopy-a-summary-of-17-cases
#4
REVIEW
Soko Watanabe, Mizuki Sawada, Itaru Dekio, Sumiko Ishizaki, Mariko Fujibayashi, Masaru Tanaka
Dermoscopic findings for 17 cases of lichen planus-like keratosis (LPLK) were chronologically evaluated. Three males and 14 females were included in the study and the ages ranged from 43 to 85 years (median 65 years). Three cases were diagnosed based on stereotypical dermoscopic findings, while the other 14 cases were histopathologically diagnosed as LPLK. Dermoscopy photographs were divided into four groups depending on the number of days (D) from the initial visit: 1) D = 0 (initial visit or biopsy day); 2) D = 61 to 180; 3) D = 181 to 270; 4) D = 271 to 360...
April 2016: Dermatology Practical & Conceptual
https://www.readbyqxmd.com/read/27034758/various-forms-of-tobacco-usage-and-its-associated-oral-mucosal-lesions
#5
Boddu Naveen-Kumar, Ramesh Tatapudi, Reddy Sudhakara-Reddy, Satish Alapati, Kotha Pavani, Kotu-Nagavenkata Sai-Praveen
BACKGROUND: To study the various forms of tobacco usage and its associated oral mucosal lesions among the patients attending Vishnu Dental College Bhimavaram. MATERIAL AND METHODS: An observational cross-sectional study was conducted in a total of 450 patients who were divided into three groups based upon type of tobacco use, as Group-1 Reverse smoking, Group-2 Conventional smoking, Group-3 Smokeless tobacco group and each group consists of 150 subjects. RESULTS: Reverse smoking was observed to be more prevalent among old females with smoker's palate and carcinomatous lesions being the most common...
April 2016: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/26812275/unusual-dermoscopic-patterns-of-seborrheic-keratosis
#6
Lorenzo Squillace, Milena Cappello, Caterina Longo, Elvira Moscarella, Roberto Alfano, Giuseppe Argenziano
BACKGROUND: Seborrheic keratoses (SKs) may sometimes mimic benign and malignant skin tumors, and a biopsy can be necessary in order to rule out malignancy. METHODS: From the database of our pigmented lesion clinic, we evaluated the dermoscopic features of difficult-to-diagnose SKs that were biopsied between January 2010 and December 2014. RESULTS: SKs represented 3.8% of all excised lesions (161/ 4,182). Specifically, 91 (56.5%) were excised to rule out melanoma, 63 (39...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26719657/porokeratosis-presenting-with-a-benign-lichenoid-keratosis-like-appearance
#7
Min Seok Kim, Ji Min Ha, Eun Byul Cho, Eun Joo Park, Kwang Ho Kim, Kwang Joong Kim
No abstract text is available yet for this article.
December 2015: Annals of Dermatology
https://www.readbyqxmd.com/read/26686015/lichen-planus-and-other-lichenoid-dermatoses-kids-are-not-just-little-people
#8
REVIEW
Michael J Payette, Gillian Weston, Stephen Humphrey, JiaDe Yu, Kristen E Holland
Lichenoid dermatoses, a group of inflammatory skin conditions with characteristic clinical and histopathologic findings, range from common to rare. Classic lichen planus typically presents as pruritic, polygonal, violaceous flat-topped papules and plaques; many variants in morphology and location also exist. Other lichenoid dermatoses share similar clinical presentations and histopathologic findings. These include lichenoid drug eruption, lichen planus-like keratosis, lichen striatus, lichen nitidus, and keratosis lichenoides chronica...
November 2015: Clinics in Dermatology
https://www.readbyqxmd.com/read/26652284/keratosis-lichenoides-chronica-case-based-review-of-treatment-options
#9
Federica Pistoni, Anna Peroni, Chiara Colato, Donatella Schena, Giampiero Girolomoni
Keratosis lichenoides chronica (KLC) is a rare dermatological condition characterized by keratotic papules arranged in a parallel linear or reticular pattern and facial lesions resembling seborrheic dermatitis or rosacea. The clinical, histological and therapeutic information on 71 patients with KLC retrieved through a PubMed search plus one our new case were analyzed. KLC affects patients of all ages, with a modest male predominance. Pediatric cases represent about one quarter of patients. Diagnosis is usually delayed and histologically confirmed...
August 2016: Journal of Dermatological Treatment
https://www.readbyqxmd.com/read/26588332/histopathologic-distinguishing-features-between-lupus-and-lichenoid-keratosis-on-the-face
#10
Amanda F Marsch, Mara Dacso, Whitney A High, Jacqueline M Junkins-Hopkins
BACKGROUND: The occurrence of lichenoid keratosis (LK) on the face is not well characterized, and the histopathologic distinction between LK and lupus erythematosus (LE) occurring on the face is often indeterminate. The authors aimed to describe differences between LE and LK occurring on the face by hematoxylin and eosin alone. METHODS: Cases of LK and LE were obtained using computer-driven queries. Clinical correlation was obtained for each lupus case. Other diagnoses were excluded for the LK cases...
December 2015: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/26352467/unique-cutaneous-reaction-to-second-and-third-generation-tyrosine-kinase-inhibitors-for-chronic-myeloid-leukemia
#11
Anisha B Patel, Alvin R Solomon, Michael J Mauro, Benjamin D Ehst
BACKGROUND: Recently developed tyrosine kinase inhibitors (TKIs) offer first-line alternatives to patients with chronic myeloid leukemia. While these medications are generally well tolerated, cutaneous reactions occur frequently and can present a management challenge. We describe a newly recognized skin reaction to dasatinib and nilotinib and extend it to the newer agent ponatinib. OBSERVATIONS: Nine patients developed varying degrees of a clinically and histopathologically lichenoid exanthem comprised of erythematous, predominately follicular papules with scale and alopecia...
2016: Dermatology: International Journal for Clinical and Investigative Dermatology
https://www.readbyqxmd.com/read/26235821/generalized-keratosis-lichenoides-chronica
#12
R Santesteban-Muruzábal, M Larrea-García, I Yanguas-Bayona
No abstract text is available yet for this article.
April 2016: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/26227743/hypertrophic-lichenoid-eruption-in-a-child-successfully-treated-using-acitretin-and-surgery-a-case-report-and-literature-review
#13
REVIEW
Songmei Geng, Yanting Liu, Hao Wang, Huling Yan, Xinwu Niu, Jennifer P Toyohara, Shengxiang Xiao
A 9-year-old boy presented with a history of keratotic violaceous plaques on the limbs and face for 8 years that had gradually progressed to erosive nodules on the extremities for 2 years. Several biopsies revealed hyperkeratosis, liquefactive degeneration of the basal layer, and a bandlike predominantly lymphocytic infiltrate. Based on the clinical and histologic findings, the patient was diagnosed with keratosis lichenoides chronica, a rare chronic dermatosis that is particularly uncommon in childhood. There are fewer than 20 reported cases of pediatric-onset keratosis lichenoides chronica in the current literature, with occurrence of pseudoepitheliomatous hyperplasia of primary keratosis lichenoides chronica lesions being even rarer...
November 2015: Pediatric Dermatology
https://www.readbyqxmd.com/read/25359646/a-topical-imiquimod-induced-oral-mucosal-lichenoid-reaction-a-case-report
#14
Ronald S Brown, Andre A Farquharson
BACKGROUND: Imiquimod (IMI) is a topical immune response modifier used in the treatment of actinic keratosis and cheilitis. Actinic cheilitis is a potentially premalignant condition that requires therapeutic intervention. IMI therapy is noted for producing cutaneous and mucosal adverse effects. The authors report the case of an 88-year-old woman who was treated for actinic cheilitis of the upper lip with IMI and who consequently experienced an oral mucosal lichenoid reaction of the lower lip and right buccal mucosa...
November 2014: Journal of the American Dental Association
https://www.readbyqxmd.com/read/24813845/vanishing-seborrhoeic-keratosis
#15
LETTER
Emilio Sudy, Francisco Urbina, Carlos Misad
No abstract text is available yet for this article.
2014: Acta Dermatovenerologica Croatica: ADC
https://www.readbyqxmd.com/read/24568491/prevalence-of-potentially-malignant-oral-mucosal-lesions-among-tobacco-users-in-jeddah-saudi-arabia
#16
Safia Ali Al-Attas, Suzan Seif Ibrahim, Hala Abbas Amer, Zeinab El-Said Darwish, Mona Hassan Hassan
Smoking is recognized as a health problem worldwide and there is an established tobacco epidemic in Saudi Arabia as in many other countries, with tobacco users at increased risk of developing many diseases. This cross sectional study was conducted to assess the prevalence of oral mucosal, potentially malignant or malignant, lesions associated with tobacco use among a stratified cluster sample of adults in Jeddah, Saudi Arabia. A sample size of 599 was collected and each participant underwent clinical conventional oral examination and filled a questionnaire providing information on demographics, tobacco use and other relevant habits...
2014: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/24442058/chronic-keratosis-lichenoides-rare-and-elusive
#17
LETTER
M Ljubenovic, D Ljubenovic, D Mihailovic, V Lazarevic, I Binic
No abstract text is available yet for this article.
December 2013: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/24117926/dermal-changes-in-superficial-basal-cell-carcinoma-melanoma-in-situ-and-actinic-keratosis-and-their-implications
#18
RANDOMIZED CONTROLLED TRIAL
Viktoryia Kazlouskaya, Saurabh Malhotra, Raquel Navarro, Karen Nguyen Wu, Marianna Shvartsbeyn, Chen Shengli, Jiang Gui, Dirk M Elston
BACKGROUND: Basal cell carcinoma (BCC) has a characteristic stroma, but less is known about the dermal characteristics associated with melanoma in situ (MIS) and actinic keratosis (AK). MATERIALS AND METHODS: Dermal changes were studied in 301 specimens of AK, BCC and MIS. Subsequently, blinded images of dermal changes from 90 randomly selected cases of those entities were used to assess the predictive value of the dermal changes. Agreement with the final diagnosis was calculated using kappa coefficient (κ)...
December 2013: Journal of Cutaneous Pathology
https://www.readbyqxmd.com/read/23860115/clinical-and-histopathologic-study-of-benign-lichenoid-keratosis-on-the-face
#19
Han Su Kim, Eun Joo Park, In Ho Kwon, Kwang Ho Kim, Kwang Joong Kim
Benign lichenoid keratosis is a cutaneous entity that consists of a nonpruritic papule or slightly indurated plaque that is histologically characterized by a band-like inflammatory infiltrate with interface involvement. The purpose of this study was to investigate the clinical and histopathologic features of benign lichenoid keratosis localized on the face. Fourteen benign lichenoid keratosis patients diagnosed clinically and histopathologically in our clinic during the 10-year period from 2002 to 2012 were studied...
October 2013: American Journal of Dermatopathology
https://www.readbyqxmd.com/read/23785648/lichenoid-keratosis-non-invasive-imaging-in-the-setting-of-diagnostic-uncertainty
#20
Marigdalia K Ramirez-Fort, Samer Al Jalbout, Harald Kittler, Giovanni Pellacani
No abstract text is available yet for this article.
April 2013: Dermatology Practical & Conceptual
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