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JOURNAL ARTICLE
Maria B Sarratea, Andrés Sánchez Alberti, Daniela M Redolfi, Sofía Noli Truant, Laura V Iannantuono Lopez, Augusto E Bivona, Roy A Mariuzza, Marisa M Fernández, Emilio L Malchiodi
BACKGROUND: During viral infections, nucleic acid sensing by intracellular receptors can trigger type I interferon (IFN-I) production, key mediators in antiviral innate immunity. However, many flaviviruses use non-structural proteins to evade immune sensing favoring their survival. These mechanisms remain poorly characterized. Here, we studied the role of Zika virus (ZIKV) NS4B protein in the inhibition of IFN-I induction pathway and its biophysical interaction with host proteins. METHODS: Using different cell-based assays, we studied the effect of ZIKV NS4B in the activation of interferon regulatory factors (IRFs), NF-κB, cytokines secretion and the expression of interferon-stimulating genes (ISG)...
October 4, 2023: Biochimica et Biophysica Acta. General Subjects
#22
REVIEW
Recurrence in cholesteatoma surgery: what have we learnt and where are we going? A narrative review.
Chiara Bovi, Alberto Luchena, Rachele Bivona, Daniele Borsetto, Nathan Creber, Giovanni Danesi
No abstract text is available yet for this article.
April 2023: Acta Otorhinolaryngologica Italica
#23
JOURNAL ARTICLE
Frances L Morales, Derek J Bivona, Mohamad Abdi, Rohit Malhotra, Oliver Monfredi, Andrew Darby, Pamela K Mason, J Michael Mangrum, Sula Mazimba, Robert W Stadler, Frederick H Epstein, Kenneth C Bilchick, Pim J A Oomen
The aim was to test the hypothesis that left ventricular (LV) and right ventricular (RV) activation from body surface electrical mapping (CardioInsight 252-electrode vest, Medtronic) identifies optimal cardiac resynchronization therapy (CRT) pacing strategies and outcomes in 30 patients. The LV80, RV80, and BIV80 were defined as the times to 80% LV, RV, or biventricular electrical activation. Smaller differences in the LV80 and RV80 (|LV80-RV80|) with synchronized LV pacing predicted better LV function post-CRT (p = 0...
September 6, 2023: Journal of Cardiovascular Translational Research
#24
JOURNAL ARTICLE
Carmelo Bonomo, Paolo Giuseppe Bonacci, Dalida Angela Bivona, Alessia Mirabile, Dafne Bongiorno, Emanuele Nicitra, Andrea Marino, Carmela Bonaccorso, Giuseppe Consiglio, Cosimo Gianluca Fortuna, Stefania Stefani, Nicolò Musso
The discovery of compounds with antibacterial activity is crucial in the ongoing battle against antibiotic resistance. We developed two QSAR models to design six novel heteroaryl drug candidates and assessed their antibacterial properties against nine ATCC strains, including Enterococcus faecalis , Staphylococcus aureus , Klebsiella pneumoniae , Acinetobacter baumannii , Pseudomonas aeruginosa , and also Salmonella enterica and Escherichia coli , many of which belong to the ESKAPE group. We combined PB4, a previously tested compound from published studies, with GC-VI-70, a newly discovered compound, with the best cytotoxicity/MIC profile...
August 10, 2023: Antibiotics
#25
Yask Gupta, David J Friedman, Michelle McNulty, Atlas Khan, Brandon Lane, Chen Wang, Juntao Ke, Gina Jin, Benjamin Wooden, Andrea L Knob, Tze Y Lim, Gerald B Appel, Kinsie Huggins, Lili Liu, Adele Mitrotti, Megan C Stangl, Andrew Bomback, Rik Westland, Monica Bodria, Maddalena Marasa, Ning Shang, David J Cohen, Russell J Crew, William Morello, Pietro Canetta, Jai Radhakrishnan, Jeremiah Martino, Qingxue Liu, Wendy K Chung, Angelica Espinoza, Yuan Luo, Wei-Qi Wei, Qiping Feng, Chunhua Weng, Yilu Fang, Iftikhar J Kullo, Mohammadreza Naderian, Nita Limdi, Marguerite R Irvin, Hemant Tiwari, Sumit Mohan, Maya Rao, Geoffrey Dube, Ninad S Chaudhary, Orlando M Gutiérrez, Suzanne E Judd, Mary Cushman, Leslie A Lange, Ethan M Lange, Daniel L Bivona, Miguel Verbitsky, Cheryl A Winkler, Jeffrey B Kopp, Dominick Santoriello, Ibrahim Batal, Sérgio Veloso Brant Pinheiro, Eduardo Araújo Oliveira, Ana Cristina Simoes E Silva, Isabella Pisani, Enrico Fiaccadori, Fangming Lin, Loreto Gesualdo, Antonio Amoroso, Gian Marco Ghiggeri, Vivette D D'Agati, Riccardo Magistroni, Eimear E Kenny, Ruth J F Loos, Giovanni Montini, Friedhelm Hildebrandt, Dirk S Paul, Slavé Petrovski, David B Goldstein, Matthias Kretzler, Rasheed Gbadegesin, Ali G Gharavi, Krzysztof Kiryluk, Matthew G Sampson, Martin R Pollak, Simone Sanna-Cherchi
Black Americans have a significantly higher risk of developing chronic kidney disease (CKD), especially focal segmental glomerulosclerosis (FSGS), than European Americans. Two coding variants (G1 and G2) in the APOL1 gene play a major role in this disparity. While 13% of Black Americans carry the high-risk recessive genotypes, only a fraction of these individuals develops FSGS or kidney failure, indicating the involvement of additional disease modifiers. Here, we show that the presence of the APOL1 p.N264K missense variant, when co-inherited with the G2 APOL1 risk allele, substantially reduces the penetrance of the G1G2 and G2G2 high-risk genotypes by rendering these genotypes low-risk...
August 4, 2023: medRxiv
#26
JOURNAL ARTICLE
Claudia Sacchetti, Bernard Landau, Sérgio P Ávila
In this work, all the Lower Pliocene gastropod assemblages of Santa Maria Island are revised. These all form part of the Touril Complex. Seventy-seven species are identified representing 61 genera. Two species are described as new: Bittium miradouroense nov. sp. and Erato mayeri nov. sp. The name Tritonium secans Bronn in Reiss 1862 is considered a junior subjective synonym of Monoplex comptus (A. Adams, 1855). Pleurotoma perturrita Bronn in Reiss 1862 is considered a junior subjective synonym of Crassopleura maravignae (Bivona, 1838)...
May 24, 2023: Zootaxa
#27
JOURNAL ARTICLE
Alfio Spina, Paolo Guarnaccia, Michele Canale, Rosalia Sanfilippo, Michele Bizzini, Sebastiano Blangiforti, Silvia Zingale, Angela Roberta Lo Piero, Maria Allegra, Angelo Sicilia, Carmelo Nicotra, Umberto Anastasi
In recent years, the growth of tetraploid Sicilian wheat landraces has been arousing increasing interest. In this study, eighteen local genotypes of Triticum turgidum subsp. turgidum , belonging to the groups 'Bufala', 'Ciciredda', 'Bivona' and 'Paola', and two cultivars of Triticum turgidum subsp. durum (the old variety 'Bidì', and a more recent variety 'Simeto') were assessed for the characteristics of the grain and bread-making performance of their flours and doughs, as well as the quality of the loaves...
July 14, 2023: Plants (Basel, Switzerland)
#28
JOURNAL ARTICLE
Salvatore Brullo, Cristian Brullo, Salvatore Cambria, Valeria Tomaselli, Alessandro Crisafulli, Giuseppe Siracusa, Pietro Minissale, Gianpietro Giusso Del Galdo
The populations usually attributed to Solenopsisbivonae (Tineo) M.B.Crespo, Serra & A.Juan are investigated from a taxonomical and morphological viewpoint. Within this species complex, four new subspecies occurring in Sicily and Calabria are recognized, such as subsp. bivonae, subsp. madoniarum, subsp. peloritana and subsp. brutia. In addition, a new species from Cyprus described as S.meikleana and S.bacchettae from Sardinia must be included in this group. The synonymy, typification, description, seed testa morphology, chorology, ecology, illustrations, conservation status, and examined specimens for each taxon are provided...
2023: PhytoKeys
#29
Asmin Tulpule, Shruti Menon, Marcus Breese, Yone Lin, Hannah Allegakoen, Shruthi Perati, Ann Heslin, Max Horlbeck, Jonathan Weissman, Alejandro Sweet-Cordero, Trever Bivona
The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader question of whether and how oncogenes create tumor-specific vulnerabilities within DDR networks remains unanswered. Native FET protein family members are among the earliest proteins recruited to DNA double-strand breaks (DSBs) during the DDR, though the function of both native FET proteins and FET fusion oncoproteins in DSB repair remains poorly defined...
May 29, 2023: Research Square
#30
REVIEW
Jovanka Gencel-Augusto, Wei Wu, Trever G Bivona
Long non-coding RNAs (LncRNAs) are mRNA-like molecules that do not encode for proteins and that are longer than 200 nucleotides. LncRNAs play important biological roles in normal cell physiology and organism development. Therefore, deregulation of their activities is involved in disease processes such as cancer. Lung cancer is the leading cause of cancer-related deaths due to late stage at diagnosis, distant metastasis, and high rates of therapeutic failure. LncRNAs are emerging as important molecules in lung cancer for their oncogenic or tumor-suppressive functions...
June 10, 2023: Cancers
#31
Ismail M Meraz, Mourad Majidi, Bingliang Fang, Feng Meng, Lihui Gao, RuPing Shao, Renduo Song, Feng Li, Yonathan Lissanu, Huiqin Chen, Min Jin Ha, Qi Wang, Jing Wang, Elizabeth Shpall, Sung Yun Jung, Franziska Haderk, Philippe Gui, Jonathan Wesley Riess, Victor Olivas, Trever G Bivona, Jack A Roth
No abstract text is available yet for this article.
June 6, 2023: Communications Biology
#32
Shruti Menon, Marcus R Breese, Yone Phar Lin, Hannah Allegakoen, Shruthi Perati, Ann Heslin, Max A Horlbeck, Jonathan Weissman, E Alejandro Sweet-Cordero, Trever G Bivona, Asmin Tulpule
The genetic principle of synthetic lethality is clinically validated in cancers with loss of specific DNA damage response (DDR) pathway genes (i.e. BRCA1/2 tumor suppressor mutations). The broader question of whether and how oncogenes create tumor-specific deficiencies within DDR networks remains to be defined. Native FET protein family members are among the earliest proteins recruited to DNA double-strand breaks (DSBs) during the DDR, though the function of both native FET proteins and FET fusion oncoproteins in DSB repair remains poorly defined...
May 1, 2023: bioRxiv
#33
REVIEW
Giulia Bivona, Matilda Iemmolo, Giulio Ghersi
Alzheimer's disease (AD) is a scourge for patients, caregivers and healthcare professionals due to the progressive character of the disease and the lack of effective treatments. AD is considered a proteinopathy, which means that aetiological and clinical features of AD have been linked to the deposition of amyloid β (Aβ) and hyperphosphorylated tau protein aggregates throughout the brain, with Aβ and hyperphosphorylated tau representing classical AD hallmarks. However, some other putative mechanisms underlying the pathogenesis of the disease have been proposed, including inflammation in the brain, microglia activation, impaired hippocampus neurogenesis and alterations in the production and release of neurotrophic factors...
May 4, 2023: International Journal of Molecular Sciences
#34
REVIEW
Matilda Iemmolo, Giulio Ghersi, Giulia Bivona
Neuroinflammation plays a fundamental role in the development and progression of neurodegenerative diseases. It could therefore be said that neuroinflammation in neurodegenerative pathologies is not a consequence but a cause of them and could represent a therapeutic target of neuronal degeneration. CX3CL1 and several proteases (ADAMs/MMPs) are strongly involved in the inflammatory pathways of these neurodegenerative pathologies with multiple effects. On the one hand, ADAMs have neuroprotective and anti-apoptotic effects; on the other hand, they target cytokines and chemokines, thus causing inflammatory processes and, consequently, neurodegeneration...
April 28, 2023: International Journal of Molecular Sciences
#35
JOURNAL ARTICLE
Ismail M Meraz, Mourad Majidi, Bingliang Fang, Feng Meng, Lihui Gao, RuPing Shao, Renduo Song, Feng Li, Yonathan Lissanu, Huiqin Chen, Min Jin Ha, Qi Wang, Jing Wang, Elizabeth Shpall, Sung Yun Jung, Franziska Haderk, Philippe Gui, Jonathan Wesley Riess, Victor Olivas, Trever G Bivona, Jack A Roth
Osimertinib sensitive and resistant NSCLC NCI-H1975 clones are used to model osimertinib acquired resistance in humanized and non-humanized mice and delineate potential resistance mechanisms. No new EGFR mutations or loss of the EGFR T790M mutation are found in resistant clones. Resistant tumors grown under continuous osimertinib pressure both in humanized and non-humanized mice show aggressive tumor regrowth which is significantly less sensitive to osimertinib as compared with parental tumors. 3-phosphoinositide-dependent kinase 1 (PDK1) is identified as a potential driver of osimertinib acquired resistance, and its selective inhibition by BX795 and CRISPR gene knock out, sensitizes resistant clones...
May 11, 2023: Communications Biology
#36
JOURNAL ARTICLE
Hanen Enneb, Khaled Athmouni, Rahma Thabet, Habib Ayadi
In this research paper, we investigated the effect of Euphorbia bivonae extract compounds on the lethality of brine shrimp Artemia salina and on the embryonic cell line (HEK293) proliferation. Our GC/MS analysis revealed that the E. bivonae ethanolic extract contained essentially sitsoterol, euphol and lupeol. The 24-h LC50 was determined using the probit analysis method (LC50= 357.11mg l-1). Depending on this cytotoxicity test result, E. bivona extract induced a significant increase of Superoxide Dismutase (SOD), Catalase (CAT), Glutathione-Peroxidase (GPx) activities, and lipid peroxidation (LPO) in A...
April 7, 2023: Chemistry & Biodiversity
#37
Nicholas Borja, Paulo Borjas-Mendoza, Stephanie Bivona, LéShon Peart, Joanna Gonzalez, Brittney Keira Johnson, Shengru Guo, Roman Yusupov, Guney Bademci, Mustafa Tekin
Recurrent de novo missense variants in H4 histone genes have recently been associated with a novel neurodevelopmental syndrome that is characterized by intellectual disability and developmental delay as well as more variable findings that include short stature, microcephaly, and facial dysmorphisms. A 4-year-old male with autism, developmental delay, microcephaly, and a happy demeanor underwent evaluation through the Undiagnosed Disease Network. He was clinically suspected to have Angelman syndrome; however, molecular testing was negative...
March 29, 2023: American Journal of Medical Genetics. Part A
#38
JOURNAL ARTICLE
Orlando G Elso, Natacha Cerny, Laura C Laurella, Augusto E Bivona, Andrés Sánchez Alberti, Celina Morales, Cesar A N Catalán, Emilio L Malchiodi, Valeria P Sülsen
Chagas disease is an infection caused by the protozoan Trypanosoma cruzi, affecting 6-8 million people worldwide. Only two drugs are available for its treatment, having a limited efficacy and adverse side-effects. Estafietin is a sesquiterpene lactone isolated from Stevia alpina with in vitro activity against T. cruzi and low cytotoxicity against mammalian cells. The aim of this work was to predict the toxicologic profile of estafietin by in silico methods and assess its in vivo activity on a murine model of Chagas disease...
March 20, 2023: Natural Product Research
#39
JOURNAL ARTICLE
Jimena Borgo, Orlando G Elso, Jessica Gomez, Mauro Coll, Cesar A N Catalán, Juan Mucci, Guzmán Alvarez, Lía M Randall, Patricia Barrera, Emilio L Malchiodi, Augusto E Bivona, María Florencia Martini, Valeria P Sülsen
Stevia species (Asteraceae) have been a rich source of terpenoid compounds, mainly sesquiterpene lactones, several of which show antiprotozoal activity. In the search for new trypanocidal compounds, S. satureiifolia var. satureiifolia and S. alpina were studied. Two sesquiterpene lactones, santhemoidin C and 2-oxo-8-deoxyligustrin, respectively, were isolated. These compounds were assessed in vitro against Trypanosoma cruzi stages, showing IC50 values of 11.80 and 4.98 on epimastigotes, 56.08 and 26.19 on trypomastigotes and 4...
February 15, 2023: Pharmaceutics
#40
JOURNAL ARTICLE
Rebecca E Rieck, Joseph J Bivona, Laura R Hoyt, Sebastian Ventrone, Marta Kokoszynska, Elizabeth A Bonney, Benjamin T Suratt
OBJECTIVE: This study evaluated the effect of pregnancy on the pulmonary innate immune response in a mouse model of acute lung injury (ALI) using nebulized lipopolysaccharide (LPS). STUDY DESIGN: Pregnant (day 14) C57BL/6NCRL mice and nonpregnant controls received nebulized LPS for 15 minutes. Twenty-four hours later, mice were euthanized for tissue harvest. Analysis included blood and bronchoalveolar lavage fluid (BALF) differential cell counts, whole-lung inflammatory cytokine transcription levels by reverse transcription quantitative real-time polymerase chain reaction (RT-qPCR), and whole-lung vascular cell adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and BALF albumin by western blot...
February 16, 2023: American Journal of Perinatology
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