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https://www.readbyqxmd.com/read/28586301/definition-of-the-upper-reference-limit-of-glycated-albumin-in-blood-donors-from-italy
#1
Chiara Bellia, Martina Zaninotto, Chiara Cosma, Luisa Agnello, Bruna Lo Sasso, Giulia Bivona, Mario Plebani, Marcello Ciaccio
BACKGROUND: Glycated Albumin (GA) has been proposed as a short-term indicator of glycemic homeostasis. The aim of this study is to describe the distribution of GA in a large sample of blood donors from Italy to evaluate whether demographic features, namely age and sex, could influence GA levels and define specific reference limits. METHODS: The study included 1334 Italian blood donors. GA was measured using an enzymatic method (quantILab Glycated Albumin, IL Werfen, Germany)...
June 6, 2017: Clinical Chemistry and Laboratory Medicine: CCLM
https://www.readbyqxmd.com/read/28537389/silsesquioxane-terpyridine-nano-building-blocks-for-the-design-of-three-dimensional-polymeric-networks
#2
Esther Carbonell, Lucia A Bivona, Luca Fusaro, Carmela Aprile
Novel polyhedral oligomeric silsesquioxanes (POSS) decorated with eight terpyridine moieties were synthesized in a one-pot procedure via Heck coupling reaction with the aim of investigating the possible formation of three-dimensional extended supramolecular organizations. The monosubstituted analogue was also prepared and used as a model compound. Both POSS-based nanostructures were extensively characterized via (1)H, (13)C, and (29)Si nuclear magnetic resonance (NMR), ultraviolet-visible spectroscopies and combustion chemical analysis...
May 24, 2017: Inorganic Chemistry
https://www.readbyqxmd.com/read/28521301/activation-of-signal-transducer-and-activator-of-transcription-3-stat3-signaling-in-egfr-mutant-non-small-cell-lung-cancer-nsclc
#3
Carles Codony-Servat, Jordi Codony-Servat, Niki Karachaliou, Miguel Angel Molina, Imane Chaib, Jose Luis Ramirez, Maria de Los Llanos Gil, Flavio Solca, Trever G Bivona, Rafael Rosell
Gefitinib, erlotinib or afatinib are the current treatment for non-small-cell lung cancer (NSCLC) harboring an activating mutation of the epidermal growth factor receptor (EGFR), but less than 5% of patients achieve a complete response and the median progression-free survival is no longer than 12 months. Early adaptive resistance can occur as soon as two hours after starting treatment by activating signal transducer and activation of transcription 3 (STAT3) signaling. We investigated the activation of STAT3 in a panel of gefitinib-sensitive EGFR mutant cell lines, and gefitinib-resistant PC9 cell lines developed in our laboratory...
May 4, 2017: Oncotarget
https://www.readbyqxmd.com/read/28507205/a-case-of-metastatic-atypical-neuroendocrine-tumor-with-alk-translocation-and-diffuse-brain-metastases
#4
Victoria E Wang, Lauren Young, Siraj Ali, Vincent A Miller, Anatoly Urisman, John Wolfe, Trever G Bivona, Bertil Damato, Shannon Fogh, Emily K Bergsland
A challenge in precision medicine requires identification of actionable driver mutations. Critical to such effort is the deployment of sensitive and well-validated assays for mutation detection. Although identification of such alterations within the tumor tissue remains the gold standard, many advanced non-small cell lung cancer cases have only limited tissue samples, derived from small biopsies or fine-needle aspirates, available for testing. More recently, noninvasive methods using either circulating tumor cells or tumor DNA (ctDNA) have become an alternative method for identifying molecular biomarkers and screening patients eligible for targeted therapies...
May 15, 2017: Oncologist
https://www.readbyqxmd.com/read/28456545/galectin-3-in-acute-coronary-syndrome
#5
REVIEW
Luisa Agnello, Giulia Bivona, Bruna Lo Sasso, Concetta Scazzone, Viviana Bazan, Chiara Bellia, Marcello Ciaccio
Acute coronary syndrome (ACS) is a very common cause of hospitalizations worldwide each year. In the past decades biomarkers have become an indispensable tool for diagnosis, risk stratification and prognosis of cardiovascular disease, including ACS. Despite Troponin is considered the gold standard in diagnosis of ACS, several molecules have been investigated to identify predictive biomarkers of prognosis. Among these, Gal-3 has emerged as a promising prognostic marker. It has a pivotal role in inflammation and fibrosis...
April 26, 2017: Clinical Biochemistry
https://www.readbyqxmd.com/read/28376152/co-activation-of-stat3-and-yes-associated-protein-1-yap1-pathway-in-egfr-mutant-nsclc
#6
Imane Chaib, Niki Karachaliou, Sara Pilotto, Jordi Codony Servat, Xueting Cai, Xuefei Li, Ana Drozdowskyj, Carles Codony Servat, Jie Yang, Chunping Hu, Andres Felipe Cardona, Guillermo Lopez Vivanco, Alain Vergnenegre, Jose Miguel Sanchez, Mariano Provencio, Noemi Reguart, Caicun Zhou, Peng Cao, Patrick C Ma, Trever G Bivona, Rafael Rosell
Background: The efficacy of epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant non-small cell lung cancer (NSCLC) is limited by adaptive activation of cell survival signals. We hypothesized that both signal transducer and activator of transcription 3 (STAT3) and Src-YES-associated protein 1 (YAP1) signaling are dually activated during EGFR TKI treatment to limit therapeutic response. Methods: We used MTT and clonogenic assays, immunoblotting, and quantitative polymerase chain reaction to evaluate the efficacy of EGFR TKI alone and in combination with STAT3 and Src inhibition in three EGFR-mutant NSCLC cell lines...
September 1, 2017: Journal of the National Cancer Institute
https://www.readbyqxmd.com/read/28361810/educational-action-in-the-rehabilitation-of-severe-acquired-brain-injuries-the-role-of-self-awareness
#7
Daniela Silvestro, Maria Mazzetti, Chiara Melia, Maria Teresa Stagno, Giovanni Augusto Carlesimo, Umberto Bivona, Rita Formisano
Severe acquired brain injuries (ABI) cause a range of short-or long-term limitations in physical and neuropsychological abilities. The aim of rehabilitation is to promote the harmonious development of the individual through collaboration between medical and educational sciences, involved in the educability of the whole person, in which the aim is not only functional recovery but also social-reintegration. This "functional synergy" permits the development of the person, and establishes an indissoluble link between functions and attitudes, thus allowing the achievement of the greater possible autonomy...
January 2017: Annali Dell'Istituto Superiore di Sanità
https://www.readbyqxmd.com/read/28287179/novel-computational-method-for-predicting-polytherapy-switching-strategies-to-overcome-tumor-heterogeneity-and-evolution
#8
Vanessa D Jonsson, Collin M Blakely, Luping Lin, Saurabh Asthana, Nikolai Matni, Victor Olivas, Evangelos Pazarentzos, Matthew A Gubens, Boris C Bastian, Barry S Taylor, John C Doyle, Trever G Bivona
The success of targeted cancer therapy is limited by drug resistance that can result from tumor genetic heterogeneity. The current approach to address resistance typically involves initiating a new treatment after clinical/radiographic disease progression, ultimately resulting in futility in most patients. Towards a potential alternative solution, we developed a novel computational framework that uses human cancer profiling data to systematically identify dynamic, pre-emptive, and sometimes non-intuitive treatment strategies that can better control tumors in real-time...
March 13, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28262193/short-term-changes-in-gal-3-circulating-levels-after-acute-myocardial-infarction
#9
Giulia Bivona, Chiara Bellia, Bruna Lo Sasso, Luisa Agnello, Concetta Scazzone, Giuseppina Novo, Marcello Ciaccio
BACKGROUND AND AIMS: Galectin 3 (Gal 3) is a β-galactoside-binding lectin known to play a part in inflammation, adverse remodeling and fibrosis. Gal 3 seems to be linked to atherogenesis and Coronary Artery Disease (CAD), but less is known about the relationship between Gal 3 and acute myocardial infarction (AMI). The aim of the present study is to assess circulating levels of Gal 3 after AMI and to evaluate short-term changes of the biomarker within 5 days from the acute event. METHODS: Two hundred fifteen confirmed AMI patients (125 STEMI, M/F = 2...
October 2016: Archives of Medical Research
https://www.readbyqxmd.com/read/28059799/self-awareness-rehabilitation-after-traumatic-brain-injury-a-pilot-study-to%C3%A2-compare-two-group-therapies
#10
Jessica Rigon, Roberto Burro, Cecilia Guariglia, Manuela Maini, Dario Marin, Paola Ciurli, Umberto Bivona, Rita Formisano
BACKGROUND AND PURPOSE: Deficits of self-awareness (SA) are very common after severe acquired brain injury (sABI), especially in traumatic brain injury (TBI), playing an important role in the efficacy of the rehabilitation process. This pilot study provides information regarding two structured group therapies for disorders of SA. METHODS: Nine patients with severe TBI were consecutively recruited and randomly assigned to one SA group therapy programme, according either to the model proposed by Ben-Yishay & Lakin (1989) (B&L Group), or by Sohlberg & Mateer (1989) (S&M Group)...
2017: Restorative Neurology and Neuroscience
https://www.readbyqxmd.com/read/28055306/metastasis-from-head-to-tail
#11
Ross A Okimoto, Trever G Bivona
No abstract text is available yet for this article.
March 19, 2017: Cell Cycle
https://www.readbyqxmd.com/read/27904983/vdbp-cyp27b1-and-25-hydroxyvitamin-d-gene-polymorphism-analyses-in-a-group-of-sicilian-multiple-sclerosis-patients
#12
L Agnello, C Scazzone, B Lo Sasso, C Bellia, G Bivona, S Realmuto, F Brighina, R Schillaci, P Ragonese, G Salemi, Marcello Ciaccio
Multiple sclerosis (MS) is a chronic demyelinating disease of central nervous system regarded as one of the most common causes of neurological disability in young adults. The exact etiology of MS is not yet known, although epidemiological data indicate that both genetic susceptibility and environmental exposure are involved. A poor vitamin D status has been proposed as the most attractive environmental factor. Several evidence have highlighted the importance of mutations in vitamin D-regulating genes for vitamin D status...
April 2017: Biochemical Genetics
https://www.readbyqxmd.com/read/27869830/inactivation-of-capicua-drives-cancer-metastasis
#13
Ross A Okimoto, Frank Breitenbuecher, Victor R Olivas, Wei Wu, Beatrice Gini, Matan Hofree, Saurabh Asthana, Gorjan Hrustanovic, Jennifer Flanagan, Asmin Tulpule, Collin M Blakely, Henry J Haringsma, Andrew D Simmons, Kyle Gowen, James Suh, Vincent A Miller, Siraj Ali, Martin Schuler, Trever G Bivona
Metastasis is the leading cause of death in people with lung cancer, yet the molecular effectors underlying tumor dissemination remain poorly defined. Through the development of an in vivo spontaneous lung cancer metastasis model, we show that the developmentally regulated transcriptional repressor Capicua (CIC) suppresses invasion and metastasis. Inactivation of CIC relieves repression of its effector ETV4, driving ETV4-mediated upregulation of MMP24, which is necessary and sufficient for metastasis. Loss of CIC, or an increase in levels of its effectors ETV4 and MMP24, is a biomarker of tumor progression and worse outcomes in people with lung and/or gastric cancer...
January 2017: Nature Genetics
https://www.readbyqxmd.com/read/27852038/transcriptomic-metabolomic-reprogramming-in-egfr-mutant-nsclc-early-adaptive-drug-escape-linking-tgf%C3%AE-2-bioenergetics-mitochondrial-priming
#14
Praveena S Thiagarajan, Xiaoliang Wu, Wei Zhang, Ivy Shi, Rakesh Bagai, Patrick Leahy, Yan Feng, Martina Veigl, Daniel Lindner, David Danielpour, Lihong Yin, Rafael Rosell, Trever G Bivona, Zhenfeng Zhang, Patrick C Ma
The impact of EGFR-mutant NSCLC precision therapy is limited by acquired resistance despite initial excellent response. Classic studies of EGFR-mutant clinical resistance to precision therapy were based on tumor rebiopsies late during clinical tumor progression on therapy. Here, we characterized a novel non-mutational early adaptive drug-escape in EGFR-mutant lung tumor cells only days after therapy initiation, that is MET-independent. The drug-escape cell states were analyzed by integrated transcriptomic and metabolomics profiling uncovering a central role for autocrine TGFβ2 in mediating cellular plasticity through profound cellular adaptive Omics reprogramming, with common mechanistic link to prosurvival mitochondrial priming...
December 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27834212/preclinical-efficacy-of-a-raf-inhibitor-that-evades-paradoxical-mapk-pathway-activation-in-protein-kinase-braf-mutant-lung-cancer
#15
Ross A Okimoto, Luping Lin, Victor Olivas, Elton Chan, Evan Markegard, Andrey Rymar, Dana Neel, Xiao Chen, Golzar Hemmati, Gideon Bollag, Trever G Bivona
Oncogenic activation of protein kinase BRAF drives tumor growth by promoting mitogen-activated protein kinase (MAPK) pathway signaling. Because oncogenic mutations in BRAF occur in ∼2-7% of lung adenocarcinoma (LA), BRAF-mutant LA is the most frequent cause of BRAF-mutant cancer mortality worldwide. Whereas most tumor types harbor predominantly the BRAF(V600E)-mutant allele, the spectrum of BRAF mutations in LA includes BRAF(V600E) (∼60% of cases) and non-V600E mutant alleles (∼40% of cases) such as BRAF(G469A) and BRAF(G466V) The presence of BRAF(V600E) in LA has prompted clinical trials testing selective BRAF inhibitors such as vemurafenib in BRAF(V600E)-mutant patients...
November 22, 2016: Proceedings of the National Academy of Sciences of the United States of America
https://www.readbyqxmd.com/read/27736114/-just-be-a-light-experiences-of-peers-working-on-acute-inpatient-psychiatric-units
#16
Thomas E Smith, Maria Abraham, Michael Bivona, Myles J Brakman, Isaac S Brown, Gita Enders, Sara Goodman, Liam McNabb, Joseph W Swinford
Objective: The study aimed to clarify the potential role and impact of behavioral health peer support providers on community hospital acute inpatient psychiatric units. Method: Qualitative interviews were conducted to examine perspectives of peer support providers (peers) and individuals who initially received peer services (recipients) during an inpatient stay on a community hospital psychiatric unit. Interviews elicited perspectives on interactions between peers and recipients, the role of peers vis-à-vis the clinical treatment team, and involvement of peers in discharge planning and transitions to community-based care...
October 13, 2016: Psychiatric Rehabilitation Journal
https://www.readbyqxmd.com/read/27728891/comparison-of-postoperative-venous-thromboembolism-incidence-in-gastrointestinal-and-gynecologic-solid-tumors
#17
COMPARATIVE STUDY
Tina Melancon, Cory Bivona, Susan Klenke, Michelle Rockey, Jane Huh, Dave Henry, Dennis Grauer, Mazin Al-Kasspooles, Gary Johnson, Evelyn Reynolds, Julia Chapman
INTRODUCTION: Studies have shown the benefit of 28days of extended postoperative venous thromboembolism (VTE) prophylaxis for patients undergoing major cancer surgery in the abdomen or pelvis. We retrospectively evaluated the VTE incidence at the University of Kansas Hospital between gynecologic (GYN) cancer patients, who receive extended prophylaxis, and gastrointestinal (GI) cancer patients, who do not. METHODS: Patients were evaluated between January of 2010 and December of 2013, and VTE data for eligible patients were collected for 30 and 90days postoperatively...
November 2016: Thrombosis Research
https://www.readbyqxmd.com/read/27686974/hsp70-dependence-in-rhabdomyosarcoma-seed-or-soil
#18
Amit J Sabnis, Trever G Bivona
No abstract text is available yet for this article.
January 17, 2017: Cell Cycle
https://www.readbyqxmd.com/read/27686362/quality-of-life-after-brain-injury-qolibri-italian-validation-of-the-proxy-version
#19
Rita Formisano, Daniela Silvestro, Eva Azicnuda, Eloïse Longo, Carmen Barba, Jessica Rigon, Mariagrazia D'Ippolito, Marco Giustini, Umberto Bivona
To validate the proxy version of the Quality of Life after Brain Injury (QOLIBRI) questionnaire to utilize caregivers for comparison and to evaluate the correspondence between patients' self-perceived and caregivers' perception of patients' Health-Related Quality of Life (HRQoL). Ninety-two patients with severe TBI and their main caregivers were enrolled. Patients' and caregivers' HRQoL was assessed by the Patient-QOLIBRI (Pt-QOLIBRI) and the Proxy-QOLIBRI (Pro-QOLIBRI), respectively. The Pro-QOLIBRI is a modified version of the QOLIBRI to investigate caregivers' perception of patients' HRQoL (Pro-QOLIBRIpatient-centered), and their degree of satisfaction and botheredness (Pro-QOLIBRIcaregiver centered)...
September 29, 2016: Internal and Emergency Medicine
https://www.readbyqxmd.com/read/27478041/salt-inducible-kinase-2-couples-ovarian-cancer-cell-metabolism-with-survival-at-the-adipocyte-rich-metastatic-niche
#20
Fabrizio Miranda, David Mannion, Shujuan Liu, Yiyan Zheng, Lingegowda S Mangala, Clara Redondo, Sandra Herrero-Gonzalez, Ruoyan Xu, Charlotte Taylor, Donatien Fotso Chedom, Mohammad Karaminejadranjbar, Ashwag Albukhari, Dahai Jiang, Sunila Pradeep, Cristian Rodriguez-Aguayo, Gabriel Lopez-Berestein, Eidarus Salah, Kamal R Abdul Azeez, Jonathan M Elkins, Leticia Campo, Kevin A Myers, Daniel Klotz, Serena Bivona, Sunanda Dhar, Robert C Bast, Hideyuki Saya, Hwan Geun Choi, Nathanael S Gray, Roman Fischer, Benedikt M Kessler, Christopher Yau, Anil K Sood, Takeshi Motohara, Stefan Knapp, Ahmed Ashour Ahmed
The adipocyte-rich microenvironment forms a niche for ovarian cancer metastasis, but the mechanisms driving this process are incompletely understood. Here we show that salt-inducible kinase 2 (SIK2) is overexpressed in adipocyte-rich metastatic deposits compared with ovarian primary lesions. Overexpression of SIK2 in ovarian cancer cells promotes abdominal metastasis while SIK2 depletion prevents metastasis in vivo. Importantly, adipocytes induce calcium-dependent activation and autophosphorylation of SIK2...
August 8, 2016: Cancer Cell
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