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https://www.readbyqxmd.com/read/28717527/vagal-paraganglioma-presenting-as-a-neck-mass-associated-with-cough-on-palpation
#1
Richard Heyes, Nizar Taki, Miriam A O'Leary
A 70-year-old female presented with a neck mass and sporadic dry cough, often leading to fits of coughing severe enough to cause vomiting. The patient reported that touching the mass triggered the cough. On examination, a 2.5 cm right-sided level two neck mass deep to the sternocleidomastoid was present. Palpation of the mass immediately triggered coughing. Cross-sectional imaging proposed vagal paraganglioma as the chief differential, which was confirmed following surgical excision. The patient reported complete resolution of her severe dry cough after surgery...
2017: Case Reports in Otolaryngology
https://www.readbyqxmd.com/read/28717525/differential-effects-of-awake-glioma-surgery-in-critical-language-areas-on-cognition-4-case-studies
#2
Djaina Satoer, Elke De Witte, Marion Smits, Roelien Bastiaanse, Arnaud Vincent, Peter Mariën, Evy Visch-Brink
Awake surgery with electrocorticosubcortical stimulation is the golden standard treatment for gliomas in eloquent areas. Preoperatively, mostly mild cognitive disturbances are observed with postoperative deterioration. We describe pre- and postoperative profiles of 4 patients (P1-P4) with gliomas in "critical" language areas ("Broca," "Wernicke," and the arcuate fasciculus) undergoing awake surgery to get insight into the underlying mechanism of neuroplasticity. Neuropsychological examination was carried out preoperatively (at T1) and postoperatively (at T2, T3)...
2017: Case Reports in Neurological Medicine
https://www.readbyqxmd.com/read/28714784/the-management-of-paediatric-neurogenic-bladder-an-approach-in-a-resource-poor-setting
#3
Patrick Opoku Manu Maison, John Lazarus
BACKGROUND: If untreated, paediatric neurogenic bladder can cause renal failure and urinary incontinence. It is usually caused by neural tube defects such as myelomeningocele. Children with a neurogenic bladder should be monitored from birth and management should aim to preserve renal function and achieve social continence. This article outlines the management options appropriate for these children in resource-poor settings. ASSESSMENT: In most low- and middle-income countries, a general lack of awareness of the neurological effects on the urinary tract results in late presentation, usually with urological complications even when spina bifida is diagnosed early...
July 17, 2017: Paediatrics and International Child Health
https://www.readbyqxmd.com/read/28713053/perils-of-intraoperative-neurophysiologic-monitoring-analysis-of-false-negative-results-in-spine-surgeries
#4
Arvydas Tamkus, Kent S Rice, Michael McCaffrey
BACKGROUND CONTEXT: Although some authors published case reports describing false negatives in intraoperative neurophysiologic monitoring (IONM), systematic review of causes of false negative IONM results is lacking. PURPOSE: The objective was to analyze false negative IONM findings in spine surgery. STUDY DESIGN: Retrospective cohort analysis PATIENT SAMPLE: A cohort of 109 patients with new postoperative neurological deficits was analyzed for possible false negative IONM reporting...
July 13, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28711563/application-of-neurite-orientation-dispersion-and-density-imaging-or-diffusion-tensor-imaging-to-quantify-the-severity-of-cervical-spondylotic-myelopathy-and-assess-postoperative-neurological-recovery
#5
Genki Okita, Tetsuro Ohba, Tomohiro Takamura, Shigeto Ebata, Ryo Ueda, Hiroshi Onishi, Hirotaka Haro, Masaaki Hori
BACKGROUND CONTEXT: Surgical outcome and the severity of cervical spondylotic myelopathy (CSM) are unpredictable and cannot be estimated by conventional anatomical MRI. The utility of diffusion tensor imaging (DTI) to quantify the severity of CSM and assess postoperative neurological recovery has been investigated. However, whether conventional DTI should be applied in a clinical setting remains controversial. Neurite orientation dispersion and density imaging (NODDI) is a recently introduced model-based diffusion-weighted MRI technique that quantifies specific microstructural features related directly to neuronal morphology...
July 12, 2017: Spine Journal: Official Journal of the North American Spine Society
https://www.readbyqxmd.com/read/28710025/inhibitory-effects-of-tetramethylpyrazine-on-pain-transmission-of-trigeminal-neuralgia-in-cci-ion-rats
#6
Wei Xiong, Mengxia Tan, Lingkun He, Xiaoyan Ou, Youhong Jin, Guo Yang, Liping Huang, Yulin Shen, Shu Guan, Changshui Xu, Guilin Li, Shuangmei Liu, Hong Xu, Shangdong Liang, Yun Gao
Tetramethylpyrazine (TMP) has anti-inflammatory effects and is used to treat cerebral ischemic injury, but the mechanism of TMP on neural protection is not clear. Trigeminal neuralgia (TN) is a facial pain syndrome that is characterized by paroxysmal, shock-like pain attacks located in the somatosensory distribution of the trigeminal nerve. P2X3 receptor plays a crucial role in facilitating pain transmission. The present study investigates the effects of TMP on trigeminal neuralgia transmission mediated by P2X3 receptor of the trigeminal ganglia (TG)...
July 11, 2017: Brain Research Bulletin
https://www.readbyqxmd.com/read/28707698/cost-effectiveness-of-intraoperative-nerve-monitoring-in-avoidance-of-bilateral-recurrent-laryngeal-nerve-injury-in-patients-undergoing-total-thyroidectomy
#7
Z Al-Qurayshi, E Kandil, G W Randolph
BACKGROUND: Intraoperative nerve monitoring (IONM) provides dynamic neural information and is recommended for high-risk thyroid surgery. In this analysis, the cost-effectiveness of IONM in preventing bilateral recurrent laryngeal nerve (RLN) injury was investigated. METHODS: A Markov chain model was constructed based on IONM use. The base-case patient was defined as a 40-year-old woman presenting with a 4·1-cm left-sided papillary thyroid cancer who developed RLN injury with loss of monitoring signal during planned bilateral thyroidectomy...
July 14, 2017: British Journal of Surgery
https://www.readbyqxmd.com/read/28706574/neuronal-damage-induced-by-perinatal-asphyxia-is-attenuated-by-postinjury-glutaredoxin-2-administration
#8
Juan Ignacio Romero, Mariana Inés Holubiec, Tamara Logica Tornatore, Stéphanie Rivière, Eva-Maria Hanschmann, Rodolfo Alberto Kölliker-Frers, Julia Tau, Eduardo Blanco, Pablo Galeano, Fernando Rodríguez de Fonseca, Christopher Horst Lillig, Francisco Capani
The general disruption of redox signaling following an ischemia-reperfusion episode has been proposed as a crucial component in neuronal death and consequently brain damage. Thioredoxin (Trx) family proteins control redox reactions and ensure protein regulation via specific, oxidative posttranslational modifications as part of cellular signaling processes. Trx proteins function in the manifestation, progression, and recovery following hypoxic/ischemic damage. Here, we analyzed the neuroprotective effects of postinjury, exogenous administration of Grx2 and Trx1 in a neonatal hypoxia/ischemia model...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28701933/network-efficiency-and-posterior-alpha-patterns-are-markers-of-recovery-from-general-anesthesia-a-high-density-electroencephalography-study-in-healthy-volunteers
#9
Stefanie Blain-Moraes, Vijay Tarnal, Giancarlo Vanini, Tarik Bel-Behar, Ellen Janke, Paul Picton, Goodarz Golmirzaie, Ben J A Palanca, Michael S Avidan, Max B Kelz, George A Mashour
Recent studies have investigated local oscillations, long-range connectivity, and global network patterns to identify neural changes associated with anesthetic-induced unconsciousness. These studies typically employ anesthetic protocols that either just cross the threshold of unconsciousness, or induce deep unconsciousness for a brief period of time-neither of which models general anesthesia for major surgery. To study neural patterns of unconsciousness and recovery in a clinically-relevant context, we used a realistic anesthetic regimen to induce and maintain unconsciousness in eight healthy participants for 3 h...
2017: Frontiers in Human Neuroscience
https://www.readbyqxmd.com/read/28695342/thyroid-nodule-classification-in-ultrasound-images-by-fine-tuning-deep-convolutional-neural-network
#10
Jianning Chi, Ekta Walia, Paul Babyn, Jimmy Wang, Gary Groot, Mark Eramian
With many thyroid nodules being incidentally detected, it is important to identify as many malignant nodules as possible while excluding those that are highly likely to be benign from fine needle aspiration (FNA) biopsies or surgeries. This paper presents a computer-aided diagnosis (CAD) system for classifying thyroid nodules in ultrasound images. We use deep learning approach to extract features from thyroid ultrasound images. Ultrasound images are pre-processed to calibrate their scale and remove the artifacts...
July 10, 2017: Journal of Digital Imaging: the Official Journal of the Society for Computer Applications in Radiology
https://www.readbyqxmd.com/read/28690952/targeted-radiofrequency-ablation-as-an-adjunct-in-treatment-of-lumbar-facet-cysts
#11
Jesse Hatgis, Michelle Granville, Aldo Berti, Robert E Jacobson
Lumbar facet cysts are frequently found in patients with facet degeneration and segmental instability. When the facet cyst is localized in the neural foramina and lateral recess or becomes large, it can cause radiculopathy or neurogenic claudication. These symptomatic cysts are typically treated interventionally with drainage and a corticosteroid injection or attempts via overinflation to rupture the cyst; however, these procedures have a significant recurrence rate (up to 50%) and often need to be repeated or lead to lumbar surgery if unsuccessful...
June 6, 2017: Curēus
https://www.readbyqxmd.com/read/28689390/usefulness-of-end-to-side-bridging-anastomosis-of-sural-nerve-to-tibial-nerve-an-experimental-research
#12
Soner Civi, Emre Durdag, Murat Hamit Aytar, Ozgur Kardes, Figen Kaymaz, Sukru Aykol
OBJECTIVE: Repair of sensorial nerve defect is an important issue on peripheric nerve surgery. The aim of the present study was to determine the effects of sensory-motor nerve bridging on the denervated dermatomal area, in rats with sensory nerve defects, using a neural cell adhesion molecule (NCAM). METHODS: We compared the efficacy of end-to-side (ETS) coaptation of the tibial nerve for sural nerve defect repair, in 32 Sprague-Dawley rats. Rats were assigned to 1 of 4 groups: group A was the sham operated group, group B rats had sural nerves sectioned and buried in neighboring muscles, group C experienced nerve sectioning and end-to-end (ETE) anastomosis, and group D had sural nerves sectioned and ETS anastomosis was performed using atibial nerve bridge...
July 2017: Journal of Korean Neurosurgical Society
https://www.readbyqxmd.com/read/28689337/osteoid-osteoma-of-the-hand-and-foot-in-children-successfully-treated-with-radiofrequency-neurotomy-probes
#13
Gokhan Kuyumcu, Murali Sundaram, Jean P Schils, Hakan Ilaslan
Osteoid osteoma is a common benign tumor that is typically found in young adults and children, usually in the long bones of the lower extremity. Radiofrequency ablation (RFA) under computed tomography guidance is the standard of care for symptomatic osteoid osteomas. However, patients with osteoid osteoma of the hand or foot are often treated with open surgery because of the risk of injury to vascular and neural structures from RFA. This risk is more pronounced in pediatric patients because of the small lesion size and proximity of lesions to important neurovascular structures...
July 8, 2017: Skeletal Radiology
https://www.readbyqxmd.com/read/28688624/indirect-decompression-in-spinal-surgery
#14
REVIEW
Hiroyuki Yoshihara
Indirect decompression in spinal surgery means decompression of spinal nerve tissues, such as spinal cord and nerve, without resecting the compressing tissue. Indirect spinal decompression procedures largely can be divided into segmental procedures and global spinal alignment procedures. Segmental procedures are mainly performed by the distraction between two vertebrae, which lead to the opening of the neural foramen and increases the epidural space. Such distraction can be performed through the disc space or using posterior instrumentation...
July 5, 2017: Journal of Clinical Neuroscience: Official Journal of the Neurosurgical Society of Australasia
https://www.readbyqxmd.com/read/28686146/synovial-cysts-of-the-spine-long-term-follow-up-after-surgical-treatment-of-141-cases-in-a-single-center-series-and-comprehensive-literature-review-of-2900-degenerative-spinal-cysts
#15
Markus Bruder, Adriano Cattani, Florian Gessler, Christian Droste, Matthias Setzer, Volker Seifert, Gerhard Marquardt
OBJECTIVE Synovial cysts of the spine are rare lesions, predominantly arising in the lumbar region. Despite their generally benign behavior, they can cause severe symptoms due to compression of neural structures in the spinal canal. Treatment strategies are still a matter of discussion. The authors performed a single-center survey and literature search focusing on long-term results after minimally invasive surgery. METHODS A total of 141 consecutive patients treated for synovial cysts of the lumbar spine between 1997 and 2014 in the authors' department were analyzed...
July 7, 2017: Journal of Neurosurgery. Spine
https://www.readbyqxmd.com/read/28685029/does-gastric-bypass-surgery-change-body-weight-set-point
#16
REVIEW
Z Hao, M B Mumphrey, C D Morrison, H Münzberg, J Ye, H R Berthoud
The relatively stable body weight during adulthood is attributed to a homeostatic regulatory mechanism residing in the brain which uses feedback from the body to control energy intake and expenditure. This mechanism guarantees that if perturbed up or down by design, body weight will return to pre-perturbation levels, defined as the defended level or set point. The fact that weight re-gain is common after dieting suggests that obese subjects defend a higher level of body weight. Thus, the set point for body weight is flexible and likely determined by the complex interaction of genetic, epigenetic and environmental factors...
December 2016: International Journal of Obesity Supplements
https://www.readbyqxmd.com/read/28672008/nanofibrous-scaffolds-for-the-guidance-of-stem-cell-derived-neurons-for-auditory-nerve-regeneration
#17
Sandra Hackelberg, Samuel J Tuck, Long He, Arjun Rastogi, Christina White, Liqian Liu, Diane M Prieskorn, Ryan J Miller, Che Chan, Benjamin R Loomis, Joseph M Corey, Josef M Miller, R Keith Duncan
Impairment of spiral ganglion neurons (SGNs) of the auditory nerve is a major cause for hearing loss occurring independently or in addition to sensory hair cell damage. Unfortunately, mammalian SGNs lack the potential for autonomous regeneration. Stem cell based therapy is a promising approach for auditory nerve regeneration, but proper integration of exogenous cells into the auditory circuit remains a fundamental challenge. Here, we present novel nanofibrous scaffolds designed to guide the integration of human stem cell-derived neurons in the internal auditory meatus (IAM), the foramen allowing passage of the spiral ganglion to the auditory brainstem...
2017: PloS One
https://www.readbyqxmd.com/read/28671770/clinical-outcomes-of-patients-with-resectable-pancreatic-acinar-cell-carcinoma
#18
Seyoung Seo, Changhoon Yoo, Kyu-Pyo Kim, Baek-Yeol Ryoo, Heung-Moon Chang, Seung-Mo Hong, Jae Hoon Lee, Ki Byung Song, Dae Wook Hwang, Ki-Hun Kim, Shin Hwang, Song Cheol Kim
AIM: With rarity of disease, the post-resection clinical course of localized pancreatic acinar cell carcinoma (ACC) is largely unknown. Therefore, we analyzed the outcomes of patients with localized pancreatic ACCs who underwent surgical resection. METHODS: We retrospectively analyzed the outcomes of 20 patients with resectable pancreatic ACC who underwent surgery. RESULTS: Median age was 57 years and 16 were male. The ACCs were composed of 8 pure ACCs, 10 mixed acinar-neuroendocrine carcinomas, and 2 mixed acinar-ductal adenocarcinomas...
July 3, 2017: Journal of Digestive Diseases
https://www.readbyqxmd.com/read/28671554/a-machine-learning-based-analysis-for-the-recognition-of-progressive-central-hypovolemia
#19
Frank Cornelis Bennis, Björn Van der Ster, Johannes Van Lieshout, Peter Andriessen, Tammo Delhaas
Traditional patient monitoring during surgery include heart rate (HR), blood pressure (BP) and peripheral oxygen saturation. However, their use as predictors for central hypovolemia is limited, which may lead to cerebral hypoperfusion. The aim of this study was to develop a monitoring model that can indicate a decrease in central blood volume (CBV) in an early stage. Approach: Twenty-eight healthy subjects (age 18-50 yr) were included. Lower body negative pressure (-50 mmHg) was applied to induce central hypovolemia until onset of pre-syncope...
July 3, 2017: Physiological Measurement
https://www.readbyqxmd.com/read/28665814/investigation-of-slow-wave-activity-saturation-during-surgical-anesthesia-reveals-a-signature-of-neural-inertia-in-humans
#20
Catherine E Warnaby, Jamie W Sleigh, Darren Hight, Saad Jbabdi, Irene Tracey
BACKGROUND: Previously, we showed experimentally that saturation of slow-wave activity provides a potentially individualized neurophysiologic endpoint for perception loss during anesthesia. Furthermore, it is clear that induction and emergence from anesthesia are not symmetrically reversible processes. The observed hysteresis is potentially underpinned by a neural inertia mechanism as proposed in animal studies. METHODS: In an advanced secondary analysis of 393 individual electroencephalographic data sets, we used slow-wave activity dose-response relationships to parameterize slow-wave activity saturation during induction and emergence from surgical anesthesia...
June 30, 2017: Anesthesiology
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