keyword
https://read.qxmd.com/read/38535827/botulinum-toxin-injections-to-manage-sequelae-of-peripheral-facial-palsy
#21
REVIEW
Fabienne Carré, Jérémy Amar, Frédéric Tankéré, Claire Foirest
Long-standing facial palsy sequelae cause functional, aesthetic, and psychological problems in patients. Botulinum toxin is an effective way to manage them, but no standardized recommendations exist. Through this non-systematic review, we aimed to guide any practitioner willing to master the ins and outs of this activity. We reviewed the existing literature and completed, with our experience as a reference center, different strategies of botulinum toxin injections used in facial palsy patients, including history, physiopathology, facial analysis, dosages, injection sites, and techniques, as well as time intervals between injections...
March 20, 2024: Toxins
https://read.qxmd.com/read/38535819/botulinum-toxin-for-pain-relief-in-cancer-patients-a-systematic-review-of-randomized-controlled-trials
#22
REVIEW
Lorenzo Lippi, Alessandro de Sire, Alessio Turco, Martina Ferrillo, Serdar Kesikburun, Alessio Baricich, Stefano Carda, Marco Invernizzi
Cancer pain is one of the most disabling symptoms complained by cancer patients, with a crucial impact on physical and psychological well-being. Botulinum neurotoxins (BoNTs) type A and B have emerged as potential interventions for chronic pain; however, their role in these patients is still debated. Thus, this systematic review of randomized controlled trials aimed at assessing the effects of BoNT treatment for cancer pain to guide physicians in an evidence-based approach integrating BoNT in cancer care. Out of 5824 records, 10 RCTs satisfied our eligibility criteria and were included in the present work for a total of 413 subjects with several cancer types (breast, head and neck, esophageal, and thoracic/gastric cancers)...
March 15, 2024: Toxins
https://read.qxmd.com/read/38535806/impact-of-botulinum-toxin-injections-on-quality-of-life-of-patients-with-long-standing-peripheral-facial-palsy
#23
JOURNAL ARTICLE
Jérémy Amar, Frédéric Tankere, Diane Picard, Lauranne Alciato, Fabienne Carré, Claire Foirest
(1) Background: Sequels of facial palsy lead to major psychosocial repercussions, disrupting patients' quality of life (QoL). Botulinum toxin (BoNT) injections can permit us to treat long-standing facial palsy, improving facial symmetry and functional signs including synkinesis and contractures. (2) Methods: The main aim of this study was to assess the evolution of the QoL for patients with long-standing facial palsy before, at 1 month, and at 4 months after BoNT injections by using three questionnaires (HFS-30, FaCE, and HAD)...
March 8, 2024: Toxins
https://read.qxmd.com/read/38535789/real-life-treatment-outcome-of-botulinum-toxin-a-injection-on-overactive-bladder-and-voiding-dysfunction-in-patients-with-central-nervous-system-lesions
#24
JOURNAL ARTICLE
Yuan-Hong Jiang, Jia-Fong Jhang, Sheng-Fu Chen, Hann-Chorng Kuo
PURPOSE: Neurogenic lower urinary tract dysfunction (NLUTD) is common in patients with neurological lesions in the central nervous system (CNS). Medical treatment usually cannot adequately relieve NLUTD. This study reported the real-life treatment outcome of botulinum toxin A (BoNT-A) for overactive bladders (OAB) and voiding dysfunction in patients with CNS lesions. METHODS: We retrospectively analyzed the first-time treatment outcome of 74 patients who received detrusor 100 U BoNT-A for OAB and 45 patients who received a urethral sphincter 100 U BoNT-A injection for voiding dysfunction...
March 1, 2024: Toxins
https://read.qxmd.com/read/38535774/ct-arthrography-of-the-elbow-what-radiologists-should-know
#25
REVIEW
Gianluca Folco, Carmelo Messina, Salvatore Gitto, Stefano Fusco, Francesca Serpi, Andrea Zagarella, Mauro Battista Gallazzi, Paolo Arrigoni, Alberto Aliprandi, Marco Porta, Paolo Vitali, Luca Maria Sconfienza, Domenico Albano
Computed tomography (CT) arthrography is a quickly available imaging modality to investigate elbow disorders. Its excellent spatial resolution enables the detection of subtle pathologic changes of intra-articular structures, which makes this technique extremely valuable in a joint with very tiny chondral layers and complex anatomy of articular capsule and ligaments. Radiation exposure has been widely decreased with the novel CT scanners, thereby increasing the indications of this examination. The main applications of CT arthrography of the elbow are the evaluation of capsule, ligaments, and osteochondral lesions in both the settings of acute trauma, degenerative changes, and chronic injury due to repeated microtrauma and overuse...
March 11, 2024: Tomography: a Journal for Imaging Research
https://read.qxmd.com/read/38535687/characterization-of-mn-5-ge-3-contacts-on-a-shallow-ge-sige-heterostructure
#26
JOURNAL ARTICLE
Troy A Hutchins-Delgado, Sadhvikas J Addamane, Ping Lu, Tzu-Ming Lu
Mn5Ge3 is a ferromagnetic phase of the Mn-Ge system that is a potential contact material for efficient spin injection and detection. Here, we investigate the creation of Mn5Ge3-based contacts on a Ge/SiGe quantum well heterostructure via solid-state synthesis. X-ray diffraction spectra fitting indicates the formation of Mn5Ge3-based contacts on bulk Ge and Ge/SiGe. High-resolution scanning transmission electron microscopy imaging and energy dispersive X-ray spectroscopy verify the correct Mn5Ge3-based phase formation...
March 19, 2024: Nanomaterials
https://read.qxmd.com/read/38535482/high-precision-characterization-of-quantum-cascade-laser-frequency-response-using-wavelength-modulation-spectroscopy
#27
JOURNAL ARTICLE
M H Hlaing, Caio Azevedo, M Amir Khan
This paper investigates the impact of the quantum cascade laser's frequency modulation response on its tuning rate and tunability. We show a significant disparity in laser tuning rates and tunability between single and dual-frequency modulation schemes frequently used in typical direct absorption and wavelength modulation spectroscopy (WMS) techniques. We show that the DC-characterized tuning rate of a laser can be reduced significantly under a specific set of modulation frequencies of the laser injection current...
March 1, 2024: Review of Scientific Instruments
https://read.qxmd.com/read/38535470/a-review-of-cyclic-imines-in-shellfish-worldwide-occurrence-toxicity-and-assessment-of-the-risk-to-consumers
#28
REVIEW
Sarah C Finch, D Tim Harwood, Michael J Boundy, Andrew I Selwood
Cyclic imines are a class of lipophilic shellfish toxins comprising gymnodimines, spirolides, pinnatoxins, portimines, pteriatoxins, prorocentrolides, spiro-prorocentrimine, symbiomines and kabirimine. They are structurally diverse, but all share an imine moiety as part of a bicyclic ring system. These compounds are produced by marine microalgal species and are characterized by the rapid death that they induce when injected into mice. Cyclic imines have been detected in a range of shellfish species collected from all over the world, which raises the question as to whether they present a food safety risk...
March 11, 2024: Marine Drugs
https://read.qxmd.com/read/38535440/a-standardized-extract-of-microalgae-phaeodactylum-tricornutum-mi136-inhibit-d-gal-induced-cognitive-dysfunction-in-mice
#29
JOURNAL ARTICLE
Jonathan Maury, Antoine Delbrut, Vanessa Villard, Rémi Pradelles
The microalgae Phaeodactylum tricornutum (PT) is distinguished by its rich nutrient profile, characterized by well-documented neuroprotective activities, including fucoxanthin (FX), a major carotenoid and polyunsaturated omega-3 fatty acids (n-3 PUFA). The current study aims to evaluate the protective effects of a standardized extract of PT (Mi136) containing 2% FX on cognitive function, oxidative stress, and inflammation parameters in a mouse model of accelerated aging. Seventy-two (72) male mice were randomly assigned to the blank control group (BC), negative control group (NC), and four similar microalgae extract of PT groups (branded as BrainPhyt™) with different human equivalent doses to evaluate potential dose-response effects...
February 21, 2024: Marine Drugs
https://read.qxmd.com/read/38535407/a-c-type-lectin-rfctl27-activates-the-immune-defense-in-the-red-palm-weevil-rhynchophorus-ferrugineus-a-g-olivier-1791-coleoptera-curculionidae-dryophthorinae-by-the-recognition-of-gram-negative-bacteria
#30
JOURNAL ARTICLE
Yanru Gong, Yongjian Xia, Zhiping Su, Xinghong Wang, Yishuo Kou, Bing Ma, Youming Hou, Zhanghong Shi
Red palm weevil, Rhynchophorus ferrugineus (Olivier), is a palm tree insect pest that causes significant damage in the many countries from the Indian sub-continent and southeast Asia into date palm-growing countries of Africa, the Middle East, and the Mediterranean Basin. This study is aimed at determining the role of a C-type lectin, RfCTL27, in the immune defense of RPW larvae. RfCTL27 is a secreted protein that possesses a QPD motif, being integral for the discrimination of Gram-negative bacteria. The abundance of RfCTL27 transcripts in the gut and fat body was significantly higher than that in other tissues...
March 21, 2024: Insects
https://read.qxmd.com/read/38535357/histone-acetylation-enhancing-host-melanization-in-response-to-parasitism-by-an-endoparasitoid-wasp
#31
JOURNAL ARTICLE
Kun Jiang, Yan Zhou, Wen Cui, Yan-Wei Han, Pei Chen, Gui-Ming Liao, You-Ming Hou, Bao-Zhen Tang
Endoparasitoids are insects that develop within other insects, employing unique strategies to enhance their offspring's survival. They inject polydnavirus and/or venom into their hosts along with eggs, effectively suppressing the host's immune system. Polydnavirus from Braconidae and Ichneumonidae wasps can integrate into the host's genome to express viral genes using the host's transcription systems. However, the ability of parasitoids without polydnavirus to manipulate host gene expression remains unclear...
February 27, 2024: Insects
https://read.qxmd.com/read/38535338/knockdown-of-the-expression-of-two-trehalase-genes-with-rnai-disrupts-the-trehalose-and-chitin-metabolism-pathways-in-the-oriental-armyworm-mythimna-separata
#32
JOURNAL ARTICLE
Hongjia Yang, Yixiao Wang, Weijia Zhang, Xinxin Zhang, Sibo Wang, Mengyao Cui, Xiaohui Zhao, Dong Fan, Changchun Dai
Trehalose is an important carbohydrate substance in insect hemolymph. Chitin is the main component of cuticle and peritrophic matrix in insects. Trehalase (Tre) catalyzes the decomposition of trehalose. Few studies of trehalase in lepidopteran insects have been conducted. Here, the functions of soluble Tre (Tre1) and membrane-bound Tre (Tre2) in the growth and development of Mythimna separata were investigated. We cloned and identified Tre1 and Tre2 cDNA sequences in M. separata . Analysis expression revealed that MsTre1 and MsTre2 were highly expressed in midgut and integument, respectively...
February 21, 2024: Insects
https://read.qxmd.com/read/38535316/daily-injection-of-the-%C3%AE-2-adrenergic-agonist-clenbuterol-improved-muscle-glucose-metabolism-glucose-stimulated-insulin-secretion-and-hyperlipidemia-in-juvenile-lambs-following-heat-stress-induced-intrauterine-growth-restriction
#33
JOURNAL ARTICLE
Rachel L Gibbs, James A Wilson, Rebecca M Swanson, Joslyn K Beard, Zena M Hicks, Haley N Beer, Eileen S Marks-Nelson, Ty B Schmidt, Jessica L Petersen, Dustin T Yates
Stress-induced fetal programming diminishes β2 adrenergic tone, which coincides with intrauterine growth restriction ( IUGR ) and lifelong metabolic dysfunction. We determined if stimulating β2 adrenergic activity in IUGR-born lambs would improve metabolic outcomes. IUGR lambs that received daily injections of saline or the β2 agonist clenbuterol from birth to 60 days were compared with controls from pair-fed thermoneutral pregnancies. As juveniles, IUGR lambs exhibited systemic inflammation and robust metabolic dysfunction, including greater ( p < 0...
March 7, 2024: Metabolites
https://read.qxmd.com/read/38535259/bone-marrow-derived-mesenchymal-stem-cell-laden-nanocomposite-scaffolds-enhance-bone-regeneration-in-rabbit-critical-size-segmental-bone-defect-model
#34
JOURNAL ARTICLE
Elangovan Kalaiselvan, Swapan Kumar Maiti, Shivaraju Shivaramu, Shajahan Amitha Banu, Khan Sharun, Divya Mohan, Sangeetha Palakkara, Sadhan Bag, Monalisa Sahoo, Suresh Ramalingam, Jürgen Hescheler
Bone regeneration poses a significant challenge in the field of tissue engineering, prompting ongoing research to explore innovative strategies for effective bone healing. The integration of stem cells and nanomaterial scaffolds has emerged as a promising approach, offering the potential to enhance regenerative outcomes. This study focuses on the application of a stem cell-laden nanomaterial scaffold designed for bone regeneration in rabbits. The in vivo study was conducted on thirty-six healthy skeletally mature New Zealand white rabbits that were randomly allocated into six groups...
March 10, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535252/injectable-micro-hydrogel-for-dna-delivery-a-promising-therapeutic-platform
#35
JOURNAL ARTICLE
Sunghyun Moon, Jong Bum Lee
Utilizing the immune system as a strategy for disease prevention and treatment is promising, especially with dendritic cells (DCs) playing a central role in adaptive immune responses. The unique properties of DCs drive interest in developing materials for cell-based therapy and immune modulation. Injectable systems require syringe-compatible scaffolds, while hydrogels, like alginate, known for their programmability and biocompatibility, offer a versatile platform for immune medicine enhancement through easy preparation and room-temperature cross-linking...
March 1, 2024: Journal of Functional Biomaterials
https://read.qxmd.com/read/38535140/development-of-a-micro-ct-scanner-with-dual-energy-option-and-endovascular-contrast-agent-administration-protocol-for-fetal-and-neonatal-virtual-autopsy
#36
JOURNAL ARTICLE
Robert Zboray, Wolf Schweitzer, Lars Ebert, Martin Wolf, Sabino Guglielmini, Stefan Haemmerle, Stephan Weiss, Bruno Koller
The rate of parental consent for fetal and perinatal autopsy is decreasing, whereas parents are more likely to agree to virtual autopsy by non-invasive imaging methods. Fetal and perinatal virtual autopsy needs high-resolution and good soft-tissue contrast for investigation of the cause of death and underlying trauma or pathology in fetuses and stillborn infants. This is offered by micro-computed tomography (CT), as opposed to the limited resolution provided by clinical CT scanners, and this is one of the most promising tools for non-invasive perinatal postmortem imaging...
February 29, 2024: Journal of Imaging
https://read.qxmd.com/read/38535083/a-histological-evaluation-of-the-efficiency-of-using-periprosthetic-autologous-fat-to-prevent-capsular-contracture-compared-to-other-known-methods-an-experimental-study
#37
JOURNAL ARTICLE
Mihaela Pertea, Nadia Aladari, Oxana Madalina Grosu, Stefana Luca, Raluca Tatar, Andrei-Nicolae Avadanei, Madalina Palaghia, Ana Maria Trofin, Sorinel Lunca, Nina Filip
BACKGROUND: Capsular contracture remains a common complication in silicone breast implantation. The etiology, formation mechanisms, predisposing and favoring factors are still subjects of research. This study aims to demonstrate the effectiveness of using autologous fat introduced periprosthetically in preventing capsular contracture compared to other known methods: antibiotics and corticosteroids. METHODS: A cohort of 80 Wistar rats was included in the study, divided into four subgroups...
March 21, 2024: Diagnostics
https://read.qxmd.com/read/38534748/use-of-collagen-in-cosmetic-products
#38
REVIEW
Barbara Jadach, Zofia Mielcarek, Tomasz Osmałek
Collagen (CLG) belongs to the family of fibrillar proteins and is composed of left-handed α polypeptide chains, which, twisting around themselves and their axis, form a right-handed superhelix. In the chemical structure, it contains mainly proline, hydroxyproline, glycine, and hydroxylysine. It occurs naturally in the dermis in the form of fibers that provide the skin with proper density and elasticity. The review aimed to present the types of collagen protein, factors affecting its structure and its unusual role in the functioning of the human body...
March 4, 2024: Current Issues in Molecular Biology
https://read.qxmd.com/read/38534693/intrapulmonary-and-systemic-pharmacokinetics-of-colistin-following-nebulization-of-low-dose-colistimethate-sodium-in-patients-with-ventilator-associated-pneumonia-caused-by-carbapenem-resistant-acinetobacter-baumannii
#39
JOURNAL ARTICLE
Dong-Hwan Lee, Shin-Young Kim, Yong-Kyun Kim, So-Young Jung, Ji-Hoon Jang, Hang-Jea Jang, Jae-Ha Lee
Colistimethate sodium (CMS) nebulization is associated with reduced systemic toxicity compared to intravenous injection, with potentially enhanced clinical efficacy. This study aimed to assess the pharmacokinetic (PK) properties of colistin during low-dose CMS nebulization in patients with ventilator-associated pneumonia (VAP) caused by carbapenem-resistant Acinetobacter baumannii . A nonlinear mixed-effects modeling approach was applied to develop population PK models for colistin in both epithelial lining fluid (ELF) and plasma...
March 14, 2024: Antibiotics
https://read.qxmd.com/read/38534640/control-of-escherichia-coli-in-poultry-using-the-in-ovo-injection-technique
#40
REVIEW
Gabriel da Silva Oliveira, Concepta McManus, Vinícius Machado Dos Santos
Pathogens, such as Escherichia coli ( E . coli ), have been identified as significant causes of poultry mortality. Poultry can serve as potential sources of E . coli transmission, even when asymptomatic, posing a substantial threat to food safety and human health. The in ovo administration of antimicrobials is crucial for preventing and/or effectively combating acute and chronic infections caused by poultry pathogens. To achieve this goal, it is critical that antimicrobials are properly injected into embryonic fluids, such as the amnion, to reach target tissues and trigger robust antimicrobial responses...
February 22, 2024: Antibiotics
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