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https://www.readbyqxmd.com/read/29169195/wide-field-piecemeal-cold-snare-polypectomy-of-large-sessile-serrated-polyps-without-a-submucosal-injection-is-safe
#1
David J Tate, Halim Awadie, Farzan F Bahin, Lobke Desomer, Ralph Lee, Steven J Heitman, Kathleen Goodrick, Michael J Bourke
Background and study aims Large series suggest endoscopic mucosal resection is safe and effective for the removal of large (≥ 10 mm) sessile serrated polyps (SSPs), but it exposes the patient to the risks of electrocautery, including delayed bleeding. We examined the feasibility and safety of piecemeal cold snare polypectomy (pCSP) for the resection of large SSPs. Methods Sequential large SSPs (10 - 35 mm) without endoscopic evidence of dysplasia referred over 12 months to a tertiary endoscopy center were considered for pCSP...
November 23, 2017: Endoscopy
https://www.readbyqxmd.com/read/29169154/development-of-age-related-macular-degeneration-amd-in-the-fellow-eye-of-patients-with-amd-treated-by-treat-and-extend-intravitreal-therapy-with-aflibercept
#2
Kensuke Mimura, Hidetaka Matsumoto, Masahiro Morimoto, Hideo Akiyama
PURPOSE: To evaluate the development of neovascular age-related macular degeneration (nAMD) in the fellow eye in patients with unilateral nAMD treated by a treat-and-extend (TAE) regimen with intravitreal aflibercept injections. METHODS: We retrospectively studied 104 patients with treatment-naïve unilateral nAMD. We assessed best-corrected visual acuity (BCVA) and exudative changes in the treated eyes and development of nAMD in the fellow eye for 2 years. RESULTS: The subjects included 46 patients with typical AMD (tAMD), 44 with polypoidal choroidal vasculopathy (PCV), and 14 with retinal angiomatous proliferation (RAP)...
November 23, 2017: Ophthalmologica. Journal International D'ophtalmologie
https://www.readbyqxmd.com/read/29169149/prokaryotic-expression-and-anti-ibdv-activity-of-chicken-interleukin-18-and-interferon-%C3%AE
#3
Baifen Song, Xiaoting Li, Jinzhu Ma, Liquan Yu, Zhenyue Feng, Zhenhua Liu, Yudong Cui
Interferon-γ (IFN-γ), a cytokine produced by activated natural killer cells and T lymphocytes, is an important regulator of innate and adaptive immunity. Interleukin (IL)-18, also known as IFN-γ-inducing factor, is a cytokine that induces T and natural killer cells to produce IFN-γ. In this study, the chicken IL-18 (ChIL-18) and chicken IFN-γ (ChIFN-γ) genes were inserted into the pET28a prokaryotic expression vector, resulting in pET28a-IL-18 and pET28a-IFN-γ, respectively. These plasmids were transformed into Escherichia coli strain BL21, and the ChIL-18 and ChIFN-γ proteins were expressed and purified...
November 24, 2017: Cytogenetic and Genome Research
https://www.readbyqxmd.com/read/29169035/do-law-enforcement-interactions-reduce-the-initiation-of-injection-drug-use-an-investigation-in-three-north-american-settings
#4
J S Melo, R S Garfein, K Hayashi, M J Milloy, K DeBeck, S Sun, S Jain, S A Strathdee, D Werb
BACKGROUND: The prevention of drug injecting is often cited as a justification for the deployment of law enforcement and for the continuation of drug criminalization policies. We sought to characterize the impact of law enforcement interactions on the risk that people who inject drugs (PWID) report assisting others with injection initiation in three North American countries. METHODS: Cross-sectional data from PWID participating in cohort studies in three cities (San Diego, USA; Tijuana, Mexico; Vancouver, Canada) were pooled (August 2014-December 2016)...
November 16, 2017: Drug and Alcohol Dependence
https://www.readbyqxmd.com/read/29168906/recurrent-mycobacterium-fortuitum-insulin-injection-site-abscesses
#5
Velda Xy Han, Kah-Yin Loke, Si-Min Chan
No abstract text is available yet for this article.
November 23, 2017: Journal of Paediatrics and Child Health
https://www.readbyqxmd.com/read/29168791/administration-of-protocatechuic-acid-reduces-traumatic-brain-injury-induced-neuronal-death
#6
Sang Hwon Lee, Bo Young Choi, Song Hee Lee, A Ra Kho, Jeong Hyun Jeong, Dae Ki Hong, Sang Won Suh
Protocatechuic acid (PCA) was first purified from green tea and has shown numerous biological activities, including anti-apoptotic, anti-inflammatory, and anti-atherosclerotic effects. The effect of PCA on traumatic brain injury (TBI)-induced neuronal death has not previously been evaluated. TBI is defined as damage to the brain resulting from external mechanical force, such as rapid acceleration or deceleration, impact, blast waves, or penetration by a projectile. TBI causes neuronal death in the hippocampus and cerebral cortex...
November 23, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29168702/the-flocculation-mechanism-and-treatment-of-oily-wastewater-by-flocculation
#7
Zhenchao Zhang
In the present study, the performance of compound flocculants composed of different concentrations of polyaluminum chloride (PAC) and cationic polyacrylamide (CPAM), the influencing mechanism of the flocculation process and the effects of temperature, settling time, and speed and time of stirring were investigated. The results show that the poor water quality with high concentrations of oil, suspended solids (SS) and polymer greatly increases the oily wastewater emulsion stability and the difficulty of the flocculation treatment process...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29168659/hydrogel-spacers-in-prostate-radiotherapy-a-promising-approach-to-decrease-rectal-toxicity
#8
Ranjani Padmanabhan, Michael Pinkawa, Daniel Y Song
High-dose radiation is a well-established method of treatment for prostate cancer. The main limiting structure for dose escalation is the rectum. The risk of rectal toxicity is related to dose received by the rectum. Several strategies for reducing dose to rectum have been explored; these include endorectal balloons as well as injection of rectal spacers like hydrogels. They create greater distance between rectal wall and prostate to confer a dosimetric advantage to the rectum. Early clinical studies with hydrogels have shown favorable outcomes...
November 23, 2017: Future Oncology
https://www.readbyqxmd.com/read/29168595/berberine-impairs-embryonic-development-in-vitro-and-in-vivo-through-oxidative-stress-mediated-apoptotic-processes
#9
Chien-Hsun Huang, Zi-Wei Huang, Feng-Ming Ho, Wen-Hsiung Chan
Berberine, an isoquinoline alkaloid isolated from several traditional Chinese herbal medicines, has been shown to suppress growth and induce apoptosis in some tumor cell lines. However, berberine has also been reported to attenuate H2 O2 -induced oxidative injury and apoptosis. The basis for these ambiguous effects of berberine-triggering or preventing apoptosis-has not been well characterized to date. In the current investigation, we examined whether berberine exerts cytotoxic effects on mouse embryos at the blastocyst stage and affects subsequent embryonic development in vitro and in vivo...
November 23, 2017: Environmental Toxicology
https://www.readbyqxmd.com/read/29168593/respiratory-regulation-by-steroids-in-newborn-rats-a-sex-specific-balance-between-allopregnanolone-and-progesterone-receptors
#10
Vincent Joseph, NagaPraveena Uppari, Hayet Kouchi, Celia De Bruyn, Ryma Boukari, Aida Bairam
We tested the hypothesis that the effects of progesterone on apnoea frequency in newborn rats are the result of a balance between its neuroactive metabolite allopregnanolone (GABAa receptor modulator) and progesterone receptors. We used male and female rats between 10 and 12 days of age and recorded respiratory and metabolic parameters (whole-body plethysmography), and assessed the frequency and duration of apnoeas under normoxia. We tested the effects of a single injection of progesterone (4 mg kg(-1) , i...
November 23, 2017: Experimental Physiology
https://www.readbyqxmd.com/read/29168543/lipid-lowering-therapy-with-pcsk9-inhibitors-in-the-management-of-cardiovascular-high-risk-patients-effectiveness-therapy-adherence-and-safety-in-a-real-world-cohort
#11
Michael Saborowski, Michael Dölle, Michael P Manns, Holger Leitolf, Steffen Zender
BACKGROUND: PCSK9-inhibitors have shown great potential in efficient lipid lowering to achieve low-density lipoprotein-cholesterol (LDL-C) treatment goals. The aim of the study was too describe the clinical use of PCSK9-inhibitors and to investigate therapy adherence and safety outside of clinical trials. METHODS: 38 patients were treated with PSCK9-inhibitors. Patients were eligible for this therapy based on their individual cardiovascular risk and when all other available lipid-lowering regimen had failed...
November 23, 2017: Cardiology Journal
https://www.readbyqxmd.com/read/29168520/vertical-charge-transport-through-transition-metal-dichalcogenides-a-quantitative-analysis
#12
Yuqi Zhu, Ruiping Zhou, Feng Zhang, Joerg Appenzeller
Based on the careful design of two-terminal devices from multi-layer transition metal dichalcogenides (TMDs) such as MoS2 and WSe2, truly vertical transport has been experimentally evaluated and theoretically analyzed. By exploring, the electric field and temperature dependence of in total 28 TMD devices of various thicknesses, a model that describes vertical transport as Fowler Nordheim mediated at high electric fields and thermal injection dominated at low fields has been developed. Our approach is similar to the description chosen to capture gate leakage current levels through amorphous materials such as SiO2...
November 23, 2017: Nanoscale
https://www.readbyqxmd.com/read/29168317/hepatitis-c-virus-prevalence-and-associated-risk-factors-among-indigenous-australians-who-inject-drugs
#13
Michael Doyle, Lisa Maher, Simon Graham, Handan Wand, Jenny Iversen
OBJECTIVE: To examine factors associated with hepatitis C virus (HCV) infection among a national sample of Indigenous and non-Indigenous people who inject drugs (PWID) in Australia. METHODS: Respondents were recruited from Australia's Needle Syringe Program Survey; an annual bio-behavioural surveillance project that monitors HCV antibody prevalence among PWID. Data from 2006-2015 were de-duplicated to retain only one record where individuals participated in >1 survey round...
November 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29168304/aboriginal-children-and-penicillin-injections-for-rheumatic-fever-how-much-of-a-problem-is-injection-pain
#14
Alice G Mitchell, Suzanne Belton, Vanessa Johnston, Clancy Read, Clair Scrine, Anna P Ralph
OBJECTIVE: To explore young Aboriginal people's and clinicians' experiences of injection pain for the 10 years of penicillin injections children are prescribed to prevent rheumatic fever recurrences. METHODS: Aboriginal children on the penicillin regimen and clinicians were purposively recruited from four remote sites in Australia. Semi-structured interviews and participant observations were conducted. Views were synthesised and thematically analysed. RESULTS: A total of 29 Aboriginal children and 59 clinicians were interviewed...
November 22, 2017: Australian and New Zealand Journal of Public Health
https://www.readbyqxmd.com/read/29168263/incidence-and-predictors-of-mental-health-disorder-diagnoses-among-people-who-inject-drugs-in-a-canadian-setting
#15
Hudson Reddon, Tyler Pettes, Evan Wood, Ekaterina Nosova, Michael-John Milloy, Thomas Kerr, Kanna Hayashi
INTRODUCTION AND AIMS: Limited attention has been given to the predictors of mental health diagnoses among people who inject drugs (PWID) in community settings. Therefore, we sought to longitudinally examine the prevalence, incidence and predictors of mental disorder diagnosis among a community-recruited cohort of PWID. DESIGN AND METHODS: Data were derived from two prospective cohort studies of PWID (VIDUS and ACCESS) in Vancouver, Canada between December 2005 and May 2015...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29168262/cross-border-migration-and-initiation-of-others-into-drug-injecting-in-tijuana-mexico
#16
Claudia Rafful, Jason Melo, María Elena Medina-Mora, Gudelia Rangel, Xiaoying Sun, Sonia Jain, Dan Werb
INTRODUCTION AND AIMS: Efforts to prevent injection drug use (IDU) are increasingly focusing on the role that people who inject drugs (PWID) play in facilitating the entry of others into this behaviour. This is particularly relevant in settings experiencing high levels of IDU, such as Mexico's northern border region, where cross-border migration, particularly through forced deportation, has been found to increase a range of health and social harms related to injecting. DESIGN AND METHODS: PWID enrolled in a prospective cohort study in Tijuana, Mexico, since 2011 were interviewed semi-annually, which solicited responses on their experiences initiating others into injecting...
November 22, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/29168261/-impact-of-drug-reimbursement-policies-on-prescribing-a-case-study-of-a-newly-marketed-long-acting-injectable-antipsychotics-among-relapsed-schizophrenia-patients
#17
John W Jackson, Lisa Fulchino, James Rogers, Helen Mogun, Jennifer Polinski, David C Henderson, Sebastian Schneeweiss, Michael A Fischer
OBJECTIVE: To quantify and explain variation in use of long-acting injectable antipsychotics (LAIs) in the United States, and understand the relationship between patient characteristics, drug reimbursement policies, and LAI prescribing after relapse. METHODS: A cohort of recently relapsed patients with schizophrenia ages 18 to 64, identified immediately after discharge from a related inpatient hospitalization, partial hospitalization, or emergency room visit, drawn from 2004 to 2006 Medicaid claims, and followed for 90 days until LAI initiation...
November 23, 2017: Pharmacoepidemiology and Drug Safety
https://www.readbyqxmd.com/read/29168236/a-prospective-multicenter-phase-ii-study-of-intrabone-marrow-transplantation-of-unwashed-cord-blood-using-reduced-intensity-conditioning
#18
Masaya Okada, Taizo Tasaka, Kazuhiro Ikegame, Nobuyuki Aotsuka, Takeshi Kobayashi, Yuho Najima, Yoshiko Matsuhashi, Hideho Wada, Hirotoshi Tokunaga, Shinichi Masuda, Yoshikazu Utsu, Satoshi Yoshihara, Katsuji Kaida, Takashi Daimon, Hiroyasu Ogawa
Cord blood transplantation (CBT) is associated with delayed hematopoietic recovery and graft failure. To overcome these problems, we conducted a prospective, multicenter phase II study of intrabone marrow transplantation in which patients received reduced-intensity conditioning without anti-thymocyte globulin. The primary endpoint was the probability of full donor engraftment. Forty patients with hematologic malignancies were enrolled. CB cells were injected without washing into 4 iliac bone sites (2 at each hemipelvis), at which approximately 6 mL of CB was administered at one site with local anesthesia...
November 23, 2017: European Journal of Haematology
https://www.readbyqxmd.com/read/29168214/transdermal-light-neuromodulation-optogenetics-in-the-murine-urinary-tract
#19
Shannon L Wallace, Robert S Kelley, Shailja Mehta, Giannina Descalzi, John A Fantl, Charles Ascher-Walsh
BACKGROUND: Optogenetics is a biologic technique that uses light to control living neurons, which have been genetically modified to express light-sensitive ion-channels. OBJECTIVES: Using an adenovirus to modify the sciatic nerves of mice, we aim to demonstrate peripheral neuromodulation of bladder pain using transdermal light. STUDY DESIGN: This pilot study is divided into: A) Confirmation and Application and B) Behavioral Step. A) Six mice were injected with AAV6-hSyn-ChR2(H134R)-eYFP virus into their sciatic nerves...
November 23, 2017: Neurourology and Urodynamics
https://www.readbyqxmd.com/read/29168180/cxcr2-is-critical-for-bacterial-control-and-development-of-joint-damage-and-pain-in-staphylococcus-aureus-induced-septic-arthritis-in-mouse
#20
Daiane Boff, Vivian L S Oliveira, Celso M Queiroz Junior, Tarcília A Silva, Marcelo Allegretti, Waldiceu A Verri, Paul Proost, Mauro M Teixeira, Flavio A Amaral
Staphylococcus aureus is the main pathogen associated with septic arthritis. Upon infection, neutrophils are quickly recruited to the joint by different chemoattractants, especially CXCR1/2 binding chemokines. Although their excessive accumulation is associated with intense pain and permanent articular damage, neutrophils have an important function in controlling bacterial burden. This work aimed to study the role of CXCR2 in the control of infection, hypernociception and tissue damage in S. aureus-induced septic arthritis in mice...
November 22, 2017: European Journal of Immunology
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