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https://www.readbyqxmd.com/read/28810156/more-inflammation-but-less-brain-derived-neurotrophic-factor-in-antisocial-personality-disorder
#1
Tzu-Yun Wang, Sheng-Yu Lee, Ming-Chuan Hu, Shiou-Lan Chen, Yun-Hsuan Chang, Chun-Hsien Chu, Shih-Hsien Lin, Chia-Ling Li, Liang-Jen Wang, Po See Chen, Shih-Heng Chen, San-Yuan Huang, Nian-Sheng Tzeng, I Hui Lee, Kao Chin Chen, Yen Kuang Yang, Jau-Shyong Hong, Ru-Band Lu
Antisocial personality disorder (ASPD) is highly comorbid with substance use disorders (SUDs). We hypothesize that chronic neuroinflammation and the loss of neurotrophic factors prompts the pathogenesis of both disorders. We used ELISA to measure plasma levels of proinflammatory (tumor necrosis factor-α [TNF-α], C-reactive protein [CRP]) and anti-inflammatory factors (transforming growth factor-β1 [TGF-β1] and interleukin-10 [IL-10]), and brain-derived neurotrophic factor (BDNF) in male patients with ASPD (n=74), SUDs (n=168), ASPD comorbid with SUDs (ASPD+SUDs) (n=438), and Healthy Controls (HCs) (n=81)...
August 5, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28799678/processing-and-characterization-of-canine-mixed-mammary-tumor-using-transmission-electron-microscopy
#2
Beltrán Audrey, Debut Alexis, Vaca Andrea, Ortiz Julio, Proaño-Pérez Freddy
Canine mammary gland tumors represent the second most frequent type of neoplasm in dogs, being an important problem within veterinary medical field. Canine mixed mammary tumors are the most common; the use of a transmission electron microscope (TEM) can contribute as a tool in its diagnosis by determining the characteristics of cellular components from numerous neoplasms. The aim of this study was to characterize cytologically canine mammary mixed tumor by the use of the TEM. A biopsy collected from an 11 years old bitch Shih-Tzu and analyzed by histopathology was used for ultrastructural analysis...
August 11, 2017: Microscopy Research and Technique
https://www.readbyqxmd.com/read/28776921/retinal-detachment-and-glaucoma-in-the-boston-terrier-and-shih-tzu-following-phacoemulsification-135-patients-2000-2014
#3
Braidee C Foote, Samantha L Pederson, Anja Welihozkiy, Jessica M Stine, Susan M Carastro, Stacy E Andrew, Tammy M Michau
OBJECTIVES: To report the cumulative incidence of retinal detachment (RD) and glaucoma following phacoemulsification in Boston Terriers and Shih Tzu in the southeastern United States over a 14-year period and investigate the potential predisposing risk factors. METHODS: Medical records of 83 Shih Tzu and 52 Boston Terriers that underwent phacoemulsification between 2000 and 2014, with or without intraocular lens placement, were reviewed. For a comparison population, phacoemulsification data from 45 Labrador Retrievers, 73 Schnauzers, and 159 Bichon Frises were evaluated...
August 3, 2017: Veterinary Ophthalmology
https://www.readbyqxmd.com/read/28735662/68ga-dotatoc-and-18f-fdg-pet-ct-for-identifying-the-primary-lesions-of-suspected-and-metastatic-neuroendocrine-tumors-a%C3%A2-prospective-study-in-taiwan
#4
Shih-Hsin Chen, Yu-Chuan Chang, Tsann-Long Hwang, Jen-Shi Chen, Wen-Chi Chou, Chia-Hsun Hsieh, Ta-Sen Yeh, Jun-Te Hsu, Chun-Nan Yeh, Jeng-Hwei Tseng, Tse-Ching Chen, Tzu-Chen Yen
BACKGROUND/PURPOSE: To investigate the diagnostic accuracy of 68Ga-DOTATOC and 18F-FDG PET/CT to identify the primary foci in Taiwanese patients with clinically suspected neuroendocrine tumors (NET) and NET of unknown primary site. METHODS: Patients with clinically suspected NET and NET of unknown primary site were eligible. All participants underwent a conventional workup (including CT, MR, endoscopic ultrasound), 68Ga-DOTATOC, and 18F-FDG PET/CT. The results of pathology and findings on clinical follow-up served as the gold standard...
July 20, 2017: Journal of the Formosan Medical Association, Taiwan Yi Zhi
https://www.readbyqxmd.com/read/28731681/first-n-borylated-emitters-displaying-highly-efficient-thermally-activated-delayed-fluorescence-and-high-performance-oleds
#5
Yi-Jyun Lien, Tzu-Chieh Lin, Chun-Chieh Yang, Yu-Cheng Chiang, Chih-Hao Chang, Shih-Hung Liu, Yi-Ting Chen, Gene-Hsiang Lee, Pi-Tai Chou, Chin-Wei Lu, Yun Chi
Despite the fast boom of thermally activated delayed fluorescence (TADF) emitters bearing borane-based acceptor, so far, no TADF emitter with a direct B-N linkage between N-donor and boryl acceptor has been reported. The latter should simplify the molecular architecture and hence facilitate the synthetic design and versatility. We report here the preparation and characterization of a new series of N-borylated compounds with functional acridine donor unit; namely: ACBM, PACBM, and SACBM. Spectroscopic studies were performed to explore their photophysical properties that exhibited prominent solvatochromism and thermally activated delayed fluorescence...
August 16, 2017: ACS Applied Materials & Interfaces
https://www.readbyqxmd.com/read/28726018/association-of-vagotomy-and-decreased-risk-of-subsequent-ischemic-stroke-in-complicated-peptic-ulcer-patients-an-asian-population-study
#6
Chu-Wen Fang, Chun-Hung Tseng, Shih-Chi Wu, William Tzu-Liang Chen, Chih-Hsin Muo
OBJECTIVES: The primary management of peptic ulcers is medical treatment. Persistent exacerbation of a peptic ulcer may lead to complications (perforation and/or bleeding). There has been a trend toward the use of a less invasive surgical simple suture, simple local suture or non-operative (endoscopic/angiography) hemostasis rather than acid-reducing vagotomy (i.e., vagus nerve severance) for treating complicated peptic ulcers. Other studies have shown the relationship between high vagus nerve activity and survival in cancer patients via reduced levels of inflammation, indicating the essential role of the vagus nerve...
July 19, 2017: World Journal of Surgery
https://www.readbyqxmd.com/read/28708079/comparison-of-erosion-behavior-and-particle-contamination-in-mass-production-cf%C3%A2-o%C3%A2-plasma-chambers-using-y%C3%A2-o%C3%A2-and-yf%C3%A2-protective-coatings
#7
Tzu-Ken Lin, Wei-Kai Wang, Shih-Yung Huang, Chi-Tsung Tasi, Dong-Sing Wuu
Yttrium fluoride (YF₃) and yttrium oxide (Y₂O₃) protective coatings prepared using an atmospheric plasma spraying technique were used to investigate the relationship between surface erosion behaviors and their nanoparticle generation under high-density plasma (10(12)-10(13) cm(-3)) etching. As examined by transmission electron microscopy, the Y₂O₃ and YF₃ coatings become oxyfluorinated after exposure to the plasma, wherein the yttrium oxyfluoride film formation was observed on the surface with a thickness of 5...
July 14, 2017: Nanomaterials
https://www.readbyqxmd.com/read/28701266/community-acquired-bloodstream-infections-caused-by-acinetobacter-baumannii-a%C3%A2-matched-case-control-study
#8
Chung-Ting Chen, Yung-Chih Wang, Shu-Chen Kuo, Fang-Huy Shih, Te-Li Chen, Chorng-Kuang How, Ya-Sung Yang, Yi-Tzu Lee
BACKGROUND: Acinetobacter baumannii is an important nosocomial pathogen worldwide. Its role in community-acquired infection remains controversial and has rarely been reported. METHODS: Patients with monobacterial bloodstream infections caused by genomic species identified A. baumannii, admitted to Taipei Veterans General Hospital between 1999 and 2010, were selected as cases. Controls were defined as patients acquiring infection in a healthcare setting and were matched for age and sex...
June 29, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28693925/a-ct-contrast-based-strain-specific-real-time-quantitative-pcr-system-for-lactobacilllus-paracasei-subsp-paracasei-ntu-101
#9
Chih-Hui Lin, Tsung-Wei Shih, Tzu-Ming Pan
BACKGROUND/PURPOSES: Routine cell number determination for specific Lactobacillus strain by cultivation requires at least 4-7 days. Thus rapid and specific cell number determine methods such as strain-specific quantitative PCR (qPCR) are valuable. However, qPCR method is vulnerable to difficult PCR target such as dimer/secondary structure forming sequence. METHODS: In this study, a two-component, "Ct contrast" approach was applied to strain-specific qPCR system following the development of Lactobacillus paracasei subsp...
June 28, 2017: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/28691927/ubiquitination-of-tumor-suppressor-pml-regulates-prometastatic-and-immunosuppressive-tumor-microenvironment
#10
Ya-Ting Wang, Jocelyn Chen, Chou-Wei Chang, Jayu Jen, Tzu-Yu Huang, Chun-Ming Chen, Roger Shen, Suh-Yuen Liang, I-Cheng Cheng, Shuenn-Chen Yang, Wu-Wei Lai, Kuang-Hung Cheng, Tao-Shih Hsieh, Ming-Zong Lai, Hung-Chi Cheng, Yi-Ching Wang, Ruey-Hwa Chen
The tumor microenvironment plays an important role in tumor growth and metastasis. However, the mechanism by which tumor cells regulate the cell and non-cell constituents of surrounding stroma remains incompletely understood. Promyelocytic leukemia (PML) is a pleiotropic tumor suppressor, but its role in tumor microenvironment regulation is poorly characterized. PML is frequently downregulated in many cancer types, including lung cancer. Here, we identify a PML ubiquitination pathway that is mediated by WD repeat 4-containing cullin-RING ubiquitin ligase 4 (CRL4WDR4)...
August 1, 2017: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/28686748/correction-hepatitis-c-virus-core-protein-down-regulates-p21waf1-cip1-and-inhibits-curcumin-induced-apoptosis-through-microrna-345-targeting-in-human-hepatoma-cells
#11
Tzu-Yue Shiu, Shih-Ming Huang, Yu-Lueng Shih, Heng-Cheng Chu, Wei-Kuo Chang, Tsai-Yuan Hsieh
[This corrects the article DOI: 10.1371/journal.pone.0061089.].
2017: PloS One
https://www.readbyqxmd.com/read/28678173/molecular-and-clinicopathological-differences-by-age-at-the-diagnosis-of-colorectal-cancer
#12
Chu-Cheng Chang, Pei-Ching Lin, Chun-Chi Lin, Yuan-Tzu Lan, Hung-Hsin Lin, Chien-Hsing Lin, Shung-Haur Yang, Wen-Yi Liang, Wei-Shone Chen, Jeng-Kai Jiang, Jen-Kou Lin, Shih-Ching Chang
We compared the clinicopathological and molecular profiles between different age groups of sporadic colorectal cancer (CRC) patients (age <50, 56-60, 60-70, 70-80, and >80); 1475 CRC patients were enrolled after excluding 30 individuals with Lynch syndrome. The mutation spectra for APC, TP53, KRAS, PIK3CA, FBXW7, BRAF, NRAS, HRAS, TGFbR, Akt1, and PTEN were analyzed using polymerase chain reaction (PCR), followed by MassArray and microsatellite (MSI-high) analysis by performing genotyping. Male patients (74...
July 5, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28674439/improving-biodiversity-assessment-via-unsupervised-separation-of-biological-sounds-from-long-duration-recordings
#13
Tzu-Hao Lin, Shih-Hua Fang, Yu Tsao
Investigating the dynamics of biodiversity via passive acoustic monitoring is a challenging task, owing to the difficulty of identifying different animal vocalizations. Several indices have been proposed to measure acoustic complexity and to predict biodiversity. Although these indices perform well under low-noise conditions, they may be biased when environmental and anthropogenic noises are involved. In this paper, we propose a periodicity coded non-negative matrix factorization (PC-NMF) for separating different sound sources from a spectrogram of long-term recordings...
July 3, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28670226/management-of-crohn-s-disease-in-taiwan-consensus-guideline-of-the-taiwan-society-of-inflammatory-bowel-disease
#14
REVIEW
Shu-Chen Wei, Ting-An Chang, Te-Hsin Chao, Jinn-Shiun Chen, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tien-Yu Huang, Tzu-Chi Hsu, Chun-Chi Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Chen Lin, Yen-Hsuan Ni, Ming-Jium Shieh, I-Lun Shih, Chia-Tung Shun, Yuk-Ming Tsang, Cheng-Yi Wang, Horng-Yuan Wang, Meng-Tzu Weng, Deng-Chyang Wu, Wen-Chieh Wu, Hsu-Heng Yen, Jau-Min Wong
Crohn's disease (CD) is a chronic relapsing and remitting inflammatory disease of the gastrointestinal tract. CD is rare in Taiwan and other Asian countries, but its prevalence and incidence have been steadily increasing. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of CD taking into account currently available evidence and the expert opinion of the committee. Thorough clinical, endoscopic, and histological assessments are required for accurate diagnosis of CD...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28670225/management-of-ulcerative-colitis-in-taiwan-consensus-guideline-of-the-taiwan-society-of-inflammatory-bowel-disease
#15
REVIEW
Shu-Chen Wei, Ting-An Chang, Te-Hsin Chao, Jinn-Shiun Chen, Jen-Wei Chou, Yenn-Hwei Chou, Chiao-Hsiung Chuang, Wen-Hung Hsu, Tien-Yu Huang, Tzu-Chi Hsu, Chun-Chi Lin, Hung-Hsin Lin, Jen-Kou Lin, Wei-Chen Lin, Yen-Hsuan Ni, Ming-Jium Shieh, I-Lun Shih, Chia-Tung Shun, Yuk-Ming Tsang, Cheng-Yi Wang, Horng-Yuan Wang, Meng-Tzu Weng, Deng-Chyang Wu, Wen-Chieh Wu, Hsu-Heng Yen, Jau-Min Wong
Ulcerative colitis (UC) is an inflammatory bowel disease characterized by chronic mucosal inflammation of the colon, and the prevalence and incidence of UC have been steadily increasing in Taiwan. A steering committee was established by the Taiwan Society of Inflammatory Bowel Disease to formulate statements on the diagnosis and management of UC taking into account currently available evidence and the expert opinion of the committee. Accurate diagnosis of UC requires thorough clinical, endoscopic, and histological assessment and careful exclusion of differential diagnoses, particularly infectious colitis...
July 2017: Intestinal Research
https://www.readbyqxmd.com/read/28630713/corneal-ulcerative-disease-in-dogs-under-primary-veterinary-care-in-england-epidemiology-and-clinical-management
#16
Dan G O'Neill, Monica M Lee, Dave C Brodbelt, David B Church, Rick F Sanchez
BACKGROUND: Corneal ulcerative disease (CUD) has the potential to adversely affect animal welfare by interfering with vision and causing pain. The study aimed to investigate for the first time the prevalence, breed-based risk factors and clinical management of CUD in the general population of dogs under primary veterinary care in England. RESULTS: Of 104,233 dogs attending 110 clinics participating within the VetCompass Programme from January 1(st) to December 31(st) 2013, there were 834 confirmed CUD cases (prevalence: 0...
2017: Canine Genetics and Epidemiology
https://www.readbyqxmd.com/read/28611246/inhibition-of-avian-influenza-a-virus-replication-in-human-cells-by-host-restriction-factor-tufm-is-correlated-with-autophagy
#17
Shu-Ming Kuo, Chi-Jene Chen, Shih-Cheng Chang, Tzu-Jou Liu, Yi-Hsiang Chen, Sheng-Yu Huang, Shin-Ru Shih
Avian influenza A viruses generally do not replicate efficiently in human cells, but substitution of glutamic acid (Glu, E) for lysine (Lys, K) at residue 627 of avian influenza virus polymerase basic protein 2 (PB2) can serve to overcome host restriction and facilitate human infectivity. Although PB2 residue 627 is regarded as a species-specific signature of influenza A viruses, host restriction factors associated with PB2627E have yet to be fully investigated. We conducted immunoprecipitation, followed by differential proteomic analysis, to identify proteins associating with PB2627K (human signature) and PB2627E (avian signature) of influenza A/WSN/1933(H1N1) virus, and the results indicated that Tu elongation factor, mitochondrial (TUFM), had a higher binding affinity for PB2627E than PB2627K in transfected human cells...
June 13, 2017: MBio
https://www.readbyqxmd.com/read/28610956/upregulation-of-microrna-137-expression-by-slug-promotes-tumor-invasion-and-metastasis-of-non-small-cell-lung-cancer-cells-through-suppression-of-tfap2c
#18
Tzu-Hua Chang, Meng-Feng Tsai, Chien-Hung Gow, Shang-Gin Wu, Yi-Nan Liu, Yih-Leong Chang, Sung-Liang Yu, Hsing-Chen Tsai, Shih-Wen Lin, Yen-Wei Chen, Po-Yen Kuo, Pan-Chyr Yang, Jin-Yuan Shih
The epithelial-mesenchymal transition (EMT) regulator, Slug, plays multifaceted roles in controlling lung cancer progression, but its downstream targets and mechanisms in promoting lung cancer progression have not been well defined. In particular, the miRNAs downstream of Slug in non-small cell lung cancer (NSCLC) remain undetermined. Here, we report that miR-137 is downstream of the EMT regulator, Slug, in lung cancer cells. Slug binds directly to the E-box of the miR-137 promoter and up-regulates its expression in lung cancer cells...
June 10, 2017: Cancer Letters
https://www.readbyqxmd.com/read/28590932/tdp-43-hdac6-axis-promoted-tumor-progression-and-regulated-nutrient-deprivation-induced-autophagy-in-glioblastoma
#19
Tzu-Wei Lin, Ming-Teh Chen, Liang-Tin Lin, Pin-I Huang, Wen-Liang Lo, Yi-Ping Yang, Kai-Hsi Lu, Yi-Wei Chen, Shih-Hwa Chiou, Cheng-Wen Wu
Glioblastoma Multiforme (GBM) is a lethal primary brain tumor with poor survival lifespan and dismal outcome. Surgical resection of GBM is greatly limited due to the biological significance of brain, giving rise to tumor relapse in GBM patients. Transactive response DNA binding protein-43 (TDP-43) is a DNA/RNA-binding protein known for causing neurodegenerative diseases through post-translational modification; but little is known about its involvement in cancer development. In this study, we found that nutrient deprivation in GBM cell lines elevated TDP-43 expression by a mechanism of evasion from ubiquitin-dependent proteolytic pathway, and subsequently activated the autophagy process...
May 18, 2017: Oncotarget
https://www.readbyqxmd.com/read/28588831/surgical-and-medical-treatment-of-ocular-disease-in-a-dog-with-ehlers-danlos-syndrome
#20
Søren N Rasch
Correctional surgery was performed on a 3-year-old intact male shih tzu presenting with Ehlers-Danlos syndrome, ocular disease, and skin fold dermatitis. A one-year follow-up showed that no further clinical corrections were needed. Therefore, surgery could be considered in some canine patients with Ehlers-Danlos syndrome.
June 2017: Clinical Case Reports
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