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Sheng-Han Tsai, Chien-An Liu, Kuo-Hung Huang, Yuan-Tzu Lan, Ming-Huang Chen, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Shih-Hwa Chiou, Muh-Hwa Yang, Yi-Ming Shyr, Wen-Liang Fang
Robot-assisted gastrectomy has been reported to be a safe alternative to both conventional laparoscopy and the open approach for treating early gastric carcinoma. Currently, there are a limited number of published reports on this technique in the literature. We assessed the current status of robotic and laparoscopic surgery in the treatment of gastric cancer and compared the operative outcomes, learning curves, and oncological outcome of the two approaches. Robotic gastrectomy offers benefits that include increased ease of performing D2 lymph node dissection and reduced blood loss compared with laparoscopic gastrectomy...
October 17, 2016: Pathology Oncology Research: POR
Ko Chang, Chaur-Dong Chen, Chien-Ming Shih, Tzu-Chi Lee, Ming-Tsang Wu, Deng-Chyang Wu, Yen-Hsu Chen, Chih-Hsing Hung, Meng-Chieh Wu, Chun-Chi Huang, Chien-Hung Lee, Chi-Kung Ho
In Kaohsiung, a metropolitan city in Taiwan at high risk of dengue epidemic, weather factors combined with an accidental petrochemical gas explosion (PGE) may affect mosquito‒human dynamics in 2014. Generalized estimating equations with lagged-time Poisson regression analyses were used to evaluate the effect of meteorological/mosquito parameters and PGE on dengue incidences (2000-2014) in Kaohsiung. Increased minimum temperatures rendered a 2- and 3-month lagging interactive effect on higher dengue risks, and higher rainfall exhibited a 1- and 2-month lagging interplay effect on lower risks (interaction, P ≤ 0...
October 13, 2016: Scientific Reports
Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu, Pey-Jium Chang
The switch between latency and the lytic cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) is controlled by the expression of virally encoded ORF50 protein. Thus far, the regulatory mechanism underlying the protein stability of ORF50 is unknown. Our earlier studies have demonstrated that a protein abundance regulatory signal (PARS) at the ORF50 C-terminal region modulates its protein abundance. The PARS region consists of PARS-I (aa 490-535) and PARS-II (aa 590-650), and mutations in either component result in abundant expression of ORF50...
October 2016: PLoS Pathogens
Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G Harroun, Jui-Yang Lai, Chih-Ching Huang
Angiogenesis is the process of formation of new blood vessels, which is essential to human biology, and also plays a crucial role in several pathologies such as tumor growth and metastasis, exudative age-related macular degeneration, and ischemia. Vascular endothelial growth factor (VEGF), in particular, VEGF-A165 is the most important pro-angiogenic factor for angiogenesis. Thus, blocking the interaction between VEGFs and their receptors is considered an effective anti-angiogenic strategy. We demonstrate for that first time that bovine serum albumin-capped graphene oxide (BSA-GO) exhibits high stability in physiological saline solution and possesses ultrastrong binding affinity towards VEGF-A165 [dissociation constant (Kd) ∼3 × 10(-12) M], which is at least five orders of magnitude stronger than that of high-abundant plasma proteins such as human serum albumin, fibrinogen, transferrin, and immunoglobulin G...
December 2016: Biomaterials
Chih-Yu Wu, Chao-Wei Huang, Zhen-Yu Guan, Jyun-Ting Wu, Shu-Yun Yeh, Chiao-Tzu Su, Chih-Hao Chang, Shih-Torng Ding, Hsien-Yeh Chen
The immobilization of biofunctional molecules to biomaterial surfaces has enabled and expanded the versatility of currently available biomaterials to a wider range of applications. In addition, immobilized biomolecules offer modified surfaces that allow the use of smaller amounts of potentially harmful substances or prevent overdose, while the exhibited biological functions remain persistently effective. Surface concentrations of chlorhexidine (CHX) (1.40±0.08×10(-9)mol·cm(-2)) and bone morphogenetic protein 2 (BMP-2) (1...
December 1, 2016: Materials Science & Engineering. C, Materials for Biological Applications
Wen-Jen Chen, Tzu-Yen Kuo, Feng-Chia Hsieh, Pi-Yu Chen, Chang-Sheng Wang, Yu-Ling Shih, Ying-Mi Lai, Je-Ruei Liu, Yu-Liang Yang, Ming-Che Shih
Rice bacterial blight caused by Xanthomonas oryzae pv. oryzae (Xoo) is one of the most destructive rice diseases worldwide. Therefore, in addition to breeding disease-resistant rice cultivars, it is desirable to develop effective biocontrol agents against Xoo. Here, we report that a soil bacterium Pseudomonas taiwanensis displayed strong antagonistic activity against Xoo. Using matrix-assisted laser desorption/ionization imaging mass spectrometry, we identified an iron chelator, pyoverdine, secreted by P. taiwanensis that could inhibit the growth of Xoo...
2016: Scientific Reports
Hsueh-Tzu Shih, Wei-Yu Chen, Kwei-Yan Liu, Zong-Siou Shih, Yi-Jyun Chen, Paul-Chen Hsieh, Kuan-Lin Kuo, Kuo-How Huang, Pang-Hung Hsu, Ya-Wen Liu, Shih-Peng Chan, Hsiu-Hsiang Lee, Yu-Chen Tsai, June-Tai Wu
To maintain a particular cell fate, a unique set of genes should be expressed while another set is repressed. One way to repress gene expression is through Polycomb group (PcG) proteins that compact chromatin into a silent configuration. In addition to cell fate maintenance, PcG proteins also maintain normal cell physiology, for example cell cycle. In the absence of PcG, ectopic activation of the PcG-repressed genes leads to developmental defects and malignant tumors. Little is known about the molecular nature of ectopic gene expression; especially what differentiates expression of a given gene in the orthotopic tissue (orthotopic expression) and the ectopic expression of the same gene due to PcG mutations...
September 2016: PLoS Genetics
Kao-Shang Shih, Pei-Wei Weng, Shang-Chih Lin, Yi-Tzu Chen, Cheng-Kung Cheng, Chian-Her Lee
Experimental and numerical methods have been extensively used to simulate the lumbar kinematics and mechanics. One of the basic parameters is the lumbar loads. In the literature, both concentrated and distributed loads have been assumed to simulate the in vivo lumbar loads. However, the inconsistent loads between those studies exist and make the comparison of their results controversial. Using finite-element method, this study aimed to numerically compare the effects of the concentrated, follower, and muscular loads on the lumbar biomechanics during flexion...
October 2016: Computer Methods and Programs in Biomedicine
Chao-Wei Huang, Tzu-Wen Hong, Ying-Jing Wang, Ko-Chien Chen, Ju-Chun Pei, Tai-Yuan Chuang, Wen-Sung Lai, Sheng-Hong Tsai, Richard Chu, Wei-Cheng Chen, Lee-Yan Sheen, Satoru Takahashi, Shih-Torng Ding, Tang-Long Shen
BACKGROUND: A newly defined Cordyceps species, Ophiocordyceps formosana (O. formosana) has been implicated in multitudinous bioactivities, including lowering glucose and cholesterol levels and modulating the immune system. However, few literatures demonstrate sufficient evidence to support these proposed functions. Although the use of Cordyceps spp. has been previously addressed to improve insulin insensitivity and improve the detrimental symptoms of depression; its mechanistic nature remains unsettled...
2016: BMC Complementary and Alternative Medicine
Chun-Ru Hsu, Chun-Hsing Liao, Tzu-Lung Lin, Han-Ru Yang, Feng-Ling Yang, Pei-Fang Hsieh, Shih-Hsiung Wu, Jin-Town Wang
Klebsiella pneumoniae can cause community-acquired pyogenic liver abscess (PLA). Capsular polysaccharide (CPS) is important for its virulence. Among 79 capsular (K) types discovered thus far, K57 is often associated with PLA. Here, we report the identification of a K57 variant. Cps gene locus sequencing revealed differences between the K57 reference strain 4425/51 (Ref-K57) and a variant, the PLA isolate A1142. While Ref-K57 cps contained orf13 encoding a putative acetyltransferase, the insertion of a putative transposase-encoding gene at this position was detected in A1142...
2016: Scientific Reports
Chiao-Yun Lin, Angel Chao, Tzu-Hao Wang, Li-Yu Lee, Lan-Yan Yang, Chia-Lung Tsai, Hsin-Shih Wang, Chyong-Huey Lai
Endometrial cancers expressing estrogen and progesterone receptors respond to hormonal therapy. The disappearance of steroid hormone receptor expression is common in patients with recurrent disease, ultimately hampering the clinical utility of hormonal therapy. Here, we demonstrate for the first time that nucleophosmin (NPM1/B23) suppression can restore the expression of estrogen receptor α (ESR1/ERα) in endometrial cancer cells. Mechanistically, B23 and activator protein-2γ (TFAP2C/AP2γ) form a complex that acts as a transcriptional repressor of ERα...
August 4, 2016: Oncotarget
Yung-Yueh Su, Shih-Shin Chen, Chia-Hsun Hsieh, Chun-Ta Liao, Chien-Yu Lin, Chung-Jan Kang, Tzu-Chen Yen
We sought to investigate the clinical utility of F-18 fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT) in Taiwanese patients with cancer of unknown primary site (CUP) and cervical nodal metastases. We also aimed to study the impact of F-18 FDG PET/CT on clinical treatment priority in this patient group. Between September 2006 and May 2014, patients with CUP and cervical nodal metastases who underwent F-18 FDG PET/CT imaging study were retrospectively identified. The clinicopathological risk factors and PET parameters were analyzed in relation to 2-year overall survival (OS) rates using univariate and multivariate analyses...
August 2016: Kaohsiung Journal of Medical Sciences
Chih-Hung Lai, Tzu-Wei Tseng, Yu-Lan Jou, Tse-Min Lu, Wen-Lieng Lee, Shih-Hsien Sung
No abstract text is available yet for this article.
November 1, 2016: International Journal of Cardiology
Hajjaj H M Abdu-Allah, Shih-Ting Huang, Tzu Ting Chang, Chia-Ling Chen, Han-Chung Wu, Wen-Shan Li
Building on the initial successful optimization of a novel series of tetraindoles, a second generation of the compounds with changes in the core phenyl ring was synthesized to improve anticancer properties. 17 new compounds with different rigidity, planarity, symmetry and degree of conjugation of their core structures to 5-hydroxyindole units were synthesized. All the compounds were fully characterized and tested against breast cancer cell line (MDA-MB-231). The results revealed that the core structure is required for activity and it should be aromatic, rigid, planar, symmetrical and conjugated for optimal activity...
September 15, 2016: Bioorganic & Medicinal Chemistry Letters
Angel Chao, Ren-Chin Wu, Shih-Ming Jung, Yun-Shien Lee, Shu-Jen Chen, Yen-Lung Lu, Chia-Lung Tsai, Chiao-Yun Lin, Yun-Hsin Tang, Ming-Yu Chen, Huei-Jean Huang, Hung-Hsueh Chou, Kuan-Gen Huang, Ting-Chang Chang, Tzu-Hao Wang, Chyong-Huey Lai
OBJECTIVES: Synchronous endometrial and ovarian carcinomas (SEOCs) present gynecologic oncologists with a challenging diagnostic puzzle: discriminating between double primary cancers and single primary cancer with metastasis. We aimed to determine the clonal relationship between simultaneously diagnosed endometrial and ovarian carcinomas. METHODS: Fourteen pairs of SEOCs of endometrioid type and two pairs of SEOCs with disparate histologic types (control for dual primary tumors) were subjected to massively parallel sequencing (MPS) and molecular inversion probe microarrays...
October 2016: Gynecologic Oncology
Shu-Li Wang, Lan-Fang Kung, Tzu-Hui Chen, Shih-Ming Hsiao, Pei-Ni Hsiao, Chii-Jun Chiou
BACKGROUND: As the prevalence of chronic kidney disease (CKD) increases, it is important to understand the self-care behavior of CKD patients. OBJECTIVES: To construct a CKD self-care scale and evaluate its metric properties. METHODS: Through literature review and clinical experience, question items were constructed and validated using item analysis. Factors analysis was used to validate the reliability and validity of the resultant questionnaire in a cross-sectional study...
August 2016: Hu Li za Zhi the Journal of Nursing
Yuan-Yun Tseng, Yin-Chen Huang, Tao-Chieh Yang, Shun-Tai Yang, Shou-Cheng Liu, Tzu-Min Chang, Yi-Chuan Kau, Shih-Jung Liu
Glioblastoma multiforme has a poor prognosis and is highly chemoresistant. In this study, we implanted biodegradable 1,3-bis[2-chloroethyl]-1-nitroso-urea-, irinotecan-, and cisplatin-eluting poly[(d,l)-lactide-co-glycolide] (BIC/PLGA) and virgin nanofibrous membranes on the brain surface of C6 glioma-bearing rats in concurrent and virgin groups, respectively. The concentrations of all applied drugs were significantly higher in the brain than in the blood for more than 8 weeks in all studied rats. Tumor growth was more rapid in the vehicle-treated group, and tumor volumes were significantly higher in the vehicle-treated group...
2016: Scientific Reports
Lucien V Vallone, Andrew M Enders, Hussni O Mohammed, Eric C Ledbetter
OBJECTIVE: To characterize canine superficial corneal pigment (SCP) in brachycephalic dogs using in vivo confocal microscopy (IVCM). ANIMALS STUDIED: Fifty-seven client-owned brachycephalic dogs from breeds predisposed to SCP (i.e., Boston Terrier, Lhasa Apso, Pekingese, Pug, and Shih Tzu). PROCEDURES: Complete ocular examination, including slit-lamp biomicroscopy, was used to determine presence or absence of SCP, and IVCM examinations were then performed...
July 29, 2016: Veterinary Ophthalmology
Chung-Pei Lee, Guan-Ting Liu, Hsiu-Ni Kung, Po-Ting Liu, Yen-Tzu Liao, Lu-Ping Chow, Ling-Shih Chang, Yu-Hsin Chang, Chou-Wei Chang, Wen-Chi Shu, Annie Angers, Antonella Farina, Su-Fang Lin, Ching-Hwa Tsai, Fadila Bouamr, Mei-Ru Chen
UNLABELLED: The cellular endosomal sorting complex required for transport (ESCRT) was recently found to mediate important morphogenesis processes at the nuclear envelope (NE). We previously showed that the Epstein-Barr virus (EBV) BFRF1 protein recruits the ESCRT-associated protein Alix to modulate NE structure and promote EBV nuclear egress. Here, we uncover new cellular factors and mechanisms involved in this process. BFRF1-induced NE vesicles are similar to those observed following EBV reactivation...
October 15, 2016: Journal of Virology
Yu-Tzu Chang, Jing-Shiang Hwang, Shih-Yuan Hung, Min-Sung Tsai, Jia-Ling Wu, Junne-Ming Sung, Jung-Der Wang
Although treatment for the dialysis population is resource intensive, a cost-effectiveness analysis comparing hemodialysis (HD) and peritoneal dialysis (PD) by matched pairs is still lacking. After matching for clinical characteristics and propensity scores, we identified 4,285 pairs of incident HD and PD patients from a Taiwanese national cohort during 1998-2010. Survival and healthcare expenditure were calculated by data of 14-year follow-up and subsequently extrapolated to lifetime estimates under the assumption of constant excess hazard...
2016: Scientific Reports
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