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https://www.readbyqxmd.com/read/29777899/congenital-dyshormonogenic-hypothyroidism-with-goiter-caused-by-a-sodium-iodide-symporter-slc5a5-mutation-in-a-family-of-shih-tzu-dogs
#1
E A Soler Arias, V A Castillo, J D Garcia, J C Fyfe
An iodide transport defect (ITD) in the thyroid gland was determined to cause congenital dyshormonogenic hypothyroidism with goiter (CDHG) in 2 members of a family of Shih-Tzu dogs. Strikingly, both dogs were also diagnosed with dilated cardiomyopathy at 24 and 1.5 mo of age. The only sign of hypothyroidism was a moderate growth delay in the adult dog. The ITD was recognized by the absence of uptake of technetium-99m in the salivary glands (sg) and goiter observed by scintigraphy. In the same scan, radiopharmaceutical uptake was found in the anterior mediastinum of both dogs and in the right axillary lymph node in the oldest dog...
April 24, 2018: Domestic Animal Endocrinology
https://www.readbyqxmd.com/read/29769657/correction-to-aryl-hydrocarbon-receptor-signaling-promotes-ormdl3-dependent-generation-of-sphingosine-1-phosphate-by-inhibiting-sphingosine-1-phosphate-lyase
#2
Hsueh-Chun Wang, Tzu-Hsuan Wong, Li-Ting Wang, Hsiang-Han Su, Hsiu-Yueh Yu, Ai-Hsuan Wu, Yu-Chun Lin, Hua-Ling Chen, Jau-Ling Suen, Shih-Hsien Hsu, Li-Chen Chen, Yufeng Zhou, Shau-Ku Huang
In this article, published online 23 March 2018, the affiliation 10 of Zhou Y was incorrect. The affiliation should be "Children's Hospital and Institute of Biomedical Sciences, Fudan University. Key Laboratory of Neonatal Disease, Ministry of Health, 201102, Shanghai, China." The authors regret the errors.
May 16, 2018: Cellular & Molecular Immunology
https://www.readbyqxmd.com/read/29748783/correction-to-soluble-delta-like-1-homolog-dlk1-stimulates-angiogenesis-through-notch1-akt-enos-signaling-in-endothelial-cells
#3
Chao-Cheng Huang, Hsiao-Mei Kuo, Pei-Chang Wu, Shih-Hsuan Cheng, Tzu-Ting Chang, Yi-Chen Chang, Mei-Lang Kung, Deng-Chyang Wu, Jiin-Haur Chuang, Ming-Hong Tai
In the original publication of the article, there is an error in one of the citations in the Discussion section.
May 10, 2018: Angiogenesis
https://www.readbyqxmd.com/read/29740176/biofilm-formation-is-not-associated-with-worse-outcome-in-acinetobacter-baumannii-bacteraemic-pneumonia
#4
Yung-Chih Wang, Tzu-Wen Huang, Ya-Sung Yang, Shu-Chen Kuo, Chung-Ting Chen, Chang-Pan Liu, Yuag-Meng Liu, Te-Li Chen, Feng-Yee Chang, Shih-Hsiung Wu, Chorng-Kuang How, Yi-Tzu Lee
The effect of biofilm formation on bacteraemic pneumonia caused by A. baumannii is unknown. We conducted a 4-year multi-center retrospective study to analyze 71 and 202 patients with A. baumannii bacteraemic pneumonia caused by biofilm-forming and non-biofilm-forming isolates, respectively. The clinical features and outcomes of patients were investigated. Biofilm formation was determined by a microtitre plate assay. The antimicrobial susceptibilities of biofilm-associated cells were assessed using the minimum biofilm eradication concentration (MBEC) assay...
May 8, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29734165/long-term-moderate-exercise-rescues-age-related-decline-in-hippocampal-neuronal-complexity-and-memory
#5
Sheng-Feng Tsai, Nai-Wen Ku, Tzu-Feng Wang, Yan-Hsiang Yang, Yao-Hsiang Shih, Shih-Ying Wu, Chu-Wan Lee, Megan Yu, Ting-Ting Yang, Yu-Min Kuo
BACKGROUND: Aging impairs hippocampal neuroplasticity and hippocampus-related learning and memory. In contrast, exercise training is known to improve hippocampal neuronal function. However, whether exercise is capable of restoring memory function in old animals is less clear. OBJECTIVE: Here, we investigated the effects of exercise on the hippocampal neuroplasticity and memory functions during aging. METHODS: Young (3 months), middle-aged (9-12 months), and old (18 months) mice underwent moderate-intensity treadmill running training for 6 weeks, and their hippocampus-related learning and memory, and the plasticity of their CA1 neurons was evaluated...
May 7, 2018: Gerontology
https://www.readbyqxmd.com/read/29731384/a-multicenter-study-on-clinical-characteristics-of-acinetobacter-bacteremia-in-patients-with-liver-cirrhosis
#6
Chang-Pan Liu, Tsung-Ta Chiang, Yuag-Meng Liu, Shu-Chen Kuo, Ya-Sung Yang, Yi-Tzu Lee, Te-Li Chen, Shou-Chuan Shih
BACKGROUND: Clinical characteristics and risk factors for mortality of Acinetobacter bacteremia in cirrhotic patients have not been investigated. METHODS: Acinetobacter bacteremia cases from four medical centers were collected from 2009 to 2014, to compare between patients with and without liver cirrhosis. Risk factors for mortality of Acinetobacter bacteremia among cirrhotic patients were identified using multivariate logistic regression. RESULTS: Among the patients with Acinetobacter bacteremia, 72 had liver cirrhosis and 816 had not...
April 25, 2018: Journal of Microbiology, Immunology, and Infection, Wei Mian Yu Gan Ran za Zhi
https://www.readbyqxmd.com/read/29731187/corrigendum-to-inhibition-of-protein-phosphatase-5-suppresses-non-small-cell-lung-cancer-through-amp-activated-kinase-activation-lung-cancer-112-october-2017-81-89
#7
Feng-Shu Hsieh, Man-Hsin Hung, Cheng-Yi Wang, Yen-Lin Chen, Yung-Jen Hsiao, Ming-Hsien Tsai, Jia-Rong Li, Li-Ju Chen, Chih-Ting Shih, Tzu-I Chao, Kuen-Feng Chen
No abstract text is available yet for this article.
May 3, 2018: Lung Cancer: Journal of the International Association for the Study of Lung Cancer
https://www.readbyqxmd.com/read/29725737/genomic-scar-signatures-associated-with-homologous-recombination-deficiency-predict-adverse-clinical-outcomes-in-patients-with-ovarian-clear-cell-carcinoma
#8
Angel Chao, Chyong-Huey Lai, Tzu-Hao Wang, Shih-Ming Jung, Yun-Shien Lee, Wei-Yang Chang, Lan-Yang Yang, Fei-Chun Ku, Huei-Jean Huang, An-Shine Chao, Chin-Jung Wang, Ting-Chang Chang, Ren-Chin Wu
We investigated whether genomic scar signatures associated with homologous recombination deficiency (HRD), which include telomeric allelic imbalance (TAI), large-scale transition (LST), and loss of heterozygosity (LOH), can predict clinical outcomes in patients with ovarian clear cell carcinoma (OCCC). We enrolled patients with OCCC (n = 80) and high-grade serous carcinoma (HGSC; n = 92) subjected to primary cytoreductive surgery, most of whom received platinum-based adjuvant chemotherapy. Genomic scar signatures based on genome-wide copy number data were determined in all participants and investigated in relation to prognosis...
May 3, 2018: Journal of Molecular Medicine: Official Organ of the "Gesellschaft Deutscher Naturforscher und Ärzte"
https://www.readbyqxmd.com/read/29725255/amacr-overexpression-acts-as-a-negative-prognostic-factor-in-oral-squamous-cell-carcinoma
#9
Hong-Lin He, Ying-En Lee, Min-Te Chang, Yow-Ling Shiue, Shih-Lun Chang, Tzu-Ju Chen, Chang-Ta Chiu
Background : Alpha-methylacyl-CoA racemase (AMACR) is a key enzyme responsible for the metabolism of branched-chain fatty acids. It has been found to be an important prognostic factor in numerous types of cancers. This study was aimed to investigate the expression of AMACR and its prognostic significance in patients with oral squamous cell carcinoma (SCC). Methods : Analysis of publicly available microarray data of oral SCC revealed that AMACR was significantly upregulated in tumor tissue compared with normal mucosa...
2018: International Journal of Medical Sciences
https://www.readbyqxmd.com/read/29722814/whole-genome-de-novo-sequencing-reveals-unique-genes-that-contributed-to-the-adaptive-evolution-of-the-mikado-pheasant
#10
Chien-Yueh Lee, Ping-Han Hsieh, Li-Mei Chiang, Amrita Chattopadhyay, Kuan-Yi Li, Yi-Fang Lee, Tzu-Pin Lu, Liang-Chuan Lai, En-Chung Lin, Hsinyu Lee, Shih-Torng Ding, Mong-Hsun Tsai, Chien-Yu Chen, Eric Y Chuang
Background: The Mikado pheasant (Syrmaticus mikado) is a nearly endangered species indigenous to high-altitude regions of Taiwan. This pheasant provides an opportunity to investigate evolutionary processes following geographic isolation. Currently, the genetic background and adaptive evolution of the Mikado pheasant remain unclear. Results: We present the draft genome of the Mikado pheasant, which consists of 1.04 Gb of DNA and 15,972 annotated protein-coding genes...
May 1, 2018: GigaScience
https://www.readbyqxmd.com/read/29721855/id1-and-sonic-hedgehog-mediate-cell-cycle-reentry-and-apoptosis-induced-by-amyloid-beta-peptide-in-post-mitotic-cortical-neurons
#11
A-Ching Chao, Chien-Hui Chen, Shih-Hsin Chang, Chao-Tzu Huang, Wei-Chao Hwang, Ding-I Yang
Amyloid beta-peptide (Aβ), the neurotoxic component of senile plaques in Alzheimer's disease (AD) brains, is known to trigger cell cycle reentry in post-mitotic neurons followed by apoptosis. However, the underlying mechanisms remain unclear. Recently, we have reported that Aβs stimulate the expression of inhibitor of differentiation-1 (Id1) to induce sonic hedgehog (SHH) (Hung et al., Mol Neurobiol 53(2):793-809, 2016), and both are mitogens capable of triggering cell cycle progression. In this work, we tested the hypothesis that Aβ-induced Id1 and SHH contribute to cell cycle reentry leading to apoptosis in neurons...
May 2, 2018: Molecular Neurobiology
https://www.readbyqxmd.com/read/29712909/widespread-intronic-polyadenylation-diversifies-immune-cell-transcriptomes
#12
Irtisha Singh, Shih-Han Lee, Adam S Sperling, Mehmet K Samur, Yu-Tzu Tai, Mariateresa Fulciniti, Nikhil C Munshi, Christine Mayr, Christina S Leslie
Alternative cleavage and polyadenylation (ApA) is known to alter untranslated region (3'UTR) length but can also recognize intronic polyadenylation (IpA) signals to generate transcripts that lose part or all of the coding region. We analyzed 46 3'-seq and RNA-seq profiles from normal human tissues, primary immune cells, and multiple myeloma (MM) samples and created an atlas of 4927 high-confidence IpA events represented in these cell types. IpA isoforms are widely expressed in immune cells, differentially used during B-cell development or in different cellular environments, and can generate truncated proteins lacking C-terminal functional domains...
April 30, 2018: Nature Communications
https://www.readbyqxmd.com/read/29704444/chromosome-level-assembly-genetic-and-physical-mapping-of-phalaenopsis-aphrodite-genome-provides-new-insights-into-species-adaptation-and-resources-for-orchid-breeding
#13
Ya-Ting Chao, Wan-Chieh Chen, Chun-Yi Chen, Hsiu-Yin Ho, Chih-Hsin Yeh, Yi-Tzu Kuo, Chun-Lin Su, Shao-Hua Yen, Hao-Yen Hsueh, Jen-Hau Yeh, Hui-Lan Hsu, Yi-Hui Tsai, Tzu-Yen Kuo, Song-Bin Chang, Kai-Yi Chen, Ming-Che Shih
The Orchidaceae is a diverse and ecologically important plant family. Approximately 69% of all orchid species are epiphytes, which provide diverse microhabitats for many small animals and fungi in the canopy of tropical rainforests. Moreover, many orchids are of economic importance as food flavorings or ornamental plants. Phalaenopsis aphrodite, an epiphytic orchid, is a major breeding parent of many commercial orchid hybrids. We provide a high-quality chromosome-scale assembly of the P. aphrodite genome. The total length of all scaffolds is 1025...
April 28, 2018: Plant Biotechnology Journal
https://www.readbyqxmd.com/read/29702353/reductive-amination-assistance-for-quantification-of-oseltamivir-phosphate-and-oseltamivir-carboxylate-by-hplc-ms-ms
#14
Mei-Fang Huang, Yi-Reng Lin, Yu-Tzu Chang, Yow-Ling Shiue, Shih-Shin Liang
Oseltamivir phosphate (OP) is the first line therapy for influenza, and its primary metabolite oseltamivir carboxylate (OC) is the active agent via inhibition of neuraminidase of influenza virus. Dosages of OP and OC might affect human causing nausea and vomiting and it is therefore necessary to evaluate their toxicity and safety. The separation system: liquid chromatography-tandem mass spectrometry (LC-MS/MS) is a powerful technique to monitor OP and OC. However, quantification of OP and OC needs isotopic analogs as internal standards to monitor the stability of the sample pretreatment procedures and instruments...
April 4, 2018: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/29695550/the-association-of-matrix-metalloproteinase-1-promoter-polymorphisms-with-breast-cancer
#15
Chieh-Lun Hsiao, Liang-Chih Liu, Tzu-Ching Shih, Yi-Liang Lai, Shih-Wei Hsu, Hwei-Chung Wang, Su-Yi Pan, Te-Chun Shen, Chia-Wen Tsai, Wen-Shin Chang, Chen-Hsien Su, Tzong-DER Way, Jing-Gung Chung, DA-Tian Bau
BACKGROUND/AIM: The family of matrix metalloproteinases (MMPs) are responsible for the homeostasis of extracellular matrix components and their genetic polymorphisms may be associated with cancer susceptibility. The serum levels of MMP-1 have been reported to be lower in breast cancer patients than healthy subjects. In the current study, we aimed at investigating the contribution of a polymorphism in the promoter region of MMP-1 to breast cancer in Taiwan. MATERIALS AND METHODS: The MMP-1 rs1799705 polymorphic genotypes were genotyped among 1,232 breast cancer patients and 1,232 healthy controls by the typical polymerase chain reaction-restriction fragment length polymorphism methodology...
May 2018: In Vivo
https://www.readbyqxmd.com/read/29674400/recognition-of-supraduodenal-artery-from-hepatic-artery-is-essential-to-avoid-untoward-complications-at-haic-two-cases
#16
Tzu-Hao Ou, Ding-Kwo Wu, Paul Ming-Chen Shih, Min-Fang Chao
No abstract text is available yet for this article.
April 19, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29673672/associations-between-a-single-nucleotide-polymorphism-of-stress-induced-phosphoprotein-1-and-endometriosis-adenomyosis
#17
Chia-Lung Tsai, Yun-Shien Lee, Angel Chao, Chih-Feng Yen, Hsin-Shih Wang, Tzu-Hao Wang
OBJECTIVE: We have recently reported that stress-induced phosphoprotein 1 (STIP1) is over-expressed in endometriosis/adenomyosis tissues. STIP1 may also be involved in immune regulation, thus we attempted to study the association between STIP1 single nucleotide polymorphisms (SNPs) and endometriosis/adenomyosis. MATERIALS AND METHODS: Five STIP1 SNPs (rs7941773, rs2845597, rs4980524, rs2282490, and rs2236647) were selected for genotyping with matrix-assisted laser desorption ionization time-of-flight mass spectrometry (MALDI-TOF MS) in 286 patients with endometriosis/adenomyosis and 288 healthy postmenopausal controls...
April 2018: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/29651899/caffeine-does-not-affect-susceptibility-to-cortical-spreading-depolarization-in-mice
#18
Nilufer Yalcin, Shih-Pin Chen, Esther S Yu, Tzu-Ting Liu, Jiin-Cherng Yen, Yahya B Atalay, Tao Qin, Furkan Celik, Arn Mjm van den Maagdenberg, Michael A Moskowitz, Cenk Ayata, Katharina Eikermann-Haerter
Several factors that modulate migraine, a common primary headache disorder, also affect susceptibility to cortical spreading depolarization (CSD). CSD is a wave of neuronal and glial depolarization and thought to underlie the migraine aura and possibly headache. Here, we tested whether caffeine, known to alleviate or trigger headache after acute exposure or chronic use/withdrawal, respectively, modulates CSD. We injected C57BL/6J mice with caffeine (30, 60, or 120 mg/kg; i.p.) once (acute) or twice per day for one or two weeks (chronic)...
January 1, 2018: Journal of Cerebral Blood Flow and Metabolism
https://www.readbyqxmd.com/read/29643378/the-value-of-radial-endobronchial-ultrasound-guided-bronchial-brushing-in-peripheral-non-squamous-non-small-cell-lung-cancer
#19
Kai-Lun Yu, Tzu-Hsiu Tsai, Chao-Chi Ho, Wei-Yu Liao, Ching-Kai Lin, Chia-Lin Hsu, Jin-Yuan Shih
Radial endobronchial ultrasound (R-EBUS) is one important diagnostic approach in non-small cell lung cancers (NSCLC). However, the small samples obtained from R-EBUS-guided transbronchial biopsies are sometimes insufficient for pathological and molecular diagnosis. Herein, we investigated the suitability of R-EBUS-guided bronchial brushing specimens for NSCLC diagnosis and EGFR genotyping. We enrolled 941 consecutive patients with peripheral pulmonary lesions who underwent R-EBUS. Cytology-positive brushing specimens from non-squamous NSCLC patients were tested for EGFR mutations...
April 11, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29599337/the-association-of-matrix-metalloproteinase-8-promoter-genotypes-in-breast-cancer
#20
Chieh-Lun Hsiao, Liang-Chih Liu, Tzu-Ching Shih, Chin-Liang Chuang, Guan-Liang Chen, Hwei-Chung Wang, Su-Yi Pan, Te-Chun Shen, Chia-Wen Tsai, Wen-Shin Chang, Tzong-DER Way, Jing-Gung Chung, DA-Tian Bau
BACKGROUND/AIM: The family of matrix metalloproteinases (MMPs) controls homeostasis of the extracellular matrix and their genetic polymorphisms may be associated with personal cancer susceptibility. The serum levels of MMP8 was reported to be higher in patients with breast cancer than in healthy individuals. In this study, we aimed to investigate the contribution of a polymorphism in the promoter region of MMP8 (-799C/T) and two nonsynonymous polymorphisms (Val436Ala and Lys460Thr) to breast cancer...
April 2018: Anticancer Research
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