keyword
MENU ▼
Read by QxMD icon Read
search

Shih tzu

keyword
https://www.readbyqxmd.com/read/28537895/interaction-of-glycosphingolipids-gd3-and-gd2-with-growth-factor-receptors-maintains-breast-cancer-stem-cell-phenotype
#1
Yuh-Jin Liang, Chen-Yu Wang, I-An Wang, Yi-Wen Chen, Li-Tzu Li, Chuang-Yu Lin, Ming-Yi Ho, Tsung-Lung Chou, Ya-Hui Wang, Shih-Pin Chiou, Yu-Ju Lin, John Yu
Many studies have suggested that disialogangliosides, GD2 and GD3, are involved in the development of various tumor types. However, the functional relationships between ganglioside expression and cancer development or aggressiveness are not fully described. GD3 is upregulated in approximately half of all invasive ductal breast carcinoma cases, and enhanced expression of GD3 synthase (GD3S, alpha-N-acetylneuraminide alpha-2,8-sialyltransferase) in estrogen receptor-negative breast tumors, was shown to correlate with reduced overall patient survival...
May 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28528695/protein-phosphatase-5-promotes-hepatocarcinogenesis-through-interaction-with-amp-activated-protein-kinase
#2
Yao-Li Chen, Man-Hsin Hung, Pei-Yi Chu, Tzu-I Chao, Ming-Hsien Tsai, Li-Ju Chen, Yung-Jen Hsiao, Chih-Ting Shih, Feng-Shu Hsieh, Kuen-Feng Chen
The serine-threonine protein phosphatase family members are known as critical regulators of various cellular functions, such as survival and transformation. Growing evidence suggests that pharmacological manipulation of phosphatase activity exhibits therapeutic benefits. Ser/Thr protein phosphatase 5 (PP5) is known to participate in glucocorticoid receptor (GR) and stress-induced signaling cascades that regulate cell growth and apoptosis, and has been shown to be overexpressed in various human malignant diseases...
May 18, 2017: Biochemical Pharmacology
https://www.readbyqxmd.com/read/28515452/trends-and-outcomes-of-surgical-treatment-for-colorectal-cancer-between-2004-and-2012-an-analysis-using-national-inpatient-database
#3
Meng-Tse Gabriel Lee, Chong-Chi Chiu, Chia-Chun Wang, Chia-Na Chang, Shih-Hao Lee, Matthew Lee, Tzu-Chun Hsu, Chien-Chang Lee
Limited data are available for the epidemiology and outcome of colorectal cancer in relation to the three main surgical treatment modalities (open, laparoscopic and robotic). Using the US National Inpatient Sample database from 2004 to 2012, we identified 1,265,684 hospitalized colorectal cancer patients. Over the 9 year period, there was a 13.5% decrease in the number of hospital admissions and a 43.5% decrease in in-hospital mortality. Comparing the trend of surgical modalities, there was a 35.4% decrease in open surgeries, a 3...
May 17, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28501315/endovascular-stenting-for-end-stage-lung-cancer-patients-with-superior-vena-cava-syndrome-post-first-line-treatments-a-single-center-experience-and-literature-review
#4
Tzu-Ting Kuo, Po-Lin Chen, Chun-Che Shih, I-Ming Chen
BACKGROUND: Superior vena cava (SVC) syndrome is a major complication that occurs when a growing lung malignancy compresses the SVC extrinsically. Current treatment options include radiotherapy or chemotherapy to shrink the tumor or endovascular stenting of the SVC to restore flow. Herein, we report a case series treated in a single institution to demonstrate the safety, effectiveness, and outcomes of salvage and primary stenting for malignant SVC obstruction. METHODS: A total of 12 male patients with malignant superior vena cava obstruction caused by lung cancer underwent SVC stenting from October 2009 to May 2015...
May 10, 2017: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/28501000/combination-of-a-biodegradable-three-dimensional-3d-printed-cage-for-mechanical-support-and-nanofibrous-membranes-for-sustainable-release-of-antimicrobial-agents-for-treating-the-femoral-metaphyseal-comminuted-fracture
#5
Ying-Chao Chou, Demei Lee, Tzu-Min Chang, Yung-Heng Hsu, Yi-Hsun Yu, Err-Cheng Chan, Shih-Jung Liu
The aim of this study was to develop a biodegradable three-dimensional-printed polylactide (PLA) cage for promoting bony fixation and an antibiotics-embedded poly(d,l)-lactide-co-glycolide (PLGA) nanofibrous membrane for infectious prophylaxis during treating the comminuted metaphyseal fracture in a rabbit femoral model. The in vitro studies included measuring the mechanical properties of the 3D printed cage and determining release activities of vancomycin and ceftazidime from the nanofibers. The in vivo study included comparisons of rabbits of the femoral metaphyseal comminuted fracture treated with or without the combined biodegradable polymers...
May 2, 2017: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/28488107/long-term-perceptions-of-outdoor-thermal-environments-in-an-elementary-school-in-a-hot-humid-climate
#6
Wen-Mei Shih, Tzu-Ping Lin, Ning-Xin Tan, Mu-Hsien Liu
Previous studies on thermal comfort in school environments have focused more on indoor thermal environments than outdoor ones, thus providing a limited understanding of occupants' long-term thermal perceptions. Taiwan is located in a subtropical region, where it can be stiflingly hot outside in summer. This highlights the need to ensure proper thermal comfort on campus. In the present study, thermal environment parameters were measured and collected in several outdoor spaces of an elementary school in southern Taiwan...
May 10, 2017: International Journal of Biometeorology
https://www.readbyqxmd.com/read/28453226/palbociclib-induces-activation-of-ampk-and-inhibits-hepatocellular-carcinoma-in-a-cdk4-6-independent-manner
#7
Feng-Shu Hsieh, Yao-Li Chen, Man-Hsin Hung, Pei-Yi Chu, Ming-Hsien Tsai, Li-Ju Chen, Yung-Jen Hsiao, Chih-Ting Shih, Mao-Ju Chang, Tzu-I Chao, Chung-Wai Shiau, Kuen-Feng Chen
Palbociclib, a CDK4/6 inhibitor, has recently been approved for hormone receptor-positive breast cancer patients. The effects of palbociclib as a treatment for other malignancies, including hepatocellular carcinoma (HCC), are of great clinical interest and are under active investigation. Here, we report the effects and a novel mechanism of action of palbociclib in HCC. We found that palbociclib induced both autophagy and apoptosis in HCC cells through a mechanism involving 5' AMP-activated protein kinase (AMPK) activation and protein phosphatase 5 (PP5) inhibition...
April 28, 2017: Molecular Oncology
https://www.readbyqxmd.com/read/28422732/molecular-and-serologic-markers-of-hpv-16-infection-are-associated-with-local-recurrence-in-patients-with-oral-cavity-squamous-cell-carcinoma
#8
Chung-Guei Huang, Li-Ang Lee, Chun-Ta Liao, Tzu-Chen Yen, Shu-Li Yang, Yi-Chun Liu, Jung-Chin Li, Yu-Nong Gong, Chung-Jan Kang, Shiang-Fu Huang, Ku-Hao Fang, Kai-Ping Chang, Li-Yu Lee, Chuen Hsueh, Shin-Ru Shih, Kuo-Chien Tsao
Human papillomavirus (HPV) infections predict mortality in Taiwanese patients with oral cavity squamous cell carcinoma (OCSCC). To address their prognostic significance for local recurrence (LR), in this retrospective cohort study we investigated different serologic and molecular markers of HPV 16 infection in 85 consecutive patients with primary OCSCC who received standard treatment and had their sera stored before treatment. Resected tumor specimens were examined with PCR-based assays for HPV 16 E6/E7 mRNA expression...
May 23, 2017: Oncotarget
https://www.readbyqxmd.com/read/28402333/maoa-a-novel-decision-maker-of-apoptosis-and-autophagy-in-hormone-refractory-neuroendocrine-prostate-cancer-cells
#9
Yi-Cheng Lin, Yi-Ting Chang, Mel Campbell, Tzu-Ping Lin, Chin-Chen Pan, Hsin-Chen Lee, Jean C Shih, Pei-Ching Chang
Autophagy and apoptosis are two well-controlled mechanisms regulating cell fate. An understanding of decision-making between these two pathways is in its infancy. Monoamine oxidase A (MAOA) is a mitochondrial enzyme that is well-known in psychiatric research. Emerging reports showed that overexpression MAOA is associated with prostate cancer (PCa). Here, we show that MAOA is involved in mediating neuroendocrine differentiation of PCa cells, a feature associated with hormone-refractory PCa (HRPC), a lethal type of disease...
April 12, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28399706/sampling-design-by-the-core-food-approach-for-the-taiwan-total-diet-study-on-veterinary-drugs
#10
Chien-Chih Chen, Ching-Lun Tsai, Chia-Chin Chang, Shih-Pei Ni, Yi-Tzu Chen, Chow-Feng Chiang
The core-food (CF) approach, first adopted in the United States in the 1980s, has been widely used by many countries to assess the exposure to dietary hazards at a population level. However, the reliability of exposure estimates (C × CR) depends critically on sampling methods designed for the detected chemical concentrations (C) of each CF to match with the corresponding consumption rate (CR) estimated from the surveyed intake data. In order to reduce the uncertainty of food matching, this study presents a sampling design scheme, namely the subsample method, for the 2016 Taiwan total diet study (TDS) on veterinary drugs...
May 17, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28387117/performance-characterization-of-dye-sensitized-photovoltaics-under-indoor-lighting
#11
Chia-Yuan Chen, Zih-Hong Jian, Shih-Han Huang, Kun-Mu Lee, Ming-Hsuan Kao, Chang-Hong Shen, Jia-Min Shieh, Chin-Li Wang, Chiung-Wen Chang, Bo-Zhi Lin, Ching-Yao Lin, Ting-Kuang Chang, Yun Chi, Cheng-Yu Chi, Wei-Ting Wang, Yian Tai, Ming-De Lu, Yung-Liang Tung, Po-Ting Chou, Wen-Ti Wu, Tahsin J Chow, Peter Chen, Xiang-Hao Luo, Yuh-Lang Lee, Chih-Chung Wu, Chih-Ming Chen, Chen-Yu Yeh, Miao-Syuan Fan, Jia-De Peng, Kuo-Chuan Ho, Yu-Nan Liu, Hsiao-Yi Lee, Chien-Yu Chen, Hao-Wu Lin, Chia-Te Yen, Yu-Ching Huang, Cheng-Si Tsao, Yu-Chien Ting, Tzu-Chien Wei, Chun-Guey Wu
Indoor utilization of emerging photovoltaics is promising; however, efficiency characterization under room lighting is challenging. We report the first round-robin interlaboratory study of performance measurement for dye-sensitized photovoltaics (cells and mini-modules) and one silicon solar cell under a fluorescent dim light. Among 15 research groups, the relative deviation in power conversion efficiency (PCE) of the samples reaches an unprecedented 152%. On the basis of the comprehensive results, the gap between photometry and radiometry measurements and the response of devices to the dim illumination are identified as critical obstacles to the correct PCE...
April 20, 2017: Journal of Physical Chemistry Letters
https://www.readbyqxmd.com/read/28363832/primary-cns-lymphomas-of-the-brain-a-retrospective-analysis-in-a-single-institute
#12
Tzu-Kang Lin, Tu-Hsueh Yeh, Peng-Wei Hsu, Chih-Cheng Chuang, Po-Hsun Tu, Pin-Yuang Chen, Shih-Ming Jung, Kuo-Chen Wei, Yin-Cheng Huang
Primary CNS lymphomas (PCNSL) are relatively rare brain tumors. Their accurate diagnosis is mainly by surgical biopsy. In addition to surgical biopsy/decompression, treatment options include high dose methotrexate/chemotherapy and radiation therapy and stem cell therapy. Due to the rarity of this disease, guidelines for PCNSL diagnosis and treatment usually form from a large series of experiences. As a tertiary referral center, we retrospectively reviewed 79 patients during a 13-year period. All patients with PCNSL underwent surgical procedures/bone marrow biopsy procedures, and diagnoses were confirmed by hematologists/neuropathologists...
March 28, 2017: World Neurosurgery
https://www.readbyqxmd.com/read/28363770/lectin-functionalized-mesoporous-silica-nanoparticles-for-endoscopic-detection-of-premalignant-colonic-lesions
#13
Nai-Tzu Chen, Jeffrey S Souris, Shih-Hsun Cheng, Chia-Hui Chu, Yu-Chao Wang, Vani Konda, Urszula Dougherty, Marc Bissonnette, Chung-Yuan Mou, Chin-Tu Chen, Leu-Wei Lo
Colorectal cancer (CRC) is one of the leading causes of cancer-deaths worldwide. Methods for the early in situ detection of colorectal adenomatous polyps and their precursors - prior to their malignancy transformation into CRC - are urgently needed. Unfortunately at present, the primary diagnostic method, colonoscopy, can only detect polyps and carcinomas by shape/morphology; with sessile polyps more likely to go unnoticed than polypoid lesions. Here we describe our development of polyp-targeting, fluorescently-labeled mesoporous silica nanoparticles (MSNs) that serve as targeted endoscopic contrast agents for the early detection of colorectal polyps and cancer...
March 29, 2017: Nanomedicine: Nanotechnology, Biology, and Medicine
https://www.readbyqxmd.com/read/28350247/the-transgenic-zebrafish-display-fluorescence-reflecting-the-expressional-dynamics-of-dihydrofolate-reductase
#14
Wen-Ni Chang, Wan-Yu Chi, Tseng-Ting Kao, Jen-Ning Tsai, Wangta Liu, Shih-Shin Liang, Chien-Chih Chiu, Bing-Hung Chen, Tzu-Fun Fu
Dihydrofolate reductase (DHFR) reduces folic acid and recycles dihydrofolate generated during dTMP biosynthesis to tetrahydrofolate. DHFR is upregulated in rapidly proliferating cells and hence a favored target of antifolate drug against cancers, autoimmune diseases, and microbial infections. However, increased expression of dhfr contributed to the often emerging drug resistance and impeded the therapeutic efficacy of antifolate drugs. Therefore, comprehensive knowledge on the expressional control of dhfr becomes crucial...
March 28, 2017: Zebrafish
https://www.readbyqxmd.com/read/28347882/subsyndromal-psychosomatic-concepts-and-personality-traits-in-community-adults
#15
Shih-Cheng Liao, I-Ming Chen, Chao-Ying Tu, Chih-Kang Hsu, Huei-Mei Ma, Min-Tzu Lee, Wei-Lieh Huang
OBJECTIVE: To investigate the prevalence of features of the Diagnostic Criteria for Psychosomatic Research (DCPR) in the Taiwanese community and to explore their relationships with psychological states and personality traits. METHOD: The participants were 153 individuals without a DSM-5 psychiatric diagnosis who were grouped according to whether they had a DCPR diagnosis (at least one DCPR diagnosis, DCPR(+): n=66; no DCPR diagnosis, DCPR(-): n=87). The groups were compared with respect to psychological states (measured with Patient Health Questionnaire-15 [PHQ-15], Health Anxiety Questionnaire [HAQ], Beck Depression Inventory-II [BDI-II], Beck Anxiety Inventory [BAI)]) and personality (measured with Tridimensional Personality Questionnaire)...
May 2017: Comprehensive Psychiatry
https://www.readbyqxmd.com/read/28342207/genetic-effect-of-mthfr-c677t-polymorphism-on-the-structural-covariance-network-and-white-matter-integrity-in-alzheimer-s-disease
#16
Yu-Tzu Chang, Shih-Wei Hsu, Shih-Jen Tsai, Ya-Ting Chang, Chi-Wei Huang, Mu-En Liu, Nai-Ching Chen, Wen-Neng Chang, Jung-Lung Hsu, Chen-Chang Lee, Chiung-Chih Chang
The 677 C to T transition in the MTHFR gene is a genetic determinant for hyperhomocysteinemia. We investigated whether this polymorphism modulates gray matter (GM) structural covariance networks independently of white-matter integrity in patients with Alzheimer's disease (AD). GM structural covariance networks were constructed by 3D T1-magnetic resonance imaging and seed-based analysis. The patients were divided into two genotype groups: C homozygotes (n = 73) and T carriers (n = 62). Using diffusion tensor imaging and white-matter parcellation, 11 fiber bundle integrities were compared between the two genotype groups...
June 2017: Human Brain Mapping
https://www.readbyqxmd.com/read/28334420/evaluation-of-hydraulic-properties-of-aquitards-using-earthquake-triggered-groundwater-variation
#17
Shih-Jung Wang, Kuo-Chin Hsu, Chein-Lee Wang, Wen-Chi Lai, Liang-Tzu Hsu
The hydraulic properties of aquitards are not easily obtained because monitoring wells are usually installed in aquifers for groundwater resources management. Earthquake-induced crust stress (strain) triggers groundwater level variations over a short period of time in a large area. These groundwater anomalies can be used to investigate aquifer systems. This study uses a poroelastic model to fit the postseismic variations of groundwater level triggered by the Chi-Chi earthquake to evaluate the hydraulic properties of aquitards in the Jhoushuei River alluvial fan (JRAF), Taiwan...
March 23, 2017: Ground Water
https://www.readbyqxmd.com/read/28326983/morphologic-and-morphometric-description-of-the-temporomandibular-joint-in-the-domestic-dog-using-computed-tomography
#18
Lenin A Villamizar-Martinez, Cristian M Villegas, Marco A Gioso, Alexander M Reiter, Geni C Patricio, Ana C Pinto
The temporomandibular joint (TMJ) in the domestic dog is a synovial joint with 2 articular surfaces, the mandibular fossa of the squamous portion of the temporal bone and the articular head of the condylar process of the mandible. Although different diagnostic imaging techniques have been used to study the TMJ in dogs, morphologic and morphometric studies based on computed tomography (CT) are scarce. The purpose of the present study was to describe the morphologic and morphometric features of the TMJ in domestic dogs using CT...
June 2016: Journal of Veterinary Dentistry
https://www.readbyqxmd.com/read/28296534/trends-of-do-not-resuscitate-orders-hospice-care-utilization-and-late-referral-to-hospice-care-among-cancer-decedents-in-a-tertiary-hospital-in-taiwan-between-2008-and-2014-a-hospital-based-observational-study
#19
Tzu-Chien Shih, Hsiao-Ting Chang, Ming-Hwai Lin, Chun-Ku Chen, Tzeng-Ji Chen, Shinn-Jang Hwang
BACKGROUND: Out of respect for terminal patients' dignity and to decrease end-of-life suffering, patients in Taiwan can choose to sign do-not-resuscitate (DNR) orders and use hospice care when they are in a terminal condition. OBJECTIVES: To explore the trends and characteristics of hospice care utilization and DNR status among terminal cancer patients. Design and Setting/Subjects: A secondary data analysis was conducted to examine the rate of DNR orders, hospice care utilization, the survival time after DNR order, the duration of survival (DOS) after hospice care enrollment, and the rate of late referral to hospice care among patients who died from malignant cancers in a tertiary hospital in Taiwan between 2008 and 2014...
March 15, 2017: Journal of Palliative Medicine
https://www.readbyqxmd.com/read/28294485/structure-of-the-complex-between-a-heparan-sulfate-octasaccharide-and-mycobacterial-heparin-binding-hemagglutinin
#20
Teng-Yi Huang, Deli Irene, Medel Manuel L Zulueta, Tzu-Jui Tai, Shih-Han Lain, Cheng-Po Cheng, Ping-Xi Tsai, Shu-Yi Lin, Zhi-Geng Chen, Chiao-Chu Ku, Chwan-Deng Hsiao, Chia-Lin Chyan, Shang-Cheng Hung
Heparin-binding hemagglutinin (HBHA) is a 199 amino acid virulence factor at the envelope of Mycobacterium tuberculosis that contributes to latent tuberculosis. The binding of HBHA to respiratory epithelial cells, which leads to extrapulmonary dissemination of the pathogen, is mediated by cell-surface heparan sulfate (HS). We report the structural characterization of the HBHA/HS complex by NMR spectroscopy. To develop a model for the molecular recognition, the first chemically synthesized uniformly (13) C- and (15) N-labeled HS octasaccharide and a uniformly (13) C- and (15) N-labeled form of HBHA were prepared...
April 3, 2017: Angewandte Chemie
keyword
keyword
23224
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"