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https://www.readbyqxmd.com/read/27907908/prevalence-and-clinical-significance-of-brca1-2-germline-and-somatic-mutations-in-taiwanese-patients-with-ovarian-cancer
#1
Angel Chao, Ting-Chang Chang, Nina Lapke, Shih-Ming Jung, Peter Chi, Chien-Hung Chen, Lan-Yan Yang, Cheng-Tao Lin, Huei-Jean Huang, Hung-Hsueh Chou, Jui-Der Liou, Shu-Jen Chen, Tzu-Hao Wang, Chyong-Huey Lai
Germline and somatic BRCA1/2 mutations define a subset of patients with ovarian cancer who may benefit from treatment with poly (ADP-ribose) polymerase inhibitors. Unfortunately, data on the frequency of BRCA1/2 germline mutations in Taiwanese patients with ovarian cancer are scarce, with the prevalence of somatic mutations being unknown. We aim to investigate the occurrence of BRCA1/2 mutations in 99 Taiwanese patients with ovarian cancer which included serous (n = 46), endometrioid (n = 24), and clear cell (n = 29) carcinomas...
November 19, 2016: Oncotarget
https://www.readbyqxmd.com/read/27898174/treatment-of-a-giant-pulmonary-emphysematous-cyst-with-primary-bronchoalveolar-papillary-carcinoma-in-a-shih-tzu-dog
#2
Jiyoung Park, Hae-Beom Lee, Seong Mok Jeong
OBJECTIVE: To report the surgical treatment of a pulmonary emphysematous cyst concurrent with primary pulmonary bronchoalveolar papillary carcinoma in a dog. STUDY DESIGN: Clinical case report. ANIMALS: 12-year-old 6.4 kg spayed female Shih Tzu dog. METHODS: The dog presented for surgical treatment of pulmonary emphysema. Radiography revealed that more than half of the left caudal lung lobe was enlarged and hyperlucent and computed tomography (CT) confirmed the presence of an emphysematous space...
November 28, 2016: Veterinary Surgery: VS
https://www.readbyqxmd.com/read/27890705/selective-rehearsal-is-affected-by-the-emotionality-of-the-encoding-context-in-item-method-directed-forgetting-an-event-related-potential-study
#3
Tzu-Ling Liu, Nai-Feng Chen, Shih-Kuen Cheng
Emotional items are often remembered more clearly than neutral items. However, whether stimuli embedded in an emotional context are more resistant to directed forgetting than those presented in a neutral context remains unclear. This question was tested by recording event-related potentials (ERPs) in an item-method directed forgetting paradigm involving neutral words that were embedded in neutral or negative contexts. During the study phase, participants were asked to associate a neutral word with a negative or neutral picture...
November 24, 2016: Biological Psychology
https://www.readbyqxmd.com/read/27889462/maternal-and-umbilical-cord-blood-levels-of-mercury-manganese-iron-and-copper-in-southern-taiwan-a-cross-sectional-study
#4
Shih-Hui Huang, Ken-Pen Weng, Ching-Chiang Lin, Chung-Cheng Wang, Charles Tzu-Chi Lee, Luo-Ping Ger, Ming-Tsang Wu
BACKGROUND: The effect of maternal exposure to essential minerals and heavy metals on fetus is an important issue, which affects women around the world. Few data are available on the concentration of both essential minerals and heavy metals in maternal/fetal medicine. The aims of this study were to (1) assess the correlation of mercury (Hg), manganese (Mn), iron (Fe), and copper (Cu) in paired maternal/fetal blood samples, and (2) study potential confounding factors during pregnancy. METHODS: Our study recruited 145 healthy pregnant women with a mean age of 28...
November 23, 2016: Journal of the Chinese Medical Association: JCMA
https://www.readbyqxmd.com/read/27888621/intraperitoneal-ziv-aflibercept-effectively-manages-refractory-ascites-in-colorectal-cancer-patients
#5
Chieh-Sheng Lu, Jen-Kou Lin, Wei-Shone Chen, Tzu-Chen Lin, Jeng-Kai Jiang, Shung-Haur Yang, Huann-Sheng Wang, Shih-Ching Chang, Yuan-Tzu Lan, Chun-Chi Lin, Hung-Hsin Lin, Hao-Wei Teng
Ascites related to metastatic colorectal cancer (mCRC) reduces patient survival and quality of life, and systemic chemotherapy is largely ineffective for managing ascites. Here, we examined the clinical efficacy of intraperitoneal (IP) ziv-aflibercept for managing refractory ascites in 15 mCRC patients who did not respond to standard chemotherapy. Fifty or 100 mg of ziv-aflibercept in 100 mL of saline solution were infused through a pigtail catheter and retained for 24 h. When the ascites drainage volumes were subsequently monitored, 73...
November 24, 2016: Oncotarget
https://www.readbyqxmd.com/read/27866313/two-myb-related-transcription-factors-play-opposite-roles-in-sugar-signaling-in-arabidopsis
#6
Yi-Shih Chen, Yi-Chi Chao, Tzu-Wei Tseng, Chun-Kai Huang, Pei-Ching Lo, Chung-An Lu
Sugar regulation of gene expression has profound effects at all stages of the plant life cycle. Although regulation at the transcriptional level is one of the most prominent mechanisms by which gene expression is regulated, only a few transcription factors have been identified and demonstrated to be involved in the regulation of sugar-regulated gene expression. OsMYBS1, an R1/2-type MYB transcription factor, has been demonstrated to be involved in sugar- and hormone-regulated α-amylase gene expression in rice...
November 19, 2016: Plant Molecular Biology
https://www.readbyqxmd.com/read/27859216/cooperation-of-mll-af10-om-lz-with-ptpn11-activating-mutation-induced-monocytic-leukemia-with-a-shorter-latency-in-a-mouse-bone-marrow-transplantation-model
#7
Jen-Fen Fu, Sung-Tzu Liang, Ying-Jung Huang, Kung-Hao Liang, Tzung-Hai Yen, Der-Cherng Liang, Lee-Yung Shih
PTPN11 mutation, a RAS signaling pathway mutation, is associated with MLL translocations in acute leukemia. A girl with MLL/AF10 AML was found to carry PTPN11(G503A) . To study the impact of PTPN11 (G503A) cooperating with MLL/AF10 on leukemogenesis, we established a retroviral transduction/transplantation mouse model. Compared with the MLL/AF10(OM-LZ) leukemia cells harboring PTPN11 (wt) , the cells harboring PTPN11(G503A) were hypersensitive to GM-CSF and IL3, and more resistant to death upon treatment with daunorubicin but sensitive to cytarabine...
November 14, 2016: International Journal of Cancer. Journal International du Cancer
https://www.readbyqxmd.com/read/27858865/medical-care-utilization-and-costs-on-end-of-life-cancer-patients-the-role-of-hospice-care
#8
Hsiao-Ting Chang, Ming-Hwai Lin, Chun-Ku Chen, Tzeng-Ji Chen, Shu-Lin Tsai, Shao-Yi Cheng, Tai-Yuan Chiu, Shih-Tzu Tsai, Shinn-Jang Hwang
Although there are 3 hospice care programs for terminal cancer patients in Taiwan, the medical utilization and expenses for these patients by programs have not been well-explored. The aim of this study was to examine the medical utilization and expenses of terminal cancer patients under different programs of hospice care in the last 90, 30, and 14 days of life.This was a retrospective observational study by secondary data analysis. By using the National Health Insurance claim database and Hospice Shared Care Databases...
November 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27855722/prognostic-impact-of-restored-sinus-rhythm-in-patients-with-sepsis-and-new-onset-atrial-fibrillation
#9
Wen Cheng Liu, Wen Yu Lin, Chin Sheng Lin, Han Bin Huang, Tzu Chiao Lin, Shu Meng Cheng, Shih Ping Yang, Jung Chung Lin, Wei Shiang Lin
BACKGROUND: New-onset atrial fibrillation (NeOAF) is a common type of tachyarrhythmia in critically ill patients and is associated with increased mortality in patients with sepsis. However, the prognostic impact of restored sinus rhythm (SR) in septic patients with NeOAF remains unclear. METHODS: A total of 791 patients with sepsis, who were admitted to a medical intensive care unit from January 2011 to January 2014, were screened. NeOAF was detected by continuous electrocardiographic monitoring...
November 18, 2016: Critical Care: the Official Journal of the Critical Care Forum
https://www.readbyqxmd.com/read/27847105/corrigendum-to-defining-risk-groups-of-patients-with-cancer-of-unknown-primary-site-and-cervical-nodal-metastases-by-f-18-fluorodeoxyglucose-positron-emission-tomography-and-computed-tomography-imaging-kaohsiung-j-med-sci-32-08-2016-407-413
#10
Yung-Yueh Su, Shih-Hsin Chen, Chia-Hsun Hsieh, Chun-Ta Liao, Chien-Yu Lin, Chung-Jan Kang, Tzu-Chen Yen
No abstract text is available yet for this article.
November 2016: Kaohsiung Journal of Medical Sciences
https://www.readbyqxmd.com/read/27845443/imaging-cytometry-of-human-leukocytes-with-third-harmonic-generation-microscopy
#11
Cheng-Ham Wu, Tzung-Dau Wang, Chia-Hung Hsieh, Shih-Hung Huang, Jong-Wei Lin, Szu-Chun Hsu, Hau-Tieng Wu, Yao-Ming Wu, Tzu-Ming Liu
Based on third-harmonic-generation (THG) microscopy and a k-means clustering algorithm, we developed a label-free imaging cytometry method to differentiate and determine the types of human leukocytes. According to the size and average intensity of cells in THG images, in a two-dimensional scatter plot, the neutrophils, monocytes, and lymphocytes in peripheral blood samples from healthy volunteers were clustered into three differentiable groups. Using these features in THG images, we could count the number of each of the three leukocyte types both in vitro and in vivo...
November 15, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27833027/bufalin-inhibits-gefitinib-resistant-nci-h460-human-lung-cancer-cell-migration-and-invasion-in-vitro
#12
An-Cheng Huang, Mei-Due Yang, Yung-Ting Hsiao, Tzu-Shun Lin, Yi-Shih Ma, Shu-Fen Peng, Te-Chun Hsia, Yih-Dih Cheng, Chao-Lin Kuo, Jing-Gung Chung
ETHNOPHARMACOLOGICAL RELEVANCE: Bufalin, a component of Chan Su (frog), has been shown to have biological activities including anti-tumor effects. Gefitinib has been used as an anti-cancer drug in lung cancer patients; however, some patients eventually become gefitinib resistant. AIM OF THE STUDY: In this study, we investigated anti-metastasis effects of bufalin in gefitinib resistant NCI-H460 lung cancer cells. MATERIALS AND METHODS: The effects of the bufalin in gefitinib resistant NCI-H460 lung cancer cells were investigated on cell viability using flow cytometry...
November 7, 2016: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/27798648/association-of-fluid-status-and-body-composition-with-physical-function-in-patients-with-chronic-kidney-disease
#13
Shih-Ming Hsiao, Yi-Chun Tsai, Hui-Mei Chen, Ming-Yen Lin, Yi-Wen Chiu, Tzu-Hui Chen, Shu-Li Wang, Pei-Ni Hsiao, Lan-Fang Kung, Shang-Jyh Hwang, Mei-Feng Huang, Yi-Chun Yeh, Cheng-Sheng Chen, Mei-Chuan Kuo
BACKGROUND: Impairment of physical function and abnormal body composition are the major presentations in patients with chronic kidney disease (CKD). The aim of this study is to investigate the relationship between body composition and physical function in CKD patients. METHODS: This cross-sectional study enrolled 172 of CKD stages 1-5 from February 2013 to September 2013. Handgrip strength (upper extremity muscle endurance), 30-second chair-stand test (lower extremity muscle endurance) and 2-minute step test (cardiorespiratory endurance) were used as indices of physical function...
2016: PloS One
https://www.readbyqxmd.com/read/27779103/functional-variant-of-the-p2x7-receptor-gene-is-associated-with-human-papillomavirus-16-positive-cervical-squamous-cell-carcinoma
#14
Yuh-Cheng Yang, Tzu-Yang Chang, Tze-Chien Chen, Wen-Shan Lin, Shih-Chuan Chang, Yann-Jinn Lee
Human papillomavirus (HPV) infection and the fate of HPV infected cervical epithelial cells are strictly associated with cervical cancer development. P2X7 receptor has been implicated in both the regulation of immune responses and apoptosis of cervical cancer cells. The study aims to investigate if polymorphisms in the P2RX7 gene are associated with the risk of cervical cancer in Taiwanese women. P2RX7 253 T/C, 835 G/A, and 1513 A/C loss-of-function polymorphisms were genotyped in a hospital-based study of 507 women with cervical squamous cell carcinoma (CSCC) and 1619 age-matched healthy control women...
October 13, 2016: Oncotarget
https://www.readbyqxmd.com/read/27760993/long-term-surgical-outcome-and-prognostic-factors-of-atypical-and-malignant-meningiomas
#15
Yu-Chi Wang, Chi-Cheng Chuang, Kuo-Chen Wei, Cheng-Nen Chang, Shih-Tseng Lee, Chieh-Tsai Wu, Yung-Hsin Hsu, Tzu-Kan Lin, Peng-Wei Hsu, Yin-Cheng Huang, Chen-Kan Tseng, Chun-Chieh Wang, Yao-Liang Chen, Pin-Yuan Chen
Atypical and malignant meningiomas are rare. Our aim was to examine the treatment outcomes following surgical resection, and analyze associations between clinical characteristics and overall survival (OS) or relapse free survival (RFS). 102 patients with atypical or malignant meningiomas underwent microsurgical resection between June 2001 and November 2009 were analyzed retrospectively. We compared demographics, clinical characteristics, treatment, and complications. The five-year and ten-year overall survival rates were 93...
October 20, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27756342/the-relation-between-the-patient-health-questionnaire-15-and-dsm-somatic-diagnoses
#16
Shih-Cheng Liao, Wei-Lieh Huang, Huei-Mei Ma, Min-Tzu Lee, Tzu-Ting Chen, I-Ming Chen, Susan Shur-Fen Gau
BACKGROUND: Our purpose was to examine the reliability and validity of the Chinese version of the Patient Health Questionnaire-15 (PHQ-15) in Taiwan, and to explore its relation to somatoform disorders (DSM-IV) and to somatic symptom and related disorders (DSM-5). METHODS: We recruited 471 individuals, 151 with somatoform disorders and 200 with somatic symptom and related disorders. Subjects completed the Chinese version of the PHQ-15, Beck Depression Inventory-II (BDI-II), Beck Anxiety Inventory (BAI), and received a DSM-IV- and DSM-5-based diagnostic interview...
October 18, 2016: BMC Psychiatry
https://www.readbyqxmd.com/read/27747472/advances-in-laparoscopic-and-robotic-gastrectomy-for-gastric-cancer
#17
Sheng-Han Tsai, Chien-An Liu, Kuo-Hung Huang, Yuan-Tzu Lan, Ming-Huang Chen, Yee Chao, Su-Shun Lo, Anna Fen-Yau Li, Chew-Wun Wu, Shih-Hwa Chiou, Muh-Hwa Yang, Yi-Ming Shyr, Wen-Liang Fang
Robot-assisted gastrectomy has been reported to be a safe alternative to both conventional laparoscopy and the open approach for treating early gastric carcinoma. Currently, there are a limited number of published reports on this technique in the literature. We assessed the current status of robotic and laparoscopic surgery in the treatment of gastric cancer and compared the operative outcomes, learning curves, and oncological outcome of the two approaches. Robotic gastrectomy offers benefits that include increased ease of performing D2 lymph node dissection and reduced blood loss compared with laparoscopic gastrectomy...
October 17, 2016: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/27733774/time-lagging-interplay-effect-and-excess-risk-of-meteorological-mosquito-parameters-and-petrochemical-gas-explosion-on-dengue-incidence
#18
Ko Chang, Chaur-Dong Chen, Chien-Ming Shih, Tzu-Chi Lee, Ming-Tsang Wu, Deng-Chyang Wu, Yen-Hsu Chen, Chih-Hsing Hung, Meng-Chieh Wu, Chun-Chi Huang, Chien-Hung Lee, Chi-Kung Ho
In Kaohsiung, a metropolitan city in Taiwan at high risk of dengue epidemic, weather factors combined with an accidental petrochemical gas explosion (PGE) may affect mosquito‒human dynamics in 2014. Generalized estimating equations with lagged-time Poisson regression analyses were used to evaluate the effect of meteorological/mosquito parameters and PGE on dengue incidences (2000-2014) in Kaohsiung. Increased minimum temperatures rendered a 2- and 3-month lagging interactive effect on higher dengue risks, and higher rainfall exhibited a 1- and 2-month lagging interplay effect on lower risks (interaction, P ≤ 0...
October 13, 2016: Scientific Reports
https://www.readbyqxmd.com/read/27698494/regulation-of-the-abundance-of-kaposi-s-sarcoma-associated-herpesvirus-orf50-protein-by-oncoprotein-mdm2
#19
Tzu-Hsuan Chang, Shie-Shan Wang, Lee-Wen Chen, Ying-Ju Shih, Li-Kwan Chang, Shih-Tung Liu, Pey-Jium Chang
The switch between latency and the lytic cycle of Kaposi's sarcoma-associated herpesvirus (KSHV) is controlled by the expression of virally encoded ORF50 protein. Thus far, the regulatory mechanism underlying the protein stability of ORF50 is unknown. Our earlier studies have demonstrated that a protein abundance regulatory signal (PARS) at the ORF50 C-terminal region modulates its protein abundance. The PARS region consists of PARS-I (aa 490-535) and PARS-II (aa 590-650), and mutations in either component result in abundant expression of ORF50...
October 2016: PLoS Pathogens
https://www.readbyqxmd.com/read/27639528/ultrastrong-trapping-of-vegf-by-graphene-oxide-anti-angiogenesis-application
#20
Pei-Xin Lai, Chung-Wein Chen, Shih-Chun Wei, Tzu-Yu Lin, Hong-Jyuan Jian, Irving Po-Jung Lai, Ju-Yi Mao, Pang-Hung Hsu, Han-Jia Lin, Wen-Shyong Tzou, Shiow-Yi Chen, Scott G Harroun, Jui-Yang Lai, Chih-Ching Huang
Angiogenesis is the process of formation of new blood vessels, which is essential to human biology, and also plays a crucial role in several pathologies such as tumor growth and metastasis, exudative age-related macular degeneration, and ischemia. Vascular endothelial growth factor (VEGF), in particular, VEGF-A165 is the most important pro-angiogenic factor for angiogenesis. Thus, blocking the interaction between VEGFs and their receptors is considered an effective anti-angiogenic strategy. We demonstrate for that first time that bovine serum albumin-capped graphene oxide (BSA-GO) exhibits high stability in physiological saline solution and possesses ultrastrong binding affinity towards VEGF-A165 [dissociation constant (Kd) ∼3 × 10(-12) M], which is at least five orders of magnitude stronger than that of high-abundant plasma proteins such as human serum albumin, fibrinogen, transferrin, and immunoglobulin G...
December 2016: Biomaterials
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