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Mucormycosis

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https://www.readbyqxmd.com/read/29785613/neuroinfections-caused-by-fungi
#1
REVIEW
Katarzyna Góralska, Joanna Blaszkowska, Magdalena Dzikowiec
BACKGROUND: Fungal infections of the central nervous system (FIs-CNS) have become significantly more common over the past 2 decades. Invasion of the CNS largely depends on the immune status of the host and the virulence of the fungal strain. Infections with fungi cause a significant morbidity in immunocompromised hosts, and the involvement of the CNS may lead to fatal consequences. METHODS: One hundred and thirty-five articles on fungal neuroinfection in PubMed, Google Scholar, and Cochrane databases were selected for review using the following search words: "fungi and CNS mycoses", CNS fungal infections", "fungal brain infections", " fungal cerebritis", fungal meningitis", "diagnostics of fungal infections", and "treatment of CNS fungal infections"...
May 21, 2018: Infection
https://www.readbyqxmd.com/read/29773436/non-sinonasal-isolated-facio-orbital-mucormycosis-a-case-report
#2
S K Swain, M C Sahu, A Banerjee
Mucormycosis is a rare clinical entity, often affect immunocompromised patients. It is an emergency situation and has poor prognosis. Prompt diagnosis with tissue biopsy, local control of the disease by aggressive surgical debridement and appropriate systemic antifungal treatment improve the prognosis and survival of the patients. Treatment of mucormycosis needs antifungal agents such as Amphotericin B and wide surgical debridement. Early diagnosis and treatment is often needed for survival of the patients...
May 14, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29771758/opportunistic-fungal-infection-in-children-and-management
#3
Joseph M Lam
PURPOSE OF REVIEW: An opportunistic mycosis is a fungal agent of low pathogenicity that specifically infects immunocompromised hosts. Advances in transplantation, preterm care, immunosuppressive therapies and intensive care, have lead to the emergence of pediatric patients with serious immunodeficiency who are vulnerable to nonpathogenic fungi. RECENT FINDINGS: The advent of the use of biologic agents in pediatric disease as well as the advances in care of preterm and immunosuppressed patients opens up a new cohort of patients at risk of opportunistic mycotic infections...
May 15, 2018: Current Opinion in Pediatrics
https://www.readbyqxmd.com/read/29771293/breakthrough-fungal-infections-in-leukemia-patients-receiving-isavuconazole
#4
Caitlin R Rausch, Adam J DiPippo, Prithviraj Bose, Dimitrios P Kontoyiannis
Isavuconazole (ISA) is increasingly used in leukemia patients. We retrospectively assessed breakthrough invasive fungal infections (b-IFIs) in 100 consecutive leukemia patients receiving ISA as single agent; 13 developed documented b-IFIs. (6 candidiasis, 6 mold infections, 4 mucormycosis). All b-IFIs were observed in patients with prolonged neutropenia and active leukemia.
May 16, 2018: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29769603/components-of-a-new-gene-family-of-ferroxidases-involved-in-virulence-are-functionally-specialized-in-fungal-dimorphism
#5
María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Laura Murcia, Pablo Martínez-García, Carlos Lax, Marta Sanchis, Javier Capilla, Francisco E Nicolás, Victoriano Garre
Mucormycosis is an emerging angio-invasive infection caused by Mucorales that presents unacceptable mortality rates. Iron uptake has been related to mucormycosis, since serum iron availability predisposes the host to suffer this infection. In addition, iron uptake has been described as a limiting factor that determines virulence in other fungal infections, becoming a promising field to study virulence in Mucorales. Here, we identified a gene family of three ferroxidases in Mucor circinelloides, fet3a, fet3b and fet3c, which are overexpressed during infection in a mouse model for mucormycosis, and their expression in vitro is regulated by the availability of iron in the culture media and the dimorphic state...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29768642/-rhinocerebral-mucormycosis
#6
Anke Mertens, Christoph Arens, Doreen Barche, Laszlo Scheinpflug, Friedrich Gunther Scholz, Stefan Vielhaber, Cordula Scherlach, Uwe Tröger, Gernot Geginat, Jacqueline Färber
Mucormycosis is a rare but serious type of fungal infection, which can progress rapidly especially in immunsupressed patients.We report about a 47 year old female patient with ptosis on the left eye. The ophthalmological report offered no further pathologic findings. Diabetes mellitus was known and the blood sugar value was very high.A computed tomography of the paranasal sinuses showed a shadow in the ethmoid bone and in an additonally performed MRI-scan, an increase of orbital fat and an extension of the ocular muscle were visible...
May 16, 2018: Laryngo- Rhino- Otologie
https://www.readbyqxmd.com/read/29760835/cutaneous-mucormycosis-following-a-bullous-pemphigoid-flare-in-a-chronic-lymphocytic-leukemia-patient-on-ibrutinib
#7
Matthew K Stein, Saradasri Karri, Jackson Reynolds, Jeff Owsley, Austin Wise, Mike G Martin, Fereshteh Zare
While the recent development of novel therapeutics in oncology, such as small molecule kinase inhibitors (SMKIs), has enabled our ability to target disease-specific molecular pathways, the prolonged impact of these agents on the immune system and infectious risk remains to be seen. We present a 68-year-old male with refractory chronic lymphocytic leukemia (CLL) on ibrutinib monotherapy for 3 years who developed extensive cutaneous mucormycosis following a severe bullous pemphigoid (BP) flare. He received amphotericin B for 4 weeks and was continued on posaconazole with resolution of his mucormycosis infection...
April 2018: World Journal of Oncology
https://www.readbyqxmd.com/read/29754839/-retrospective-study-of-25-cases-of-pulmonary-mucormycosis-in-acute-leukaemia
#8
REVIEW
D Caillot, C Legouge, I Lafon, E Ferrant, P B Pagès, A Plocque, L Estivalet, S Valot, F Dalle, H Abou Hanna, M-L Chretien
INTRODUCTION: In acute leukaemia (AL), the occurrence of pulmonary mucormycosis (PM), the incidence of which is increasing, as a result of chemotherapy induced marrow aplasia, remains a life threatening complication. METHODS: Analysis of clinical, biological and thoracic CT characteristics of patients with PM developing during the treatment of AL between 2000 and 2015. Day 0 (D0) was defined as the day with first CT evidence of PM. RESULTS: Among 1193 patients, 25 cases of PM were recorded during 2099 episodes of bone marrow aplasia...
May 10, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29750016/spotlight-on-isavuconazole-in-the-treatment-of-invasive-aspergillosis-and-mucormycosis-design-development-and-place-in-therapy
#9
REVIEW
Jeffrey D Jenks, Helmut Jf Salzer, Juergen Prattes, Robert Krause, Dieter Buchheidt, Martin Hoenigl
In recent decades, important advances have been made in the diagnosis and treatment of invasive aspergillosis (IA) and mucormycosis. One of these advances has been the introduction of isavuconazole, a second-generation broad spectrum triazole with a favorable pharmacokinetic and safety profile and few drug-drug interactions. Phase III trials in patients with IA and mucormycosis demonstrated that isavuconazole has similar efficacy to voriconazole for the treatment of IA (SECURE trial) and liposomal amphotericin B for the treatment of mucormycosis (VITAL trial with subsequent case-control analysis) and a favorable safety profile with significantly fewer ocular, hepatobiliary, and skin and soft tissue adverse events compared to voriconazole...
2018: Drug Design, Development and Therapy
https://www.readbyqxmd.com/read/29748841/characteristics-of-pulmonary-mucormycosis-and-predictive-risk-factors-for-the-outcome
#10
Jun Feng, Xuefeng Sun
PURPOSE: Little is known about risk factors for the outcome of pulmonary mucormycosis. We summarized characteristics of this rare disease, and systemically explored risk factors for the outcome. METHODS: Ninety-two patients with pulmonary mucormycosis, including 12 patients at Peking Union Medical College Hospital and 80 patients published in 62 articles between 2006 and 2016, were retrospectively analyzed. RESULTS: The median age was 47.5 years, and the male to female ratio was 2...
May 10, 2018: Infection
https://www.readbyqxmd.com/read/29744327/management-of-recurrent-rhinomaxillary-mucormycosis-and-nasal-myiasis-in-an-uncontrolled-diabetic-patient-a-systematic-approach
#11
N M Manjunath, Preema Melani Pinto
Mucormycosis is a rare but often fatal fungal infection caused by a group of fungus known as the Mucorales. This fungus can cause varieties of infections in human beings, especially in an immunocompromised condition. According to various studies, the mortality rate ranges from 10% to 100% depending on the location and site of infection accompanied by underlying diseases. Rhinomaxillary involvement is the most common form of mucormycosis predominantly occurring in patients with uncontrolled diabetes. Necrosis of the maxilla in patients with rhinomaxillary form is less evident as the maxilla is richly vascular, but in case of immunocompromised status, it becomes a common clinical finding...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29725999/clinical-pharmacokinetics-and-pharmacodynamics-of-isavuconazole
#12
REVIEW
Matthew W McCarthy, Brad Moriyama, Ruta Petraitiene, Thomas J Walsh, Vidmantas Petraitis
In March 2015, the extended-spectrum triazole antifungal isavuconazole was granted approval by the US Food and Drug Administration and the European Medicines Agency for the treatment of invasive aspergillosis and mucormycosis. Isavuconaozle has activity against a broad range of yeasts, dimorphic fungi, and molds and is associated with fewer toxicities than voriconazole. It also has predictable pharmacokinetics in adults, fewer drug-drug interactions than many existing antifungal agents, and is available in both oral and β-cyclodextrin-free intravenous formulations...
May 4, 2018: Clinical Pharmacokinetics
https://www.readbyqxmd.com/read/29724988/total-gastric-necrosis-due-to-mucormycosis-a-rare-case-of-gastric-perforation
#13
Salah Termos, Feras Othman, Mohammad Alali, Bader M S Al Bader, Talal Alkhadher, Wael Fathi Hassanaiah, Ali Taqi, Abhijit Sapkal
BACKGROUND Spontaneous gastric perforation is usually a complication of peptic ulcer disease, or a postoperative complication resulting from gastric torsion. Mucormycosis (or zygomycosis) is an uncommon opportunistic fungal infection that is usually seen in immunocompromised patients and is associated with significant morbidity and mortality. This report is of a rare case of spontaneous gastric perforation due to mucormycosis infection. CASE REPORT A 52-year-old woman, with a past medical history of heroin abuse, diabetes mellitus, hypertension, and chronic kidney disease treated by dialysis, presented to the emergency department with cellulitis of the arms...
May 4, 2018: American Journal of Case Reports
https://www.readbyqxmd.com/read/29721234/mucormycosis-of-maxilla-following-tooth-extraction-in-immunocompetent-patients-reports-and-review
#14
Kumar Nilesh, Aaditee V Vande
Mucormycosis is a rare, fulminant, rapidly spreading fungal infection, which usually affects patient with underlying immune deficiency. If not managed promptly, the disease is characterized by progressive necrosis and is often fatal. A review of English literature shows that only fourteen cases of mucormycosis have been reported after tooth extraction. This paper highlights two cases of mucormycosis subsequent to tooth extraction in healthy adult patients. This first patient presented with an oroantral fistula and extensive maxillary necrosis...
March 2018: Journal of Clinical and Experimental Dentistry
https://www.readbyqxmd.com/read/29712993/development-of-a-quantitative-pcr-detecting-cunninghamella-bertholletiae-to-help-in-diagnosing-this-rare-and-aggressive-mucormycosis
#15
Anne-Pauline Bellanger, Ana Berceanu, Steffi Rocchi, Benoit Valot, Jean Fontan, Adrien Chauchet, Nicolas Belin, Emeline Scherer, Eric Deconinck, Jean-Christophe Navellou, Laurence Millon
Mucormycosis is an invasive mold infection, frequently fatal in immunocompromised patients. We report the case of a patient with chronic lymphocytic leukemia admitted to the hematology unit for febrile aplasia. Pulmonary lesions suggesting a fungal infection expanded/increased despite a combination of posaconazole and liposomal amphotericin B. The fungal biomarkers performed repeatedly were negative. At D65 after chemotherapy a bronchial biopsy was positive for Cunninghamella bertholletiae. The patient died despite appropriate antifungal management...
April 30, 2018: Bone Marrow Transplantation
https://www.readbyqxmd.com/read/29707367/urokinase-application-for-hemothorax-in-pulmonary-mucormycosis
#16
Lucas Hodel, Ilhan Inci, Urs Schanz, Bart Vrugt, Walter Weder, Sven Hillinger
We present an exemplary case of an immunocompromised patient with pulmonary mucormycosis successfully treated by a combination of surgical removal of the mucor and urokinase to control the recurring hemothorax. The use of urokinase in hemothoraces is a way to reduce repetitive surgeries in weak patients.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29691339/outbreak-of-invasive-wound-mucormycosis-in-a-burn-unit-due-to-multiple-strains-of-mucor-circinelloides-f-circinelloides-resolved-by-whole-genome-sequencing
#17
Dea Garcia-Hermoso, Alexis Criscuolo, Soo Chan Lee, Matthieu Legrand, Marc Chaouat, Blandine Denis, Matthieu Lafaurie, Martine Rouveau, Charles Soler, Jean-Vivien Schaal, Maurice Mimoun, Alexandre Mebazaa, Joseph Heitman, Françoise Dromer, Sylvain Brisse, Stéphane Bretagne, Alexandre Alanio
Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015)...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29672274/cutaneous-mucormycosis-as-a-presenting-feature-of-type-1-diabetes-in-a-boy-case-report-and-review-of-the-literature
#18
Ganesh Jevalikar, Siddhnath Sudhanshu, Sanjay Mahendru, Smita Sarma, Khalid J Farooqui, Ambrish Mithal
BACKGROUND: Mucormycosis is a potentially fatal complication of diabetes. The rhino-orbito-cerebral form is the most common presentation, however, rarely other types can also be seen. CASE PRESENTATION: We describe the case of a 4½ -year-old boy not previously known to be a diabetic who presented to the plastic surgery department for gangrene of the left middle finger with surrounding erythema and induration. After the diagnosis of diabetes and initial treatment, pus from the wound showed broad aseptate hyphae suggestive of mucormycosis which was further confirmed on culture...
April 19, 2018: Journal of Pediatric Endocrinology & Metabolism: JPEM
https://www.readbyqxmd.com/read/29670779/pulmonary-mucormycosis-in-chronic-lymphocytic-leukemia-and-neutropenia
#19
Izza Mir, Sijan Basnet, David Ellsworth, Elan Mohanty
Pulmonary mucormycosis is a rare life-threatening fungal infection associated with high mortality. We present the case of a 61-year-old man with history of chronic lymphocytic leukemia who presented with fever and cough, eventually diagnosed with pulmonary mucormycosis after right lung video-assisted thoracoscopic surgery. The patient was successfully treated with amphotericin B and right lung pneumonectomy; however, he later died from left lung pneumonia.
2018: Case Reports in Infectious Diseases
https://www.readbyqxmd.com/read/29668130/-rhino-orbito-cerebral-mucormycosis-from-dental-origin-case-report
#20
José Humberto Bravo, Andrés Mauricio Agudelo, Armando Cortés, Lorena Matta
Rhino-orbito-cerebral mucormycosis from dental origin is an acute infection caused by opportunistic fungi belonging to the order of Mucorales, which affects mainly diabetic and immunocompromised patients.We report the case of a 63-year old diabetic man who performed a dental extraction on himself by his own means and subsequently developed a rhino-orbito-cerebral mucormycosis with cutaneous and palatal affection. The species isolated in the mycological culture was Rhizopus sp.
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
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