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Mucormycosis

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https://www.readbyqxmd.com/read/27923750/the-affinity-of-mucormycosis-for-the-basal-ganglia-in-intravenous-drug-users-a-case-illustration-and-review-of-the-literature
#1
Ali Hazama, Michael Galgano, Joseph Fullmer, Walter Hall, Lawrence Chin
Central nervous system mucormycosis is an aggressive fungal infection often ending in fatality. The usual circumstance is an immunocompromised individual presenting with rapidly progressive rhinocerebral involvement. An extremely rare variant of central nervous system mucormycosis isolated to the basal ganglia in an immunocompetent intravenous drug user is detailed in this manuscript. The patient was aggressively treated with aspiration of the fungal abscess and long-term intravenous antifungal agents.
December 3, 2016: World Neurosurgery
https://www.readbyqxmd.com/read/27905900/prevalence-clinical-and-economic-burden-of-mucormycosis-related-hospitalizations-in-the-united-states-a-retrospective-study
#2
Dimitrios P Kontoyiannis, Hongbo Yang, Jinlin Song, Sneha S Kelkar, Xi Yang, Nkechi Azie, Rachel Harrington, Alan Fan, Edward Lee, James R Spalding
BACKGROUND: Mucormycosis is a rare but devastating fungal infection primarily affecting immunocompromised patients such as those with hematological malignancy, bone marrow and solid organ transplantation, and patients with diabetes, and, even more rarely, immunocompetent patients. The objective of this study was to assess the prevalence and burden, both clinical and economic, of mucormycosis among hospitalized patients in the U.S. METHODS: This is a retrospective study using the Premier Perspective(TM) Comparative Database, with more than 560 participating hospitals covering 104 million patients (January 2005-June 2014)...
December 1, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27904061/diagnosis-and-treatment-of-mucormycosis-in-patients-with-hematological-malignancies
#3
Yuki Asano-Mori
The risk of invasive fungal infections (IFIs) is extremely high in patients with hematological malignancies due to the prolonged and profound neutropenia and immunosuppression after chemotherapy and hematopoietic stem cell transplantation. There has been increasing interest in mucormycosis despite its relatively uncommon occurrence, because occasional breakthrough infections have been observed under anti-aspergillus prophylaxis. The aggressive nature of mucormycosis easily leads to high mortality because of delays in diagnosis and incorrect treatment decisions, which are due in part to lack of adjunctive diagnostic tools and having similar clinical and radiological features with aspergillosis...
2016: Medical Mycology Journal
https://www.readbyqxmd.com/read/27902424/clinical-evaluation-of-mucorales-specific-real-time-pcr-assay-in-tissue-and-serum-samples
#4
Jan Springer, Michaela Lackner, Christian Ensinger, Brigitte Risslegger, Charles Oliver Morton, David Nachbaur, Cornelia Lass-Flörl, Hermann Einsele, Werner J Heinz, Juergen Loeffler
Molecular diagnostic assays can accelerate the diagnosis of fungal infections and subsequently improve patient outcomes. In particular, the detection of infections due to Mucorales is still challenging for laboratories and physicians. The aim of this study was to evaluate a probe-based Mucorales-specific real-time PCR assay (Muc18S) using tissue and serum samples from patients suffering from invasive mucormycosis (IMM). This assay can detect a broad range of clinically relevant Mucorales species and can be used to complement existing diagnostic tests or to screen high-risk patients...
October 24, 2016: Journal of Medical Microbiology
https://www.readbyqxmd.com/read/27900242/management-of-rhinomaxillary-mucormycosis-with-posaconazole-in-immunocompetent-patients
#5
Sachin Rai, Shikha Yadav, Dinesh Kumar, Vijay Kumar, Vidya Rattan
Mucormycosis is an opportunistic, uncommon and serious systemic fungal infection mostly presenting in immunocompromised patients. The combination of surgical debridement, parenteral therapy with Amphotericin B and management of the underlying systemic disease is the standard treatment modality for mucormycosis. The drawback of this regime is the need for long hospitalization due to the serious side effects of Amphotericin B requiring regular monitoring. Oral Posaconazole is one of the newer antifungals that have shown promising results...
November 2016: Journal of Oral Biology and Craniofacial Research
https://www.readbyqxmd.com/read/27900065/rhino-orbital-cerebral-mucormycosis-and-orbital-exenteration
#6
Matthew P Fahrenkopf, Joshua J Nelson, Mitchell Eichhorn, Julie Conway, Adam Hassan
No abstract text is available yet for this article.
2016: Eplasty
https://www.readbyqxmd.com/read/27887809/an-estimation-of-burden-of-serious-fungal-infections-in-france
#7
J-P Gangneux, M-E Bougnoux, C Hennequin, C Godet, J Chandenier, D W Denning, B Dupont
OBJECTIVE OF THE STUDY: An estimation of burden of serious fungal diseases in France is essential data to inform public health priorities on the importance of resources and research needed on these infections. In France, precise data are available for invasive fungal diseases but estimates for several other diseases such as chronic and immunoallergic diseases are by contrast less known. MATERIALS AND METHODS: A systematic literature search was conducted using the Web of Science Platform...
November 22, 2016: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/27886415/primary-mucormycosis-of-the-breast-a-rare-entity
#8
Veenu Singla, Nidhi Prabhakar, Tulika Singh, Niranjan Khandelwal, Gurpreet Singh, Rakesh Vasishta
No abstract text is available yet for this article.
November 25, 2016: Breast Journal
https://www.readbyqxmd.com/read/27880667/the-current-treatment-landscape-other-fungal-diseases-cryptococcosis-fusariosis-and-mucormycosis
#9
Olivier Lortholary, Mario Fernández-Ruiz, John R Perfect
Compared with major invasive mycoses such as aspergillosis and candidiasis, the antifungal stewardship management strategies of other fungal diseases have different opportunities and considerations. Cryptococcosis, fusariosis and mucormycosis are globally prevalent invasive fungal diseases (IFDs), but are not currently included in antifungal prophylaxis guidelines for immunocompromised hosts. Since the implementation of biomarkers as part of diagnostic screening strategies, the concept of pre-emptive antifungal therapy has emerged for these IFDs...
November 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27875707/mucormycosis-causing-ludwig-angina-a-unique-presentation
#10
Ryan P McSpadden, James R Martin, Swati Mehrotra, Eric Thorpe
Mucormycosis is a rare fungal infection with a yearly incidence of 1.7 cases per million in the United States. It often occurs in patients with metabolic abnormalities or immunocompromised patients with prolonged neutropenia but can occur in patients without any underlying disease process. The treatment of choice is surgical debridement of necrotic tissue and systemic antifungal therapy, including amphotericin B. A dilemma for the surgeon when faced with head and neck mucormycosis is the morbidity of surgical debridement from a functional and cosmetic standpoint...
October 29, 2016: Journal of Oral and Maxillofacial Surgery
https://www.readbyqxmd.com/read/27875508/extensive-oral-mucormycosis-in-a-transplanted-patient
#11
Bernar Monteiro Benites, Felipe Paiva Fonseca, Claudia Joffily Parahyba, Sergio Samir Arap, Yana Augusta Novis, Eduardo Rodrigues Fregnani
Mucormycosis is an invasive fungal disease caused by fungi from the Mucorales order that are found in the soil and decaying organic debris. Mucormycosis has been reported to be the third most common fungal disease in stem cell transplanted patients. The fungi have a tendency for vascular invasion, resulting in thrombi development, which decreases blood supply and leads to extensive tissue necrosis. Here, the authors present a patient of mucormycosis affecting the soft palate, oropharynx, and hypopharynx in a type II diabetic male patient who underwent allogeneic stem cell transplantation, and the authors further review the literature on oral mucormycosis for the last 10 years...
November 21, 2016: Journal of Craniofacial Surgery
https://www.readbyqxmd.com/read/27861475/-rhino-orbital-mucormycosis-cohort-study-of-its-treatment-according-disease-extent-and-reversion-of-its-pathophysiology
#12
Héctor Manuel Prado-Calleros, Germán Fajardo-Dolci, Olga Plowes-Hernández, Carlos Jiménez-Gutiérrez
Mucormycosis is a lethal opportunistic fungal infection, described mostly in immunocompromised patients. A comparative cohort study was conducted to compare the evolution of the study group patients with rhino-orbital mucormycosis, in which a therapeutic protocol was instituted, in which the pterygomaxillary fossa is systematically surgically approached and orbital exenteration is performed or not based on the spreading of the infection to the orbital apex or the orbital fissure, with a historical group where these criteria were not applied...
November 2016: Gaceta Médica de México
https://www.readbyqxmd.com/read/27856701/40-years-of-medical-mycology-at-jac
#13
REVIEW
Luis Ostrosky-Zeichner
In the past 40 years, medical mycology has gone from a curiosity in the basements of medical schools to a mainstream branch of clinical microbiology and infectious diseases. Long gone are the days of carefully curated collections of organisms identified purely based on morphology and skill, the lack of therapeutic interventions beyond amphotericin B and the occasional strange case in the ward of a diabetic patient with mucormycosis. We highlight advances in medical mycology as reflected in the past 40 years of JAC...
December 2016: Journal of Antimicrobial Chemotherapy
https://www.readbyqxmd.com/read/27851396/1761-invasive-mucormycosis-treated-with-dual-intravenous-nebulized-antifungal-therapy-in-a-burn-patient
#14
Asia Quan, James Sanders, Christelle Kassis, Thomas Ardiles, Daniel Caruso, Kevin Foster
No abstract text is available yet for this article.
December 2016: Critical Care Medicine
https://www.readbyqxmd.com/read/27845850/ct-guided-percutaneous-lung-biopsies-in-patients-with-suspicion-for-infection-may-yield-clinically-useful-information
#15
Brian M Haas, Joshua D Clayton, Brett M Elicker, Karen G Ordovas, David M Naeger
OBJECTIVE: The objective of our study was to assess the frequency and time frame with which CT-guided lung biopsies for suspected infection yield information that can affect patient management. MATERIALS AND METHODS: All CT-guided lung biopsies over a 68-month period performed for the purpose of diagnosing a suspected infection were reviewed to determine the proportion that yielded information affecting patient management. Patients were included if infection was the only consideration causing the pulmonary lesion in question...
November 15, 2016: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/27832748/invasive-mucormycosis-in-children-an-epidemiologic-study-in-european-and-non-european-countries-based-on-two-registries
#16
Zoi Dorothea Pana, Danila Seidel, Anna Skiada, Andreas H Groll, Georgios Petrikkos, Oliver A Cornely, Emmanuel Roilides
BACKGROUND: Mucormycosis has emerged as a rare but frequently fatal invasive fungal disease. Current knowledge on paediatric mucormycosis is based on case reports and small series reported over several decades. Contemporary data on a large cohort of patients is lacking. METHODS: Two large international registries (Zygomyco.net and FungiScope™) were searched for mucormycosis cases in ≤19 year-old patients. Cases enrolled between 2005 and 2014 were extracted, and dual entries in the two databases merged...
November 10, 2016: BMC Infectious Diseases
https://www.readbyqxmd.com/read/27822198/looks-like-tuberculous-meningitis-but-not-a-case-of-rhinocerebral-mucormycosis-with-garcin-syndrome
#17
HongNa Yang, CuiLan Wang
Rhinocerebral mucomycosis (RCM) as an emerging opportunistic, angioinvasive, and devastating fungi infection with high mortality is difficult to be diagnosed early because of the lack of specific clinical features or manifestations. Garcin syndrome is more often caused by skull base and rhinopharyngeal tumors or metastases, and basal meningitis. We reported that an aged diabetic man, involved nearly all cranial nerves (Garcin syndrome), who was at first suspected to be suffered from tuberculous meningitis, ultimately developed typically progressing RCM...
2016: Frontiers in Neurology
https://www.readbyqxmd.com/read/27807669/primary-cutaneous-mucormycosis-caused-by-rhizopus-oryzae-a-case-report-and-review-of-literature
#18
Erika Rodríguez-Lobato, Lourdes Ramírez-Hobak, Jorge E Aquino-Matus, Juan P Ramírez-Hinojosa, Víctor H Lozano-Fernández, Juan Xicohtencatl-Cortes, Rigoberto Hernández-Castro, Roberto Arenas
Mucormycosis is an invasive infection caused by opportunistic fungi. Rhizopus, Lichtheimia, Mucor and Rhizomucor are the most common isolated genera. Primary cutaneous mucormycosis is usually related to traumatic injuries, but immunocompromised cases are associated with underlying conditions such as diabetes mellitus and malignancies. The treatment of choice is surgical debridement and liposomal amphotericin B. We present a 40-year-old male with fever and a painful necrotic lesion on the middle back and history of poorly controlled diabetes mellitus...
November 3, 2016: Mycopathologia
https://www.readbyqxmd.com/read/27807051/acute-myocardial-infarction-in-disseminated-mucormycosis-infection
#19
David Ferreira, Allan Davies, Thyaparan Thiruchelvam, Peter Wark
No abstract text is available yet for this article.
November 2, 2016: European Heart Journal
https://www.readbyqxmd.com/read/27798213/monotherapy-or-combination-therapy-of-isavuconazole-and-micafungin-for-treating-murine-mucormycosis
#20
Teclegiorgis Gebremariam, Nathan P Wiederhold, Abdullah Alqarihi, Priya Uppuluri, Nkechi Azie, John E Edwards, Ashraf S Ibrahim
OBJECTIVES: Previously we demonstrated the benefit of isavuconazole in treating murine mucormycosis due to Rhizopus. We wanted to determine the efficacy of isavuconazole in treating murine mucormycosis caused by Mucor, the second most common cause of the disease. Furthermore, because we previously determined that Rhizopus possesses the target enzyme for echinocandins and micafungin has activity against murine mucormycosis, we compared the activity of combination therapy (isavuconazole + micafungin) with placebo, either drug alone or standard therapy of liposomal amphotericin B (LAmB) in treating pulmonary murine mucormycosis caused by Rhizopus delemar...
October 24, 2016: Journal of Antimicrobial Chemotherapy
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