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Mucormycosis

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https://www.readbyqxmd.com/read/29327534/gastric-angioinvasive-mucormycosis-in-immunocompetent-adult-a-rare-occurrence
#1
Mukesh Nasa, Zubin Sharma, Lipika Lipi, Randhir Sud
Mucormycosis is a rare, opportunistic fungal infection that occurs almost exclusively in immunocompromised hosts such as patients with diabetes mellitus, leukemia, lymphoma, renal disease, septicemia, burns, malnutrition, and following long-term treatment with steroids and antibiotics. Based on the clinical presentation and involvement, mucormycosis is classified as six major forms, namely, rhinocerebral, pulmonary, cutaneous, gastrointestinal (GI), disseminated and miscellaneous, with rhinocerebral and pulmonary being the common forms...
December 2017: Journal of the Association of Physicians of India
https://www.readbyqxmd.com/read/29326525/mucormycosis-in-a-diabetic-patient-a-case-report-with-an-insight-into-its-pathophysiology
#2
Syeda Neelam Afroze, Rajani Korlepara, Guttikonda Venkateswara Rao, Jayakiran Madala
Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infection which usually begins in the nose and paranasal sinuses following inhalation of fungal spores. It is caused by organisms of the subphylum Mucormycotina, including genera as Absidia, Mucor, Rhizomucor, and Rhizopus. The incidence of mucormycosis is approximately 1.7 cases per 1,000,000 inhabitants per year. Mucormycosis affecting the maxilla is rare because of rich blood vessel supply of maxillofacial areas although more virulent fungi such as Mucor can overcome this difficulty...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29326340/rare-cause-of-pulmonary-cavitation-in-a-75-year-old-man
#3
Jaffar Al-Sheikhli, Hussein Taqi, John Drake, Ayaaz Habib
A 75-year-old man of Asian descent presented to the acute medical unit with signs and symptoms suggestive of a community-acquired pneumonia. He had multiple comorbidities and was relatively immunocompromised as a result. Initial investigations supported the diagnosis of community-acquired pneumonia complicated by a cavitating lung lesion, and the patient was treated as per hospital guidelines. He continued to deteriorate despite appropriate therapy and developed a hydropneumothorax, requiring the insertion of a chest drain...
January 10, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29319040/refractory-bronchovascular-pleuropulmonary-mucormycosis-case-report-and-difficulties-in-management
#4
M Manjunath, Deepak Prajapat, Rahul Kumar Sharma, Deepak Talwar
Pulmonary mucormycosis is a life-threatening opportunistic fungal infection. It is considered as a disease of immunocompromised state and is rarely seen in immunocompetent patients. We here report a case of refractory bronchovascular pleuropulmonary mucormycosis, who despite early detection, optimal management with liposomal amphotericin B, and posaconazole therapy followed by surgery, progressed further and led to a fatal outcome. Dual antifungal therapy combined with surgery is the only definitive treatment option available in the literature...
January 2018: Lung India: Official Organ of Indian Chest Society
https://www.readbyqxmd.com/read/29302152/spinal-mucormycosis
#5
Kunal Shah, Abhay Nene
Spinal mucormycosis is a rare and fatal condition. High degree of suspicion is required for early diagnosis and treatment.
October 2017: Journal of Global Infectious Diseases
https://www.readbyqxmd.com/read/29297721/mucor-circinelloides-induces-platelet-aggregation-through-integrin-%C3%AE-iib%C3%AE-3-and-fc%C3%AE-riia
#6
Harlene Ghuman, Alicia Shepherd-Roberts, Stephanie Watson, Malou Zuidscherwoude, Steve P Watson, Kerstin Voelz
Thrombosis is a hallmark of the fatal fungal infection mucormycosis. Yet, the platelet activation pathway in response to mucormycetes is unknown. In this study we determined the platelet aggregation potential of Mucor circinelloides (M. circinelloides) NRRL3631, characterized the signaling pathway facilitating aggregation in response to fungal spores, and identified the influence of the spore developmental stage upon platelet aggregation potential. Using impedance and light-transmission aggregometry, we showed that M...
January 3, 2018: Platelets
https://www.readbyqxmd.com/read/29282189/cutaneous-mucormycosis-a-fatal-complication-of-immunosuppressant-therapy-for-pemphigus-vulgaris
#7
Kanika Sahni, Dipankar De, Sunil Dogra, Amrinderjit Kanwar, Uma Nahar Saikia
A 62-year-old man with no comorbidities presented to the outpatient department of our Institute with a history of extensive vesiculobullous and erosive skin lesions and oral erosions for 2 months and fever for 1 week. A diagnosis of pemphigus vulgaris was made based on histopathology and direct immunofluorescence of a skin biopsy specimen, and the patient was started on oral prednisolone 40 mg per day along with intravenous antibiotics (amoxicillin-clavulanic acid, gentamicin, and metronidazole) empirically, pending blood and skin swab culture and sensitivity reports...
2017: Skinmed
https://www.readbyqxmd.com/read/29261103/calli-essential-oils-synergize-with-lawsone-against-multidrug-resistant-pathogens
#8
Sameh S M Soliman, Abrar I Alsaadi, Eman G Youssef, Gregory Khitrov, Ayman M Noreddin, Mohamed I Husseiny, Ashraf S Ibrahim
The fast development of multi-drug resistant (MDR) organisms increasingly threatens global health and well-being. Plant natural products have been known for centuries as alternative medicines that can possess pharmacological characteristics, including antimicrobial activities. The antimicrobial activities of essential oil (Calli oil) extracted from the Calligonum comosum plant by hydro-steam distillation was tested either alone or when combined with lawsone, a henna plant naphthoquinone, against MDR microbes...
December 20, 2017: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://www.readbyqxmd.com/read/29259862/disseminated-mucormycosis-a-sinister-cause-of-neutropenic-fever-syndrome
#9
Ghazal Tansir, Neha Rastogi, Prashant Ramteke, Prabhat Kumar, Manish Soneja, Ashutosh Biswas, Sanchit Kumar, Pankaj Jorwal, Upendra Baitha
A 15 year old girl presented with complaints of prolonged fever and recurrent episodes of hemoptysis. Initial investigation showed pancytopenia and radiological imaging was suggestive of necrotizing pneumonia. Subsequently, mucor was isolated from bronchoalveolar lavage fluid, but even on appropriate medications her condition kept deteriorating. She had multiple bouts of hemoptysis and a repeat imaging of chest showed dissemination of mucormycosis to pulmonary vein and heart. Bone marrow biopsy identified acute lymphoblastic leukemia (ALL) as the cause of pancytopenia...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29238686/mutilating-lesions-of-face
#10
Kavita Sachdeva, Aparaajita Upadhyay
The destructive lesions affect midline facial areas causing extensive destruction. These lesions are challenging till date due to peculiarity in presentation and non availability of any single objective test. An attempt has been done to evaluate these different clinical presentations of lesions presenting at a single centre and the challenges faced by us at a tertiary government setup. Prospective study done on 15 patients presenting in department during period of 2006-2016. After a detailed history, hematological and biochemical markers, ESR, radiographical tests, pus culture, C ANCA, CECT PNS and histopathogical evaluation were done...
December 2017: Indian Journal of Otolaryngology and Head and Neck Surgery
https://www.readbyqxmd.com/read/29225797/seasonal-clustering-of-sinopulmonary-mucormycosis-in-patients-with-hematologic-malignancies-at-a-large-comprehensive-cancer-center
#11
Shobini Sivagnanam, Dhruba J Sengupta, Daniel Hoogestraat, Rupali Jain, Zach Stednick, David N Fredricks, Paul Hendrie, Estella Whimbey, Sara T Podczervinski, Elizabeth M Krantz, Jeffrey S Duchin, Steven A Pergam
Background: Invasive Mucorales infections (IMI) lead to significant morbidity and mortality in immunocompromised hosts. The role of season and climatic conditions in case clustering of IMI remain poorly understood. Methods: Following detection of a cluster of sinopulmonary IMIs in patients with hematologic malignancies, we reviewed center-based medical records of all patients with IMIs and other invasive fungal infections (IFIs) between January of 2012 and August of 2015 to assess for case clustering in relation to seasonality...
2017: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/29217228/primary-cutaneous-mucormycosis-due-to-rhizopus-arrhizus-in-an-8-year-old-girl
#12
M F Albízuri-Prado, A Sánchez-Orta, A Rodríguez-Bandera, M Feito-Rodríguez
No abstract text is available yet for this article.
December 4, 2017: Actas Dermo-sifiliográficas
https://www.readbyqxmd.com/read/29200154/rhinocerebral-mucormycosis-with-temporal-artery-thrombosis-in-an-adolescent-following-hla-haploidentical-stem-cell-transplantation
#13
Yuta Kawahara, Shoya Wada, Hitomi Nijima, Tomomi Hayase, Rieko Furukawa, Kentaro Ashizawa, Akira Morimoto
Rhinocerebral mucormycosis (RCM) can lead to internal carotid artery thrombosis. Here, we report the first case of RCM with temporal artery thrombosis following HLA-haploidentical stem cell transplantation in an adolescent presenting with low-grade fever, right mandibular pain, and right jaw claudication. This case suggests that RCM can cause temporal artery thrombosis and should be considered as a differential diagnosis in severely immunocompromised patients with maxillary sinusitis presenting with jaw claudication...
December 1, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29190812/diagnostic-performance-of-the-1-3-%C3%AE-d-glucan-assay-in-patients-with-pneumocystis-jirovecii-compared-with-those-with-candidiasis-aspergillosis-mucormycosis-and-tuberculosis-and-healthy-volunteers
#14
Hyo-Ju Son, Heungsup Sung, Se Yoon Park, Taeeun Kim, Hyun Jeong Lee, Sun-Mi Kim, Yong Pil Chong, Sang-Oh Lee, Sang-Ho Choi, Yang Soo Kim, Jun Hee Woo, Sung-Han Kim
BACKGROUND: Diagnosis of pneumocystis pneumonia (PCP) relies on microscopic visualization of P. jirovecii, or detection of Pneumocystis DNA in respiratory specimens, which involves invasive procedures such as bronchoalveolar lavage. The (1-3)-β-D-glucan (BG) assay has been proposed as a less invasive and less expensive diagnostic test to rule out PCP. We therefore compared blood levels of BG in patients with PCP with those of patients with candidemia, chronic disseminated candidiasis (CDC), invasive aspergillosis, mucormycosis, and tuberculosis and those of healthy volunteers...
2017: PloS One
https://www.readbyqxmd.com/read/29189615/multi-modal-treatment-of-rhinocerebral-mucormycosis-in-a-pediatric-patient-with-relapsed-pre-b-acute-lymphoblastic-leukemia
#15
Zephyr D Dworsky, John S Bradley, Matthew T Brigger, Alice L Pong, Dennis John Kuo
A 17-year-old female developed invasive rhinocerebral mucormycosis during intensive re-induction chemotherapy for relapsed pre-B acute lymphoblastic leukemia. Due to the high case fatality rate for invasive mucormycosis in profoundly immunosuppressed patients, an aggressive treatment regimen was pursued. In addition to the standard of care treatments with intravenous amphotericin and aggressive surgical debridements, she received intraventricular amphotericin to the brain via an Ommaya reservoir, hyperbaric oxygen treatments, filgrastim, intravenous immunoglobulin and anti-fungal in vitro synergy testing to allow for more targeted antifungal therapy with the addition of micafungin...
November 16, 2017: Pediatric Infectious Disease Journal
https://www.readbyqxmd.com/read/29188178/tumor-shape-pulmonary-mucormycosis-associated-with-sinonasal-aspergillosis-in-a-diabetic-patient
#16
Sophie Point, Frédéric Gabriel, Hugues Bégueret, Jacques Jougon, Fanny Lanternier, Frédéric Grenouillet, Manal Abdel Fattah, Emilie Catherinot, Chantal Raherison, Elodie Blanchard
Mucormycosis is a rare and life-threatening fungal infection of the Mucorales order occurring mainly in immunosuppressed patients. The most common forms are rhinocerebral but pulmonary or disseminated forms may occur. We report the case of a 61-year-old patient in whom pulmonary mucormycosis was diagnosed during his first-ever episode of diabetic ketoacidosis. While receiving liposomal amphotericin B, a sinusal aspergillosis due to Aspergillus fumigatus occurred. Evolution was slowly favorable under antifungal tritherapy by liposomal amphotericin B, posaconazole and caspofungin...
March 2018: Medical Mycology Case Reports
https://www.readbyqxmd.com/read/29186239/cutaneous-mucormycosis
#17
Ana Daniela Castrejón-Pérez, Esperanza C Welsh, Ivett Miranda, Jorge Ocampo-Candiani, Oliverio Welsh
Cutaneous mucormycosis is an emerging fungal infection caused by opportunistic fungi of the phylum Glomeromycota. It is frequent in poorly controlled diabetic patients and individuals with immunosuppression. It is usually acquired by direct inoculation through trauma. The clinical presentation is nonspecific, but an indurated plaque that rapidly evolves to necrosis is a common finding. Diagnosis should be confirmed by demonstration of the etiological agent and new molecular diagnostic tools have recently been described...
May 2017: Anais Brasileiros de Dermatologia
https://www.readbyqxmd.com/read/29178247/isavuconazole-shortens-the-qtc-interval
#18
Sibylle C Mellinghoff, Matteo Bassetti, Daniela Dörfel, Stefan Hagel, Nicola Lehners, Andrzej Plis, Enrico Schalk, Antonio Vena, Oliver A Cornely
BACKGROUND: Isavuconazole is a novel antifungal drug, approved for treatment of adults with invasive aspergillosis and mucormycosis. While azoles as a class effect are known to prolong QTc interval, clinical trials have shown that isavuconazole administration may cause shortening in a dose-related manner. Here, we assessed the effects of isavuconazole on the length of QTc interval. OBJECTIVES: To describe changes of the QTc interval induced by isavuconazole treatment...
November 25, 2017: Mycoses
https://www.readbyqxmd.com/read/29172240/disseminated-mucormycosis-masquerading-as-rejection-early-after-orthotopic-heart-transplantation
#19
Lindsay Margoles, David DeNofrio, Ayan Patel, Yoav Golan, Amanda Vest, Knarik Arkun, Helen Boucher, Michael Kiernan, Jenica Upshaw
Mucorales organisms are an uncommon cause of invasive fungal infections after solid organ transplantation but are associated with great morbidity and mortality. We report a fatal case of disseminated Cunninghamella infection early after heart transplantation. The patient developed graft dysfunction and elevated markers of myocyte injury and autopsy revealed fulminant fungal myocarditis. This case highlights the need for a high index of suspicion in immunocompromised patients who are not improving with standard antimicrobial therapy...
November 24, 2017: Transplant Infectious Disease: An Official Journal of the Transplantation Society
https://www.readbyqxmd.com/read/29171398/primary-cutaneous-mucormycosis-as-a-complication-of-erosive-dermatitis-two-cases
#20
Devy Lu, Camille Hua, Amandine Servy, Francoise Foulet, Francoise Botterel, Nicolas De Prost, Olivier Ellrodt, Berline Sigha, Dragos Popescu, Nicolas Ortonne, Pierre Wolkenstein, Saskia Ingen-Housz-Oro, Olivier Chosidow
No abstract text is available yet for this article.
November 24, 2017: European Journal of Dermatology: EJD
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