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Mucormycosis

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https://www.readbyqxmd.com/read/28220379/pulmonary-mucormycosis-clinical-features-and-outcomes
#1
Erica Lin, Teng Moua, Andrew H Limper
PURPOSE: Mucormycosis encompasses a group of opportunistic fungal infections caused by Zygomycetes, order Mucorales. Mucormycosis can manifest as rhino-orbito-cerebral, pulmonary, gastrointestinal, cutaneous, and disseminated infections. Pulmonary mucormycosis is the second most common presentation. This manuscript characterizes the demographics, clinical presentation, diagnostic procedures, radiologic findings, therapeutic interventions, and outcome in pulmonary mucormycosis. METHODS: We retrospectively reviewed clinical data of 35 patients with pulmonary mucormycosis from 2000 to 2015...
February 20, 2017: Infection
https://www.readbyqxmd.com/read/28220322/serious-fungal-infections-in-the-philippines
#2
M C R Batac, D Denning
The Philippines is a low middle-income, tropical country in Southeast Asia. Infectious diseases remain the main causes of morbidity, including tuberculosis. AIDS/HIV prevalence is still low at <1%, but is rapidly increasing. Fungal disease surveillance has not been done, and its burden has never been estimated. This becomes more important as the population of immunocompromised patients increases, drawn from patients with AIDS, TB, malignancies, and autoimmune diseases requiring chronic steroid use. Using the methodology of the LIFE program ( www...
February 21, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28218019/nucleic-acid-amplification-methodologies-for-the-detection-of-pulmonary-mold-infections
#3
Matthew William McCarthy, Ruta Petraitiene, Thomas J Walsh
The detection of pulmonary mold infections has historically required technically demanding methods obtained through invasive procedures. Nucleic acid amplification assays have the potential to circumvent the technical hurdles associated with diagnosis, but are not without potential pitfalls. Areas covered: In this paper, the authors review new assays for the diagnosis of pulmonary mold infections due to aspergillosis, mucormycosis, and hyalohyphomycoses as well as uncommon infections caused by dematiaceous molds...
March 2017: Expert Review of Molecular Diagnostics
https://www.readbyqxmd.com/read/28214142/-a-case-of-rhinofacial-entomophthoromycosis-in-soudano-sahelian-tropical-climate-in-burkina-faso
#4
S Bamba, V Konsegré, A Zida, I Sangaré, M Cissé, R Beogo, B Diallo, J B Andonaba, R T Guiguemdé
We describe a rhinofacial entomophthoramycosis case in a sexagenarian (65 years old) housewife. She was immunocompetent and resident of Burkina Faso. She consulted both the service of dermatology and the service of stomatology of the Teaching Hospital of Bobo-Dioulasso in February 2016 for a diffuse facial tumefaction evolving over six months. This tumefaction was associated with headaches and a left nasal obstruction. Histological examination of the lesion showed an important and polymorphic inflammatory reaction...
February 14, 2017: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/28209649/isolated-pulmonary-mucormycosis
#5
Raj Kumar Mani, Vipul Mishra, Manish Sharma, Raghupathy Ashok Kumar
No abstract text is available yet for this article.
February 16, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28199672/identification-of-a-novel-rhizopus-specific-antigen-by-screening-with-a-signal-sequence-trap-and-evaluation-as-a-possible-diagnostic-marker-of-mucormycosis
#6
Kanako Sato, Ken-Ichi Oinuma, Mamiko Niki, Satoshi Yamagoe, Yoshitsugu Miyazaki, Kazuhisa Asai, Koichi Yamada, Kazuto Hirata, Yukihiro Kaneko, Hiroshi Kakeya
No abstract text is available yet for this article.
February 11, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28191796/the-cost-of-treating-mucormycosis-with-isavuconazole-compared-with-standard-therapy-in-the-uk
#7
Emma Bagshaw, Daniel Kuessner, Jan Posthumus, Cesar Escrig, Michael Blackney, Sebastian Marcel Heimann, Oliver Andreas Cornely
AIM: Mucormycosis is a fungal infection associated with high mortality. Until recently, the only licensed treatments were amphotericin B (AMB) formulations. Isavuconazole (ISAV) is a new mucormycosis treatment. A UK-based economic model explored treatment costs with ISAV versus liposomal AMB followed by posaconazole. MATERIALS & METHODS: As a matched case-control analysis showed similar efficacy for ISAV and AMB, a cost-minimization approach was taken. Direct costs - drug acquisition, monitoring and administration, and hospitalization costs - were estimated from the National Health Service perspective...
February 13, 2017: Future Microbiology
https://www.readbyqxmd.com/read/28161741/serious-fungal-infections-in-pakistan
#8
K Jabeen, J Farooqi, S Mirza, D Denning, A Zafar
The true burden of fungal infection in Pakistan is unknown. High-risk populations for fungal infections [tuberculosis (TB), diabetes, chronic respiratory diseases, asthma, cancer, transplant and human immunodeficiency virus (HIV) infection] are numerous. Here, we estimate the burden of fungal infections to highlight their public health significance. Whole and at-risk population estimates were obtained from the WHO (TB), BREATHE study (COPD), UNAIDS (HIV), GLOBOCAN (cancer) and Heartfile (diabetes). Published data from Pakistan reporting fungal infections rates in general and specific populations were reviewed and used when applicable...
February 4, 2017: European Journal of Clinical Microbiology & Infectious Diseases
https://www.readbyqxmd.com/read/28156016/severe-pneumonia-associated-with-ibrutinib-monotherapy-for-cll-and-lymphoma
#9
Natalia Kreiniz, Jacob Bejar, Aaron Polliack, Tamar Tadmor
In recent years, there have been major advances in the treatment of chronic lymphocytic leukemia (CLL) particularly since the development of novel therapeutic agents, mostly "biological drugs." One of the obvious advantages of these agents is the decreased rate of infectious complications occurring during the course of therapy, compared to the use of standard immuno-chemotherapy regimens. Here, we describe 3 patients with CLL and 1 with mantle cell lymphoma who developed severe life-threatening pneumonias, during monotherapy with ibrutinib...
February 3, 2017: Hematological Oncology
https://www.readbyqxmd.com/read/28118556/investigation-into-individual-health-and-exposure-to-infectious-agents-of-platypuses-ornithorhynchus-anatinus-in-two-river-catchments-in-northwest-tasmania
#10
James W Macgregor, Carly S Holyoake, Sarah A Munks, Joanne H Connolly, Ian D Robertson, Patricia A Fleming, Kristin S Warren
Changes in the health of individuals within wildlife populations can be a cause or effect of population declines in wildlife species. Aspects of individual platypus ( Ornithorhynchus anatinus ) health have been reported. However, holistic studies investigating potential synergistic effects of both pathogens and environmental factors are needed to expand understanding of platypus individual health. We collected baseline data on the health of platypuses in two Tasmanian river catchments (including evidence of the potentially fatal fungal disease mucormycosis) and on individual, demographic, geographic, and temporal patterns associated with health data results...
January 24, 2017: Journal of Wildlife Diseases
https://www.readbyqxmd.com/read/28107502/rnai-based-functional-genomics-identifies-new-virulence-determinants-in-mucormycosis
#11
Trung Anh Trieu, María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Marta Sanchis, Javier Capilla, Patricia Navarro-Rodriguez, Loida Lopez-Fernandez, Santiago Torres-Martínez, Victoriano Garre, Rosa María Ruiz-Vázquez, Francisco E Nicolás
Mucorales are an emerging group of human pathogens that are responsible for the lethal disease mucormycosis. Unfortunately, functional studies on the genetic factors behind the virulence of these organisms are hampered by their limited genetic tractability, since they are reluctant to classical genetic tools like transposable elements or gene mapping. Here, we describe an RNAi-based functional genomic platform that allows the identification of new virulence factors through a forward genetic approach firstly described in Mucorales...
January 2017: PLoS Pathogens
https://www.readbyqxmd.com/read/28101518/is-it-time-to-include-ct-reverse-halo-sign-and-qpcr-targeting-mucorales-in-serum-to-eortc-msg-criteria-for-the-diagnosis-of-pulmonary-mucormycosis-in-leukemia-patients
#12
Denis Caillot, Stéphane Valot, Ingrid Lafon, Louise Basmaciyan, Marie Lorraine Chretien, Marc Sautour, Laurence Million, Caroline Legouge, Alexandre Payssot, Frédéric Dalle
In 23 leukemia patients with proven (n = 17) or possible (n = 6) pulmonary mucormycosis (PM), the presence of reversed halo sign on computed tomography was strongly associated with the positivity of quantitative polymerase chain reaction assays targeting Mucorales in the serum, confirming the value of these two tools for the diagnosis of PM in this setting.
October 2016: Open Forum Infectious Diseases
https://www.readbyqxmd.com/read/28100955/gastric-mucormycosis-presenting-as-gastrocolic-fistula-a-rare-entity
#13
Tarun Mittal, Mohan Venkatesh Pulle, Ashish Dey, Vinod K Malik
No abstract text is available yet for this article.
December 2016: Indian Journal of Surgery
https://www.readbyqxmd.com/read/28100573/mucormycosis-pulmonary-abscess-containment-in-a-patient-with-uncontrolled-diabetes-mellitus
#14
Faraz Jaffer, Norman Beatty, Kareem Ahmad
A 56-year-old Hispanic male with solo risk factor of uncontrolled diabetes mellitus presented with recurrent haemoptysis. Initial concern was for malignancy with postobstructive pneumonia; however, invasive testing and biopsy confirmed infectious mass of fungal aetiology requiring surgical resection followed by a prolonged course of anti-fungal therapy. Discussion centred on approach to, progression of and course of action in the management of pulmonary abscess due to mucormycosis.
January 18, 2017: BMJ Case Reports
https://www.readbyqxmd.com/read/28063611/pulmonary-mucormycosis-at-onset-of-diabetes-in-a-young-patient
#15
Javier Espíldora-Hernández, Carmen Pérez-López, Manuel Abarca-Costalago, Enrique Nuño-Álvarez
No abstract text is available yet for this article.
January 4, 2017: Archivos de Bronconeumología
https://www.readbyqxmd.com/read/28053147/bone-and-joint-infections-caused-by-mucormycetes-a-challenging-osteoarticular-mycosis-of-the-twenty-first-century
#16
Saad J Taj-Aldeen, Maria N Gamaletsou, Blandine Rammaert, Nikolaos V Sipsas, Valerie Zeller, Emmanuel Roilides, Dimitrios P Kontoyiannis, Michael Henry, Vidmantas Petraitis, Brad Moriyama, David W Denning, Olivier Lortholary, Thomas J Walsh
Osteomyelitis and arthritis caused by mucormycetes are rare diseases that rank among the most challenging complications in orthopedic and trauma surgery. The aim of this work is to review the epidemiological, clinical, diagnostic, and therapeutic aspects of the osteoarticular mucormycosis with particular emphasis on high-risk patients. A systematic review of osteoarticular mucormycosis was performed using PUBMED and EMBASE databases from 1978 to 2014. Among 34 patients with median age 41 (0.5-73 years), 24 (71%) were males...
January 3, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/28019140/cutaneous-mucormycosis-as-result-of-insulin-administration-in-an-aml-patient-case-report-and-review-of-the-literature
#17
Anke Delie, Philip Vlummens, David Creytens, Eva Steel
We present a case of cutaneous mucormycosis in a patient with several important risk factors precipitating disease, namely underlying acute myeloid leukaemia and poorly controlled secondary diabetes. Inoculation was most likely caused by repeated minor trauma (insulin injection) at the site of infection. Treatment consisted of surgical debridement and liposomal Amphotericin B (LAmB) during 71 days. Posaconazole had already been initiated prior to infection as primary antifungal prophylaxis but was discontinued during follow-up as susceptibility testing later revealed resistance to posaconazole...
December 26, 2016: Acta Clinica Belgica
https://www.readbyqxmd.com/read/28017141/rhinocerebral-zygomycosis-with-orosinusal-involvement-diagnostic-and-surgical-treatment-guidelines
#18
Giuseppe Giudice, Daniela Anna Cutrignelli, Pasquale Spportelli, Luisa Limongelli, Giuseppe Di Gioia, Luigi Santacroce, Eugenio Maiorano, Gianfranco Favia
Rhinocerebral mucormycosis is a rare, rapidly progressive and potentially lethal disease almost exclusively affecting immunocompromised hosts or patients with metabolic disorders, such as poorly controlled diabetes mellitus. This work is aimed to describe five cases of rhinocerebral mucormycosis to review and possibly define diagnostic and surgical treatment guidelines. In all the patients, surgical debridement, systemic and local antifungal therapy, and oral rehabilitation using filling prostheses were performed...
December 23, 2016: Endocrine, Metabolic & Immune Disorders Drug Targets
https://www.readbyqxmd.com/read/28011902/ecil-6-guidelines-for-the-treatment-of-invasive-candidiasis-aspergillosis-and-mucormycosis-in-leukemia-and-hematopoietic-stem-cell-transplant-patients
#19
Frederic Tissot, Samir Agrawal, Livio Pagano, Georgios Petrikkos, Andreas H Groll, Anna Skiada, Cornelia Lass-Flörl, Thierry Calandra, Claudio Viscoli, Raoul Herbrecht
The European Conference on Infections in Leukemia (ECIL) provides recommendations for diagnostic strategies and prophylactic, pre-emptive or targeted therapy strategies for various types of infection in patients with hematological malignancies or hematopoietic stem cell transplantation recipients. Meetings are held every two years since 2005 and evidence-based recommendations are elaborated after evaluation of the literature and discussion among specialists of nearly all European countries. In this manuscript, the ECIL group presents the 2015-update of the recommendations for the targeted treatment of invasive candidiasis, aspergillosis and mucormycosis...
December 23, 2016: Haematologica
https://www.readbyqxmd.com/read/28001234/abdominal-mucormycosis-in-a-child-a-case-report
#20
Felipe Rezende Caino de Oliveira, Nimara Grace Cardoso Batista Couto, Juliana de Oliveira Bastos, José Colleti, Werther Brunow de Carvalho
A 2-year-old Brazilian female child from the countryside in Bahia State presented with pain in the right flank of the abdomen, accompanied by a daily fever for about 2 weeks before admission. A large mass in the abdomen was resected by the surgical team. The biopsies revealed the mass was an intra-abdominal mucormycosis. However, the diagnosis was late, and despite treatment (amphotericin B) initiation, the patient eventually died.
November 2016: Revista da Sociedade Brasileira de Medicina Tropical
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