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https://www.readbyqxmd.com/read/29769603/components-of-a-new-gene-family-of-ferroxidases-involved-in-virulence-are-functionally-specialized-in-fungal-dimorphism
#1
María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Laura Murcia, Pablo Martínez-García, Carlos Lax, Marta Sanchis, Javier Capilla, Francisco E Nicolás, Victoriano Garre
Mucormycosis is an emerging angio-invasive infection caused by Mucorales that presents unacceptable mortality rates. Iron uptake has been related to mucormycosis, since serum iron availability predisposes the host to suffer this infection. In addition, iron uptake has been described as a limiting factor that determines virulence in other fungal infections, becoming a promising field to study virulence in Mucorales. Here, we identified a gene family of three ferroxidases in Mucor circinelloides, fet3a, fet3b and fet3c, which are overexpressed during infection in a mouse model for mucormycosis, and their expression in vitro is regulated by the availability of iron in the culture media and the dimorphic state...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29754839/-retrospective-study-of-25-cases-of-pulmonary-mucormycosis-in-acute-leukaemia
#2
REVIEW
D Caillot, C Legouge, I Lafon, E Ferrant, P B Pagès, A Plocque, L Estivalet, S Valot, F Dalle, H Abou Hanna, M-L Chretien
INTRODUCTION: In acute leukaemia (AL), the occurrence of pulmonary mucormycosis (PM), the incidence of which is increasing, as a result of chemotherapy induced marrow aplasia, remains a life threatening complication. METHODS: Analysis of clinical, biological and thoracic CT characteristics of patients with PM developing during the treatment of AL between 2000 and 2015. Day 0 (D0) was defined as the day with first CT evidence of PM. RESULTS: Among 1193 patients, 25 cases of PM were recorded during 2099 episodes of bone marrow aplasia...
May 10, 2018: Revue des Maladies Respiratoires
https://www.readbyqxmd.com/read/29744327/management-of-recurrent-rhinomaxillary-mucormycosis-and-nasal-myiasis-in-an-uncontrolled-diabetic-patient-a-systematic-approach
#3
N M Manjunath, Preema Melani Pinto
Mucormycosis is a rare but often fatal fungal infection caused by a group of fungus known as the Mucorales. This fungus can cause varieties of infections in human beings, especially in an immunocompromised condition. According to various studies, the mortality rate ranges from 10% to 100% depending on the location and site of infection accompanied by underlying diseases. Rhinomaxillary involvement is the most common form of mucormycosis predominantly occurring in patients with uncontrolled diabetes. Necrosis of the maxilla in patients with rhinomaxillary form is less evident as the maxilla is richly vascular, but in case of immunocompromised status, it becomes a common clinical finding...
April 2018: International Journal of Applied and Basic Medical Research
https://www.readbyqxmd.com/read/29707667/identification-of-fungal-causative-agents-of-rhinosinusitis-from-mashhad-iran
#4
Mohammad J Najafzadeh, Karim Jalaeian Samani, Jos Houbraken, Majid Alizadeh, Abdolmajid Fata, Ali Naseri, Hossein Zarrinfar, Mehdi Bakhshaee
Background and Purpose: Rhinosinusitis is a common disorder, influencing approximately 20% of the population at some time of their lives. It was recognized and reported with expanding recurrence over the past two decades worldwide. Undoubtedly, correct diagnosis of fungi in patients with fungal rhinosinusitis affects the treatment planning and prognosis of the patients. Identification of the causative agents using the standard mycological procedures remains difficult and time-consuming...
September 2017: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/29691339/outbreak-of-invasive-wound-mucormycosis-in-a-burn-unit-due-to-multiple-strains-of-mucor-circinelloides-f-circinelloides-resolved-by-whole-genome-sequencing
#5
Dea Garcia-Hermoso, Alexis Criscuolo, Soo Chan Lee, Matthieu Legrand, Marc Chaouat, Blandine Denis, Matthieu Lafaurie, Martine Rouveau, Charles Soler, Jean-Vivien Schaal, Maurice Mimoun, Alexandre Mebazaa, Joseph Heitman, Françoise Dromer, Sylvain Brisse, Stéphane Bretagne, Alexandre Alanio
Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015)...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29689046/evolutionary-novelty-in-gravity-sensing-through-horizontal-gene-transfer-and-high-order-protein-assembly
#6
Tu Anh Nguyen, Jamie Greig, Asif Khan, Cara Goh, Gregory Jedd
Horizontal gene transfer (HGT) can promote evolutionary adaptation by transforming a species' relationship to the environment. In most well-understood cases of HGT, acquired and donor functions appear to remain closely related. Thus, the degree to which HGT can lead to evolutionary novelties remains unclear. Mucorales fungi sense gravity through the sedimentation of vacuolar protein crystals. Here, we identify the octahedral crystal matrix protein (OCTIN). Phylogenetic analysis strongly supports acquisition of octin by HGT from bacteria...
April 2018: PLoS Biology
https://www.readbyqxmd.com/read/29674435/phylogenetic-and-phylogenomic-definition-of-rhizopus-species
#7
Andrii P Gryganskyi, Jacob Golan, Somayeh Dolatabadi, Stephen Mondo, Sofia Robb, Alexander Idnurm, Anna Muszewska, Kamil Steczkiewicz, Sawyer Masonjones, Hui-Ling Liao, Michael T Gajdeczka, Felicia Anike, Antonina Vuek, Iryna M Anishchenko, Kerstin Voigt, G Sybren de Hoog, Matthew E Smith, Joseph Heitman, Rytas Vilgalys, Jason E Stajich
Phylogenomic approaches have the potential to improve confidence about the inter-relationships of species in the order Mucorales within the fungal tree of life. Rhizopus species are especially important as plant and animal pathogens and bioindustrial fermenters for food and metabolite production. A dataset of 192 orthologous genes was used to construct a phylogenetic tree of 21 Rhizopus strains, classified into four species isolated from habitats of industrial, medical and environmental importance. The phylogeny indicates that the genus Rhizopus consists of three major clades, with R...
April 19, 2018: G3: Genes—Genomes—Genetics
https://www.readbyqxmd.com/read/29668130/-rhino-orbito-cerebral-mucormycosis-from-dental-origin-case-report
#8
José Humberto Bravo, Andrés Mauricio Agudelo, Armando Cortés, Lorena Matta
Rhino-orbito-cerebral mucormycosis from dental origin is an acute infection caused by opportunistic fungi belonging to the order of Mucorales, which affects mainly diabetic and immunocompromised patients.We report the case of a 63-year old diabetic man who performed a dental extraction on himself by his own means and subsequently developed a rhino-orbito-cerebral mucormycosis with cutaneous and palatal affection. The species isolated in the mycological culture was Rhizopus sp.
March 15, 2018: Biomédica: Revista del Instituto Nacional de Salud
https://www.readbyqxmd.com/read/29558254/acute-invasive-fungal-rhinosinusitis-in-immunocompromised-patients-role-of-an-early-diagnosis
#9
Ignacio Javier Fernandez, Francesco Maria Crocetta, Marco Demattè, Paolo Farneti, Marta Stanzani, Russel E Lewis, Martina Fornaciari, Ernesto Pasquini, Vittorio Sciarretta
Objective The aims of the present study were to evaluate the clinical significance of the delay for surgical treatment and the prognostic value of other clinical, pathologic, and microbiological variables among hematologic patients affected by acute invasive fungal rhinosinusitis (AIFRS). Furthermore, we propose our early diagnosis and treatment protocol, reporting its 10-year results. Study Design Monocentric retrospective analysis. Setting The study was conducted from 2001 to 2017 at the University Hospital of Bologna, Italy...
March 1, 2018: Otolaryngology—Head and Neck Surgery
https://www.readbyqxmd.com/read/29551442/isavuconazole-a-new-broad-spectrum-azole-part-2-pharmacokinetics-and-clinical-activity
#10
REVIEW
M-P Ledoux, J Denis, Y Nivoix, R Herbrecht
Isavuconazole, the active moiety of its prodrug isavuconazonium, is a new extended-spectrum triazole whose activity against yeasts, molds, including Aspergillus and mucorales, and dimorphic fungi has been shown in vitro and in preclinical models. The most relevant pharmacokinetics features are water-solubility of the prodrug, rapid cleavage of the prodrug into active moiety and cleavage product by plasmatic esterases, high oral bioavailability of isavuconazole with an extensive penetration into most tissues and a good safety profile even in case of renal impairment...
March 15, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29550627/microbiologic-diagnostic-workup-of-acute-respiratory-failure-with-pulmonary-infiltrates-after-allogeneic-hematopoietic-stem-cell-transplantation-findings-in-the-era-of-molecular-and-biomarker-based-assays
#11
Philipp Wohlfarth, Amin T Turki, Joerg Steinmann, Melanie Fiedler, Nina K Steckel, Dietrich W Beelen, Tobias Liebregts
Allogeneic hematopoietic stem cell transplantation (HSCT) recipients frequently develop acute respiratory failure (ARF) with pulmonary infiltrates. Molecular- and biomarker-based assays enhance pathogen detection, but data on their yield in this population are scarce. This was a retrospective single-center study of 156 consecutive HSCT recipients admitted to the intensive care unit (ICU) between May 2013 and July 2017. Findings from a microbiologic diagnostic workup using currently available methods on bronchoalveolar lavage (BAL) and blood samples from 66 patients (age, 58 years [range, 45 to 64]; HSCT to ICU, 176 days [range, 85 to 407]) with ARF and pulmonary infiltrates were analyzed...
March 14, 2018: Biology of Blood and Marrow Transplantation
https://www.readbyqxmd.com/read/29545123/mucormycosis-in-iran-a-six-year-retrospective-experience
#12
S Dolatabadi, B Ahmadi, A Rezaei-Matehkolaei, H Zarrinfar, A Skiada, H Mirhendi, R Nashibi, F Niknejad, M Nazeri, A Rafiei, M Gharaghani, M Erami, S Taghipour, F Piri, K Makimura
Mucormycosis is a devastating infection caused by Mucoralean fungi (Mucormycotina, Mucorales). Data concerning the global epidemiology of mucormycosis are scarce and little is known about the characteristics of mucormycosis in Iran. In this study, we aimed to understand the distribution of this infection in Iran retrospectively and to ascertain whether the patterns of infection are associated with specific host factors or not. A total of 208 cases were included in this study occurring during 2008-2014 and were validated according to (EORTC/MSG) criteria...
March 12, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29545122/fulminant-mucormycosis-of-maxillary-sinuses-after-dental-extraction-inpatients-with-uncontrolled-diabetic-two-case-reports
#13
N Gholinejad Ghadi, Z Seifi, T Shokohi, S R Aghili, M Nikkhah, L Vahedi Larijani, M Ghasemi, I Haghani
Mucormycosis is a rare but fulminant opportunistic fungal infection, which occurs most often in diabetic and immunocompromised patients. Dental extractions may create a portal of entry for the fungal infection. The mucormycosis may be the original cause of the pain and can be misdiagnosed as dental pain. In this paper, two cases of mucormycosis are reported after dental extractions and successfully treated with amphotericin B (case #1) and combined with posaconazole (case #2). The two cases we describe exemplify the fulminant mucormycosis of maxillary sinuses after dental extraction inpatients with uncontrolled diabetic support the findings that this predisposing condition created a suitable environment for the Mucorales growth...
March 12, 2018: Journal de Mycologie Médicale
https://www.readbyqxmd.com/read/29491619/mucormycosis-in-immunocompetent-patient-resulting-in-extensive-maxillary-sequestration
#14
Deepak Venkatesh, Satyajit Dandagi, Pramod Redder Chandrappa, K N Hema
Mucormycosis or zygomycosis, also called phycomycosis, is an uncommon, invasive, potentially lethal and an aggressive fungal infection of the order Mucorales that usually affects patients with alteration of their immunological system. From its initial description (Paltauf, 1885), this entity still has a high mortality. Imaging techniques are not usually diagnostic, and cultures are not totally reliable. Definitive diagnosis is exclusively obtained by means of histopathological examination. Early recognition and aggressive treatment are of paramount importance and have reduced the mortality and morbidity...
January 2018: Journal of Oral and Maxillofacial Pathology: JOMFP
https://www.readbyqxmd.com/read/29491339/-histopathological-diagnosis-of-invasive-fungal-infections-in-formalin-fixed-and-paraffin-embedded-tissues-in-conjunction-with-molecular-methods
#15
COMPARATIVE STUDY
Minoru Shinozaki, Naobumi Tochigi, Sota Sadamoto, Somay Yamagata Murayama, Megumi Wakayama, Tetsuo Nemoto
The main objective of this study was to evaluate the relationship between histopathology, polymerase chain reaction (PCR), and in situ hybridization (ISH) for the identification of causative fungi in formalin-fixed and paraffin-embedded (FFPE) tissue specimens. Since pathogenic fungi in tissue specimens can be difficult to identify morphologically, PCR and ISH have been usually employed as auxiliary procedures. However, little comparison has been made on the sensitivity and specificity of PCR and ISH using FFPE specimens...
2018: Medical Mycology Journal
https://www.readbyqxmd.com/read/29483124/-in-situ-validation-of-the-endothelial-cell-receptor-grp78-in-a-case-of-rhinocerebral-mucormycosis
#16
LETTER
Evgenii Shumilov, Ulrike Bacher, Christina Perske, Alexander Mohr, Helmut Eiffert, Justin Hasenkamp, Lorenz Trümper, Gerald G Wulf, Philipp Ströbel, Ashraf S Ibrahim, Vivek Venkataramani
No abstract text is available yet for this article.
May 2018: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/29437814/isolated-splenic-mucormycosis-in-a-case-of-aplastic-anaemia
#17
Shefali K Sharma, Prasanth Balasubramanian, Bishan Radotra, Manphool Singhal
Mucormycosis, a rare opportunistic infection seen in immunocompromised hosts, is caused by fungi of Mucorales family. It may be confined to the organs, such as rhinocerebral and pulmonary mucormycosis, or may cause disseminated infection. A 14-year-old boy presented to our clinic with fever and left upper quadrant abdominal pain, and on evaluation was found to have pancytopaenia, and imaging revealed ill-defined splenic collection with thrombus in the splenic vein. He was started on empirical intravenous antibiotics, followed by antifungals empirically as he did not show any improvement clinically...
February 8, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29436903/understanding-mucor-circinelloides-pathogenesis-by-comparative-genomics-and-phenotypical-studies
#18
Loida López-Fernández, Marta Sanchis, Patricia Navarro-Rodríguez, Francisco E Nicolás, Fátima Silva-Franco, Josep Guarro, Victoriano Garre, María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Javier Capilla
The increasing number of infections by species of Mucorales and their high mortality constitute an important concern for public health. This study aims to decipher the genetic basis of Mucor circinelloides pathogenicity, which displays virulence in a strain dependent manner. Assuming that genetic differences between strains may be linked to different pathotypes, we have conducted a study to explore genes responsible for virulence in M. circinelloides by whole genome sequencing of the avirulent strain NRRL3631 and comparison with the virulent strain CBS277...
December 31, 2018: Virulence
https://www.readbyqxmd.com/read/29436422/species-identification-and-delineation-of-pathogenic-mucorales-by-matrix-assisted-laser-desorption-ionization-time-of-flight-mass-spectrometry
#19
Jin Shao, Zhe Wan, Ruoyu Li, Jin Yu
This study aimed to validate the effectiveness of matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS)-based identification of filamentous fungi of the order Mucorales. A total of 111 isolates covering six genera preserved at the Research Center for Medical Mycology of Peking University were selected for MALDI-TOF MS analysis. We emphasized the study of 23 strains of Mucor irregularis predominantly isolated from patients in China. We first used the Bruker Filamentous Fungi library (v1...
April 2018: Journal of Clinical Microbiology
https://www.readbyqxmd.com/read/29432820/real-time-polymerase-chain-reaction-detection-of-lichtheimia-species-in-bandages-associated-with-cutaneous-mucormycosis-in-burn-patients
#20
E Fréalle, S Rocchi, M Bacus, H Bachelet, L Pasquesoone, B Tavernier, D Mathieu, L Millon, M Jeanne
BACKGROUND: Cutaneous mucormycoses, mainly due to Lichtheimia (Absidia), have occurred on several occasions in the Burn Unit of the University Hospital of Lille, France. AIM: To investigate the potential vector role of non-sterile bandages used to hold in place sterile gauze used for wound dressing. METHODS: Mycological analysis by conventional culture, Mucorales real-time polymerase chain reaction (qPCR), and Lichtheimia species-specific qPCR were performed on eight crepe and six elasticized bandages that were sampled on two independent occasions in March 2014 and July 2016...
May 2018: Journal of Hospital Infection
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