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https://www.readbyqxmd.com/read/29326525/mucormycosis-in-a-diabetic-patient-a-case-report-with-an-insight-into-its-pathophysiology
#1
Syeda Neelam Afroze, Rajani Korlepara, Guttikonda Venkateswara Rao, Jayakiran Madala
Mucormycosis is one of the most rapidly progressing and fulminant forms of fungal infection which usually begins in the nose and paranasal sinuses following inhalation of fungal spores. It is caused by organisms of the subphylum Mucormycotina, including genera as Absidia, Mucor, Rhizomucor, and Rhizopus. The incidence of mucormycosis is approximately 1.7 cases per 1,000,000 inhabitants per year. Mucormycosis affecting the maxilla is rare because of rich blood vessel supply of maxillofacial areas although more virulent fungi such as Mucor can overcome this difficulty...
October 2017: Contemporary Clinical Dentistry
https://www.readbyqxmd.com/read/29297721/mucor-circinelloides-induces-platelet-aggregation-through-integrin-%C3%AE-iib%C3%AE-3-and-fc%C3%AE-riia
#2
Harlene Ghuman, Alicia Shepherd-Roberts, Stephanie Watson, Malou Zuidscherwoude, Steve P Watson, Kerstin Voelz
Thrombosis is a hallmark of the fatal fungal infection mucormycosis. Yet, the platelet activation pathway in response to mucormycetes is unknown. In this study we determined the platelet aggregation potential of Mucor circinelloides (M. circinelloides) NRRL3631, characterized the signaling pathway facilitating aggregation in response to fungal spores, and identified the influence of the spore developmental stage upon platelet aggregation potential. Using impedance and light-transmission aggregometry, we showed that M...
January 3, 2018: Platelets
https://www.readbyqxmd.com/read/29261310/oxygenated-n-acyl-alanine-methyl-esters-names-from-the-marine-bacterium-roseovarius-tolerans-el-164
#3
Hilke Bruns, Jennifer Herrmann, Rolf Müller, Hui Wang, Irene Wagner Döbler, Stefan Schulz
The marine bacterium Roseovarius tolerans EL-164 (Rhodobacteraceae) can produce unique N-acylalanine methyl esters (NAMEs) besides strucutrally related N-acylhomoserine lactones (AHLs), bacterial signaling compounds widespread in the Rhodobacteraceae. The structures of two unprecedented NAMEs carrying a rare terminally oxidized acyl chain are reported here. The compounds (Z)-N-16-hydroxyhexadec-9-enoyl-l-alanine methyl ester (Z9-16-OH-C16:1-NAME, 3) and (Z)-N-15-carboxypentadec-9-enoyl-l-alanine methyl ester (16COOH-C16:1-NAME, 4) were isolated, and the structures were determined by NMR and MS experiments...
December 20, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29260551/identification-and-characterization-of-diacylglycerol-acyltransferase-from-oleaginous-fungus-mucor-circinelloides
#4
Luning Zhang, Huaiyuan Zhang, Yuanda Song
Acyl-CoA:diacylglycerol acyltransferase (DGAT) is an pivotal regulator of triacylglycerol (TAG) synthesis. The oleaginous fungus Mucor circinelloides has four putative DGATs, McDGAT1A, McDGAT1B, McDGAT2A and McDGAT2B, classified into the DGAT1 and DGAT2 subfamilies, respectively. To identify and characterize DGATs in M. circinelloides, these four genes were expressed in Saccharomyces cerevisiae H1246 (TAG-deficient quadruple mutant), individually. TAG biosynthesis was restored only by the expression of McDGAT2B, and TAG content was significantly higher in the mutants with McDGAT2B expression than in a S...
December 20, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/29259862/disseminated-mucormycosis-a-sinister-cause-of-neutropenic-fever-syndrome
#5
Ghazal Tansir, Neha Rastogi, Prashant Ramteke, Prabhat Kumar, Manish Soneja, Ashutosh Biswas, Sanchit Kumar, Pankaj Jorwal, Upendra Baitha
A 15 year old girl presented with complaints of prolonged fever and recurrent episodes of hemoptysis. Initial investigation showed pancytopenia and radiological imaging was suggestive of necrotizing pneumonia. Subsequently, mucor was isolated from bronchoalveolar lavage fluid, but even on appropriate medications her condition kept deteriorating. She had multiple bouts of hemoptysis and a repeat imaging of chest showed dissemination of mucormycosis to pulmonary vein and heart. Bone marrow biopsy identified acute lymphoblastic leukemia (ALL) as the cause of pancytopenia...
November 2017: Intractable & Rare Diseases Research
https://www.readbyqxmd.com/read/29196656/development-of-a-plasmid-free-crispr-cas9-system-for-the-genetic-modification-of-mucor-circinelloides
#6
Gábor Nagy, Csilla Szebenyi, Árpád Csernetics, Amanda Grace Vaz, Eszter Judit Tóth, Csaba Vágvölgyi, Tamás Papp
Mucor circinelloides and other members of Mucorales are filamentous fungi, widely used as model organisms in basic and applied studies. Although genetic manipulation methods have been described for some Mucoral fungi, construction of stable integrative transformants by homologous recombination has remained a great challenge in these organisms. In the present study, a plasmid free CRISPR-Cas9 system was firstly developed for the genetic modification of a Mucoral fungus. The described method offers a rapid but robust tool to obtain mitotically stable mutants of M...
December 1, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29189511/invasive-fungal-disease-in-pediatric-acute-leukemia-in-the-nontransplant-setting-8-years-experience-from-a-tertiary-care-center-in-north-india
#7
Anirban Das, Sapna Oberoi, Amita Trehan, Arunaloke Chakrabarti, Deepak Bansal, Akshay K Saxena, Kushaljit S Sodhi, Nandita Kakkar, Radhika Srinivasan
BACKGROUND/AIM: The aim of this article is to study the spectrum, changing prevalence, and predictors for mortality of invasive fungal disease (IFD) in pediatric leukemia in a resource-limited setting. OBSERVATIONS: Prevalence was 7% (proven, 69%; probable, 16.4%; possible, 14.6%) and did not differ between acute lymphoblastic leukemia and acute myeloid leukemia. Lungs were frequently involved (46%). Aspergillus was the commonest fungus (47%). Visceral abscesses were frequent with candidiasis as compared with invasive molds (P=0...
November 17, 2017: Journal of Pediatric Hematology/oncology
https://www.readbyqxmd.com/read/29186341/invasive-fungal-sinusitis-due-to-mucor-species-in-a-patient-on-ibrutinib
#8
David Phillip Serota, Aneesh K Mehta, Varun K Phadke
No abstract text is available yet for this article.
November 24, 2017: Clinical Infectious Diseases: An Official Publication of the Infectious Diseases Society of America
https://www.readbyqxmd.com/read/29182775/transcriptional-profile-of-the-human-skin-pathogenic-fungus-mucor-irregularis-in-response-to-low-oxygen
#9
Wenqi Xu, Jingwen Peng, Dongmei Li, Clement K M Tsui, Zhimin Long, Qiong Wang, Huan Mei, Weida Liu
No abstract text is available yet for this article.
November 22, 2017: Medical Mycology: Official Publication of the International Society for Human and Animal Mycology
https://www.readbyqxmd.com/read/29177719/structural-features-influential-to-enzymatic-hydrolysis-of-cellulose-solvent-based-pretreated-pinewood-and-elmwood-for-ethanol-production
#10
Behzad Satari, Keikhosro Karimi, Maryam Molaverdi
Dissolution of lignocelluloses in N-methylmorpholine-N-oxide (NMMO or NMO) at moderate conditions, e.g., 120 °C for 3 h under atmospheric pressure, and regeneration with water, is among the most effective nonderivatization pretreatment for the improvement of enzymatic hydrolysis and ethanol production. The effects of the pretreatment on two different types of wood, hardwood elm and softwood pine, were compared via physicochemical structural analyses, i.e., FTIR, XRD, SEM, TGA, and enzyme adsorption techniques, to relate their properties to the extent of enzymatic conversion...
November 24, 2017: Bioprocess and Biosystems Engineering
https://www.readbyqxmd.com/read/29175660/chemo-enzymatic-synthesis-of-the-glucagon-containing-n-linked-oligosaccharide-and-its-characterization
#11
Takayuki Higashiyama, Midori Umekawa, Masaya Nagao, Toshihiko Katoh, Hisashi Ashida, Kenji Yamamoto
The chemo-enzymatic synthesis of an artificially N-glycosylated derivative of glucagon, a peptide hormone that regulates the blood sugar level, is described. We synthesized the glycosylated glucagon by chemical synthesis of an N-acetylglucosaminyl peptide and enzymatic transfer of an oligosaccharide using the transglycosylation activity of the glycosynthase-like mutant of Mucor hiemalis endo-β-N-acetylglucosaminidase (Endo-M) and sialo-oligosaccharide oxazoline as a donor substrate. The sialo-oligosaccharide-attached glucagon synthesized showed high resistance against protease degradation and stimulated the release of glucose from mouse hepatocytes when added to cells...
November 13, 2017: Carbohydrate Research
https://www.readbyqxmd.com/read/29170658/fungal-community-structure-and-as-resistant-fungi-in-a-decommissioned-gold-mine-site
#12
Silvia Crognale, Alessandro D'Annibale, Lorena Pesciaroli, Silvia R Stazi, Maurizio Petruccioli
Although large quantities of heavy metal laden wastes are released in an uncontrolled manner by gold mining activities with ensuing contamination of the surrounding areas, there is scant information on the mycobiota of gold-mine sites. Thus, the present study was aimed to describe the fungal community structure in three differently As- and Hg-polluted soils collected from the Pestarena decommissioned site by using Illumina® metabarcoding. Fungal richness was found to increase as the contamination level increased while biodiversity was not related to the concentrations of inorganic toxicants...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29163403/modeling-the-effect-of-modified-atmospheres-on-conidial-germination-of-fungi-from-dairy-foods
#13
Nicolas Nguyen Van Long, Valérie Vasseur, Olivier Couvert, Louis Coroller, Marion Burlot, Karim Rigalma, Jérôme Mounier
Modified atmosphere packaging (MAP) is commonly applied to extend food shelf-life. Despite growth of a wide variety of fungal contaminants has been previously studied in relation to modified-atmospheres, few studies aimed at quantifying the effects of dioxygen (O2) and carbon dioxide (CO2) partial pressures on conidial germination in solid agar medium. In the present study, an original culture method was developed, allowing microscopic monitoring of conidial germination under modified-atmospheres in static conditions...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29162893/intrinsic-short-tailed-azole-resistance-in-mucormycetes-is-due-to-an-evolutionary-conserved-aminoacid-substitution-of-the-lanosterol-14%C3%AE-demethylase
#14
Rita Caramalho, Joel D A Tyndall, Brian C Monk, Thomas Larentis, Cornelia Lass-Flörl, Michaela Lackner
Mucormycoses are emerging and potentially lethal infections. An increase of breakthrough infections has been found in cohorts receiving short-tailed azoles prophylaxis (e.g. voriconazole (VCZ)). Although VCZ is ineffective in vitro and in vivo, long-tailed triazoles such as posaconazole remain active against mucormycetes. Our goal was to validate the molecular mechanism of resistance to short-tailed triazoles in Mucorales. The paralogous cytochrome P450 genes (CYP51 F1 and CYP51 F5) of Rhizopus arrhizus, Rhizopus microsporus, and Mucor circinelloides were amplified and sequenced...
November 21, 2017: Scientific Reports
https://www.readbyqxmd.com/read/29154198/evaluation-of-antioxidant-dna-targeting-antimicrobial-and-cytotoxic-studies-of-imine-capped-copper-and-nickel-nanoparticles
#15
P Adwin Jose, J Dhaveethu Raja, M Sankarganesh, J Rajesh
In this work, we have synthesized pyrimidine derivatives of Schiff base ligand 2-(4,6-dimethoxypyrimidin-2-ylimino)methyl)-6-methoxyphenol (DPMM) stabilized copper nanoparticles (DPMM-CuNPs) and nickel nanoparticles (DPMM-NiNPs) by modified Brust-Schiffrin technique as two step phase transfer assisted method and confirmed by UV-Visible, SEM and TEM analysis. The free radical scavenging activity of DPMM, DPMM-CuNPs &DPMM-NiNPs with 2, 2'-diphenylpicryl hydrazyl (DPPH), hydrogen peroxide (H2O2) super oxide dismutase (SOD) and nitric oxide (NO) shows that the antioxidant activity of DPMM-CuNPs is higher than DPMM &DPMM-NiNPs...
November 6, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/29125207/specificity-of-donor-structures-for-endo-%C3%A3-n-acetylglucosaminidase-catalyzed-transglycosylation-reactions
#16
Nozomi Ishii, Ken Ogiwara, Kanae Sano, Jyunichi Kumada, Kenji Yamamoto, Yuji Matsuzaki, Ichiro Matsuo
To demonstrate the structural specificity of the glycosyl donor for the transglycosylation reaction using endo-b-N-acetylglucosaminidase from Mucor hiemalis (endo-M), a series of tetrasaccharide oxazoline derivatives was synthesized. These derivatives correspond to the core structure of an asparagine-linked glycoprotein glycan with a b-mannose units of non-natural-type monosaccharides, including b-glucose, b-galactose, and b-talose in place of the b-mannose moiety. Using these tetrasaccharide donors with p-nitrophenyl N-acetylglucosaminide (GlcNAc-pNp), the transglycosylation activity of wild-type (WT) endo-M and two mutants, N175Q and N175A, was examined...
November 10, 2017: Chembiochem: a European Journal of Chemical Biology
https://www.readbyqxmd.com/read/29124969/the-gut-mycobiome-composition-is-linked-to-carotid-atherosclerosis
#17
M R Chacón, J Lozano-Bartolomé, M Portero-Otín, M M Rodríguez, G Xifra, J Puig, G Blasco, W Ricart, F J Chaves, J M Fernández-Real
The mycobiotic component of the microbiota comprises an integral, yet under-researched, part of the gastrointestinal tract. Here, we present a preliminary study of the possible contribution of gut mycobiota to sub-clinical atherosclerosis in a well-characterised group of obese and non-obese subjects in association with the Framingham Risk Score (FRS) and carotid intima-media thickness (cIMT). From all taxa identified, the relative abundance of the phylum Zygomycota, comprising the family Mucoraceae and genus Mucor, was negatively associated with cIMT and this association remained significant after controlling for false discovery rate...
November 10, 2017: Beneficial Microbes
https://www.readbyqxmd.com/read/29111996/microbial-keratitis-after-accelerated-corneal-collagen-cross-linking-in-keratoconus
#18
Prafulla K Maharana, Pranita Sahay, M Sujeeth, Deepali Singhal, Anubha Rathi, Jeewan S Titiyal, Namrata Sharma
PURPOSE: To assess the pattern of microbial keratitis after accelerated corneal collagen cross-linkage (aCXL) in patients with keratoconus. METHOD: The medical records of cases of keratoconus that underwent aCXL from June 2014 to May 2017 were reviewed. Cases that developed microbial keratitis after aCXL were included in the study. The clinical, microbiological profile and the treatment outcomes were evaluated. RESULTS: Of 532 eyes that underwent aCXL, 7 cases developed microbial keratitis during the study period...
November 2, 2017: Cornea
https://www.readbyqxmd.com/read/29108416/chlorflavonin-targets-acetohydroxyacid-synthase-catalytic-subunit-ilvb1-for-synergistic-killing-of-mycobacterium-tuberculosis
#19
Nidja Rehberg, Herve Sergi Akone, Thomas R Ioerger, German Erlenkamp, Georgios Daletos, Holger Gohlke, Peter Proksch, Rainer Kalscheuer
The flavonoid natural compound chlorflavonin was isolated from the endophytic fungus Mucor irregularis, which was obtained from the Cameroonian medicinal plant Moringa stenopetala. Chlorflavonin exhibited strong growth inhibitory activity in vitro against Mycobacterium tuberculosis (MIC90 1.56 μM) while exhibiting no cytotoxicity towards the human cell lines MRC-5 and THP-1 up to concentrations of 100 µM. Mapping of resistance-mediating mutations employing whole-genome sequencing, chemical supplementation assays, molecular docking studies as well as enzymatic characterization revealed that chlorflavonin specifically inhibits the acetohydroxyacid synthase catalytic subunit IlvB1, causing combined auxotrophies to branched chain amino acids and to pantothenic acid...
November 6, 2017: ACS Infectious Diseases
https://www.readbyqxmd.com/read/29100947/evaluation-of-pcr-reverse-line-blot-hybridization-assay-for-simultaneous-identification-of-medically-important-saprophytic-fungi
#20
S Agha Kuchak Afshari, H Rahimi, S J Hashemi, R Daie Ghazvini, H Badali, S Aghaei Gharehbolagh, S Rezaie
BACKGROUND: In immunocompromised patients suffering from invasive fungal infections, rapid identification of fungal species is important since the appropriate treatment is usually related to the responsible species. We describe here, an assay based on combination of PCR and reverse line blot hybridization (PCR/RLB) for differentiation causative agent of fungal infections. MATERIALS AND METHODS: We performed PCR/RLB assay on 10 reference strains, which include Aspergillus species (A...
October 31, 2017: Journal de Mycologie Médicale
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