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https://www.readbyqxmd.com/read/29772665/investigating-the-role-of-gold-nanoparticle-shape-and-size-in-their-toxicities-to-fungi
#1
Kangze Liu, Zhonglei He, Hugh J Byrne, James F Curtin, Furong Tian
Gold nanoparticles (GNPs) are increasingly being used in a wide range of applications, and such they are being released in greater quantities into the environment. Consequently, the environmental effects of GNPs, especially toxicities to living organisms, have drawn great attention. However, their toxicological characteristics still remain unclear. Fungi, as the decomposers of the ecosystem, interact directly with the environment and critically control the overall health of the biosphere. Thus, their sensitivity to GNP toxicity is particularly important...
May 16, 2018: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/29769603/components-of-a-new-gene-family-of-ferroxidases-involved-in-virulence-are-functionally-specialized-in-fungal-dimorphism
#2
María Isabel Navarro-Mendoza, Carlos Pérez-Arques, Laura Murcia, Pablo Martínez-García, Carlos Lax, Marta Sanchis, Javier Capilla, Francisco E Nicolás, Victoriano Garre
Mucormycosis is an emerging angio-invasive infection caused by Mucorales that presents unacceptable mortality rates. Iron uptake has been related to mucormycosis, since serum iron availability predisposes the host to suffer this infection. In addition, iron uptake has been described as a limiting factor that determines virulence in other fungal infections, becoming a promising field to study virulence in Mucorales. Here, we identified a gene family of three ferroxidases in Mucor circinelloides, fet3a, fet3b and fet3c, which are overexpressed during infection in a mouse model for mucormycosis, and their expression in vitro is regulated by the availability of iron in the culture media and the dimorphic state...
May 16, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29756722/-use-of-posaconazole-in-children-experience-in-a-tertiary-pediatric-hospital
#3
María T Rosanova, Carla Voto, María S Mussini, Claudia Sarkis, Sandra Gómez, Norma Sberna, Susana Carnovale, Beatriz Caracciolo, Roberto Lede
There is limited information on the use of posaconazole in children. This retrospective and descriptive study was conducted to evaluate the clinical, microbiological characteristics and evolution of patients treated with posaconazole between August 2010 and March 2017. We included 16 children. Median age: 161 months (interquartile range -IQR- 69-173 m). All had underlying disease and a proven invasive fungal infection. The most frequent isolated were Mucor spp. and Aspergillus spp. The mean posaconazole dose was 600 mg/day (400-800 mg/day) and the median duration of treatment was 223 days (IQR 48-632)...
June 1, 2018: Archivos Argentinos de Pediatría
https://www.readbyqxmd.com/read/29743785/effect-of-organic-dust-exposure-on-pulmonary-functions-in-workers-of-vegetable-market-with-special-reference-to-its-microbial-content
#4
Arun Goel, Balram Ji Omar, Rajesh Kathrotia, Prashant M Patil, Sunita Mittal
Context: Wholesale vegetable market is a rich source of generation of organic dust as loads of fruits and vegetables are loaded and unloaded here daily. Thus, regular workers are exposed to this organic dust for a considerable period of time depending on their work schedule. This study was planned to determine the microbial status of organic dust and to explore its association with pulmonary functions in the workers of wholesale vegetable market in Rishikesh. Materials and Methods: It was a cross-sectional exploratory/observational study...
January 2018: Indian Journal of Occupational and Environmental Medicine
https://www.readbyqxmd.com/read/29739683/fungal-allergy-pattern-of-sensitization-over-the-past-11-years
#5
R Fernández-Soto, E M Navarrete-Rodríguez, B E Del-Rio-Navarro, J J Luis Sienra-Monge, N A Meneses-Sánchez, O J Saucedo-Ramírez
INTRODUCTION AND OBJECTIVES: Although the prevalence of sensitization to fungi is not precisely known, it can reach 50% in inner cities and has been identified as a risk factor in the development of asthma. Whereas the prevalence of allergic diseases is increasing, it is unclear whether the same occurs with sensitization to fungi. PATIENTS AND METHODS: A retrospective study was performed at the "Hospital Infantil de México Federico Gómez". From skin tests taken between 2004 and 2015, information was gathered about Alternaria alternata, Aspergillus fumigatus, Candida albicans, Cladosporium herbarum, Mucor mucedo and Penicillium notatum...
May 5, 2018: Allergologia et Immunopathologia
https://www.readbyqxmd.com/read/29720523/conservation-of-mannan-synthesis-in-fungi-of-the-zygomycota-and-ascomycota-reveals-a-broad-diagnostic-target
#6
Amanda R Burnham-Marusich, Breeana Hubbard, Alexander J Kvam, Marcellene Gates-Hollingsworth, Heather R Green, Eric Soukup, Andrew H Limper, Thomas R Kozel
Ascomycetes and zygomycetes account for the majority of (i) fungi responsible for cutaneous, subcutaneous, and invasive human fungal infections, (ii) plant fungal pathogens, (iii) fungi that threaten global biodiversity, (iv) fungal agents of agricultural spoilage, and (v) fungi in water-damaged buildings. Rapid recognition of fungal infection (or contamination) enables early treatment (or remediation). A bioinformatics search found homologues of Saccharomyces cerevisiae Mnn9p present in members of the Zygomycota and Ascomycota phyla and absent in members of the Chytridiomycota and Basidiomycota...
June 27, 2018: MSphere
https://www.readbyqxmd.com/read/29709685/biocontrol-and-plant-stimulating-potential-of-novel-strain-bacillus-sp-ppm3-isolated-from-marine-sediment
#7
Neda Radovanović, Milica Milutinović, Katarina Mihajlovski, Jelena Jović, Branislav Nastasijević, Mirjana Rajilić-Stojanović, Suzana Dimitrijević-Branković
In the current study, the biocontrol potential of a novel strain Bacillus sp. PPM3 isolated from marine sediment from the Red Sea in Hurghada, Egypt is recognized. This novel strain was selected out of 32 isolates based on its ability to suppress the growth of four plant pathogenic fungi: Aspergillus flavus, Fusarium graminearum, Mucor sp. and Alternaria sp. The new marine strain was identified and characterized by phenotypic and molecular approaches. The culture filtrate of Bacillus sp. PPM3 suppressed the growth and spore germination of all tested fungi in vitro with the highest value of inhibition reported for Mucor sp...
April 27, 2018: Microbial Pathogenesis
https://www.readbyqxmd.com/read/29707367/urokinase-application-for-hemothorax-in-pulmonary-mucormycosis
#8
Lucas Hodel, Ilhan Inci, Urs Schanz, Bart Vrugt, Walter Weder, Sven Hillinger
We present an exemplary case of an immunocompromised patient with pulmonary mucormycosis successfully treated by a combination of surgical removal of the mucor and urokinase to control the recurring hemothorax. The use of urokinase in hemothoraces is a way to reduce repetitive surgeries in weak patients.
March 2018: Journal of Thoracic Disease
https://www.readbyqxmd.com/read/29691339/outbreak-of-invasive-wound-mucormycosis-in-a-burn-unit-due-to-multiple-strains-of-mucor-circinelloides-f-circinelloides-resolved-by-whole-genome-sequencing
#9
Dea Garcia-Hermoso, Alexis Criscuolo, Soo Chan Lee, Matthieu Legrand, Marc Chaouat, Blandine Denis, Matthieu Lafaurie, Martine Rouveau, Charles Soler, Jean-Vivien Schaal, Maurice Mimoun, Alexandre Mebazaa, Joseph Heitman, Françoise Dromer, Sylvain Brisse, Stéphane Bretagne, Alexandre Alanio
Mucorales are ubiquitous environmental molds responsible for mucormycosis in diabetic, immunocompromised, and severely burned patients. Small outbreaks of invasive wound mucormycosis (IWM) have already been reported in burn units without extensive microbiological investigations. We faced an outbreak of IWM in our center and investigated the clinical isolates with whole-genome sequencing (WGS) analysis. We analyzed M. circinelloides isolates from patients in our burn unit (BU1, Hôpital Saint-Louis, Paris, France) together with nonoutbreak isolates from Burn Unit 2 (BU2, Paris area) and from France over a 2-year period (2013 to 2015)...
April 24, 2018: MBio
https://www.readbyqxmd.com/read/29671212/fungal-suppurative-otitis-media-histopathology-among-patients-in-north-india
#10
Rajpal Singh Punia, Surinder K Singhal, Reetu Kundu, Arjun Das, Jagdish Chander
Chronic suppurative otitis media (CSOM) has a substantial worldwide prevalence and is a major cause of hearing impairment. In cases of CSOM unresponsive to local antibiotics, superimposed fungal infection should be suspected. The aim of the present study was to study the spectrum of cases with fungal otitis media. The study was conducted over a period of 12 years (2006-2017). Fifteen cases of CSOM clinically not suspected to be of fungal etiology that underwent surgery with identification of fungal organisms on histopathology were included in the study...
April 18, 2018: Head and Neck Pathology
https://www.readbyqxmd.com/read/29670591/fungal-diversity-and-community-composition-of-culturable-fungi-in-stanhopea-trigrina-cast-gibberellin-producers
#11
Sonia Salazar-Cerezo, Nancy Martinez-Montiel, Maria Del Carmen Cruz-Lopez, Rebeca D Martinez-Contreras
Stanhopea tigrina is a Mexican endemic orchid reported as a threatened species. The naturally occurring microorganisms present in S. tigrina are unknown. In this work, we analyzed the diversity of endophytic and epiphytic culturable fungi in S. tigrina according to morphological and molecular identification. Using this combined approach, in this study we retrieved a total of 634 fungal isolates that presented filamentous growth, which were grouped in 134 morphotypes that were associated to 63 genera, showing that S...
2018: Frontiers in Microbiology
https://www.readbyqxmd.com/read/29668311/chemical-composition-and-antimicrobial-activities-of-essential-oil-from-wedelia-urticifolia-growing-wild-in-hunan-province-china
#12
Junpeng Hu, Mengmeng Jia, Liang Zhu
The essential oil obtained from Wedelia urticifolia growing in Hunan Province, China, was analyzed for the first time by capillary GC and GC-MS. A total of 67 constituents, representing 98.68% in essential oil were identified. The major constituents of the oil were: α-pinene (8.85%), limonene (6.38%), carvacrol (6.15%), caryophyllene (6.08%), spathulenol (5.49%), sabinene (5.36%), camphor (4.34%). Antimicrobial potential of oil against bacterial strains (Pseudomonas aeruginosa, Escherichia coli and Bacillus subtilis, and Staphylococcus aureus), yeast strains (Hansenula anomala and Saccharomy cescerevisiae) and molds (Aspergillus niger, Chaetomium globosum, Mucor racemosus, and Monascus anka) was determined by disc diffusion method and broth micro dilution method, respectively...
April 18, 2018: Natural Product Research
https://www.readbyqxmd.com/read/29660657/hydrothermal-processing-as-pretreatment-for-efficient-production-of-ethanol-and-biogas-from-municipal-solid-waste
#13
Peyman Mahmoodi, Keikhosro Karimi, Mohammad J Taherzadeh
Organic fraction of municipal solid waste (OFMSW) is dominated by carbohydrates, including starch-based and lignocellulosic materials. The OFMSW was hydrothermally pretreated at 100-160 °C for 0-60 min, and then assessed for enzymatic ethanol production, followed by biogas production from the stillage. The highest glucose yield of 520 g/Kg of dry OFMSW, corresponding to 131% increase compared to that of the untreated OFMSW, was obtained after the pretreatment and enzymatic hydrolysis. Through ethanolic fermentation by an inhibitory tolerant fungus, Mucor indicus, 191...
April 6, 2018: Bioresource Technology
https://www.readbyqxmd.com/read/29651400/management-of-a-case-of-mucor-colonization-in-breast-tissue-expander-seroma-pocket
#14
Danielle N Atwood, Pallavi A Kumbla, Brian Yuen, James C Yuen
Mucormycosis has a mortality rate reaching 90%, and is imperative that therapy be initiated rapidly once a diagnosis is made. Successful treatment consists of management of underlying risk factors, surgical debridement, and antifungal therapies. The dilemma whether or not to pursue extensive debridement presents when the wound is cultured positive but the patient is not systemically ill. We present the first reported case of successful medical treatment of a seroma pocket colonized with mucor in a patient undergoing bilateral reconstruction with tissue expander and acellular dermal matrix...
January 2018: World Journal of Plastic Surgery
https://www.readbyqxmd.com/read/29650055/a-combined-effort-to-avoid-strongyle-infection-in-horses-in-an-oceanic-climate-region-rotational-grazing-and-parasiticidal-fungi
#15
José Ángel Hernández, Rita Sánchez-Andrade, Cristiana Filipa Cazapal-Monteiro, Fabián Leonardo Arroyo, Jaime Manuel Sanchís, Adolfo Paz-Silva, María Sol Arias
BACKGROUND: An approach to preventing strongyle infection in horses was tested, comprising rotational pasturing and the administration of spores of two parasiticidal fungi, Mucor circinelloides and Duddingtonia flagrans. METHODS: Twenty-two adult Spanish Sport Horses were dewormed with ivermectin (1 mg pour-on/kg body weight) and then randomly divided into three groups. G-1 was maintained with continuous grazing, and G-2 and G-3 were kept on a four-paddock rotation system...
April 12, 2018: Parasites & Vectors
https://www.readbyqxmd.com/read/29644428/assessment-of-the-scalability-of-a-microtiter-plate-system-for-screening-of-oleaginous-microorganisms
#16
Gergely Kosa, Kiira S Vuoristo, Svein Jarle Horn, Boris Zimmermann, Nils Kristian Afseth, Achim Kohler, Volha Shapaval
Recent developments in molecular biology and metabolic engineering have resulted in a large increase in the number of strains that need to be tested, positioning high-throughput screening of microorganisms as an important step in bioprocess development. Scalability is crucial for performing reliable screening of microorganisms. Most of the scalability studies from microplate screening systems to controlled stirred-tank bioreactors have been performed so far with unicellular microorganisms. We have compared cultivation of industrially relevant oleaginous filamentous fungi and microalga in a Duetz-microtiter plate system to benchtop and pre-pilot bioreactors...
April 11, 2018: Applied Microbiology and Biotechnology
https://www.readbyqxmd.com/read/29642408/mucormycosis-battle-with-the-deadly-enemy-over-a-five-year-period-in-india
#17
Jagdish Chander, Mandeep Kaur, Nidhi Singla, R P S Punia, Surinder K Singhal, Ashok K Attri, Ana Alastruey-Izquierdo, Alberto M Stchigel, Jose F Cano-Lira, Josep Guarro
Mucormycosis is an emerging opportunistic fungal infection. Increasing immunocompromization, widespread use of antibacterial and antifungal agents (such as voriconazole prophylaxis), carcinomas, transplantation and lifestyle diseases such as diabetes are the main contributors to this situation. The predominant clinical manifestations of mucormycosis vary from host to host, with rhino-orbital-cerebral, pulmonary, cutaneous, and gastrointestinal infections being the most common. In India, the prevalence of mucormycosis is approximately 0...
April 6, 2018: Journal of Fungi (Basel, Switzerland)
https://www.readbyqxmd.com/read/29627901/microbiological-quality-of-air-in-free-range-and-box-stall-stable-horse-keeping-systems
#18
Katarzyna Wolny-Koładka
The aim of this study was to assess the microbiological quality of air in three horse riding centers differing in the horse keeping systems. The air samples were collected in one facility with free-range horse keeping system and two with box stalls of different sizes. The samples were collected over a period of 3 years (2015-2017), four times per year (spring, summer, autumn, winter) to assess the effect of seasonal changes. The prevalence of aerobic mesophilic bacteria, mold fungi, actinomycetes, Staphylococcus spp...
April 7, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29619675/a-new-terpene-coumarin-microbial-transformed-by-mucor-polymorphosporus-induces-apoptosis-of-human-gastric-cancer-cell-line-mgc-803
#19
Guangzhi Li, Junchi Wang, Xiaojin Li, Jianguo Xu, Zhao Zhang, Jianyong Si
2'-Z auraptene (1) is a synthesized monoterpene coumarin with anticancer activity against human gastric cancer cells. In order to find new potential anticancer agent, Mucor polymorphosporus was used to transform cis-auraptene. Four new terpene coumarins with notable changes in the skeletal backbone, 2'-Z auraptene A-D (2-5), were obtained and evaluated for their antiproliferative effects against human normal gastric epithelium cells and human gastric cancer cells. These new compounds showed selective cytotoxic activity against MGC-803 cells with IC50 values from 0...
April 4, 2018: Archives of Pharmacal Research
https://www.readbyqxmd.com/read/29615990/the-role-of-strigolactone-in-the-cross-talk-between-arabidopsis-thaliana-and-the-endophytic-fungus-mucor-sp
#20
Piotr Rozpądek, Agnieszka M Domka, Michał Nosek, Rafał Ważny, Roman J Jędrzejczyk, Monika Wiciarz, Katarzyna Turnau
Over the last years the role of fungal endophytes in plant biology has been extensively studied. A number of species were shown to positively affect plant growth and fitness, thus attempts have been made to utilize these microorganisms in agriculture and phytoremediation. Plant-fungi symbiosis requires multiple metabolic adjustments of both of the interacting organisms. The mechanisms of these adaptations are mostly unknown, however, plant hormones seem to play a central role in this process. The plant hormone strigolactone (SL) was previously shown to activate hyphae branching of mycorrhizal fungi and to negatively affect pathogenic fungi growth...
2018: Frontiers in Microbiology
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