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Almudena Cascales, Florent Martinetti, Deborah Belemsagha, Cecile Le Pechoux
In the last 15 years, the use of Stereotactic Ablative Radiation Therapy (SABRT) in the management of small peripheral lung tumours has developed considerably, so that it currently represents a standard of care for inoperable stage I non-small cell lung cancer (NSCLC), offering a survival advantage over traditional radiotherapy, local control rates at 3 years around 90%, with a low risk of toxicity. Indications have extended to larger tumours up to 5 cm and centrally located tumours. In this review we will explore the role of SABRT in early stage NSCLC, the state of the art, the challenges and the future for this technique...
August 2014: Translational Lung Cancer Research
Joep Stroom, Sandra Vieira, Dalila Mateus, Carlo Greco, Antonella Fogliata, Giorgia Nicolini, Alessandro Clivio, Eugenio Vanetti, Luca Cozzi
BACKGROUND: To appraise the robustness of VMAT dose distributions against uncertainties in the positioning of the patients when single fraction SABRT treatments are planned. METHODS: A set of 18 patients (8 lung, 5 brain, 5 spinal or para-spinal) treated with VMAT in a single fraction of 24Gy were retrospectively analyzed. All approved plans were re-calculated by applying shifts to the isocentre of ±0.5, ±1, ±1.5, ±2 and ±3 mm along the primary X, Y and Z axes...
2014: Radiation Oncology
C Florescu, J Thariat
BACKGROUND: Median survival for recurrent/metastatic (unknown poly/oligometastatic status) head and neck cancer patients (HNSCC) is ten months with best systemic treatment. Metastatic ablation shows promising results in selected patients with several tumor types. We aimed to assess the role of surgery and stereotactic ablative body radiotherapy (SABR) with respect to survival in HNSCC. MATERIALS AND METHODS: Published data on metastatic HNSCC treated ablatively were analyzed...
July 2014: Critical Reviews in Oncology/hematology
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