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https://www.readbyqxmd.com/read/28806142/mucormycosis-pathogenesis-beyond-rhizopus
#1
Brad Spellberg
No abstract text is available yet for this article.
August 14, 2017: Virulence
https://www.readbyqxmd.com/read/28791562/production-of-fumaric-acid-by-bioconversion-of-corncob-hydrolytes-using-an-improved-rhizopus-oryzae-strain
#2
Xuefeng Wu, Qing Liu, Yongdong Deng, Xiaoju Chen, Zhi Zheng, Shaotong Jiang, Xingjiang Li
The use of microorganism fermentation for production of fumaric acid (FA), which is widely used in food, medicine, and other fields, can provide technical support for the FA industry. In this study, we aimed to increase the titer of FA production by using an improved Rhizopus oryzae WHT5, which was domesticated to obtain a furfural-resistant strain in corncob hydrolytes. The metabolic pathways and metabolic network of this strain were investigated, and the related enzymes and metabolic flux were analyzed. Metabolic pathway analysis showed that the R...
August 8, 2017: Applied Biochemistry and Biotechnology
https://www.readbyqxmd.com/read/28783439/mucorales-spores-induce-a-proinflammatory-cytokine-response-in-human-mononuclear-phagocytes-and-harbor-no-rodlet-hydrophobins
#3
Sebastian Wurster, Vanessa Thielen, Philipp Weis, Paul Walther, Johannes Elias, Ana Maria Waaga-Gasser, Mariola Dragan, Thomas Dandekar, Hermann Einsele, Jürgen Löffler, Andrew J Ullmann
Mucormycoses are life-threatening infections in immunocompromised patients. This study characterizes the response of human mononuclear cells to different Mucorales and Ascomycota. PBMC, monocytes, and monocyte derived dendritic cells (moDCs) from healthy donors were stimulated with resting and germinated stages of Mucorales and Ascomycota. Cytokine response and expression of activation markers were studied. Both inactivated germ tubes and resting spores of Rhizopus arrhizus and other human pathogenic Mucorales species significantly stimulated mRNA synthesis and secretion of proinflammatory cytokines...
August 7, 2017: Virulence
https://www.readbyqxmd.com/read/28762287/disease-resistance-to-multiple-fungal-and-oomycete-pathogens-evaluated-using-a-recombinant-inbred-line-population-in-pepper
#4
Rachel P Naegele, Leah L Granke, Jessica Fry, Theresa Hill, Hamid Ashrafi, Allen Van Deynze, Mary K Hausbeck
Incorporating disease resistance into cultivars is a primary focus of modern breeding programs. Resistance to pathogens is often introgressed from landrace or wild individuals with poor fruit quality into commercial-quality cultivars. Sites of multiple disease resistance (MDR) are regions or "hotspots" of the genome with closely linked genes for resistance to different pathogens that could enable rapid incorporation of resistance. An F2-derived F6 recombinant inbred line population from a cross between 'Criollo de Morelos 334' and 'Early Jalapeno' was evaluated in inoculated fruit studies for susceptibility to oomycete and fungal pathogens: Phytophthora capsici, P...
August 1, 2017: Phytopathology
https://www.readbyqxmd.com/read/28757006/-pulmonary-mucormycosis-in-a-patient-with-kidney-transplant-and-uncontrolled-haemoptysis
#5
Dulce Iliana Navarro Vergara, Gloria Barragán Pola, Alexandro Bonifaz, Carlos Núñez Pérez-Redondo, Omar Choreño García, Raúl Cicero Sabido
BACKGROUND: Pulmonary mucormycosis is a rare opportunistic infection with high mortality that is caused by species of Mucorales. The most common species involved are Rhizopus, Mucor, Lichtheimia, and Rhizomucor. CASE REPORT: A 56 year-old woman presented with a clinical history of diabetes mellitus type 2 and chronic renal disease. She underwent a cadaveric kidney transplantation two years before her admission, for which immunomodulating therapy with thymoglobulin, tacrolimus, mofetil-microphenolate and prednisone was established...
July 27, 2017: Revista Iberoamericana de Micología
https://www.readbyqxmd.com/read/28755328/alternaria-toxins-in-south-african-sunflower-seeds-cooperative-study
#6
Sebastian Hickert, Lena Hermes, Lucas Maciel Mauriz Marques, Christine Focke, Benedikt Cramer, Norberto Peporine Lopes, Bradley Flett, Hans-Ulrich Humpf
Sunflower seed samples (N = 80) from different sunflower cultivars originating from different localities in South Africa were analyzed for 15 toxins produced by fungi of the genus Alternaria by means of a simple one-step extraction dilute-and-shoot HPLC-MS/MS approach. References for valine-tenuazonic acid (Val-TeA), altenusin (ALTS), and altenuisol (ALTSOH) were isolated from fungal culture extracts and spectroscopically characterized. Additionally, valine-tenuazonic acid was tested regarding its cytotoxicity in comparison with tenuazonic acid (TeA) and showed less activity on HT-29 cells...
July 28, 2017: Mycotoxin Research
https://www.readbyqxmd.com/read/28752804/one-pot-conjugated-linoleic-acid-production-from-castor-oil-by-rhizopus-oryzae-lipase-and-resting-cells-of-lactobacillus-plantarum
#7
Abid Ali Khaskheli, Farah Naz Talpur, Aysun Cebeci Aydin, Sana Jawaid, Muhammad Ali Surhio, Hassan Imran Afridi
Conjugated linoleic acid (CLA) has attracted as novel type of fatty acids having unusual health-promoting properties such as anticarcinogenic and antiobesitic effects. The present work employed castor oil as substrate for one-pot production of CLA using washed cells of Lactobacillus plantarum (L. plantarum) and lipases as catalysts. Among the screened lipases, the lipase Rhizopus oryzae (ROL) greatly assisted resting cells to produce CLA. Mass spectral analysis of the product showed that two major isomers of CLA were produced in the reaction mixture i...
July 28, 2017: Bioscience, Biotechnology, and Biochemistry
https://www.readbyqxmd.com/read/28750194/ketoacidosis-alone-does-not-predispose-to-mucormycosis-by-lichtheimia-in-a-murine-pulmonary-infection-model
#8
Bianca Schulze, Günter Rambach, Volker U Schwartze, Kerstin Voigt, Katja Schubert, Cornelia Speth, Ilse D Jacobsen
Mucormycosis is a rare fungal infection; however, the number of cases increased during the last decades. The main risk factors are immunosuppression and uncontrolled diabetes mellitus. Although Lichtheimia species represent a common cause of mucormycosis in Europe, virulence and pathogenesis of this genus has not been investigated in detail yet. Using murine pulmonary infection models, we found that immunosuppression is essential for establishment of infection. The disease was characterized by necrosis, angioinvasion, thrombosis, and the lethal course of infection was associated with systemic activation of platelets...
July 27, 2017: Virulence
https://www.readbyqxmd.com/read/28747585/amylolytic-fungi-in-starter-cakes-for-rice-beer-production
#9
Arup Jyoti Das, Tatsuro Miyaji, Sankar Chandra Deka
Two types of starter cakes, viz. amou and perok-kushi, used in the production of rice beer in Assam, India, by the Bodo and Deori communities, respectively, were used for the isolation of amylolytic fungi. Based on the sequencing of their internal transcribed spacer (ITS) regions the fungi were identified as Amylomyces rouxii and Rhizopus oryzae, and given the strain names TU460 and TU465, respectively. Both the strains showed the ability to degrade and saccharify starch. The glucoamylase activity was considerably high in A...
July 27, 2017: Journal of General and Applied Microbiology
https://www.readbyqxmd.com/read/28714266/potential-biotechnological-capabilities-of-cultivable-mycobiota-from-carwash-effluents
#10
Timothy Sibanda, Ramganesh Selvarajan, Memory Tekere, Hlengilizwe Nyoni, Stephen Meddows-Taylor
Urban life has created man-made extreme environments like carwashes. These environments have, however, not been sufficiently explored for mycobiota that can be sources of biotechnologically useful products, as has been the case with natural extreme environments. Using a combination of culture and molecular techniques, fungi from carwash effluents was characterized for production of lipase and cellulase enzymes, nonpolar and polar biotechnologically relevant secondary metabolites and hydrocarbon utilization...
July 17, 2017: MicrobiologyOpen
https://www.readbyqxmd.com/read/28711611/biochemical-characterization-and-stability-assessment-of-rhizopus-oryzae-lipase-covalently-immobilized-on-amino-functionalized-magnetic-nanoparticles
#11
Kh Pashangeh, M Akhond, H R Karbalaei-Heidari, G Absalan
Amino-functionalized magnetic nanoparticles (Fe3O4) have been investigated as a support for covalent immobilization of lipase. The nanoparticles were prepared by chemical coprecipitation method and subsequently were coated with 3-aminopropyltriethoxysilane (APTES) via silanization reaction. With glutaraldehyde, as the coupling agent, the lipase from Rhizopus oryzae was successfully immobilized onto the amino-functionalized magnetic nanoparticles. The synthesized support was characterized by transmission electron microscopy and Fourier transform infrared spectroscopy...
July 12, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28711520/exploring-substrate-specificities-of-a-recombinant-rhizopus-oryzae-lipase-in-biodiesel-synthesis
#12
Albert Canet, M Dolors Benaiges, Francisco Valero, Patrick Adlercreutz
The alcoholysis of triolein was used to explore the specific features of a recombinant Rhizopus oryzae lipase (rROL) for biodiesel synthesis. For this purpose, different acylglycerols were compared as substrates in lipase-catalysed transesterification. rROL was shown to exhibit a higher specificity towards 1-monoolein than triolein compared to other R. oryzae lipases, being more than 4-fold more specific; in contrast, rROL did not accept 2-monoolein as substrate, concluding that it is highly 1,3-positional specific...
July 12, 2017: New Biotechnology
https://www.readbyqxmd.com/read/28702025/cellular-and-molecular-defects-underlying-invasive-fungal-infections-revelations-from-endemic-mycoses
#13
REVIEW
Pamela P Lee, Yu-Lung Lau
The global burden of fungal diseases has been increasing, as a result of the expanding number of susceptible individuals including people living with human immunodeficiency virus (HIV), hematopoietic stem cell or organ transplant recipients, patients with malignancies or immunological conditions receiving immunosuppressive treatment, premature neonates, and the elderly. Opportunistic fungal pathogens such as Aspergillus, Candida, Cryptococcus, Rhizopus, and Pneumocystis jiroveci are distributed worldwide and constitute the majority of invasive fungal infections (IFIs)...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/28685375/higher-in-vitro-proliferation-rate-of-rhizopus-oryzae-in-blood-of-diabetic-individuals-in-chronic-glycaemic-control-compared-with-non-diabetic-individuals
#14
Grace Salazar-Tamayo, Luis E López-Jácome, Jesús Resendiz-Sanchez, Rafael Franco-Cendejas, Patricia Rodriguez-Zulueta, Dora E Corzo-León
Metabolic control improves outcomes associated with mucormycosis. The aim of this study was to compare the in vitro proliferation of Rhizopus oryzae in blood of individuals with and without diabetes at different glycaemic levels. Ninety-five individuals were included. Blood samples from each participant were incubated with sporangiospores of R. oryzae. The germination, filamentation and growth of R. oryzae were compared at different time points. Four groups were defined, one without (group A, n = 30) and three with diabetes: group B (HbA1c ≤7%, N = 24), group C (HbA1c 7...
July 6, 2017: Mycopathologia
https://www.readbyqxmd.com/read/28681607/n-glycosylation-engineering-to-improve-the-constitutive-expression-of-rhizopus-oryzae-lipase-in-komagataella-phaffii
#15
Xiao-Wei Yu, Min Yang, Chuanhuan Jiang, Xiaofeng Zhang, Yan Xu
Our previous studies demonstrated that the N-glycans in Rhizopus chinensis lipase (RCL) was important for its secretion. In order to improve the secretion of Rhizopus oryzae lipase (ROL) under the control of the GAP promoter in Komagataella phaffii, two extra N-glycosylation sites were introduced in ROL according to the position of the N-glycosylation sites of RCL by sequence alignment. The results indicated that the secretion level of ROL was strongly improved by N-glycosylation engineering, and the highest value of extracellular enzyme activity was increased from 0...
July 26, 2017: Journal of Agricultural and Food Chemistry
https://www.readbyqxmd.com/read/28681022/aeromycological-analysis-of-allergenic-airborne-fungi-in-qazvin-iran
#16
S A Ghiasian, A H Maghsood, M R Aghamirian
BACKGROUND AND PURPOSE: Airborne fungi are one of the most important agents responsible for triggering allergicreactions such as rhinitis and severe asthma. This study was conducted to analyze and monitor the prevalence and distribution patterns of atmospheric fungal aerosols in the air of Qazvin during winter of 2012. MATERIALS AND METHODS: In the current descriptive study, the incidence and diversity of potentially allergenic airborne fungi were determined using two times sampling interval in 25 different locations of Qazvin city by Petri dish trappingtechnique and exposure of 10- cm diameter plates of Sabouraud's dextrose agar medium plus chloramphenicol to the air...
September 2016: Advances in Medical Mycology (Iran)
https://www.readbyqxmd.com/read/28673517/semi-continuous-production-of-high-activity-pectinases-by-immobilized-rhizopus-oryzae-using-tobacco-wastewater-as-substrate-and-their-utilization-in-the-hydrolysis-of-pectin-containing-lignocellulosic-biomass-at-high-solid-content
#17
REVIEW
Yu-Xi Zheng, Yuan-Liang Wang, Jun Pan, Jian-Rong Zhang, Ya Dai, Kun-Yan Chen
In this study, highly reactive endo- and exo-polygalacturonases (PGs) were produced from the tobacco industry wastewater using immobilized Rhizopus oryzae. Compared with free cells, immobilized cells increased enzyme activity 2.8-fold and reduced production time to 24h by shake-flask production. Moreover, the immobilized cells enabled the semi-continuous production of enzymes through repeated-batch mode for seven consecutive cycles in a scale-up bioreactor. During the first five cycles, the average endo-PG and exo-PG activities reached 307...
October 2017: Bioresource Technology
https://www.readbyqxmd.com/read/28662421/preparation-of-hydrolytic-liquid-from-dried-distiller-s-grains-with-solubles-and-fumaric-acid-fermentation-by-rhizopus-arrhizus-rh-7-13
#18
Huan Liu, Xuemin Yue, Yuhan Jin, Meng Wang, Li Deng, Fang Wang, Tianwei Tan
Fumaric acid production from lignocellulosic materials is an alternative chemicals production system. This work investigated the suitable conditions for hydrolysis of dried distiller's grains with solubles (DDGS). The hydrolytic liquid was subsequently used for the production of fumaric acid. After optimizing the hydrolysis conditions, the most suitable concentration of H2SO4 (2%), hydrolysis temperature (120 °C), hydrolysis time (100min) and solid/liquid ratio (1:10) were obtained. The yield of monosaccharides reached 258 mg/g DDGS and 15...
June 26, 2017: Journal of Environmental Management
https://www.readbyqxmd.com/read/28652241/prophylactic-treatment-with-vt-1161-protects-immunosuppressed-mice-from-rhizopus-arrhizus-var-arrhizus-infection
#19
Teclegiorgis Gebremariam, Sondus Alkhazraji, Lin Lin, Nathan P Wiederhold, Edward P Garvey, William J Hoekstra, Robert J Schotzinger, Thomas F Patterson, Scott G Filler, Ashraf S Ibrahim
We compared prophylactic or continuous therapy of the investigational drug VT-1161 to posaconazole in treating murine mucormycosis due to Rhizopus arrhizus var. arrhizus In the prophylaxis studies, only VT-1161 resulted in improved survival and lowered tissue fungal burden of immunosuppressed infected mice. In the continuous therapy, VT-1161 outperformed posaconazole in prolonging mice survival time despite their comparable effect in lowering tissue fungal burden. These results support the further development of VT-1161 against mucormycosis...
June 26, 2017: Antimicrobial Agents and Chemotherapy
https://www.readbyqxmd.com/read/28651077/rhizopus-oryzae-ancient-microbial-resource-with-importance-in-modern-food-industry
#20
REVIEW
Liliana Londoño-Hernández, Cristina Ramírez-Toro, Héctor A Ruiz, Juan A Ascacio-Valdés, Miguel A Aguilar-Gonzalez, Raúl Rodríguez-Herrera, Cristóbal N Aguilar
Filamentous fungi are microorganisms widely known for their diverse biochemical features. Fungi can efficiently invade a wide variety of substrates under operational conditions producing numerous bioproducts of interest, such as enzymes, organic acids, aromatic compounds and colorants. An additional interesting characteristic of some fungi is their safety classification for different uses, which guarantees that the bioproducts obtained from them do not contain any toxic component deleterious to humans. Rhizopus oryzae is among this group of fungi and is classified as a GRAS filamentous fungus, commonly used for production of some oriental traditional foods...
June 15, 2017: International Journal of Food Microbiology
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