keyword
https://read.qxmd.com/read/38535983/nutritional-profiling-fiber-content-and-in-vitro-bioactivities-of-wheat-based-biscuits-formulated-with-novel-ingredients
#1
JOURNAL ARTICLE
Marta Mesias, Francisco J Morales, Cristina Caleja, Tânia C S P Pires, Ricardo C Calhelha, Lillian Barros, Eliana Pereira
This study evaluated the nutritional profile and fiber content of innovative formulations of wheat-based biscuits enriched with chia seeds, carob flour and coconut sugar. The in vitro antioxidant, cytotoxic, anti-inflammatory and antimicrobial activities were also investigated to understand the potential health advantages of the incorporation of these new ingredients. The novel biscuits demonstrated significant improvements in protein and mineral content, with increases of 50% and 100% in chia biscuits, and up to 20% and 40% in carob biscuits, respectively...
March 27, 2024: Food & Function
https://read.qxmd.com/read/38535807/inhibition-of-aflatoxin-production-in-aspergillus-flavus-by-a-klebsiella-sp-and-its-metabolite-cyclo-l-ala-gly
#2
JOURNAL ARTICLE
Shohei Sakuda, Masaki Sunaoka, Maho Terada, Ayaka Sakoda, Natsumi Ishijima, Noriko Hakoshima, Kenichi Uchida, Hirofumi Enomoto, Tomohiro Furukawa
During an experiment where we were cultivating aflatoxigenic Aspergillus flavus on peanuts, we accidentally discovered that a bacterium adhering to the peanut strongly inhibited aflatoxin (AF) production by A. flavus . The bacterium, isolated and identified as Klebsiella aerogenes , was found to produce an AF production inhibitor. Cyclo(l-Ala-Gly), isolated from the bacterial culture supernatant, was the main active component. The aflatoxin production-inhibitory activity of cyclo(l-Ala-Gly) has not been reported...
March 8, 2024: Toxins
https://read.qxmd.com/read/38535576/-galleria-mellonella-as-a-model-for-the-study-of-fungal-pathogens-advantages-and-disadvantages
#3
REVIEW
Andrea Giammarino, Nicolò Bellucci, Letizia Angiolella
The study of pathogenicity and virulence of fungal strains, in vivo in the preclinical phase, is carried out through the use of animal models belonging to various classes of mammals (rodents, leproids, etc.). Although animals are functionally more similar to humans, these studies have some limitations in terms of ethics (animal suffering), user-friendliness, cost-effectiveness, timing (physiological response time) and logistics (need for adequately equipped laboratories). A good in vivo model must possess some optimal characteristics to be used, such as rapid growth, small size and short life cycle...
March 7, 2024: Pathogens
https://read.qxmd.com/read/38535459/new-phenol-derivatives-from-the-haima-cold-seep-derived-fungus-aspergillus-subversicolor-cyh-17
#4
JOURNAL ARTICLE
Yi-Hao Che, Wen-Ping Ding, Zhi-Hui Xiao, Jia-Min Wu, Hao Yin, Fa-Zuo Wang, Si Zhang
Seven new phenol derivatives, subversins A-E ( 1 - 5 ), subversic acid A ( 6 ) and epi -wortmannine G ( 7 ); one new natural product, 4-hydroxy-7-methoxyphthalide ( 8 ); and five known compounds ( 9 - 13 ) were isolated from the fungus Aspergillus subversicolor CYH-17 collected from the Haima cold seep. The structures and absolute configurations of these compounds were determined via NMR, MS, optical rotation, electronic circular dichroism (ECD) calculation, X-ray diffraction analysis and comparison with the literature...
February 29, 2024: Marine Drugs
https://read.qxmd.com/read/38535438/hydroxytakakiamide-and-other-constituents-from-a-marine-sponge-associated-fungus-aspergillus-fischeri-mmeru23-and-antinociceptive-activity-of-ergosterol-acetate-acetylaszonalenin-and-helvolic-acid
#5
JOURNAL ARTICLE
Harol Ricardo Arias Cardona, Bruno Cerqueira da Silva, Flávia Oliveira de Lima, Franco Henrique Andrade Leite, Bruno Cruz de Souza, Hugo Neves Brandão, Jorge Maurício David, Clayton Queiroz Alves, Anake Kijjoa
An unreported prenylated indole derivative hydroxytakakiamide ( 4 ) was isolated, together with the previously described ergosterol ( 1 ), ergosterol acetate ( 2 ), and (3 R )-3-(1 H -indol-3-ylmethyl)-3, 4-dihydro-1 H -1,4-benzodiazepine-2,5-dione ( 3 ), from the column fractions of the crude ethyl acetate extract of the culture of a marine sponge-associated fungus, Aspergillus fischeri MMERU 23. The structure of 4 was elucidated by the interpretation of 1D and 2D NMR spectral data and high-resolution mass spectrum...
February 20, 2024: Marine Drugs
https://read.qxmd.com/read/38535235/systemic-candida-infection-and-pulmonary-aspergillosis-in-an-alpaca-vicugna-pacos-a-case-report
#6
Andrea Grassi, Claudia Cafarchia, Nicola Decaro, Wafa Rhimi, Vittoriana De Laurentiis, Giulia D'Annunzio, Andrea Luppi, Paola Prati
This study reports a peculiar case of systemic candidiasis infection associated with pulmonary aspergillosis in an apparently immunocompetent alpaca. A captive 7-year-old female alpaca exhibited respiratory symptoms, underwent treatment with benzylpenicillin and dexamethasone, and succumbed to the infection 40 days later. During the post-mortem examination, subcutaneous emphysema, widespread pneumonia with multiple suppurative foci, scattered necro-suppurative lesions throughout the renal and hepatic parenchyma were evident...
March 20, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535229/the-oxidative-stress-response-highly-depends-on-glucose-and-iron-availability-in-aspergillus-fumigatus
#7
JOURNAL ARTICLE
Tamás Emri, Károly Antal, Kinga Varga, Barnabás Csaba Gila, István Pócsi
Pathogens have to cope with oxidative, iron- and carbon(glucose)-limitation stresses in the human body. To understand how combined iron-carbon limitation alters oxidative stress responses, Aspergillus fumigatus was cultured in glucose-peptone or peptone containing media supplemented or not with deferiprone as an iron chelator. Changes in the transcriptome in these cultures were recorded after H2 O2 treatment. Responses to oxidative stress were highly dependent on the availability of glucose and iron. Out of the 16 stress responsive antioxidative enzyme genes, only the cat2 catalase-peroxidase gene was upregulated in more than two culturing conditions...
March 18, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535227/new-vision-of-cell-walls-in-aspergillus-fumigatus-from-solid-state-nmr-spectroscopy
#8
REVIEW
Isha Gautam, Kalpana Singh, Malitha C Dickwella Widanage, Jayasubba Reddy Yarava, Tuo Wang
The fungal cell wall plays a critical role in regulating cellular integrity and communication, and serves as a frontline defense against stress. It is also a prime target for the development of antifungal agents. The cell wall is comprised of diverse polysaccharides and proteins and poses a challenging target for high-resolution structural characterization. Recently, the solid-state nuclear magnetic resonance (ssNMR) analysis of intact Aspergillus fumigatus cells has provided atomic-level insights into the structural polymorphism and functional assembly principles of carbohydrate components within the cell wall...
March 16, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535222/commercial-methods-for-antifungal-susceptibility-testing-of-saprophytic-molds-can-they-be-used-to-detect-resistance
#9
REVIEW
Paschalis Paranos, Ana Espinel-Ingroff, Joseph Meletiadis
Commercial tests are often employed in clinical microbiology laboratories for antifungal susceptibility testing of filamentous fungi. Method-dependent epidemiological cutoff values (ECVs) have been defined in order to detect non-wild-type (NWT) isolates harboring resistance mechanisms. We reviewed the literature in order to find studies where commercial methods were used to evaluate for in vitro susceptibility of filamentous fungi and assess their ability to detect NWT isolates according to the available ECVs...
March 14, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535218/importance-of-the-aspergillus-fumigatus-mismatch-repair-protein-msh6-in-antifungal-resistance-development
#10
JOURNAL ARTICLE
Jose Lucio, Irene Gonzalez-Jimenez, Alejandra Roldan, Jorge Amich, Laura Alcazar-Fuoli, Emilia Mellado
One of the systems responsible for the recognition and repair of mistakes occurring during cell replication is the DNA mismatch repair (MMR) system. Two major protein complexes constitute the MMR pathway: MutS and MutL. Here, we investigated the possible relation of four A. fumigatus MMR genes ( msh 2, msh 6, pms 1, and mlh 1) with the development of azole resistance related to the phenomenon of multi-drug resistance. We examined the MMR gene variations in 163 Aspergillus fumigatus genomes. Our analysis showed that genes msh 2, pms 1, and mlh 1 have low genetic variability and do not seem to correlate with drug resistance...
March 12, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535197/construction-of-a-cosmid-based-ultraefficient-genomic-library-system-for-filamentous-fungi-of-the-genus-aspergillus
#11
JOURNAL ARTICLE
Chihiro Kadooka, Takuji Oka
Filamentous fungi of the genus Aspergillus include producers of industrially important organic acids, enzymes, and secondary metabolites, as well as pathogens of many plants and animals. Novel genes in the Aspergillus genome are potentially crucial for the fermentation and drug industries (e.g., agrochemicals and antifungal drugs). A research approach based on classical genetics is effective for identifying functionally unknown genes. During analyses based on classical genetics, mutations must be identified easily and quickly...
February 29, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38535181/exploring-mechanisms-of-antifungal-lipopeptide-iturin-a-from-bacillus-against-aspergillus-niger
#12
JOURNAL ARTICLE
Shiyi Wang, Min Xu, Ye Han, Zhijiang Zhou
The control of Aspergillus niger ( A. niger ) is of great significance for the agricultural economy and food safety. In this study, the antifungal effect and mechanism of iturin A from Bacillus amyloliquefaciens (CGMCC No. 8473) against A. niger (ATCC 16404) were investigated using biochemical analyses and proteomics. Changes in a mycelium treated with iturin A were observed using scanning electron microscopy and transmission electron microscopy, including mycelial twisting and collapse, organelle disintegration, and intracellular vacuolization...
February 24, 2024: Journal of Fungi (Basel, Switzerland)
https://read.qxmd.com/read/38534634/fungal-endophthalmitis-clinical-characteristics-pathogens-and-factors-affecting-visual-outcome
#13
JOURNAL ARTICLE
Xiaoxia Li, Zhi Chen, Xiuwen Zhang, Zimei Zhou, Maureen Boost, Taomin Huang, Xingtao Zhou
AIMS: The aims of this study are to investigate the etiology, microbiological spectrum, and risk factors associated with visual outcomes of fungal endophthalmitis (FE) in a tertiary eye specialty hospital in Shanghai, China. METHODS: This was a retrospective, single-center case series. The clinical characteristics, etiology, microbiological spectrum, and management, as well as the visual outcomes, were analyzed. Logistic regression was used to analyze the factors related to visual outcomes...
February 20, 2024: Antibiotics
https://read.qxmd.com/read/38534459/the-effects-of-salinity-and-genotype-on-the-rhizospheric-mycobiomes-in-date-palm-seedlings
#14
JOURNAL ARTICLE
Mahmoud W Yaish, Aya Al-Busaidi, Bernard R Glick, Talaat Ahmed, Juha M Alatalo
Salinity severely affects the health and productivity of plants, with root-associated microbes, including fungi, potentially playing a crucial role in mitigating this effect and promoting plant health. This study employed metagenomics to investigate differences in the structures of the epiphyte mycobiomes in the rhizospheres of seedlings of two distinct date palm cultivars with contrasting salinity tolerances, the susceptible cultivar, 'Zabad', and the tolerant cultivar, 'Umsila'. Next-generation sequencing (NGS) of the internal transcribed spacer (ITS) rRNA was utilized as a DNA barcoding tool...
March 15, 2024: Biology
https://read.qxmd.com/read/38534388/grafted-sertoli-cells-exert-immunomodulatory-non-immunosuppressive-effects-in-preclinical-models-of-infection-and-cancer
#15
JOURNAL ARTICLE
Sara Chiappalupi, Laura Salvadori, Monica Borghi, Francesca Mancuso, Marilena Pariano, Francesca Riuzzi, Giovanni Luca, Luigina Romani, Iva Arato, Guglielmo Sorci
The Sertoli cells (SeCs) of the seminiferous tubules secrete a multitude of immunoregulatory and trophic factors to provide immune protection and assist in the orderly development of germ cells. Grafts of naked or encapsulated SeCs have been proved to represent an interesting therapeutic option in a plethora of experimental models of diseases. However, whether SeCs have immunosuppressive or immunomodulatory effects, which is imperative for their clinical translatability, has not been demonstrated. We directly assessed the immunopotential of intraperitoneally grafted microencapsulated porcine SeCs (MC-SeCs) in murine models of fungal infection ( Aspergillus fumigatus or Candida albicans ) or cancer (Lewis lung carcinoma/LLC or B16 melanoma cells)...
March 19, 2024: Cells
https://read.qxmd.com/read/38534143/triazole-resistance-in-aspergillus-fumigatu-s-isolated-from-a-tomato-production-environment-exposed-to-propiconazole
#16
JOURNAL ARTICLE
Alejandra M Jimenez Madrid, Raees A Paul, Francesca Rotondo, Loic Deblais, Gireesh Rajashekara, Sally A Miller, Melanie L Lewis Ivey
UNLABELLED: The emergence of azole-resistant Aspergillus fumigatus (AR Af ) across the world is an important public health concern. We sought to determine if propiconazole, a demethylase inhibitor (DMI) fungicide, exerted a selective pressure for AR Af in a tomato production environment following multiple exposures to the fungicide. A tomato field trial was established in 2019 and propiconazole was applied weekly until harvest. Soil, leaf, and fruit (when present) samples were collected at baseline and after each propiconazole application...
March 27, 2024: Applied and Environmental Microbiology
https://read.qxmd.com/read/38534106/mycoremediation-of-the-novel-fungicide-ametoctradin-by-different-agricultural-soils-and-accelerated-degradation-utilizing-selected-fungal-strains
#17
JOURNAL ARTICLE
Sara Majid, Khuram Shahzad Ahmad, Ghulam Abbas Ashraf, Wahidah H Al-Qahtani
Accelerating safety assessments for novel agrochemicals is imperative, advocating for in vitro setups to present pesticide biodegradation by soil microbiota before field studies. This approach enables metabolic profile generation in a controlled laboratory environment eliminating extrinsic factors. In the current study, ten different soil samples were utilized to check their capability to degrade Ametoctradin by their microbiota. Furthermore, five different fungal strains ( Aspergillus niger , Aspergillus flavus , Aspergillus fumigatus, Lasiodiplodia theobromae , and Penicillium chrysogenum ) were utilized to degrade Ametoctradin in aqueous media...
March 27, 2024: Journal of Environmental Science and Health. Part. B, Pesticides, Food Contaminants, and Agricultural Wastes
https://read.qxmd.com/read/38533933/data-mining-and-safety-analysis-of-traditional-immunosuppressive-drugs-a-pharmacovigilance-investigation-based-on-the-faers-database
#18
JOURNAL ARTICLE
Juan-Juan Li, Li Chen, Yang Zhao, Xue-Qin Yang, Fa-Bin Hu, Li Wang
OBJECTIVE: The purpose of this study aimed to explore the new and serious adverse events(AEs) of Tacrolimus(FK506), cyclosporine(CsA), azathioprine(AZA), mycophenolate mofetil(MMF), cyclophosphamide(CTX) and methotrexate(MTX), which have not been concerned. METHODS: The FAERS data from January 2016 and December 2022 were selected for disproportionality analysis to discover the potential risks of traditional immunosuppressive drugs. RESULTS: Compared with CsA, FK506 has more frequent transplant rejection, and is more related to renal impairment, COVID-19, cytomegalovirus infection and aspergillus infection...
March 27, 2024: Expert Opinion on Drug Safety
https://read.qxmd.com/read/38533468/production-of-non-natural-5-methylorsellinate-derived-meroterpenoids-in-aspergillus-oryzae
#19
JOURNAL ARTICLE
Jia Tang, Yixiang Zhang, Yudai Matsuda
Fungal meroterpenoids are diverse structurally intriguing molecules with various biological properties. One large group within this compound class is derived from the aromatic precursor 3,5-dimethylorsellinic acid (DMOA). In this study, we constructed engineered metabolic pathways in the fungus Aspergillus oryzae to expand the molecular diversity of meroterpenoids. We employed the 5-methylorsellinic acid (5-MOA) synthase FncE and three additional biosynthetic enzymes for the formation of (6 R ,10' R )-epoxyfarnesyl-5-MOA methyl ester, which served as a non-native substrate for four terpene cyclases from DMOA-derived meroterpenoid pathways...
2024: Beilstein Journal of Organic Chemistry
https://read.qxmd.com/read/38533339/endophytic-aspergillus-hiratsukae-mediated-biosynthesis-of-silver-nanoparticles-and-their-antimicrobial-and-photocatalytic-activities
#20
JOURNAL ARTICLE
Ebrahim Saied, Mostafa A Abdel-Maksoud, Akram A Alfuraydi, Bushra Hafeez Kiani, Mohamed Bassyouni, Osama A Al-Qabandi, Fathia H E Bougafa, Mona Shaban E M Badawy, Amr H Hashem
In the current study, endophytic Aspergillus hiratsukae was used for the biosynthesis of silver nanoparticles (Ag-NPs) for the first time. The characterizations were performed using X ray diffraction (XRD), Transmission electron microscopy (TEM), Scanning electron microscopy with energy dispersive X-ray spectroscopy (SEM-EDX), Dynamic light scattering (DLS), Fourier transform infrared spectroscopy (FT-IR), and UV-Vis spectroscopy. The obtained results demonstrated the successful formation of crystalline, spherical Ag-NPs with particle diameters ranging from 16 to 31 nm...
2024: Frontiers in Microbiology
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