keyword
MENU ▼
Read by QxMD icon Read
search

Childhood Development

keyword
https://www.readbyqxmd.com/read/28329526/chronic-granulomatous-disease-as-a-risk-factor-for-cutaneous-lupus-in-childhood
#1
Sandrina Carvalho, Susana Machado, Rita Sampaio, Margarida Guedes, Júlia Vasconcelos, Diogo Semedo, Manuela Selores
Chronic granulomatous disease (CGD) is a primaryimmunodeficiency disorder that affects the phagocyticcells of the innate immune system. It is characterizedby recurrent or persistent infections with granulomaformation. Lupus-like lesions have been reported incarriers of CGD and less frequently, in patients withCGD. Immunological study in these patients areusually negative. We describe the case of an 8-yearoldboy with CGD who developed chronic and acutecutaneous lupus erythematous with angular cheilitis,oral ulcers, Raynaud phenomenon, and positiveserologies for antinuclear, anticentromere, and anti-Saccharomyces cerevisiae antibodies...
March 15, 2017: Dermatology Online Journal
https://www.readbyqxmd.com/read/28328688/prioritizing-the-care-of-critically-ill-children-in-south-africa-how-does-screen-perform-against-other-triage-tools
#2
Bhakti Hansoti, Peter Hodkinson, Lee Wallis
OBJECTIVE: Childhood mortality remains unacceptably high. In low-resource settings, children with critical illness often present for care. Current triage strategies are time consuming and require trained health care workers. To address this limitation, our team developed a simple subjective tool, SCREEN (Sick Children Require Emergency Evaluation Now), which is easy to administer, to identify critically ill children. This article presents the development of the SCREEN program and evaluates its performance when compared with other commonly implemented triage tools in low-resource settings...
March 21, 2017: Pediatric Emergency Care
https://www.readbyqxmd.com/read/28328125/two-patients-with-the-heterozygous-r189h-mutation-in-acta2-and-complex-congenital-heart-defects-expands-the-cardiac-phenotype-of-multisystemic-smooth-muscle-dysfunction-syndrome
#3
Thushiha Logeswaran, Christoph Friedburg, Karoline Hofmann, Hakan Akintuerk, Saskia Biskup, Michael Graef, Ali Rad, Axel Weber, Bernd A Neubauer, Dietmar Schranz, Patrice Bouvagnet, Birgit Lorenz, Andreas Hahn
De novo heterozygous mutations changing R179 to histidine, leucine, or cysteine in the ACTA2 gene are associated with Multisystemic Smooth Muscle Dysfunction Syndrome (MSMDS). Characteristic hallmarks of this condition, caused only by these specific ACTA2 mutations, are congenital mydriasis (mid-dilated, non-reactive pupils), a large persistent ductus arteriosus (PDA), aortic aneurysms evolving during childhood, and cerebrovascular anomalies. We describe two patients, a 3-day-old newborn and a 26-year-old woman, with this unique mutation in association with a huge PDA and an aorto-pulmonary window...
April 2017: American Journal of Medical Genetics. Part A
https://www.readbyqxmd.com/read/28327823/ex-vivo-model-of-rabbit-intestinal-epithelium-applied-to-the-study-of-colonization-by-enteroaggregative-escherichia-coli
#4
Ricardo Luís Lopes Braga, Ana Claudia Machado Pereira, Paula Azevedo Dos Santos, Angela Corrêa Freitas-Almeida, Ana Cláudia de Paula Rosa
BACKGROUND: The diarrheal syndrome is considered a serious public health problem all over the world and is considered a major cause of morbidity and mortality in developing countries. The high incidence of enteroaggregative Escherichia coli in diarrheal syndromes classified as an emerging pathogen of gastrointestinal infections. After decades of study, your pathogenesis remains uncertain and has been investigated mainly using in vitro models of adhesion in cellular lines. OBJECTIVE: The present study investigated the interaction of enteroaggregative Escherichia coli strains isolated from childhood diarrhea with rabbit ileal and colonic mucosa ex vivo, using the in vitro organ culture model...
March 16, 2017: Arquivos de Gastroenterologia
https://www.readbyqxmd.com/read/28327118/sociodemographic-and-delivery-risk-factors-for-developing-postpartum-depression-in-a-sample-of-3233-mothers-from-the-czech-elspac-study
#5
Adam Fiala, Jan Švancara, Jana Klánová, Tomáš Kašpárek
BACKGROUND: In the postpartum period, certain groups of women are at a higher risk for developing depressive episodes. Several studies have described risk factors for developing postpartum depression (PPD). However, these studies have used limited numbers of participants, and therefore the estimated prevalence of PPD varies greatly. METHODS: The objective of this study is to identify the main risk factors for developing PPD by using data collected via the Czech version of the European Longitudinal Study of Pregnancy and Childhood (ELSPAC)...
March 21, 2017: BMC Psychiatry
https://www.readbyqxmd.com/read/28327104/characterizing-early-child-growth-patterns-of-height-for-age-in-an-urban-slum-cohort-of-bangladesh-with-functional-principal-component-analysis
#6
Yin Zhang, Jianhui Zhou, Feiyang Niu, Jeffrey R Donowitz, Rashidul Haque, William A Petri, Jennie Z Ma
BACKGROUND: Early childhood is a critical stage of physical and cognitive growth that forms the foundation of future wellbeing. Stunted growth is presented in one of every 4 children worldwide and contributes to developmental impairment and under-five mortality. Better understanding of early growth patterns should allow for early detection and intervention in malnutrition. We aimed to characterize early child growth patterns and quantify the change of growth curves from the World Health Organization (WHO) Child Growth Standards...
March 21, 2017: BMC Pediatrics
https://www.readbyqxmd.com/read/28326824/osteopontin-its-potential-role-in-cancer-of-children-and-young-adults
#7
Gabrielle Karpinsky, Aleksandra Fatyga, Malgorzata Anna Krawczyk, Madeleine Chamera, Natalia Sande, Dagmara Szmyd, Ewa Izycka-Swieszewska, Ewa Bien
OBJECTIVE: Osteopontin (OPN) is aglyco-phosphoprotein, involved in tissue remodeling, inflammation and boneresorption. In various adult neoplasms OPN was shown to correlate with cancer progression, invasiveness and metastasis. AIM: to define the role of OPN in malignancies of children and young adults. MATERIAL AND METHODS: a structured PubMed and Google Scholar literature analysis based on reports published in English between I'1995 and XII'2015...
March 14, 2017: Biomarkers in Medicine
https://www.readbyqxmd.com/read/28326741/the-impact-of-childhood-adversities-on-anxiety-and-depressive-disorders-in-adulthood
#8
(no author information available yet)
OBJECTIVES: The childhood adversities model is generally accepted as a predictor of adult psychopathology vulnerability. It stems from child development theories, but the question remains as of how well solid research supports it. The aim of this article is to give a review of the studies concerning childhood adversities and their impact on the development of anxiety disorders and major depressive disorder in adulthood. METHOD: A computerized search of the MEDLINE database of publications up to 31 March 2016 was done, using the keywords "childhood adversities, abuse, maltreatment, bullying" and "anxiety disorders, depressive disorder"...
December 22, 2016: Neuro Endocrinology Letters
https://www.readbyqxmd.com/read/28326654/the-development-of-bodily-self-consciousness-changing-responses-to-the-full-body-illusion-in-childhood
#9
Dorothy Cowie, Aisling McKenna, Andrew J Bremner, Jane E Aspell
The present work investigates the development of bodily self-consciousness and its relation to multisensory bodily information, by measuring for the first time the development of responses to the full body illusion in childhood. We tested three age groups of children: 6- to 7-year-olds (n = 28); 8- to 9-year-olds (n = 21); 10- to 11-year-olds (n = 19), and a group of adults (n = 31). Each participant wore a head-mounted display (HMD) which displayed a view from a video camera positioned 2 metres behind their own back...
March 22, 2017: Developmental Science
https://www.readbyqxmd.com/read/28326536/risk-factors-for-obesity-in-preschool-aged-children-in-china
#10
Jyu-Lin Chen, Jill Howie Esquivel, Jia Guo, Catherine A Chesla, Siyuan Tang
AIMS: To examine the relationship between child, mother, and environmental factors and increased body mass index in preschool-aged children in China. BACKGROUND: There are about 120 million children in China are classified as overweight or obese. Understanding the key factors associated with childhood obesity (i.e. child, mother and environment) is the first step in combating the growing obesity epidemic in China, as well as in the global community, where large numbers of Chinese immigrants can be found...
March 21, 2017: International Nursing Review
https://www.readbyqxmd.com/read/28326533/dysregulated-fear-social-inhibition-and-respiratory-sinus-arrhythmia-a%C3%A2-replication-and-extension
#11
Kristin A Buss, Elizabeth L Davis, Nilam Ram, Michael Coccia
Behavioral inhibition indicates increased risk for development of social anxiety. Recent work has identified a pattern of dysregulated fear (DF), characterized by high fear in low-threat situations, that provides a more precise marker of developmental risk through early childhood. This study tested a new longitudinal sample of children (n = 124) from ages 24 to 48 months. Replicating prior findings, at 24 months, we identified a pattern of fearful behavior across contexts marked by higher fear to putatively low-threat situations...
March 21, 2017: Child Development
https://www.readbyqxmd.com/read/28326160/the-neural-correlates-of-childhood-maltreatment-and-the-ability-to-understand-mental-states-of-others
#12
Charlotte C van Schie, Anne-Laura van Harmelen, Kirsten Hauber, Albert Boon, Eveline A Crone, Bernet M Elzinga
Background: Emotional abuse and emotional neglect are related to impaired interpersonal functioning. One underlying mechanism could be a developmental delay in mentalizing, the ability to understand other people's thoughts and emotions. Objective: This study investigates the neural correlates of mentalizing and the specific relationship with emotional abuse and neglect whilst taking into account the level of sexual abuse, physical abuse and physical neglect. Method: The RMET was performed in an fMRI scanner by 46 adolescents (Age: M = 18...
2017: European Journal of Psychotraumatology
https://www.readbyqxmd.com/read/28325298/relevance-of-fusion-genes-in-pediatric-cancers-toward-precision-medicine
#13
REVIEW
Célia Dupain, Anne Catherine Harttrampf, Giorgia Urbinati, Birgit Geoerger, Liliane Massaad-Massade
Pediatric cancers differ from adult tumors, especially by their very low mutational rate. Therefore, their etiology could be explained in part by other oncogenic mechanisms such as chromosomal rearrangements, supporting the possible implication of fusion genes in the development of pediatric cancers. Fusion genes result from chromosomal rearrangements leading to the juxtaposition of two genes. Consequently, an abnormal activation of one or both genes is observed. The detection of fusion genes has generated great interest in basic cancer research and in the clinical setting, since these genes can lead to better comprehension of the biological mechanisms of tumorigenesis and they can also be used as therapeutic targets and diagnostic or prognostic biomarkers...
March 17, 2017: Molecular Therapy. Nucleic Acids
https://www.readbyqxmd.com/read/28324701/stress-reactivity-and-its-effects-on-subsequent-food-intake-in-depressed-and-healthy-women-with-and-without-adverse-childhood-experiences
#14
Katja Wingenfeld, Linn K Kuehl, Anita Boeker, Katharina Schultebraucks, Kristin Ritter, Julian Hellmann-Regen, Christian Otte, Carsten Spitzer
BACKGROUND: Adverse childhood experiences (ACE) increase the risk to develop major depressive disorder (MDD) and obesity or metabolic syndrome in adulthood. In addition, ACE may be associated with an exaggerated endocrine response to stress, which, in turn, may lead to enhanced food intake resulting in obesity and metabolic problems. METHODS: We systematically examined the stress response and consecutive food intake in 32 women with MDD and ACE as determined by a clinical interview (Early Trauma Inventory), 52 women with MDD without ACE, 22 women with ACE but no current or lifetime MDD and 37 healthy women without either MDD or ACE...
March 12, 2017: Psychoneuroendocrinology
https://www.readbyqxmd.com/read/28322222/white-matter-maturation-is-associated-with-the-emergence-of-theory-of-mind-in-early-childhood
#15
Charlotte Grosse Wiesmann, Jan Schreiber, Tania Singer, Nikolaus Steinbeis, Angela D Friederici
The ability to attribute mental states to other individuals is crucial for human cognition. A milestone of this ability is reached around the age of 4, when children start understanding that others can have false beliefs about the world. The neural basis supporting this critical step is currently unknown. Here, we relate this behavioural change to the maturation of white matter structure in 3- and 4-year-old children. Tract-based spatial statistics and probabilistic tractography show that the developmental breakthrough in false belief understanding is associated with age-related changes in local white matter structure in temporoparietal regions, the precuneus and medial prefrontal cortex, and with increased dorsal white matter connectivity between temporoparietal and inferior frontal regions...
March 21, 2017: Nature Communications
https://www.readbyqxmd.com/read/28321885/molecular-analysis-of-norovirus-in-specimens-from-children-enrolled-in-a-1982-1986-study-in-bel%C3%A3-m-brazil-a-community-based-longitudinal-study
#16
Jones Anderson Monteiro Siqueira, Edivaldo Costa Sousa Júnior, Alexandre da Costa Linhares, Yvone Benchimol Gabbay
Fecal specimens were collected during a longitudinal, community-based study in the city of Belém, North Brazil, that was conducted over 3 years (October 1982 to March 1986), in which 20 children were included from birth to 3 years of age. A total of 229 fecal samples were screened by real time RT-PCR targeting the junction region (ORF 1/2) of the norovirus (NoV) genome. NoV-positive samples were subjected to PCR and sequencing of the viral polymerase (ORF1) and viral protein 1 (VP1) genes (ORF2). The junction region was also sequenced to assess for recombination when ORF1 and ORF2 genotyping results were dissimilar...
March 20, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28320465/reduced-microbial-diversity-in-adult-survivors-of-childhood-acute-lymphoblastic-leukemia-and-microbial-associations-with-increased-immune-activation
#17
Ling Ling Chua, Reena Rajasuriar, Mohamad Shafiq Azanan, Noor Kamila Abdullah, Mei San Tang, Soo Ching Lee, Yin Ling Woo, Yvonne Ai Lian Lim, Hany Ariffin, P'ng Loke
BACKGROUND: Adult survivors of childhood cancers such as acute lymphoblastic leukemia (ALL) have health problems that persist or develop years after cessation of therapy. These late effects include chronic inflammation-related comorbidities such as obesity and type 2 diabetes, but the underlying cause is poorly understood. RESULTS: We compared the anal microbiota composition of adult survivors of childhood ALL (N = 73) with healthy control subjects (N = 61)...
March 20, 2017: Microbiome
https://www.readbyqxmd.com/read/28320411/human-rotavirus-strains-circulating-in-venezuela-after-vaccine-introduction-predominance-of-g2p-4-and-reemergence-of-g1p-8
#18
Esmeralda Vizzi, Oscar A Piñeros, M Daniela Oropeza, Laura Naranjo, José A Suárez, Rixio Fernández, José L Zambrano, Argelia Celis, Ferdinando Liprandi
BACKGROUND: Rotavirus (RV) is the most common cause of severe childhood diarrhea worldwide. Despite Venezuela was among the first developing countries to introduce RV vaccines into their national immunization schedules, RV is still contributing to the burden of diarrhea. Concerns exist about the selective pressure that RV vaccines could exert on the predominant types and/or emergence of new strains. RESULTS: To assess the impact of RV vaccines on the genotype distribution 1 year after the vaccination was implemented, a total of 912 fecal specimens, collected from children with acute gastroenteritis in Caracas from February 2007 to April 2008, were screened, of which 169 (18...
March 21, 2017: Virology Journal
https://www.readbyqxmd.com/read/28320408/factors-of-physical-activity-among-chinese-children-and-adolescents-a-systematic-review
#19
REVIEW
Congchao Lu, Ronald P Stolk, Pieter J J Sauer, Anna Sijtsma, Rikstje Wiersma, Guowei Huang, Eva Corpeleijn
BACKGROUND: Lack of physical activity is a growing problem in China, due to the fast economic development and changing living environment over the past two decades. The aim of this review is to summarize the factors related to physical activity in Chinese children and adolescents during this distinct period of development. METHODS: A systematic search was finished on Jan 10(th), 2017, and identified 2200 hits through PubMed and Web of Science. English-language published studies were included if they reported statistical associations between factors and physical activity...
March 21, 2017: International Journal of Behavioral Nutrition and Physical Activity
https://www.readbyqxmd.com/read/28320319/cytomegalovirus-epstein-barr-virus-and-varicella-zoster-virus-infection-in-the-first-two-years-of-life-a-cohort-study-in-bradford-uk
#20
Lucy Pembrey, Dagmar Waiblinger, Paul Griffiths, Mauli Patel, Rafaq Azad, John Wright
BACKGROUND: Cytomegalovirus (CMV), Epstein Barr virus (EBV) and varicella-zoster virus (VZV) are common herpesviruses frequently acquired in childhood, which establish persistent, latent infection and are likely to impact the developing immune system. Little is known about the epidemiology of CMV and EBV infections in contemporary UK paediatric populations, particularly whether age at infection differs by ethnic group. METHODS: Children enrolled in the Born in Bradford Allergy and Infection Study had a blood sample taken and a questionnaire completed at 12 and 24 months of age...
March 21, 2017: BMC Infectious Diseases
keyword
keyword
23205
1
2
Fetch more papers »
Fetching more papers... Fetching...
Read by QxMD. Sign in or create an account to discover new knowledge that matter to you.
Remove bar
Read by QxMD icon Read
×

Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"