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Plant extract and cancer

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https://www.readbyqxmd.com/read/29053343/efficiency-of-opuntia-ficus-in-the-phytoremediation-of-a-soil-contaminated-with-used-motor-oil-and-lead-compared-to-that-of-lolium-perenne-and-aloe-barbadendis
#1
Luisa F Escobar-Alvarado, Mabel Vaca-Mier, Raymundo López-Callejas, Ma Neftalí Rojas-Valencia
Industrial pollutants such as heavy metals and hydrocarbons in soils represent a serious concern due to their persistence and negative effects on the environment, affecting cellular processes in living organisms and even causing mutations and cancer. The main objectives of this work were to evaluate the efficiency of Opuntia ficus in the phytoremediation of a soil polluted with used motor oil. Two other species, one with different and one with similar characteristics, relatively, were used for comparison purposes: Lolium perenne and Aloe barbadensis...
October 20, 2017: International Journal of Phytoremediation
https://www.readbyqxmd.com/read/29053266/structure-activity-relationships-of-new-natural-product-based-diaryloxazoles-with-selective-activity-against-androgen-receptor-positive-breast-cancer-cells
#2
Andrew J Robles, Shelby McCowen, Shengxin Cai, Michaels Glassman, Francisco Ruiz, Robert H Cichewicz, Stanton F McHardy, Susan L Mooberry
Targeted therapies for ER+/PR+ and HER2-amplified breast cancers have improved patient survival, but there are no therapies for triple negative breast cancers (TNBC) that lack expression of estrogen and progesterone receptors (ER/PR), or amplification or overexpression of HER2. Gene expression profiling of TNBC has identified molecular subtypes and representative cell lines. An extract of the Texas native plant Amyris texana was found to have selective activity against MDA-MB-453 cells, a model of the luminal androgen receptor (LAR) subtype of TNBC...
October 20, 2017: Journal of Medicinal Chemistry
https://www.readbyqxmd.com/read/29045235/the-aqueous-tuber-extract-of-pueraria-tuberosa-willd-d-c-caused-cytotoxic-effect-on-ht-29-cell-lines-with-down-regulation-of-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb
#3
Adeolu Alex Adedapo, Olusegun A Fagbohun, Christianah Dawurung, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Momoh Audu Yakubu
Background Pueraria tuberosa (Willd) D.C. (Fabaceae) tubers are already used in traditional medicine by Ayurvedic physicians for the management of fertility disorders, general weakness, and also as anti-ageing therapies. Other known pharmacological properties include: anti-hyperglycemics, hepatoprotective, anti-hyperlipidemic, diuretic, nutritive, and anti-fertility agents in male rats. Methods The anti-proliferative effect of the aqueous tuberous root extract of Pueraria tuberosa on vascular smooth muscle cells (VSMCs) and Human Colorectal Adenocarcinoma Cell lines (HT-29) was investigated using the Cell Titer 96 MTT Proliferation Assay where the viable cells were seeded at a density of 5 × 104 (100 µL/well)...
October 18, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29040016/centella-asiatica-fraction-3-suppresses-the-nuclear-factor-erythroid-2-related-factor-2-anti-oxidant-pathway-and-enhances-reactive-oxygen-species-mediated-cell-death-in-cancerous-lung-a549-cells
#4
Dhaneshree Bestinee Naidoo, Alisa Phulukdaree, Krishnan Anand, Vikash Sewram, Anil Amichund Chuturgoon
Centella asiatica is a tropical medicinal plant that is commonly used in traditional medicine. Medicinal properties of C. asiatica include anti-oxidant, anti-inflammatory, and anti-cancer activity. We investigated the anti-oxidant and anti-proliferative/cytotoxic effects of a semi-purified fraction of C. asiatica ethanolic leaf extract (C3) in cancerous lung A549 cells. C3 was obtained by silica column fractionation and identified by using thin-layer chromatography and gas chromatography mass spectrometry. Cytotoxicity of C3 in A549 cells was evaluated (cell viability assay-WST-1; 24 h; [0...
October 2017: Journal of Medicinal Food
https://www.readbyqxmd.com/read/29039333/antioxidant-antibacterial-and-antiproliferative-activities-of-pumpkin-cucurbit-peel-and-puree-extracts-an-in-vitro-study
#5
Muhammad Asif, Syed Ali Raza Naqvi, Tauqir A Sherazi, Matloob Ahmad, Ameer Fawad Zahoor, Sohail Anjum Shahzad, Zaib Hussain, Hassan Mahmood, Nasir Mahmood
Natural resources right from the beginning of the human civilization has paved the way to human being to combat different challenges. The big challenge was to safe the human being from diseases and shortage of food. Plants helped the man in both areas very efficiently. No doubt when plants are used as food actually we are also taking lot of compounds of medicinal values in an excellent combination which naturally reduce the risk of diseases. Extraction and purification of several medicinally important compounds also gave the way to develop pharmaceutical industry in addition to its own therapeutic effects against different lethal diseases...
July 2017: Pakistan Journal of Pharmaceutical Sciences
https://www.readbyqxmd.com/read/29037704/comparison-of-the-effect-of-chemical-composition-of-anthocyanin-rich-plant-extracts-on-colon-cancer-cell-proliferation-and-their-potential-mechanism-of-action-using-in-vitro-in-silico-and-biochemical-assays
#6
Candice Mazewski, Katie Liang, Elvira Gonzalez de Mejia
The objective was to compare the anti-proliferative effect of anthocyanin-rich plant extracts on human colon cancer cells and determine their mechanism of action. Eleven extracts were tested: red (RG) and purple grape, purple sweet potato, purple carrot, black and purple bean, black lentil (BL), black peanut, sorghum (SH), black rice, and blue wheat. HCT-116 and HT-29 inhibition correlated with total phenolics (r=0.87 and 0.77, respectively), delphinidin-3-O-glucoside concentration with HT-29 inhibition (r=0...
March 1, 2018: Food Chemistry
https://www.readbyqxmd.com/read/29036902/dna-adducts-formed-by-aristolochic-acid-are-unique-biomarkers-of-exposure-and-explain-the-initiation-phase-of-upper-urothelial-cancer
#7
REVIEW
Marie Stiborová, Volker M Arlt, Heinz H Schmeiser
Aristolochic acid (AA) is a plant alkaloid that causes aristolochic acid nephropathy (AAN) and Balkan endemic nephropathy (BEN), unique renal diseases frequently associated with upper urothelial cancer (UUC). This review summarizes the significance of AA-derived DNA adducts in the aetiology of UUC leading to specific A:T to T:A transversion mutations (mutational signature) in AAN/BEN-associated tumours, which are otherwise rare in individuals with UCC not exposed to AA. Therefore, such DNA damage produced by AA-DNA adducts is one rare example of the direct association of exposure and cancer development (UUC) in humans, confirming that the covalent binding of carcinogens to DNA is causally related to tumourigenesis...
October 14, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/29027024/studies-on-the-constituents-of-helleborus-purpurascens-analysis-and-biological-activity-of-the-aqueous-and-organic-extracts
#8
M Heiko Franz, Roxana Birzoi, Catalin-Vasile Maftei, Elena Maftei, Gerhard Kelter, Heinz-Herbert Fiebig, Ion Neda
In Southeast Europe, the ethnomedicinal use of Helleborus species has a very long tradition. Cardiac steroids (Hellebrin), cysteine-rich proteins (Hellethionins) and several steroidal saponins have been identified in these plants. Aim of the present work was to investigate the amino acid composition of native extracts from the root and rootstock of Helleborus purpurascens. The amino acids have been identified by the GC-MS technique on the previously derivatised (Phenomenex Faast Kit) extract samples by comparison with the mass spectra and retention-time of the standards...
October 12, 2017: Amino Acids
https://www.readbyqxmd.com/read/28989248/potential-antitumor-effects-of-pomegranates-and-its-ingredients
#9
REVIEW
Arshad H Rahmani, Mohammed A Alsahli, Saleh A Almatroodi
The treatment based on plant or plant derivatives is a promising strategy in the killing of cancers cells. Moreover, wide-ranging finding has established that medicinal plant and its ingredient modulate several cells signaling pathways or inhibiting the carcinogenesis process. In this vista, pomegranates fruits, seeds and peels illustrate cancer preventive role seems to be due to rich source of antioxidant and other valuable ingredients. Furthermore, anti-tumour activities of pomegranates have been evidences through the modulation of cell signaling pathways including transcription factor, apoptosis and angiogenesis...
July 2017: Pharmacognosy Reviews
https://www.readbyqxmd.com/read/28980930/study-of-anticancer-and-antibacterial-activities-of-foeniculum-vulgare-justicia-adhatoda-and-urtica-dioica-as-natural-curatives
#10
R Batool, H Salahuddin, T Mahmood, M Ismail
High-throughput technologies, such as synthetic biology and genomics have paved new paths for discovery and utility of medicinally beneficial plants. Bioactive molecules isolated from different plants have significantly higher biological activities. The present study was done to analyze antibacterial potential of some medicinal plants against multi drug resistant (MDR) pathogens and anticancer effect against MCF-7 cell line. Methanolic and ethanolic extracts were tested for their antibacterial activity by disc diffusion method against six MDR bacterial strains and for cytotoxicity evaluation by MTT assay...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28980927/antioxidant-activities-anticancer-activity-and-polyphenolics-profile-of-leaf-fruit-and-stem-extracts-of-pistacia-lentiscus-from-tunisia
#11
M Yemmen, A Landolsi, J Ben Hamida, F Mégraud, M Trabelsi Ayadi
Plant derived compounds have played an important role in the development of several clinically useful anticancer drugs. The aim of the present study was 1) to evaluate for the first time the anti-proliferative activity of a polyphenol enriched extract obtained from leaf, fruit and stem of Tunisian variety of Pistacia lentiscus against two cultured cancer cells, and 2) to carry out a phytochemical analysis of vegetable extracts particularly by determining the chemical composition of phenolics (total polyphenols, flavonoids and condensed tannins content in solvents with varying polarities), 3) to  evaluate the antioxidant activity and identify the major compounds by RP-HPLC...
September 30, 2017: Cellular and Molecular Biology
https://www.readbyqxmd.com/read/28976773/isolation-and-structural-characterization-of-echinocystic-acid-triterpenoid-saponins-from-the-australian-medicinal-and-food-plant-acacia-ligulata
#12
Diana Jæger, Chi P Ndi, Christoph Crocoll, Bradley S Simpson, Bekzod Khakimov, Ruth Marian Guzman-Genuino, John D Hayball, Xiaohui Xing, Vincent Bulone, Philip Weinstein, Birger L Møller, Susan J Semple
The Australian plant Acacia ligulata has a number of traditional food and medicinal uses by Australian Aboriginal people, although no bioactive compounds have previously been isolated from this species. Bioassay-guided fractionation of an ethanolic extract of the mature pods of A. ligulata led to the isolation of the two new echinocystic acid triterpenoid saponins, ligulatasides A (1) and B (2), which differ in the fine structure of their glycan substituents. Their structures were elucidated on the basis of 1D and 2D NMR, GC-MS, LC-MS/MS, and saccharide linkage analysis...
October 4, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/28975109/phytotherapy-of-nephrotoxicity-induced-by-cancer-drugs-an-updated-review
#13
REVIEW
Saeid Heidari-Soreshjani, Majid Asadi-Samani, Qian Yang, Ali Saeedi-Boroujeni
CONTEXT: Kidney is one of the vital organs maintaining homeostasis of body and thus dysfunction of kidney affects quality of life and health severely. Anticancer drugs, particularly chemotherapeutic agents, cause high toxicity leading kidney dysfunction and irreparable kidney injury. Therefore, attention has recently been paid to seeking out alternatives such as nature-based drugs that are effective but less toxic. In this regard, this systematic review article is to report and introduce the most important medicinal plants and their derivatives that are used to reduce anticancer drug-induced nephrotoxicity...
July 2017: Journal of Nephropathology
https://www.readbyqxmd.com/read/28970154/evaluation-of-extracts-prepared-from-16-plants-used-in-yao-ethnomedicine-as-potential-anticancer-agents
#14
Nadin Marwan Almosnid, Xiaolei Zhou, Lihe Jiang, Amy Ridings, Deborah Knott, Shuo Wang, Fan Wei, Jingquan Yuan, Elliot Altman, Ying Gao, Jianhua Miao
ETHNOPHARMACOLOGICAL RELEVANCE: Medicines of the Yao ethnic group in China are a special branch of traditional Chinese medicine (TCM) and are well documented for use in disease prevention. According to an ethnopharmacological survey, there are 1392 species of medicinal plants that have been documented as Yao ethnomedicines and 104 of these species are used routinely. This study evaluated a partial collection of these 104 core plant species for their potential as anticancer agents. MATERIAL AND METHODS: A literature study of scientific journals and books in the local language was conducted...
September 29, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28964869/anti-proliferative-and-pro-apoptotic-effects-of-uncaria-tomentosa-aqueous-extract-in-squamous-carcinoma-cells
#15
Francesca Ciani, Simona Tafuri, Annaelena Troiano, Alessio Cimmino, Bianca Saveria Fioretto, Andrea Maria Guarino, Alessandra Pollice, Maria Vivo, Antonio Evidente, Domenico Carotenuto, Viola Calabrò
Uncaria tomentosa (Willd.) DC. (Rubiacee), also known as uña de gato, is a plant that grows wild in the upper Amazon region of Peru and has been widely used in folk medicine to treat several health conditions including cancer. We have produced an aqueous extract from Uncaria tomentosa (UT-ex) and analyzed its effects on squamous carcinoma cells and immortalized HaCaT keratinocytes. Squamous cell carcinoma (SCC) is an uncontrolled growth of abnormal cells arising in the skin's squamous layer of epidermis. When detected at an early stage, SCCs are almost curable, however, if left untreated, they can penetrate the underlying tissue and become disfiguring...
September 28, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28964837/chlorophyll-rich-biomolecular-fraction-of-a-cadamba-loaded-into-polymeric-nanosystem-coupled-with-photothermal-therapy-a-synergistic-approach-for-cancer-theranostics
#16
Deepak Pemmaraju, Tejaswini Appidi, Gillipsie Minhas, Surya Prakash Singh, Nooruddin Khan, Mahadeb Pal, Rohit Srivastava, Aravind Kumar Rengan
Development of multifunctional biodegradable nanomaterials to encapsulate hydrophobic drugs and their triggered release in cancer theranostics is a challenge. In the current study, we report the encapsulation of potent anticancer - chlorophyll rich biomolecular fraction from the plant Anthocephalus cadamba into a polymeric nanosystem. The biomolecular fraction was combined with an NIR dye IR-780 to make it photo-thermally active. It was evaluated for its combinatorial (biomolecular extract and photothermal mediated) synergistic cytotoxicity in skin cancer cells...
September 27, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28963600/ros-mediated-cytotoxic-activity-of-zno-and-ceo2-nanoparticles-synthesized-using-the-rubia-cordifolia-l-leaf-extract-on-mg-63-human-osteosarcoma-cell-lines
#17
Natarajan Sisubalan, Vijayan Sri Ramkumar, Arivalagan Pugazhendhi, Chandrasekaran Karthikeyan, Karuppusamy Indira, Kasi Gopinath, Abdulrahman Syedahamed Haja Hameed, Mohamed Hussain Ghouse Basha
In the present scenario, the synthesis and characterization of zinc oxide (ZnO) and cerium oxide (CeO2) nanoparticles (NPs) through biological routes using green reducing agents are quite interesting to explore various biomedical and pharmaceutical applications, particularly for the treatment of cancer. This study was focused on the phytosynthesis of ZnO and CeO2 NPs using the leaf extract of Rubia cordifolia L. The active principles present in the plant extract were liable for rapid reduction of Zn and Ce ions to metallic nanocrystals...
September 29, 2017: Environmental Science and Pollution Research International
https://www.readbyqxmd.com/read/28962889/a-new-clerodane-furano-diterpene-glycoside-from-tinospora-cordifolia-triggers-autophagy-and-apoptosis-in-hct-116-colon-cancer-cells
#18
Neha Sharma, Ashok Kumar, P R Sharma, Arem Qayum, Shashank K Singh, Prabhu Dutt, Satya Paul, Vivek Gupta, M K Verma, N K Satti, R Vishwakarma
ETHNOPHARMACOLOGICAL RELEVANCE: Tinospora cordifolia is a miraculous ayurvedic herb used in the treatment of innumerable diseases such as diabetes, gonorrhea, secondary syphilis, anaemia, rheumatoid arthritis, dermatological diseases, cancer, gout, jaundice, asthma, leprosy, in the treatment of bone fractures, liver & intestinal disorders, purifies the blood, gives new life to the whole body; (rejuvenating herb) and many more. Recent studies have revealed the anticancer potential of this plant but not much work has been done on the anticancer chemical constituents actually responsible for its amazing anticancer effects...
September 27, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28962082/protective-effect-of-schisandra-chinensis-bee-pollen-extract-on-liver-and-kidney-injury-induced-by-cisplatin-in-rats
#19
Haibo Huang, Zhenhuang Shen, Qianqian Geng, Zhenhong Wu, Peiying Shi, Xiaoqing Miao
Cisplatin (CP) has been used to cure numerous forms of cancers effectively in clinics, however, it could induce some toxic effects. Bee pollen is a natural compound, produced by honey bees. It is obtained from collected flower pollen and nectar, mixed with bee saliva. Bee pollen produced from Schisandra chinensis plants is described to exert potent antioxidant effects and to be a free radical scavenger. The purpose of this study was to investigate the effects of therapeutic treatment with Schisandra chinensis bee pollen extract (SCBPE) on liver and kidney injury induced by CP...
September 25, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/28960911/biogenic-synthesis-of-copper-oxide-nanoparticles-using-olea-europaea-leaf-extract-and-evaluation-of-their-toxicity-activities-an-in-vivo-and-in-vitro-study
#20
Ghassan M Sulaiman, Amer T Tawfeeq, Marwa D Jaaffer
Copper oxide nanoparticles (CUNPs) were synthesized using Olea europaea leaf extract as reducing and protecting agent. The formation of nanoparticles was observed through a color change from yellowish to brownish black. The CUNPs were confirmed with UV-Vis spectrophotometer, which revealed a peak absorbance at 289 nm. The synthesized CUNPs were characterized by XRD, FTIR, SEM, and TEM. The XRD pattern revealed that CUNPs were crystalline in nature with a diameter around 20 nm. FTIR spectral analysis showed that CUNPs were capped with plant constituents...
September 28, 2017: Biotechnology Progress
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