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Plant extract and cancer

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https://www.readbyqxmd.com/read/28531979/synthesis-and-characterization-of-glycyrrhizic-acid-coated-iron-oxide-nanoparticles-for-hyperthermia-applications
#1
Mostafa Saeedi, Omid Vahidi, Shahin Bonakdar
In the present study, iron oxide magnetic nanoparticles (IONPs) were synthesized using the oxidative precipitation method for biomedical applications. Glycyrrhizic acid (GA) extracted from the roots of licorice plant was used as the coating agent for the synthesized nanoparticles (GAIONPs). The crystal phase, morphology and size were investigated by XRD, FE-SEM and TEM. The saturation magnetization (ms) value of the nanoparticles was measured by VSM indicating lowered ms of the GAIONPs with respect to that of the IONPs due to the presence of GA...
August 1, 2017: Materials Science & Engineering. C, Materials for Biological Applications
https://www.readbyqxmd.com/read/28530184/green-synthesis-of-silver-nanoparticles-using-mentha-pulegium-and-investigation-of-their-antibacterial-antifungal-and-anticancer-activity
#2
Ali Hamad Abd Kelkawi, Abolghasem Abbasi Kajani, Abdol-Khalegh Bordbar
A simple and eco-friendly method for efficient synthesis of stable colloidal silver nanoparticles (AgNPs) using Mentha pulegium extracts is described. A series of reactions was conducted using different types and concentrations of plant extract as well as metal ions to optimize the reaction conditions. AgNPs were characterized by using UV-vis spectroscopy, transmission electron microscopy, atomic force microscopy, dynamic light scattering, zetasizer, energy-dispersive X-ray spectroscopy (EDAX) and Fourier transform infrared spectroscopy (FTIR)...
June 2017: IET Nanobiotechnology
https://www.readbyqxmd.com/read/28528091/antiproliferative-activity-of-ontario-grown-onions-against-colorectal-adenocarcinoma-cells
#3
Abdulmonem I Murayyan, Cynthya M Manohar, Gordon Hayward, Suresh Neethirajan
Cancer is the leading cause of mortality in Canada and other industrialized nations; the development of new/improved cancer therapies is desperately needed and continues to be a major focus of cancer research. Flavonoids, which are found in high levels in onions, have been shown to exert antiproliferative and potentially anti-cancer activities. To test their therapeutic potential, we assessed the antiproliferative, cytotoxic, apoptosis-inducing, and anti-migratory activities of five onion varieties grown in Ontario against human adenocarcinoma (Caco-2) cells...
June 2017: Food Research International
https://www.readbyqxmd.com/read/28527995/effect-of-aconitum-coreanum-polysaccharide-and-its-sulphated-derivative-on-the-migration-of-human-breast-cancer-mda-mb-435s-cell
#4
Yandong Zhang, Wei Wu, Lihua Kang, Dehai Yu, Chunshui Liu
Polysaccharides extracted from medicinal plants possess multiple functions. However, the inhibitory capacity of polysaccharides on the metastasis of breast cancer remains unclear. In the present study, we investigated the inhibitory activity of Aconitum coreanum polysaccharide (ACP1) and its sulphated derivative ACP1-s on migratory behaviour of human breast cancer cells MDA-MB-435s and evaluated the underlying molecular mechanism. The data from Transwell assay indicated that ACP1 and ACP1-s caused a significant inhibition of MDA-MB-435s cell migration in vitro...
May 17, 2017: International Journal of Biological Macromolecules
https://www.readbyqxmd.com/read/28525602/aloin-a-component-of-the-aloe-vera-plant-leaf-induces-pathological-changes-and-modulates-the-composition-of-microbiota-in-the-large-intestine-of-f344-n-male-rats
#5
Mary D Boudreau, Greg R Olson, Volodymyr P Tryndyak, Matthew S Bryant, Robert P Felton, Frederick A Beland
In a previous study, the oral administration of an Aloe vera whole leaf extract induced dose-related mucosal and goblet cell hyperplasia in the rat colon after 13-weeks and colon cancer after two years. The primary goal of this study was to determine whether or not the administration of aloin, a component of the Aloe vera plant leaf, would replicate the pathophysiological effects that were observed in rats in the previous study with an Aloe vera whole leaf extract. Groups of 10 male F344/N rats were administered aloin at 0, 6...
May 19, 2017: Toxicological Sciences: An Official Journal of the Society of Toxicology
https://www.readbyqxmd.com/read/28524727/e-cadherin-%C3%AE-catenin-complex-a-target-for-anticancer-and-antimetastasis-plants-plant-derived-compounds
#6
Majid Tafrihi, Roohollah Nakhaei Sistani
Plants reputed to have cancer-inhibiting potential and putative active components derived from those plants have emerged as an exciting new field in cancer study. Some of these compounds have cancer-inhibiting potential in different clinical staging levels, especially metastasis. A few of them which stabilize cell-cell adhesions are controversial topics. This review article introduces some effective herbal compounds that target E-cadherin/β-catenin protein complex. In this article, at first, we briefly review the structure and function of E-cadherin and β-catenin proteins, Wnt signaling pathway, and its target genes...
May 19, 2017: Nutrition and Cancer
https://www.readbyqxmd.com/read/28524540/antineoplastic-effects-of-clove-buds-syzygium-aromaticum-l-in-the-model-of-breast-carcinoma
#7
Peter Kubatka, Sona Uramova, Martin Kello, Karol Kajo, Peter Kruzliak, Jan Mojzis, Desanka Vybohova, Marian Adamkov, Karina Jasek, Zora Lasabova, Pavol Zubor, Silvia Fialova, Svetlana Dokupilova, Peter Solar, Martin Pec, Katarina Adamicova, Jan Danko, Mariusz Adamek, Dietrich Busselberg
It is supposed that plant functional foods, rich in phytochemicals, may potentially have preventive effects in carcinogenesis. In this study, the anticancer effects of cloves in the in vivo and in vitro mammary carcinoma model were assessed. Dried flower buds of cloves (CLOs) were used at two concentrations of 0.1% and 1% through diet during 13 weeks after the application of chemocarcinogen. After autopsy, histopathological and immunohistochemical analyses of rat mammary carcinomas were performed. Moreover, in vitro evaluation using MCF-7 cells was carried out...
May 19, 2017: Journal of Cellular and Molecular Medicine
https://www.readbyqxmd.com/read/28521399/acetonitrile-extract-of-salvia-miltiorrhiza-radix-exhibits-growth-inhibitory-effects-on-prostate-cancer-cells-through-the-induction-of-cell-cycle-arrest-and-apoptosis
#8
June Lee, Bu Young Choi, Young-Sam Keum
In the present study, the effects of the acetonitrile or water extracts from 400 selected traditional medicinal plants on the growth of PC-3 cells were investigated, and it was demonstrated that an acetonitrile extract of Salvia miltiorrhiza Radix exhibited the most marked cytotoxic effects on PC-3 cells. It was observed that the acetonitrile extract of S. miltiorrhiza Radix induced marked cell cycle arrest and apoptosis in PC-3 cells through the generation of intracellular reactive oxygen species. It was also demonstrated that oral administration of the acetonitrile extract of S...
May 2017: Oncology Letters
https://www.readbyqxmd.com/read/28514737/integration-of-phytochemicals-and-phytotherapy-into-cancer-precision-medicine
#9
REVIEW
Thomas Efferth, Mohamed E M Saeed, Elhaj Mirghani, Awadh Alim, Zahir Yassin, Elfatih Saeed, Hassan E Khalid, Salah Daak
Concepts of individualized therapy in the 1970s and 1980s attempted to develop predictive in vitro tests for individual drug responsiveness without reaching clinical routine. Precision medicine attempts to device novel individual cancer therapy strategies. Using bioinformatics, relevant knowledge is extracted from huge data amounts. However, tumor heterogeneity challenges chemotherapy due to genetically and phenotypically different cell subpopulations, which may lead to refractory tumors. Natural products always served as vital resources for cancer therapy (e...
April 27, 2017: Oncotarget
https://www.readbyqxmd.com/read/28507944/a-survey-on-phytochemical-composition-and-biological-activity-of-zygophyllum-fabago-from-iran
#10
Saeid Yaripour, Mohammad-Reza Delnavazi, Parina Asgharian, Samira Valiyari, Saeed Tavakoli, Hossein Nazemiyeh
Purpose: Zygophyllum fabago L. (Z. fabago) is a widespread perennial herb which is used as a medicinal plant in traditional medicine of Iran, Turkey and China. The present study was a survey on phytochemical constituents and biological activities of this plant. Methods: Methanolic extract of the roots was fractionated over a C-18 pre-packed cartridge (Sep-pak) and chromatographic separation was performed on a reversed-phase preparative HPLC. Structural elucidation of the isolated compounds was carried out using UV, (1)H-NMR and 13C-NMR spectral analyses...
April 2017: Advanced Pharmaceutical Bulletin
https://www.readbyqxmd.com/read/28506259/detection-of-antibacterial-activities-of-miswak-kalonji-and-aloe-vera-against-oral-pathogens-anti-proliferative-activity-against-cancer-cell-line
#11
Sameen Amjed, Kashaf Junaid, Junaid Jafar, Tuaha Amjad, Waqas Maqsood, Nadia Mukhtar, Kanza Tariq, Musarrat Sharif, Sana Javaid Awan, Farheen Ansari
BACKGROUND: Emerging drug resistance and hindrance of treatment is provoking scientists to search new, less expensive medicinally active compounds. Dental diseases caused by oral pathogens are very frequent chronic infections around the world. The medical potentials of a lot of Pakistani local herbs and herbal combinations is relatively unknown, hence attempted to explore. A study was designed to investigate potential role of local medicinal herbs for example Miswak, Kalonji & Aloe vera as antimicrobial, antioxidant and anti-proliferative agents against oral pathogens and cancer cell line...
May 15, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28501691/biosynthesis-and-characterization-of-copper-oxide-nanoparticles-and-its-anticancer-activity-on-human-colon-cancer-cell-lines-hct-116
#12
V Gnanavel, V Palanichamy, Selvaraj Mohana Roopan
The eco-friendly synthesis of nanoparticles through green route from plant extracts have renowned a wide range of application in the field of modern science, due to increased drug efficacy and less toxicity in the nanosized mediated drug delivery model. In the present study, our research groups have biosynthesized the stable and cost effective copper oxide nanoparticles (CuO NPs) from the leaves of (Ormocarpum cochinchinense) O. cochinchinense. The synthesis of crystalline CuO NPs from the leaf extract of O...
May 2, 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28495603/ethnopharmacological-uses-phytochemistry-biological-activities-and-therapeutic-applications-of-clinacanthus-nutans-burm-f-lindau-a-comprehensive-review
#13
REVIEW
Muhamad Noor Alfarizal Kamarudin, Md Moklesur Rahman Sarker, Habsah Abdul Kadir, Long Chiau Ming
ETHNOPHARMACOLOGICAL RELEVANCE: Clinacanthus nutans (Burm. f.) Lindau, a widely used medicinal plant, is extensively grown in tropical Asia and Southeast Asian countries. C. nutans, with its broad spectrum of pharmacological activities, has been traditionally used to treat cancer, inflammatory disorders, diabetes, insect bites, and skin problems, consumed as a vegetable, mixed with fresh juices, in concoctions, and as a whole plant. The present review analyzes the advances in the ethnopharmacology, phytochemistry, pharmacology, and toxicology of C...
May 8, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28494451/anthocyanins-prevent-colorectal-cancer-development-in-a-mouse-model
#14
Elisabeth Lippert, Petra Ruemmele, Florian Obermeier, Stefan Goelder, Claudia Kunst, Gerhard Rogler, Nadja Dunger, Helmut Messmann, Arndt Hartmann, Esther Endlicher
BACKGROUND: Colorectal cancer is the main leading cause of cancer-related deaths worldwide. Present data suggest that plant-derived anthocyanins have anti-inflammatory and chemopreventive properties. This study was aimed at evaluating the effect of an anthocyanin-rich extract from bilberries on colorectal tumour development and growth in the administration of azoxymethan (AOM)/dextran sodium sulfate (DSS) mouse model. METHODS: Colonic carcinogenesis was induced by AOM and DSS 3 or 5%, respectively, in 50 female Balb/c mice...
May 12, 2017: Digestion
https://www.readbyqxmd.com/read/28492800/fungal-infection-control-by-garlic-extracts-allium-sativum-l-and-modulation-of-peritoneal-macrophages-activity-in-murine-model-of-sporotrichosis
#15
J P Burian, L V S Sacramento, I Z Carlos
Garlic (Allium sativum L.) is grown all over the world as seasoning and medicinal vegetable since 3,000 BC. Allicin is the main component of garlic, being attributed to it the most of its biological activities, such as bactericidal, antifungal and antiviral actions. However, other compounds of garlic present antioxidant, hypocholesterolemic, vasodilator activities, protective action against different types of cancer, and immunomodulatory. Fungal infections are important causes of morbidity and mortality in people mainly in immunosuppressed ones...
May 4, 2017: Brazilian Journal of Biology, Revista Brasleira de Biologia
https://www.readbyqxmd.com/read/28490965/protective-effects-of-fennel-oil-extract-against-sodium-valproate-induced-hepatorenal-damage-in-albino-rats
#16
Wael M Al-Amoudi
Foeniculum vulgare (Apiaceae) is commonly known as fennel. This herb is well-known worldwide and traditionally used as curative herbal therapy for the treatment of epileptic disease, seizurescarminative, digestive, lactogogue, diuretic, treating respiratory and gastrointestinal disorders. The aim of present study is to investigate the possible effect of fennel oil against the toxicity of Sodium-Valproic (SVP) in albino rats. In order to assess the protection of fennel oil on SVP induced hepato- and nephro-toxicity, male albino rats were treated with 1 ml/kg b...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28490952/biological-activity-of-xanthium-strumarium-seed-extracts-on-different-cancer-cell-lines-and-aedes-caspius-culex-pipiens-diptera-culicidae
#17
Fahd A Al-Mekhlafi, Nael Abutaha, Ashraf M A Mashaly, Fahd A Nasr, Khalid E Ibrahim, Mohamed A Wadaan
Effects of methanol extracts of Xanthium strumarium on different cancer cell lines and on the mortality rates of Aedes caspius, Culex pipiens (Diptera: Culicidae) were investigated. Among the cell lines tested, the Jurkat cell line was the most sensitive to the methanol extract and ethyl acetate fraction, with reported LC50 values of 50.18 and 48.73 μg/ml respectively. Conversely, methanol extracts were not that toxic to the A549 cell line though the toxicity increased on further purification. The percentage of growth inhibition was dose dependent for the methanol extract and ethyl acetate fraction...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28490944/phytochemical-evaluation-of-roots-of-plumbago-zeylanica-l-and-assessment-of-its-potential-as-a-nephroprotective-agent
#18
R Rajakrishnan, R Lekshmi, P B Benil, J Thomas, A H AlFarhan, V Rakesh, S Khalaf
Search for medicinal plants to treat kidney disorders is an important topic on phytotherapeutical research. Plumbago zeylanica L. is an important medicinal plant with hepatoprotective, anti-inflammatory, anti-diabetic, anti-cancer and anti-hyperlipidemic activities. In the present study, the protective effect of hydroalcoholic extract of P. zeylanica (HAPZ) in cisplatin induced nephrotoxicity was analyzed in Swiss albino mice. Treatment with higher dose (400 mg/kg) of HAPZ significantly reversed the adverse effect of cisplatin on kidney weight, serum urea and creatinine, indicating their renoprotective effect...
May 2017: Saudi Journal of Biological Sciences
https://www.readbyqxmd.com/read/28489194/antiproliferative-activity-in-tumor-cell-lines-antioxidant-capacity-and-total-phenolic-flavonoid-and-tannin-contents-of-myrciaria-floribunda
#19
Luis A C Tietbohl, Adriana P Oliveira, Ricardo S Esteves, Ricardo D D G Albuquerque, Diogo Folly, Francisco P Machado, Arthur L Corrêa, Marcelo G Santos, Ana L G Ruiz, Leandro Rocha
Myrciaria floribunda (H. West ex Willd.) O. Berg, Myrtaceae, is a native plant species of the Atlantic Rain Forest, from north to south of Brazil. The lyophilized ethyl acetate extract from the leaves of M. floribunda was investigated for its antiproliferative activity in tumor cell lines, antioxidant capacity and its total phenolic, flavonoid and tannin contents. Antiproliferative activity was tested in vitro against seven human cancer cells and against immortalized human skin keratinocytes line (HaCat, no cancer cell)...
May 2, 2017: Anais da Academia Brasileira de Ciências
https://www.readbyqxmd.com/read/28488862/gardenifolins-a-h-scalemic-neolignans-from-gardenia-ternifolia-chiral-resolution-configurational-assignment-and-cytotoxic-activities-against-the-hela-cancer-cell-line
#20
Dieudonné Tshitenge Tshitenge, Doris Feineis, Suresh Awale, Gerhard Bringmann
From the tropical plant Gardenia ternifolia Schumach. and Thonn. (Rubiaceae), eight stereoisomeric 2,3-dihydrobenzo[b]furan neolignans, named gardenifolins A-H (1a-d and 2a-d), were isolated and fully structurally characterized. Reversed-phase chromatography of a stem bark extract afforded two peaks, viz. mixtures I and II, each one consisting of two diastereomers and their respective enantiomers. They were resolved and stereochemically analyzed by HPLC on a chiral phase coupled to electronic circular dichroism (ECD) spectroscopy, giving single ECD spectra of all eight stereoisomers...
May 10, 2017: Journal of Natural Products
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