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Plant extract and cancer

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https://www.readbyqxmd.com/read/28816550/a-review-on-biosynthesis-analytical-techniques-and-pharmacological-activities-of-trigonelline-as-a-plant-alkaloid
#1
Neda Mohamadi, Fariba Sharififar, Mostafa Pournamdari, Mehdi Ansari
Trigonelline (TRG) as a polar hydrophilic alkaloid is extracted from many plant species, for example, Trigonella foenum-graecum, Allium sepapea, Coffea sp, Pissum sativum, Glycine max, and Lycopersicon esculentum. Numerous biological activities have been reported for TRG such as protection of heart and liver and treatment of hyperglycemia, hypercholesterolemia, nervous and hormonal disorders, and cancers. Thus, the aim of this review is to summarize some information about TRG's biosynthesis pathway, pharmacological activity, pharmacokinetics, and analytical techniques to introduce TRG as an alternative choice to treat the various diseases...
August 17, 2017: Journal of Dietary Supplements
https://www.readbyqxmd.com/read/28816367/the-in-vitro-and-in-vivo-antiangiogenic-effects-of-flavokawain-b
#2
Mariana C Rossette, Débora C Moraes, Erika K Sacramento, Marco Aurélio Romano-Silva, Juliana L Carvalho, Dawidson A Gomes, Hanna Caldas, Eitan Friedman, Luciana Bastos-Rodrigues, Luiz De Marco
Angiogenesis is implicated in the development of a variety of pathological processes, most commonly cancer. It is essential for tumor growth and metastasis, making it an important cancer therapeutic target. Naturally occurring substances have led to the discovery of anticancer agents. Flavokawain B (FKB), a chalcone isolated from the root extracts of kava-kava plant, inhibits proliferation and causes apoptosis in vitro and in vivo of various cancer cell lines. The antimetastatic potential of FKB has also been suggested...
August 17, 2017: Phytotherapy Research: PTR
https://www.readbyqxmd.com/read/28811896/effect-of-achillea-wilhelmsii-extract-on-expression-of-the-human-telomerase-reverse-transcriptase-mrna-in-the-pc3-prostate-cancer-cell-line
#3
Mojtaba Ashtiani, Fariba Nabatchian, Hamid Reza Galavi, Ramin Saravani, Farzaneh Farajian-Mashhadi, Saeedeh Salimi
Evidence has indicated that human telomerase reverse transcriptase (hTERT) was overexpressed in prostate cancer (PCa). Achillea wilhelmsii (AW) is a plant that has been traditionally used for its medicinal properties. The aim of current study was to evaluate the effects of AW extract on a PCa cell line. The cytotoxic activity of the hydroalcoholic extract of AW was studied on the PCa PC3 cell line using MTT assay. Flow cytometry was used to evaluate the effects of the extract on the apoptosis. The expression of hTERT mRNA was analyzed by the reverse transcription-quantitative polymerase chain reaction method...
September 2017: Biomedical Reports
https://www.readbyqxmd.com/read/28811220/euphorbia-lunulata-extract-acts-on-multidrug-resistant-gastric-cancer-cells-to-inhibit-cell-proliferation-migration-and-invasion-arrest-cell-cycle-progression-and-induce-apoptosis
#4
Zhaoying Fu, Xiaodong Han, Juan Du, Xiaoxiao Han, Weipeng Liu, Shumei Shao, Xiaobin Liu
ETHNOPHARMACOLOGICAL RELEVANCE: The milky sap or the aboveground part of the plant Euphorbia lunulata has long been used by Chinese people to treat noncancerous growths and cancerous ailments but the specific mode of action and the action mechanism remain to be elucidated. AIM OF THE STUDY: To investigate the effects of Euphorbia lunulata extract on cell proliferation, migration, invasion, cell cycle progression, and apoptosis of multidrug resistant human gastric cancer cells; To study the mechanism of apoptosis induction by Euphorbia lunulata extract in multidrug resistant human gastric cancer cells...
August 12, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/28808404/in-vitro-antioxidant-and-antiproliferative-activities-of-various-solvent-fractions-from-clerodendrum-viscosum-leaves
#5
Anil Khushalrao Shendge, Tapasree Basu, Dipankar Chaudhuri, Sourav Panja, Nripendranath Mandal
BACKGROUND: Free radicals such as reactive oxygen and nitrogen species, generated in the body, play an important role in the fulfillment of various physiological functions but their imbalance in the body lead to cellular injury and various clinical disorders such as cancer, neurodegenaration, and inflammation. OBJECTIVE: The objective of this study is to fight this problem, natural antioxidant from plants can be considered as possible protective agents against various diseases such as cancer which might also modify the redox microenvironment to reduce the genetic instability...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28808383/chemopreventive-potential-of-major-flavonoid-compound-of-methanolic-bark-extract-of-saraca-asoca-roxb-in-benzene-induced-toxicity-of-acute-myeloid-leukemia-mice
#6
Manas Kumar Mukhopadhyay, Mithun Shaw, Debjani Nath
BACKGROUND: Saraca asoca (SA) (Roxb.) is one of the folk medicinal plants found in India, Bangladesh, and Sri Lanka. Its major biological activity appears due to the presence of flavonoid group of compounds in its bark extract. OBJECTIVE: In this study, our research aims to analyze the chemopreventive effect of flavonoids, especially a natural phenol catechin present in the bark methanolic extract of SA on acute myeloid leukemia (AML) mice. MATERIALS AND METHODS: The total bark extract was partitioned and analyzed on thin-layer chromatography (TLC) plate...
July 2017: Pharmacognosy Magazine
https://www.readbyqxmd.com/read/28803233/comprehensive-analysis-of-the-chemical-composition-and-in-vitro-cytotoxic-mechanisms-of-pallines-spinosa-flower-and-leaf-essential-oils-against-breast-cancer-cells
#7
Ayman M Saleh, Mahmoud A Al-Qudah, Amre Nasr, Sayed A Rizvi, Anwar Borai, Mustafa Daghistani
BACKGROUND/AIMS: In our quest for new natural anticancer agents, we studied the cytotoxicity of the essential oils extracted from flowers and leaves of Pallines spinosa. METHODS: The essential oils were extracted by hydrodistillation and solid phase microextraction (SPME) from flowers and leaves of the plant and their composition was determined by GC/GC-MS. The cytotoxicity of the oils was evaluated against MCF-7 and MDA-MB-231 breast adenocarcinomas, and the non-cancerous MCF-10-2A cells, using a flow cytometry-based assay Apoptosis was evaluated by flow cytometry, nuclear staining, caspases activation, and Western blotting techniques, and cell cycle by measuring DNA contents...
August 11, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28800364/expression-optimization-of-a-cell-membrane-penetrating-human-papillomavirus-type-16-therapeutic-vaccine-candidate-in-nicotiana-benthamiana
#8
Romana J R Yanez, Renate Lamprecht, Milaid Granadillo, Brandon Weber, Isis Torrens, Edward P Rybicki, Inga I Hitzeroth
High-risk human papillomaviruses (hr-HPVs) cause cervical cancer, the fourth most common cancer in women worldwide. A HPV-16 candidate therapeutic vaccine, LALF32-51-E7, was developed by fusing a modified E7 protein to a bacterial cell-penetrating peptide (LALF): this elicited both tumour protection and regression in pre-clinical immunization studies. In the current study, we investigated the potential for producing LALF32-51-E7 in a plant expression system by evaluating the effect of subcellular localization and usage of different expression vectors and gene silencing suppressors...
2017: PloS One
https://www.readbyqxmd.com/read/28795371/hepatoprotective-and-cytotoxic-activities-of-anvillea-garcinii-and-isolation-of-four-new-secondary-metabolites
#9
Shagufta Perveen, Areej Mohammad Al-Taweel, Hasan Soliman Yusufoglu, Ghada Ahmed Fawzy, Ahmed Foudah, Maged Saad Abdel-Kader
Anvillea garcinii is a medicinal plant traditionally used for the treatment of dysentery, gastrointestinal troubles, hepatitis, lung disease, colds, digestive problems and pulmonary affections and in liver diseases. Four new sesquiterpene lactones, garcinamines A-D, along with seven known compounds, were isolated from the leaves of A. garcinii. This is the first report of the isolation of amino acid analogues of parthenolide-type sesquiterpene lactones from the family Asteraceae. Total ethanol extract of leaves as well as the chloroform and n-butanol fractions were tested for their hepatoprotective effect using the carbon tetrachloride liver toxicity model...
August 9, 2017: Journal of Natural Medicines
https://www.readbyqxmd.com/read/28790982/isolation-and-characterization-of-terrein-an-antimicrobial-and-antitumor-compound-from-endophytic-fungus-aspergillus-terreus-jas-2-associated-from-achyranthus-aspera-varanasi-india
#10
Jyoti Goutam, Gunjan Sharma, Vinod K Tiwari, Amrita Mishra, Ravindra N Kharwar, Vijayakumar Ramaraj, Biplob Koch
The present study aimed at characterizing biological potentials of endophyte Aspergillus terreus JAS-2 isolated from Achyranthus aspera. Crude extracted from endophytic fungus JAS-2 was purified and chemically characterized by chromatographic and spectroscopic studies respectively. Spectral assignment of NMR (nuclear magnetic resonance) data, (1)H proton and (13)C carbon analysis along with FTIR data elucidated the structure of compound as 4,5-Dihydroxy-3-(1-propenyl)-2-cyclopenten-1-one. After purification and identification a set of experiment was conducted to explore efficacy of compound...
2017: Frontiers in Microbiology
https://www.readbyqxmd.com/read/28774308/polarity-directed-optimization-of-phytochemical-and-in-vitro-biological-potential-of-an-indigenous-folklore-quercus-dilatata-lindl-ex-royle
#11
Madiha Ahmed, Humaira Fatima, Muhammad Qasim, Bilquees Gul, Ihsan-Ul-Haq
BACKGROUND: Plants have served either as a natural templates for the development of new chemicals or a phytomedicine since antiquity. Therefore, the present study was aimed to appraise the polarity directed antioxidant, cytotoxic, protein kinase inhibitory, antileishmanial and glucose modulatory attributes of a Himalayan medicinal plant- Quercus dilatata. METHODS: Total phenolic and flavonoid contents were determined colorimetrically and various polyphenols were identified by RP-HPLC analysis...
August 3, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28772225/an-lc-ms-ms-method-for-quantitation-of-chemopreventive-sphingadienes-in-food-products-and-biological-samples
#12
J H Suh, A M Makarova, J M Gomez, L A Paul, J D Saba
Colorectal cancer (CRC) is a leading cause of cancer mortality. Diet has a significant influence on colon cancer risk. Identifying chemopreventive agents, dietary constituents, practices and/or diet supplements that promote gut health and reduce the incidence of intestinal neoplasias and CRC could significantly impact public health. Sphingadienes (SDs) are dietary sphingolipids found in plant-based food products. SDs are cytotoxic to colon cancer cells and exhibit chemopreventive properties. The aim of the present study was to develop a sensitive and robust ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS) method for quantifying SDs in food products and biological samples...
July 24, 2017: Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences
https://www.readbyqxmd.com/read/28771714/multifunctional-curcumin-mediate-multitherapeutic-effects
#13
Adeeb Shehzad, Munibah Qureshi, Muhammad Nabeel Anwar, Young Sup Lee
Inflammation can promote the development of arthritis, obesity, cardiovascular, type II diabetes, pancreatitis, metabolic and neurodegenerative diseases, and certain types of cancer. Compounds isolated from plants have been practiced since ancient times for curing various ailments including inflammatory disorders and to support normal physiological functions. Curcumin (diferuloylmethane) is a yellow coloring agent, extracted from turmeric that has been used for the prevention and treatment of various inflammatory diseases...
August 3, 2017: Journal of Food Science
https://www.readbyqxmd.com/read/28769987/anticancer-effects-of-sinocrassulosides-vi-vii-from-silene-viscidula-on-hela-cells
#14
Hang Chen, Qian Ma, Wei Xu, Wan-Ming Li, De-Zheng Yuan, Jia-Mei Wu, Yu-Shan Li, Jin Fang
Natural products are becoming increasingly important in chemoprevention and for cancer therapy. Silene viscidula (S. viscidula), a traditional Chinese herb, has long been used as an anti-inflammatory and neuroleptic agent. However, the anticancer activity of S. viscidula has remained unclear. In this study, 16 compounds were extracted from S. viscidula. Among those compounds, sinocrassulosides VI/VII, an inseparable isomer mixture, possess the strongest inhibitory activity on HeLa cells with the IC50 value of 2...
2017: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/28768532/estrogen-like-and-tissue-selective-effects-of-7-methoxycoumarin-from-ficus-umbellata-moraceae-an-in-vitro-and-in-vivo-study
#15
Stéphane Zingue, Thomas Michel, Chantal Beatrice Magne Nde, Amstrong Nang Njuh, Julia Cisilotto, Derek Tantoh Ndinteh, Colin Clyne, Xavier Fernandez, Tânia Beatriz Creczynski-Pasa, Dieudonné Njamen
BACKGROUND: Ficus umbellata is a medicinal plant previously shown to endow estrogenic properties. Its major component was isolated and characterized as 7-methoxycoumarin (MC). Noteworthy, coumarins and the respective active metabolite 7-hydroxycoumarin analogs have shown aromatase inhibitory activity, which is of particular interest in the treatment of estrogen-dependent cancers. The present work aimed at evaluating the estrogenic/antiestrogenic effects of MC in vitro and in vivo. METHODS: To do so, in vitro assays using E-screen and reporter gene were done...
August 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28768515/a-comparative-assessment-of-antiproliferative-properties-of-resveratrol-and-ethanol-leaf-extract-of-anogeissus-leiocarpus-dc-guill-and-perr-against-hepg2-hepatocarcinoma-cells
#16
Jeremiah Olorunjuwon Olugbami, Robert Damoiseaux, Bryan France, Esther Modupe Onibiyo, Michael Adedapo Gbadegesin, Shivani Sharma, James Kazimierz Gimzewski, Oyeronke Adunni Odunola
BACKGROUND: Epidemiological and experimental evidences have shown cancer as a leading cause of death worldwide. Although the folklore use of plants as a reliable source of health-restoring principles is well-documented, the search for more of such plants that are active against diseases, such as cancer, continues. We report here a laboratory-based evidence of the relevance of an ethanol leaf extract of Anogeissus leiocarpus (A2L) in comparison with resveratrol, a natural polyphenol, in cancer therapy...
August 2, 2017: BMC Complementary and Alternative Medicine
https://www.readbyqxmd.com/read/28764775/an-assessment-on-the-role-of-endophytic-microbes-in-the-therapeutic-potential-of-fagonia-indica
#17
Lubna Rahman, Zabta K Shinwari, Irum Iqrar, Lutfur Rahman, Faouzia Tanveer
BACKGROUND: Natural products of animals, plants and microbes are potential source of important chemical compounds, with diverse applications including therapeutics. Endophytic bacteria that are especially associated with medicinal plants presents a reservoir of therapeutic compounds. Fagonia indica has been recently investigated by numerous researchers because of its striking therapeutic potential especially in cancer. It is also reported that endophytes play a vital role in the biosynthesis of various metabolites; therefore we believe that endophytes associated with F...
August 1, 2017: Annals of Clinical Microbiology and Antimicrobials
https://www.readbyqxmd.com/read/28764290/wheatgrass-green-blood-can-help-to-fight-cancer
#18
Rucha Diwakar Gore, Sangeeta Jayant Palaskar, Anirudha Ratnadeep Bartake
INTRODUCTION: Oral squamous cell carcinoma is the sixth most common cancer worldwide and is one of the leading causes of death especially in developing countries like India. It is usually managed with the help of chemotherapeutic agents that are toxic not only to the tumor cells but also to normal cells in many ways. Whereas the traditional herbal medicines which are used from ancient days in India are generally known to be free of toxic effects and are effective. Wheatgrass is the young grass of the wheat plant 'Tritcumaestivum Linn', family Poaceae (Gramineae)...
June 2017: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/28749106/bioassay-guided-isolation-and-evaluation-of-antiproliferative-effects-of-z-ethylidene-4-6-dimethoxycoumaran-3-one-from-pogostemon-quadrifolius-benth
#19
Sanith Cheriyamundath, Rahul Raghavan, Asoke Banerji, Karel D Klika, Cornelia Ulrich, Robert W Owen, Joseph Madassery
The aim of the study was to isolate and identify the major cytotoxic principle from plant leaves of Pogostemon quadrifolius (Benth.) and evaluate its antiproliferative potential against human cancer cells. Plant leaves were extracted sequentially with a soxhlet apparatus, using petroleum ether, chloroform and methanol solvents. Petroleum ether and chloroform extracts exhibited antiproliferative properties against Caco-2, HeLa, THP-1, MCF-7 and Jurkat E6-1cancer cell lines tested, but methanol extracts failed to exhibit such activity...
July 27, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28741853/application-of-nir-spectroscopy-coupled-with-pls-regression-for-quantification-of-total-polyphenol-contents-from-the-fruit-and-aerial-parts-of-citrullus-colocynthis
#20
Tania S Rizvi, Fazal Mabood, Liaqat Ali, Mohammed Al-Broumi, Hamida K M Al Rabani, Javid Hussain, Farah Jabeen, Suryyia Manzoor, Ahmed Al-Harrasi
INTRODUCTION: Citrullus colocynthis (L.) Schrad is extensively used to treat diabetes, obesity, fever, cancer, amenorrhea, jaundice, leukemia, rheumatism, and respiratory diseases. Chemical studies have indicated the presence of several cucurbitacins, flavones, and other polyphenols in this plant. These phytochemical constituents are responsible for the interesting antioxidant and other biological activities of C. colocynthis. OBJECTIVE: In the present study, for the first time, near infrared (NIR) spectroscopy coupled with partial least square (PLS) regression analysis was used to quantify the polyphenolic phytochemicals of C...
July 25, 2017: Phytochemical Analysis: PCA
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