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Plant extract and cancer

Yang Jianhong, Yan Wei, Yu Yamei, Wang Yuxi, Yang Tao, Xue Linlin, Yuan Xue, Long Caofeng, Liu Zuowei, Chen Xiaoxin, Hu Mengshi, Zheng Li, Qiu Qiang, Pei Heying, Li Dan, Wang Fang, Bai Peng, Wen Jiaolin, Ye Haoyu, Chen Lijuan
Inhibitors that bind to the paclitaxel- or vinblastine-binding sites of tubulin have been part of the pharmacopoeia of anticancer therapy for decades. However, tubulin inhibitors that bind to the colchicine-binding site are not used in clinical cancer therapy, because of their low therapeutic index. To address multidrug resistance to many conventional tubulin-binding agents, numerous efforts have attempted to clinically develop inhibitors that bind the colchicine-binding site. Previously, we have found that millepachine (MIL), a natural chalcone-type small molecule extracted from the plant Millettia pachycarpa, and its two derivatives (MDs) SKLB028 and SKLB050 have potential antitumor activities both in vitro and in vivo...
April 24, 2018: Journal of Biological Chemistry
Syahirah Ahmad Sayuti Nurul, Hamzah Hazilawati, Rosly Shaari Mohd, Farhan Hanif Reduan Mohd, Mohamed Mustapha Noordin, Md Esa Norhaizan
The term Butterfly tea refers to decoction of Mariposa christia vespertilionis leaves which is widely consumed by cancer patients throughout Malaysia and has gained a huge popularity among Malaysians, not only cancer patients but also researchers to discover the real potential of this plant. Herein, the study is aimed at evaluating the possible toxicity in 28-day subacute oral toxicity of ethanolic extract M. christia vespertilionis in male Sprague Dawley rats. The 28-day subacute toxicity study was conducted to detect the no-observed adverse effect level (NOAEL)...
April 2018: Toxicological Research
Masashi Yukawa, Tomoaki Yamauchi, Naoaki Kurisawa, Shakil Ahmed, Ken-Ichi Kimura, Takashi Toda
Many human cancer cells contain more than two centrosomes, yet these cancer cells can form pseudo-bipolar spindles through the mechanism, called centrosome clustering, and survive, instead of committing lethal multipolar mitoses. Kinesin-14/HSET, a minus end-directed motor, plays a crucial role in centrosome clustering. Accordingly, HSET is deemed to be a promising chemotherapeutic target to selectively kill cancer cells. Recently, three HSET inhibitors (AZ82, CW069 and SR31527) have been reported, but their specificity and efficacy have not been evaluated rigorously...
April 20, 2018: Fungal Genetics and Biology: FG & B
Estefanny Ruiz García, Eliana Alviárez Gutierrez, Fabiana Cristina Silveira Alves de Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process. Studies were selected from PubMed and Scopus databases according to the PRISMA statement. The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model. The bias analysis of the 34 selected works was done using the ARRIVE guidelines...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
Afshan Siddiq, Ishrat Younus
Inclusion of vegetables in the diet not only provides dietary fiber, vitamins, minerals, trace elements but also significantly reduces the risk of several diseases. Raphanus sativus L. Var. caudatus belongs to the family Brassicaceae are pods of Radish, and are commonly known as Mungra or Sungra in Pakistan and India. The English name for this species is Rat-tailed radish. This variety of radish is unique, less familiar to the population, and not commonly used as a food source. Furthermore there have been very few studies that report on the potential antioxidant and anti-cancer capabilities of this radish...
April 18, 2018: Metabolic Brain Disease
Xiao Yu, Hongyan Lin, Yu Wang, Wenwen Lv, Shuo Zhang, Ying Qian, Xiaobei Deng, Nannan Feng, Herbert Yu, Biyun Qian
Purpose: d-limonene is a plant extract with widespread application, and it has been recently reported to have antiproliferative and proapoptotic effects on cancer cells. However, the mechanisms by which d-limonene achieves these effects, especially in lung cancer, are not entirely clear. Therefore, the goal of this study was to examine the effects of d-limonene on lung cancer and explore its mechanisms of action. Methods: We examined the therapeutic effects of d-limonene on lung cancer cells and in a xenograft animal model by characterizing its effects on the pathways of apoptosis and autophagy...
2018: OncoTargets and Therapy
Claudia Lara-Espinoza, Elizabeth Carvajal-Millán, René Balandrán-Quintana, Yolanda López-Franco, Agustín Rascón-Chu
Pectins are plant cell wall natural heteropolysaccharides composed mainly of α-1-4 d-galacturonic acid units, which may or may not be methyl esterified, possesses neutral sugars branching that harbor functional moieties. Physicochemical features as pH, temperature, ions concentration, and cosolute presence, affect directly the extraction yield and gelling capacity of pectins. The chemical and structural features of this polysaccharide enables its interaction with a wide range of molecules, a property that scientists profit from to form new composite matrices for target/controlled delivery of therapeutic molecules, genes or cells...
April 18, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Verena Lewenhofer, Lisa Schweighofer, Tobias Ledermüller, Julia Eichsteininger, Hanspeter Kählig, Martin Zehl, Chi H Nguyen, Georg Krupitza, Ali Özmen, Liselotte Krenn
A detannified methanolic extract of Scrophularia lucida L. attenuated the formation of cancer cell-induced circular chemorepellent induced defects (CCIDs) in the lymph endothelial cell barrier, which resemble entry ports for the intravasating tumor into the vasculature as a prerequisite for lymph node metastasis. Therefore, the composition of this extract was studied in an activity-guided approach. Since no data on the secondary metabolites of this plant were available, first phytochemical data were collected in the course of the fractionation of the extract...
2018: Frontiers in Pharmacology
Wenyan Xie, Matthias F Melzig
Herbal medicine is now globally accepted as a valid alternative system of pharmaceutical therapies. Various studies around the world have been initiated to develop scientific evidence-based herbal therapies. Recently, the therapeutic potential of medicinal plant derived miRNAs has attracted great attraction. MicroRNAs have been indicated as new bioactive ingredients in medicinal plants. However, the stability of miRNAs during the herbal preparation process and their bioavailability in humans remain unclear...
April 16, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Jan Tauchen, Lukas Huml, Ludvik Bortl, Ivo Doskocil, Veronika Jarosova, Petr Marsik, Adela Frankova, Zoyla Mirella Clavo Peralta, Maria-Elena Chuspe Zans, Jaroslav Havlik, Oldrich Lapcik, Ladislav Kokoska
Plants mentioned in this study have numerous records in traditional Peruvian medicine being used in treatment of cancer and other diseases likely to be associated with oxidative stress. Amongst the eight plant species tested, only Dysphania ambrosioides exhibited combinatory antioxidant and anti-proliferative effect on a broad spectrum of cancer cells (DPPH and ORAC values = 80.6 and 687.3 μg TE/mg extract, respectively; IC50 against Caco-2, HT-29 and Hep-G2 = 129.2, 69.9 and 130.6, respectively). Alkaloids and phenolic compounds might significantly contribute to anticancer/antioxidant activity of this plant...
April 16, 2018: Natural Product Research
Golnaz Vaseghi, Mohsen Sharifi, Nasim Dana, Ahmad Ghasemi, Afsaneh Yegdaneh
Background: Marine organisms produce a variety of compounds with pharmacological activities including anticancer effects. This study attempt to find cytotoxicity of hexane (HEX), dichloromethane (DCM), and butanol (BUTOH) partitions of Sargassum angustifolium . Materials and Methods: S. angustifolium was collected from Bushehr, a Southwest coastline of Persian Gulf. The plant was extracted by maceration with methanol-ethyl acetate. The extract was evaporated under vacuum and partitioned by Kupchan method to yield HEX, DCM, and BUTOH partitions...
2018: Advanced Biomedical Research
Fabiola Domínguez, Paola Maycotte, Adilene Acosta-Casique, Sofía Rodríguez-Rodríguez, Diego A Moreno, Federico Ferreres, Juan Carlos Flores-Alonso, María Guadalupe Delgado-López, Martín Pérez-Santos, Maricruz Anaya-Ruiz
Plants from the Bursera genus are widely distributed in the tropical dry forests of Mexico. In traditional medicine, extracts from different species of Bursera have been used for a wide range of biological activities, including the treatment of cancer-related symptoms. Compounds present in the Bursera genus include lignans, flavonoids, steroids, short-chain aliphatic alkanes, acetates, alcohols, ketones, and terpenoids. In some instances, secondary metabolites of these classes of compounds may induce cytotoxicity, and therefore we sought to investigate the effects of B...
April 1, 2018: Integrative Cancer Therapies
Ibrahim Babangida Abubakar, Su-Wen Lim, Hwei-San Loh
Recent studies suggested that combined treatment approaches can be used to improve anticancer potency and circumvent the limitations of high-dose tocotrienols administration. Acalypha wilkesiana is a medicinal plant that has been used as an adjunct treatment for cancers in traditional medicine. Herein, the effects of single and combined treatments of β-, γ- and δ-tocotrienols and ethyl acetate extract (9EA) of Acalypha wilkesiana on lung (A549) and brain (U87MG) cancer cells were investigated. γ- and δ-tocotrienols exhibited higher potent antiproliferative effects against A549 (12...
March 2018: Tropical Life Sciences Research
Piyawan Kumnerdkhonkaen, Somprasong Saenglee, Md Ali Asgar, Gulsiri Senawong, Kanoknan Khongsukwiwat, Thanaset Senawong
BACKGROUND: Houttuynia cordata Thunb. and Phyllanthus emblica Linn. are native plants with medicinal and nutritive significance in Asia. The present study was aimed at evaluating antiproliferative effects on human cancer cell lines and identifying the phenolic acid composition of water and ethanolic extracts of the powdered formula of H. cordata fermented broth and P. emblica fruit. METHODS: Anticancer activity of the extracts was evaluated against HeLa, HT29, HCT116, MCF7 and Jurkat cells using an MTT assay and flow cytometric analysis of apoptosis induction and cell cycle arrest...
April 11, 2018: BMC Complementary and Alternative Medicine
Huawei Zhang, Ziping Zhao, Jianwei Chen, Xuelian Bai, Hong Wang
Bioassay-guided fractionation of the crude extract of fermentation broth of one symbiotic strain Aspergillus sp. D from the coastal plant Edgeworthia chrysantha Lindl. led to isolation of one new meroterpenoid, tricycloalternarene 14b ( 1 ), together with four known analogs ( 2 - 5 ), tricycloalternarenes 2b ( 2 ), 3a ( 3 ), 3b ( 4 ), and ACTG-toxin F ( 5 ). Their chemical structures were unambiguously established on the basis of NMR, mass spectrometry, and optical rotation data analysis, as well as by comparison with literature data...
April 9, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Mathew Y Kyei, George O Klufio, Ali Ayamba, Sherif Mohammed
Objective: This study was aimed at identifying Ghanaian traditional medicines used for the management of prostate diseases and their constituents. Reviews of studies conducted on them are also presented. Methodology: This was a prospective study. Traditional Medicine samples from consecutive patients with either lower urinary symptoms (LUTS) presenting at the Urology Unit of the Korle Bu Teaching Hospital (KBTH) in Accra from January 2015 to June 2016 and had a prior treatment with traditional medicines, had the samples retrieved...
September 2017: Ghana Medical Journal
Sathish Sundar Dhilip Kumar, Nicolette Nadene Houreld, Heidi Abrahamse
Curcumin, a low molecular weight, lipophilic, major yellow natural polyphenolic, and the most well-known plant-derived compound, is extracted from the rhizomes of the turmeric ( Curcuma longa ) plant. Curcumin has been demonstrated as an effective therapeutic agent in traditional medicine for the treatment and prevention of different diseases. It has also shown a wide range of biological and pharmacological effects in drug delivery, and has actively been used for the treatment of aging-associated diseases, including cardiovascular diseases, atherosclerosis, neurodegenerative diseases, cancer, rheumatoid arthritis, ocular diseases, osteoporosis, diabetes, hypertension, chronic kidney diseases, chronic inflammation and infection...
April 5, 2018: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
Ge Yu, Na Li, Yan Zhao, Wei Wang, Xiao-Ling Feng
Salidroside is one of the most potent compounds extracted from the plant Rhodiola rosea , and its cardiovascular protective effects have been studied extensively. However, the role of salidroside in human ovarian carcinoma remains unknown. The aim of the current study was to investigate the effects of salidroside on the proliferation and apoptosis of SKOV3 and A2780 cells using MTT assay and acridine orange/ethidium bromide staining. Salidroside activated caspase-3 and upregulated the levels of apoptosis-inducing factor, Bcl-2-associated X and Bcl-2-associated death promoter (Bad) proteins...
May 2018: Oncology Letters
Ochuko L Erukainure, Nadia Ashraf, Asma S Naqvi, Moses Z Zaruwa, Aliyu Muhammad, Adenike D Odusote, Gloria N Elemo
Glioblastoma multiforme (GBM) is a malignant primary type of brain cancer with high proliferation and metastasis rates due to involvement of the microglial cell. It is resistant against available chemotherapy. Many strategic protocols have been developed but prognosis and patient life has not improved substantially. In this study, the anti-metastatic and antioxidant effect of fatty acids from Clerodendrum volubile leaves were investigated in U87-MG (Human Glioblastoma Multiforme) cell lines. The extracted fatty acids were incubated with U87-MG cells for 48 h...
2018: Frontiers in Pharmacology
Akash Ahuja, Young-Su Yi, Mi-Yeon Kim, Jae Youl Cho
ETHNOPHARMACOLOGICAL RELEVANCE: Artemisia asiatica Nakai (Compositae) has a long history as a traditional remedy. Preparation from various parts of the plant (aerial parts and leaves) are used to treat a wide range of diseases including gastric trouble, liver dysfunction, and skin inflammation. AIMS OF THIS REVIEW: The aims of this review were: 1) to provide an overview of recent studies and progress on A. asiatica-derived ethnopharmacological compounds and their pharmacological activities; and 2) to summarize existing evidence and provide insight for future studies...
March 28, 2018: Journal of Ethnopharmacology
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