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https://www.readbyqxmd.com/read/29684859/isorhamnetin-a-hepatoprotective-flavonoid-inhibits-apoptosis-and-autophagy-via-p38-ppar-%C3%AE-pathway-in-mice
#1
Xiya Lu, Tong Liu, Kan Chen, Yujing Xia, Weiqi Dai, Shizan Xu, Ling Xu, Fan Wang, Liwei Wu, Jingjing Li, Sainan Li, Wenwen Wang, Qiang Yu, Jiao Feng, Xiaoming Fan, Yingqun Zhou, Peiqin Niu, Chuanyong Guo
Isorhamnetin, a flavonoid compound extracted from plants' fruit or leaves, like sea buckthorn (Hippophae rhamnoides L.), has many biological functions, including anti-tumor, anti-oxidant and anti-inflammatory effect. The present study is in order to explore the hepatoprotective effect of isorhamnetin on concanavalin A (ConA)-induced acute fulminant hepatitis and the underlying mechanism. Mice were injected with ConA (25 mg/kg) to induce acute fulminant hepatitis, three doses of isorhamnetin (10/30/90 mg/kg) was intraperitoneally administrated about 1 h previously...
April 20, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29684778/improvement-in-productivity-nutritional-quality-and-antioxidative-defense-mechanisms-of-sunflower-helianthus-annuus-l-and-maize-zea-mays-l-in-nickel-contaminated-soil-amended-with-different-biochar-and-zeolite-ratios
#2
Ali Khan Shahbaz, Karolina Lewińska, Javed Iqbal, Qasim Ali, Mahmood-Ur-Rahman, Muhammad Iqbal, Farhat Abbas, Hafiz Muhammad Tauqeer, Pia Muhammad Adnan Ramzani
Nickel (Ni) contaminated soils pose a potential ecological risk to the environment, soil health, and quality of food produced on them. We hypothesized that application of miscanthus biochar (BC) and cationic zeolite (ZE) at various proportions into a Ni contaminated soil can efficiently immobilize Ni and reduce its bioavailability to sunflower (Helianthus annuus L.) and maize (Zea mays L.). An electroplating effluent contaminated soil was amended with BC and ZE, as sole treatments (2% w/w) and their combinations of various ratios (BC, ZE, BC25%ZE75%, BC50%ZE50% and BC75%ZE25%) for immobilization of Ni in the soil...
April 20, 2018: Journal of Environmental Management
https://www.readbyqxmd.com/read/29684553/fission-yeast-cells-overproducing-hset-kifc1-provides-a-useful-tool-for-identification-and-evaluation-of-human-kinesin-14-inhibitors
#3
Masashi Yukawa, Tomoaki Yamauchi, Naoaki Kurisawa, Shakil Ahmed, Ken-Ichi Kimura, Takashi Toda
Many human cancer cells contain more than two centrosomes, yet these cancer cells can form pseudo-bipolar spindles through the mechanism, called centrosome clustering, and survive, instead of committing lethal multipolar mitoses. Kinesin-14/HSET, a minus end-directed motor, plays a crucial role in centrosome clustering. Accordingly, HSET is deemed to be a promising chemotherapeutic target to selectively kill cancer cells. Recently, three HSET inhibitors (AZ82, CW069 and SR31527) have been reported, but their specificity and efficacy have not been evaluated rigorously...
April 20, 2018: Fungal Genetics and Biology: FG & B
https://www.readbyqxmd.com/read/29683473/toxicity-of-the-spiny-thick-foot-pachypodium
#4
Anurag A Agrawal, Aliya Ali, M Daisy Johnson, Amy P Hastings, Dylan Burge, Marjorie G Weber
PREMISE OF THE STUDY: Pachypodium (Apocynaceae) is a genus of iconic stem-succulent and poisonous plants endemic to Madagascar and southern Africa. We tested hypotheses about the mode of action and macroevolution of toxicity in this group. We further hypothesized that while monarch butterflies are highly resistant to cardenolide toxins (a type of cardiac glycoside) from American Asclepias, they may be negatively affected by Pachypodium defenses, which evolved independently. METHODS: We grew 16 of 21 known Pachypodium spp...
April 23, 2018: American Journal of Botany
https://www.readbyqxmd.com/read/29681978/flavonoids-effects-on-hepatocellular-carcinoma-in-murine-models-a-systematic-review
#5
REVIEW
Estefanny Ruiz García, Eliana Alviárez Gutierrez, Fabiana Cristina Silveira Alves de Melo, Rômulo Dias Novaes, Reggiani Vilela Gonçalves
The hepatocellular carcinoma (HCC) is the second most common cause of cancer deaths worldwide. It occurs primarily as manifestation of other pathological processes, such as viral hepatitis, cirrhosis, and toxin exposure that affect directly the cellular process. Studies were selected from PubMed and Scopus databases according to the PRISMA statement. The research filters were constructed using three parameters: flavonoids, hepatocellular carcinoma, and animal model. The bias analysis of the 34 selected works was done using the ARRIVE guidelines...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681972/-in-vitro-bioactivity-of-methanolic-extracts-from-amphipterygium-adstringens-schltdl-schiede-ex-standl-chenopodium-ambrosioides-l-cirsium-mexicanum-dc-eryngium-carlinae-f-delaroche-and-pithecellobium-dulce-roxb-benth-used-in-traditional-medicine-in-mexico
#6
Peter Knauth, Gustavo J Acevedo-Hernández, M Eduardo Cano, Melesio Gutiérrez-Lomelí, Zaira López
Seven out of eight methanolic extracts from five plants native to Mexico were inactive against ten bacterial strains of clinical interest. The fruit extract of Chenopodium ambrosioides inhibited the bacteria Enterococcus faecalis (MIC = 4375  μ g/ml), Escherichia coli (MIC = 1094  μ g/ml), and Salmonella typhimurium (MIC = 137  μ g/ml). The fruit extract of C. ambrosioides was with CC50 = 45  μ g/ml most cytotoxic against the cell-line Caco-2, followed by the leaf extract from Pithecellobium dulce (CC50 = 126  μ g/ml); interestingly, leaves of C...
2018: Evidence-based Complementary and Alternative Medicine: ECAM
https://www.readbyqxmd.com/read/29681909/evaluation-of-seaweed-extracts-from-laminaria-and-ascophyllum-nodosum-spp-as-biostimulants-in-zea-mays-l-using-a-combination-of-chemical-biochemical-and-morphological-approaches
#7
Andrea Ertani, Ornella Francioso, Anna Tinti, Michela Schiavon, Diego Pizzeghello, Serenella Nardi
Seaweed extracts can be employed as biostimulants during crop cultivation owing to their positive effects on plant performance. Therefore, in this study one extract from Laminaria (A) and five extracts from Ascophyllum nodosum (B-F) were assayed on maize ( Zea mays L.) plants supplied for 2 days with 0.5 mL L-1 of single products to evaluate their capacity to stimulate root growth and morphology, nutrition, and sugars accumulation. Firstly, extracts were chemically characterized via Fourier transform infrared (FT-IR) and FT-Raman spectroscopies, and their content in carbon, nitrogen, phenolic acids and hormones (indole-3-acetic acid, IAA, and Isopentenyladenosine, IPA) was quantified...
2018: Frontiers in Plant Science
https://www.readbyqxmd.com/read/29681854/evidence-supports-tradition-the-in-vitro-effects-of-roman-chamomile-on-smooth-muscles
#8
Zsolt Sándor, Javad Mottaghipisheh, Katalin Veres, Judit Hohmann, Tímea Bencsik, Attila Horváth, Dezső Kelemen, Róbert Papp, Loránd Barthó, Dezső Csupor
The dried flowers of Chamaemelum nobile (L.) All. have been used in traditional medicine for different conditions related to the spasm of the gastrointestinal system. However, there have been no experimental studies to support the smooth muscle relaxant effect of this plant. The aim of our research was to assess the effects of the hydroethanolic extract of Roman chamomile, its fractions, four of its flavonoids (apigenin, luteolin, hispidulin, and eupafolin), and its essential oil on smooth muscles. The phytochemical compositions of the extract and its fractions were characterized and quantified by HPLC-DAD, the essential oil was characterized by GC and GC-MS...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29681284/alkylsilyl-speciation-and-direct-sample-preparation-of-plant-cannabinoids-prior-to-their-analysis-by-gc-ms
#9
Blanka Fodor, Imre Boldizsár, Ibolya Molnár-Perl
A literature criticism is given on methods currently using gas chromatography mass spectrometry (GC-MS) to determine plant cannabinoids (p-CBDs). In this study, trialkylsilylation of seven p-CBDs (including their transformation products formed in the drug user's body) was compared applying various alkylsilyl reagents1 and the mass fragmentation properties of the corresponding derivatives were characterized. Derivatization, mass fragmentation and quantitation related model investigations were optimized as a function of the reaction times and conditions...
August 27, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29681192/in-vitro-assessment-of-cytotoxic-genotoxic-and-mutagenic-effects-of-antimalarial-drugs-artemisinin-and-artemether-in-human-lymphocytes
#10
Plínio Cerqueira Dos Santos Cardoso, Carlos Alberto Machado da Rocha, Tatiane Cristina Mota, Marcelo de Oliveira Bahia, Regianne Maciel Dos Santos Correa, Lorena Monteiro Gomes, Diego Di Felipe Avila Alcântara, Taíssa Maíra Thomaz Araújo, Leopoldo Silva de Moraes, Rommel Burbano
Artemisinin is a substance extracted from the Chinese plant Artemisia annua L. widely used in natural medicine for the treatment of various diseases. Artemether is a substance synthesized from artemisinin, and both drugs are commonly administered in the treatment of malaria. Although considered effective antimalarial drugs, very little is known about the genotoxic, cytotoxic and mutagenic effects of these drugs. Therefore, in the present study, we evaluated the genotoxic, mutagenic and cytotoxic effects of artemisinin (12...
April 22, 2018: Drug and Chemical Toxicology
https://www.readbyqxmd.com/read/29680944/effect-of-terbinafine-on-the-biosynthetic-pathway-of-isoprenoid-compounds-in-carrot-suspension-cultured-cells
#11
Begoña Miras-Moreno, Lorena Almagro, María Angeles Pedreño, Ana Belén Sabater-Jara
Terbinafine induced a significant increase of squalene production. Terbinafine increased the expression levels of squalene synthase. Cyclodextrins did not work as elicitors due to the gene expression levels obtained. Plant sterols are essential components of membrane lipids, which contributing to their fluidity and permeability. Besides their cholesterol-lowering properties, they also have anti-inflammatory, antidiabetic and anticancer activities. Squalene, which is phytosterol precursor, is widely used in medicine, foods and cosmetics due to its anti-tumor, antioxidant and anti-aging activities...
April 21, 2018: Plant Cell Reports
https://www.readbyqxmd.com/read/29680740/moringa-concanensis-nimmo-ameliorates-hyperglycemia-in-3t3-l1-adipocytes-by-upregulating-ppar-%C3%AE-c-ebp-%C3%AE-via-akt-signaling-pathway-and-stz-induced-diabetic-rats
#12
Brindha Banu Balakrishnan, Kalaivani Krishnasamy, Ki Choon Choi
Moringa concanensis Nimmo is a medicinal plant for treating various human illnesses including menstrual pain, high blood pressure, jaundice, inflammation, pain, fever, sore eyes, and cholesterol in Indian folk medicine. Despite its versatility, its antihyperglycemic mechanism of action (in vitro and in vivo) remains unclear. Therefore, in this study we developed the possible antihyperglycemic mechanism of action in 3T3-L1 cells by evaluating mRNA and protein expression, which are associated with adipogenesis and lipogenesis (insulin sensitizer)...
April 19, 2018: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29680568/novel-methodology-to-isolate-microplastics-from-vegetal-rich-samples
#13
Alicia Herrera, Paloma Garrido-Amador, Ico Martínez, María Dolores Samper, Juan López-Martínez, May Gómez, Theodore T Packard
Microplastics are small plastic particles, globally distributed throughout the oceans. To properly study them, all the methodologies for their sampling, extraction, and measurement should be standardized. For heterogeneous samples containing sediments, animal tissues and zooplankton, several procedures have been described. However, definitive methodologies for samples, rich in algae and plant material, have not yet been developed. The aim of this study was to find the best extraction protocol for vegetal-rich samples by comparing the efficacies of five previously described digestion methods, and a novel density separation method...
April 2018: Marine Pollution Bulletin
https://www.readbyqxmd.com/read/29680497/rapid-and-visual-detection-of-the-main-chemical-compositions-in-maize-seeds-based-on-raman-hyperspectral-imaging
#14
Guiyan Yang, Qingyan Wang, Chen Liu, Xiaobin Wang, Shuxiang Fan, Wenqian Huang
Rapid and visual detection of the chemical compositions of plant seeds is important but difficult for a traditional seed quality analysis system. In this study, a custom-designed line-scan Raman hyperspectral imaging system was applied for detecting and displaying the main chemical compositions in a heterogeneous maize seed. Raman hyperspectral images collected from the endosperm and embryo of maize seed were acquired and preprocessed by Savitzky-Golay (SG) filter and adaptive iteratively reweighted Penalized Least Squares (airPLS)...
April 13, 2018: Spectrochimica Acta. Part A, Molecular and Biomolecular Spectroscopy
https://www.readbyqxmd.com/read/29680124/spore-germination-of-pathogenic-filamentous-fungi
#15
Poppy C S Sephton-Clark, Kerstin Voelz
Fungi, algae, plants, protozoa, and bacteria are all known to form spores, especially hardy and ubiquitous propagation structures that are also often the infectious agents of diseases. Spores can survive for thousands of years, frozen in the permafrost (Kochkina et al., 2012), with the oldest viable spores extracted after 250 million years from salt crystals (Vreeland, Rosenzweig, & Powers, 2000). Their resistance to high levels of UV, desiccation, pressure, heat, and cold enables the survival of spores in the harshest conditions (Setlow, 2016)...
2018: Advances in Applied Microbiology
https://www.readbyqxmd.com/read/29679313/effects-of-different-natural-extracts-in-an-experimental-model-of-benign-prostatic-hyperplasia-bph
#16
Irene Paterniti, Michela Campolo, Marika Cordaro, Rosalba Siracusa, Antonio Filippone, Emanuela Esposito, Salvatore Cuzzocrea
OBJECTIVE AND DESIGN: To characterize the impact of inflammatory process and oxidative stress in the degree of benign prostatic hyperplasia (BPH), a common condition in which chronic inflammation plays a crucial role, we investigated the effect of different plant extract preparations in an in vivo model of BPH as new therapeutic target. MATERIAL: BPH was made in rats with daily administration of testosterone propionate (3 mg/kg) for 14 days. TREATMENT: Rats were randomized into different groups to receive oral administration of plant extract preparations: Serenoa repens with selenium (SeR 28...
April 20, 2018: Inflammation Research: Official Journal of the European Histamine Research Society ... [et Al.]
https://www.readbyqxmd.com/read/29679156/phthalates-removal-efficiency-in-different-wastewater-treatment-technology-in-the-eastern-cape-south-africa
#17
Taofeek Salaudeen, Omobola Okoh, Foluso Agunbiade, Anthony Okoh
The removal capacity of different wastewater treatment plant (WWTP) technologies adopted in rural areas for phthalate was investigated in the Eastern Cape, South Africa. Wastewater samples collected from three selected WWTPs which use activated sludge (AS), trickling filter (TF), and oxidation pond (OP) technology were extracted using the solid-phase extraction method followed by gas chromatography-mass spectrometry (GC-MS) analysis. The six selected phthalate esters (PAEs) dimethyl phthalate (DMP), diethyl phthalate (DEP), di-n-butyl phthalate (DBP), benzyl butyl phthalate (BBP), di(2-ethyl hexyl) phthalate (DEHP), and di-n-octyl phthalate (DOP) were detected in all the samples collected from the WWTPs...
April 20, 2018: Environmental Monitoring and Assessment
https://www.readbyqxmd.com/read/29679041/a-new-protein-tyrosine-phosphatase-1b-inhibitory-%C3%AE-pyrone-type-polyketide-from-okinawan-plant-associated-aspergillus-sp-tmpu1623
#18
Hiroyuki Yamazaki, Kenta Takahashi, Natsuki Iwakura, Tatsuki Abe, Masanari Akaishi, Satomi Chiba, Michio Namikoshi, Ryuji Uchida
A new polyenyl-α-pyrone polyketide, aspopyrone A (1), was isolated from a culture broth of Okinawan plant-associated Aspergillus sp. TMPU1623 by solvent extraction, ODS column chromatography, and preparative HPLC (ODS). The structure of 1 was assigned based on NMR experiments. Compound 1 exhibited protein tyrosine phosphatase (PTP) 1B and T-cell PTP (TCPTP) inhibitory activities with IC50 values of 6.7 and 6.0 μM, respectively.
April 20, 2018: Journal of Antibiotics
https://www.readbyqxmd.com/read/29678768/safety-assessment-of-ethanolic-extract-of-olea-europaea-l-leaves-after-acute-and-subacute-administration-to-wistar-rats
#19
Camille Gaube Guex, Fernanda Ziegler Reginato, Kássia Caroline Figueredo, Andreia Regina Haas da Silva, Fernanda Brum Pires, Roberta da Silva Jesus, Cibele Lima Lhamas, Gilberti Helena Hübscher Lopes, Liliane de Freitas Bauermann
Olea europaea L., popularly known as olive, is a plant widely used worldwide. Its leaves, fruit and oil are extensively consumed and present important pharmacological properties. However, studies regarding the toxicity of olive leaves are still limited in the literature. Therefore, the aim of the study was to investigate acute and subacute oral toxicities of the ethanolic extract of olive leaves (EEO) in Wistar rats through histopathology and biochemical and hematological parameters. Acute toxicity was assessed using a single dose of 2000 mg/kg of EEO administered by oral gavage to male and female rats...
April 17, 2018: Regulatory Toxicology and Pharmacology: RTP
https://www.readbyqxmd.com/read/29678407/determination-of-nine-bisphenols-in-sewage-and-sludge-using-dummy-molecularly-imprinted-solid-phase-extraction-coupled-with-liquid-chromatography-tandem-mass-spectrometry
#20
Xiaoli Sun, Junyu Peng, Muhua Wang, Jincheng Wang, Chunlan Tang, Luoxing Yang, Hua Lei, Fang Li, Xueli Wang, Jiping Chen
This paper describes the determination of bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF), bisphenol E (BPE), bisphenol B (BPB), bisphenol AF (BPAF), bisphenol AP (BPAP), bisphenol Z (BPZ) and tetrabromobisphenol A (TBBPA) in sewage and sludge samples. A highly class-selective dummy molecularly imprinted polymer was used for solid phase extraction (SPE) and clean-up of the samples. Bisphenols was quantified by high-performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS). The developed method had acceptable recoveries (43...
April 3, 2018: Journal of Chromatography. A
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