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https://www.readbyqxmd.com/read/29049977/syk-gtp-rac-1-mediated-immune-stimulatory-effect-of-cuscuta-epithymum-ipomoea-batata-and-euphorbia-hirta-plant-extracts
#1
Vanitha Sagar Sudam, Ajay Godwin Potnuri, N J Prameela Subhashini
Polymorphonuclear neutrophils (PMNn) are the pivotal mediators of phagocytosis. In addition to neutropenia, impaired neutrophilic function is associated with pathological conditions and immuno-deficiencies. Henceforth, Immuno-stimulatory strategies targeting neutrophilic function are indeed powerful tools in combating obstinate infections. In appreciation towards the usefulness of herbal medicines in therapeutic scenario, the present study was carried out to analyse the immuno-stimulatory effect of Cuscuta epithymum, Ipomoea batata and Euphorbia hirta using in-vitro and in-vivo rodent experimental models...
October 16, 2017: Biomedicine & Pharmacotherapy, Biomédecine & Pharmacothérapie
https://www.readbyqxmd.com/read/29049350/an-integrative-in-silico-approach-for-therapeutic-target-identification-in-the-human-pathogen-corynebacterium-diphtheriae
#2
Syed Babar Jamal, Syed Shah Hassan, Sandeep Tiwari, Marcus V Viana, Leandro de Jesus Benevides, Asad Ullah, Adrián G Turjanski, Debmalya Barh, Preetam Ghosh, Daniela Arruda Costa, Artur Silva, Richard Röttger, Jan Baumbach, Vasco A C Azevedo
Corynebacterium diphtheriae (Cd) is a Gram-positive human pathogen responsible for diphtheria infection and once regarded for high mortalities worldwide. The fatality gradually decreased with improved living standards and further alleviated when many immunization programs were introduced. However, numerous drug-resistant strains emerged recently that consequently decreased the efficacy of current therapeutics and vaccines, thereby obliging the scientific community to start investigating new therapeutic targets in pathogenic microorganisms...
2017: PloS One
https://www.readbyqxmd.com/read/29049338/growing-plants-on-oily-nutrient-poor-soil-using-a-native-symbiotic-fungus
#3
Timothy S Repas, D Michael Gillis, Zakia Boubakir, Xiaohui Bao, Gary J Samuels, Susan G W Kaminskyj
The roots of land plants associate with microbes, including fungal symbionts that can confer abiotic stress tolerance. Bitumen extraction following oil-sand surface mining in the Athabasca region of Alberta, Canada removes plant nutrients but leaves a petrochemical residue, making the coarse tailings (CT) hostile to both plants and microbes. We isolated an endophyte strain of the Ascomycete Trichoderma harzianum we call TSTh20-1 (hereafter, TSTh) from a dandelion that was naturally growing on CT. TSTh colonization allowed tomato, wheat, and remediation seed mixtures to germinate and their seedlings to flourish on CT without the use of fertilizer...
2017: PloS One
https://www.readbyqxmd.com/read/29049321/determination-and-production-of-antimicrobial-compounds-by-aspergillus-clavatonanicus-strain-mj31-an-endophytic-fungus-from-mirabilis-jalapa-l-using-uplc-esi-ms-ms-and-td-gc-ms-analysis
#4
Vineet Kumar Mishra, Ajit Kumar Passari, Preeti Chandra, Vincent Vineeth Leo, Brijesh Kumar, Sivakumar Uthandi, Sugitha Thankappan, Vijai Kumar Gupta, Bhim Pratap Singh
Endophytic fungi associated with medicinal plants are reported as potent producers of diverse classes of secondary metabolites. In the present study, an endophytic fungi, Aspergillus clavatonanicus strain MJ31, exhibiting significant antimicrobial activity was isolated from roots of Mirabilis jalapa L., was identified by sequencing three nuclear genes i.e. internal transcribed spacers ribosomal RNA (ITS rRNA), 28S ribosomal RNA (28S rRNA) and translation elongation factor 1- alpha (EF 1α). Ethyl acetate extract of strain MJ31displayed significant antimicrobial potential against Bacillus subtilis, followed by Micrococccus luteus and Staphylococcus aureus with minimum inhibitory concentrations (MIC) of 0...
2017: PloS One
https://www.readbyqxmd.com/read/29048892/antiplasmodial-chromanes-and-chromenes-from-the-monotypic-plant-species-koeberlinia-spinosa
#5
Christopher Charles Presley, Ana Lisa Valenciano, Maria L Fernández-Murga, Yongle Du, Narasimhamurthy Shanaiah, Maria B Cassera, Michael Goetz, Jason A Clement, David G I Kingston
Nine new compounds containing either a chromane or chromene ring moiety were isolated from the monotypic plant Koeberlinia spinosa. Compounds 1-4 are chromanes with all possible E and Z isomers of the isoprenoid side chain, with compound 5 a methylated derivative of 1. Compounds 6 and 7 were assigned as diastereomeric cyclized derivatives of 2 and were probably artifacts formed during the extraction or the isolation processes. Compounds 8 and 9 were characterized as new chromenes. Structure elucidation of 1-9 was conducted via 1D and 2D NMR spectroscopic data interpretation, and absolute configurations were determined by ECD spectroscopic analysis...
October 19, 2017: Journal of Natural Products
https://www.readbyqxmd.com/read/29048861/-separation-and-purification-of-acteoside-from-rehmannia-glutinosa-by-combining-macroporous-resin-with-high-speed-countercurrent-chromatography
#6
Zhisi Bu, Qing He, Rushi Zhao, Chu Chu, Xingnuo Li, Shengqiang Tong
Acteoside,a chemical component of the traditional Chinese medicinal herb Rehmannia glutinosa,was separated from the plant by a combination of macroporous resin column chromatography and high-speed countercurrent chromatography.The static adsorption and desorption of acteoside in the crude extract were in-vestigated using four kinds of macroporous resin,among which the D101 macroporous resin presented the best adsorption and desorption rates toward the compound.The crude extract was then gradient-eluted with increa-sing volume percentages of ethanol,where it was found that the highest content of acteoside was obtained when using 10%(v/v) ethanol eluent,in which the purity of acteoside was increased from 4...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048854/-determination-of-the-plant-growth-regulators-in-batatas-by-matrix-solid-phase-dispersive-extraction-and-high-performance-liquid-chromatography-with-tandem-mass-spectrometry
#7
Jing Zhang, Huihui Wan, Hua Zhang
An analytical method based on matrix solid-phase dispersive (MSPD) extraction and high performance liquid chromatography-tandem mass spectrometry (HPLC-MS/MS) was established for the determination of forchlorfenuron, 6-benzylaminopurine (6-BA), N-(2-ethylhexyl)-5-norbornene-2,3-dicarboximide (MGK 264) and paclobutrazol in batatas. The samples were dispersed with silica by grinding, and then extracted with methanol. The determination was carried out on a Thermo hypersil GOLD C18 column (150 mm×2.1 mm, 5 μm) in gradient elution with mobile phases of methanol and ammonium formate (5 mmol/L, containing 0...
September 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048794/-ionic-liquid-based-ultrasonication-assisted-extraction-of-essential-oil-from-the-leaves-of-persicaria-minor-and-conductor-like-screening-model-for-realistic-solvents-study
#8
Ullah Habib, D Wilfred Cecilia, S Shaharun Maizatul
Ionic liquids (ILs) based ultrasonic-assisted extract has been applied for the extraction of essential oil from Persicaria minor leaves. The effects of temperature, sonication time, and particle size of the plant material on the yield of essential oil were investigated. Among the different ILs employed, 1-ethyl-3-methylimidazolium acetate was the most effective, providing a 9.55% yield of the essential oil under optimum conditions (70 ℃, 25 min, IL:hexane ratio of 7:10 (v/v), particle size 60-80 mesh). The performance of 1-ethyl-3-methylimidazolium acetate in the extraction was attributed to its low viscosity and ability to disintegrate the structural matrix of the plant material...
June 8, 2017: Se Pu, Chinese Journal of Chromatography
https://www.readbyqxmd.com/read/29048336/proanthocyanidin-characterization-antioxidant-and-cytotoxic-activities-of-three-plants-commonly-used-in-traditional-medicine-in-costa-rica-petiveria-alliaceae-l-phyllanthus-niruri-l-and-senna-reticulata-willd
#9
Mirtha Navarro, Ileana Moreira, Elizabeth Arnaez, Silvia Quesada, Gabriela Azofeifa, Diego Alvarado, Maria J Monagas
The phenolic composition of aerial parts from Petiveria alliaceae L., Phyllanthus niruri L. and Senna reticulata Willd., species commonly used in Costa Rica as traditional medicines, was studied using UPLC-ESI-TQ-MS on enriched-phenolic extracts. Comparatively, higher values of total phenolic content (TPC), as measured by the Folin-Ciocalteau method, were observed for P. niruri extracts (328.8 gallic acid equivalents/g) than for S. reticulata (79.30 gallic acid equivalents/g) whereas P. alliaceae extract showed the lowest value (13...
October 19, 2017: Plants (Basel, Switzerland)
https://www.readbyqxmd.com/read/29047086/natural-antioxidants-as-potential-therapy-and-a-promising-role-for-melatonin-against-pulmonary-hypertension
#10
Gerald J Maarman
Plasma and serum samples, and lung/heart tissue of pulmonary hypertension (PH) patients and animal models of PH display elevated oxidative stress. Moreover, the severity of PH and levels of oxidative stress increase concurrently, which suggests that oxidative stress could be utilized as a biomarker for PH progression. Accumulating evidence has well established that oxidative stress is also key role player in the development of PH. Preclinical studies have demonstrated that natural antioxidants improved PH condition, and, therefore, antioxidant therapy has been proposed as a potential therapeutic strategy against PH...
2017: Advances in Experimental Medicine and Biology
https://www.readbyqxmd.com/read/29046938/is-there-a-negative-association-between-the-content-of-condensed-tannins-total-phenols-and-total-tannins-of-tropical-plant-extracts-and-in-vitro-anthelmintic-activity-against-haemonchus-contortus-eggs
#11
G S Castañeda-Ramírez, J F J Torres-Acosta, C A Sandoval-Castro, P G González-Pech, V P Parra-Tabla, C Mathieu
In vitro studies using plant extracts suggest a relationship between their polyphenol contents and their anthelmintic (AH) activity against Haemonchus contortus. High polyphenol content appears to increase the efficacy of plant extracts against H. contortus as assessed by the larval exsheathment inhibition assay (LEIA) while appearing to reduce the AH efficacy measured using the egg hatch assay (EHA). In addition, some plants lack AH activity. Therefore, the present study investigated the relationship between the contents of condensed tannins (CT), total phenols (TP), and total tannins (TT) in methanol:water extracts (70:30) obtained from ten tropical plant species consumed by small ruminants as well as their AH activity against H...
October 18, 2017: Parasitology Research
https://www.readbyqxmd.com/read/29046693/antibacterial-activity-of-essential-oil-from-lavender-lavandula-angustifolia-against-pet-turtle-borne-pathogenic-bacteria
#12
Sabrina Hossain, Honghoi Heo, B C J De Silva, S H M P Wimalasena, H N K S Pathirana, Gang-Joon Heo
Pet turtles are well-known to harbor an array of bacterial pathogens which can cause zoonotic infections in humans as well as opportunistic infections in the turtles itself. Essential oils are the natural plant extracts which have been traditionally used for disease treatment. In the present study, the essential oil of lavender (EOL) was examined for its antibacterial activity against thirty-eight strains of turtle-borne pathogenic bacteria belonging to seven species; Aeromonas hydrophila, A. caviae, A. dhakensis, Citrobacter freundii, Proteus mirabilis, Salmonella enterica and Pseudomonas aeruginosa...
September 2017: Laboratory Animal Research
https://www.readbyqxmd.com/read/29046296/geraniin-is-a-diuretic-by-inhibiting-the-na-k-2cl-cotransporter-nkcc2
#13
Erika Moreno, Juan A Gayosso, Jose Ramón Montejano, Georgina Almaguer, Norma Vázquez, Cristino Cruz, Adriana Mercado, Norma A Bobadilla, Gerardo Gamba, Alfredo Sierra, Victoria Ramírez
Geranium seemannii Peyr is a perennial plant endemic in central Mexico that has been widely used for its diuretic effect, but the responsible compound of this effect is unknown as well as the mechanism by which the diuretic effect is achieved. Geraniin is one of the compounds isolated from this kind of geranium. This study was designed to determinate whether geraniin possesses diuretic activity and to elucidate the mechanism of action. Geraniin was extracted and purified from Geranium seemannii Peyr. Male Wistar rats were divided into four groups: 1) Control, 2) 75 mg/kg of geraniin, 3) 20 mg/Kg of furosemide, and 4) 10 mg/Kg of hydrochlorothiazide...
October 18, 2017: American Journal of Physiology. Renal Physiology
https://www.readbyqxmd.com/read/29046164/colchicine-a-review-about-chemical-structure-and-clinical-using
#14
Hourieh Alkadi, Mohamad Jowad Khubeiz
For many years, colchicine has been used for therapeutic purposes and has been given considerable attention because of its association with tubulin and inhibition of small tubular polymerization. Colchicine is an alkaloids extracted from the colchicum autumnale plant, and it contains a molecular formula C22H25NO6, and it consists of three rings. Many studies have concerned with structural changes, in order to increase their pharmacological effectiveness and to reduce the side effects of toxicity arising from it...
October 17, 2017: Infectious Disorders Drug Targets
https://www.readbyqxmd.com/read/29045823/traditional-uses-phytochemistry-and-pharmacological-properties-of-african-nauclea-species-a-review
#15
REVIEW
Romain Haudecoeur, Marine Peuchmaur, Basile Pérès, Maxime Rome, Germain Sotoing Taïwe, Ahcène Boumendjel, Benjamin Boucherle
ETHNOPHARMACOALOGICAL RELEVANCE: The genus Nauclea in Africa comprises seven species. Among them, N. latifolia, N. diderrichii and N. pobeguinii are widely used by the local population in traditional remedies. Preparation from various parts of plants (e.g. roots, bark, leaves) are indicated by traditional healers for a wide range of diseases including malaria, pain, digestive ailments or metabolic diseases. MATERIALS AND METHODS: A literature search was conducted on African species of the genus Nauclea using scientific databases such as Google Scholar, Pubmed or SciFinder...
October 15, 2017: Journal of Ethnopharmacology
https://www.readbyqxmd.com/read/29045613/genome-structure-of-rosa-multiflora-a-wild-ancestor-of-cultivated-roses
#16
Noriko Nakamura, Hideki Hirakawa, Shusei Sato, Shungo Otagaki, Shogo Matsumoto, Satoshi Tabata, Yoshikazu Tanaka
The draft genome sequence of a wild rose (Rosa multiflora Thunb.) was determined using Illumina MiSeq and HiSeq platforms. The total length of the scaffolds was 739,637,845 bp, consisting of 83,189 scaffolds, which was close to the 711 Mbp length estimated by k-mer analysis. N50 length of the scaffolds was 90,830 bp, and extent of the longest was 1,133,259 bp. The average GC content of the scaffolds was 38.9%. After gene prediction, 67,380 candidates exhibiting sequence homology to known genes and domains were extracted, which included complete and partial gene structures...
October 16, 2017: DNA Research: An International Journal for Rapid Publication of Reports on Genes and Genomes
https://www.readbyqxmd.com/read/29045235/the-aqueous-tuber-extract-of-pueraria-tuberosa-willd-d-c-caused-cytotoxic-effect-on-ht-29-cell-lines-with-down-regulation-of-nuclear-factor-kappa-b-nf-%C3%AE%C2%BAb
#17
Adeolu Alex Adedapo, Olusegun A Fagbohun, Christianah Dawurung, Ademola Adetokunbo Oyagbemi, Temidayo Olutayo Omobowale, Momoh Audu Yakubu
Background Pueraria tuberosa (Willd) D.C. (Fabaceae) tubers are already used in traditional medicine by Ayurvedic physicians for the management of fertility disorders, general weakness, and also as anti-ageing therapies. Other known pharmacological properties include: anti-hyperglycemics, hepatoprotective, anti-hyperlipidemic, diuretic, nutritive, and anti-fertility agents in male rats. Methods The anti-proliferative effect of the aqueous tuberous root extract of Pueraria tuberosa on vascular smooth muscle cells (VSMCs) and Human Colorectal Adenocarcinoma Cell lines (HT-29) was investigated using the Cell Titer 96 MTT Proliferation Assay where the viable cells were seeded at a density of 5 × 104 (100 µL/well)...
October 18, 2017: Journal of Complementary & Integrative Medicine
https://www.readbyqxmd.com/read/29044981/use-of-biocontrol-agents-and-botanicals-in-integrated-management-of-botrytis-cinerea-in-table-grape-vineyards
#18
Caterina Rotolo, Rita M De Miccolis Angelini, Crescenza Dongiovanni, Stefania Pollastro, Giulio Fumarola, Michele Di Carolo, Donato Perrelli, Patrizia Natale, Francesco Faretra
BACKGROUND: The increasing interest on biological control agents (BCAs) and botanicals (BOTs) is due to the increasing awareness on environmental and human health risks associated to the usage of synthetic plant protection products. The BCAs Bacillus subtilis strain QST713, Bacillus amyloliquefaciens strain D747 and Aureobasidium pullulans strains DSM14940 and DSM14941, and the BOTs Melaleuca alternifolia and terpenic extracts are proposed for the control of grey mould in vineyard. This study was aimed at evaluating their effectiveness in integrated crop management strategies and their outcomes in terms of management of fungicide resistance and residues...
October 17, 2017: Pest Management Science
https://www.readbyqxmd.com/read/29044865/quick-identification-of-piperidine-alkaloid-from-roots-of-grewia-nervosa-and-their-glucosidase-inhibitory-activity
#19
Surya N Meena, Mahesh S Majik, Sanjeev C Ghadi, Santosh G Tilve
Grewia nervosa is herbal plant used as traditional medicine for different purposes. Bioassay-guided chemical fractionation of G. nervosa roots resulted in an identification of two known and one new compound, named Microgrewiapine A, Homomicrogrewiapine and N-methyl-microcosamine respectively. Their structures were determined using combination of LC-HRMS, (1) H NMR and IR spectra analyses followed by comparison with those reported in the literature. The problematic separation of these alkaloids on traditional column chromatography (Silica gel, Octadecyl silane (ODS), Sephadex) was resolved by using HPLC method...
October 16, 2017: Chemistry & Biodiversity
https://www.readbyqxmd.com/read/29044771/alkaloids-of-amaryllidaceae-as-inhibitors-of-cholinesterases-aches-and-bches-an-integrated-bioguided-study
#20
Natalie Cortes, Karina Sierra, Fernando Alzate, Edison H Osorio, Edison Osorio
INTRODUCTION: Enzymatic inhibition of acetylcholinesterase (AChE) is an essential therapeutic target for the treatment of Alzheimer's disease (AD) and AChE inhibitors are the first-line drugs for it treatment. However, butyrylcholinesterase (BChE), contributes critically to cholinergic dysfunction associated with AD. Thus, the development of novel therapeutics may involve the inhibition of both cholinesterase enzymes. OBJECTIVE: To evaluate, in an integrated bioguided study, cholinesterases alkaloidal inhibitors of Amaryllidaceae species...
October 17, 2017: Phytochemical Analysis: PCA
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