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https://www.readbyqxmd.com/read/29793195/alcohol-and-drugs-use-among-drivers-injured-in-road-accidents-in-campania-italy-a-8-years-retrospective-analysis
#1
Anna Carfora, Carlo Pietro Campobasso, Paola Cassandro, Raffaella Petrella, Renata Borriello
A recent update of the Italian Road Traffic Law (RTL 41/2016), established severe penal sanctions when drivers, driving under the influence of alcohol (DUI) or drugs (DUID), are involved in road accident that results in death or injuries. A study was carried out to assess the trends of consumption of alcohol, illicit drugs or pharmaceutical among injured drivers suspected for DUI or DUID from 2009 to 2016 in the region of Campania (Italy). Confirmation toxicological analyses were performed on 780 blood samples and 1017 urine samples collected from 1797 injured drivers...
May 9, 2018: Forensic Science International
https://www.readbyqxmd.com/read/29793157/energy-dissipation-in-quasi-linear-viscoelastic-tissues-cells-and-extracellular-matrix
#2
Behzad Babaei, A J Velasquez-Mao, Kenneth M Pryse, William B McConnaughey, Elliot L Elson, Guy M Genin
Characterizing how a tissue's constituents give rise to its viscoelasticity is important for uncovering how hidden timescales underlie multiscale biomechanics. These constituents are viscoelastic in nature, and their mechanics must typically be assessed from the uniaxial behavior of a tissue. Confounding the challenge is that tissue viscoelasticity is typically associated with nonlinear elastic responses. Here, we experimentally assessed how fibroblasts and extracellular matrix (ECM) within engineered tissue constructs give rise to the nonlinear viscoelastic responses of a tissue...
May 21, 2018: Journal of the Mechanical Behavior of Biomedical Materials
https://www.readbyqxmd.com/read/29793126/effect-of-manual-therapy-versus-proprioceptive-neuromuscular-facilitation-in-dynamic-balance-mobility-and-flexibility-in-field-hockey-players-a-randomized-controlled-trial
#3
Gemma V Espí-López, Susana López-Martínez, Marta Inglés, Pilar Serra-Añó, Marta Aguilar-Rodríguez
OBJECTIVES: To compare the effectiveness of a specific Manual Therapy (MT) protocol applied to field hockey players (FHP), versus a Proprioceptive Neuromuscular Facilitation (PNF) protocol, in the improvement of dynamic balance, active range of movement and lumbar flexibility one-week and four-weeks after the treatment. DESIGN: Randomized controlled trial. Participants were assigned to 2 groups: MT and PNF. 30 min' sessions were performed once a week for three weeks...
April 22, 2018: Physical Therapy in Sport
https://www.readbyqxmd.com/read/29793088/decellularized-and-matured-esophageal-scaffold-for-circumferential-esophagus-replacement-proof-of-concept-in-a-pig-model
#4
Guillaume Luc, Guillaume Charles, Caroline Gronnier, Magali Cabau, Charlotte Kalisky, Mallory Meulle, Reine Bareille, Samantha Roques, Lionel Couraud, Johanna Rannou, Laurence Bordenave, Denis Collet, Marlène Durand
Surgical resection of the esophagus requires sacrificing a long portion of it. Its replacement by the demanding gastric pull-up or colonic interposition techniques may be avoided by using short biologic scaffolds composed of decellularized matrix (DM). The aim of this study was to prepare, characterize, and assess the in vivo remodeling of DM and its clinical impact in a preclinical model. A dynamic chemical and enzymatic decellularization protocol of porcine esophagus was set up and optimized. The resulting DM was mechanically and biologically characterized by DNA quantification, histology, and histomorphometry techniques...
May 17, 2018: Biomaterials
https://www.readbyqxmd.com/read/29792974/patient-compliance-with-maintenance-intravesical-therapy-for-non-muscle-invasive-bladder-cancer
#5
Shlomi Tapiero, Alexander Helfand, Daniel Kedar, Ofer Yossepowitch, Andrei Nadu, Jack Baniel, David Lifshitz, David Margel
OBJECTIVE: To assess patient adherence to intravesical instillation therapy for non-muscle invasive urothelial carcinoma outside of clinical trials. METHODS: We reviewed the records of patients from 2000-2013 who received intravesical therapy for non-muscle invasive urothelial carcinoma. Patients with evidence of tumor recurrence or progression were excluded. We performed univariable and multivariable regression analysis to predict adherence to intravesical therapy...
May 21, 2018: Urology
https://www.readbyqxmd.com/read/29792943/the-development-of-a-screening-protocol-for-salmonella-spp-and-enteropathogenic-yersinia-spp-in-samples-from-wild-boar-sus-scrofa-also-generating-mlva-data-for-y-enterocolitica-and-y-pseudotuberculosis
#6
Axel Sannö, Magdalena Jacobson, Sandra Sterner, Susanne Thisted-Lambertz, Anna Aspán
Salmonellosis and yersiniosis are notifiable human diseases that are commonly associated with contaminated food. Domestic pigs as well as wild boars and other wild-life have been identified as reservoirs of these bacteria. Methods for cultivation and molecular epidemiological investigations of Salmonella spp. are well established, however, cultivation of enteropathogenic Yersinia spp. is time- consuming and the commonly used method for molecular epidemiological investigations, pulsed-field gel electrophoresis, lack in discriminatory power...
May 21, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29792942/optimisation-of-decontamination-method-and-influence-of-culture-media-on-the-recovery-of-mycobacterium-avium-subspecies-paratuberculosis-from-spiked-water-sediments
#7
G Aboagye, M T Rowe
The recovery of Mycobacterium avium subspecies paratuberculosis (Map) from the environment can be a laborious process - owing to Map being fastidious, its low number, and also high numbers of other microbial populations in such settings. Protocols i.e. filtration, decontamination and modified elution were devised to recover Map from spiked water sediments. Three culture media: Herrold's Egg Yolk Media (HEYM), Middlebrook 7H10 (M-7H10) and Bactec 12B were then employed to grow the organism following its elution...
May 21, 2018: Journal of Microbiological Methods
https://www.readbyqxmd.com/read/29792940/a-randomized-control-trial-to-determine-the-effectiveness-and-physiological-effects-of-spinal-manipulation-and-spinal-mobilization-compared-to-each-other-and-a-sham-condition-in-patients-with-chronic-low-back-pain-study-protocol-for-the-relief-study
#8
Brian C Clark, David W Russ, Masato Nakazawa, Christopher R France, Stevan Walkowski, Timothy D Law, Megan Applegate, Niladri Mahato, Samuel Lietkam, James Odenthal, Daniel Corcos, Simeon Hain, Betty Sindelar, Robert J Ploutz-Snyder, James S Thomas
BACKGROUND: Low back pain (LBP) is one of the most common reasons for seeking medical care. Manipulative therapies are a common treatment for LBP. Few studies have compared the effectiveness of different types of manipulative therapies. Moreover, the physiologic mechanisms underlying these treatments are not fully understood. Herein, we present the study protocol for The Researching the Effectiveness of Lumbar Interventions for Enhancing Function Study (The RELIEF Study). METHODS AND STUDY DESIGN: The RELIEF Study is a Phase II RCT with a nested mechanistic design...
May 21, 2018: Contemporary Clinical Trials
https://www.readbyqxmd.com/read/29792937/a-reliable-targeted-next-generation-sequencing-strategy-for-diagnosis-of-myopathies-and-muscular-dystrophies-especially-for-the-giant-titin-and-nebulin-genes
#9
Reda Zenagui, Delphine Lacourt, Henri Pegeot, Kevin Yauy, Raul Juntas Morales, Corine Theze, François Rivier, Claude Cances, Guilhem Sole, Dimitri Renard, Ulrike Walther-Louvier, Xavier Ferrer-Monasterio, Caroline Espil, Marie-Christine Arné-Bes, Pascal Cintas, Emmanuelle Uro-Coste, Marie-Laure Martin Negrier, Valérie Rigau, Eric Bieth, Cyril Goizet, Mireille Claustres, Michel Koenig, Mireille Cossée
Myopathies and muscular dystrophies (M-MDs) are genetically heterogeneous diseases, with more than 100 identified genes, including the giant and complex titin (TTN) and nebulin (NEB) genes. Next-generation sequencing technology revolutionized M-MD diagnosis and revealed high frequency of TTN and NEB variants. We developed a next-generation sequencing diagnostic strategy targeted on the coding sequences of 135 M-MD genes. Comparison of two targeted capture technologies (SeqCap EZ Choice library capture kit (Roche-Nimblegen) and Nextera Rapid Capture Custom Enrichment kit (Illumina)) and of two whole exome sequencing kits (SureSelect V5 (Agilent) and TruSeq RapidExome capture (Illumina)) revealed best coverage with the SeqCap EZ Choice protocol...
May 21, 2018: Journal of Molecular Diagnostics: JMD
https://www.readbyqxmd.com/read/29792780/cardiovascular-screening-practices-and-attitudes-from-the-ncaa-autonomous-power-5-conferences
#10
Christopher W Miars, Andreas Stamatis, Grant B Morgan, Jonathan A Drezner
BACKGROUND: The development of athlete-specific electrocardiogram (ECG) interpretation standards, along with recent rates of sudden cardiac death (SCD) in athletes being higher than previously estimated, has heightened the debate in the sports medicine community regarding cardiovascular screening of the college athlete, including whether certain high-risk subsets, such as male basketball athletes, should undergo more intensive screening. HYPOTHESIS: ECG and/or echocardiography screening in National Collegiate Athletic Association Autonomous 5 Division I (A5DI) schools will be more common than previous reports, and there will be more frequent use of noninvasive cardiac screening for men's basketball players than the general athlete population...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29792776/prevalence-of-inadequate-immunity-to-measles-mumps-rubella-and-varicella-in-mlb-and-nba-athletes
#11
Justin J Conway, Brett G Toresdahl, Daphne I Ling, Nicole T Boniquit, Lisa R Callahan, James J Kinderknecht
BACKGROUND: Multiple outbreaks of vaccine-preventable viral diseases have occurred in professional sports in recent years. Currently, there is no established protocol for vaccination or immunity screening for professional athletes. HYPOTHESIS: There are significant differences in the prevalence of inadequate immunity dependent on age, sport, country of birth, and participation in collegiate sports. STUDY DESIGN: Cross-sectional cohort study...
May 1, 2018: Sports Health
https://www.readbyqxmd.com/read/29792736/overutilization-of-health-care-resources-for-breast-pain
#12
Anne C Kushwaha, Kyungmin Shin, Megan Kalambo, Ravinder Legha, Karen E Gerlach, Megha Madhukar Kapoor, Wei T Yang
OBJECTIVE: The objective of this study is to analyze the incidence of women with breast pain who present to an imaging center and assess the imaging findings, outcomes, and workup costs at breast imaging centers affiliated with one institution. MATERIALS AND METHODS: Demographic characteristics of and imaging findings for female patients presenting with breast pain at three community breast imaging centers between January 1, 2014, and December 31, 2014, were reviewed...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792728/single-acquisition-triple-bolus-dual-energy-ct-protocol-for-comprehensive-evaluation-of-renal-masses-a-single-center-randomized-noninferiority-trial
#13
Dinesh Manoharan, Sanjay Sharma, Chandan J Das, Rajeev Kumar, Geetika Singh, Pratik Kumar
OBJECTIVE: The primary objective of this study was to compare triple-bolus dual-energy CT (DECT) against standard triple-phase MDCT in terms of appropriateness of patient treatment. SUBJECTS AND METHODS: One hundred twenty-four patients with suspected renal masses seen at ultrasound were randomized into triple-bolus DECT and triple-phase MDCT groups. Patients in the triple-bolus DECT group underwent synchronous corticomedullary nephrographic delayed-phase triple-bolus DECT...
May 24, 2018: AJR. American Journal of Roentgenology
https://www.readbyqxmd.com/read/29792720/-experimental-processing-of-corrosion-casts-of-large-animal-organs
#14
R Pálek, V Liška, L Eberlová, H Mírka, M Svoboda, S Haviar, M Emingr, O Brzoň, P Mik, V Třeška
INTRODUCTION: Corrosion casts (CCs) are used for the visualization and assessment of hollow structures. CCs with filled capillaries enable (with the help of imaging methods) to obtain data for mathematical organ perfusion modelling. As the processing is more difficult in case of organs with greater volume of the vasculature, mainly organs from small animals have been cast up to now. The aim of this study was to optimize the protocol of corrosion casting of different organs of pig. Porcine organs are relatively easily accessible and frequently used in experimental medicine...
2018: Rozhledy V Chirurgii: Měsíčník Československé Chirurgické Společnosti
https://www.readbyqxmd.com/read/29792562/combined-effects-and-cross-interactions-of-different-antibiotics-and-polypeptides-in-salmonella-bredeney
#15
Xiangyu Ju, Mengjiao Zhu, Jinzhi Han, Zhaoxin Lu, Haizhen Zhao, Xiaomei Bie
Salmonella spp. are health-threatening foodborne pathogens. The increasingly common spread of antibiotic-resistant Salmonella spp. is a major public healthcare issue worldwide. In this study, we wished to explore (1) antibiotic or polypeptide combinations to inhibit multidrug-resistant Salmonella bredeney and (2) the regulation of cross-resistance and collateral sensitivity of antibiotics and polypeptides. We undertook a study to select antibiotic combinations. Then, we promoted drug-resistant strains of S...
May 24, 2018: Microbial Drug Resistance: MDR: Mechanisms, Epidemiology, and Disease
https://www.readbyqxmd.com/read/29792536/outcomes-in-paediatric-external-dacryocystorhinostomy-a-single-centre-experience
#16
Tarjani Vivek Dave, Edak Ezeanosike, Milind N Naik, Mohammad Javed Ali
PURPOSE: To report the outcomes of external dacryocystorhinostomy (Ext DCR) in paediatric patients. METHODS: A single-centre, retrospective, interventional, non-comparative case series was performed on all paediatric patients who underwent Ext DCR between July 2010 and July 2014. Surgery was performed as per standard Ext DCR protocols with only anterior flap suturing. Data collected include demographics, clinical presentations, primary diagnosis, associated systemic anomalies, past interventions, indications for the surgery, use of adjuvants, intraoperative and post-operative complications, aetiology of DCR failure, anatomical and functional successes...
May 24, 2018: Orbit
https://www.readbyqxmd.com/read/29792532/the-moderating-influence-of-disorder-on-coached-overreporting-using-the-mmpi-2-rf
#17
Ariane M Olsen, Carlo O C Veltri
Overreporting has always been a concern within psychological evaluations. The Minnesota Multiphasic Personality Inventory-2-Restructured Form (Ben-Porath & Tellegen, 2008/2011 ) contains validity scales designed for detecting noncredible responses. In this study, 270 undergraduates were instructed to feign either schizophrenia, posttraumatic stress disorder (PTSD) or generalized anxiety disorder (GAD); some participants were coached on symptoms and validity scales. Results at both the individual protocol and mean validity scale score levels suggest that each feigned disorder moderates the effectiveness of coaching on validity scale detection...
May 24, 2018: Journal of Personality Assessment
https://www.readbyqxmd.com/read/29792506/testing-the-validity-of-criminal-risk-assessment-tools-in-sexually-abusive-youth
#18
Steffen Barra, Cornelia Bessler, Markus A Landolt, Marcel Aebi
Although accurate risk appraisals are mandatory to provide effective treatment to juveniles who have sexually offended (JSOs), the current knowledge on the validity of risk assessment instruments for JSOs is inconclusive. We compared the predictive validities of the Juvenile Sex Offender Assessment Protocol II (J-SOAP II), the Estimate of Risk of Adolescent Sexual Offense Recidivism (ERASOR), and the Violence Risk Appraisal Guide-Revised (VRAG-R) scores concerning sexual, nonsexual-violent, and general criminal recidivism (based on both official and nonregistered reoffenses) in a consecutive sample of 597 male JSOs (Mage = 14...
May 24, 2018: Psychological Assessment
https://www.readbyqxmd.com/read/29792448/the-experimental-evidence-for-parapsychological-phenomena-a-review
#19
Etzel Cardeña
This article presents a comprehensive integration of current experimental evidence and theories about so-called parapsychological (psi) phenomena. Throughout history, people have reported events that seem to violate the common sense view of space and time. Some psychologists have been at the forefront of investigating these phenomena with sophisticated research protocols and theory, while others have devoted much of their careers to criticizing the field. Both stances can be explained by psychologists' expertise on relevant processes such as perception, memory, belief, and conscious and nonconscious processes...
May 24, 2018: American Psychologist
https://www.readbyqxmd.com/read/29792403/index-of-microcirculatory-resistance-guided-therapy-with-pressure-controlled-intermittent-coronary-sinus-occlusion-improves-coronary-microvascular-function-and-reduces-infarct-size-in-patients-with-st-elevation-myocardial-infarction-the-oxford-acute-myocardial
#20
Giovanni Luigi De Maria, Mohammad Alkhalil, Alessandra Borlotti, Mathias Wolfrum, Lisa Gaughran, Erica Dall'Armellina, Jeremy P Langrish, Andrew J Lucking, Robin P Choudhury, Rajesh K Kharbanda, Keith M Channon, Adrian P Banning
AIMS: The Oxford Acute Myocardial Infarction PICSO (OxAMI-PICSO) study aimed to assess the efficacy of index of microcirculatory resistance (IMR)-guided therapy with pressure-controlled intermittent coronary sinus occlusion (PICSO) in anterior ST-elevation myocardial infarction (STEMI). METHODS AND RESULTS: Patients with anterior STEMI treated with primary percutaneous coronary intervention (pPCI) were enrolled. Pre-stenting IMR was measured and PICSO treatment delivered if pre-stenting IMR was >40...
May 24, 2018: EuroIntervention
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