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https://www.readbyqxmd.com/read/29145581/prospective-epidemiological-research-studies-in-iran-the-persian-cohort-rationale-objectives-and-design
#1
Hossein Poustchi, Sareh Eghtesad, Farin Kamangar, Arash Etemadi, Abbas-Ali Keshtkar, Azita Hekmatdoost, Zahra Mohammadi, Zahra Mahmoudi, Amaneh Shayanrad, Farzin Roozafzai, Mahdi Sheikh, Alireza Jalaeikhoo, Mohammad Hossein Somi, Fariborz Mansour-Ghanaei, Farid Najafi, Ehsan Bahramali, Amirhoushang Mehrparvar, Alireza Ansari-Moghaddam, Ahmad Ali Enayati, Ali Esmaeili Nadimi, Abbas Rezaianzadeh, Nader Saki, Fatemeh Alipour, Roya Kelishadi, Afarin Rahimi-Movaghar, Nayyereh Aminisani, Paolo Boffetta, Reza Malekzadeh
Non-communicable diseases (NCDs) account for 76% of deaths in Iran and this number is on the rise, parallel to global rates. Many risk factors associated with NCDs are preventable; however it is first necessary to conduct observational studies to identify relevant risk factors, and the most appropriate approach to control them. Iran is a multi-ethnic country, therefore the Ministry of Health and Medical Education sought to launch a nationwide cohort study-the Prospective Epidemiological Research Studies in IrAN (PERSIAN)-in order to identify the most prevalent NCDs among Iranian ethnicities, and to investigate effective methods of prevention...
November 14, 2017: American Journal of Epidemiology
https://www.readbyqxmd.com/read/29145458/a-model-guided-symbolic-execution-approach-for-network-protocol-implementations-and-vulnerability-detection
#2
Shameng Wen, Qingkun Meng, Chao Feng, Chaojing Tang
Formal techniques have been devoted to analyzing whether network protocol specifications violate security policies; however, these methods cannot detect vulnerabilities in the implementations of the network protocols themselves. Symbolic execution can be used to analyze the paths of the network protocol implementations, but for stateful network protocols, it is difficult to reach the deep states of the protocol. This paper proposes a novel model-guided approach to detect vulnerabilities in network protocol implementations...
2017: PloS One
https://www.readbyqxmd.com/read/29145319/primary-myelofibrosis-and-pregnancy-outcomes-after-low-molecular-weight-heparin-administration-a-case-report-and-literature-review
#3
Roxana Elena Bohîlţea, Monica Mihaela Cîrstoiu, Crîngu Antoniu Ionescu, Emilia Niculescu-Mizil, Ana Maria Vlădăreanu, Irina Voican, Mihai Dimitriu, Natalia Turcan
RATIONALE: Primary myelofibrosis is encountered with the myeloproliferative diseases and is the least prevalent among women of childbearing age. The prognosis is guided by pancytopenia, leukemic transformation and thrombosis which are the dominant complications. PATIENT CONCERNS: Data regarding protocol management during pregnancy in the context of myelofibrosis are insufficient. Fewer than ten cases have been described until now and half of this cases have resulted in fetal death due to placental infarction during the second and third trimesters...
November 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/29145166/revisiting-interhemispheric-imbalance-in-chronic-stroke-a-tdcs-study
#4
Alana B McCambridge, James W Stinear, Winston D Byblow
OBJECTIVE: Chronic stroke patients with moderate-severe motor impairment may have an increased reliance on contralesional vs ipsilesional motor areas to control the paretic arm. We hypothesised that increasing contralesional excitability with anodal transcranial direct current stimulation (a-tDCS) would benefit motor performance in patients with moderate-severe impairment. METHODS: Ten patients with motor impairment at the chronic stage after stroke received a-tDCS, cathodal (c-tDCS) and sham with the target electrode over contralesional motor cortex (M1)...
October 28, 2017: Clinical Neurophysiology: Official Journal of the International Federation of Clinical Neurophysiology
https://www.readbyqxmd.com/read/29145160/larval-development-ratio-test-with-the-calanoid-copepod-acartia-tonsa-as-a-new-bioassay-to-assess-marine-sediment-quality
#5
Isabella Buttino, Valentina Vitiello, Simona Macchia, Alice Scuderi, David Pellegrini
The copepod Acartia tonsa was used as a model species to assess marine sediment quality. Acute and chronic bioassays, such as larval development ratio (LDR) and different end-points were evaluated. As a pelagic species, A. tonsa is mainly exposed to water-soluble toxicants and bioassays are commonly performed in seawater. However, an interaction among A. tonsa eggs and the first larval stages with marine sediments might occur in shallow water environments. Here we tested two different LDR protocols by incubating A...
November 13, 2017: Ecotoxicology and Environmental Safety
https://www.readbyqxmd.com/read/29144915/re-safety-and-effectiveness-of-collagenase-clostridium-histolyticum-in-the-treatment-of-peyronie-s-disease-using-a-new-modified-shortened-protocol
#6
Allen D Seftel
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144897/re-evolution-of-primary-care-referrals-to-urology-impact-of-a-protocol-on-prostate-disease-and-continuing-education
#7
Steven A Kaplan
No abstract text is available yet for this article.
December 2017: Journal of Urology
https://www.readbyqxmd.com/read/29144857/a-review-of-tribal-best-practices-in-substance-abuse-prevention
#8
Allyson Kelley, Morgan Witzel, Bethany Fatupaito
American Indian youth experience higher rates of substance use than non-American Indian youth. Researchers, clinicians, and treatment programs embrace evidence-based practices (EBPs) and practice based evidence (PBE) as a primary method for addressing substance abuse and advancing behavioral health. However, less is known about the use of tribal best practices (TBPs) and how they are implemented in American Indian substance use prevention contexts. OBJECTIVE: The main objective of this systematic review was to determine how TBPs are implemented and shared in the context of tribal substance use prevention...
November 16, 2017: Journal of Ethnicity in Substance Abuse
https://www.readbyqxmd.com/read/29144814/self-blood-glucose-monitoring-underestimates-hyperglycemia-and-hypoglycemia-as-compared-to-continuous-glucose-monitoring-in-type-1-and-type-2-diabetes
#9
Devna Mangrola, Christine Cox, Arianne S Furman, Sridevi Krishnan, Sidika E Karakas
OBJECTIVE: When glucose records from self-blood glucose monitoring (SBGM) do not reflect estimated average glucose from HgBA1, or when patients' clinical symptoms are not explained by their SBGM records, clinical management of diabetes becomes a challenge. Our objective was to determine the magnitude of differences in glucose values reported by SBGM vs. documented by continuous glucose monitoring (CGM). METHODS: The CGM was conducted by a clinical diabetes educator/registered nurse by the clinic protocol, using the Medtronic iPRO2™ system...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144813/diagnosing-and-monitoring-endocrine-dysfunction-diabetes-and-obesity-in-a-cohort-of-adult-survivors-of-childhood-cancer
#10
Victoria Rollins Hudspeth, Stuart Harrison Gold, David Robert Clemmons
OBJECTIVE: 5-year survival for childhood cancer has increased to 80%, resulting in a growing population of adult survivors of childhood cancer (ASOCC). Long-term endocrine dysfunction is as high as 63% when screened in research protocols. The purpose of this study was to evaluate the prevalence of endocrine testing, endocrine dysfunction, diabetes, obesity, and endocrinologist visits outside of a research screening protocol. METHODS: Retrospective chart review was performed for 176 ASOCC who were diagnosed with cancer before age 18, followed at least 10 years, were now at least 18, and had survived to the time of chart review...
November 16, 2017: Endocrine Practice
https://www.readbyqxmd.com/read/29144766/from-ketones-amines-and-carbon-monoxide-to-4-quinolones-palladium-catalyzed-oxidative-carbonylation
#11
Jiwei Wu, Yuchen Zhou, Ting Wu, Yi Zhou, Chien-Wei Chiang, Aiwen Lei
A novel method of palladium-catalyzed oxidative carbonylation of ketones, amines, and carbon monoxide for the synthesis of 4-quinolones has been developed. This protocol provides a straightforward route to construct useful 4-quinolone derivatives from inexpensive chemicals.
November 16, 2017: Organic Letters
https://www.readbyqxmd.com/read/29144742/successful-identification-of-cardiac-troponin-calcium-sensitizers-using-a-combination-of-virtual-screening-and-roc-analysis-of-known-troponin-c-binders
#12
Melanie L Aprahamian, Svetlana B Tikunova, Morgan V Price, Andres F Cuesta, Jonathan P Davis, Steffen Lindert
Calcium-dependent cardiac muscle contraction is regulated by the protein complex troponin. Calcium binds to the N-terminal domain of troponin C (cNTnC) which initiates the process of contraction. Heart failure is a consequence of a disruption of this process. With the prevalence of this condition, a strong need exists to find novel compounds to increase the calcium sensitivity of cNTnC. Desirable are small chemical molecules that bind to the interface between cTnC and the cTnI switch peptide and exhibit calcium sensitizing properties by possibly stabilizing cTnC in an open conformation...
November 16, 2017: Journal of Chemical Information and Modeling
https://www.readbyqxmd.com/read/29144536/isolation-and-whole-genome-sequencing-of-fetal-cells-from-maternal-blood-towards-the-ultimate-non-invasive-prenatal-testing
#13
Fang Chen, Ping Liu, Ying Gu, Zhu Zhu, Amulya Nanisetti, Zhangzhang Lan, Zhiwei Huang, Sophie Jia Liu, Xiongbin Kang, Yuqing Deng, Liqiong Luo, Dan Jiang, Yong Qiu, Jianchang Pan, Jun Xia, Ken Xiong, Chao Liu, Lin Xie, Qianyu Shi, Jing Li, Xiuqing Zhang, Wei Wang, Snezana Drmanac, Hui Jiang, Radoje Drmanac, Xun Xu
OBJECTIVE: To develop a methodology of isolating fetal cells from maternal blood and use deep sequencing demonstrating the promise for more complete and accurate genetic screening compared to other non-invasive prenatal testing (NIPT). METHODS: Here in this study, we developed a double negative selection (DNS) procedure to unbiasedly enrich fetal cells. After validated by short tandem repeat (STR), the isolated CFCs were subjected to deep whole genome sequencing analysis (WGS)...
November 16, 2017: Prenatal Diagnosis
https://www.readbyqxmd.com/read/29144529/driving-dynamic-colloidal-assembly-using-eccentric-self-propelled-colloids
#14
Zhan Ma, Qun-Li Lei, Ran Ni
Designing protocols to dynamically direct the self-assembly of colloidal particles has become an important direction in soft matter physics because of promising applications in the fabrication of dynamic responsive functional materials. Here, using computer simulations, we found that in the mixture of passive colloids and eccentric self-propelled active particles, when the eccentricity and self-propulsion of active particles are high enough, the eccentric active particles can push passive colloids to form a large dense dynamic cluster, and the system undergoes a novel dynamic demixing transition...
November 16, 2017: Soft Matter
https://www.readbyqxmd.com/read/29144523/protein-templated-gold-nanoparticle-synthesis-protein-organization-controlled-gold-sequestration-and-unexpected-reaction-products
#15
Cassidy Hart, Nouf Abuladel, Madeleine Bee, Megan C Kreider, Alexander C CVitan, Moira M Esson, Andrew Farag, Trisha Ibeh, Eleni N Kalivas, Daniel-Mario Larco, Andrew Walker Long, Loukas Lymperopoulos, Zachary Mendel, Nancy Miles, Carly M Zareba, James C Schwabacher, Helen Slucher, Javier Vinals, John M Heddleston, Wenyue Li, Douglas M Fox, Matthew R Hartings
Emerging applications that exploit the properties of nanoparticles for biotechnology require that the nanoparticles be biocompatible or support biological recognition. These types of particles can be produced through syntheses that involve biologically relevant molecules (proteins or natural extracts, for example). Many of the protocols that rely on these molecules are performed without a clear understanding of the mechanism by which the materials are produced. We have investigated a previously described reaction in which gold nanoparticles are produced from the reaction of chloroauric acid and proteins in solution...
November 16, 2017: Dalton Transactions: An International Journal of Inorganic Chemistry
https://www.readbyqxmd.com/read/29144418/nmr-based-identification-of-metabolites-in-polar-and-non-polar-extracts-of-avian-liver
#16
Fariba Fathi, Antonio Brun, Katherine H Rott, Paulo Falco Cobra, Marco Tonelli, Hamid R Eghbalnia, Enrique Caviedes-Vidal, William H Karasov, John L Markley
Metabolites present in liver provide important clues regarding the physiological state of an organism. The aim of this work was to evaluate a protocol for high-throughput NMR-based analysis of polar and non-polar metabolites from a small quantity of liver tissue. We extracted the tissue with a methanol/chloroform/water mixture and isolated the polar metabolites from the methanol/water layer and the non-polar metabolites from the chloroform layer. Following drying, we re-solubilized the fractions for analysis with a 600 MHz NMR spectrometer equipped with a 1...
November 16, 2017: Metabolites
https://www.readbyqxmd.com/read/29144379/a-digital-microfluidics-platform-for-loop-mediated-isothermal-amplification-detection
#17
Beatriz Jorge Coelho, Bruno Veigas, Hugo Águas, Elvira Fortunato, Rodrigo Martins, Pedro Viana Baptista, Rui Igreja
Digital microfluidics (DMF) arises as the next step in the fast-evolving field of operation platforms for molecular diagnostics. Moreover, isothermal schemes, such as loop-mediated isothermal amplification (LAMP), allow for further simplification of amplification protocols. Integrating DMF with LAMP will be at the core of a new generation of detection devices for effective molecular diagnostics at point-of-care (POC), providing simple, fast, and automated nucleic acid amplification with exceptional integration capabilities...
November 16, 2017: Sensors
https://www.readbyqxmd.com/read/29144297/effect-of-reagents-used-during-detection-and-quantification-of-ascaris-suum-in-environmental-samples-on-egg-viability
#18
Isaac Dennis Amoah, Poovendhree Reddy, Thor Axel Stenström
Soil-transmitted helminths (STHs) are a major health concern globally. Infection is mostly through contact with contaminated water, food or soil. Therefore to break the cycle of viable transmission STH eggs must be quantitatively detected in the environment. The effect of different reagents on the viability of Ascaris suum eggs during laboratory detection and quantification was assessed and different incubation solutions compared. Sulphuric acid gave a slightly higher recovery percentage of viable eggs (91...
November 2017: Water Science and Technology: a Journal of the International Association on Water Pollution Research
https://www.readbyqxmd.com/read/29144161/use-of-patient-outcome-endpoints-to-identify-the-best-functional-ct-imaging-parameters-in-metastatic-renal-cell-carcinoma-patients
#19
Jill Rachel Mains, Frede Donskov, Erik Morre Petersen, Hans Henrik Torp Madsen, Jesper Thygesen, Kennet Thorup, Finn Rasmussen
OBJECTIVE: To use the patient outcome endpoints overall survival and progression-free survival to evaluate functional parameters derived from dynamic contrast-enhanced computed tomography (DCE-CT). METHODS: 69 patients with metastatic renal cell carcinoma (mRCC) had DCE-CT scans at baseline and after 5 and 10 weeks of treatment. Blood volume, blood flow and standardized perfusion values were calculated using deconvolution (BVdeconv, BFdeconv and SPVdeconv), blood flow and standardized perfusion values using maximum slope (BFmax and SPVmax), and blood volume and permeability surface area product using the Patlak model (BVpatlak and PS)...
November 16, 2017: British Journal of Radiology
https://www.readbyqxmd.com/read/29144103/effects-of-home-based-superimposed-neuromuscular-electrical-stimulation-in-severe-chronic-obstructive-pulmonary-disease-patients-a-randomized-controlled-clinical-trial
#20
Marie C Valenza, Irene Torres-Sánchez, Laura López-López, Irene Cabrera-Martos, Araceli Ortiz-Rubio, Gerald Valenza-Demet
BACKGROUND: COPD patients experience a sustained deterioration of several capacities. Those with severe COPD undergo a considerable decline in their physical and functional capacities, but pulmonary rehabilitation (PR) is used to reduce the weakness of such patients. To date, neuromuscular electrical stimulation (NMES) has been used in acute COPD patients but NMES superimposed onto voluntary muscular contraction has not been tested in COPD patients. AIM: The aim of this study was to evaluate the effects of superimposed NMES on the cardiorespiratory performance and functionality of severe COPD patients undergoing a home-based rehabilitation program...
November 16, 2017: European Journal of Physical and Rehabilitation Medicine
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