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https://www.readbyqxmd.com/read/28749525/perceived-barriers-to-implementing-screening-and-brief-intervention-for-alcohol-consumption-by-adolescents-in-hospital-emergency-department-in-spain
#1
María Falcón, Javier Navarro-Zaragoza, Rosa María García-Rodríguez, Daniel Nova-López, María Dulce González-Navarro, María Mercadal, Oscar García-Algar, Aurelio Luna Ruiz-Cabello
BACKGROUND: Screening for alcohol consumption in adolescents is widely justified in the health care field because of the particular vulnerability of this population, which starts drinking alcohol at a very early age and frequently consumes high levels of the same. Hospital emergency departments (ED) could be a good venue to manage early detection and carry out brief intervention (BI) programmes. OBJECTIVES: The aim of this study was to identify perceived barriers for medical staff of three hospitals in Spain to successfully implement a protocol for alcohol detection and BI for minors in the ED...
July 14, 2017: Adicciones
https://www.readbyqxmd.com/read/28749522/palladium-catalyzed-decarboxylative-decarbonylative-and-dehydrogenative-c-sp-2-h-acylation-at-room-temperature
#2
Asik Hossian, Manash Kumar Manna, Kartic Manna, Ranjan Jana
Over the past few decades, an impressive array of C-H activation methodology has been developed for organic synthesis. However, due to the inherent inertness of the C-H bonds (e.g. ∼110 kcal mol(-1) for the cleavage of C(aryl)-H bonds) harsh reaction conditions have been realized to overcome high energetic transition states resulting in a limited substrate scope and functional group tolerance. Therefore, the development of mild C-H functionalization protocols is in high demand to exploit the full potential of the C-H activation strategy in the synthesis of a complex molecular framework...
July 27, 2017: Organic & Biomolecular Chemistry
https://www.readbyqxmd.com/read/28749321/design-and-implementation-of-an-affordable-public-sector-electronic-medical-record-in-rural-nepal
#3
Anant Raut, Chase Yarbrough, Vivek Singh, Bikash Gauchan, David Citrin, Varun Verma, Jessica Hawley, Dan Schwarz, Alex Harsha Bangura, Biplav Shrestha, Ryan Schwarz, Mukesh Adhikari, Duncan Maru
INTRODUCTION: Globally, electronic medical records are central to the infrastructure of modern healthcare systems. Yet the vast majority of electronic medical records have been designed for resource-rich environments and are not feasible in settings of poverty. Here we describe the design and implementation of an electronic medical record at a public sector district hospital in rural Nepal, and its subsequent expansion to an additional public sector facility.DevelopmentThe electronic medical record was designed to solve for the following elements of public sector healthcare delivery: 1) integration of the systems across inpatient, surgical, outpatient, emergency, laboratory, radiology, and pharmacy sites of care; 2) effective data extraction for impact evaluation and government regulation; 3) optimization for longitudinal care provision and patient tracking; and 4) effectiveness for quality improvement initiatives...
June 23, 2017: Journal of Innovation in Health Informatics
https://www.readbyqxmd.com/read/28749305/the-pharmacokinetics-of-topical-itraconazole-in-panamanian-golden-frogs-atelopus-zeteki
#4
Amy Rifkin, Marike Visser, Kevin Barrett, Dawn Boothe, Ellen Bronson
Chytridiomycosis is caused by the fungus Batrachochytrium dendrobatidis and is one of the primary causes of the global decline in amphibian populations and specifically of the Panamanian golden frog ( Atelopus zeteki ). Itraconazole has been demonstrated to be an effective treatment for chytridiomycosis by inhibiting cytochrome P450, a major enzyme important for the structure of B. dendrobatidis zoospores' plasma membranes. However, anecdotal reports of toxicity in this and other amphibian species have been reported at the 0...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749290/granulomatous-encephalomyelitis-in-a-false-gharial-tomistoma-schlegelii-associated-with-a-novel-chlamydia-species
#5
Marjorie Bercier, Darryl J Heard, Alexandra M Goe, Ember Epperson, Jeffrey R Abbott, April L Childress, James F X Wellehan
A 5-yr-old, captive, hatched, female false gharial (Tomistoma schlegelii) presented with a 1-mo history of cervical spinal curvature. Antemortem diagnostics, including blood work, electromyography, muscle biopsies, and advanced imaging tests, were either within reference ranges or did not identify any specific etiology. Necropsy revealed extensive, marked, chronic granulomatous encephalomyelitis along with neuronal necrosis, rarefaction, gliosis, and astrocytosis of the white and gray matter of the cerebrum, cerebellum, brainstem, and spinal cord...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749272/ketamine-medetomidine-and-ketamine-medetomidine-midazolam-anesthesia-in-captive-cheetahs-acinonyx-jubatus-comparison-of-blood-pressure-and-kidney-blood-flow
#6
Julia Stagegaard, Arne Hørlyck, Helle B Hydeskov, Mads F Bertelsen
Six clinically healthy captive cheetahs ( Acinonyx jubatus ) were anesthetized twice using two different drug combinations to investigate if blood pressure and kidney blood flow are affected by medetomidine dosage. Protocol KM (2.0 mg/kg ketamine and 0.05 mg/kg medetomidine) was compared with protocol KMM (2.0 mg/kg ketamine, 0.02 mg/kg medetomidine, and 0.1 mg/kg midazolam). Heart rate (HR), respiratory rate (RR), body temperature, end-tidal carbon dioxide pressure (ETCO2), and anesthetic depth were monitored every 10 min...
June 2017: Journal of Zoo and Wildlife Medicine: Official Publication of the American Association of Zoo Veterinarians
https://www.readbyqxmd.com/read/28749204/revision-of-a-furosemide-loading-vestibular-evoked-myogenic-potential-protocol-for-detecting-endolymphatic-hydrops
#7
Toru Seo, Ko Shiraishi, Takaaki Kobayashi, Kitano Mutsukazu, Takeshi Fujita, Kazuya Saito, Katsumi Doi
OBJECTIVE: The presence of endolymphatic hydrops can be suggested by improving the amplitude of vestibular-evoked myogenic potential (VEMP) after furosemide administration (furosemide loading VEMP [FVEMP]). The authors aimed to determine a stimulation frequency and judgment criteria to ascertain whether a revised FVEMP protocol can be applied to clinical settings. METHODS: The study included 25 individuals with unilateral Meniere's disease (MD) and 11 normal healthy volunteers...
July 27, 2017: Acta Oto-laryngologica
https://www.readbyqxmd.com/read/28749083/evidence-of-bone-marrow-downregulation-in-brain-dead-rats
#8
Laura Menegat, Rafael Simas, Julia M Caliman, Fernando L Zanoni, Jacqueline F Jacysyn, Luiz Fernando F da Silva, Primavera Borelli, Luiz Felipe P Moreira, Paulina Sannomiya
Experimental findings support the evidence of a persistent leucopenia triggered by brain death (BD). This study aimed to investigate leucocyte behaviour in bone marrow and blood after BD in rats. BD was induced using intracranial balloon catheter inflation. Sham-operated (SH) rats were trepanned only. Thereafter bone marrow cells were harvested every six hours from the femoral cavity and used for total and differential counts. They were analysed further by flow cytometry to characterize lymphocyte subsets, granulocyte adhesion molecules expression and apoptosis/necrosis [annexin V/propidium iodide (PI) protocol]...
July 27, 2017: International Journal of Experimental Pathology
https://www.readbyqxmd.com/read/28749062/the-art-of-the-cover
#9
Nora Porter
Often, it's difficult to match up our cover artwork with the subjects of our lead articles and special reports. Of necessity, we sometimes turn to pure abstraction. How else to illustrate technical policy articles on subjects such as changing research protocols or informed consent, or abstract ideas like congruence, duality, imbalance, causality? At such times, we have to be pretty creative, and my search for cover art can be long and challenging. In the end, we hope that the reader will make the connection between cover and content...
July 2017: Hastings Center Report
https://www.readbyqxmd.com/read/28749045/factors-related-to-recurrence-of-idiopathic-granulomatous-mastitis-what-do-we-learn-from-a-multicentre-study
#10
Erdal Uysal, Atilla Soran, Efe Sezgin
BACKGROUND: Idiopathic granulomatous mastitis (IGM) is a rare chronic inflammatory disease of the breast with unknown aetiology. Its treatment is controversial and the recurrence rate is high. The objectives of this study were to examine the demographic, sociocultural and clinical characteristics observed among a large cohort of IGM patients from Turkey and to identify factors related to the recurrence of IGM. METHODS: The study was designed as a multicentre retrospective study including 22 breast centres in Turkey...
July 27, 2017: ANZ Journal of Surgery
https://www.readbyqxmd.com/read/28749037/transfusion-for-sickle-cell-disease-in-pregnancy-a-single-centre-survey
#11
J Sharif, L Byrd, K Stevenson, J Raddats, E Morsman, K Ryan
INTRODUCTION: Sickle cell disease in pregnancy carries a high risk of maternal and fetal adverse outcomes. The use of prophylactic transfusions to reduce the risk of sickle complications is controversial. Current UK standards do not recommend the routine use of transfusion for sickle pregnancy. We examined transfusion episodes during sickle pregnancies in a single centre over an 11-year period. METHODS: We conducted a retrospective observational study of all pregnancies in patients with sickle cell disease who attended the joint obstetric/haematology clinic over an 11-year period...
July 27, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28748994/-intravenous-thrombolysis-for-acute-ischemic-stroke-a-four-years%C3%A2-experience-in-a-chilean-public-hospital
#12
Álvaro Soto V, Gladys Morales I, Marcela Grandjean B, Débora Pollak W, Carolina Del Castillo C, Pía García F, Alexis Von Johnn A, Alfonso Riquelme G
BACKGROUND: Intravenous thrombolysis (IVT) with alteplase (tissue plasminogen activator) is the standard pharmacological treatment in acute ischemic stroke (AIS), reducing disability in patients. AIM: To report the results a thrombolysis protocol during four years in a regional public hospital. MATERIAL AND METHODS: Data from 106 consecutive patients aged 68 ± 13 years (57% men) who were treated with IVT, from May 2012 until April 2016, was analyzed...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748993/-sedentary-lifestyle-is-associated-with-metabolic-and-cardiovascular-risk-factors-independent-of-physical-activity
#13
Ana María Leiva, María Adela Martínez, Carlos Cristi-Montero, Carlos Salas, Rodrigo Ramírez-Campillo, Ximena Díaz Martínez, Nicolás Aguilar-Farías, Carlos Celis-Morales
BACKGROUND: Sedentary behavior is a main risk factor for cardiovascular disease and mortality. AIM: To investigate the association between sedentary behavior and metabolic and cardiovascular risk factors. MATERIAL AND METHODS: We assessed 322 participants aged between 18 to 65 years. Physical activity and sedentary behavior were measured with accelerometers (Actigraph®). Body mass index (BMI), waist circumference, percentage of body fat, diet and blood markers (glucose, lipid profile, insulin and HOMA-IR) were measured with standardized protocols...
April 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28748983/design-planning-and-management-of-the-hospital-custody-unit-at-hospital-universitario-fundaci%C3%A3-n-alcorc%C3%A3-n
#14
C de la Fuente-Martín, B de la Fuente Martín, E Grifol-Clar
OBJECTIVE: The design and management of a Hospital Custody Unit at Hospital Universitario Fundación Alcorcón, to focus the aim of this study on specialized medical care for extra-penitentiary patients who have suffered from a disease. We are building a new space to facilitate their daily lives at hospital and we want to offer a double function to the patients that consists of a custody space and a health rehabilitation space. MATERIAL AND METHODS: We carried out a scientific literature search on the international and national databases, about Hospital Custody Units or Restricted Access Units...
December 2017: Revista Española de Sanidad Penitenciaria
https://www.readbyqxmd.com/read/28748969/discovering-intratumor-heterogeneity-the-next-frontier-for-pathologists
#15
J I López, G De Petris
Discovering intratumor heterogeneity is a crucial issue in modern oncologic medicine. Highly sophisticated technology such as high-throughput DNA sequencing has demonstrated the real dimension of the problem. The overwhelming majority of malignant tumors show high levels of intratumor heterogeneity when thoroughly studied. Intratumor heterogeneity develops both in temporal and spatial domains and its distribution is not deterministic making each case truly unique and unrepeatable. Pathologists are main actors in intratumor heterogeneity detection since they are the medical specialists who sample the tumors...
June 2017: Pathologica
https://www.readbyqxmd.com/read/28748771/acute-care-referral-systems-in-liberia-transfer-and-referral-capabilities-in-a-low-income-country
#16
Jimin Kim, Maria Barreix, Christine Babcock, Corey B Bills
Introduction Following two decades of armed conflict in Liberia, over 95% of health care facilities were partially or completely destroyed. Although the Liberian health system has undergone significant rehabilitation, one particular weakness is the lack of organized systems for referral and prehospital care. Acute care referral systems are a critical component of effective health care delivery and have led to improved quality of care and patient outcomes. Problem This study aimed to characterize the referral and transfer systems in the largest county of Liberia...
July 27, 2017: Prehospital and Disaster Medicine
https://www.readbyqxmd.com/read/28748648/accurate-template-based-modelling-in-casp12-using-the-intfold4-ts-modfold6-and-refold-methods
#17
Liam J McGuffin, Ahmad N Shuid, Robert Kempster, Ali H A Maghrabi, John O Nealon, Bajuna R Salehe, Jennifer D Atkins, Daniel B Roche
Our aim in CASP12 was to improve our Template Based Modelling (TBM) methods through better model selection, accuracy self-estimate (ASE) scores and refinement. To meet these aims we developed two new automated methods, which we used to score, rank and improve upon the provided server models. Firstly, the ModFOLD6_rank method, for improved global Quality Assessment (QA), model ranking and the detection of local errors. Secondly, the ReFOLD method for fixing errors through iterative QA guided refinement. For our automated predictions we developed the IntFOLD4-TS protocol, which integrates the ModFOLD6_rank method for scoring the multiple-template models that were generated using a number of alternative sequence-structure alignments...
July 27, 2017: Proteins
https://www.readbyqxmd.com/read/28748548/highly-diastereo-and-enantioselective-synthesis-of-tetrahydro-5h-indolo-2-3-b-quinolines-via-copper-catalyzed-propargylic-dearomatization-of-indoles
#18
Shuli You, Wen Shao
The first copper-catalyzed intermolecular asymmetric propargylic dearomatization/annulation cascade sequence of indoles via copper-allenylidene amphiphilic intermediate has been realized. This protocol provides a direct asymmetric synthetic method for the preparation of tetrahydro-5H-indolo[2,3-b]quinolones, the core structure of indole alkaloids communesins A-H and perophoramidine. This method features excellent yields, high diastereoselectivity (up to >19/1 dr) and enantioselectivity (up to 94% ee), mild conditions and wide substrate scope...
July 26, 2017: Chemistry: a European Journal
https://www.readbyqxmd.com/read/28748481/public-health-relevance-of-drug-nutrition-interactions
#19
Szabolcs Péter, Gerjan Navis, Martin H de Borst, Clemens von Schacky, Anne Claire B van Orten-Luiten, Alexandra Zhernakova, Renger F Witkamp, André Janse, Peter Weber, Stephan J L Bakker, Manfred Eggersdorfer
The public health relevance of drug-nutrition interactions is currently highly undervalued and overlooked. This is particularly the case for elderly persons where multi-morbidity and consequently polypharmacy is very common. Vitamins and other micronutrients have central functions in metabolism, and their interactions with drugs may result in clinically relevant physiological impairments but possibly also in positive effects. On 12 April 2016, the University Medical Center Groningen (The Netherlands), as part of its Healthy Ageing program, organized a workshop on the public health relevance of drug-nutrient interactions...
July 26, 2017: European Journal of Nutrition
https://www.readbyqxmd.com/read/28748477/chromogenic-in-situ-hybridization-methods-for-microrna-biomarker-monitoring-of-drug-safety-and-efficacy
#20
Barbara R Gould, Tina Damgaard, Boye Schnack Nielsen
Disease research and treatment development have turned to the impact and utility of microRNA. The dynamic and highly specific expression of these molecular regulators can be used to predict and monitor disease progression as well as therapeutic treatment efficacy and safety, thus aiding decisions in patient care. In situ hybridization (ISH) of biopsy material has become a routine clinical pathology procedure for monitoring gene structure, expression, and sample characterization. For ribonucleic acid (RNA), determining cell source and level of expression of these biomarkers gives insight into the cellular function and physiopathology...
2017: Methods in Molecular Biology
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