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JOURNAL ARTICLE
Steve E Kalloger, Amanda Watson, Shawn Sajkowski, Natacha Bolaños, Lorna Warwick
No abstract text is available yet for this article.
April 5, 2024: Journal of the National Comprehensive Cancer Network: JNCCN
#2
JOURNAL ARTICLE
Kyung Chan Park, Nicholas T Crump, Niamh Louwman, Steve Krywawych, Yuen Jian Cheong, Iolanda Vendrell, Eleanor K Gill, Mala Gunadasa-Rohling, Kerrie L Ford, David Hauton, Marjorie Fournier, Elisabete Pires, Lydia Watson, Gerald Roseman, James Holder, Andreas Koschinski, Ricardo Carnicer, M Kate Curtis, Manuela Zaccolo, Alzbeta Hulikova, Roman Fischer, Holger B Kramer, James S O McCullagh, Sophie Trefely, Thomas A Milne, Pawel Swietach
Propiogenic substrates and gut bacteria produce propionate, a post-translational protein modifier. In this study, we used a mouse model of propionic acidaemia (PA) to study how disturbances to propionate metabolism result in histone modifications and changes to gene expression that affect cardiac function. Plasma propionate surrogates were raised in PA mice, but female hearts manifested more profound changes in acyl-CoAs, histone propionylation and acetylation, and transcription. These resulted in moderate diastolic dysfunction with raised diastolic Ca2+ , expanded end-systolic ventricular volume and reduced stroke volume...
December 2023: Nat Cardiovasc Res
#3
JOURNAL ARTICLE
Iakov Bolnykh, Joanne M Patterson, Sam Harding, Laura-Jayne Watson, Liya Lu, Katrina Hurley, Steve J Thomas, Linda Sharp
PURPOSE: Reports suggest pain is common in head and neck cancer (HNC). However, past studies are limited by small sample sizes and design and measurement heterogeneity. Using data from the Head and Neck 5000 longitudinal cohort, we investigated pain over a year post-diagnosis. We assessed: temporal trends; compared pain across HNC treatments, stages, sites and by HPV status; and identified subgroups of patients at increased risk of pain. METHODS: Sociodemographic and clinical data and patient-reported pain (measured by EORTC QLQ-C30 and QLQ-H&N35) were collected at baseline (pre-treatment), 4- and 12- months...
February 29, 2024: Journal of Cancer Survivorship: Research and Practice
#4
JOURNAL ARTICLE
Peter Y F Zeng, Stephenie D Prokopec, Stephen Y Lai, Nicole Pinto, Michelle A Chan-Seng-Yue, Roderick Clifton-Bligh, Michelle D Williams, Christopher J Howlett, Paul Plantinga, Matthew J Cecchini, Alfred K Lam, Iram Siddiqui, Jianxin Wang, Ren X Sun, John D Watson, Reju Korah, Tobias Carling, Nishant Agrawal, Nicole Cipriani, Douglas Ball, Barry Nelkin, Lisa M Rooper, Justin A Bishop, Cathie Garnis, Ken Berean, Norman G Nicolson, Paul Weinberger, Ying C Henderson, Christopher M Lalansingh, Mao Tian, Takafumi N Yamaguchi, Julie Livingstone, Adriana Salcedo, Krupal Patel, Frederick Vizeacoumar, Alessandro Datti, Liu Xi, Yuri E Nikiforov, Robert Smallridge, John A Copland, Laura A Marlow, Martin D Hyrcza, Leigh Delbridge, Stan Sidhu, Mark Sywak, Bruce Robinson, Kevin Fung, Farhad Ghasemi, Keith Kwan, S Danielle MacNeil, Adrian Mendez, David A Palma, Mohammed I Khan, Mushfiq Shaikh, Kara M Ruicci, Bret Wehrli, Eric Winquist, John Yoo, Joe S Mymryk, James W Rocco, David Wheeler, Steve Scherer, Thomas J Giordano, John W Barrett, William C Faquin, Anthony J Gill, Gary Clayman, Paul C Boutros, Anthony C Nichols
Anaplastic thyroid carcinoma is arguably the most lethal human malignancy. It often co-occurs with differentiated thyroid cancers, yet the molecular origins of its aggressivity are unknown. We sequenced tumor DNA from 329 regions of thyroid cancer, including 213 from patients with primary anaplastic thyroid carcinomas. We also whole genome sequenced 9 patients using multi-region sequencing of both differentiated and anaplastic thyroid cancer components. Using these data, we demonstrate thatanaplastic thyroid carcinomas have a higher burden of mutations than other thyroid cancers, with distinct mutational signatures and molecular subtypes...
February 26, 2024: Cell Reports
#5
JOURNAL ARTICLE
Xueqing Wang, Alexandre Slater, Sarah C Lee, Neale Harrison, Naomi L Pollock, Saskia E Bakker, Stefano Navarro, Bernhard Nieswandt, Tim R Dafforn, Ángel García, Steve P Watson, Michael G Tomlinson
The collagen/fibrin(ogen) receptor, glycoprotein VI (GPVI), is a platelet activating receptor and a promising anti-thrombotic drug target. However, while agonist-induced GPVI clustering on platelet membranes has been shown to be essential for its activation, it is unknown if GPVI dimerisation represents a unique conformation for ligand binding. Current GPVI structures all contain only the two immunoglobulin superfamily (IgSF) domains in the GPVI extracellular region, so lacking the mucin-like stalk, transmembrane, cytoplasmic tail of GPVI and its associated Fc receptor γ (FcRγ) homodimer signalling chain, and provide contradictory insights into the mechanisms of GPVI dimerisation...
February 21, 2024: Archives of Biochemistry and Biophysics
#6
JOURNAL ARTICLE
Suvi T Vaara, Ary Serpa Neto, Rinaldo Bellomo, Neill K J Adhikari, Didier Dreyfuss, Martin Gallagher, Stephane Gaudry, Eric Hoste, Michael Joannidis, Ville Pettilä, Amanda Y Wang, Kianoush Kashani, Ron Wald, Sean M Bagshaw, Marlies Ostermann
OBJECTIVES: Among patients with severe acute kidney injury (AKI) admitted to the ICU in high-income countries, regional practice variations for fluid balance (FB) management, timing, and choice of renal replacement therapy (RRT) modality may be significant. DESIGN: Secondary post hoc analysis of the STandard vs. Accelerated initiation of Renal Replacement Therapy in Acute Kidney Injury (STARRT-AKI) trial (ClinicalTrials.gov number NCT02568722). SETTING: One hundred-fifty-three ICUs in 13 countries...
February 2024: Critical care explorations
#7
JOURNAL ARTICLE
Tiziana Lanciano, Federica Alfeo, Antonietta Curci, Claudia Marin, Angela Maria D'Uggento, Diletta Decarolis, Sezin Öner, Kristine Anthony, Krystian Barzykowski, Miguel Bascón, Alec Benavides, Anne Cabildo, Manuel Luis de la Mata-Benítez, İrem Ergen, Katarzyna Filip, Alena Gofman, Steve M J Janssen, Zhao Kai-Bin, Ioanna Markostamou, Jose Antonio Matías-García, Veronika Nourkova, Sebastian Oleksiak, Andrés Santamaría, Karl Szpunar, Andrea Taylor, Lynn Ann Watson, Jin Zheng
Flashbulb memories (FBMs) refer to vivid and long-lasting autobiographical memories for the circumstances in which people learned of a shocking and consequential public event. A cross-national study across eleven countries aimed to investigate FBM formation following the first COVID-19 case news in each country and test the effect of pandemic-related variables on FBM. Participants had detailed memories of the date and others present when they heard the news, and had partially detailed memories of the place, activity, and news source...
February 5, 2024: Memory
#8
JOURNAL ARTICLE
Jeffrey Sioufi, Brandon Hall, Ryan Antel, Sarah Moussa, Mathushan Subasri, Mustafa Fakih, Nehal Islam, Reggie C Hamdy, Sonaina Chopra, Jason M Harley, Amy Keuhl, Ereny Bassilious, Jonathan Sherbino, Elif Bilgic, Mohamed S Bondok, Mostafa Bondok, Liana Martel, Christine Law, Nancy Posel, David Fleiszer, Anser Daud, Tyler Hauer, Noah Carr-Pries, Kalter Hali, Jesse Wolfstadt, Peter Ferguson, Arashk Ghasroddashti, Fatimah Sorefan-Mangou, Rosephine Del Fernandes, Erin Williams, Ken Choi, Boris Zevin, Ethan D Patterson, Sawmmiya Kirupaharan, Steve Mann, Andrea Winthrop, Boris Zevin, Mostafa Bondok, Nibras Ghanmi, Cole Etherington, Youssef Saddiki, Isabelle Lefebvre, Pauline Berthelot, Pierre-Marc Dion, Benjamin Raymond, Jeanne Seguin, Pooyan Sekhavati, Sindeed Islam, Sylvain Boet, Trisha Tee, Puja Pachchigar, Bilal Tarabay, Recai Yilmaz, Nour Abou Hamdan, Chinyelum Agu, Abdulrahman Almansouri, Jason Harley, Rolando Del Maestro, Mostafa Bondok, Mohamed S Bondok, Anne Xuan-Lan Nguyen, Christine Law, Nawaaz Nathoo, Nupura Bakshi, Nina Ahuja, Karim F Damji, Keerat Grewal, Sayed Azher, Matthew Moreno, Reinhard Pekrun, Jeffrey Wiseman, Gerald M Fried, Susanne Lajoie, Ryan Brydges, Allyson Hadwin, Ning-Zi Sun, Elene Khalil, Jason M Harley, Emily Lan-Vy Nguyen, Prachikumari Patel, Hala Muaddi, Nadia Rukavina, Roxana Bucur, Chaya Shwaartz, Nehal Islam, Sarah Moussa, Mathushan Subasri, Moustafa Fakih, Reggie Charles Hamdy, Evan Wong, Aradhana Tewari, Ryan Brydges, Marisa Louridas, Shilpa Balaji, Prachi Patel, Hala Muaddi, Karolina Gaebe, Carla Luzzi, Aileigh Kay, Nadia Rukavina, Markus Selzner, Trevor Reichman, Chaya Shwaartz, Shilpa Balaji, Hala Muaddi, Ali Shahabinezhad, Prachi Patel, Nadia Rukavina, Trevor Reichman, Shiva Jayaraman, Chaya Shwaartz, Joseph Nashed, Luca Ramelli, Owen Kolasky, Tiffany Dickenson, Mike Dullege, Annie Kang, Andrea Winthrop, Steve Mann, Davy Lau, Erika Henkelman, John Jacob, Isabella Watson, Faizal Haji, Charlotte C McEwen, Iqbal Jaffer, Matthew Sibbald, Victoria Blouin, Florence Bénard, Florence Pelletier, Sandy Abdo, Léamarie Meloche-Dumas, Bill Kapralos, Adam Dubrowski, Erica Patocskai, Puja Pachchigar, Chinyelum Agu, Recai Yilmaz, Trisha Tee, Rolando Del Maestro, Ifeoluwa Adedipe, Carolyn Stephens, Merry Ghebretatios, Simon Laplante, Prachi Patel, Shilpa Balaji, Hala Muaddi, Nadia Rukavina, Chaya Shwaartz, Maren Brodovsky, Carolyn Lai, Abdollah Behzadi, Geoffrey Blair, Abdulrahman Almansouri, Nour Abou Hamdan, Recai Yilmaz, Trisha Tee, Puja Pachchigar, Mohammadreza Eskandari, Chinyelum Agu, Bianca Giglio, Neevya Balasubramaniam, Josh Bierbrier, D Louis Collins, Houssem-Eddine Gueziri, Rolando F Del Maestro, Ella Koonar, Fatemeh Ramazani, Robert Hart, Jessica Henley, Sam Roberts, Shamir Chandarana, Wayne Matthews, Christiaan Schrag, Jennifer Matthews, David Mackenzie, Court Cutting, Justin Lui, Éolie Delisle, Tomas Cordoba, Carlos Cordoba, Bianca Giglio, Adrien Lacroix, Julianne Cairns, Ahmad Alsayegh, Mohamed Alhantoobi, Neevya Balasubramaniam, Widad Safih, Meriem Hamel, Rolando Del Maestro, Gizelle Francis, Alexander Moise, Youssef Omar, Kalpesh Hathi, Dorsa Mavedatnia, Elysia Grose, Timothy Philips, Clément Schneider, Denis Corbin, François Lesage, Michel Pellerin, Walid Ben-Ali, Zakaria Tamani, Maxine Joly-Chevrier, Florence Bénard, Léamarie Meloche-Dumas, Laurence Laflamme, Kerianne Boulva, Rami Younan, Adam Dubrowski, Erica Patocskai, Giancarlo Sticca, Joseph Petruccelli, Dominique Dorion, Yasmin Osman, Florence Bénard, Merieme Habti, Léamarie Meloche-Dumas, Xaviery Duranleau, Kerianne Boulva, Ahmad Kaviani, Rami Younan, Adam Dubrowski, Kiara Vessella, Erica Patocskai, Rahim Valji, Simon Turner, Tobi Lam, Melanie Hammond Mobilio, Jacob Hirsh, Dean Lising, Tulin Cil, Edyta Marcon, Carol-Anne Moulton, Alexandra D'Souza, Thomas Milazzo, Shaishav Datta, Chantal Valiquette, Emma Avery, Sophocles Voineskos, Melinda Musgrave, Kyle Wanzel, Jillian Schneidman, Neil Armstrong, George Gerardis, Jennifer Silver, Milène A Azzam, Rachel Fisher, Ilana Banks, Meredith Young, Lily Hp Nguyen, Megan Skakum, B J Hancock, Suyin Lum Min, Fouad Youssef, Richard Keijzer, Melanie Morris, Anna Shawyer, Giuseppe Retrosi
No abstract text is available yet for this article.
2023: Canadian Journal of Surgery. Journal Canadien de Chirurgie
#9
Nadeem Qureshi, Bethan Woods, Rita Neves de Faria, Pedro Saramago Goncalves, Edward Cox, Jo Leonardi Bee, Laura Condon, Stephen Weng, Ralph K Akyea, Barbara Iyen, Paul Roderick, Steve E Humphries, William Rowlands, Melanie Watson, Kate Haralambos, Ryan Kenny, Dev Datta, Zosia Miedzybrodzka, Christopher Byrne, Joe Kai
BACKGROUND: Cascade testing the relatives of people with familial hypercholesterolaemia is an efficient approach to identifying familial hypercholesterolaemia. The cascade-testing protocol starts with identifying an index patient with familial hypercholesterolaemia, followed by one of three approaches to contact other relatives: indirect approach, whereby index patients contact their relatives; direct approach, whereby the specialist contacts the relatives; or a combination of both direct and indirect approaches...
October 2023: Health Technology Assessment: HTA
#10
JOURNAL ARTICLE
Steve Kaplan, Ronald P Kaufman, Thomas Mueller, Dean Elterman, Bilal Chughtai, Daniel Rukstalis, Henry Woo, Claus Roehrborn
BACKGROUND: Up to 50% of men over 50 and 80% over 80 are affected by BPH. Shared decision-making regarding BPH treatment options can benefit from an improved understanding of relative risks and benefits for various treatments. METHODS: Data for this longitudinal retrospective population-based cohort study were obtained from a random sample of US Medicare and commercial claims (IBM Watson MarketScan) and restricted to men undergoing BPH surgery (TURP, PVP, PUL, WVTT) from 2015 to 2021 across all sites of service...
October 26, 2023: Prostate Cancer and Prostatic Diseases
#11
JOURNAL ARTICLE
Andrew Levan, Benjamin P Gompertz, Om Sharan Salafia, Mattia Bulla, Eric Burns, Kenta Hotokezaka, Luca Izzo, Gavin P Lamb, Daniele B Malesani, Samantha R Oates, Maria Edvige Ravasio, Alicia Rouco Escorial, Benjamin Schneider, Nikhil Sarin, Steve Schulze, Nial R Tanvir, Kendall Ackley, Gemma Anderson, Gabriel B Brammer, Lise Christensen, Vikram S Dhillon, Phil A Evans, Michael Fausnaugh, Wen-Fai Fong, Andrew S Fruchter, Chris Fryer, Johan P U Fynbo, Nicola Gaspari, Kasper E Heintz, Jens Hjorth, Jamie A Kennea, Mark R Kennedy, Tanmoy Laskar, Giorgos Leloudas, Ilya Mandel, Antonio Martin-Carrillo, Brian D Metzger, Matt Nicholl, Anya Nugent, Jesse T Palmerio, Giovanna Pugliese, Jillian Rastinejad, Lauren Rhodes, Andrea Rossi, Andrea Saccardi, Stephen J Smartt, Heloise F Stevance, Aaron Tohuvavohu, Alexander van der Horst, Susanna D Vergani, Darach Watson, Thomas Barclay, Kornpob Bhirombhakdi, Elmé Breedt, Alice A Breeveld, Alexander J Brown, Sergio Campana, Ashley A Chrimes, Paolo D'Avanzo, Valerio D'Elia, Massimiliano De Pasquale, Martin J Dyer, Duncan K Galloway, James A Garbutt, Matthew J Green, Dieter H Hartmann, Páll Jakobsson, Paul Kerry, Chryssa Kouveliotou, Danial Langeroodi, Emeric Le Floc'h, James K Leung, Stuart P Littlefair, James Munday, Paul O'Brien, Steven G Parsons, Ingrid Pelisoli, David I Sahman, Ruben Salvaterra, Boris Sbarufatti, Danny Steeghs, Gianpiero Tagliaferri, Christina C Thöne, Antonio de Ugarte Postigo, David Alexander Kann
The mergers of binary compact objects such as neutron stars and black holes are of central interest to several areas of astrophysics, including as the progenitors of gamma-ray bursts (GRBs)1 , sources of high-frequency gravitational waves (GW)2 and likely production sites for heavy element nucleosynthesis via rapid neutron capture (the r-process)3 . Here we present observations of the exceptionally bright gamma-ray burst GRB 230307A. We show that GRB 230307A belongs to the class of long-duration gamma-ray bursts associated with compact object mergers4-6 , and contains a kilonova similar to AT2017gfo, associated with the gravitational-wave merger GW1708177-12 ...
October 25, 2023: Nature
#12
JOURNAL ARTICLE
Steve Leung, Erica McDonald, Amy Watson, Quynh Doan, Neil Desai
PURPOSE: Pediatric emergency departments are overcrowded, in part due to many non-emergent visits. We aimed to assess the proportion of parents interested in leaving the pediatric emergency department (ED) prior to physician assessment if they could be offered a scheduled community healthcare appointment. We explored differences in care children received in the ED stratified by interest in a community healthcare appointment and parents' reasons when they were not interested. METHODS: We conducted a 14-item survey within the pediatric ED at a Canadian tertiary care teaching hospital to assess parents' interest if a program offered community healthcare appointments and we determined preferred appointment characteristics...
October 18, 2023: CJEM
#13
REVIEW
Benedict Phillips, Ellie Asgari, Miriam Berry, Chris Callaghan, Miriam Cortes Cerisuelo, Paul Johnson, Nikolaos Karydis, David Nasralla, Anisu Nutu, Gabi Oniscu, Thamara Perera, Sanjay Sinha, Andrew Sutherland, David Van Dellen, Chris Watson, Steve White, Stephen O'Neill
The British Transplantation Society (BTS) 'Guideline on transplantation from deceased donors after circulatory death' has recently been updated and this manuscript summarises the relevant recommendations in abdominal organ transplantation from Donation after Circulatory Death (DCD) donors, encompassing the chapters on liver, kidney, pancreas and islet cell transplantation.
October 11, 2023: Transplantation Reviews
#14
JOURNAL ARTICLE
Linda Sharp, Laura-Jayne Watson, Liya Lu, Sam Harding, Katrina Hurley, Steve J Thomas, Joanne M Patterson
Cancer-related fatigue (CRF) is a common side-effect of cancer and its treatments. For head and neck cancer (HNC), CRF may exacerbate the symptom burden and poor quality-of-life. Using data from the Head and Neck 5000 prospective clinical cohort, we investigated clinically important CRF over a year post-diagnosis, assessing temporal trends, CRF by HNC site and treatment received, and subgroups at higher risk of CRF. Recruitment was undertaken in 2011-2014. Socio-demographic and clinical data, and patient-reported CRF (EORTC QLQ-C30 fatigue subscale score ≥39 of a possible 100) were collected at baseline (pre-treatment) and 4- and 12- months post-baseline...
October 5, 2023: Cancers
#15
JOURNAL ARTICLE
Eleyna M Martin, Joanne C Clark, Samantha J Montague, Luis A Morán, Ying Di, Lily J Bull, Luke Whittle, Florije Raka, Richard J Buka, Idrees Zafar, Caroline Kardeby, Alexandre Slater, Steve P Watson
BACKGROUND: Clustering of the glycoprotein receptors GPVI, CLEC-2, FcγRIIA and PEAR1 leads to powerful activation of platelets through phosphorylation of tyrosine in their cytosolic tails and initiation of downstream signalling cascades. GPVI, CLEC-2 and FcγRIIA signal through YxxL motifs that activate Syk. PEAR1 signals through a YxxM motif that activates phosphoinositide 3-kinase (PI3K). Current ligands for these receptors have an undefined valency and show significant batch variation and, for some, uncertain specificity...
October 7, 2023: Journal of Thrombosis and Haemostasis: JTH
#16
JOURNAL ARTICLE
Fawaz O Alenazy, Maan H Harbi, Dean P Kavanagh, Joshua Price, Paul Brady, Oscar Hargreaves, Paul Harrison, Alexandre Slater, Alok Tiwari, Phillip L R Nicolson, Derek L Connolly, Paulus Kirchhof, Neena Kalia, Martine Jandrot-Perrus, Pierre H Mangin, Steve P Watson, Mark R Thomas
BACKGROUND: Aspirin and platelet P2Y12 inhibitors, such as ticagrelor, suboptimally inhibit microvascular thrombosis during ST-elevation myocardial infarction (STEMI). GPIIb/IIIa inhibitors may further inhibit this, but cause excessive bleeding. We investigated whether combination of glenzocimab, a GPVI inhibitor, with aspirin and ticagrelor provides additional antithrombotic effects, as GPVI has a critical role in atherothrombosis but minimal involvement in haemostasis. METHODS: We investigated effects of glenzocimab (monoclonal antibody Fab fragment) using blood from healthy donors and patients with acute coronary syndromes (ACS) treated with aspirin and ticagrelor...
August 2, 2023: Journal of Thrombosis and Haemostasis: JTH
#17
JOURNAL ARTICLE
Joanne C Clark, Steve P Watson, Dylan M Owen
Receptor dimerisation and higher order oligomerisation regulates signalling by a wide variety of transmembrane receptors. We discuss how agent-based modelling (ABM) combined with advanced microscopy and structural studies can provide new insights into the regulation of clustering, including spatial considerations, revealing novel targets for therapeutic intervention.
July 26, 2023: Trends in Pharmacological Sciences
#18
JOURNAL ARTICLE
Rosen Chowdhury, Steve Cook, Duncan Watson
The present paper revisits and extends the examination of the long-run relationship between UK life expectancy and income provided by Tapia Granados (2012). Adopting a more detailed form of analysis, a clear break corresponding to the 1918-1919 Influenza Pandemic is identified in the long span of data examined. This finding of structural change, along with detected uncertainty regarding the orders of integration of the series examined, results in the application of split-sample analysis employing autoregressive distributed lag (ARDL) modelling...
July 19, 2023: Social Science & Medicine
#19
JOURNAL ARTICLE
Claudia Schönichen, Samantha J Montague, Sanne L N Brouns, James J Burston, Judith M E M Cosemans, Kerstin Jurk, Beate E Kehrel, Rory R Koenen, Fionnuala Ní Áinle, Valerie B O'Donnell, Oliver Soehnlein, Steve P Watson, Marijke J E Kuijpers, Johan W M Heemskerk, Magdolna Nagy
BACKGROUND: Platelets and neutrophils are the first blood cells accumulating at sites of arterial thrombus formation, and both cell types contribute to the pathology of thrombotic events. We aimed to identify key interaction mechanisms between these cells using microfluidic approaches. METHODS: Whole-blood perfusion was performed over a collagen surface at arterial shear rate. Platelet and leukocyte (in majority neutrophil) activation were microscopically visualized using fluorescent markers...
July 6, 2023: Arteriosclerosis, Thrombosis, and Vascular Biology
#20
JOURNAL ARTICLE
Natalie J Jooss, Christopher W Smith, Jeremy A Pike, Richard W Farndale, Yvonne M C Henskens, Steve P Watson, Johan W M Heemskerk, Natalie S Poulter
BACKGROUND: Collagen-induced platelet activation is predominantly mediated by glycoprotein (GP) VI through formation of receptor clusters that coincide with the accumulation of signaling molecules and are hypothesized to drive strong and sustained platelet activation. OBJECTIVES: To determine the importance of GPVI clusters for thrombus formation in whole blood under shear. METHODS: We utilized whole blood microfluidics and an anti-GPVI nanobody (Nb), Nb28, labeled with AlexaFluor 488, to assess the distribution of GPVI on the surface of platelets adhering to a range of collagen-like substrates with different platelet activation potentials...
August 2023: Journal of Thrombosis and Haemostasis: JTH
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