Roman O Kowalchuk, Trey C Mullikin, Grant M Spears, Benjamin A Johnson-Tesch, Peter S Rose, Brittany L Siontis, Dong Kun Kim, Brian A Costello, Jonathan M Morris, Robert W Gao, Satomi Shiraishi, John J Lucido, Kenneth R Olivier, Dawn Owen, Bradley J Stish, Mark R Waddle, Nadia N Laack, Sean S Park, Paul D Brown, Kenneth W Merrell
OBJECTIVES: Metastasis-directed stereotactic body radiation therapy (SBRT) has demonstrated robust clinical benefits in carefully selected patients, improving local control and even overall survival (OS). We assess a large database to determine clinical and dosimetric predictors of local failure after spine SBRT. METHODS: Spine SBRT treatments with imaging follow-up were identified. Patients were treated with a simultaneous integrated boost technique using 1 or 3 fractions, delivering 20-24 Gy in 1 fraction to the gross tumor volume (GTV) and 16 Gy to the low dose volume (or 27-36 Gy and 21-24 Gy for 3 fraction treatments)...
March 27, 2024: Radiotherapy and Oncology