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https://www.readbyqxmd.com/read/28099187/a-comparative-study-of-anterior-decompression-with-fusion-and-posterior-decompression-with-laminoplasty-for-the-treatment-of-cervical-spondylotic-myelopathy-patients-with-large-anterior-compression-of-the-spinal-cord
#1
Takashi Hirai, Toshitaka Yoshii, Yoshiyasu Arai, Kenichiro Sakai, Ichiro Torigoe, Hidetsugu Maehara, Masaki Tomori, Takashi Taniyama, Hirokazu Sato, Atsushi Okawa
STUDY DESIGN: This is a retrospective observational single-center study. OBJECTIVES: To compare anterior decompression and fusion (ADF) and laminoplasty (LAMP) for the treatment of cervical spondylotic myelopathy (CSM) patients with large anterior compression in terms of clinical and radiologic outcomes. SUMMARY OF BACKGROUND DATA: We have reported that insufficient posterior decompression could be often seen after laminoplasty for CSM patients with preoperative anterior clearance of the spinal cord, defined as an interval <4 mm between the preoperative the modified K-line and anterior structure of the spinal canal at most compressive segment on sagittal T1-weighted magnetic resonance imaging...
January 17, 2017: Clinical Spine Surgery
https://www.readbyqxmd.com/read/28089483/patterns-of-failure-after-radiotherapy-for-pediatric-patients-with-intracranial-ependymoma
#2
Fatima Tensaouti, Anne Ducassou, Léonor Chaltiel, Stéphanie Bolle, Xavier Muracciole, Bernard Coche-Dequeant, Claire Alapetite, Valérie Bernier, Line Claude, Stéphane Supiot, Aymeri Huchet, Christine Kerr, Elisabeth le Prisé, Anne Laprie
PURPOSE: To investigate the patterns of failure after radiotherapy for pediatric intracranial ependymoma and their correlation with dose parameters. METHODS: Between 2000 and 2013, 206 patients were treated in France. MRI scans at relapse were registered to the original planning CTs for topographic analysis of failure patterns. To compare relapse patients (RP) with non relapse patients (NRP), several dose parameters were derived from dose volume histograms. RESULTS: Over a median follow-up of 53...
January 12, 2017: Radiotherapy and Oncology: Journal of the European Society for Therapeutic Radiology and Oncology
https://www.readbyqxmd.com/read/28088217/surgical-treatment-of-upper-cervical-spine-metastases-a-retrospective-study-of-39-cases
#3
Jian Yang, Qi Jia, Dongyu Peng, Wei Wan, Nanzhe Zhong, Yan Lou, Xiaopan Cai, Zhipeng Wu, Chenglong Zhao, Xinghai Yang, Jianru Xiao
BACKGROUND: The surgical treatment of upper cervical spine metastases are controversial up to now. By summarizing and analyzing the clinical data of the upper cervical spine involved metastases treated surgically in our center, we mainly aimed to investigate the surgical decisions and outcomes so as to provide more references for the clinical treatment of this special and complex spine metastasis. METHODS: We evaluated the patients' pre- and post-operative neck pain and neurologic function with paired t test, followed by the statistics of the selection of surgical approaches, ways of reconstruction, and related complications...
January 14, 2017: World Journal of Surgical Oncology
https://www.readbyqxmd.com/read/28072705/posterior-only-vertebral-column-resection-for-revision-surgery-in-post-laminectomy-rotokyphoscoliosis-associated-with-late-onset-paraplegia-a-case-report-and-literature-review
#4
Youping Tao, Jigong Wu, Huasong Ma
RATIONALE: Severe post-laminectomy spinal deformity associated with late-onset paraplegia is a complex and rare disorder. Little is known about revision surgery in post-laminectomy rotokyphoscoliosis associated with late-onset paraplegia treated by the single stage posterior-only vertebral column resection (VCR) procedure. PATIENT CONCERNS AND DIAGNOSES: The patient was a 14-year-old male diagnosed as post-laminectomy rotokyphoscoliosis associated with late-onset paraplegia...
January 2017: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28058004/testicular-cancer-in-down-syndrome-with-spinal-cord-metastases
#5
Turky Almouhissen, Hattan Badr, Bassam AlMatrafi, Noor Alessa, Anmar Nassir
A 22-year-old male patient with Down syndrome was referred to our hospital with a vast left testicular mass. He underwent a left radical inguinal orchiectomy, and a histopathological examination of the mass showed a yolk sac tumor invading the epididymis. The patient was discharged in a satisfactory condition. Sixteen days later, the patient presented again complaining of lower limb weakness. Magnetic resonance imaging of the spine showed metastatic lesions compressing the dorsal spine, and he underwent emergency surgical decompression...
October 2016: Urology Annals
https://www.readbyqxmd.com/read/28057095/-comparison-of-curative-effect-and-prognosis-analysis-of-patients-with-spinal-metastases-treated-by-percutaneous-vertebroplasty-combined-with-postoperative-radiotherapy-and-radiotherapy-alone
#6
X Y Cao, Y S Liu, M X Lei, S B Liu, S G Zhou, Y C Cao, W G Jiang
Objective: To evaluate the efficacy of percutaneous vertebroplasty(PVP) combined with postoperative radiotherapy and radiotherapy alone in the treatment of spinal metastatic tumors and to evaluate the prognostic factors for survival. Methods: From December 2011 to December 2015, according to the choice of treatment, patients in group A(60 cases) were treated with PVP combined with postoperative radiotherapy and those in group B(50 cases) underwent radiotherapy alone, age, sex, primary tumor type , and other basic characteristics were analyzed in both groups in department of orthopedics and radiotherapy department, 307 Hospital of the People's Liberation Army...
December 20, 2016: Zhonghua Yi Xue za Zhi [Chinese medical journal]
https://www.readbyqxmd.com/read/28055969/tmprss2-erg-fusion-promotes-prostate-cancer-metastases-in-bone
#7
Rachel Deplus, Carine Delliaux, Nathalie Marchand, Anne Flourens, Nathalie Vanpouille, Xavier Leroy, Yvan de Launoit, Martine Duterque-Coquillaud
Bone metastasis is the major deleterious event in prostate cancer (PCa). TMPRSS2-ERG fusion is one of the most common chromosomic rearrangements in PCa. However, its implication in bone metastasis development is still unclear. Since bone metastasis starts with the tropism of cancer cells to bone through specific migratory and invasive processes involving osteomimetic capabilities, it is crucial to better our understanding of the influence of TMPRSS2-ERG expression in the mechanisms underlying the bone tropism properties of PCa cells...
December 31, 2016: Oncotarget
https://www.readbyqxmd.com/read/28048809/mo-d-brc-01-memorial-lecture
#8
B Fraass
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048786/mo-d-brc-04-multiple-criteria-optimization-planning
#9
J Donaghue
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048393/su-f-t-529-dosimetric-investigation-of-a-rotating-gamma-ray-system-for-imagedguided-modulated-arc-radiotherapy
#10
C Ma, O Chibani, A Eldib, J Li, L Chen
PURPOSE: Because of their effectiveness and efficiency, rotational arc radiotherapy (MAT) techniques have been developed on both specialty machines such as Tomotherapy and conventional linear accelerators. This work investigates a new rotating Gamma therapy system for image guided MAT and SBRT of intra/extracranial tumors. METHODS: The CyberMAT system (Cyber Medical Corp., China) consists of a ring gantry with a gamma source (effective source size 1cm and 1.7cm respectively), a 120-leaf MLC, a kV CBCT and an EPID...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048300/th-cd-206-10-clinical-application-of-the-mind-demons-algorithm-for-symmetric-diffeomorphic-deformable-mr-to-ct-image-registration-in-spinal-interventions
#11
S Reaungamornrat, T De Silva, A Uneri, J Wolinsky, A Khanna, G Kleinszig, S Vogt, J Prince, J Siewerdsen
PURPOSE: Accurate intraoperative localization of target anatomy (e.g., tumors and vertebral levels) and critical structures (e.g., nerves and vessels) is essential to safe, effective surgery. Preoperative CT/MR images can be used to identify such vital anatomy in intraoperative images through multimodality deformable registration. We proposed a deformable registration method to align preoperative MR to intraoperative CT using modality-independent neighborhood descriptors (MIND) and a Huber metric for robust registration...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048157/mo-d-brc-02-auto-planning
#12
P Xia
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28048155/th-ef-brb-04-4%C3%AF-dynamic-conformal-arc-therapy-dynamic-conformal-arc-therapy-dcat-for-sbrt
#13
T Chiu, T Long, A Modiri, Z Tian, A Sawant, Y Yan, S Jiang, X Gu
PURPOSE: To develop an efficient and effective trajectory optimization methodology for 4π dynamic conformal arc treatment (4π DCAT) with synchronized gantry and couch motion; and to investigate potential clinical benefits for stereotactic body radiation therapy (SBRT) to breast, lung, liver and spine tumors. METHODS: The entire optimization framework for 4π DCAT inverse planning consists of two parts: 1) integer programming algorithm and 2) particle swarm optimization (PSO) algorithm...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28047505/mo-d-brc-03-knowledge-based-planning
#14
Q Wu
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046910/su-f-j-108-tmr-correction-factor-based-online-adaptive-radiotherapy-for-stereotactic-radiosurgery-srs-of-l-spine-tumors-using-cone-beam-ct
#15
I Ghaffar, S Balik, T Zhuang, S Chao, P Xia
PURPOSE: To investigate the feasibility of using TMR ratio correction factors for a fast online adaptive plan to compensate for anatomical changes in stereotactic radiosurgery (SRS) of L-spine tumors. METHODS: Three coplanar treatment plans were made for 11 patients: Uniform (9 IMRT beams equally distributed around the patient); Posterior (IMRT with 9 posterior beams every 20 degree) and VMAT (2 360° arcs). For each patient, the external body and bowel gas were contoured on the planning CT and pre-treatment CBCT...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046772/su-f-j-29-dosimetric-effect-of-image-registration-roi-size-and-focus-in-automated-cbct-registration-for-spine-sbrt
#16
A Magnelli, A Smith, S Chao, J Suh, P Xia
PURPOSE: Spinal stereotactic body radiotherapy (SBRT) involves highly conformal dose distributions and steep dose gradients due to the proximity of the spinal cord to the treatment volume. To achieve the planning goals while limiting the spinal cord dose, patients are setup using kV cone-beam CT (kV-CBCT) with 6 degree corrections. The kV-CBCT registration with the reference CT is dependent on a user selected region of interest (ROI). The objective of this work is to determine the dosimetric impact of ROI selection...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046751/mo-d-brc-00-in-memoriam-of-jan-van-de-geijn-knowledge-based-planning
#17
Ping Xia
Treatment planning is a central part of radiation therapy, including delineation in tumor volumes and critical organs, setting treatment goals of prescription doses to the tumor targets and tolerance doses to the critical organs, and finally generation of treatment plans to meet the treatment goals. National groups like RTOG have led the effort to standardize treatment goals of the prescription doses to the tumor targets and tolerance doses to the critical organs based on accumulated knowledge from decades of abundant clinical trial experience...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28046622/su-f-t-214-re-thinking-the-useful-clinical-beam-energy-in-proton-therapy-an-opportunity-for-cost-reduction
#18
El H Bentefour, H Lu
PURPOSE: We conducted a retrospective study of the useful clinical proton beam energy based on the beam range data of patients treated over the last 10 years at Massachusetts General Hospital Proton Therapy Center. METHODS: Treatment field information were collected for all patients treated over the last 10 years (2005-2015) in the two gantry treatment rooms at MGH. The beam ranges for these fields were retrieved and categorized per treatment site. The 10 prostate patients that required the highest beam range (lateral fields) were selected...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28042067/a-cross-sectional-study-on-the-symptom-burden-of-patients-with-spinal-tumor-validation-of-the-chinese-version-of-the-md-anderson-symptom-inventory-spine-tumor-module-mdasi-sp
#19
Nanfang Xu, Zhehuang Li, Xiaoguang Liu, Liang Jiang, Na Meng, Ping Jiang, Miao Yu, Fengliang Wu, Lei Dang, Hua Zhou, Yan Li, Feng Wei, Zhongjun Liu
CONTEXT: Tumors involving the spine are associated with unique symptoms affecting both patient survival and health-related quality of life (HRQoL). Currently, there is no disease-specific instrument in Chinese to assess the symptom burden of these patients. OBJECTIVES: To translate and validate a Chinese version of the MD Anderson Symptom Inventory - Spine Tumor Module (MDASI-SP-C) in order to assess the symptom burden of Chinese-speaking patients with spinal tumors...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28041329/the-impact-of-histology-and-delivered-dose-on-local-control-of-spinal-metastases-treated-with-stereotactic-radiosurgery
#20
Yoshiya Yamada, Evangelia Katsoulakis, Ilya Laufer, Michael Lovelock, Ori Barzilai, Lily A McLaughlin, Zhigang Zhang, Adam M Schmitt, Daniel S Higginson, Eric Lis, Michael J Zelefsky, James Mechalakos, Mark H Bilsky
OBJECTIVE An analysis of factors contributing to durable radiographic control of spinal metastases was undertaken, drawing from a large single-institution database in an attempt to elucidate indications and dose requirements for successful treatment. METHODS All patients treated at a single institution with stereotactic radiosurgery (SRS) of the spine as first-line therapy were assessed for local progression of the treated site, defined as radiographic enlargement of the treated tumor and/or biopsy-proven evidence of active tumor cells...
January 2017: Neurosurgical Focus
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