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Elderly and sleep apnea

Magali Saint Martin, Emilia Sforza, Emilie Crawford-Achour, Lefèvre Pascal, Georges Lienard, Roche Frédéric
OBJECTIVE: Sleep breathing disorders (SBD) are the most common sleep disorders frequently under-diagnosed in elderly populations. However, it is it well known that this disorder may contribute to the age-related cognitive decline. In a cohort of healthy elderly subjects, we performed an 8-year longitudinal study to assess whether changes in cognitive function occur in untreated SBD elderly and the nocturnal factors implicated in these changes. MATERIAL/PATIENTS AND METHODS: A total of 559 participants of the community-based PROOF study aged 67years at the study entry and free from neurological disorders were examined...
September 2016: Annals of Physical and Rehabilitation Medicine
John E Morley
Frailty is a pre-disability syndrome where an older person can be identified as being at risk when exposed to stressors associated with high risk for disability or needing to be hospitalized. Two major frailty definitions exist. The physical phenotype of frailty and the multiple deficit model. A simple frailty screening tool-FRAIL-has been validated. Treatment of frailty involves resistance exercise, optimization of nutrition, and treatment of fatigue (sleep apnea, depression), treatable causes of weight loss and adjustment of polypharmacy...
September 26, 2016: Wiener Klinische Wochenschrift
Malcolm Koo, Juen-Haur Hwang
OBJECTIVE: To investigate the risk of tinnitus in patients with sleep disturbance or sleep apnea. STUDY DESIGN: Case control study. METHODS: We identified 21,798 middle-aged and elderly patients with otolaryngologist-diagnosed tinnitus between January 1, 2000, and December 31, 2012, from the Longitudinal Health Insurance Database 2000 of the Taiwan National Health Insurance Research Database. A total of 108,990 controls were also identified from the same database based on frequency-matching on 10-year age interval, sex, and year of index date of the cases...
September 26, 2016: Laryngoscope
Mohammad Farajzadeh, Meimanat Hosseini, Jamileh Mohtashami, Samira Chaibakhsh, Mansoureh Zagheri Tafreshi, Reza Ghanei Gheshlagh
BACKGROUND: Depression is the most frequent psychiatric disorder among the elderly. Obstructive sleep apnea (OSA) is a chronic and prevalent disease that has an ambiguous role in triggering depression. Several researches with contradictory findings have been performed about the association between OSA and depression. OBJECTIVES: This study aimed to investigate the association between OSA and depression among elderly. PATIENTS AND METHODS: A total of 350 home residing elderly took part in this case-control study...
June 2016: Nursing and Midwifery Studies
Chamara V Senaratna, Jennifer L Perret, Caroline J Lodge, Adrian J Lowe, Brittany E Campbell, Melanie C Matheson, Garun S Hamilton, Shyamali C Dharmage
With this systematic review we aimed to determine the prevalence of obstructive sleep apnea (OSA) in adults in the general population and how it varied between population sub-groups. Twenty-four studies out of 3807 found by systematically searching PubMed and Embase databases were included in this review. Substantial methodological heterogeneity in population prevalence studies has caused a wide variation in the reported prevalence, which, in general, is high. At ≥5 events/h apnea-hypopnea index (AHI), the overall population prevalence ranged from 9% to 38% and was higher in men...
July 18, 2016: Sleep Medicine Reviews
Emilia Sforza, Magali Saint Martin, Thierry Thomas, Philippe Collet, Martin Garet, Jean Claude Barthélémy, Frédéric Roche
OBJECTIVE: Several studies suggest a relationship between bone mineral density (BMD) anthropometric and metabolic variables, and obstructive sleep apnea (OSA); all of these factors have an effect on osteoporosis (OS) risk. This cross-sectional study explores these associations in a large sample of older subjects with and without OSA. METHODS: Volunteers were recruited from the PROgnostic indicator OF cardiovascular and cerebrovascular events survey. A total of 461 subjects, aged 68...
June 2016: Sleep Medicine
Richard Mahlberg
Sleep disturbances are common in the elderly. Endogen regulation mechanisms are often unstable. Light treatment and melatonin are proved chronobiological interventions. Cataract surgery is effective to enhance the sleep-wake-rhythm.Mandibular advancement devices are a reliable alternative to continuous positive air pressure (CPAP) in obstructive sleep apnea syndrome (OSAS).
August 2016: Deutsche Medizinische Wochenschrift
Yi Su, Weiwei Xu, Xiangyun Wang, Zhili Zhang, Yingchun Cao, Qiuhong Yu, Jiandong Li
OBJECTIVE: To survey the prevalence of obstructive sleep apnea-hypopnea syndrome(OSAHS) in adults aged over 60 years in Dongying city,and analyze the risk factors and the extent of damage to the quality of life for the elderly to provide the basis for prevention and treatment of OSAHS people. METHOD: One thousand subjects were derived from a random cluster sampling in seven districts of Dongying city:they were asked to answer the questions from questionnaires. According to the questionnaire scoring, 100 subjects in high-risk group were selected randomly to make polysomnography monitoring for a whole night,so that the prevalence of the disease was calculated and the related risk factors were analyzed; elderly patients diagnosed with OSAHS were asked to assess the quality of life assessment questionnaire by face to face to understand the quality of life dimensions injury...
February 2016: Journal of Clinical Otorhinolaryngology, Head, and Neck Surgery
Mak Adam Daulatzai
Aging, hypertension, diabetes, hypoxia/obstructive sleep apnea (OSA), obesity, vitamin B12/folate deficiency, depression, and traumatic brain injury synergistically promote diverse pathological mechanisms including cerebral hypoperfusion and glucose hypometabolism. These risk factors trigger neuroinflammation and oxidative-nitrosative stress that in turn decrease nitric oxide and enhance endothelin, Amyloid-β deposition, cerebral amyloid angiopathy, and blood-brain barrier disruption. Proinflammatory cytokines, endothelin-1, and oxidative-nitrosative stress trigger several pathological feedforward and feedback loops...
June 27, 2016: Journal of Neuroscience Research
Sean A Martin, Sarah L Appleton, Robert J Adams, Anne W Taylor, Peter G Catcheside, Andrew Vakulin, R Douglas McEvoy, Nick A Antic, Gary A Wittert
OBJECTIVES: To examine the influence of obstructive sleep apnea (OSA) on nocturia, controlling for their shared co-morbidities, in a population of community-based middle aged to elderly men. METHODS: Participants were drawn from a randomly-selected, community-dwelling cohort of men in Adelaide, Australia. 708 men (mean:60.7 [41.6-88.2] years) who had PSG recordings, complete LUTS measures (IPSS), without prostate or bladder cancer and/or surgery, and no prior OSA diagnosis were selected...
June 24, 2016: Urology
Mak Adam Daulatzai
Sporadic Alzheimer's disease (AD) is a devastating neurodegenerative disorder. It is essential to unravel its etiology and pathogenesis. This should enable us to study the presymptomatic stages of the disease and to analyze and reverse the antemortem behavioral, memory, and cognitive dysfunction. Prima facie, an ongoing chronic vulnerability involving neural insult may lead normal elderly to mild cognitive impairment (MCI) and then to AD. Development of effective preventive and therapeutic strategies to thwart the disease pathology obviously requires a thorough delineation of underlying disruptive neuropathological processes...
October 2016: Neurotoxicity Research
Claire Boutet, Syad Abdirahman Mohamed Moussa, Sébastien Celle, Bernard Laurent, Jean-Claude Barthélémy, Fabrice-Guy Barral, Frédéric Roche
OBJECTIVE: Small upper airway measurements areas and high body mass index are recognized risk factors for obstructive sleep apnea syndrome (OSAS) in non-elderly populations; however, there is limited information regarding elderly patients. We evaluated whether upper airway volume is associated with OSAS and OSAS treated with continuous positive airway pressure (CPAP) treatment and whether BMI is correlated with upper airway volume and measurements in elderly subjects. METHODS: In 60 volunteers aged 75...
2016: PloS One
Kazuhiro Hongyo, Norihisa Ito, Koichi Yamamoto, Yukiko Yasunobe, Masao Takeda, Ryosuke Oguro, Yoichi Takami, Yasushi Takeya, Ken Sugimoto, Hiromi Rakugi
AIM: Epidemiological studies have shown that severe obstructive sleep apnea (OSA) is associated with higher mortality when compared with mild to moderate OSA. Because aging is a well-known risk factor for OSA, we aimed to elucidate the underlying factors associated with the severity of OSA in elderly patients. METHODS: Patients who underwent polysomnography were divided into the non-elderly group (aged <65 years; n = 44) and the elderly group (aged ≥65 years; n = 46)...
June 1, 2016: Geriatrics & Gerontology International
Emilia Sforza, Magali Saint Martin, Jean Claude Barthélémy, Frédéric Roche
OBJECTIVE: Previous studies have suggested an association between obstructive sleep apnea (OSA) and anxiety and depression, but it remains unclear as to whether this is due to OSA or other factors. The aim of this study was to evaluate this association in a large sample of healthy elderly with unrecognized OSA. METHODS: 825 healthy elderly (aged ≥65 years) undergoing clinical, respiratory home polygraphic study and completion of questionnaires related to depression, anxiety and sleepiness were examined...
March 2016: Sleep Medicine
Daniel López-Padilla, Rodrigo Alonso-Moralejo, Miguel Ángel Martínez-García, Salvador De la Torre Carazo, María Josefa Díaz de Atauri
OBJECTIVE: There is evidence of a beneficial effect of long-term continuous positive airway pressure (CPAP) on survival in elderly persons with obstructive sleep apnea (OSA), although the usual age cut off is between 60 and 70 years of age. Our objective was to determine this effect in very elderly patients (ie, those ≥80 years of age). METHODS: An observational study of a historic cohort of very elderly persons with moderate to severe OSA (apnea-hypopnea index ≥20) and the effect of long-term CPAP on their survival was performed...
March 2016: Sleep Medicine
Nancy A Kerner, Steven P Roose
Obstructive sleep apnea (OSA) is highly prevalent but very frequently undiagnosed. OSA is an independent risk factor for depression and cognitive impairment/dementia. Herein the authors review studies in the literature pertinent to the effects of OSA on the cerebral microvascular and neurovascular systems and present a model to describe the key pathophysiologic mechanisms that may underlie the associations, including hypoperfusion, endothelial dysfunction, and neuroinflammation. Intermittent hypoxia plays a critical role in initiating and amplifying these pathologic processes...
June 2016: American Journal of Geriatric Psychiatry
J-N Cornu, G Amarenco, F Bruyere, E Chartier-Kastler, B Fatton, P Grise, F Haab, R Bourouina
AIMS: To determine the prevalence of overactive bladder (OAB) syndrome in France and gather data about initial patient trajectories in the healthcare system. METHODS: A dedicated questionnaire (41 questions) has been sent to a 12,000 sample of people representative of the global population. The following data were investigated: social and demographic features, medical history, Urinary Symptom Profile questionnaire, bother, history of symptoms, care seeking and treatments received...
June 2016: Progrès en Urologie
Ying Y Zhao, Terri Blackwell, Kristine E Ensrud, Katie L Stone, Theodore A Omachi, Susan Redline
STUDY OBJECTIVES: To evaluate the association between obstructive airway disease (OAD) and sleep apnea in older men. METHODS: A community-based cross-sectional study of 853 community-dwelling older men (mean age 80.7 ± 4.1 years [range 73 to 90]) across 6 centers in the United States from the Outcomes of Sleep Disorders in Older Men Study. Sleep was objectively measured using full in-home polysomnography and lung function was objectively measured using spirometry...
2016: Sleep
Yu Jin Lee, Jong Won Kim, Yu-Jin G Lee, Do-Un Jeong
OBJECTIVE: In the present study, it was hypothesized that the sleep electroencephalogram (EEG) characteristics of young (<30 yrs) and elderly (>55 yrs) OSAS patients would differ. METHODS: We analyzed 76 sleep EEG recordings from OSAS patients (young group: n=40, mean age: 24.3±4.9 yrs; elderly group: n=36, mean age: 59.1±4.9 yrs), which were obtained during nocturnal polysomnography. The recordings were assessed via spectral analysis in the delta (0.5-4...
March 2016: Psychiatry Investigation
Ricardo S Osorio, Emma L Ducca, Margaret E Wohlleber, Emily B Tanzi, Tyler Gumb, Akosua Twumasi, Samuel Tweardy, Clifton Lewis, Esther Fischer, Viachaslau Koushyk, Maria Cuartero-Toledo, Mohammed O Sheikh, Elizabeth Pirraglia, Henrik Zetterberg, Kaj Blennow, Shou-En Lu, Lisa Mosconi, Lidia Glodzik, Sonja Schuetz, Andrew W Varga, Indu Ayappa, David M Rapoport, Mony J de Leon
STUDY OBJECTIVES: To evaluate the role of orexin-A with respect to cerebrospinal fluid (CSF) Alzheimer disease (AD) biomarkers, and explore its relationship to cognition and sleep characteristics in a group of cognitively normal elderly individuals. METHODS: Subjects were recruited from multiple community sources for National Institutes of Health supported studies on normal aging, sleep and CSF biomarkers. Sixty-three participants underwent home monitoring for sleep-disordered breathing, clinical, sleep and cognitive evaluations, as well as a lumbar puncture to obtain CSF...
2016: Sleep
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