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https://www.readbyqxmd.com/read/28081459/targeted-delivery-of-in-situ-pcr-amplified-sleeping-beauty-transposon-genes-to-cancer-cells-with-lipid-based-nanoparticle-like-protocells
#1
Kun Ma, Duo Fu, Dongli Yu, Changhao Cui, Li Wang, Zhaoming Guo, Chuanbin Mao
A Sleeping Beauty (SB) transposon system is made of a transposon plasmid (containing gene encoding a desired functional or therapeutic protein) and a transposase plasmid (encoding an enzyme capable of cutting and pasting the gene into the host cell genome). It is a kind of natural, nonviral gene delivery vehicle, which can achieve efficient genomic insertion, providing long-term transgenic expression. However, before the SB transposon system could play a role in promoting gene expression, it has to be delivered efficiently first across cell membrane and then into cell nuclei...
January 2, 2017: Biomaterials
https://www.readbyqxmd.com/read/28079877/genome-wide-transposon-screening-and-quantitative-insertion-site-sequencing-for-cancer-gene-discovery-in-mice
#2
Mathias J Friedrich, Lena Rad, Iraad F Bronner, Alexander Strong, Wei Wang, Julia Weber, Matthew Mayho, Hannes Ponstingl, Thomas Engleitner, Carolyn Grove, Anja Pfaus, Dieter Saur, Juan Cadiñanos, Michael A Quail, George S Vassiliou, Pentao Liu, Allan Bradley, Roland Rad
Transposon-mediated forward genetics screening in mice has emerged as a powerful tool for cancer gene discovery. It pinpoints cancer drivers that are difficult to find with other approaches, thus complementing the sequencing-based census of human cancer genes. We describe here a large series of mouse lines for insertional mutagenesis that are compatible with two transposon systems, PiggyBac and Sleeping Beauty, and give guidance on the use of different engineered transposon variants for constitutive or tissue-specific cancer gene discovery screening...
February 2017: Nature Protocols
https://www.readbyqxmd.com/read/28068155/the-cost-of-survival-an-exploration-of-colorectal-cancer-survivors-experiences-of-pain
#3
Amanda Drury, Sheila Payne, Anne-Marie Brady
BACKGROUND: The Institute of Medicine report 'From Cancer Patient to Cancer Survivor' has drawn widespread attention to the experiences of cancer survivors. Research examining the symptom experiences of survivors are proliferative within the literature but limited by samples which include multiple tumor groups and varying inclusion criteria. This cross-sectional quantitative study seeks to examine pain and quality of life (QoL) in the context of colorectal cancer (CRC) survivorship, as defined by the Institute of Medicine...
January 9, 2017: Acta Oncologica
https://www.readbyqxmd.com/read/28064385/review-of-yoga-therapy-during-cancer-treatment
#4
REVIEW
Suzanne C Danhauer, Elizabeth L Addington, Stephanie J Sohl, Alejandro Chaoul, Lorenzo Cohen
PURPOSE: Reviews of yoga research that distinguish results of trials conducted during (versus after) cancer treatment are needed to guide future research and clinical practice. We therefore conducted a review of non-randomized studies and randomized controlled trials of yoga interventions for children and adults undergoing treatment for any cancer type. METHODS: Studies were identified via research databases and reference lists. Inclusion criteria were the following: (1) children or adults undergoing cancer treatment, (2) intervention stated as yoga or component of yoga, and (3) publication in English in peer-reviewed journals through October 2015...
January 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28064384/gut-microbiota-composition-associated-with-alterations-in-cardiorespiratory-fitness-and-psychosocial-outcomes-among-breast-cancer-survivors
#5
Jesseca A Paulsen, Travis S Ptacek, Stephen J Carter, Nianjun Liu, Ranjit Kumar, LaKeshia Hyndman, Elliot J Lefkowitz, Casey D Morrow, Laura Q Rogers
PURPOSE: In this proof-of-concept pilot study, our purpose was to determine correlations between gut microbiota composition and alterations in cardiorespiratory fitness and psychosocial outcomes among post-primary treatment breast cancer survivors (BCS). METHODS: Composition of the gut microbiota in BCS (n = 12) was assessed at baseline (M0) and at the end of 3 months (M3) using Illumina MiSeq DNA Sequencing of the 16S rRNA gene. Gut microbiota composition was analyzed using the QIIME bioinformatics software and represented through diversity metrics and taxa analyses...
January 7, 2017: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28063861/common-and-distinct-characteristics-associated-with-trajectories-of-morning-and-evening-energy-in-oncology-patients-receiving-chemotherapy
#6
Hamza Abid, Kord M Kober, Betty Smoot, Steven M Paul, Marilyn Hammer, Jon D Levine, Kathryn Lee, Fay Wright, Bruce A Cooper, Yvette P Conley, Christine Miaskowski
CONTEXT: While energy conservation strategies are recommended in clinical practice guidelines, little is known about changes in energy levels in oncology patients undergoing cancer treatment. OBJECTIVES: To identify variations in the trajectories of morning and evening energy levels and to determine which characteristics predicted initial levels as well as the trajectories of morning and evening energy. METHODS: Outpatients receiving chemotherapy (CTX) completed demographic and symptom questionnaires six times over two CTX cycles...
January 4, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28062488/correction-sleep-and-breathing-%C3%A2-and-cancer
#7
(no author information available yet)
No abstract text is available yet for this article.
January 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28062343/symptom-clusters-change-over-time-in-women-receiving-adjuvant-chemotherapy-for-breast-cancer
#8
Randa M Albusoul, Ann M Berger, Caryl L Gay, Susan L Janson, Kathryn A Lee
CONTEXT: Patients with breast cancer receiving chemotherapy (CTX) experience multiple concurrent symptoms, but little is known about how symptoms change during and after treatment. Knowledge of the identity and trajectory of symptom clusters (SCs) would enhance measurement and management. OBJECTIVES: We aimed to identify SCs and their change over time from baseline to completion of breast cancer CTX. METHODS: SCs were identified and assessed for change in 219 women from Nebraska at four times: baseline, during cycles #3 and #4 of CTX, and one-month after finishing CTX...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28062340/differences-in-symptom-burden-among-cancer-patients-with-different-stages-of-cachexia
#9
Ting Zhou, Kaixiang Yang, Sudip Thapa, Huiquan Liu, Bangyan Wang, Shiying Yu
CONTEXT: Cancer patients with cachexia may suffer from significant burden of symptoms and it can severely impair patients' quality of life. However, only few studies have targeted the symptom burden in cancer cachexia patients, and whether the symptom burden differed in different cachexia stages is still unclear. OBJECTIVES: The aims of this study were to evaluate the symptom burden in cancer cachexia patients, and to compare the severity and occurrence rates of symptoms among cancer patients with non-cachexia, pre-cachexia, cachexia and refractory cachexia...
January 3, 2017: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28061004/objective-physical-and-mental-markers-of-self-reported-fatigue-in-women-undergoing-neo-adjuvant-chemotherapy-for-early-stage-breast-cancer
#10
Joanne E Mortimer, Sarah Waliany, Christina M Dieli-Conwright, Sunita K Patel, Arti Hurria, Joseph Chao, Brian Tiep, Carolyn E Behrendt
BACKGROUND: Objective, treatment-independent markers of cancer-related fatigue are needed to advance clinical trials. In the current study, the authors evaluated physical, neurocognitive, and serologic markers for correlation with self-reported fatigue before and after (neo)adjuvant chemotherapy for patients with early-stage breast cancer. METHODS: Women with AJCC TNM Stage I-III breast cancer consented to assessment before and after the completion of 4 cycles of dose-dense doxorubicin and cyclophosphamide...
January 6, 2017: Cancer
https://www.readbyqxmd.com/read/28050924/inpatient-acupuncture-at-a-major-cancer-center
#11
M Kay Garcia, Lorenzo Cohen, Michael Spano, Amy Spelman, Yousra Hashmi, Alejandro Chaoul, Qi Wei, Gabriel Lopez
BACKGROUND: Use of complementary and integrative therapies is increasing among cancer patients, but data regarding the impact treatments such as acupuncture have in an inpatient oncology setting are limited. METHODS: Patients who received acupuncture in an inpatient hospital environment between December 2014 and December 2015 were asked to complete a modified Edmonton Symptom Assessment Scale (ESAS; 0-10 scale) before and after each visit. Pre- and post-treatment scores were examined for each symptom using paired t tests...
December 1, 2016: Integrative Cancer Therapies
https://www.readbyqxmd.com/read/28049126/comorbidities-in-interstitial-lung-diseases
#12
REVIEW
George A Margaritopoulos, Katerina M Antoniou, Athol U Wells
Fibrosing lung disorders include a large number of diseases with diverse behaviour. Patients can die because of the progression of their illness, remain stable or even improve after appropriate treatment has been instituted. Comorbidities, such as acute and chronic infection, gastro-oesophageal reflux, pulmonary hypertension, lung cancer, cardiovascular diseases, and obstructive sleep apnoea, can pre-exist or develop at any time during the course of the disease and, if unidentified and untreated, may impair quality of life, impact upon the respiratory status of the patients, and ultimately lead to disease progression and death...
January 2017: European Respiratory Review: An Official Journal of the European Respiratory Society
https://www.readbyqxmd.com/read/28048806/su-g-iep4-05-experience-with-a-practical-approach-to-the-release-of-radioactive-patients-from-radiation-safety-isolation
#13
R Wendt, W Erwin, A Fisher, S Jones, S Jimenez, F Wong, A Jessop
PURPOSE: The radioactive patient releases of the nuclear medicine department in a large cancer center were analyzed to compare the estimated doses to others to the regulatory limit and institutional targets and to gauge how onerous the patients' instructions were. METHODS: In-house software that implements the NUREG 1556 approach and further considers fellow travelers, children and pregnant women and members of the public following Siegel, et al., is used to calculate release timing and to provide patients with individualized instructions...
June 2016: Medical Physics
https://www.readbyqxmd.com/read/28045699/agenda-for-sleep-research-in-older-adults-with-cancer-a-conference-report
#14
Ellyn E Matthews, Eileen Danaher Hacker, Julie L Otte, Grace E Dean
BACKGROUND: Sleep problems are common but often neglected in older adults, particularly in the context of cancer. Underlying mechanisms are poorly understood and interventions frequently lack a clear scientific basis. OBJECTIVE: The objective of this report was to examine scientific content presented at a National Institutes of Health-sponsored U13 "Bedside to Bench" conference using a qualitative and iterative review procedure. Analysis of current scientific issues regarding sleep in older adults with cancer is needed to direct nurse scientists and clinicians toward research opportunities...
December 30, 2016: Cancer Nursing
https://www.readbyqxmd.com/read/28045199/yoga-for-improving-health-related-quality-of-life-mental-health-and-cancer-related-symptoms-in-women-diagnosed-with-breast-cancer
#15
REVIEW
Holger Cramer, Romy Lauche, Petra Klose, Silke Lange, Jost Langhorst, Gustav J Dobos
BACKGROUND: Breast cancer is the cancer most frequently diagnosed in women worldwide. Even though survival rates are continually increasing, breast cancer is often associated with long-term psychological distress, chronic pain, fatigue and impaired quality of life. Yoga comprises advice for an ethical lifestyle, spiritual practice, physical activity, breathing exercises and meditation. It is a complementary therapy that is commonly recommended for breast cancer-related impairments and has been shown to improve physical and mental health in people with different cancer types...
January 3, 2017: Cochrane Database of Systematic Reviews
https://www.readbyqxmd.com/read/28042077/symptom-burden-in-advanced-soft-tissue-sarcoma
#16
Nicholas Gough, Jonathan Koffman, Joy R Ross, Julia Riley, Ian Judson
CONTEXT: There is little information on symptom prevalence and severity in advanced soft tissue sarcoma (STS). Understanding symptom burden will aid clinical consultations, clarify which symptom interventions are needed and better define optimum timings of palliative and supportive care referrals. OBJECTIVES: To describe symptom prevalence and severity in patients undergoing different treatment options for advanced STS: [i] First-line palliative chemotherapy (FLC) [ii] Active surveillance (AS) pre and post-FLC and [iii] Palliative care (PC) alone...
December 29, 2016: Journal of Pain and Symptom Management
https://www.readbyqxmd.com/read/28041630/the-analgesic-effect-of-orexin-a-in-a-murine-model-of-chemotherapy-induced-neuropathic-pain
#17
Satoshi Toyama, Naohito Shimoyama, Megumi Shimoyama
Orexins are neuropeptides that are localized to neurons in the lateral and dorsal hypothalamus but its receptors are distributed to many different regions of the central nervous system. Orexins are implicated in a variety of physiological functions including sleep regulation, energy homeostats, and stress reactions. Furthermore, orexins administered exogenously have been shown to have analgesic effects in animal models. A type of intractable pain in patients is pain due to chemotherapy-induced peripheral neuropathy (CIPN)...
December 24, 2016: Neuropeptides
https://www.readbyqxmd.com/read/28032218/symptom-clusters-during-palliative-chemotherapy-and-their-influence-on-functioning-and-quality-of-life
#18
Sun Young Rha, Jiyeon Lee
INTRODUCTION: Symptom management in patients undergoing palliative chemotherapy is challenging, as patients may suffer from cancer symptoms as well as symptoms related to chemotherapy. Symptom clusters are interrelated symptoms occurring simultaneously that exert a negative impact on survival. Identification of symptom clusters and effective symptom management for patients receiving palliative chemotherapy is crucial. OBJECTIVES: The purpose of this study was to identify symptom clusters among cancer patients undergoing palliative chemotherapy and examine the relationship between symptom clusters and functioning and quality of life (QOL) in these patients...
December 28, 2016: Supportive Care in Cancer: Official Journal of the Multinational Association of Supportive Care in Cancer
https://www.readbyqxmd.com/read/28029667/outcomes-bronchoscopic-evaluation-in-a-university-hospital
#19
R H Ghimire, N Bhatta, P Koirala, B Bista, D R Misra, B Shah
INTRODUCTION: Study of clinical profile of the patients and diagnostic yield of the selected bronchoscopic procedures gives us important information in clinical decision making and better patient care. There are hardly very few studies regarding these entities. Therefore, we decided to study clinical characteristics and outcomes of the patients who underwent bronchoscopic evaluation in our setting. METHODS: This was a cross-sectional study the consecutive patients who underwent bronchoscopy from 1st May 2013- 30th April 2015 in division of pulmonary, critical care and sleep medicine...
October 2016: JNMA; Journal of the Nepal Medical Association
https://www.readbyqxmd.com/read/28012806/shift-work-and-shift-work-sleep-disorder-clinical-and-organizational-perspectives
#20
REVIEW
Emerson M Wickwire, Jeanne Geiger-Brown, Steven M Scharf, Christopher L Drake
Throughout the industrialized world, nearly one in five employees works some form of non-traditional shift. Such shift work is associated with numerous negative health consequences, ranging from cognitive complaints to cancer, as well as diminished quality of life. Further, a substantial percentage of shift workers develop shift work disorder (SWD), a circadian rhythm sleep disorder characterized by excessive sleepiness, insomnia, or both as a result of shift work. In addition to adverse health consequences and diminished quality of life at the individual level, SWD incurs significant costs to employers through diminished workplace performance and increased accidents and errors...
December 21, 2016: Chest
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