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https://www.readbyqxmd.com/read/29682302/impact-of-an-educational-video-as-a-consent-tool-on-knowledge-about-cure-research-among-patients-and-caregivers-at-hiv-clinics-in-south-africa
#1
EDITORIAL
Melany Hendricks, Gonasagrie Nair, Ciara Staunton, Michael Pather, Nigel Garrett, Dianno Baadjies, Martin Kidd, Keymanthri Moodley
Background: Despite increasing access to antiretroviral therapy in low- and middle-income countries, only 54% of eligible individuals were receiving treatment in Africa by 2015. Recent developments in HIV cure research have been encouraging. However, the complex science and procedures of cure research render the informed consent process challenging. Objective: This study evaluates the impact of a video tool on educating participants about HIV cure. Methods: A questionnaire assessing the content of the video was administered to adults recruited from two clinics in South Africa...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682301/ethical-challenges-in-developing-an-educational-video-to-empower-potential-participants-during-consent-processes-in-hiv-cure-research-in-south-africa
#2
EDITORIAL
Ciara Staunton, Malcolm de Roubaix, Dianno Baatjies, Gill Black, Melany Hendricks, Theresa Rossouw, Keymanthri Moodley
Obtaining consent for HIV research is complex, particularly in low- and middle-income countries. Low levels of education, complexity of science and research processes, confusion about basic elements of research, and socio-economic conditions that make access to medical care difficult have collectively led to concerns about the adequacy of the consent process. Given the exponential growth of HIV prevention and treatment research in South Africa, HIV researchers are increasingly facing challenges obtaining authentic informed consent from potential participants...
April 1, 2018: Journal of Virus Eradication
https://www.readbyqxmd.com/read/29682294/duragraft-vascular-conduit-preservation-solution-in-patients-undergoing-coronary-artery-bypass-grafting-rationale-and-design-of-a-within-patient-randomised-multicentre-trial
#3
Walid Ben Ali, Pierre Voisine, Peter Skov Olsen, Hugues Jeanmart, Nicolas Noiseux, Tracy Goeken, Vilas Satishchandran, Filippo Cademartiri, Garry Cutter, Dave Veerasingam, Craig Brown, Maximilian Y Emmert, Louis P Perrault
Introduction: Saphenous vein grafts (SVGs) remain the most often used conduits in coronary artery bypass grafting (CABG). However, they are prone to vein graft disease (VGD) during follow-up, which may compromise clinical outcomes. Injury to the SVG endothelium during harvesting and storage promotes neointimal hyperplasia that can advance to atherosclerosis characterised by SVG failure. This trial investigates the potential benefit of DuraGraft, a novel, one-time intraoperative graft treatment developed to efficiently protect the structural and functional integrity of the vascular endothelium, on the development and progression of VGD in CABG patients...
2018: Open Heart
https://www.readbyqxmd.com/read/29682032/analysis-of-factors-influencing-outcome-of-depressed-fracture-of-skull
#4
Ritesh S Satardey, Srikant Balasubramaniam, Jayashree S Pandya, Rajesh C Mahey
Context: The outcome of patients with depressed fracture varies and depends on multiple factors. There has been no previous study on the significance of these factors on the outcome of depressed fracture of the skull and hence this study. Aims: The primary aim of our study is to find the factors affecting the outcome in cases of depressed skull fracture (DSF). This will help us improve outcomes and give more accurate prediction of long-term outcomes. Settings and Design: Prospective observational study...
April 2018: Asian Journal of Neurosurgery
https://www.readbyqxmd.com/read/29681041/ethics-certification-of-health-information-professionals
#5
Eike-Henner Kluge, Paulette Lacroix, Pekka Ruotsalainen
OBJECTIVES:  To provide a model for ensuring the ethical acceptability of the provisions that characterize the interjurisdictional use of eHealth, telemedicine, and associated modalities of health care deliveiy that are currently in place. METHODS:  Following the approach initiated in their Global Protection of Health Data project within the Security in Health Information Systems (SiHIS) working group of the International Medical Informatics Association (IMIA), the authors analyze and evaluate relevant privacy and security approaches that are intended to stem the erosion of patients' trustworthiness in the handling of their sensitive information by health care and informatics professionals in the international context...
April 22, 2018: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29681039/the-safe-and-effective-use-of-shared-data-underpinned-by-stakeholder-engagement-and-evaluation-practice
#6
Andrew Georgiou, Farah Magrabi, Hannele Hypponen, Zoie Shui-Yee Wong, Pirkko Nykänen, Philip J Scott, Elske Ammenwerth, Michael Rigby
OBJECTIVES:  The paper draws attention to: i) key considerations involving the confidentiality, privacy, and security of shared data; and ii) the requirements needed to build collaborative arrangements encompassing all stakeholders with the goal of ensuring safe, secure, and quality use of shared data. METHOD:  A narrative review of existing research and policy approaches along with expert perspectives drawn from the International Medical Informatics Association (IMIA) Working Group on Technology Assessment and Quality Development in Health Care and the European Federation for Medical Informatics (EFMI) Working Group for Assessment of Health Information Systems...
April 22, 2018: Yearbook of Medical Informatics
https://www.readbyqxmd.com/read/29680815/patient-trajectories-and-their-impact-on-mobility-social-participation-and-quality-of-life-in-patients-with-vertigo-dizziness-balance-disorders-and-osteoarthritis-mobile-tra-study-protocol-of-an-observational-practice-based-cohort-study
#7
Rebecca Kisch, Antje Bergmann, Daniela Koller, Reiner Leidl, Ulrich Mansmann, Martin Mueller, Linda Sanftenberg, Joerg Schelling, Leonie Sundmacher, Karen Voigt, Eva Grill
INTRODUCTION: Mobility limitations have a multitude of different negative consequences on elderly patients including decreasing opportunities for social participation, increasing the risk for morbidity and mortality. However, current healthcare has several shortcomings regarding mobility sustainment of older adults, namely a narrow focus on the underlying pathology, fragmentation of care across services and health professions and deficiencies in personalising care based on patients' needs and experiences...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680814/spect-v-q-for-the-diagnosis-of-pulmonary-embolism-protocol-for-a-systematic-review-and-meta-analysis-of-diagnostic-accuracy-and-clinical-outcome
#8
Pierre-Yves Le Roux, Philippe Robin, Cécile Tromeur, Alexandra Davis, Helia Robert-Ebadi, Marc Carrier, Francis Couturaud, Grégoire Le Gal, Pierre-Yves Salaun
INTRODUCTION: Single photon emission computed tomography ventilation/perfusion (SPECT V/Q) imaging has many proponents within the nuclear medicine community and has already largely replaced planar V/Q scintigraphy in daily practice for the diagnosis of pulmonary embolism (PE). However, the test is still described in clinical guidelines as an experimental test because of insufficient evidence. METHODS AND ANALYSIS: We will conduct a systematic review and a meta-analysis of diagnostic accuracy and management outcome studies involving patients evaluated with V/Q SPECT for suspected acute PE...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680812/a-smartphone-application-for-reporting-symptoms-in-adults-with-cystic-fibrosis-protocol-of-a-randomised-controlled-trial
#9
Jamie Wood, Sue Jenkins, David Putrino, Siobhain Mulrennan, Sue Morey, Nola Cecins, Kylie Hill
INTRODUCTION: In people with cystic fibrosis (CF), exacerbations have been shown to have profound and prolonged negative effects such as reducing physical activity and health-related quality of life, increasing the rate of decline of lung function and healthcare costs, and ultimately increasing the risk of mortality. Delayed initiation of treatment following the signs of an exacerbation has been shown to be associated with failure to recover to baseline. Therefore, the late identification and treatment of an exacerbation due to delayed presentation will potentially worsen short-term and long-term outcomes...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680811/does-the-age-of-acute-care-physicians-impact-their-1-crisis-management-performance-and-2-learning-after-simulation-based-education-a-protocol-for-a-multicentre-prospective-cohort-study-in-toronto-and-ottawa-canada
#10
Fahad Alam, Vicki R LeBlanc, Alan Baxter, Jordan Tarshis, Dominique Piquette, Yuqi Gu, Caroline Filipkowska, Ashley Krywenky, Nicole Kester-Greene, Pierre Cardinal, Shelly Au, Sandy Lam, Sylvain Boet, Perioperative Anesthesia Clinical Trials Group
INTRODUCTION: The proportion of older acute care physicians (ACPs) has been steadily increasing. Ageing is associated with physiological changes and prospective research investigating how such age-related physiological changes affect clinical performance, including crisis resource management (CRM) skills, is lacking. There is a gap in the literature on whether physician's age influences baseline CRM performance and also learning from simulation. We aim to investigate whether ageing is associated with baseline CRM skills of ACPs (emergency, critical care and anaesthesia) using simulated crisis scenarios and to assess whether ageing influences learning from simulation-based education...
April 21, 2018: BMJ Open
https://www.readbyqxmd.com/read/29680141/-beneficence-and-nonmaleficence-in-care
#11
Isabelle Pipien
Is a medical decision rationally founded on the application of statistically efficient evidence-based medicine procedures fair and right for any given patient? Medical ethics invite us to consider the caregiving action through the prism of guidelines based on autonomy, beneficence/nonmaleficence and justice.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29680139/-trust-in-the-care-relationship
#12
Patrick Sureau
A relationship of trust is an expression often used by caregivers, to such an extent that it almost seems self-evident. It is nevertheless important to give some thought to this aspect in order to construct a reliable, authentic and ethical care relationship. Indeed, trust is not automatic. It requires reciprocity, a deliberate choice on the part of the caregiver and the patient.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29680138/-quality-an-ethical-dimension-in-nursing-care
#13
Philippe Svandra
Care cannot simply be summed up as a standardised practice. It constitutes an ethical obligation which drives us to respond actively to the call for help from a person suffering and in need. A real call to action, this practice, both relational and technical, strives to care about others, first and foremost in terms of their ability to be in the world.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29680132/-vulnerabilities-and-humanity-of-care-the-ethical-compass
#14
Marie-Claude Vallejo
Talking about care refers us directly to the values which shape it. At a time when these values are under threat, it is the very idea of caring which is in danger. Its moral and ethical foundations must be reasserted.
April 2018: Soins; la Revue de Référence Infirmière
https://www.readbyqxmd.com/read/29679443/a-20-year-review-the-use-of-exception-from-informed-consent-and-waiver-of-informed-consent-in-emergency-research
#15
Lauren Klein, Johanna Moore, Michelle Biros
BACKGROUND: Due to the acuity and time sensitive needs of their clinical condition, patients presenting with certain emergent pathologies may lack capacity to provide meaningful prospective informed consent to participate in clinical research. For these reasons, these populations have often been excluded from research investigations. To mitigate this, regulations allowing Exception from Informed Consent (EFIC) (21 CFR 50.24) or Waiver of Informed Consent (WIC) (45 CFR 46.101) were developed in 1996...
April 21, 2018: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/29678995/intermittent-versus-continuous-oxygen-saturation-monitoring-for-infants-hospitalised-with-bronchiolitis-study-protocol-for-a-pragmatic-randomised-controlled-trial
#16
Sanjay Mahant, Gita Wahi, Lucy Giglia, Catherine Pound, Ronik Kanani, Ann Bayliss, Madan Roy, Mahmoud Sakran, Natascha Kozlowski, Karen Breen-Reid, Mollie Lavigne, Laila Premji, Myla E Moretti, Andrew R Willan, Suzanne Schuh, Patricia C Parkin
INTRODUCTION: Bronchiolitis is the most common reason for hospitalisation in infants in developed countries. The main focus of hospital care is on supportive care, such as monitoring for hypoxia and supplemental oxygen administration, as active therapies lack effectiveness. Pulse oximetry is used to monitor hypoxia in hospitalised infants and is used either intermittently or continuously. Observational studies have suggested that continuous pulse oximetry use leads to a longer length of hospital stay in stable infants...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678987/protocol-for-a-phase-iii-non-inferiority-randomised-comparison-of-a-new-fibrinogen-concentrate-versus-cryoprecipitate-for-treating-acquired-hypofibrinogenaemia-in-bleeding-cardiac-surgical-patients-the-fibres-trial
#17
Keyvan Karkouti, Jeannie Callum, Vivek Rao, Nancy Heddle, Michael E Farkouh, Mark A Crowther, Damon C Scales
INTRODUCTION: Coagulopathic bleeding is a serious complication of cardiac surgery to which an important contributor is acquired hypofibrinogenaemia (plasma fibrinogen <1.5-2.0 g/L). The standard intervention for acquired hypofibrinogenaemia is cryoprecipitate, but purified fibrinogen concentrates are also available. There is little comparative data between the two therapies and randomised trials are needed. METHODS AND ANALYSIS: FIBrinogen REplenishment in Surgery (FIBRES) is a multicentre, randomised (1:1), active-control, single-blinded, phase III trial in adult cardiac surgical patients experiencing clinically significant bleeding related to acquired hypofibrinogenaemia...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678985/impact-of-tailored-falls-prevention-education-for-older-adults-at-hospital-discharge-on-engagement-in-falls-prevention-strategies-postdischarge-protocol-for-a-process-evaluation
#18
Chiara Naseri, Steven M McPhail, Julie Netto, Terrence P Haines, Meg E Morris, Christopher Etherton-Beer, Leon Flicker, Den-Ching A Lee, Jacqueline Francis-Coad, Anne-Marie Hill
INTRODUCTION: Older adults recently discharged from hospital have greater incidence of adverse events, functional decline, falls and subsequent readmission. Providing education to hospitalised patients on how to prevent falls at home could reduce postdischarge falls. There has been limited research investigating how older adults respond to tailored falls prevention education provided at hospital discharge. The aim of this study is to evaluate how providing tailored falls prevention education to older patients at the point of, and immediately after hospital discharge in addition to usual care, affects engagement in falls prevention strategies in the 6-months postdischarge period, including their capability and motivation to engage in falls prevention strategies...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678967/development-and-evaluation-of-an-algorithm-based-tool-for-medication-management-in-nursing-homes-the-amber-study-protocol
#19
Susanne Erzkamp, Olaf Rose
BACKGROUND: Residents of nursing homes are susceptible to risks from medication. Medication Reviews (MR) can increase clinical outcomes and the quality of medication therapy. Limited resources and barriers between healthcare practitioners are potential obstructions to performing MR in nursing homes. Focusing on frequent and relevant problems can support pharmacists in the provision of pharmaceutical care services. This study aims to develop and evaluate an algorithm-based tool that facilitates the provision of Medication Management in clinical practice...
April 20, 2018: BMJ Open
https://www.readbyqxmd.com/read/29678866/gaps-in-guidelines-for-the-management-of-diabetes-in-low-and-middle-income-versus-high-income-countries-a-systematic-review
#20
REVIEW
Mayowa O Owolabi, Joseph O Yaria, Meena Daivadanam, Akintomiwa I Makanjuola, Gary Parker, Brian Oldenburg, Rajesh Vedanthan, Shane Norris, Ayodele R Oguntoye, Morenike A Osundina, Omarys Herasme, Sulaiman Lakoh, Luqman O Ogunjimi, Sarah E Abraham, Paul Olowoyo, Carolyn Jenkins, Wuwei Feng, Hernán Bayona, Sailesh Mohan, Rohina Joshi, Ruth Webster, Andre P Kengne, Antigona Trofor, Lucia Maria Lotrean, Devarsetty Praveen, Jessica H Zafra-Tanaka, Maria Lazo-Porras, Kirsten Bobrow, Michaela A Riddell, Konstantinos Makrilakis, Yannis Manios, Bruce Ovbiagele
OBJECTIVE: The extent to which diabetes (DM) practice guidelines, often based on evidence from high-income countries (HIC), can be implemented to improve outcomes in low- and middle-income countries (LMIC) is a critical challenge. We carried out a systematic review to compare type 2 DM guidelines in individual LMIC versus HIC over the past decade to identify aspects that could be improved to facilitate implementation. RESEARCH DESIGN AND METHODS: Eligible guidelines were sought from online databases and websites of diabetes associations and ministries of health...
May 2018: Diabetes Care
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