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https://www.readbyqxmd.com/read/28549110/thoracic-aortitis-and-aortic-dissection-following-pegfilgrastim-administration
#1
Yuki Sato, Shuichiro Kaji, Hiroyuki Ueda, Keisuke Tomii
The patient was a 67-year-old woman with a history of advanced lung adenocarcinoma. Eight days after pegfilgrastim administration, her computed tomography scan revealed thickened bilateral common carotid arteries and thoracic aorta, which led to the diagnosis of pegfilgrastim-associated aortitis. Thirty-six days after pegfilgrastim administration, asymptomatic Stanford type B aortic dissection was detected. Her serum biomarker analysis suggested that interleukin-6 might be involved in the pathogenesis. Physicians should be aware of these adverse effects of filgrastim...
May 26, 2017: European Journal of Cardio-thoracic Surgery
https://www.readbyqxmd.com/read/28549003/noninvasive-thermometry-in-high-intensity-focused-ultrasound-ablation
#2
Yufeng Zhou
High-intensity focused ultrasound (HIFU) is emerging as an effective and promising treatment modality for the formation of coagulative necrosis inside the cancer/tumor noninvasively. To guarantee the efficacy and efficiency of HIFU ablation, the temperature field and consequent thermal dose should be monitored accurately in a high temporal and spatial resolution in real time. However, because of the significant variations of the tissue properties and deep penetration of HIFU beam, especially in the abdominal application, noninvasive thermometry is a very challenging topic, which may hamper the wide acceptance of HIFU by physicians worldwide...
May 25, 2017: Ultrasound Quarterly
https://www.readbyqxmd.com/read/28548896/implementation-of-asthma-clinical-practice-guidelines-in-primary-care-a-cross-sectional-study-based-on-the-knowledge-to-action-cycle
#3
Myriam E Gagné, Louis-Philippe Boulet
OBJECTIVE: Based on the Knowledge-to-Action Cycle, we assessed the self-reported implementation and perception of asthma clinical practice guideline (CPG) recommendations in primary care physicians (PCPs), along with the barriers and facilitators to CPG use in primary care. METHODS: We conducted a cross-sectional study. Using the extended Asthma Physicians' Practice Assessment Questionnaire(©), PCPs self-reported the following: their knowledge of 15 key asthma CPG recommendations, the perceived usefulness of each of these recommendations, their motivation to apply these recommendations, and their agreement with the content of these recommendations...
May 26, 2017: Journal of Asthma: Official Journal of the Association for the Care of Asthma
https://www.readbyqxmd.com/read/28548676/the-diagnosis-and-management-of-chronic-migraine-in-primary-care
#4
Werner J Becker
BACKGROUND: Chronic migraine is common, affecting approximately 1% of the general population, and causes significant disability. OBJECTIVE: To summarize optimal involvement of primary care physicians in chronic migraine care, and to provide algorithms to assist them in the diagnosis and management of patients with chronic migraine. METHODS: An analysis of diagnostic and treatment needs in chronic migraine, based on a synthesis of the medical literature and clinical experience...
May 26, 2017: Headache
https://www.readbyqxmd.com/read/28548608/a-descriptive-review-of-additional-risk-minimisation-measures-applied-to-eu-centrally-authorised-medicines-2006-2015
#5
Annalisa Rubino, Esther Artime
BACKGROUND: Guidance on therapeutic risk management, first released in EU in 2005, was updated in 2012-2013 with increased requirements on additional risk minimisation measures (aRMM). This study describes aRMM imposed at initial EU central marketing authorisation of medicines in 2006-2015. METHODS: Non-generic medicines authorised between 01/01/2006 and 31/12/2015 were identified in the European Public Assessment Report (EPAR) database. Data on aRMM, including effectiveness measures were extracted, tabulated and analysed with Excel 2016 for chi-square p value estimates and linear regression modelling as appropriate...
May 26, 2017: Expert Opinion on Drug Safety
https://www.readbyqxmd.com/read/28548220/bedside-ultrasound-in-acute-appendicitis-in-the-emergency-department-methodological-and-statistical-issues-on-diagnostic-value
#6
Fatemeh Koohi, Siamak Sabour
We were interested to read the recent paper by Gungor F and colleagues published in May issue of the Acad Emerg Med 2017.(1) The aim of the authors was to evaluate diagnostic value of point-of-care US (POCUS) in clinical decision making of emergency physicians (EPs) for acute appendicitis (AA) in the emergency department (ED).(1) A total of 264 patients were included into a prospective observational clinical study and based on their results 169 (64%) had a diagnosis of AA. This article is protected by copyright...
May 26, 2017: Academic Emergency Medicine: Official Journal of the Society for Academic Emergency Medicine
https://www.readbyqxmd.com/read/28548202/-what-can-the-provider-s-register-tell-us-about-physicians
#7
Karla Moscoso-Matus, Marco Cornejo-Ovalle, Mario Flores Ferretto
No abstract text is available yet for this article.
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28548196/-declaration-of-the-chilean-academy-of-medicine-of-law-20-850-%C3%A2-on-clinical-trials-of-pharmaceutical-products-and-medical-devices%C3%A2-and-of-the-bylaw-that-will-regulate-its-application
#8
Gloria López S, Gloria Valdés S, Emilio Roessler B, Vicente Valdivieso D
In Chile, high cost treatments required by selected medical conditions are financed by the State, according to Law 20.850. A bylaw under discussion by the Senate regulates clinical trials, posing complex issues that will endanger local interest in front-line research: 1. The exclusive and mandatory control bestowed to the Institute of Public Health during all stages of the trials and also the surveillance of institutions performing clinical trials, overriding their Clinical Research Review Boards; 2.The 10 year period during which any adverse event is assumed to have been caused by the medication or devise evaluated by the trial, unless the contrary is proven in a judicial process; 3...
March 2017: Revista Médica de Chile
https://www.readbyqxmd.com/read/28548107/current-controversies-in-brain-death-determination
#9
REVIEW
Ariane Lewis, David Greer
Although the concept of brain death is accepted by the majority of physicians, lawyers, ethicists and society at large, controversies about determination of death by neurological criteria persist, and often reach the public eye. In this article, we examine four prominent controversial brain death cases from 2013-2016. We review current controversies, including protocol variability, recognition of the American Academy of Neurology (AAN) criteria for brain death as an accepted medical standard, and management of objections to discontinuation of organ support after determination of brain death...
May 26, 2017: Nature Reviews. Neurology
https://www.readbyqxmd.com/read/28548005/geographic-variation-in-diagnostic-ability-and-quality-of-care-metrics-a-case-study-of-ankylosing-spondylitis-and-low-back-pain
#10
Jason Shafrin, Jenny Griffith, Jin Joo Shim, Caroline Huber, Arijit Ganguli, Wade Aubry
Studies examining geographic variation in care for low back pain often focus on process and outcome measures conditional on patient diagnosis but generally do not take into account a physician's ability to diagnose the root cause of low back pain. In our case study, we used increased detection of ankylosing spondylitis-a relatively rare inflammatory back disease-as a proxy for diagnostic ability and measured the relationship between ankylosing spondylitis detection, potentially inappropriate low back pain care, and cost...
January 1, 2017: Inquiry: a Journal of Medical Care Organization, Provision and Financing
https://www.readbyqxmd.com/read/28548001/the-psychiatric-morbidity-of-women-who-give-birth-to-children-with-fetal-alcohol-spectrum-disorder-fasd-results-of-the-manitoba-mothers-and-fasd-study
#11
Deepa Singal, Marni Brownell, Dan Chateau, Ana Hanlon-Dearman, Sally Longstaffe, Leslie L Roos
OBJECTIVE: To investigate differences in physician-diagnosed psychiatric disorders between women who gave birth to children with a fetal alcohol spectrum disorder (FASD) diagnosis (study group) compared to women who gave birth to children without FASD (comparison group). METHODS: We linked population-level health and social services data to clinical data on FASD diagnoses to identify study group ( n = 702) and comparison group ( n = 2097) women matched 1:3 on date of birth of index child, region of residence, and socioeconomic status...
January 1, 2017: Canadian Journal of Psychiatry. Revue Canadienne de Psychiatrie
https://www.readbyqxmd.com/read/28547948/cytokeratin-18-in-diagnosis-of-hcc-in-patients-with-liver-cirrhosis
#12
Saber A Ismail, Sherif El Saadany, Dina H Ziada, Soha S Zakaria, Wael W Mayah, Heba Elashry, Mona Arafa, Nehal Elmashad
Background: Hepatocellular carcinoma (HCC) is a common malignancy that occurs secondary to viral hepatitis B and C cirrhosis under the influence of environmental factors. In early stages, clinical diagnosis is often difficult and distinguishing HCC from cirrhosis and other hepatic masses by conventional tests is frequently not feasible. Physicians usually depend on measuring serum alpha-fetoprotein (AFP), but this marker has low sensitivity and specificity. The aim of this research was to determine any role of serum cytokeratin-18(Ck-18) as a marker for diagnosis of HCC in patients with liver cirrhosis...
April 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28547655/sexual-health-needs-and-educational-intervention-preferences-for-women-with-cancer
#13
Cara Stabile, Shari Goldfarb, Raymond E Baser, Deborah J Goldfrank, Nadeem R Abu-Rustum, Richard R Barakat, Maura N Dickler, Jeanne Carter
PURPOSE: To assess sexual/vaginal health issues and educational intervention preferences in women with a history of breast or gynecologic cancer. METHODS: Patients/survivors completed a cross-sectional survey at their outpatient visits. Main outcome measures were sexual dysfunction prevalence, type of sexual/vaginal issues, awareness of treatments, and preferred intervention modalities. Descriptive frequencies were performed, and results were dichotomized by age, treatment status, and disease site...
May 25, 2017: Breast Cancer Research and Treatment
https://www.readbyqxmd.com/read/28547563/poor-adherence-to-national-clinical-management-guidelines-a-population-based-cross-sectional-study-of-the-surgical-management-of-melanoma-in-new-south-wales-australia
#14
Alexander H R Varey, Christine M Madronio, Anne E Cust, Chris Goumas, Graham J Mann, Bruce K Armstrong, Richard A Scolyer, Austin M Curtin, John F Thompson
BACKGROUND: Standardization of the clinical management of melanoma through the formulation of national guidelines, based on interpretation of the existing evidence and consensus expert opinion, seeks to improve quality of care; however, adherence to national guidelines has not been well studied. METHODS: A population-based, cross-sectional study of the clinical management of all patients with newly notified primary melanomas in the state of New South Wales, Australia, during 2006/2007 was conducted using cancer registry identification and questionnaires completed by treating physicians...
May 25, 2017: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28547318/a-systematic-review-of-alpha-2-agonists-for-sedation-in-mechanically-ventilated-neurocritical-care-patients
#15
Alexandre Tran, Henrietta Blinder, Brian Hutton, Shane W English
The use of sedative medications is commonplace in intensive care units (ICUs) and an invaluable clinical tool for the intensive care physician. Sedation for critically ill, mechanically ventilated patients provides an opportunity to reduce anxiety, discomfort as well as ventilator intolerance and dyssynchrony. Alpha-2 agonists in particular have become increasingly popular for use in the neurocritical care population due to their proposed effectiveness in facilitating examinations and procedures as well as reducing the need for adjunctive agents...
May 25, 2017: Neurocritical Care
https://www.readbyqxmd.com/read/28547268/primary-care-providers-experience-management-and-referral-patterns-regarding-pelvic-floor-disorders-a-national-survey
#16
Donna Mazloomdoost, Catrina C Crisp, Steven D Kleeman, Rachel N Pauls
INTRODUCTION AND HYPOTHESIS: Primary care physicians can impact womens' access to care. We assessed primary care providers' experience and management regarding pelvic floor disorders. METHODS: This Institutional Review Board approved study invited internal and family Medicine Program Directors to complete and distribute to faculty an online survey designed to query demographics, perceptions, management, and referral patterns regarding urinary incontinence (UI), overactive bladder (OAB), and pelvic organ prolapse (POP) in females...
May 25, 2017: International Urogynecology Journal
https://www.readbyqxmd.com/read/28547177/guideline-for-pet-ct-imaging-of-neuroendocrine-neoplasms-with-68-ga-dota-conjugated-somatostatin-receptor-targeting-peptides-and-18-f-dopa
#17
Murat Fani Bozkurt, Irene Virgolini, Sona Balogova, Mohsen Beheshti, Domenico Rubello, Clemens Decristoforo, Valentina Ambrosini, Andreas Kjaer, Roberto Delgado-Bolton, Jolanta Kunikowska, Wim J G Oyen, Arturo Chiti, Francesco Giammarile, Stefano Fanti
PURPOSE & METHODS: Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline is aimed to assist nuclear medicine physicians in recommending, performing, reporting and interpreting the results of somatostatin receptor (SSTR) PET/CT imaging using (68)Ga-DOTA-conjugated peptides, as well as (18)F-DOPA imaging for various neuroendocrine neoplasms...
May 25, 2017: European Journal of Nuclear Medicine and Molecular Imaging
https://www.readbyqxmd.com/read/28547097/patient-completed-or-symptom-based-screening-tools-for-endometriosis-a-scoping-review
#18
REVIEW
Eric Surrey, Cathryn M Carter, Ahmed M Soliman, Shahnaz Khan, Dana B DiBenedetti, Michael C Snabes
PURPOSE: The objective of this review was to evaluate existing patient-completed screening questionnaires and/or symptom-based predictive models with respect to their potential for use as screening tools for endometriosis in adult women. Validated instruments were of particular interest. METHODS: We conducted structured searches of PubMed and targeted searches of the gray literature to identify studies reporting on screening instruments used in endometriosis. Studies were screened according to inclusion and exclusion criteria that followed the PICOS (population, intervention, comparison, outcomes, study design) framework...
May 25, 2017: Archives of Gynecology and Obstetrics
https://www.readbyqxmd.com/read/28546997/pharmacogenomic-findings-from-clinical-whole-exome-sequencing-of-diagnostic-odyssey-patients
#19
Margot A Cousin, Eric T Matey, Patrick R Blackburn, Nicole J Boczek, Tammy M McAllister, Teresa M Kruisselbrink, Dusica Babovic-Vuksanovic, Konstantinos N Lazaridis, Eric W Klee
BACKGROUND: We characterized the pharmacogenomics (PGx) results received by diagnostic odyssey patients as secondary findings during clinical whole exome sequencing (WES) testing as a part of their care in Mayo Clinic's Individualized Medicine Clinic to determine the potential benefits and limitations to this cohort. METHODS: WES results on 94 patients included a subset of PGx variants in CYP2C19,CYP2C9, and VKORC1 if identified in the patient. Demographic, phenotypic, and medication usage information was abstracted from patient medical data...
May 2017: Molecular Genetics & Genomic Medicine
https://www.readbyqxmd.com/read/28546875/spinal-cord-infarct-caused-from-suspected-fibrocartilaginous-embolism
#20
Ayham M Alkhachroum, Danielle Weiss, Alan Lerner, Michael A De Georgia
INTRODUCTION: We report a case of spinal cord infarct as a result of suspected fibrocartilaginous embolism (FCE). CASE PRESENTATION: A 23-year-old man presented with sudden onset cervical and upper back pain followed by progressive weakness in his extremities after throwing a baseball. History, neurologic examination and spinal cord imaging were consistent with spinal cord infarct. We believe the cause was from FCE. DISCUSSION: Though rare, physicians should be familiar with this diagnosis and the proposed mechanisms...
2017: Spinal Cord Series and Cases
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