keyword
https://read.qxmd.com/read/38460441/skin-perfusion-and-oxygen-saturation-after-mastectomy-and-radiation-therapy-in-breast-cancer-patients
#1
JOURNAL ARTICLE
Sherif Elawa, Ingemar Fredriksson, Ingrid Steinvall, Johan Zötterman, Simon Farnebo, Erik Tesselaar
The pathophysiological mechanism behind complications associated with postmastectomy radiotherapy (PMRT) and subsequent implant-based breast reconstruction are not completely understood. The aim of this study was to examine if there is a relationship between PMRT and microvascular perfusion and saturation in the skin after mastectomy and assess if there is impaired responsiveness to a topically applied vasodilator (Methyl nicotinate - MN). Skin microvascular perfusion and oxygenation >2 years after PMRT were measured using white light diffuse reflectance spectroscopy (DRS) and laser Doppler flowmetry (LDF) in the irradiated chest wall of 31 women with the contralateral breast as a control...
March 6, 2024: Breast: Official Journal of the European Society of Mastology
https://read.qxmd.com/read/38292934/am-i-big-boned-bone-length-scaled-reference-data-for-hrpqct-measures-of-the-radial-and-tibial-diaphysis-in-white-adults
#2
JOURNAL ARTICLE
Stuart J Warden, Robyn K Fuchs, Ziyue Liu, Katelynn R Toloday, Rachel Surowiec, Sharon M Moe
Cross-sectional size of a long bone shaft influences its mechanical properties. We recently used high-resolution peripheral quantitative computed tomography (HRpQCT) to create reference data for size measures of the radial and tibial diaphyses. However, data did not take into account the impact of bone length. Human bone exhibits relatively isometric allometry whereby cross-sectional area increases proportionally with bone length. The consequence is that taller than average individuals will generally have larger z-scores for bone size outcomes when length is not considered...
March 2024: Bone Reports
https://read.qxmd.com/read/38042835/extreme-deviations-from-the-normative-model-reveal-cortical-heterogeneity-and-associations-with-negative-symptom-severity-in-first-episode-psychosis-from-the-optimise-and-gap-studies
#3
JOURNAL ARTICLE
Amanda Worker, Pierre Berthert, Andrew J Lawrence, Seyed Mostafa Kia, Celso Arango, Richard Dinga, Silvana Galderisi, Birte Glenthøj, René S Kahn, Anoushka Leslie, Robin M Murray, Carmine M Pariante, Christos Pantelis, Mark Weiser, Inge Winter-van Rossum, Philip McGuire, Paola Dazzan, Andre F Marquand
There is currently no quantifiable method to predict long-term clinical outcomes in patients presenting with a first episode of psychosis. A major barrier to developing useful markers for this is biological heterogeneity, where many different pathological mechanisms may underly the same set of symptoms in different individuals. Normative modelling has been used to quantify this heterogeneity in established psychotic disorders by identifying regions of the cortex which are thinner than expected based on a normative healthy population range...
December 2, 2023: Translational Psychiatry
https://read.qxmd.com/read/37975431/piloting-building-early-sentences-therapy-for-pre-school-children-with-low-language-abilities-an-examination-of-efficacy-and-the-role-of-sign-as-an-active-ingredient
#4
JOURNAL ARTICLE
Anastasia Trebacz, Cristina McKean, Helen Stringer, Sean Pert
BACKGROUND: Early intervention is recommended for pre-school children with low language. However, few robustly evaluated language interventions for young children exist. Furthermore, in many interventions the theoretical underpinnings are underspecified and the 'active ingredients' of the interventions not tested. This paper presents a quasi-experimental study to test the efficacy and examine the active ingredients of Building Early Sentences Therapy (BEST): an intervention based on usage-based theory designed to support young children to understand and produce two-, three- and four-clause element sentences...
November 17, 2023: International Journal of Language & Communication Disorders
https://read.qxmd.com/read/37810933/the-relationship-between-obesity-related-h19dmr-methylation-and-h19-and-igf2-gene-expression-on-offspring-growth-and-body-composition
#5
JOURNAL ARTICLE
Perla Pizzi Argentato, Jorge Augusto Petroli Marchesi, Naiara Naiana Dejani, Patrícia Yury Nakandakare, Laísla de França da Silva Teles, Lívia Patrícia Rodrigues Batista, Maria Paula Carvalho Leitão, Liania Alves Luzia, Ester Silveira Ramos, Patricia Helen Rondó
BACKGROUND AND OBJECTIVE: Imprinted genes are important for the offspring development. To assess the relationship between obesity-related H19DMR methylation and H19 and IGF2 gene expression and offspring growth and body composition. METHODS: Thirty-nine overweight/obese and 25 normal weight pregnant women were selected from the "Araraquara Cohort Study" according to their pre-pregnancy BMI. Fetal growth and body composition and newborn growth were assessed, respectively, by ultrasound and anthropometry...
2023: Frontiers in Nutrition
https://read.qxmd.com/read/37751944/potential-benefits-of-prenatal-diagnosis-of-tga-in-australia-may-be-outweighed-by-the-adverse-effects-of-earlier-delivery-likely-causation-and-potential-solutions
#6
JOURNAL ARTICLE
Siva P Namachivayam, Warwick Butt, Christian Brizard, Johnny Millar, Jenny Thompson, Susan P Walker, Michael M H Cheung
OBJECTIVE: Prenatal diagnosis of transposition of great arteries (TGA) is expected to improve postoperative outcomes after neonatal arterial switch operation (ASO); however, published reports give conflicting results. We aimed to determine the association between prenatal diagnosis and early postoperative outcomes after neonatal ASO. METHODS: Cohort study involving 243 newborns who underwent ASO (70% prenatally diagnosed) between 2010 and 2019. Multivariable regression was used to determine the association between prenatal diagnosis and (a) birth characteristics and (b) postoperative outcomes...
September 26, 2023: Archives of Disease in Childhood
https://read.qxmd.com/read/37637355/a-clinical-score-for-quantifying-edema-in-mechanically-ventilated-children-with-congenital-heart-disease-in-intensive-care
#7
JOURNAL ARTICLE
Ben Gelbart, Sudeep Kumar Kapalavai, Vanessa Marchesini, Jeffrey Presneill, Andrea Veysey, Alyssa Serratore, Jessica Appleyard, Rinaldo Bellomo, Warwick Butt, Trevor Duke
UNLABELLED: Standardized clinical measurements of edema do not exist. OBJECTIVES: To describe a 19-point clinical edema score (CES), investigate its interobserver agreement, and compare changes between such CES and body weight. DESIGN SETTING AND PARTICIPANTS: Prospective observational study in a tertiary PICU of mechanically ventilated children with congenital heart disease. MAIN OUTCOMES AND MEASURES: Differences in the median CES between observer groups...
June 2023: Critical care explorations
https://read.qxmd.com/read/37413694/dynamic-ventilatory-reserve-during-incremental-exercise-reference-values-and-clinical-validation-in-chronic-obstructive-pulmonary-disease
#8
JOURNAL ARTICLE
Danilo C Berton, Franciele Plachi, Matthew D James, Sandra G Vincent, Reginald M Smyth, Nicolle J Domnik, Devin B Phillips, Juan P de-Torres, Luiz E Nery, Denis E O'Donnell, J Alberto Neder
Rationale: Ventilatory demand-capacity imbalance, as inferred based on a low ventilatory reserve, is currently assessed only at peak cardiopulmonary exercise testing (CPET). Peak ventilatory reserve, however, is poorly sensitive to the submaximal, dynamic mechanical ventilatory abnormalities that are key to dyspnea genesis and exercise intolerance. Objectives: After establishing sex- and age-corrected norms for dynamic ventilatory reserve at progressively higher work rates, we compared peak and dynamic ventilatory reserve for their ability to expose increased exertional dyspnea and poor exercise tolerance in mild to very severe chronic obstructive pulmonary disease (COPD)...
October 2023: Annals of the American Thoracic Society
https://read.qxmd.com/read/37313241/the-clinical-septet-of-van-wyk-grumbach-syndrome-a-case-series-from-a-tertiary-care-centre-in-kalyana-karnataka-india
#9
Swaraj Waddankeri, Meenakshi Waddankeri, Shrikant Waddankeri, Kshitij Arora
Van Wyk-Grumbach syndrome is a rare, female juvenile hypothyroidism disorder that is characterized by precocious puberty with clinical, radiological and hormonal pathologies. We present a case series of three patients with this unusual condition who were evaluated and followed up over a 3-year period between January 2017 and June 2020. All three patients presented with short stature (<3rd centile), low weight (<3rd centile), absence of goitre, no axillary or pubic hair, delayed bone age by more than 2 years, elevated thyroid-stimulating hormone with low T3 and T4 (primary hypothyroidism), and raised follicle-stimulating hormone with pre-pubertal levels of luteinizing hormone...
May 2023: TouchREVIEWS in endocrinology
https://read.qxmd.com/read/36967048/sex-and-age-differences-in-the-association-between-high-sensitivity-c-reactive-protein-and-all-cause-mortality-a-12-year-prospective-cohort-study
#10
JOURNAL ARTICLE
Solim Essomandan Clémence Bafei, Song Yang, Changying Chen, Xincheng Gu, Jialing Mu, Fangyuan Liu, Junxiang Sun, Qian Zhuang, Pengfei Wei, Xianghai Zhao, Yanchun Chen, Yunjie Yin, Hankun Xie, Chong Shen
To explore the influence of age on hs-CRP among men and women and investigate the impact of hs-CRP on all-cause death, this prospective cohort enrolled 4128 community adults from 2009 to 2022 for all-cause death. Age and sex-specific hs-CRP percentile curves were generated using the GAMLSS method. Cox-proportional hazard regression analysis was applied to estimate the hazard ratios (HRs) and 95 % confidence intervals (CIs). During the follow-up with a median of 12.59 years, 701 cases of all-cause death were identified...
April 2023: Mechanisms of Ageing and Development
https://read.qxmd.com/read/36864542/management-of-late-onset-fetal-growth-restriction-pragmatic-approach
#11
JOURNAL ARTICLE
R Peasley, L A Abrego Rangel, D Casagrandi, V Donadono, M Willinger, G Conti, Y Seminara, N Marlow, A L David, G Attilakos, P Pandya, A Zaikin, D Peebles, R Napolitano
OBJECTIVES: There is limited prospective evidence to guide the management of late-onset fetal growth restriction (FGR) and its differentiation from small-for-gestational age. The aim of this study was to assess prospectively a novel protocol in which ultrasound criteria were used to classify women with suspected late FGR into two groups: those at low risk, who were managed expectantly until the anticipated date of delivery, and those at high risk, who were delivered soon after 37 weeks of gestation...
July 2023: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/36837853/placental-metabolomics-of-fetal-growth-restriction
#12
JOURNAL ARTICLE
Jacopo Troisi, Steven J K Symes, Martina Lombardi, Pierpaolo Cavallo, Angelo Colucci, Giovanni Scala, David C Adair, Maurizio Guida, Sean M Richards
Fetal growth restriction is an obstetrical pathological condition that causes high neonatal mortality and morbidity. The mechanisms of its onset are not completely understood. Metabolites were extracted from 493 placentas from non-complicated pregnancies in Hamilton Country, TN (USA), and analyzed by gas chromatography-mass spectrometry (GC-MS). Newborns were classified according to raw fetal weight (low birth weight (LBW; <2500 g) and non-low birth weight (Non-LBW; >2500 g)), and according to the calculated birth weight centile as it relates to gestational age (small for gestational age (SGA), large for gestational age (LGA), and adequate for gestational age (AGA))...
February 4, 2023: Metabolites
https://read.qxmd.com/read/36329553/genistein-effect-on-cognition-in-prodromal-alzheimer-s-disease-patients-the-genial-clinical-trial
#13
RANDOMIZED CONTROLLED TRIAL
José Viña, Joaquín Escudero, Miquel Baquero, Mónica Cebrián, Juan Antonio Carbonell-Asíns, José Enrique Muñoz, Encarnación Satorres, Juan Carlos Meléndez, José Ferrer-Rebolleda, Mª Del Puig Cózar-Santiago, Jose Manuel Santabárbara-Gómez, Mariona Jové, Reinald Pamplona, Francisco José Tarazona-Santabalbina, Consuelo Borrás
BACKGROUND: Delaying the transition from minimal cognitive impairment to Alzheimer's dementia is a major concern in Alzheimer's disease (AD) therapeutics. Pathological signs of AD occur years before the onset of clinical dementia. Thus, long-term therapeutic approaches, with safe, minimally invasive, and yet effective substances are recommended. There is a need to develop new drugs to delay Alzheimer's dementia. We have taken a nutritional supplement approach with genistein, a chemically defined polyphenol that acts by multimodal specific mechanisms...
November 4, 2022: Alzheimer's Research & Therapy
https://read.qxmd.com/read/36275827/gestational-weight-gain-in-the-revamp-pregnancy-cohort-in-western-india-comparison-with-international-and-national-references
#14
JOURNAL ARTICLE
Kamini Dangat, Sanjay Gupte, Girija Wagh, Sanjay Lalwani, Karuna Randhir, Shweta Madiwale, Hemlata Pisal, Vrushali Kadam, Shridevi Gundu, Nomita Chandhiok, Bharati Kulkarni, Sadhana Joshi, Caroline Fall, Harshpal Singh Sachdev
Objective: To determine the trimester specific gestational weight gain (GWG) in a population of pregnant women from Western India and compare it with the Intergrowth-21st international and an Indian reference (GARBH-Ini cohort-Group for Advanced Research on BirtH outcomes). Study design: A prospective longitudinal observational study was undertaken in Pune, West India and data for gestational weight gain was collected [the REVAMP study (Research Exploring Various Aspects and Mechanisms in Preeclampsia)]...
2022: Frontiers in Medicine
https://read.qxmd.com/read/35838081/growth-in-individuals-with-satb2-associated-syndrome
#15
JOURNAL ARTICLE
Yuri A Zarate, Amrit Kannan, Katherine A Bosanko, Aisling R Caffrey
SATB2-associated syndrome (SAS) is an autosomal dominant multisystemic disorder caused by alterations in the SATB2 gene. In addition to a predominant neurodevelopmental phenotype, individuals with SAS often present with feeding difficulties and growth retardation that persist past infancy. In this study, we present growth and measurement data from 211 individuals (53.6% male, 46.4% female) with SAS due to different molecular mechanisms. To delineate growth in this population, we constructed SAS-specific growth charts by sex from birth to 10 years of age...
July 15, 2022: American Journal of Medical Genetics. Part A
https://read.qxmd.com/read/35015926/fetal-neurosonography-at-31-35-weeks-reveals-altered-cortical-development-in-pre-eclampsia-with-and-without-small-for-gestational-age-fetus
#16
JOURNAL ARTICLE
A Basso, L Youssef, A Nakaki, C Paules, J Miranda, G Casu, L Salazar, E Gratacos, E Eixarch, F Crispi, F Crovetto
OBJECTIVE: To explore the pattern of fetal cortical development in pregnancies complicated by pre-eclampsia (PE), with and without a small-for-gestational-age (SGA) fetus, compared to uncomplicated pregnancies. METHODS: This was a prospective observational study including singleton pregnancies complicated by normotensive SGA (birth weight < 10th centile) (n = 77), PE with an appropriate-for-gestational-age (AGA) fetus (n = 76) or PE with a SGA fetus (n = 67), and 128 uncomplicated pregnancies (normotensive AGA) matched by gestational age at ultrasound...
June 2022: Ultrasound in Obstetrics & Gynecology
https://read.qxmd.com/read/34778865/the-income-gradient-in-covid-19-mortality-and-hospitalisation-an-observational-study-with-social-security-administrative-records-in-mexico
#17
JOURNAL ARTICLE
Eva O Arceo-Gomez, Raymundo M Campos-Vazquez, Gerardo Esquivel, Eduardo Alcaraz, Luis A Martinez, Norma G Lopez
Background: The COVID-19 pandemic revealed large structural inequalities that led to disparities in health outcomes related to socioeconomic status. So far, most of the evidence is based on aggregated data or simulations with individual data, which point to various possible mechanisms behind the association. To date, there have been no studies regarding an income gradient in COVID-19 mortality based on individual-level data and adjusting for comorbidities or access to healthcare. Methods: In this paper, we use linked employee-patient data for patients tested for COVID-19 at the Mexican Institute of Social Security...
February 2022: Lancet Reg Health Am
https://read.qxmd.com/read/34461078/circulating-maternal-placental-growth-factor-responses-to-low-molecular-weight-heparin-in-pregnant-patients-at-risk-of-placental-dysfunction
#18
JOURNAL ARTICLE
Kelsey McLaughlin, Sebastian R Hobson, Anjana Ravi Chandran, Swati Agrawal, Rory C Windrim, W Tony Parks, Adrian W Bowman, Ulla Sovio, Gordon C Smith, John C Kingdom
BACKGROUND: Patients at high risk of severe preeclampsia and fetal growth restriction have low circulating levels of placental growth factor and features of maternal vascular malperfusion placental pathology at delivery. Multimodal screening and commencement of aspirin prophylaxis at 11 to 13 weeks' gestation markedly reduces the risk of preterm delivery with preeclampsia. However, the additional role of low-molecular-weight heparin and mechanisms of action remain uncertain. Because low-molecular-weight heparin augments the production and release of placental growth factor in vitro by both placental villi and vascular endothelium, it may be effective to suppress the risk of severe preeclampsia in a niche group of high-risk patients with low circulating placental growth factor in the early second trimester...
February 2022: American Journal of Obstetrics and Gynecology
https://read.qxmd.com/read/34397395/differences-in-human-placental-mesenchymal-stromal-cells-may-impair-vascular-function-in-fgr
#19
JOURNAL ARTICLE
Anna L Boss, Lawrence W Chamley, Anna E S Brooks, Joanna L James
Placentae from pregnancies with foetal growth restriction (FGR) exhibit poor oxygen and nutrient exchange, in part due to impaired placental vascular development. Placental mesenchymal stromal cells (pMSCs) reside in a perivascular niche, where they may influence blood vessel formation/function. However, the role of pMSCs in vascular dysfunction in FGR is unclear. To elucidate the mechanisms by which pMSCs may impact placental vascularisation we compared the transcriptomes of human pMSCs isolated from FGR (<5th centile) (n = 7) and gestation-matched control placentae (n = 9) using Affymetrix microarrays...
September 8, 2021: Reproduction
https://read.qxmd.com/read/34311666/the-association-between-maternal-complications-and-small-for-gestational-age-in-twin-pregnancies-using-singleton-and-twin-birth-weight-references
#20
JOURNAL ARTICLE
Shuping Lyu, Li Gao, Jinling Sun, Xinrong Zhao, Yi Wu, Renyi Hua, Yanlin Wang
INTRODUCTION: In singleton pregnancies, maternal complications, such as preeclampsia and thyroid dysfunction are associated with small for gestational age (SGA). However, data on the association between SGA and maternal complications in twin pregnancies are limited and conflicting. Small sample size and the application of singleton birth weight reference (SBWR) to define SGA in twins may be reasons for the inconsistent conclusions. Purpose of this study was to define SGA in dichorionic diamniotic (DCDA) and monochorionic diamniotic (MCDA) twin pregnancies using both SBWR and twin birth weight reference (TBWR) and to determine whether certain maternal complications are associated with SGA in twin pregnancies...
July 26, 2021: Journal of Maternal-fetal & Neonatal Medicine
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