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ADHD Epstein Barr

Kathleen Van Craenenbroeck, Evelien Gellynck, Béatrice Lintermans, Josée E Leysen, Hubert H M Van Tol, Guy Haegeman, Peter Vanhoenacker
The dopamine D4 receptor is a G protein-coupled receptor that binds with high affinity various antipsychotics. The receptor may be involved in attention/cognition, and in genetic studies a polymorphic repeat sequence in its coding sequence has been associated with attention deficit/hyperactivity disorder. We developed an inducible episomal expression system based on the reverse tetracycline transactivator and Epstein-Barr viral sequences. In HEK293rtTA cells expressing the dopamine D4 receptor from this episomal expression vector, addition of doxycycline in combination with sodium butyrate and trichostatin A induces high levels of receptor expression, resulting in 1970 +/- 20 fmol/mg membrane protein...
December 3, 2006: Life Sciences
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