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https://www.readbyqxmd.com/read/27922747/frailty-and-subsequent-disability-and-mortality-among-patients-with-critical-illness
#1
Nathan E Brummel, Susan P Bell, Timothy D Girard, Pratik P Pandharipande, James C Jackson, Alessandro Morandi, Jennifer L Thompson, Rameela Chandrasekhar, Gordon R Bernard, Robert S Dittus, Thomas M Gill, E Wesley Ely
INTRODUCTION The prevalence of frailty (diminished physiologic reserve) and its effect on outcomes for those ≥18 years old with critical illness is unclear. We hypothesized greater frailty would be associated with subsequent mortality, disability, and cognitive impairment, regardless of age. METHODS At enrollment, we measured frailty using the Clinical Frailty Scale (CFS, range 1 [very fit] to 7 [severely frail]). At 3 and 12 months post-discharge, we assessed vital status, instrumental and basic activities of daily living (IADLs and BADLs), and cognition...
December 6, 2016: American Journal of Respiratory and Critical Care Medicine
https://www.readbyqxmd.com/read/27894380/an-attention-and-interpretation-bias-for-illness-specific-information-in-chronic-fatigue-syndrome
#2
A M Hughes, T Chalder, C R Hirsch, R Moss-Morris
BACKGROUND: Studies have shown that specific cognitions and behaviours play a role in maintaining chronic fatigue syndrome (CFS). However, little research has investigated illness-specific cognitive processing in CFS. This study investigated whether CFS participants had an attentional bias for CFS-related stimuli and a tendency to interpret ambiguous information in a somatic way. It also determined whether cognitive processing biases were associated with co-morbidity, attentional control or self-reported unhelpful cognitions and behaviours...
November 29, 2016: Psychological Medicine
https://www.readbyqxmd.com/read/27842511/comparative-assessment-of-two-frailty-instruments-for-risk-stratification-in-elderly-surgical-patients-study-protocol-for-a-prospective-cohort-study
#3
Daniel I McIsaac, Monica Taljaard, Gregory L Bryson, Paul E Beaule, Sylvain Gagne, Gavin Hamilton, Emily Hladkowicz, Allen Huang, John Joanisse, Luke T Lavallée, Hussein Moloo, Kednapa Thavorn, Carl van Walraven, Homer Yang, Alan J Forster
BACKGROUND: Frailty is an aggregate expression of susceptibility to poor outcomes, owing to age-, and disease-related deficits that accumulate within multiple domains. Older patients who are frail before surgery are at an increased risk of morbidity and mortality, and use a disproportionately high amount of healthcare resources. While frailty is now a well-established risk factor for adverse postoperative outcomes, the perioperative literature lacks studies that: 1) compare the predictive accuracy of different frailty instruments; 2) consider the impact of frailty on patient-reported outcome measures; and 3) consider the acceptability and feasibility of using frailty instruments in clinical practice...
November 14, 2016: BMC Anesthesiology
https://www.readbyqxmd.com/read/27811338/the-edss-integration-with-the-brief-international-cognitive-assessment-for-multiple-sclerosis-and-orientation-tests
#4
Francesco Saccà, Teresa Costabile, Antonio Carotenuto, Roberta Lanzillo, Marcello Moccia, Chiara Pane, Cinzia Valeria Russo, Anna Maria Barbarulo, Sara Casertano, Fabiana Rossi, Elisabetta Signoriello, Giacomo Lus, Vincenzo Brescia Morra
OBJECTIVE: Despite cognitive tests have been validated in multiple sclerosis (MS), a neuropsychological evaluation is not implemented in the Expanded Disability Status Scale (EDSS) scoring. METHODS: We used the Brief International Cognitive Assessment for Multiple Sclerosis (BICAMS) and orientation tests (OTs) to measure the cerebral functional system (CFS) score and to evaluate its impact on the EDSS. We compared EDSS calculated as usual (Native-EDSS) and after the use of the BICAMS and OT (NPS-EDSS)...
November 3, 2016: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/27742756/-it-s-personal-to-me-a-qualitative-study-of-depression-in-young-people-with-cfs-me
#5
Anna K Taylor, Maria Loades, Amberly Lc Brigden, Simon M Collin, Esther Crawley
BACKGROUND: Paediatric chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) has a prevalence of 0.4-2.4% and is defined as 'generalised disabling fatigue persisting after routine tests and investigations have failed to identify an obvious underlying cause'. One-third of young people with CFS/ME have probable depression. Little is known about why depression develops, the relationship between depression and CFS/ME, or what treatment might be helpful. METHODS: We conducted nine semi-structured interviews with young people with CFS/ME (aged 13-17 years, 8/9 female) and probable depression, covering perceived causes of depression, the relationship between CFS/ME and depression, and treatment strategies...
October 14, 2016: Clinical Child Psychology and Psychiatry
https://www.readbyqxmd.com/read/27739228/well-being-in-chronic-fatigue-syndrome-relationship-to-symptoms-and-psychological-distress
#6
H Jackson, A K MacLeod
OBJECTIVE: There is growing recognition in psychology that wellness is more than the absence of disease and distress. Well-being has been defined in numerous ways. Two dominant models include Diener, Eunkook, Suh, Lucas and Smith's (1999) model of subjective well-being (SWB) and Ryff's (1989) model of psychological well-being (PWB). In contrast to the abundance of research investigating negative constructs and psychopathology in chronic fatigue syndrome (CFS), there has been a paucity of positive psychology studies...
October 13, 2016: Clinical Psychology & Psychotherapy
https://www.readbyqxmd.com/read/27428358/neuromuscular-strain-increases-symptom-intensity-in-chronic-fatigue-syndrome
#7
Peter C Rowe, Kevin R Fontaine, Megan Lauver, Samantha E Jasion, Colleen L Marden, Malini Moni, Carol B Thompson, Richard L Violand
Chronic fatigue syndrome (CFS) is a complex, multisystem disorder that can be disabling. CFS symptoms can be provoked by increased physical or cognitive activity, and by orthostatic stress. In preliminary work, we noted that CFS symptoms also could be provoked by application of longitudinal neural and soft tissue strain to the limbs and spine of affected individuals. In this study we measured the responses to a straight leg raise neuromuscular strain maneuver in individuals with CFS and healthy controls. We randomly assigned 60 individuals with CFS and 20 healthy controls to either a 15 minute period of passive supine straight leg raise (true neuromuscular strain) or a sham straight leg raise...
2016: PloS One
https://www.readbyqxmd.com/read/27411751/cognitive-behaviour-therapy-for-chronic-fatigue-syndrome-differences-in-treatment-outcome-between-a-tertiary-treatment-centre-in-the-united-kingdom-and-the-netherlands
#8
M Worm-Smeitink, S Nikolaus, K Goldsmith, J Wiborg, S Ali, H Knoop, T Chalder
OBJECTIVE: Cognitive behaviour therapy (CBT) reduces fatigue and disability in chronic fatigue syndrome (CFS). However, outcomes vary between studies, possibly because of differences in patient characteristics, treatment protocols, diagnostic criteria and outcome measures. The objective was to compare outcomes after CBT in tertiary treatment centres in the Netherlands (NL) and the United Kingdom (UK), using different treatment protocols but identical outcome measures, while controlling for differences in patient characteristics and diagnostic criteria...
August 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27411750/complementary-and-alternative-healthcare-use-by-participants-in-the-pace-trial-of-treatments-for-chronic-fatigue-syndrome
#9
G Lewith, B Stuart, T Chalder, C McDermott, P D White
BACKGROUND: Chronic Fatigue Syndrome (CFS) is characterised by persistent fatigue, disability and a range of other symptoms. The PACE trial was randomised to compare four non-pharmacological treatments for patients with CFS in secondary care clinics. The aims of this sub study were to describe the use of complementary and alternative medicine (CAM) in the trial sample and to test whether CAM use correlated with an improved outcome. METHOD: CAM use was recorded at baseline and 52weeks...
August 2016: Journal of Psychosomatic Research
https://www.readbyqxmd.com/read/27403211/clinical-frailty-scale-in-an-acute-medicine-unit-a-simple-tool-that-predicts-length-of-stay
#10
Salina Juma, Mary-Margaret Taabazuing, Manuel Montero-Odasso
BACKGROUND: Frailty is characterized by increased vulnerability to external stressors. When frail older adults are admitted to hospital, they are at increased risk of adverse events including falls, delirium, and disability. The Clinical Frailty Scale (CFS) is a practical and efficient tool for assessing frailty; however, its ability to predict outcomes has not been well studied within the acute medical service. OBJECTIVE: To examine the CFS in elderly patients admitted to the acute medical ward and its association with length of stay...
June 2016: Canadian Geriatrics Journal: CGJ
https://www.readbyqxmd.com/read/27377634/managed-activity-graded-exercise-in-teenagers-and-pre-adolescents-magenta-feasibility-randomised-controlled-trial-study-protocol
#11
Amberly Brigden, Lucy Beasant, William Hollingworth, Chris Metcalfe, Daisy Gaunt, Nicola Mills, Russell Jago, Esther Crawley
INTRODUCTION: Paediatric chronic fatigue syndrome or myalgic encephalomyelitis (CFS/ME) is a relatively common and disabling condition, yet there is a limited evidence base for treatment. There is good evidence that graded exercise therapy is moderately effective in adults with CFS/ME, but there is little evidence for the effectiveness, cost-effectiveness, acceptability or best method of delivery for paediatric CFS/ME. This study aims to investigate the acceptability and feasibility of carrying out a multicentre randomised controlled trial investigating the effectiveness of graded exercise therapy compared with activity management for children/teenagers who are mildly or moderately affected with CFS/ME...
2016: BMJ Open
https://www.readbyqxmd.com/read/27362406/novel-characterisation-of-mast-cell-phenotypes-from-peripheral-blood-mononuclear-cells-in-chronic-fatigue-syndrome-myalgic-encephalomyelitis-patients
#12
Thao Nguyen, Samantha Johnston, Anu Chacko, Damien Gibson, Julia Cepon, Peter Smith, Donald Staines, Sonya Marshall-Gradisnik
BACKGROUND: Mast cells (MCs) mediate inflammation through neuropeptides and cytokines, along with histamine and reactive oxygen species (ROS). Chronic Fatigue Syndrome/Myalgic Encephalomyelitis (CFS/ME) is an illness characterized by an unexplained disabling fatigue with multiple physiological impairments as well as dysregulated cytokine profiles. OBJECTIVE: To determine mast cell phenotypes in isolated human PBMCs, in healthy controls and in CFS/ME patients. Second, determine receptor expression of RAGE and its ligand high mobility group box 1 protein (HMGB1)...
June 30, 2016: Asian Pacific Journal of Allergy and Immunology
https://www.readbyqxmd.com/read/27281086/in-vivo-confocal-microscopy-of-meibomian-glands-in-primary-blepharospasm-a-prospective-case-control-study-in-a-chinese-population
#13
Tong Lin, Lan Gong
The aim of the study was to evaluate the morphological changes of meibomian glands (MGs) in primary blepharospasm (PBS) by in vivo laser scanning confocal microscopy (LSCM) and to investigate the correlations between clinical data of PBS and LSCM parameters of MGs. This prospective and case-control study recruited 30 consecutive PBS patients and 30 age- and gender-matched healthy controls. After questionnaire assessments of ocular surface disease index (OSDI), Jankovic rating scale, and blepharospasm disability index, all subjects underwent blink rate evaluation, tear film break-up time (TBUT), corneal fluorescein staining (CFS), Schirmer test, MG expressibility, meibum quality, MG dropout, and LSCM examination of the MGs...
June 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27278762/graded-exercise-therapy-guided-self-help-trial-for-patients-with-chronic-fatigue-syndrome-getset-protocol-for-a-randomized-controlled-trial-and-interview-study
#14
Lucy V Clark, Paul McCrone, Damien Ridge, Anna Cheshire, Mario Vergara-Williamson, Francesca Pesola, Peter D White
BACKGROUND: Chronic fatigue syndrome, also known as myalgic encephalomyelitis (CFS/ME), is characterized by chronic disabling fatigue and other symptoms, which are not explained by an alternative diagnosis. Previous trials have suggested that graded exercise therapy (GET) is an effective and safe treatment. GET itself is therapist-intensive with limited availability. OBJECTIVE: While guided self-help based on cognitive behavior therapy appears helpful to patients, Guided graded Exercise Self-help (GES) is yet to be tested...
2016: JMIR Research Protocols
https://www.readbyqxmd.com/read/27149955/altered-neuroendocrine-control-and-association-to-clinical-symptoms-in-adolescent-chronic-fatigue-syndrome-a-cross-sectional-study
#15
Vegard Bruun Wyller, Valieria Vitelli, Dag Sulheim, Even Fagermoen, Anette Winger, Kristin Godang, Jens Bollerslev
BACKGROUND: Chronic fatigue syndrome (CFS) is a common and disabling disorder, and a major threat against adolescent health. The pathophysiology is unknown, but alteration of neuroendocrine control systems might be a central element, resulting in attenuation of the hypothalamus-pituitary-adrenalin (HPA) axis and enhancement of the sympathetic/adrenal medulla (SAM) system. This study explored differences in neuroendocrine control mechanisms between adolescent CFS patients and healthy controls, and whether characteristics of the control mechanisms are associated with important clinical variables within the CFS group...
May 5, 2016: Journal of Translational Medicine
https://www.readbyqxmd.com/read/27123773/progressive-brain-changes-in-patients-with-chronic-fatigue-syndrome-a-longitudinal-mri-study
#16
Zack Y Shan, Richard Kwiatek, Richard Burnet, Peter Del Fante, Donald R Staines, Sonya M Marshall-Gradisnik, Leighton R Barnden
PURPOSE: To examine progressive brain changes associated with chronic fatigue syndrome (CFS). MATERIALS AND METHODS: We investigated progressive brain changes with longitudinal MRI in 15 CFS and 10 normal controls (NCs) scanned twice 6 years apart on the same 1.5 Tesla (T) scanner. MR images yielded gray matter (GM) volumes, white matter (WM) volumes, and T1- and T2-weighted signal intensities (T1w and T2w). Each participant was characterized with Bell disability scores, and somatic and neurological symptom scores...
November 2016: Journal of Magnetic Resonance Imaging: JMRI
https://www.readbyqxmd.com/read/27045557/efficacy-of-rintatolimod-in-the-treatment-of-chronic-fatigue-syndrome-myalgic-encephalomyelitis-cfs-me
#17
William M Mitchell
Chronic fatigue syndrome/ Myalgic encephalomyelitis (CFS/ME) is a poorly understood seriously debilitating disorder in which disabling fatigue is an universal symptom in combination with a variety of variable symptoms. The only drug in advanced clinical development is rintatolimod, a mismatched double stranded polymer of RNA (dsRNA). Rintatolimod is a restricted Toll-Like Receptor 3 (TLR3) agonist lacking activation of other primary cellular inducers of innate immunity (e.g.- cytosolic helicases). Rintatolimod also activates interferon induced proteins that require dsRNA for activity (e...
June 2016: Expert Review of Clinical Pharmacology
https://www.readbyqxmd.com/read/26998359/understanding-muscle-dysfunction-in-chronic-fatigue-syndrome
#18
REVIEW
Gina Rutherford, Philip Manning, Julia L Newton
Introduction. Chronic fatigue syndrome/myalgic encephalomyelitis (CFS/ME) is a debilitating disorder of unknown aetiology, characterised by severe disabling fatigue in the absence of alternative diagnosis. Historically, there has been a tendency to draw psychological explanations for the origin of fatigue; however, this model is at odds with findings that fatigue and accompanying symptoms may be explained by central and peripheral pathophysiological mechanisms, including effects of the immune, oxidative, mitochondrial, and neuronal pathways...
2016: Journal of Aging Research
https://www.readbyqxmd.com/read/26810786/chronic-fatigue-syndrome-at-age-16-years
#19
Simon M Collin, Tom Norris, Roberto Nuevo, Kate Tilling, Carol Joinson, Jonathan A C Sterne, Esther Crawley
BACKGROUND: In the Avon Longitudinal Study of Parents and Children (ALSPAC) birth cohort, chronic disabling fatigue lasting ≥6 months affected 1.3% of 13-year-olds, was equally common in boys and girls, and became more prevalent with increasing family adversity. METHODS: ALSPAC data were used to estimate the prevalence of chronic fatigue syndrome (CFS) at age 16 years, defined by parental report of unexplained disabling fatigue lasting ≥6 months. We investigated gender and a composite 14-item family adversity index as risk factors...
February 2016: Pediatrics
https://www.readbyqxmd.com/read/26804593/the-role-of-the-hippocampus-in-the-pathogenesis-of-myalgic-encephalomyelitis-chronic-fatigue-syndrome-me-cfs
#20
Jean-Michel Saury
Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) is a severe acquired illness characterized by a profound sensation of fatigue, not ameliorated by rest and resulting in a substantial decrease in the amount and quality of occupational, social and recreational activities. Despite intense research, the aetiology and pathogenesis of ME/CFS is still unknown and no conclusive biological markers have been found. As a consequence, an accepted curative treatment is still lacking and rehabilitation programmes are not very effective, as few patients recover...
January 2016: Medical Hypotheses
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