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https://www.readbyqxmd.com/read/17825267/akt1-is-associated-with-schizophrenia-across-multiple-symptom-dimensions-in-the-irish-study-of-high-density-schizophrenia-families
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Dawn L Thiselton, Vladimir I Vladimirov, Po-Hsiu Kuo, Joseph McClay, Brandon Wormley, Ayman Fanous, Francis A O'Neill, Dermot Walsh, Edwin J C G Van den Oord, Kenneth S Kendler, Brien P Riley
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients. METHODS: The association of DTNBP1 in the Irish Study of High Density Schizophrenia Families (ISHDSF) prompted our investigation of AKT1 for association with disease in this sample...
March 1, 2008: Biological Psychiatry
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