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Prefrontal cortex Ireland

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https://www.readbyqxmd.com/read/29152994/decreased-connectivity-and-increased-blood-oxygenation-level-dependent-complexity-in-the-default-mode-network-in-individuals-with-chronic-fatigue-syndrome
#1
Zack Y Shan, Kevin Finegan, Sandeep Bhuta, Timothy Ireland, Donald R Staines, Sonya M Marshall-Gradisnik, Leighton R Barnden
The chronic fatigue syndrome (CFS)/myalgic encephalomyelitis is a debilitating disease with unknown pathophysiology and no diagnostic test. This study investigated the default mode network (DMN) to understand the pathophysiology of CFS and to identify potential biomarkers. Using functional MRI (fMRI) collected from 72 subjects (45 CFS and 27 controls) with a temporal resolution of 0.798 sec, we evaluated the DMN using static functional connectivity (FC), dynamic functional connectivity (DFC) and DFC complexity, blood oxygenation level dependent (BOLD) activation maps, and complexity of activity...
February 2018: Brain Connectivity
https://www.readbyqxmd.com/read/17825267/akt1-is-associated-with-schizophrenia-across-multiple-symptom-dimensions-in-the-irish-study-of-high-density-schizophrenia-families
#2
Dawn L Thiselton, Vladimir I Vladimirov, Po-Hsiu Kuo, Joseph McClay, Brandon Wormley, Ayman Fanous, Francis A O'Neill, Dermot Walsh, Edwin J C G Van den Oord, Kenneth S Kendler, Brien P Riley
BACKGROUND: The phosphatidylinositol 3-kinase (PI3K)-AKT signal transduction pathway is critical to cell growth and survival. In vitro functional studies indicate that the candidate schizophrenia susceptibility gene DTNBP1 influences AKT signaling to promote neuronal viability. The AKT1 gene has also been implicated in schizophrenia by association studies and decreased protein expression in the brains of schizophrenic patients. METHODS: The association of DTNBP1 in the Irish Study of High Density Schizophrenia Families (ISHDSF) prompted our investigation of AKT1 for association with disease in this sample...
March 1, 2008: Biological Psychiatry
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