Glenda Canderan, Lyndsey M Muehling, Alexandra Kadl, Shay Ladd, Catherine Bonham, Claire E Cross, Sierra M Lima, Xihui Yin, Jeffrey M Sturek, Jeffrey M Wilson, Behnam Keshavarz, Naomi Bryant, Deborah D Murphy, In Su Cheon, Coleen A McNamara, Jie Sun, Paul J Utz, Sepideh Dolatshahi, Jonathan M Irish, Judith A Woodfolk
The variable etiology of persistent breathlessness after COVID-19 have confounded efforts to decipher the immunopathology of lung sequelae. Here, we analyzed hundreds of cellular and molecular features in the context of discrete pulmonary phenotypes to define the systemic immune landscape of post-COVID lung disease. Cluster analysis of lung physiology measures highlighted two phenotypes of restrictive lung disease that differed by their impaired diffusion and severity of fibrosis. Machine learning revealed marked CCR5+CD95+ CD8+ T-cell perturbations in mild-to-moderate lung disease, but attenuated T-cell responses hallmarked by elevated CXCL13 in more severe disease...
April 4, 2024: bioRxiv