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https://www.readbyqxmd.com/read/28648902/self-reported-unsteadiness-predicts-fear-of-falling-activity-restriction-falls-and-disability
#1
Orna A Donoghue, Annalisa Setti, Neil O'Leary, Rose Anne Kenny
OBJECTIVE: To determine if self-reported unsteadiness during walking is associated with fear of falling (FOF), fear-related activity restriction, falls, and disability over 2 years in community-dwelling adults. DESIGN: Data were obtained from the first 2 waves of The Irish Longitudinal Study on Ageing, a population-based study. SETTING: Participants completed a home-based interview and a center-based health assessment at baseline and a home-based interview at 2 years follow-up...
July 1, 2017: Journal of the American Medical Directors Association
https://www.readbyqxmd.com/read/28645090/the-impact-of-tidal-and-mesoscale-eddy-advection-on-the-long-term-dispersion-of-99-tc-from-sellafield
#2
Magne Simonsen, Øyvind Saetra, Pål Erik Isachsen, Ole Christian Lind, Hilde Kristin Skjerdal, Brit Salbu, Hilde Elise Heldal, Justin P Gwynn
In the present work, numerical models are used to study the fate of the (99)Tc discharges from Sellafield with a specific focus on the role of mesoscale eddy and tidal advection on the transport and dispersion of this radionuclide. Transport estimates are made with an ocean model that resolves a large part of the ocean mesoscale eddy field and also includes tides. Equivalent estimates are also computed with another model in which these processes are either absent or parametrized. Comparison with field observations shows that the coarse-resolution model can reproduce the general features of the observed time-space (99)Tc distribution if the diffusivity in its eddy parametrization scheme is suitably chosen...
June 20, 2017: Journal of Environmental Radioactivity
https://www.readbyqxmd.com/read/28644590/mutyh-associated-polyposis-the-irish-experience
#3
T P McVeigh, M Duff, C Carroll, R O'Shea, L Bradley, M Farrell, D J Gallagher, C Clabby, A J Green
MUTYH is involved in DNA damage repair. Bi-allelic MUTYH mutations predispose to polyposis and gastrointestinal malignancies, distinct genetically from autosomal dominant familial adenomatous polyposis coli. Two common European MUTYH mutations account for 90% of MUTYH-associated polyposis (MAP). We aimed to examine the incidence of MAP in Ireland. A retrospective cohort study was undertaken. Patients undergoing MUTYH testing from 2003-2016 were identified by searching electronic databases using terms "MUTYH" and "MYH"...
December 12, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28644588/clinical-consensus-guidelines-on-the-application-of-cerebrospinal-fluid-biomarkers-for-alzheimer-s-disease-diagnosis-recommendations-of-the-irish-network-for-biomarkers-in-neurodegeneration
#4
A M Miller, E Begley, R Coen, M Doyle, J Dunne, S Hutchinson, S P Kennelly, R A Kenny, R P Killeen, A Lynch, S O'Dwyer, C O'Neill, S S O'Sullvan, M J Rowan, N Sheehy, C McGuigan, B A Lawlor
It is accepted that a lumbar puncture (LP) and cerebrospinal fluid (CSF) biomarker analysis support the routine diagnostic work-up for the differential diagnosis of dementia due to Alzheimer's disease (AD) within certain patient cohorts1. These tests, which measure CSF protein concentrations of amyloid-β42 (Aβ42), total tau (t-tau) and phospho tau (p-tau), were recently validated, accredited and made available clinically for the first time in Ireland. A working group, comprising Irish clinical and scientific researchers, met to review a) the validation results; b) international consensus opinions, and c) research and clinical evidence as to the clinical utility of CSF biomarker analysis for AD dementia diagnosis...
December 12, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28644584/autumn-weather-and-winter-increase-in-cerebrovascular-disease-mortality
#5
R McDonagh, J Harbison
Mortality from cerebrovascular disease increases in winter but the cause is unclear. Ireland's oceanic climate means that it infrequently experiences extremes of weather. We examined how weather patterns relate to stroke mortality in Ireland. Seasonal data for Sunshine (% of average), Rainfall (% of average) and Temperature (degrees Celsius above average) were collected for autumn (September-November) and winter (December-February) using official Irish Meteorological Office data. National cerebrovascular mortality data was obtained from Quarterly Vital Statistics...
December 12, 2016: Irish Medical Journal
https://www.readbyqxmd.com/read/28644156/clinical-case-of-the-month-a-57-year-old-man-with-an-axillary-mass
#6
Palak Desai, Andrew Myers, Brian Boulmay, Fred A Lopez
A 57-year-old man presented to the surgical oncology clinic with a mildly tender mass under his right arm. Four years prior, the patient had a melanoma removed from his right shoulder along with an ipsilateral right axillary sentinel lymph sampling. Computed tomography (CT) scan was negative for metastatic disease at that time. The patient did not undergo completion axillary node dissection and was lost to follow-up. The patient was originally from Australia, did not tan but reported multiple sunburns before age 18...
May 2017: Journal of the Louisiana State Medical Society: Official Organ of the Louisiana State Medical Society
https://www.readbyqxmd.com/read/28639298/prevalence-patterns-and-factors-associated-with-psychotropic-use-in-older-adults-with-intellectual-disabilities-in-ireland
#7
M O'Dwyer, J Peklar, N Mulryan, P McCallion, M McCarron, M C Henman
BACKGROUND: People with intellectual disability (ID) are at increased risk of exposure to psychotropic drugs and psychotropic polypharmacy because of the higher prevalence of mental health conditions present and more controversially, the use of these agents to treat challenging behaviours. Despite the fact that many adults with ID are exposed to psychotropic polypharmacy, few studies to date have focused on the patterns of use of multiple psychotropics, or factors associated with psychotropic polypharmacy, particularly in the older population...
June 21, 2017: Journal of Intellectual Disability Research: JIDR
https://www.readbyqxmd.com/read/28639034/ageing-health-status-and-coverage-rate-effects-on-community-prescription-costs-in-ireland
#8
Martin Kenneally, Brenda Lynch
AIMS AND OBJECTIVES: This paper aims to explore how GMS drug costs depend on age, gender, income, health status, community drug scheme coverage rates and whether they display significant differences across regions of Ireland. We also aim to find out whether the GMS drug costs of high and low income cohorts respond similarly to changes in their health status. The paper projects GMS drug costs in 2026 and examines the separate cost of population ageing and population growth over the period...
June 21, 2017: European Journal of Health Economics: HEPAC: Health Economics in Prevention and Care
https://www.readbyqxmd.com/read/28632065/muscle-activation-sequencing-of-leg-muscles-during-linear-glide-shot-putting
#9
Róisín M Howard, Richard Conway, Andrew J Harrison
In the shot put, the athlete's muscles are responsible for generating the impulses to move the athlete and project the shot into the air. Information on phasic muscle activity is lacking for the glide shot put event and therefore important technical information for coaches is not currently available. This study provides an electromyography (EMG) analysis of the muscle activity of the legs during shot put. Fifteen right-handed Irish national level shot putters performed six maximum effort throws using the glide shot put technique...
March 1, 2017: Sports Biomechanics
https://www.readbyqxmd.com/read/28631815/expansion-of-sesquiterpene-biosynthetic-gene-clusters-in-pepper-confers-nonhost-resistance-to-the-irish-potato-famine-pathogen
#10
Hyun-Ah Lee, Sejun Kim, Seungill Kim, Doil Choi
Chemical barriers contribute to nonhost resistance, which is defined as the resistance of an entire plant species to nonadapted pathogen species. However, the molecular basis of metabolic defense in nonhost resistance remains elusive. Here, we report genetic evidence for the essential role of phytoalexin capsidiol in nonhost resistance of pepper (Capsicum spp.) to potato late blight Phytophthora infestans using transcriptome and genome analyses. Two different genes for capsidiol biosynthesis, 5-epi-aristolochene synthase (EAS) and 5-epi-aristolochene-1,3-dihydroxylase (EAH), belong to multigene families...
June 20, 2017: New Phytologist
https://www.readbyqxmd.com/read/28630683/erratum-to-the-prevalence-temporal-and-spatial-trends-in-bulk-tank-equivalent-milk-fat-depression-in-irish-milk-recorded-herds
#11
Catherine I Carty, Alan G Fahey, Morgan R Sheehy, Steve Taylor, Ian J Lean, Conor G McAloon, Luke O'Grady, Finbar J Mulligan
[This corrects the article DOI: 10.1186/s13620-017-0092-y.].
2017: Irish Veterinary Journal
https://www.readbyqxmd.com/read/28629585/sensory-capability-of-young-middle-aged-and-elderly-irish-assessors-to-identify-beef-steaks-of-varying-texture
#12
Paula M Conroy, Maurice G O' Sullivan, Ruth M Hamill, Joseph P Kerry
This study assessed the capability of various Irish assessor age cohorts to identify beef steaks of varying texture. Varying steak textures Moderately Tough (MTH), Moderately Tender (MTR) and Tender (TR) were achieved by aging beef longissimus thoracis et lumborum (LTL) muscle for 2, 7 and 21days respectively. Warner Bratzler Shear Force (WBSF) was measured to standardise the samples. Sensory evaluation was carried using 428 participants; 18-30yrs (years) (n=143), 31-60yrs (n=80), 61-75yrs (n=99) and 76-85yrs old (n=106)...
May 28, 2017: Meat Science
https://www.readbyqxmd.com/read/28624279/the-use-of-national-level-data-to-describe-trends-in-intramammary-antimicrobial-usage-on-irish-dairy-farms-from-2003-to-2015
#13
Simon J More, Tracy A Clegg, Finola McCoy
In this study, we used national-level data to describe trends in on-farm intramammary antimicrobial usage in Ireland from 2003 to 2015. We calculated actual sales of intramammary tubes and the quantity of active substance sold, by year, product type [lactation or dry cow therapy (DCT)], antimicrobial group, World Health Organization antimicrobial classification, and from 2009 to 2015, prescribing route. We also estimated on-farm usage of lactation and dry cow intramammary antimicrobials using defined daily dose (DDDvet) and defined course dose (DCDvet) calculations, and dry cow coverage...
June 14, 2017: Journal of Dairy Science
https://www.readbyqxmd.com/read/28623184/scaling-up-psychological-treatments-a-countrywide-test-of-the-online-training-of-therapists
#14
Christopher G Fairburn, Elizabeth Allen, Suzanne Bailey-Straebler, Marianne E O'Connor, Zafra Cooper
BACKGROUND: A major barrier to the widespread dissemination of psychological treatments is the way that therapists are trained. The current method is not scalable. OBJECTIVE: Our objective was to conduct a proof-of-concept study of Web-centered training, a scalable online method for training therapists. METHODS: The Irish Health Service Executive identified mental health professionals across the country whom it wanted to be trained in a specific psychological treatment for eating disorders...
June 16, 2017: Journal of Medical Internet Research
https://www.readbyqxmd.com/read/28622794/schmallenberg-virus-predicting-within-herd-seroprevalence-using-bulk-tank-milk-antibody-titres-and-exploring-individual-animal-antibody-titres-using-empirical-distribution-functions-edf
#15
Á B Collins, J Grant, D Barrett, M L Doherty, A Hallinan, J F Mee
Schmallenberg virus (SBV) is transmitted by Culicoides spp. biting midges and can cause abortions and congenital malformations in ruminants and milk drop in dairy cattle. Estimating true within-herd seroprevalence is an essential component of efficient and cost-effective SBV surveillance programs. The objectives of this study were: (1) determine the correlation between bulk-tank milk (BTM)-ELISA results and within-herd seroprevalence, (2) evaluate the ability of BTM-ELISA results to predict within-herd seroprevalence and (3) explore the distributions of individual animal serology results using novel statistical methodology...
August 1, 2017: Preventive Veterinary Medicine
https://www.readbyqxmd.com/read/28621753/media-coverage-of-alcohol-issues-a-critical-political-economy-framework-a-case-study-from-ireland
#16
Julien Mercille
There is a growing literature on news media representations of alcohol-related issues. However, current scholarship has neglected critical political economic frameworks to interpret media coverage of alcohol. This paper presents such a framework that conceives of news organisations as corporations that share the values and interests of political and economic elites. The media are thus expected to present viewpoints that are more aligned with the alcohol industry than the scientific consensus on public health policy would warrant...
June 16, 2017: International Journal of Environmental Research and Public Health
https://www.readbyqxmd.com/read/28620721/a-novel-gain-of-function-mutation-in-the-itpr1-suppressor-domain-causes-spinocerebellar-ataxia-with-altered-ca-2-signal-patterns
#17
Jillian P Casey, Taisei Hirouchi, Chihiro Hisatsune, Bryan Lynch, Raymond Murphy, Aimee M Dunne, Akitoshi Miyamoto, Sean Ennis, Nick van der Spek, Bronagh O'Hici, Katsuhiko Mikoshiba, Sally Ann Lynch
We report three affected members, a mother and her two children, of a non-consanguineous Irish family who presented with a suspected autosomal dominant spinocerebellar ataxia characterized by early motor delay, poor coordination, gait ataxia, and dysarthria. Whole exome sequencing identified a novel missense variant (c.106C>T; p.[Arg36Cys]) in the suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor gene (ITPR1) as the cause of the disorder, resulting in a molecular diagnosis of spinocerebellar ataxia type 29...
June 15, 2017: Journal of Neurology
https://www.readbyqxmd.com/read/28620485/variation-in-activity-levels-amongst-dogs-of-different-breeds-results-of-a-large-online-survey-of-dog-owners-from-the-uk
#18
Emily Pickup, Alexander J German, Emily Blackwell, Mark Evans, Carri Westgarth
Regular physical activity is an important means of promoting health, both in people and their pets. Walking is the most common method used for dogs, but there is a lack of clarity on how much daily activity different breeds of dog require. Data from an online survey of UK dog owners were collected between June and August in 2014. The University of Liverpool Ethics Committee approved the project, and owners consented to data use. The initial dataset (17 028 dogs) was first cleaned to remove erroneous data, and then edited to remove mixed breed dogs, leaving a total of 12 314 dogs from known pedigree breeds...
2017: Journal of Nutritional Science
https://www.readbyqxmd.com/read/28615174/supreme-court-rejects-northern-irish-woman-s-appeal-for-nhs-abortion-in-england
#19
Clare Dyer
No abstract text is available yet for this article.
June 14, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28614802/mitochondrial-dysregulation-and-glycolytic-insufficiency-functionally-impair-cd8-t-cells-infiltrating-human-renal-cell-carcinoma
#20
Peter J Siska, Kathryn E Beckermann, Frank M Mason, Gabriela Andrejeva, Allison R Greenplate, Adam B Sendor, Yun-Chen J Chiang, Armando L Corona, Lelisa F Gemta, Benjamin G Vincent, Richard C Wang, Bumki Kim, Jiyong Hong, Chiu-Lan Chen, Timothy N Bullock, Jonathan M Irish, W Kimryn Rathmell, Jeffrey C Rathmell
Cancer cells can inhibit effector T cells (Teff) through both immunomodulatory receptors and the impact of cancer metabolism on the tumor microenvironment. Indeed, Teff require high rates of glucose metabolism, and consumption of essential nutrients or generation of waste products by tumor cells may impede essential T cell metabolic pathways. Clear cell renal cell carcinoma (ccRCC) is characterized by loss of the tumor suppressor von Hippel-Lindau (VHL) and altered cancer cell metabolism. Here, we assessed how ccRCC influences the metabolism and activation of primary patient ccRCC tumor infiltrating lymphocytes (TIL)...
June 15, 2017: JCI Insight
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