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https://www.readbyqxmd.com/read/28449214/a-rising-incidence-and-poorer-male-outcomes-characterise-early-onset-paediatric-inflammatory-bowel-disease
#1
A Coughlan, R Wylde, L Lafferty, S Quinn, A Broderick, B Bourke, S Hussey
BACKGROUND: The incidence of paediatric inflammatory bowel disease diagnosed before age 10 years is reportedly increasing, but national data are limited. AIM: To characterise the epidemiology, phenotype and clinical outcomes of children diagnosed with inflammatory bowel disease before age 10 years, and compare with data from children diagnosed aged 10-16 years. METHODS: A review of all Irish cases of early onset inflammatory bowel disease (diagnosis <10 years, EO-IBD) presenting between January 2000 and December 2014 was undertaken and compared to a cohort of later onset paediatric inflammatory bowel disease patients (diagnosis between 10 and 16 years, LO-IBD)...
April 27, 2017: Alimentary Pharmacology & Therapeutics
https://www.readbyqxmd.com/read/28444243/sexual-activity-and-relationship-quality-in-middle-and-older-age-findings-from-the-irish-longitudinal-study-on-ageing-tilda
#2
Joanna Orr, Richard Layte, Neil O'Leary
Objectives: This study assessed the association between sexual activity, mismatches in the importance attributed to sex within couples, and relationship quality in older Irish adults. Method: We used data from the Irish Longitudinal Study on Ageing (TILDA) to derive a scale of subjective relationship strain in married or cohabiting individuals. Negative binomial regression was used to assess the association between relationship strain and sexual activity. Separate models assessed the associations with importance of sex and within-couple mismatch in the importance attributed to sex and whether these associations were independent from sexual activity...
April 21, 2017: Journals of Gerontology. Series B, Psychological Sciences and Social Sciences
https://www.readbyqxmd.com/read/28440966/lead-levels-in-vegetables-from-artisanal-mining-sites-of-dilimi-river-bukuru-and-barkin-ladi-north-central-nigeria-cancer-and-non-cancer-risk-assessment
#3
Orish Ebere Orisakwe, Emmanuel Ayuba Dagur, Herbert Orji Chidi Mbagwu, Nnaemeka Arinze Udowelle
Lead (Pb) contamination of foods and especially of frequently consumed vegetables is a growing public health concern worldwide. Although levels of exposure in developed countries have declined over the past decades, the same cannot be said of developing countries. Health risk assessment has increasingly been employed to determine the potential hazard of heavy metal exposure to humans. In this study vegetable samples (tomatoes, red pepper, brown beans, lettuce, cabbage, Irish potatoes, onions, green beans and carrot), soil samples, irrigation water and sediment samples were collected from the Dilimi River, Bukuru and Barkin Ladi communities in north central Nigeria and analyzed for Pb content using atomic absorption spectroscopy...
March 1, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28437130/lower-limb-and-trunk-biomechanics-after-fatigue-in-competitive-female-irish-dancers
#4
Catherine Y Wild, Avril Grealish, Diana Hopper
CONTEXT:   Because of the increasing popularity of participation in Irish dance, the incidence of lower limb injuries is high among this competitive population. OBJECTIVE:   To investigate the effects of fatigue on the peak lower limb and trunk angles as well as the peak lower limb joint forces and moments of competitive female Irish dancers during the performance of a dance-specific single-limb landing. DESIGN:   Cross-sectional study...
April 24, 2017: Journal of Athletic Training
https://www.readbyqxmd.com/read/28431569/co-colonisation-with-aspergillus-fumigatus-and-pseudomonas-aeruginosa-is-associated-with-poorer-health-in-cystic-fibrosis-patients-an-irish-registry-analysis
#5
Emma Reece, Ricardo Segurado, Abaigeal Jackson, Siobhán McClean, Julie Renwick, Peter Greally
BACKGROUND: Pulmonary infection is the main cause of death in cystic fibrosis (CF). Aspergillus fumigatus (AF) and Pseudomonas aeruginosa (PA) are the most prevalent fungal and bacterial pathogens isolated from the CF airway, respectively. Our aim was to determine the effect of different colonisation profiles of AF and PA on the clinical status of patients with CF. METHODS: A retrospective analysis of data from the Cystic Fibrosis Registry of Ireland from 2013 was performed to determine the effect of intermittent and persistent colonisation with AF or PA or co-colonisation with both microorganisms on clinical outcome measures in patients with CF...
April 21, 2017: BMC Pulmonary Medicine
https://www.readbyqxmd.com/read/28428669/risk-factors-for-osteoporosis-in-postmenopausal-women
#6
Radojka Bijelic, Snjezana Milicevic, Jagoda Balaban
INTRODUCTION: Scientific studies show that many factors related to lifestyles affect the reduction of bone mineral density and osteoporosis in postmenopausal women. GOAL: The goal of this study was to determine whether smoking, drinking coffee and alcohol in menopausal women contribute to the reduction of bone mass and osteoporosis, as well as the impact of physical activity on bone mass. MATERIAL AND METHODS: The study was carried out as case study and matched controls...
February 2017: Medical Archives
https://www.readbyqxmd.com/read/28428181/irish-mp-calls-for-key-documents-on-pandemrix-to-be-handed-to-lawyers-representing-children-with-narcolepsy
#7
Clare Dyer
No abstract text is available yet for this article.
April 20, 2017: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/28427707/incidence-of-multiple-sclerosis-in-the-republic-of-ireland-a-prospective-population-based-study
#8
K O'Connell, N Tubridy, M Hutchinson, C McGuigan
BACKGROUND: Multiple sclerosis (MS) incidence and prevalence is increasing worldwide, with a disproportionally higher rate in women. Recent studies have questioned the presence of a latitudinal gradient in Europe. Ireland is a high prevalence country for MS with a previously reported North-South gradient making it ideal to further explore this concept. OBJECTIVES: In this study we prospectively determined the incidence rate of newly diagnosed MS in Ireland over a 12-month period and demonstrated the presence of a North-South gradient...
April 2017: Multiple Sclerosis and related Disorders
https://www.readbyqxmd.com/read/28424064/effectiveness-of-triple-therapy-with-direct-acting-antivirals-for-hepatitis-c-genotype-1-infection-application-of-propensity-score-matching-in-a-national-hcv-treatment-registry
#9
Emma Gray, David J Pasta, Suzanne Norris, Aisling O'Leary
BACKGROUND: Observational studies are used to measure the effectiveness of an intervention in non-experimental, real world scenarios at the population level and are recognised as an important component of the evidence pyramid. Such data can be accrued through prospective cohort studies and a patient registry is a proven method for this type of study. The national hepatitis C (HCV) registry was established in Ireland in 2012 with the aim of monitoring the clinical and economic outcomes from new, high cost regimens for the treatment of HCV infection...
April 19, 2017: BMC Health Services Research
https://www.readbyqxmd.com/read/28423857/the-association-between-the-stopp-start-criteria-and-gastro-intestinal-track-bleedings-in-elderly-patients
#10
Anouk Veldhuis, Danielle Sent, Linette Bruin-Huisman, Erna Beers, Ameen Abu-Hanna
Potentially inappropriate prescribing is a common problem, especially in elderly care. To tackle this problem, Irish medical experts have developed a list of criteria when medication should be added or omitted based upon the patient's physical condition and medication use, known as the STOPP and START criteria. The STOPP and START criteria have been formulated to identify the prescribing of potentially inappropriate medicines (PIMs) and potential prescribing omissions (PPOs). One of the most common problems of inappropriate prescribing is gastro-intestinal track bleedings...
2017: Studies in Health Technology and Informatics
https://www.readbyqxmd.com/read/28421870/collaborative-study-on-the-effect-of-grinding-on-the-detection-of-bones-from-processed-animal-proteins-in-feed-by-light-microscopy
#11
Pascal Veys, Viviane Planchon, Ruairi Colbert, Clara Cruz, Geneviève Frick, Ioannis Ioannou, Daniela Marchis, Erik Nordkvist, Inge Paradies-Severin, Arja Pohto, Roland Weiss, Vincent Baeten, Gilbert Berben
Bone fragments are essential structures for the detection of processed animal proteins (PAPs) in feed by light microscopy for official controls according to Annex VI of European Union Regulation EC/152/2009. The preparation of samples submitted for analysis requires a grinding step to make them suitable for microscopic slide preparation and observation. However, there are no technical guidelines set down for this step despite the fact that it can lead to an increase in bone numbers due to fragmentation. This was demonstrated by an in-house study carried out by the Irish National Reference Laboratory (NRL) for animal protein detection...
April 19, 2017: Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
https://www.readbyqxmd.com/read/28419577/decline-in-new-psychoactive-substance-use-disorders-following-legislation-targeting-headshops-evidence-from-national-addiction-treatment-data
#12
Bobby P Smyth, Suzi Lyons, Walter Cullen
INTRODUCTION AND AIMS: New psychoactive substances (NPS) have hedonic effects that may lead to dependence. Headshops selling NPS increased in number in Ireland from late 2009. Legislation was enacted in May and August of 2010 that caused their closure. It is unknown whether such events impact the rate of NPS use disorders. DESIGNS AND METHODS: We conducted a population-based study using the Irish national database of episodes of addiction treatment between 2009 and 2012...
April 16, 2017: Drug and Alcohol Review
https://www.readbyqxmd.com/read/28407037/what-explains-socioeconomic-differences-in-the-speed-of-heart-rate-recovery-to-postural-challenge
#13
Cathal McCrory, Lisa F Berkman, Patrick V Moore, Rose Anne Kenny
Background: Much recent work has focused on the value of heart rate recovery (HRR) as a marker of cardiovascular health and a predictor of mortality. This article explores socioeconomic variation in HRR following exposure to a potent physiological stressor. Methods: The sample involved a nationally representative cohort of 4,475 community-dwelling older persons aged 50 years and older participating in the Irish Longitudinal Study on Ageing (TILDA). Participants completed an active stand (ie, vertical stand from a supine position) as part of a detailed clinic-based cardiovascular health assessment...
April 12, 2017: Journals of Gerontology. Series A, Biological Sciences and Medical Sciences
https://www.readbyqxmd.com/read/28406370/farmers-have-hearts-the-prevalence-of-risk-factors-for-cardiovascular-disease-among-a-sub-group-of-irish-livestock-farmers
#14
Diana van Doorn, Noel Richardson, Aoife Osborne
OBJECTIVES: Despite international findings that farmers have better health outcomes than other occupation groups, Irish farmers are found to be a high risk group for cardiovascular disease (CVD). Early detection of CVD through preventive health measurements, such as screening of high risk groups, can contribute to a reduction of CVD cases. Farmers, however, represent a 'challenging' group in terms of engaging in preventive health behaviors. This study examined the prevalence of cardiovascular risk factors among male Irish livestock farmers who participated in heart screening as part of a workplace health intervention...
April 13, 2017: Journal of Agromedicine
https://www.readbyqxmd.com/read/28400539/mass-cytometry-deep-phenotyping-of-human-mononuclear-phagocytes-and-myeloid-derived-suppressor-cells-from-human-blood-and-bone-marrow
#15
Mikael Roussel, P Brent Ferrell, Allison R Greenplate, Faustine Lhomme, Simon Le Gallou, Kirsten E Diggins, Douglas B Johnson, Jonathan M Irish
The monocyte phagocyte system (MPS) includes numerous monocyte, macrophage, and dendritic cell (DC) populations that are heterogeneous, both phenotypically and functionally. In this study, we sought to characterize those diverse MPS phenotypes with mass cytometry (CyTOF). To identify a deep phenotype of monocytes, macrophages, and DCs, a panel was designed to measure 38 identity, activation, and polarization markers, including CD14, CD16, HLA-DR, CD163, CD206, CD33, CD36, CD32, CD64, CD13, CD11b, CD11c, CD86, and CD274...
April 11, 2017: Journal of Leukocyte Biology
https://www.readbyqxmd.com/read/28399224/species-identification-and-resistance-status-of-anopheles-gambiae-s-l-diptera-culicidae-mosquitoes-in-guinea
#16
K Keita, D Camara, Y Barry, R Ossè, L Wang, M Sylla, D Miller, L Leite, P Schopp, G G Lawrence, M Akogbéto, E M Dotson, T Guilavogui, M Keita, S R Irish
Insecticide resistance is one of the primary threats to the recent gains in malaria control. This is especially true in Guinea, where long-lasting insecticidal nets are currently the primary vector control intervention. To better inform the national malaria control program on the current status of insecticide resistance in Guinea, resistance bioassays were conducted, using Anopheles gambiae s.l. Giles, in three sites. Molecular analyses were also done on An. gambiae s.l. to determine the species and find whether the target-site mutations kdr and Ace1R were present...
March 2, 2017: Journal of Medical Entomology
https://www.readbyqxmd.com/read/28398688/survival-outcomes-for-cutaneous-angiosarcoma-of-the-scalp-versus-face
#17
Jonathan M Bernstein, Jonathan C Irish, Dale H Brown, David Goldstein, Peter Chung, Albiruni R Abdul Razak, Charles Catton, Ralph W Gilbert, Patrick J Gullane, Brian O'Sullivan
BACKGROUND: The primary purpose of this study was to examine whether angiosarcoma outcomes differ for the scalp and face. METHODS: We conducted a retrospective outcomes analysis of 50 patients with cutaneous angiosarcoma treated by curative intent identified from the Princess Margaret Cancer Centre Registry (from 1958 to 2014). RESULTS: Median survival was 26 months (95% confidence interval [CI], 17.6-34.6) and median follow-up 29 months. For the scalp and face, respectively, the 5-year locoregional control rate was 9% and 53% (p = ...
April 11, 2017: Head & Neck
https://www.readbyqxmd.com/read/28393455/hlamatchmaker-is-effective-for-selecting-appropriate-platelet-units-for-alloimmunised-thrombocytopaenic-patients-who-are-refractory-to-random-donor-platelets
#18
C O'Rafferty, G Rooney, R Hagan, M Woolfson, D O'Donghaile, J Fitzgerald
BACKGROUND: HLAMatchmaker has been used in the Irish Blood Transfusion Service (IBTS) to select platelets for HLA-alloimmunised, platelet refractory thrombocytopaenic patients since 2006. Although available since 2002, only three studies have been published supporting the programme's effectiveness for this indication. OBJECTIVES: We sought to examine increments to HLA-matched platelets (HMPs) at various matchmaker scores and to examine the impact of transfusing older platelets and ABO-mismatched platelets to this patient group...
April 10, 2017: Transfusion Medicine
https://www.readbyqxmd.com/read/28390434/surgical-site-infections-following-oral-cavity-cancer-resection-and-reconstruction-is-a-risk-factor-for-plate-exposure
#19
Christopher M Yao, Hedyeh Ziai, Gordon Tsang, Andrea Copeland, Dale Brown, Jonathan C Irish, Ralph W Gilbert, David P Goldstein, Patrick J Gullane, John R de Almeida
BACKGROUND: Plate-related complications following head and neck cancer ablation and reconstruction remains a challenging problem often requiring further management and reconstructive surgeries. We aim to identify an association between surgical site infections (SSI) and plate exposure. METHODS: A retrospective study between 1997 and 2014 was performed to study the association between postoperative SSI and plate exposures. Eligible patients included those with a history of oral squamous cell carcinoma who underwent surgical resection, neck dissection, and free tissue reconstruction...
April 8, 2017: Journal of Otolaryngology—Head & Neck Surgery
https://www.readbyqxmd.com/read/28389702/cooperative-robot-assistant-for-vitreoretinal-microsurgery-development-of-the-rvrms-and-feasibility-studies-in-an-animal-model
#20
Yi-Qi Chen, Ji-Wei Tao, Ling-Ya Su, Liang Li, Shi-Xin Zhao, Yang Yang, Li-Jun Shen
PURPOSE: The purpose of the study was to describe the development of a robotic aided surgical system named RVRMS (robotic vitreous retinal microsurgery system) and to evaluate the capability for using it to perform vitreoretinal surgery. METHODS: The RVRMS was designed and built to include the key components of two independent arms. End-effectors of each arm fix various surgical instruments and perform intraocular manipulation. To evaluate properly the RVRMS, robot-assisted 23-gauge surgical tasks including endolaser for retinal photocoagulation, pars plana vitrectomy (PPV), retinal foreign body removal and retinal vascular cannulation were performed in two different sizes of an animal model...
April 8, 2017: Graefe's Archive for Clinical and Experimental Ophthalmology
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