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https://www.readbyqxmd.com/read/27470079/genetic-risk-of-extranodal-natural-killer-t-cell-lymphoma-a-genome-wide-association-study
#1
Zheng Li, Yi Xia, Li-Na Feng, Jie-Rong Chen, Hong-Min Li, Jing Cui, Qing-Qing Cai, Kar Seng Sim, Maarja-Liisa Nairismägi, Yurike Laurensia, Wee Yang Meah, Wen-Sheng Liu, Yun-Miao Guo, Li-Zhen Chen, Qi-Sheng Feng, Chi Pui Pang, Li Jia Chen, Soo Hong Chew, Richard P Ebstein, Jia Nee Foo, Jianjun Liu, Jeslin Ha, Lay Poh Khoo, Suk Teng Chin, Yi-Xin Zeng, Tin Aung, Balram Chowbay, Colin Phipps Diong, Fen Zhang, Yan-Hui Liu, Tiffany Tang, Miriam Tao, Richard Quek, Farid Mohamad, Soo Yong Tan, Bin Tean Teh, Siok Bian Ng, Wee Joo Chng, Choon Kiat Ong, Yukinori Okada, Soumya Raychaudhuri, Soon Thye Lim, Wen Tan, Rou-Jun Peng, Chiea Chuen Khor, Jin-Xin Bei
BACKGROUND: Extranodal natural killer T-cell lymphoma (NKTCL), nasal type, is a rare and aggressive malignancy that occurs predominantly in Asian and Latin American populations. Although Epstein-Barr virus infection is a known risk factor, other risk factors and the pathogenesis of NKTCL are not well understood. We aimed to identify common genetic variants affecting individual risk of NKTCL. METHODS: We did a genome-wide association study of 189 patients with extranodal NKTCL, nasal type (WHO classification criteria; cases) and 957 controls from Guangdong province, southern China...
September 2016: Lancet Oncology
https://www.readbyqxmd.com/read/27411422/systemic-onset-juvenile-idiopathic-arthritis-with-macrophage-activation-syndrome-and-coronary-artery-dilatation-misdiagnosed-as-kawasaki-disease
#2
Gonca Keskindemirci, Nuray Aktay Ayaz, Neslihan Melikoğlu, Helen Bornaun, Çiğdem Aydoğmuş, Esin Aldemir, Gönül Aydoğan
Systemic onset juvenile idiopathic arthritis (SoJIA) is characterized by arthritis, fever and visceral organ involvement including hepatosplenomegaly, lympadenopathy and serositis. This is a case of SoJIA misdiagnosed as Kawasaki disease (KD) and developed machrophage activation syndrome (MAS) secondary to Ebstein-Barr virus (EBV) infection. It is presented to point out the conditions that may come along. First of all, SoJIA should be kept in mind while making the differential diagnosis of coronary arterial ectasias and dilatations usually seen in vasculitic diseases like KD...
September 2015: Turkish Journal of Pediatrics
https://www.readbyqxmd.com/read/27339563/a-retrospective-evaluation-of-lymphadenopathy-in-children-in-a-single-center-s-experience
#3
Sevgi Buyukbese Sarsu, Kamil Sahin
OBJECTIVE: To determine the causes of lymphadenopathies in children living in our region, and detect the frequency of malignant disease. METHODS: Our study evaluated demographic characteristics, lymph node involvement sites, tests, and viral serologiesperformed to search for the presence of infection, and ultrasonographic, and histologic findings of 1700 children who were referred to the outpatient clinics of the Paediatric Diseases and Paediatric Surgery between January 2012, and January 2015...
June 2016: JPMA. the Journal of the Pakistan Medical Association
https://www.readbyqxmd.com/read/26832181/natural-killer-like-t-cell-lymphoma-localized-to-the-terminal-ileum-case-report
#4
Ümit Bayol, Süheyla Cumurcu, Kerem Karaman, Cem Tuğmen, Çağlar Akdeniz, Özlem Akman, Saime Ünlüoğlu
Intestinal intraepithelial lymphocytes are non-organized lymphoid populations that are composed of heterogeneous subsets with diverse ontogeny and phenotypes, and the differential diagnosis is crucial. A 43-year-old male patient underwent an emergency laparotomy due to a perforated mass of the terminal ileum. A right hemicolectomy plus small bowel resection was performed. Histopathological examination showed medium to large cells with vesicular nuclei, including marked nucleoli with large, colorless cytoplasm...
2016: Türk Patoloji Dergisi
https://www.readbyqxmd.com/read/26709095/expression-of-serum-sialic-acid-early-antigen-iga-and-viral-capsid-antigen-iga-in-nasopharynx-cancer-patients-the-diagnostic-implication-of-combined-assays
#5
Yuning Sun, Caibo Sun, Endong Zhang
BACKGROUND Ebstein-Barr virus (EBV) plays a critical role in nasopharynx cancer, which can be effectively monitored by serum levels of early antigen antibody (EA-IgA) and viral capsid antigen antibody (VCA-IgA). This study explored the diagnostic value of combined assays of sialic acid (SA), EA-IgA, and VCA-IgA via the expressional assay. MATERIAL AND METHODS A total of 42 nasopharynx cancer patients and 42 benign rhinitis and healthy controls were recruited in this study. Serum EA-IgA and VCA-IgA were tested by enzyme-linked immunosorbent assay (ELISA) and enzymatic assay of serum SA...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26191775/correlation-analysis-of-nasopharyngeal-carcinoma-tnm-staging-with-serum-ea-iga-and-vca-iga-in-ebv-and-vegf-c-and-d
#6
Ruimei Sun, Xiaoli Wang, Xiaojiang Li
BACKGROUND: Nasopharyngeal carcinoma often occurs in humans in the nasopharyngeal epithelium area. Ebstein-Barr (EB) virus plays a key role in the process of nasopharyngeal carcinoma lesions. Early antigen antibody (EA-IgA) and viral capsid antigen IgA (VCA-IgA) of EB virus detection in serum can effectively monitor the process of nasopharyngeal carcinoma lesions. Serum vascular endothelial growth factor (VEGF) -C and VEGF-D expression detection can reflect the distant metastases ability of human tumor cells...
2015: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://www.readbyqxmd.com/read/26148222/cytomegalovirus-and-other-common-enteric-viruses-are-not-commonly-associated-with-nec
#7
Thomas Skeath, Christopher Stewart, Sheila Waugh, Nicholas Embleton, Stephen Cummings, Janet Berrington
AIM: Changes in gut microbiota may contribute to NEC, but most studies focus on bacteria. Case reports suggest a link between cytomegalovirus (CMV) or other enteric viruses and NEC, but there are few case series systematically looking at common potential viral causes. We aimed to assess the presence of candidate viruses in blood or stool of a case series of infants with NEC managed in one surgical centre. METHODS: We identified 22 infants diagnosed with NEC (from November 2011 to March 2014): 17 had suitable blood stored, of whom 14 also had suitable stool samples stored...
January 2016: Acta Paediatrica
https://www.readbyqxmd.com/read/25811010/vitamin-b12-and-vitamin-d-deficiencies-an-unusual-cause-of-fever-severe-hemolytic-anemia-and-thrombocytopenia
#8
Vikas A Mishra, Rishit Harbada, Akhilesh Sharma
The array of diagnostic workup for pyrexia of unknown origin (PUO) generally revolves in searching for infections, inflammatory/autoimmune, and endocrine etiologies. A differential diagnosis of fever, hemolytic anemia, and thrombocytopenia can have etiologies varying from infections like malaria, dengue, cytomegalovirus, Ebstein barr virus, Parvovirus, infective endocarditis, to autoimmune disorder (systemic lupus erythromatosis), vasculitis, hemolytic uremic syndrome, thrombotic thrombocytopenic purpura (TTP), autoimmune hemolytic anemia/Evan's syndrome, paroxysmal nocturnal hemoglobinuri (PNH), or drugs...
January 2015: Journal of Family Medicine and Primary Care
https://www.readbyqxmd.com/read/25624957/central-nervous-system-lymphoma-in-a-3-year-old-male-suffering-from-a-severe-juvenile-xanthogranuloma-the-usefulness-of-perfusion-weighted-imaging-and-diffusion-weighted-imaging-in-the-diagnostics-of-pediatric-brain-tumors
#9
Małgorzata Neska-Matuszewska, Anna Zimny, Krzysztof Kałwak, Marek J Sąsiadek
BACKGROUND: Primary Central Nervous System Lymphomas (PCNSLs) are rare, malignant brain tumors derived from lymphocytes B. Juvenile xanthogranuloma (JXG) is a non-Langerhans histiocytic cell disorder in children which mostly affects the skin. Rare fatalities have been reported in extracutaneous manifestation. Brain magnetic resonance imaging (MRI) is a method of choice in the diagnostics of all neoplastic CNS lesions. Perfusion weighted imaging (PWI) and diffusion weighted imaging (DWI) allow for more detailed analysis of brain tumors including the rate of neoangiogenesis and cellularity...
2015: Polish Journal of Radiology
https://www.readbyqxmd.com/read/25332588/hepatitis-a-virus-infection-associated-hemophagocytic-lymphohistiocytosis-in-two-children
#10
Kirubakaran Navamani, Manivachagan Muthappa Natarajan, Arul Premanand Lionel, Sathish Kumar
Hemophagocytic lymphohistiocytosis (HLH) is a syndrome characterized by high fever, maculopapular rash, neurological symptoms, abnormal liver functions and coagulopathy. Primary HLH is due to an underlying genetic abnormality. Secondary HLH are due to an underlying infection, autoimmune disease or malignancy. Secondary HLH due to viral infections are commonly due to the herpes group commonest of which is the Ebstein Barr virus (EBV). We describe two children with virus associated hemophagocytic lymphohistiocytosis (VAHLH) secondary to hepatitis A infection...
September 2014: Indian Journal of Hematology & Blood Transfusion
https://www.readbyqxmd.com/read/25250166/hepatitis-c-infection-incidence-among-the-non-hodgkin-s-b-cell-lymphoma-patients-in-the-northeast-of-iran
#11
Seyed Amir Aledavood, Mohammad Reza Ghavam-Nasiri, Kamran Ghaffarzadegan, Hamid Reza Raziee, Golnaz Saboori, Kazem Anvari, Samira Mohtashami, Mitra Ahadi, Bahram Memar
BACKGROUND: Various infectious agents like Ebstein Barr Virus (EBV), HTLV-1 and Helicobacter pylori have known as etiologic factors in different sub-types of lymphoma. Although Hepatitis C virus (HCV) has not only been important for its hepatotropism and hepatitis development, but also in recent years its association with some forms of non- Hodgkin's lymphoma (NHL), especially B cell NHL, has reported.In some countries, the rate of B cell NHL development in HCV infected patients was four times more than general population, and then association between HCV infection and B-NHL has proposed in many studies...
2014: Iranian Journal of Cancer Prevention
https://www.readbyqxmd.com/read/25034095/gianotti-crosti-syndrome-associated-with-ebstein-barr-virus-and-parvovirus-b-19-coinfection-in-a-male-adult-case-report-and-review-of-the-literature
#12
Jelena Stojkovic-Filipovic, Dusan Skiljevic, Dimitrije Brasanac, Ljiljana Medenica
Gianotti-Crosti syndrome (GCS) is a self-limiting, mostly childhood-appearing, cutaneous eruption with characteristic symmetric areal distribution. The original cases, described by Gianotti in 1955, were associated with hepatitis B virus infection, but other viral and bacterial infections, as well as immunizations, have been implied in etiology of this condition. Adult cases are rare and have been reported almost exclusively in women. We present the case of a 20-year-old Caucasian man who had typical clinical presentation: monomorphic pale, pink-to-flesh - colored or erythematous papules and papulovesicles localized symmetrically over the extensor surfaces of the extremities, buttocks and the face; some lesions were detected on knees, elbows and palms, as well...
February 2016: Giornale Italiano di Dermatologia e Venereologia: Organo Ufficiale, Società Italiana di Dermatologia e Sifilografia
https://www.readbyqxmd.com/read/24718007/nasal-t-cell-lymphoma-a-rare-entity
#13
Maliha Kazi, Mubasher Ikram, Montasir Junaid
Nasal type of Natural Killer (NK)/T cell lymphoma manifests in the nasal cavity. Approximately 95% of them are associated with EBV(Ebstein Barr Virus) with a strong predilection for the Asian population. It has certain systemic and localized symptoms which aid in diagnosis of the condition. However, the histological criteria is pivotal in confirming the diagnosis as well as aiding in confirming the association of EBV. Nasal type of NK/T cell lymphoma has a guarded prognosis. Treatment plan include radiotherapy with concurrent chemotherapy...
March 2014: Journal of the College of Physicians and Surgeons—Pakistan: JCPSP
https://www.readbyqxmd.com/read/24652042/epigenetics-of-multiple-sclerosis-an-updated-review
#14
REVIEW
Cem İsmail Küçükali, Murat Kürtüncü, Arzu Çoban, Merve Çebi, Erdem Tüzün
Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease characterized with autoimmune response against myelin proteins and progressive axonal loss. The heterogeneity of the clinical course and low concordance rates in monozygotic twins have indicated the involvement of complex heritable and environmental factors in MS pathogenesis. MS is more often transmitted to the next generation by mothers than fathers suggesting an epigenetic influence. One of the possible reasons of this parent-of-origin effect might be the human leukocyte antigen-DRB1*15 allele, which is the major risk factor for MS and regulated by epigenetic mechanisms such as DNA methylation and histone deacetylation...
June 2015: Neuromolecular Medicine
https://www.readbyqxmd.com/read/24596757/nasopharyngeal-mucoepidermoid-carcinoma-a-common-entity-at-an-uncommon-location
#15
A L Hemalatha, Sharath Kumar H K, Geetanjali S, Giripunja M, Shashikumar S D
Mucoepidermoid carcinomas mostly occur in the major salivary glands, the minor salivary glands of oral cavity and in the lacrimal glands. These tumours rarely occur in the sino-nasal tract. When they occur in the sino-nasal tract, the most frequent site is the maxillary antrum, followed by the nasal cavity, the nasopharynx and the ethmoidal sinuses. As per review of literature, nasopharyngeal mucoepidermoid carcinomas account for 0.6% of salivary gland tumours and 4.8% of mucoepidermoid carcinomas. Extensive literature search revealed 21 cases of nasopharyngeal mucoepidermoid carcinomas reported till date...
January 2014: Journal of Clinical and Diagnostic Research: JCDR
https://www.readbyqxmd.com/read/24585919/endobronchial-leiomyoma-in-an-immunocompetent-four-year-old-female-child
#16
Pallav Gupta, Riti Aggarwal, Prashant Rijal, Krishan Chugh
Pulmonary leiomyoma are uncommonly encountered benign mesenchymal neoplasms in children, usually found in immunosuppressed individuals in association with human immunodeficiency virus or Ebstein-Barr virus infection. We describe an interesting case of a 4-year-old immunocompetent girl who presented with pleural effusion and lung collapse secondary to endobronchial leiomyoma. She underwent a left thoracotomy and a left pneumonectomy for excision of the bronchial mass.
March 2014: Asian Cardiovascular & Thoracic Annals
https://www.readbyqxmd.com/read/24374875/malignancy-and-mortality-in-pediatric-patients-with-inflammatory-bowel-disease-a-multinational-study-from-the-porto-pediatric-ibd-group
#17
MULTICENTER STUDY
Lissy de Ridder, Dan Turner, David C Wilson, Sibylle Koletzko, Javier Martin-de-Carpi, Ulrika L Fagerberg, Christine Spray, Malgorzata Sladek, Ron Shaoul, Eleftheria Roma-Giannikou, Jiri Bronsky, Daniela E Serban, Salvatore Cucchiara, Gabor Veres, Frank M Ruemmele, Iva Hojsak, Kaija L Kolho, Ieuan H Davies, Marina Aloi, Paolo Lionetti, Gigi Veereman-Wauters, Christian P Braegger, Eunice Trindade, Anne V Wewer, Almuthe Hauer, Arie Levine
BACKGROUND: The combination of the severity of pediatric-onset inflammatory bowel disease (IBD) phenotypes and the need for intense medical treatment may increase the risk of malignancy and mortality, but evidence regarding the extent of the problem is scarce. Therefore, the Porto Pediatric IBD working group of ESPGHAN conducted a multinational-based survey of cancer and mortality in pediatric IBD. METHODS: A survey among pediatric gastroenterologists of 20 European countries and Israel on cancer and/or mortality in the pediatric patient population with IBD was undertaken...
February 2014: Inflammatory Bowel Diseases
https://www.readbyqxmd.com/read/24283643/neuralgic-amyotrophy-and-infectious-mononucleosis-a-case-report
#18
T Esmonde, W Gamble, V Patterson
A 27 year old man developed neuralgic amyotrophy of the right upper limb 5 weeks after an acute febrile illness which was proven serologically to be caused by Ebstein-Barr virus. The weakness developed in a limb that had been used to perform heavy manual labour. A parallel with a similar phenomenon described in association with paralytic poliomyelitis is noted.-
July 1995: European Journal of Neurology: the Official Journal of the European Federation of Neurological Societies
https://www.readbyqxmd.com/read/24060945/recurrent-ebstein-barr-virus-associated-diffuse-large-b-cell-lymphoma-in-an-ascending-aorta-graft
#19
Crystal R Bonnichsen, Joseph A Dearani, Joseph J Maleszewski, Joseph P Colgan, Eric E Williamson, Naser M Ammash
No abstract text is available yet for this article.
September 24, 2013: Circulation
https://www.readbyqxmd.com/read/23622586/pediatric-renal-transplantation-a-single-center-experience
#20
A Kavaz, Z B Özçakar, B Bulum, A Tüzüner, K Keven, Ş Şengül, M Ekim, F Yalçınkaya
Renal transplantation is the treatment of choice for children with end-stage renal disease. The aim of this study was to evaluate retrospectively of our 37 pediatric renal allograft recipients, including 20 boys and 17 girls from July 2007 to August 2012. The overall mean age at transplantation was 12.16 ± 4.25 years. Three patients (8.1%) were transplanted preemptively; two were ABO-incompatible transplantations. The majority of recipients received living donor grafts (81%). The mean duration of follow-up was 25...
April 2013: Transplantation Proceedings
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