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https://www.readbyqxmd.com/read/28928885/associations-of-epstein-barr-virus-dna-in-pbmcs-and-the-subtypes-with-breast-cancer-risk
#1
Wei Zhang, Min-Yi Wang, Xue-Ling Wei, Ying Lin, Feng-Xi Su, Xiao-Ming Xie, Lu-Ying Tang, Ze-Fang Ren
Objective: Epstein-Barr virus (EBV) has been found to be implicated in the development of breast cancer. The purpose of the present study was to identify the associations of EBV DNA and the subtypes in peripheral blood mononuclear cells (PBMCs) with the risk of breast cancer. Material and Methods: A case-control study with 671 breast cancer cases and 859 age-matched controls was conducted in Guangzhou, China. Face-to-face interviews were performed and blood samples were collected immediately after admission to the hospital for patients or after the interview for controls...
2017: Journal of Cancer
https://www.readbyqxmd.com/read/28926591/no-evidence-for-the-presence-of-epstein-barr-virus-in-squamous-cell-carcinoma-of-the-mobile-tongue
#2
Torben Wilms, Gulfaraz Khan, Philip J Coates, Nicola Sgaramella, Robin Fåhraeus, Asma Hassani, Pretty S Philip, Lena Norberg Spaak, Luigi Califano, Giuseppe Colella, Katarina Olofsson, Christos Loizou, Renato Franco, Karin Nylander
Squamous cell carcinoma of the head and neck (SCCHN) comprises a large group of cancers in the oral cavity and nasopharyngeal area that typically arise in older males in association with alcohol/tobacco usage. Within the oral cavity, the mobile tongue is the most common site for tumour development. The incidence of tongue squamous cell carcinoma (TSCC) is increasing in younger people, which has been suggested to associate with a viral aetiology. Two common human oncogenic viruses, human papilloma virus (HPV) and Epstein-Barr virus (EBV) are known causes of certain types of SCCHN, namely the oropharynx and nasopharynx, respectively...
2017: PloS One
https://www.readbyqxmd.com/read/28910751/chromatin-reorganisation-in-epstein-barr-virus-infected-cells-and-its-role-in-cancer-development
#3
REVIEW
Michelle J West
The oncogenic Epstein-Barr virus (EBV) growth transforms B cells and drives lymphoma and carcinoma development. The virus encodes four key transcription factors (EBNA2, EBNA3A, EBNA3B and EBNA3C) that hijack host cell factors to bind gene control elements and reprogramme infected B cells. These viral factors predominantly target long-range enhancers to alter the expression of host cell genes that control B cell growth and survival and facilitate virus persistence. Enhancer and super-enhancer binding by these EBNAs results in large-scale reorganisation of three-dimensional enhancer-promoter architecture to drive the overexpression of oncogenes, the silencing of tumour suppressors and the modulation of transcription, cell-cycle progression, migration and adhesion...
September 11, 2017: Current Opinion in Virology
https://www.readbyqxmd.com/read/28904201/heterogeneity-of-the-epstein-barr-virus-major-internal-repeat-reveals-evolutionary-mechanisms-of-ebv-and-a-functional-defect-in-the-prototype-ebv-strain-b95-8
#4
Mohammed Ba Abdullah, Richard Palermo, Anne Palser, Nicholas E Grayson, Paul Kellam, Samantha Correia, Agnieszka Szymula, Rob White
Epstein-Barr virus (EBV) is a ubiquitous pathogen of humans that can cause several types of lymphoma and carcinoma. Like other herpesviruses, EBV has diversified both through co-evolution with its host, and genetic exchange between virus strains. Sequence analysis of the EBV genome is unusually challenging, because of the large number and length of repeat regions within the virus. Here we describe the sequence assembly and analysis of the large internal repeat of EBV (IR1 or BamW repeats) from over 70 strains...
September 13, 2017: Journal of Virology
https://www.readbyqxmd.com/read/28870905/transforming-growth-factor-%C3%AE-interleukin-10-and-serological-markers-in-ebv-associated-gastric-carcinoma
#5
Dariusz Pachnia, Bartłomiej Drop, Anna Dworzańska, Ewa Kliszczewska, Małgorzata Polz-Dacewicz
BACKGROUND/AIM: The association between Epstein-Barr virus (EBV) and gastric cancer (GC) has been reported by many researchers. Immunosuppressive cytokines, such as interleukin-10 (IL-10) and transforming growth factor β (TGFβ), play an important role in the tumor process. The aim of the present study was to detect antibodies against EBV and explore the levels of TGFβ and IL-10 in Polish GC patients. PATIENTS AND METHODS: Fifty patients with GC and 50 hospitalized individuals without GC (control group) were enrolled in the study...
September 2017: Anticancer Research
https://www.readbyqxmd.com/read/28855411/epstein-barr-virus-cytomegalovirus-and-multiple-sclerosis-susceptibility-a-multiethnic-study
#6
Annette Langer-Gould, Jun Wu, Robyn Lucas, Jessica Smith, Edlin Gonzales, Lilyana Amezcua, Samantha Haraszti, Lie Hong Chen, Hong Quach, Judith A James, Lisa F Barcellos, Anny H Xiang
OBJECTIVE: To determine whether Epstein-Barr virus (EBV) or cytomegalovirus (CMV) seropositivity is associated with multiple sclerosis (MS) in blacks and Hispanics and to what extent measures of the hygiene hypothesis or breastfeeding could explain these findings. EBV and CMV have been associated with MS risk in whites, and the timing and frequency of both viruses vary by factors implicated in the hygiene hypothesis. METHODS: Incident cases of MS or its precursor, clinically isolated syndrome (CIS), and matched controls (blacks, 111 cases/128 controls; Hispanics, 173/187; whites, 235/256) were recruited from the membership of Kaiser Permanente Southern California...
August 30, 2017: Neurology
https://www.readbyqxmd.com/read/28845389/ebv-driven-natural-killer-cell-disease-of-the-central-nervous-system-presenting-as-subacute-cognitive-decline
#7
Francesca M Brett, Richard Flavin, Daphne Chen, Teresa Loftus, Seamus Looby, Allan McCarthy, Cillian de Gascun, Elaine S Jaffe, Nurul Nor, Mohsen Javadpour, Dominick McCabe
Brain biopsy in patients presenting with subacute encephalopathyis never straightforward and only undertaken when a 'treatable condition' is a realistic possibility. This 63 year old right handed, immunocompetent Caucasian woman presented with an 8 month history of rapidly progressive right-sided hearing impairment, a 4 month history of intermittent headaches, tinnitus, 'dizziness', dysphagia, nausea and vomiting, with the subsequent evolution of progressive gait ataxia and a subacute global encephalopathy...
November 2017: Human Pathology (New York)
https://www.readbyqxmd.com/read/28761605/henoch-schonlein-purpura-associated-with-primary-active-epstein-barr-virus-infection-a-case-report
#8
Burcu Karakayali, Sila Yilmaz, Deniz Çakir, Pembe Gül Günes, Sirin Güven, Ismail Islek
Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. Various viral and bacterial infections, drugs, vaccines, food allergy and even insect bites have been considered as triggering factors in pathogenesis of HSP. Epstein-Barr virus (EBV) infection, which is associated with HSP, have been rarely reported. Herein we present HSP patient possibly caused by EBV infection. A 8-year old boy was admitted to our department with fever, rashes on legs and arms and intermittent mild abdominal pain...
2017: Pan African Medical Journal
https://www.readbyqxmd.com/read/28754665/multiparametric-detection-of-antibodies-against-different-ebv-antigens-to-predict-risk-for-nasopharyngeal-carcinoma-in-a-high-risk-population-of-china
#9
Hao Chen, Shulin Chen, Jie Lu, Xueping Wang, Jianpei Li, Linfang Li, Jihuan Fu, Thomas Scheper, Wolfgang Meyer, Yu-Hui Peng, Wanli Liu
In this study, we aimed to use the combined detection of multiple antibodies against Epstein-Barr virus (EBV) antigens to develop a model for screening and diagnosis of nasopharyngeal carcinoma (NPC). Samples of 300 nasopharyngeal carcinoma patients and 494 controls, including 294 healthy subjects (HC), 99 non-nasopharyngeal carcinoma cancer patients (NNPC), and 101 patients with benign nasopharyngeal lesions (BNL), were incubated with the EUROLINE Anti-EBV Profile 2, and band intensities were used to establish a risk prediction model...
July 28, 2017: Cancer Prevention Research
https://www.readbyqxmd.com/read/28734074/association-of-clinical-and-serological-parameters-of-systemic-lupus-erythematosus-patients-with-epstein-barr-virus-antibody-profile
#10
Chougule D, Nadkar M, Rajadhyaksha A, Pandit P, Surve P, Dawkar N, Khadilkar P, Patwardhan M, Kaveri Sv, Ghosh K, Pradhan V
Epstein-Barr viral infection is one of the known environmental factors involved in development of Systemic Lupus Erythematous (SLE). Though not much is known about the exact role of EBV in SLE pathogenesis, the theory of switching of lytic and lysogenic cycles of Epstein-Barr virus in memory B-cells fits well with the periods of waning disease activity and intermittent flares in SLE patients. In this study, we investigate the association of EBV antibody profile with clinical and serological parameters in SLE...
July 22, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28731372/exploring-the-effect-of-vitamin-d3-supplementation-on-the-anti-ebv-antibody-response-in-relapsing-remitting-multiple-sclerosis
#11
Linda Rolf, Anne-Hilde Muris, Amandine Mathias, Renaud Du Pasquier, Inga Koneczny, Giulio Disanto, Jens Kuhle, Sreeram Ramagopalan, Jan Damoiseaux, Joost Smolders, Raymond Hupperts
BACKGROUND: Epstein-Barr virus (EBV) infection and vitamin D insufficiency are potentially interacting risk factors for multiple sclerosis (MS). OBJECTIVES: To investigate the effect of high-dose vitamin D3 supplements on antibody levels against the EBV nuclear antigen-1 (EBNA-1) in patients with relapsing-remitting multiple sclerosis (RRMS) and to explore any underlying mechanism affecting anti-EBNA-1 antibody levels. METHODS: This study utilized blood samples from a randomized controlled trial in RRMS patients receiving either vitamin D3 (14,000 IU/day; n = 30) or placebo ( n = 23) over 48 weeks...
July 1, 2017: Multiple Sclerosis: Clinical and Laboratory Research
https://www.readbyqxmd.com/read/28670888/molecular-screening-for-epstein-barr-virus-ebv-detection-of-genomic-ebna-1-ebna-2-lmp-1-lmp-2-among-vietnamese-patients-with-nasopharyngeal-brush-samples
#12
Thuan Duc Lao, Dung Huu Nguyen, Trong Minh Nguyen, Thuy Ai Huyen Le
Epstein-Bar virus (EBV) is considered to be intimately associated with development of nasopharyngeal carcinoma (NPC), the most common and high incidence cancer of the head and neck in Asian countries, especially in Vietnam. In this study, we validated associations between highly conserved segments of the EBV genome, including EBNA-1, EBNA-2, LMP-1, LMP-2 and nasopharyngeal cancer, with the aim of applications with non-invasive brush samples for early diagnosis and as a prognostic biomarker. The polymerase chain reaction (PCR) was performed to assess the presence of EBNA-1, EBNA-2, LMP-1, LMP-2 in nasopharyngeal brush samples from Vietnamese NPC patients and non-cancer controls...
June 25, 2017: Asian Pacific Journal of Cancer Prevention: APJCP
https://www.readbyqxmd.com/read/28661055/evaluation-the-architect-ebv-vca-igm-vca-igg-and-ebna-1-igg-chemiluminescent-immunoassays-to-assess-ebv-serostatus-prior-transplantation
#13
Sarah Maylin, Linda Feghoul, Maud Salmona, Adel Herda, Séverine Mercier-Delarue, François Simon, Jérôme Legoff
Prior to transplantation of hematopoietic stem cells or solid organ, donor and recipient EBV serostatus has to be determined to assess risks of post-transplant lymphoproliferative disorders. Sensitivity of EBV Viral capsid antigens (VCA) IgG and EBV nuclear antigen-1 (EBNA-1) is critical to define past infection and a good specificity of VCA IgM is required to avoid any disqualification of cord blood (CB) units. Architect™ EBV antibody panel (Architect assay) providing a high throughput was compared to a semi-automated ELISA (Etimax assays Diasorin) to assess sensitivities and specificities of VCA and EBNA-1 IgG and VCA IgM on 419 sera collected from immunocompromised patients (n = 184) and from pregnant women who agreed to give CB cells (n = 235)...
June 29, 2017: Journal of Medical Virology
https://www.readbyqxmd.com/read/28644134/the-conundrum-of-the-epstein-barr-virus-associated-gastric-carcinoma-in-the-americas
#14
REVIEW
Gonzalo Carrasco-Avino, Ismael Riquelme, Oslando Padilla, Miguel Villaseca, Francisco R Aguayo, Alejandro H Corvalan
Epstein-Barr virus-associated gastric carcinoma shows a higher prevalence in the Americas than Asia. We summarize all studies of Epstein Barr virus-associated gastric carcinoma in the Americas, focusing on host characteristics, environmental associations and phylogeographic diversity of Epstein-Barr virus strains. In the Americas, the prevalence of Epstein Barr virus-associated gastric carcinoma is 11.4%, more frequent in males and portray predominantly diffuse-type histology. EBERs, EBNAs, BARTs and LMP are the highest expressed genes; their variations in healthy individuals may explain the phylogeographic diversity of Epstein-Barr virus across the region...
June 15, 2017: Oncotarget
https://www.readbyqxmd.com/read/28604802/serological-profiling-of-the-ebv-immune-response-in-chronic-fatigue-syndrome-using-a-peptide-microarray
#15
Madlen Loebel, Maren Eckey, Franziska Sotzny, Elisabeth Hahn, Sandra Bauer, Patricia Grabowski, Johannes Zerweck, Pavlo Holenya, Leif G Hanitsch, Kirsten Wittke, Peter Borchmann, Jens-Ulrich Rüffer, Falk Hiepe, Klemens Ruprecht, Uta Behrends, Carola Meindl, Hans-Dieter Volk, Ulf Reimer, Carmen Scheibenbogen
BACKGROUND: Epstein-Barr-Virus (EBV) plays an important role as trigger or cofactor for various autoimmune diseases. In a subset of patients with Chronic Fatigue Syndrome (CFS) disease starts with infectious mononucleosis as late primary EBV-infection, whereby altered levels of EBV-specific antibodies can be observed in another subset of patients. METHODS: We performed a comprehensive mapping of the IgG response against EBV comparing 50 healthy controls with 92 CFS patients using a microarray platform...
2017: PloS One
https://www.readbyqxmd.com/read/28578749/differential-prevalence-and-correlates-of-whole-blood-epstein-barr-virus-dna-between-hiv-positive-and-hiv-negative-men-who-have-sex-with-men-in-shanghai-china
#16
R Pan, X Liu, S Zhou, Z Ning, H Zheng, M Gao, Y Ding, W Yao, X Liao, N He
This cross-sectional study aimed to examine and compare prevalence and correlates of whole blood Epstein-Barr virus (EBV) DNA between HIV-positive and HIV-negative men who have sex with men (MSM). Five hundred and four HIV-positive MSM and 504 age-matched HIV-negative MSM were recruited from an HIV counseling and testing clinic in Shanghai, China from November 2014 to November 2015 and were administered with a face-to-face questionnaire interview. Whole blood EBV DNA was tested by nested polymerase chain reaction assays on EBNA-1, EBNA-2, and LMP-1 genes...
August 2017: Epidemiology and Infection
https://www.readbyqxmd.com/read/28572837/serum-ebv-antibodies-and-lmp-1-in-polish-patients-with-oropharyngeal-and-laryngeal-cancer
#17
Sylwia Fołtyn, Małgorzata Strycharz-Dudziak, Bartłomiej Drop, Anastazja Boguszewska, Małgorzata Polz-Dacewicz
BACKGROUND: The association between Epstein-Barr virus (EBV) and the development of head and neck cancer was reported by many researchers. The aim of the present study was to detect EBV DNA and EBV antibodies in 110 Polish patients with oropharyngeal and laryngeal cancer compared to 40 healthy individuals. METHODS: Frozen tumor tissue fragments were tested using nested PCR assay for EBV DNA detection. Sera from all individuals were investigated using ELISA tests to detect the presence of VCA IgM and IgG, EBNA IgG, EA IgG...
2017: Infectious Agents and Cancer
https://www.readbyqxmd.com/read/28465156/plasma-viral-mirnas-indicate-a-high-prevalence-of-occult-viral-infections
#18
Enrique Fuentes-Mattei, Dana Elena Giza, Masayoshi Shimizu, Cristina Ivan, John T Manning, Stefan Tudor, Maria Ciccone, Osman Aykan Kargin, Xinna Zhang, Pilar Mur, Nayra Soares do Amaral, Meng Chen, Jeffrey J Tarrand, Florea Lupu, Alessandra Ferrajoli, Michael J Keating, Catalin Vasilescu, Sai-Ching Jim Yeung, George A Calin
Prevalence of Kaposi sarcoma-associated herpesvirus (KSHV/HHV-8) varies greatly in different populations. We hypothesized that the actual prevalence of KSHV/HHV8 infection in humans is underestimated by the currently available serological tests. We analyzed four independent patient cohorts with post-surgical or post-chemotherapy sepsis, chronic lymphocytic leukemia and post-surgical patients with abdominal surgical interventions. Levels of specific KSHV-encoded miRNAs were measured by reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and KSHV/HHV-8 IgG were measured by immunoassay...
June 2017: EBioMedicine
https://www.readbyqxmd.com/read/28462850/epstein-barr-virus-infection-and-breast-invasive-ductal-carcinoma-in-egyptian-women-a-single-center-experience
#19
Noha Ed Hassab El-Naby, Hameda Hassan Mohamed, Asmaa Mohamed Goda, Ahmed El Sayed Mohamed
BACKGROUND: A controversy of the role of Epstein-Barr virus (EBV) infection in breast carcinomas has been reported in the literature. OBJECTIVES: We carried on this research to explore possible association between EBV infection and breast invasive ductal carcinoma (IDC) in Egyptian women attending our center. STUDY DESIGN: This study carried out at Sohag university hospital on 84 paraffin embedded samples of breast tissue, of them 42 breast IDC as the case group and 42 breast fibroadenomas as the control group...
April 24, 2017: Journal of the Egyptian National Cancer Institute
https://www.readbyqxmd.com/read/28395748/generation-of-induced-pluripotent-stem-cells-from-peripheral-blood-cd34-hematopoietic-progenitors-of-a-31year-old-healthy-woman
#20
Amornrat Tangprasittipap, Bunyada Jittorntrum, Wasinee Wongkummool, Narisorn Kitiyanant, Alisa Tubsuwan
The MUi019-A human induced pluripotent stem cell line was generated from peripheral blood CD34+ hematopoietic progenitors of a healthy woman using a non-integrative reprogramming method. Episomal vectors carrying reprogramming factors OCT4, SOX2, KLF4, L-MYC, LIN28, and shRNA of TP53 and EBNA-1 were delivered using electroporation. The iPSC line can be used as a control in studying disease mechanisms. Furthermore, gene editing approaches can be used to introduce specific mutations into the MUi019-A to model disease while the cell type affected by the disease is inaccessible...
April 2017: Stem Cell Research
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