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Thyroxine, pregnancy, iodine

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https://www.readbyqxmd.com/read/29760680/disruption-in-thyroid-signaling-pathway-a-mechanism-for-the-effect-of-endocrine-disrupting-chemicals-on-child-neurodevelopment
#1
REVIEW
Akhgar Ghassabian, Leonardo Trasande
Thyroid hormones are crucial in normal brain development. Transient and mild thyroid hormone insufficiency in pregnancy is also associated with impaired neurodevelopment in the offspring (e.g., 3-4 IQ score loss in association with maternal free thyroxine in the lowest fifth percentile). While inadequate iodine intake remains the most common underlying cause of mild thyroid hormone insufficiency in vulnerable populations including pregnant women, other factors such as exposure to environmental contaminants have recently attracted increasing attention, in particular in interaction with iodine deficiency...
2018: Frontiers in Endocrinology
https://www.readbyqxmd.com/read/29757392/thyroid-function-in-early-pregnancy-child-iq-and-autistic-traits-a-meta-analysis-of-individual-participant-data
#2
Deborah Levie, Tim I M Korevaar, Sarah C Bath, Albert Dalmau-Bueno, Mario Murcia, Mercedes Espada, Mariana Dineva, Jesús M Ibarluzea, Jordi Sunyer, Henning Tiemeier, Marisa Rebagliato, Margaret P Rayman, Robin P Peeters, Mònica Guxens
Context: Low maternal free thyroxine (FT4) has been associated with poor child neurodevelopment in some single-centre studies. Evidence remains scarce for potential adverse effects of high FT4 and whether associations differ in countries with a different iodine status. Objective: To assess the association of maternal thyroid function in early pregnancy with child neurodevelopment in countries with a different iodine status. Design, Setting and Participants: Meta-analysis of individual-participant data compromising 9,036 mother-child pairs from three prospective population-based birth cohorts: INMA (Spain), Generation R (The Netherlands) and ALSPAC (United Kingdom)...
May 10, 2018: Journal of Clinical Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29569122/impact-of-maternal-thyroid-autoantibodies-positivity-on-the-risk-of-early-term-birth-ma-anshan-birth-cohort-study
#3
Yan Han, Lei-Jing Mao, Xing Ge, Kun Huang, Shuang-Qin Yan, Ling-Ling Ren, Shu-Qing Hong, Hui Gao, Jie Sheng, Yuan-Yuan Xu, Wei-Jun Pan, Peng Zhu, Jia-Hu Hao, De-Fa Zhu, Fang-Biao Tao
PURPOSE: We aim to investigate associations of maternal serum anti-thyroperoxidase autoantibody (TPOAb) with duration of gestation. We aim to investigate whether maternal TPOAb positivity is associated with the risk of premature or early term birth. METHODS: This was a prospective birth cohort study performed in an iodine sufficient area of China. Serum samples were collected from 2931 women at both the first and second trimesters of pregnancy. Thyrotropin (TSH), free thyroxine (FT4), and TPOAb levels were measured...
May 2018: Endocrine
https://www.readbyqxmd.com/read/29535929/a-systematic-review-on-normative-values-of-trimester-specific-thyroid-function-tests-in-indian-women
#4
Subramanian Kannan, Shriraam Mahadevan, Alben Sigamani
Background: Small cross-sectional studies are published on the trimester-specific normal ranges of thyrotropin and thyroxine levels in Indian women from various parts of the country. Objective: We sought to review the published literature on thyroid function tests in normal pregnant Indian women to see if the pooled data from various studies can define normative data and hypothyroidism in pregnancy. Methods: We retrieved 56 studies from online databases with detailed search using multiple search terms...
January 2018: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/29529424/iodine-deficiency-in-pregnancy-still-a-health-issue-for-the-women-of-cassino-city-italy
#5
Chiara Tuccilli, Enke Baldini, Elia Truppa, Bruno D'Auria, Domenico De Quattro, Giovanni Cacciola, Tommaso Aceti, Giovanni Cirillo, Antonio Faiola, Patrizia Indigeno, Lorella D'Aliesio, Fiorella Gazzellone, Marco Bononi, Eleonora D'Armiento, Giovanni Carbotta, Daniele Pironi, Antonio Catania, Salvatore Sorrenti, Salvatore Ulisse
OBJECTIVE: The World Health Organization, the United Nations Children's Fund, and the International Council for the Control of Iodine Deficiency Disorders recommend a median urinary iodine concentration (UIC) in pregnant women between 150 µg/L and 249 µg/L. In the present study, we evaluated whether in the urban area of Cassino (central Italy), after a national salt iodination program (30 mg/kg) was introduced in 2005, the increased demand of iodine during pregnancy was satisfied...
June 2018: Nutrition
https://www.readbyqxmd.com/read/29337034/establishment-of-trimester-specific-reference-range-for-thyroid-hormones-during-pregnancy
#6
Sima Nazarpour, Fahimeh Ramezani Tehrani, Masoumeh Simbar, Sonia Minooee, Maryam Rahmati, Mohammad Ali Mansournia, Fereidoun Azizi
OBJECTIVE: Physiological gestational changes are associated with alterations in thyroid function which require different biochemical interpretation from that of non-pregnant women and necessitate established pregnancy-specific reference ranges. We aimed to identify the trimester-specific ranges of thyroid markers in a healthy population of pregnant Iranian women. METHODS: In this self-sequential study, data were extracted from The Tehran Thyroid and Pregnancy Study; a total of 314 women were tested during the 1st, 2nd and 3rd trimesters for serum levels of thyrotropin (TSH), thyroxine (T4), free thyroxine index (FT4I) and thyroid peroxidase antibody (TPOAb)...
March 2018: Clinical Biochemistry
https://www.readbyqxmd.com/read/29142837/preoperative-management-in-patients-with-graves-disease
#7
REVIEW
Eliana Piantanida
Graves' disease is the most frequent cause of hyperthyroidism in iodine-sufficient geographical areas and is characterized by the presence in patients' serum of autoantibodies directed against the thyrotropin receptor (TRAb) that cause overproduction and release of thyroid hormones. Clinical presentation results from both hyperthyroidism and underlying autoimmunity. The diagnosis is based on characteristic clinical features and biochemical abnormalities. If serum thyrotropin (TSH) is low, serum free thyroxine (FT4) and free triiodothyronine (FT3) concentrations should be measured to distinguish between subclinical (with normal circulating thyroid hormones) and overt hyperthyroidism (with increased circulating thyroid hormones)...
October 2017: Gland Surgery
https://www.readbyqxmd.com/read/29016579/iodine-and-thyroid-function-status-and-anti-thyroid-peroxidase-antibody-among-pregnant-women-in-eastern-nepal
#8
Lalit Narayan Chaudhary, Saroj Khatiwada, Basanta Gelal, Sharad Gautam, Madhab Lamsal, Hanoon Pokharel, Nirmal Baral
BACKGROUND: Iodine deficiency, thyroid dysfunction and development of thyroid autoimmunity during pregnancy may affect mother and the developing fetus. This study was carried out to find iodine status, thyroid dysfunction and thyroid autoimmunity among pregnant women. METHODS: Ninety two pregnant women from three districts of eastern Nepal (Sunsari, Morang and Jhapa) were enrolled for the study, and urine and blood samples were collected. Urinary iodine concentration (UIC), free thyroxine (free T4), thyroid stimulating hormone (TSH), thyroglobulin and anti-thyroid peroxidase (TPO) antibody levels were estimated...
September 8, 2017: Journal of Nepal Health Research Council
https://www.readbyqxmd.com/read/28770411/effect-of-iodine-nutrition-on-pregnancy-outcomes-in-an-iodine-sufficient-area-in-china
#9
Yue Xiao, Huakun Sun, Chenyan Li, Yongze Li, Shiqiao Peng, Chenling Fan, Weiping Teng, Zhongyan Shan
Many studies focused on the association between thyroid disease and pregnancy outcomes. The present study explored the effect of iodine nutrition during the first trimester on pregnancy outcomes. One thousand five hundred sixty-nine pregnant, euthyroid women at ≤12 weeks of gestation in an iodine-sufficient area in China were recruited. According to the World Health Organization (WHO) criteria for iodine nutrition during pregnancy, participants were divided into four groups: adequate iodine (median urinary iodine concentration (UIC), 150-249 μg/L), mild deficiency (UIC, 100-150 μg/L), moderate and severe deficiency (UIC, <100 μg/L), and more than adequate and excessive (UIC, ≥250 μg/L) groups...
April 2018: Biological Trace Element Research
https://www.readbyqxmd.com/read/28620499/intrauterine-death-following-intraamniotic-triiodothyronine-and-thyroxine-therapy-for-fetal-goitrous-hypothyroidism-associated-with-polyhydramnios-and-caused-by-a-thyroglobulin-mutation
#10
Pradeep Vasudevan, Corrina Powell, Adeline K Nicholas, Ian Scudamore, James Greening, Soo-Mi Park, Nadia Schoenmakers
In the absence of maternal thyroid disease or iodine deficiency, fetal goitre is rare and usually attributable to dyshormonogenesis, for which genetic ascertainment is not always undertaken in the UK. Mechanical complications include tracheal and oesophageal compression with resultant polyhydramnios, malpresentation at delivery and neonatal respiratory distress. We report an Indian kindred in which the proband (first-born son) had congenital hypothyroidism (CH) without obvious neonatal goitre. His mother's second pregnancy was complicated by fetal hypothyroid goitre and polyhydramnios, prompting amniotic fluid drainage and intraamniotic therapy (with liothyronine, T3 and levothyroxine, T4)...
2017: Endocrinology, Diabetes & Metabolism Case Reports
https://www.readbyqxmd.com/read/28409122/a-post-publication-analysis-of-the-idealized-upper-reference-value-of-2-5%C3%A2-miu-l-for-tsh-time-to-support-the-thyroid-axis-with-magnesium-and-iron-especially-in-the-setting-of-reproduction-medicine
#11
Roy Moncayo, Helga Moncayo
Laboratory medicine approaches the evaluation of thyroid function mostly through the single determination of the blood level of thyroid stimulating hormone (TSH). Some authors have suggested an upper reference value for TSH of 2.5 mIU/L. This suggestion has not been confirmed by recent clinical studies. These studies have delivered a clinically valid reference range going from 0.3 to 3.5 mIU/L. These values are valid for both for the general population as well as in the setting of fertility and pregnancy...
June 2017: BBA Clinical
https://www.readbyqxmd.com/read/28333271/impact-of-thyroid-autoimmunity-in-euthyroid-women-on-live-birth-rate-after-iui
#12
D Unuane, B Velkeniers, B Bravenboer, P Drakopoulos, H Tournaye, J Parra, M De Brucker
Study question: Does thyroid autoimmunity (TAI) predict live birth rate in euthyroid women after one treatment cycle in IUI patients? Summary answer: TAI as such does not influence pregnancy outcome after IUI treatment. What is known already: The role of TAI on pregnancy outcome in the case of IVF/ICSI is largely debated in the literature. This is the first study to address this issue in the case of IUI. Study design, size, duration: This was a retrospective cohort study...
April 1, 2017: Human Reproduction
https://www.readbyqxmd.com/read/28212640/urinary-iodine-in-early-pregnancy-is-associated-with-subclinical-hypothyroidism-in-tianjin-china-an-observational-study
#13
Kunling Wang, Jie Zhang, Fengao Li, Wanqi Zhang, Hao Wang, Li Ding, Yaxin Liu, Laixiang Lin, Shuang Zhang, Mei Zhu
BACKGROUND: Subclinical hypothyroidism (SH) is associated with adverse obstetric outcomes and neurodevelopment disorders. Both iodine deficiency and excess are associated with SH; however, few data regarding iodine nutrition status of pregnant women with SH are available. This study aimed to clarify whether iodine deficiency or excess is associated with SH, especially, when test results for anti-thyroid autoantibodies are negative. METHODS: A total of 115 women with SH and 104 women with euthyroidism (EH) in early pregnancy in Tianjin, China were investigated, and their serum thyroid-stimulating hormone, free thyroxine, free triiodothyronine, anti-thyroid peroxidase antibody (TPOAb), anti-thyroid globulin antibody (TGAb), urinary iodine (UIC), and urinary creatinine (UCr) concentrations were measured...
February 17, 2017: BMC Endocrine Disorders
https://www.readbyqxmd.com/read/28171716/reference-intervals-of-thyroid-hormones-during-pregnancy-in-korea-an-iodine-replete-area
#14
Hye Jeong Kim, Yoon Young Cho, Sun Wook Kim, Tae Hyuk Kim, Hye Won Jang, Soo-Youn Lee, Suk-Joo Choi, Cheong-Rae Roh, Jong-Hwa Kim, Jae Hoon Chung, Soo-Young Oh
BACKGROUND/AIMS: Maternal thyroid dysfunction has been associated with adverse pregnancy outcomes. The purpose of our study was to establish trimester-specific reference intervals for thyroid hormones in pregnant women in Korea, where iodine intake is more than adequate and to examine pregnancy and perinatal outcomes in their offspring. METHODS: Among 459 healthy pregnant women who were screened, we enrolled 417 subjects who had negative results for thyroid autoantibodies...
May 2018: Korean Journal of Internal Medicine
https://www.readbyqxmd.com/read/28126204/the-relationship-between-iron-level-and-thyroid-function-during-the-first-trimester-of-pregnancy-a-cross-sectional-study-in-wuxi-china
#15
Jinyan Fu, Anqiang Yang, Jun Zhao, Yunlong Zhu, Ying Gu, Yaohui Xu, Daozhen Chen
Our objective was to evaluate the relationship between iron level and thyroid function during the first trimester of pregnancy in Eastern China. This was a hospital-based, cross-sectional observational study. A total of 1764 pregnant women were enrolled during their first trimester of gestation in Wuxi city. Serum ferritin (SF), hemoglobin (Hb), urinary iodine concentrations (UIC), thyroid-stimulating hormone (TSH), free thyroxine (FT4) and free triiodothyronine (FT3) were measured and evaluated in pregnant women...
September 2017: Journal of Trace Elements in Medicine and Biology
https://www.readbyqxmd.com/read/27867885/trimester-specific-reference-interval-for-thyroid-hormones-during-pregnancy-at-a-tertiary-care-hospital-in-haryana-india
#16
Rajesh Rajput, Bhagat Singh, Vasudha Goel, Amit Verma, Shashi Seth, Smiti Nanda
BACKGROUND: Reference intervals for thyroid hormone during pregnancy need to be gestational age, method, and population specific and there is need to establish trimester-specific thyroid levels for the different population across the world. The aim of this study was to establish trimester-specific reference range for thyroid hormone during pregnancy in a tertiary care center in Haryana. MATERIALS AND METHODS: A total of 1430 pregnant women were recruited for the study...
November 2016: Indian Journal of Endocrinology and Metabolism
https://www.readbyqxmd.com/read/27818216/estimation-of-iodine-nutrition-and-thyroid-function-status-in-late-gestation-pregnant-women-in-the-united-states-development-and-application-of-a-population-based-pregnancy-model
#17
A Lumen, N I George
Previously, a deterministic biologically-based dose-response (BBDR) pregnancy model was developed to evaluate moderate thyroid axis disturbances with and without thyroid-active chemical exposure in a near-term pregnant woman and fetus. In the current study, the existing BBDR model was adapted to include a wider functional range of iodine nutrition, including more severe iodine deficiency conditions, and to incorporate empirically the effects of homeostatic mechanisms. The extended model was further developed into a population-based model and was constructed using a Monte Carlo-based probabilistic framework...
January 1, 2017: Toxicology and Applied Pharmacology
https://www.readbyqxmd.com/read/27733101/reference-intervals-of-thyroid-function-during-pregnancy-self-sequential-longitudinal-study-versus-cross-sectional-study
#18
Xiaomei Zhang, Baoting Yao, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Xiaochun Teng, Cheng Han, Weiwei Zhou, Chenyang Li, Bin Xu, Lihua Bi, Tao Meng, Jianling Du, Shaowei Zhang, Zhengnan Gao, Liu Yang, Chenling Fan, Weiping Teng, Zhongyan Shan
BACKGROUND: A self-sequential longitudinal reference interval may be expected to minimize the inter-individual variation of thyroid function. Comparison between the self-sequential longitudinal reference interval (SLRI) and cross-sectional reference interval (CSRI) in pregnancy has not been well investigated. The objectives of this study were to establish a stringent SLRI of thyroid function in pregnant women and to compare it with the conventional CSRI. METHODS: Three cohorts were enrolled: group 1, pregnant women for an SLRI (n = 99); group 2, pregnant women for a CSRI (n = 1318); group 3, non-pregnant control women (NC) as a control group (n = 301) according to the criteria of the National Academy of Clinical Biochemistry...
December 2016: Thyroid: Official Journal of the American Thyroid Association
https://www.readbyqxmd.com/read/27564693/thyroid-dysfunction-in-preterm-neonates-exposed-to-iodine
#19
Fiona L R Williams, Jennifer Watson, Chris Day, Aung Soe, Sateesh K Somisetty, Lesley Jackson, Elena Velten, Anita Boelen
BACKGROUND: Infants <32 weeks' gestation should not be exposed to topical iodine and its avoidance is recommended during pregnancy and breast feeding. Exposure to contrast media and topical iodine is frequently used in many preterm neonates. AIM: To determine whether thyrotropin levels in preterm infants are affected by exposure to intrapartum/neonatal topical iodine and/or the use of iodinated contrast media. DESIGN: Infants <32 weeks' gestation were recruited...
January 1, 2017: Journal of Perinatal Medicine
https://www.readbyqxmd.com/read/27519283/gestation-specific-changes-in-maternal-thyroglobulin-during-pregnancy-and-lactation-in-an-iodine-sufficient-region-in-china-a-longitudinal-study
#20
Xiaowen Zhang, Chenyan Li, Jinyuan Mao, Weiwei Wang, Xiaochen Xie, Shiqiao Peng, Zhaojun Wang, Cheng Han, Xiaomei Zhang, Danyang Wang, Chenling Fan, Zhongyan Shan, Weiping Teng
OBJECTIVES: To describe the changes in thyroglobulin (Tg) based upon gestational and postpartum concentrations in healthy pregnant women from an iodine-sufficient region in China, and to evaluate the use of Tg as a biomarker for iodine-sufficient pregnant women. DESIGN: A longitudinal study of Tg change in normal pregnant women from an iodine-sufficient region. PATIENTS AND MEASUREMENTS: Blood and urine samples were obtained from 133 pregnant women...
February 2017: Clinical Endocrinology
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