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Tatiana Pochechueva, Alexander Chinarev, Andreas Schoetzau, André Fedier, Nicolai V Bovin, Neville F Hacker, Francis Jacob, Viola Heinzelmann-Schwarz
Altered levels of naturally occurring anti-glycan antibodies (AGA) circulating in human blood plasma are found in different pathologies including cancer. Here the levels of AGA directed against 22 negatively charged (sialylated and sulfated) glycans were assessed in high-grade serous ovarian cancer (HGSOC, n = 22) patients and benign controls (n = 31) using our previously developed suspension glycan array (SGA). Specifically, the ability of AGA to differentiate between controls and HGSOC, the most common and aggressive type of ovarian cancer with a poor outcome was determined...
2016: PloS One
Ping Liang, Junling Li
BACKGROUND: Due to it's concealment and no obvious symptoms, lung squamous carcimoma often has advanced disease when diagnosed. The aims of this study were to describe the characteristics of the disease, to evaluate the clinical importance of detection of multiple tumor markers in patients with squamous cell carcinoma of the lung. METHODS: The characteristics of all patients with advanced squamous cell lung cancer treated in Beijing Cancer Hospital of Chinese Academy of Medical Sciences during Jan...
October 20, 2016: Zhongguo Fei Ai za Zhi, Chinese Journal of Lung Cancer
T Ni, X Sun, B Shan, J Wang, Y Liu, S-L Gu, Y-D Wang
OBJECTIVE: To evaluate the role of circulating tumour cells (CTCs) in patients with endometrial cancer (EC). STUDY DESIGN: This study included 40 patients with a pre-operative diagnosis of high-risk EC between April 2015 and May 2016. Patients were further divided into high-risk (grade 3, non-endometrioid, myometrial invasion ≥1/2 and stage III-IV) and high-intermediate-risk (grade 2-3, endometrioid, myometrial invasion <1/2 and stage I-II) groups according to postoperative pathological results...
October 10, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
Florian Kälble, Janine Damaske, Danijela Heide, Iris Arnold, Fabian Richter, Olaf Maier, Ulrich Eisel, Peter Scheurich, Klaus Pfizenmaier, Martin Zeier, Vedat Schwenger, Julia Ranzinger
Chronic inflammatory conditions during peritoneal dialysis (PD)-treatment lead to the impairment of peritoneal tissue integrity. The resulting structural and functional reorganization of the peritoneal membrane diminishes ultrafiltration rate and thereby enhances mortality by limiting dialysis effectiveness over time. Tumour necrosis factor (TNF) and its receptors TNFR1 and TNFR2 are key players during inflammatory processes. To date, the role of TNFR1 in peritoneal tissue damage during PD-treatment is completely undefined...
2016: PloS One
Ratko Delić, Mario Štefanović, Štefka Krivec, Vladimir Weber, Jakob Koren
OBJECTIVE: The aim of this study was to measure serum concentrations of human epididymis protein 4 (HE4) in premenopausal and postmenopausal women with benign adnexal tumors and compare HE4 levels with those of cancer antigen 125 (CA125) measured in the same samples. METHODS: In a retrospectively designed, monocentric study (Department of Gynecology & Obstetrics, General Hospital, Celje, Slovenia, EU), 147 women diagnosed with various benign adnexal tumors were included...
October 17, 2016: Wiener Klinische Wochenschrift
Ga Won Yim, Hee Jung Kim, Lee Kyung Kim, Sang Wun Kim, Sunghoon Kim, Eun Ji Nam, Young Tae Kim
Purpose: The biological function of long non-coding RNAs (lncRNAs) is only partially understood; therefore, in this study, we investigated the expression of the novel HOXA11 antisense (HOXA11as) lncRNA and its oncogenic role in serous ovarian cancer (SOC). Materials and Methods: HOXA11as expression was examined in 129 serous ovarian cancer tissue samples by real time RT-PCR. Clinicopathological factors and patient survival were compared between the high (N = 27) and low HOXA11as expression group (N = 102)...
October 11, 2016: Cancer Research and Treatment: Official Journal of Korean Cancer Association
Atsushi Yamamoto, Yoshiaki Miyasaka, Kazushige Furuya, Hideki Watanabe, Masahiro Maruyama, Haruka Nakada, Atsushi Takano, Masao Hada, Hiroshi Nakagomi, Masao Omata, Toshio Oyama
We herein experienced a case with pseudo-Meigs' syndrome that developed both synchronous and metachronous metastases to the ovary from ascending colon cancer. A 57-year-old female visited a hospital for a 2-month history of abdominal distension and voiding difficulty. Massive pleural effusion on the right side and a small amount of left-sided pleural effusion were detected on CT. She underwent emergent laparotomy due to the severe symptom of abdominal distention. The tumor originated from the left ovary, and left-sided oophorectomy was performed...
December 2016: Surgical Case Reports
Elisa Piovano, Camilla Cavallero, Luca Fuso, Elsa Viora, Annamaria Ferrero, Gianluca Gregori, Caterina Grillo, Chiara Macchi, Giulio Mengozzi, Marco Mitidieri, Eva Pagano, Paolo Zola
BACKGROUND: Transvaginal ultrasonography (TVS) and serum biomarkers are widely used in clinical practice to triage adnexal masses, but the effectiveness of current biomarkers is quite weak. OBJECTIVES: To determine the best way to diagnose the patients with adnexal masses, in terms of diagnostic accuracy and economic costs, among four triage strategies: International Ovarian Tumor Analysis group's simple rules (SR) for the interpretation of TVS with the addition of subjective assessment (SA) by an experienced ultrasound operator only when TVS results are inconclusive (hereafter defined as SR±SA), SR±SA+CA125, SR±SA+HE4, and SR±SA+ROMA...
October 5, 2016: Ultrasound in Obstetrics & Gynecology
An-Na Zhu, Ming-Fei Guan, Yan Zhu, Yan Li, Li Zhou, Cong-Zhu Li, Ping Huang
OBJECTIVE: To evaluate the clinicopathological characteristics, treatment and prognosis of uterine malignant mixed mullerian tumor. METHODS: The clinical, pathologic and follow-up data of 16 patients with uterine malignant mixed Mullerian tumor treated in our hospital between March, 2003 and June, 2015 were analyzed. RESULTS: The 16 patients had a median age of 58 years at diagnosis, and 13 of them were postmenopausal. The number of patients with FIGO stage Ia, Ib, II, IIIa, IIIc2, and IV was 7, 3, 1, 3, 1, and 1, respectively...
August 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Chuanxi Wang, Jinyu Yu, Yuping Han, Leping Li, Jie Li, Tao Li, Peng Qi
Colorectal cancer (CRC) is currently the most prevalent malignant cancer worldwide. However, there is a lack of efficient biomarkers for CRC screening. Accumulating evidence reveals that long non-coding RNAs (lncRNAs) detectable in serum are associated with the genesis and development of various types of cancer. Therefore, we examined the diagnostic ability of lncRNAs in blood samples from patients with CRC by evaluating the levels of 17 CRC- or gastrointestinal cancer-related lncRNAs in serum samples from 71 CRC patients and 70 healthy individuals using reverse transcription-quantitative polymerase chain reaction (RT-qPCR)...
September 23, 2016: Oncotarget
Aurélie Pelissier, Aurélie Roulot, Béatrice Guéry, Claire Bonneau, Dominique Bellet, Roman Rouzier
BACKGROUND: The aim of this study is to evaluate a new tumour marker, HE4, and to compare it with CA125 in predicting optimal cytoreduction and response to chemotherapy. Thirty patients with advanced epithelial ovarian cancer and multiple sera harvested during neoadjuvant chemotherapy (NAC) were included. RESULTS: Based on ROC curves analysis, CA125 ≤ 75 UI/ml and HE4 ≤ 252 pmol/L after the 3rd cycles of NAC, with a sensitivity of 93.7 % and a specificity of 92...
September 27, 2016: Journal of Ovarian Research
Nienke Zwakman, Rafli van de Laar, Toon Van Gorp, Petra L M Zusterzeel, Marc P M L Snijders, Isabel Ferreira, Leon F A G Massuger, Roy F P M Kruitwagen
OBJECTIVE: In patients with advanced stage epithelial ovarian cancer (EOC) the volume of residual tumor after debulking is known as prognostic factor for survival. We wanted to examine the relationship between postoperative decline in serum CA125 and residual disease after cytoreductive surgery and evaluate perioperative changes in serum CA125 levels as predictor for disease-specific survival. METHODS: A retrospective study was conducted of patients with FIGO stage IIb-IV EOC treated with cytoreductive surgery, followed by chemotherapy between 1996 and 2010 in three hospitals in the Southeastern region of the Netherlands...
September 12, 2016: Journal of Gynecologic Oncology
Tatiana De Los Ríos, Juan Pérez-Martínez, Jose Portoles, Monika Lichodziejewska-Niemierko, Maite Rivera, Michał Nowicki, Andrzej Książek, Ana María Tato, Christine Bohnhorst, Mariano Feriani
Interference of conventional peritoneal dialysis fluids (cPDFs) with peritoneal membrane cell functions may be attributed to the dialysis fluid's low pH, high glucose concentration, and/or the presence of glucose degradation products (GDPs), the last of which leads to higher levels of advanced glycation end-products (AGEs). It has been suggested that the peritoneal membrane might be better preserved by using biocompatible solutions, including cancer antigetn 125 (CA125). This prospective, open-label, multicentre, randomized, controlled, cross-over phase IV study compared the in vivo biocompatibility of a neutral-pH, low-GDP peritoneal dialysis (PD) solution (balance) with a cPDF in automated PD (APD) patients...
September 2016: Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis
Giannina Calongos, Mai Ogino, Takatoshi Kinuta, Masateru Hori, Tatsuo Mori
A 76-year-old female presented to our hospital with a 2 cm firm, nontender, protuberant umbilical nodule. She received treatment with antibiotics for suspected granuloma, with no improvement after two months. High levels of CA125 as well as an ovarian cyst and intrathoracic and intra-abdominal lesions on imaging studies made us suspect an ovarian cancer with a Sister Mary Joseph nodule (SMJN) and other metastases. A bilateral salpingo-oophorectomy and umbilical and omentum tumor resections were performed and a metastatic ovarian serous adenocarcinoma was diagnosed by histopathology...
2016: Case Reports in Obstetrics and Gynecology
Hai-Tao Wu, Xiao-Jun Yang, Chao-Qun Huang, Jian-Hua Sun, Zhong-He Ji, Kai-Wen Peng, Qian Zhang, Yan Li
BACKGROUND: This work was to evaluate the perioperative safety and efficacy of cytoreductive surgery (CRS) plus hyperthermic intraperitoneal chemotherapy (HIPEC) with lobaplatin and docetaxel in patients with peritoneal carcinomatosis (PC) from gastrointestinal and gynecological cancers. METHODS: Patients were treated by CRS + HIPEC with lobaplatin 50 mg/m(2) and docetaxel 60 mg/m(2) in 6000 mL of normal saline at 43 ± 0.5 °C for 60 min. Vital signs were recorded for 6 days after CRS + HIPEC procedures...
2016: World Journal of Surgical Oncology
Zhi-Jun Yang, Bing-Bing Zhao, Li Li
BACKGROUND: Ovarian cancer has the highest mortality rate of the three main malignant tumors of the female reproductive system, with a 5-year overall survival (OS) of only 20-30 %. Approximately 70 % of patients relapse without being cured. To explore the significance of serum CA125 level pre-treatment and the change pattern of CA125 post-treatment for judging prognosis and diagnosing recurrences of epithelial ovarian cancer (EOC). METHODS: A radioimmunoassay was used to continuously monitor levels of serum CA125 in 152 patients with EOC...
2016: Journal of Ovarian Research
Ying Shen, Li Li
Epithelial ovarian cancer (EOC) remains the deadliest form of gynecological cancers. Optimal tumor debulking, no matter the primary or the interval, is the most important prognostic factor for EOC, so there is an urgent demand for biomarkers to predict surgical outcome. The aim of this study was to investigate whether serum human epididymis protein 4 (HE4) and cancer antigen 125 (CA125) could predict surgical outcome of EOC. The levels of preoperative serum HE4 and CA125 were determined by electrochemiluminescence (ECLIA) in 82 EOC patients, comprising 39 subjected to primary debulking surgery (PDS) and 43 with extensive stage III or IV disease to neoadjuvant chemotherapy followed by interval debulking surgery (NACT-IDS)...
September 15, 2016: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
Burcu Kısa Karakaya, Eralp Başer, Berk Bildacı, Esra Çabuk Cömert, Nilufer Bayraktar, Polat Dursun, Esra Kuşçu, Ali Ayhan
OBJECTIVES: The aim of the study was to assess the usefulness of various tumor markers (CA125, HE4, bcl2) measured in serum, urine and saliva in the differential diagnosis of adnexal masses. MATERIAL AND METHODS: Our study was conducted at the Başkent University Medical School, Department of Obstetrics and Gynecology, Ankara, Turkey, between November 2010 and March 2011. Fifty patients with a suspicion of malignant adnexal mass and 30 controls were included in the study...
2016: Ginekologia Polska
Etsuko Miyagi, Yasuyo Maruyama, Tae Mogami, Reiko Numazaki, Atsuko Ikeda, Hiroshi Yamamoto, Fumiki Hirahara
BACKGROUND: We previously developed a new plasma amino acid profile-based index (API) to detect ovarian, cervical, and endometrial cancers. Here, we compared API to serum cancer antigen 125 (CA125) for distinguishing epithelial ovarian malignant tumors from benign growths. METHODS: API and CA125 were measured preoperatively in patients with ovarian tumors, which were later classified into 59 epithelial ovarian cancers, 21 epithelial borderline malignant tumors, and 97 benign tumors including 40 endometriotic cysts...
September 13, 2016: International Journal of Clinical Oncology
Oliver Husser, Julio Núñez, Christof Burgdorf, Andreas Holzamer, Christian Templin, Thorsten Kessler, Vicente Bodi, Juan Sanchis, Costanza Pellegrini, Andreas Luchner, Lars S Maier, Christof Schmid, Thomas F Lüscher, Heribert Schunkert, Adnan Kastrati, Michael Hilker, Christian Hengstenberg
INTRODUCTION AND OBJECTIVES: Conventional risk scores have not been accurate in predicting peri- and postprocedural risk of patients undergoing transcatheter aortic valve implantation (TAVI). Elevated levels of the tumor marker carbohydrate antigen 125 (CA125) have been linked to adverse outcomes after TAVI. We studied the additional value of CA125 to that of the EuroSCORE in predicting long-term mortality after TAVI. METHODS AND RESULTS: During a median follow-up of 59 weeks, 115 of 422 patients (27%) died after TAVI...
September 9, 2016: Revista Española de Cardiología
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