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https://www.readbyqxmd.com/read/28639753/screening-for-ovarian-cancer-imaging-challenges-and-opportunities-for-improvement
#1
EDITORIAL
Kelsey B Mathieu, Deepak G Bedi, Sara L Thrower, Aliya Qayyum, Robert C Bast
The United Kingdom Collaborative Trial of Ovarian Cancer Screening (UKCTOCS) recently reported a reduction in the average overall mortality among ovarian cancer patients screened with an annual sequential, multimodal strategy that tracked biomarker CA125 over time, where increasing serum CA125 levels prompted ultrasound. However, multiple cases were documented wherein serum CA125 levels were rising, but ultrasound screens were normal, thus delaying surgical intervention. A significant factor which could contribute to false negatives is that many aggressive ovarian cancers are believed to arise from epithelial cells on the fimbriae of the fallopian tubes, which are not readily imaged...
June 22, 2017: Ultrasound in Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28639570/menorrhagia-and-uterine-volume-associated-with-lower-urinary-tract-symptoms-in-patients-with-adenomyosis
#2
Ting Li, Xiao-Xuan Xu, Yi Dai, Jun-Ji Zhang, Jing-He Lang, Jin-Hua Leng
BACKGROUND: Adenomyosis is a gynecological disorder with symptoms most presenting as dysmenorrhea and heavy menstrual bleeding. However, the presence of lower urinary tract symptoms (LUTS) among women with adenomyosis remains unclear. This study was designed to determine the prevalence of LUTS and factors related to the severity of these symptoms in this population. METHODS: From July 2016 to November 2016, a total of 298 untreated symptomatic adenomyosis patients and 280 age-matched controls were enrolled...
July 5, 2017: Chinese Medical Journal
https://www.readbyqxmd.com/read/28638252/evaluation-of-the-ki-67-proliferation-index-and-urocortin-expression-in-women-with-ovarian-endometriomas
#3
Serenat Eris Yalcin, Irfan Ocal, Yakup Yalcin, Halime Sen Selim, Melike Demir Caltekin, Huseyin Aydogmus, Sefa Kelekci
OBJECTIVE: The reasons why endometriosis is more aggressive and invasive in some patients are unknown. Despite the importance of population-based clinically defined risk factors in the prediction of recurrence, biochemical markers obtained from the patient are more valuable for prediction on an individual basis. Therefore, the discovery of significant potential biomarkers could be useful to clinicians for shedding light on the pathogenesis of endometriosis and in the monitoring recurrence...
June 2017: Eurasian Journal of Medicine
https://www.readbyqxmd.com/read/28637689/elevation-of-tp53-autoantibody-prior-to-ca125-in-preclinical-invasive-epithelial-ovarian-cancer
#4
Wei-Lei Yang, Aleksandra Gentry-Maharaj, Archana R Simmons, Andy Ryan, Evangelia O Fourkala, Zhen Lu, Keith A Baggerly, Yang Zhao, Karen Lu, David D L Bowtell, Ian Jacobs, Steven J Skates, Wei-Wu He, Usha Menon, Robert C Bast
Purpose: The TP53 tumor suppressor gene is mutated in >95% of high grade serous ovarian cancers. Detecting an autologous antibody response to TP53 might improve early detection. <p>Experimental design: An immunoassay was developed to measure TP53 autoantibody in sera from 378 cases of invasive epithelial ovarian cancer and in 944 age-matched healthy controls from the United States, Australia and the United Kingdom. Serial preclinical samples from cases and controls were also assayed from the UK Collaborative Trial of Ovarian Cancer Screening (UKCTOCS)...
June 21, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28637006/the-effect-of-ca125-on-metastasis-of-ovarian-cancer-old-marker-new-function
#5
Qin Yuan, Jiayin Song, Weiwei Yang, Hongyan Wang, Qianyu Huo, Jie Yang, Xiaoxu Yu, Yunde Liu, Chen Xu, Huijing Bao
CA125 has been used extensively to screen for neoplasms, especially in ovarian cancer. The serum CA125 level can be used as a better prognosis evaluation and it may dynamic monitoring the disease progression. We explored the effect of CA125 on ovarian cancer cell migration and its underlying mechanism. Transwell assays showed that exposure to 0.2 μg/ml or 0.4 μg/ml CA125 for 48 h increased migration of A2780 and OVCAR-3 ovarian cancer cells. This effect of CA125 was blocked addition of 200 ng/ml DKK-1, a Wnt pathway inhibitor...
June 7, 2017: Oncotarget
https://www.readbyqxmd.com/read/28624692/preoperative-serum-levels-of-ykl-40-and-ca125-as-a-prognostic-indicators-in-patients-with-endometrial-cancer
#6
Beata Kotowicz, Malgorzata Fuksiewicz, Joanna Jonska-Gmyrek, Michal Wagrodzki, Maria Kowalska
OBJECTIVE: To evaluate the utility of YKL-40 and CA125 in endometrial cancer (EC) patients, and to determine their prognostic value in assessing the disease-free survival (DFS) and overall survival (OS). METHODS: We analyzed seventy-four EC patients, treated at a single institution and 25 healthy individuals. CA 125 serum level was evaluated in the Cobas 6000 system and YKL-40, using the ELISA method. RESULTS: Significantly increased serum level of YKL-40 and CA125 was in EC patients in FIGO I-IB when compared to healthy controls...
June 13, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28623900/characterization-of-microrna-200-pathway-in-ovarian-cancer-and-serous-intraepithelial-carcinoma-of-fallopian-tube
#7
Junzheng Yang, Yilan Zhou, Shu-Kay Ng, Kuan-Chun Huang, Xiaoyan Ni, Pui-Wah Choi, Kathleen Hasselblatt, Michael G Muto, William R Welch, Ross S Berkowitz, Shu-Wing Ng
BACKGROUND: Ovarian cancer is the leading cause of death among gynecologic diseases in Western countries. We have previously identified a miR-200-E-cadherin axis that plays an important role in ovarian inclusion cyst formation and tumor invasion. The purpose of this study was to determine if the miR-200 pathway is involved in the early stages of ovarian cancer pathogenesis by studying the expression levels of the pathway components in a panel of clinical ovarian tissues, and fallopian tube tissues harboring serous tubal intraepithelial carcinomas (STICs), a suggested precursor lesion for high-grade serous tumors...
June 17, 2017: BMC Cancer
https://www.readbyqxmd.com/read/28607926/the-combination-of-the-tumor-markers-suggests-the-histological-diagnosis-of-lung-cancer
#8
Linjie Liu, Jinlong Teng, Lijun Zhang, Peishan Cong, Yuan Yao, Guirong Sun, Zhijun Liu, Teng Yu, Mingjun Liu
Tumor markers are beneficial for the diagnosis and therapy monitoring of lung cancer. However, the value of tumor markers in lung cancer histological diagnosis is unknown. In this study, we analyzed the serum levels of six tumor markers (CEA, CYFRA21-1, SCC, NSE, ProGRP, and CA125) in 2097 suspected patients with lung cancer and determined whether the combination of the tumor markers was useful for histological diagnosis of lung cancer. We found that CYFRA21-1 was the most sensitive marker in NSCLC. ProGRP showed a better clinical performance than that of NSE in discriminating between SCLC and NSCLC...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28604456/urinary-polyamines-as-biomarkers-for-ovarian-cancer
#9
Riikka Johanna Niemi, Antti N Roine, Merja R Häkkinen, Pekka S Kumpulainen, Tuomo A Keinänen, Jouko J Vepsäläinen, Terho Lehtimäki, Niku K Oksala, Johanna U Mäenpää
OBJECTIVES: Elevated concentrations of polyamines have been found in urine of patients with malignant tumors, including ovarian cancer. Previous research has suffered from poorly standardized detection methods. Our liquid chromatography-tandem mass spectrometry (LC-MS/MS) method is capable of simultaneous standardized analysis of most known polyamines. Liquid chromatography-tandem mass spectrometry has not previously been used in the differential diagnostics of ovarian tumors in postmenopausal women...
June 10, 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28600055/recurrent-female-adnexal-tumor-of-probably-wolffian-origin-a-case-report
#10
Tian Qiu, Yincheng Teng, Jianqian Tong, Wenqi Tao, Liang Xu
OBJECTIVE: Wolffian adnexal tumors (WATs) are rare, and metastasis is uncommon. We present the case of a 53-year-old female with a recurrent WAT. CASE REPORT: The patient presented with abdominal distension, and ultrasound revealed heterogeneous echoes (130 × 93 × 116 mm(3)) around the uterus and ascites. Her cancer antigen 125 (CA125) and CA19-9 levels were elevated. Hysterectomy, bilateral oophorectomy, and tumor resection were performed. The histopathological diagnosis was a WAT...
June 2017: Taiwanese Journal of Obstetrics & Gynecology
https://www.readbyqxmd.com/read/28597474/zeb1-expression-is-a-potential-indicator-of-invasive-endometriosis
#11
Masataka Furuya, Hirotaka Masuda, Kanako Hara, Hiroshi Uchida, Kenji Sato, Suguru Sato, Hironori Asada, Tetsuo Maruyama, Yasunori Yoshimura, Hidetaka Katabuchi, Mamoru Tanaka, Hideyuki Saya
INTRODUCTION: Although endometriosis is a benign disease, it shares some features with cancers, such as invasiveness and the potential to metastasize. This study sought to investigate the epithelial-mesenchymal transition (EMT) status in human endometriotic lesions. MATERIAL AND METHODS: Thirteen endometriosis patients and ten control women without endometriosis undergoing surgery for benign indications were recruited. We examined the expression of E-cadherin, vimentin, and EMT-induced transcriptional factors, such as Snail and ZEB1, by immunohistochemistry...
June 8, 2017: Acta Obstetricia et Gynecologica Scandinavica
https://www.readbyqxmd.com/read/28588323/impact-of-body-mass-index-on-ovarian-cancer-survival-varies-by-stage
#12
Elisa V Bandera, Valerie S Lee, Bo Qin, Lorna Rodriguez-Rodriguez, C Bethan Powell, Lawrence H Kushi
BACKGROUND: Research on the effect of body mass index (BMI) on ovarian cancer survival is inconsistent, but previous studies did not consider the possible impact of ascites, bowel obstruction, or cachexia, which commonly occur in late-stage disease. METHODS: We evaluated the association of BMI, before and around the time of diagnosis, with overall and disease-specific survival in a cohort study of primary invasive epithelial ovarian cancers diagnosed from 2000 to 2013 in Kaiser Permanente Northern California (KPNC) (n=1184)...
June 6, 2017: British Journal of Cancer
https://www.readbyqxmd.com/read/28582844/postoperative-recurrence-analysis-of-breast-cancer-patients-based-on-clinical-serum-markers-using-discriminant-methods
#13
Lu Li, Qilong Gao, Guolin Xu, Bian Shi, Xuhui Ma, Huaimin Liu, Qiujian Li, Tongde Tian, Jingwen Tang, Hong Niu
BACKGROUND: Breast cancer is a common gynecological malignant tumor and currently its clinical diagnosis mainly depends on methods of iconography and measurement of serum level. OBJECTIVE: To analyze correlation between serum index levels and prognosis of patients with breast cancer in one week and six months after operation, and to establish support vector machine (SVM) model to evaluate its effectiveness. METHODS: One hundred sixty eight patients diagnosed with breast cancer at Henan Cancer Hospital were collected, 46 of which did palindromia while other 122 didn't six months after operation...
May 19, 2017: Cancer Biomarkers: Section A of Disease Markers
https://www.readbyqxmd.com/read/28578489/downregulation-of-lncrna-tuba4b-is-associated-with-poor-prognosis-for-epithelial-ovarian-cancer
#14
Fang-Fang Zhu, Fei-Yun Zheng, Hai-Ou Wang, Jing-Jie Zheng, Qian Zhang
A host of studies have revealed that long non-coding RNAs (lncRNAs) are critically involved in the development and progression of epithelial ovarian cancer. LncRNA TUBA4B is recently identified to be a critical mediator in non-small cell lung cancer. However, the clinical roles and biological functions of lncRNA TUBA4B in epithelial ovarian cancer have yet to be fully clarified. The present study was conducted to explore the expression of lncRNA TUBA4B in human epithelial ovarian cancer tissues and potential roles of lncRNA TUBA4B in ovarian cancer cells...
June 3, 2017: Pathology Oncology Research: POR
https://www.readbyqxmd.com/read/28571024/elevated-preoperative-ca125-or-ca19-9-in-borderline-ovarian-tumors-could-it-be-suggestive-of-advanced-stage-or-a-poor-prognosis
#15
Taejong Song, Doo Haeng Lee, Yong Wook Jung, Bo Seong Yun, Seok Ju Seong, Chel Hun Choi, Jeong-Won Lee, Duk-Soo Bae, Byoung-Gie Kim
OBJECTIVES: To investigate whether elevated levels of CA125 (≥35 U/mL) and CA19-9 (≥37 U/mL) suggest advanced-stage disease (defined as stage II or higher) or poor prognosis in patients with borderline ovarian tumors (BOTs). STUDY DESIGN: We retrospectively identified 591 patients with BOTs. Multivariate logistic regressions and Cox proportional hazard regressions were used to determine the clinicopathologic factors associated with the presence of advanced-stage disease and the prognostic factors associated with recurrence-free survival...
June 2, 2017: Gynecologic and Obstetric Investigation
https://www.readbyqxmd.com/read/28549976/brca-mutational-status-initial-disease-presentation-and-clinical-outcome-in-high-grade-serous-advanced-ovarian-cancer-a-multicenter-study
#16
Marco Petrillo, Claudia Marchetti, Rossella De Leo, Angela Musella, Ettore Capoluongo, Ida Paris, Pierluigi Benedetti Panici, Giovanni Scambia, Anna Fagotti
BACKGROUND: In the last decades, there have been several efforts to clarify the role of BRCA mutational status in women with advanced ovarian cancer, demonstrating its role in cancer development, as well as the prognostic significance of BRCA genotype. OBJECTIVE: Our aim is to evaluate the correlation between BRCA mutational status and disease presentation in a large series of advanced high-grade serous ovarian cancer patients. STUDY DESIGN: This is a retrospective multicenter study including a consecutive series of newly diagnosed high-grade serous ovarian cancer patients with International Federation of Gynecology and Obstetrics stage IIIC-IV disease, at least 18 months of follow-up time, and tested for BRCA 1/2 germline mutation status...
May 23, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28544260/hysteroscopic-excision-of-symptomatic-myometrial-adenomyosis-feasibility-and-effectiveness
#17
W Xia, D Zhang, Q Zhu, H Zhang, S Yang, J Ma, H Pan, T Tong, J Sun, J Zhang
OBJECTIVE: To explore the feasibility and efficacy of hysteroscopic excision of myometrial adenomyotic lesions. DESIGN: A case-series study. SETTING: A university medical centre. POPULATION: 51 women with myometrial adenomyosis completed the study. METHODS: The patients underwent hysteroscopic excision of myometrial adenomyosis and were followed up for 24 months. The degree of symptoms, uterine volume, and serum CA125 concentrations were recorded...
May 19, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28539285/-diagnostic-value-of-ca125-he4-and-copenhagen-index-in-differentiating-benign-from-malignant-epithelial-ovarian-tumors
#18
Shi-Peng Gong, Yong-Ning Chen, Ya-di Zhang, Wei Yao, Li Chen, Shi-San Liu, Huan Wu
OBJECTIVE: To analyze diagnostic value of Copenhagen Index based on pretreatment serum CA125, HE4 and age in differentiating benign and malignant epithelial ovarian tumors. METHODS: The clinical data were analyzed for 208 consecutive patients with epithelial ovarian tumors (including 100 with malignant and 108 with benign tumors) treated in our department between September, 2014 and September, 2016. The receiver-operating characteristic curve was drawn based on the golden standard of pathological diagnosis for calculation of the diagnostic sensitivity and specificity of CA125, HE4 and the Copenhagen Index...
May 20, 2017: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
https://www.readbyqxmd.com/read/28535427/far-infrared-ray-fir-therapy-an-effective-and-oncological-safe-treatment-modality-for-breast-cancer-related-lymphedema
#19
Ke Li, Liang Xia, Ning Fei Liu, Fabio Nicoli, Joannis Constantinides, Christopher D'Ambrosia, Davide Lazzeri, Mathias Tremp, Ju Fang Zhang, Yi Xin Zhang
BACKGROUND: The incidence of breast cancer related lymphedema is approximately 5%. Far infrared ray (FIR) treatment can potentially reduce fluid volume and extremity circumference as well as the frequency of dermato-lymphangitis (DLA). However, there is no published data on the oncological safety of FIR and the potential for activation of any residual breast cancer cells. The aim of this study is to investigate the safety of far infrared ray (FIR) treatment of postmastectomy lymphedema, clinically and in vitro...
July 2017: Journal of Photochemistry and Photobiology. B, Biology
https://www.readbyqxmd.com/read/28534379/dosimetry-study-on-radioactive-particle-brachytherapy-in-oral-carcinoma
#20
Zhang Jie, Meng Jian, Zhuang Qianwei, Li Zhiping
PURPOSE: To investigate the therapeutic effects of different doses of (125)I radioactive particle brachytherapy on oral cancer. METHODS: Between September 2012 and September 2015, 78 patients with oral cancer who received (125)I radioactive particle brachytherapy for the first time in our hospital were enrolled in this study. Patients were divided into high dose (≥3) and low dose (<3) groups. The treatment outcome, serum tumor marker levels and the expression levels of autophagy and apoptotic genes in tumor cells were compared between groups...
March 2017: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
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