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https://www.readbyqxmd.com/read/28078870/assessing-the-association-between-25-oh-vitamin-d-levels-and-roma-score-in-a-population-of-obese-women
#1
E Anastasi, D Capoccia, T Granato, V Viggiani, S Tartaglione, L Manganaro, A Angeloni, F Leonetti
The “Risk of Malignancy Algorithm” (ROMA) combines the diagnostic power of the CA125 and HE4 markers with menopausal status to predict the risk for developing epithelial ovarian cancer (EOC). The aim of this study was to evaluate the association between 25-OH vitamin D levels and ROMA score in obese women. One hundred and eighteen patients with a Body Mass Index (BMI) > 30 kg/m2 (Group 1) and 80 women with a BMI less than 25 kg / m² (Group 2) were studied. The 25-OH vitamin D was quantified with LUMIPULSE® G 1200...
October 2016: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28075407/diagnostic-value-of-serum-angiogenesis-markers-in-ovarian-cancer-using-multiplex-immunoassay
#2
Agnieszka Horala, Agata Swiatly, Jan Matysiak, Paulina Banach, Ewa Nowak-Markwitz, Zenon J Kokot
As cancer development involves pathological vessel formation, 16 angiogenesis markers were evaluated as potential ovarian cancer (OC) biomarkers. Blood samples collected from 172 patients were divided based on histopathological result: OC (n = 38), borderline ovarian tumours (n = 6), non-malignant ovarian tumours (n = 62), healthy controls (n = 50) and 16 patients were excluded. Sixteen angiogenesis markers were measured using BioPlex Pro Human Cancer Biomarker Panel 1 immunoassay. Additionally, concentrations of cancer antigen 125 (CA125) and human epididymis protein 4 (HE4) were measured in patients with adnexal masses using electrochemiluminescence immunoassay...
January 10, 2017: International Journal of Molecular Sciences
https://www.readbyqxmd.com/read/28071629/clinical-characteristics-with-patterns-of-relapse-and-survival-analysis-of-ovarian-clear-cell-carcinoma
#3
S Kaur, R A Kerkar, A Maheshwari, T S Shylasree, S Gupta, K Deodhar
AIMS: To analyze clinical characteristics, patterns of relapse, and treatment outcomes of clearcell carcinoma of the ovary (CCO). MATERIALS AND METHODS: Case files of 51 patients diagnosed with CCO between 2003 and 2010 were reviewed. RESULTS: The median age at diagnosis was 48 years (27-64 years). Fifty percent presented with nonspecific gastrointestinal symptoms. The median serum Ca125 was 74 IU/ml (6-1567 U/ml). Optimal cytoreduction was achieved in 32 (62...
April 2016: Indian Journal of Cancer
https://www.readbyqxmd.com/read/28062115/genotype-matched-treatment-for-patients-with-advanced-type-i-epithelial-ovarian-cancer-eoc
#4
A Spreafico, A M Oza, B A Clarke, H J Mackay, P Shaw, M Butler, N C Dhani, S Lheureux, M K Wilson, S Welch, T Zhang, C Yu, T Stockley, L L Siu, S Kamel-Reid, P L Bedard
BACKGROUND: Genomic alterations that activate the MAPK signaling pathway frequently occur in Type I Epithelial Ovarian Cancers (EOCs). We evaluated therapeutic response outcomes in patients with type I EOC treated with genotype-matched therapy on clinical trials enrolled in a prospective molecular profiling program. MATERIAL AND METHODS: Formalin fixed paraffin embedded tumor tissues were prospectively screened for genomic alterations using MALDI-ToF mass-spectrometry platform or targeted sequencing using the Illumina MiSeq TruSeq Amplicon Cancer Panel...
January 3, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/28057126/-value-of-using-gonadotropin-releasing-hormone-agonist-pretreatment-in-adenomyosis-patients-before-adenomyomectomy
#5
A L Tan, R Y Luo, M Gong
Objective: To investigate the value of using gonadotropin-releasing hormone agonist (GnRH-a) pretreatment in adenomyosis patients before adenomyomectomy. Methods: From May 2012 to September 2015, 87 patients with adenomyosis who were non-effective to conservative therapy in Renmin Hospital of Wuhan University were enrolled in this study. According to the principle of randomized control, 41 patients were in the treatment group who were treated with GnRH-a 2-3 cycles before adenomyomectomy, while 46 patients in the control group...
December 25, 2016: Zhonghua Fu Chan Ke za Zhi
https://www.readbyqxmd.com/read/28053931/combined-evaluation-of-afp-ca15-3-ca125-ca19-9-and-cea-tumor-markers-in-patients-with-hepatitis-b-and-c
#6
Mehdi Assmar, Sara Yeganeh, Fariborz Mansourghanaei, Nour Amirmozafari
BACKGROUND: This study aimed to determine the role of tumor markers AFP, CA15-3, CA125, CA19-9 and CEA in patients with hepatitis B and C. METHODS: This descriptive cross-sectional study was performed from Oct 2012 to Oct 2014. Serum samples of 129 patients with hepatitis B and C referred to Guilan Liver and Digestive Disease Research Center in Rasht, Iran were collected and checked for the existence of the listed tumor markers by ELISA. RESULTS: No increase in serum levels of tumor marker CA19-9, CEA and CA15-3 were seen in patients with hepatitis (P>0...
December 2016: Iranian Journal of Public Health
https://www.readbyqxmd.com/read/28051260/the-application-value-of-the-detection-of-the-level-of-tissue-polypeptide-antigen-ovarian-cancer-antigen-x1-cathepsin-l-and-ca125-on-the-diagnosis-of-epithelial-ovarian-cancer
#7
X-L Lv, Y Zhu, J-W Liu, H Ai
OBJECTIVE: We investigated the value of the joint detection of tissue polypeptide antigen (TPA), ovarian cancer antigen X1 (OVX1), cathepsin L (CTSL) and CA125 on the early diagnosis of epithelial ovarian carcinoma (EOC). PATIENTS AND METHODS: From October 2011 to February 2015, 84 cases of patients under surgical treatment of epithelial ovarian cancer, 98 cases of patients with benign epithelial ovarian tumor and 51 subjects in healthy control group were selected to detect the level of TPA, OVX1 and CTSL in serum from the Obstetrics and Gynecology Department of the First Affiliated Hospital of Liaoning Medical University...
December 2016: European Review for Medical and Pharmacological Sciences
https://www.readbyqxmd.com/read/28050675/predictors-of-pretreatment-ca125-at-ovarian-cancer-diagnosis-a-pooled-analysis-in-the-ovarian-cancer-association-consortium
#8
Ana Babic, Daniel W Cramer, Linda E Kelemen, Martin Köbel, Helen Steed, Penelope M Webb, Sharon E Johnatty, Anna deFazio, Diether Lambrechts, Marc T Goodman, Florian Heitz, Keitaro Matsuo, Satoyo Hosono, Beth Y Karlan, Allan Jensen, Susanne K Kjær, Ellen L Goode, Tanja Pejovic, Melissa Moffitt, Estrid Høgdall, Claus Høgdall, Iain McNeish, Kathryn L Terry
PURPOSE: Cancer antigen 125 (CA125) is a glycoprotein expressed by epithelial cells of several normal tissue types and overexpressed by several epithelial cancers. Serum CA125 levels are mostly used as an aid in the diagnosis of ovarian cancer patients, to monitor response to treatment and detect cancer recurrence. Besides tumor characteristics, CA125 levels are also influenced by several epidemiologic factors, such as age, parity, and oral contraceptive use. Identifying factors that influence CA125 levels in ovarian cancer patients could aid in the interpretation of CA125 values for individuals...
January 3, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28039713/value-of-circulating-tumor-cells-positive-for-thyroid-transcription-factor-1-ttf-1-to-predict-recurrence-and-survival-rates-for-endometrial-carcinoma
#9
Yan Zhang, Xin Qu, Peng Peng Qu
PURPOSE: This study was conducted to analyze the predictive value of circulating tumor cells (CTC) expressing thyroid transcription factor-1 (TTF-1) on the recurrence and survival rates of endometrial carcinoma patients treated with laparoscopic surgery. METHODS: 78 patients were recruited, diagnosed with endometrial carcinoma and measured CTC expressing TTF-1 using flow cytometry in blood and tissues. Then, the patients were distributed into TTF-1-positive (N=42) and -negative (N=36) groups...
November 2016: Journal of B.U.ON.: Official Journal of the Balkan Union of Oncology
https://www.readbyqxmd.com/read/28033255/primarily-isolated-hepatic-involvement-of-amyloidosis-a-case-report-and-overview
#10
Lei Ye, Hui Shi, Hui-Min Wu, Fang-Yu Wang
BACKGROUND: Amyloidosis is particularly difficult to diagnose because the signs and symptoms are subtle. Additionally, there are no specific imaging or laboratory tests, except histopathology. Although it is considered to be a systemic disorder, a small portion of cases may be localized. INTRODUCTION OF THE CASE: A 54-year-old man presented with nonspecific symptoms (jaundice and back pruritus). Biochemical tests showed a high level of bilirubin and elevated serum tumor markers (CA19-9 and CA125)...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/28018110/preoperative-evaluation-of-pancreatic-ductal-adenocarcinoma-with-synchronous-liver-metastasis-diagnosis-and-assessment-of-unresectability
#11
Hao-Jun Shi, Chen Jin, De-Liang Fu
AIM: To identify predictors for synchronous liver metastasis from resectable pancreatic ductal adenocarcinoma (PDAC) and assess unresectability of synchronous liver metastasis. METHODS: Retrospective records of PDAC patients with synchronous liver metastasis who underwent simultaneous resections of primary PDAC and synchronous liver metastasis, or palliative surgical bypass, were collected from 2007 to 2015. A series of pre-operative clinical parameters, including tumor markers and inflammation-based indices, were analyzed by logistic regression to figure out predictive factors and assess unresectability of synchronous liver metastasis...
December 7, 2016: World Journal of Gastroenterology: WJG
https://www.readbyqxmd.com/read/28011514/clinical-performance-of-cea-ca19-9-ca15-3-ca125-and-afp-in-gastrointestinal-cancer-using-loci%C3%A2-based-assays
#12
Ramona C Dolscheid-Pommerich, Steffen Manekeller, Gisela Walgenbach-Brünagel, Jörg C Kalff, Gunther Hartmann, Birgit Stoffel Wagner, Stefan Holdenrieder
BACKGROUND/AIM: Few data are available regarding the clinical performance of LOCI™-based tumor marker assays. We investigated the diagnostic power of carcinogenic antigen, carbohydrate antigen 19-9, carbohydrate antigen 15-3, carbohydrate antigen 125 and alpha-fetoprotein for detection of gastrointestinal (GI) cancer. PATIENTS AND METHODS: We analyzed sera from 204 patients (107 with GI cancer, 73 with benign GI diseases and 24 healthy controls) using the Dimension™ Vista1500 analyzer...
January 2017: Anticancer Research
https://www.readbyqxmd.com/read/28008574/use-of-tumor-markers-in-gastrointestinal-cancers-surgeon-perceptions-and-cost-benefit-trade-off-analysis
#13
REVIEW
Amish Acharya, Sheraz R Markar, Michael Matar, Melody Ni, George B Hanna
BACKGROUND: Gastrointestinal cancers constitute the third most common cancers worldwide. Tumor markers have long since been used in the postoperative surveillance of these malignancies; however, the true value in clinical practice remains undetermined. OBJECTIVE: This study aimed to evaluate the clinical utility of three tumor markers in colorectal and esophagogastric cancer. METHODS: A systematic review of the literature was undertaken to elicit the sensitivity, specificity, statistical heterogeneity and ability to predict recurrence and metastases for carcinoembryonic antigen (CEA), cancer antigen (CA) 19-9 and CA125...
December 22, 2016: Annals of Surgical Oncology
https://www.readbyqxmd.com/read/28008424/correlation-of-ca-125-serum-level-and-clinico-pathological-characteristic-of-patients-with-endometriosis
#14
Mojgan Karimi-Zarchi, Najmeh Dehshiri-Zadeh, Leili Sekhavat, Fahime Nosouhi
BACKGROUND: Cancer antigen 125 (CA-125) is a glycoprotein biomarker that is used in women with pelvic masses such as endometriosis and maybe is useful in practice of patients suspicious to endometriosis. OBJECTIVE: The aim of this study was to evaluate the association between preoperative serum CA-125 levels and clinic pathological characteristic in women with endometriosis, and find out the best serum CA-125 levels cut-off in pre and post menopause women. MATERIALS AND METHODS: Serum CA-125 levels in 87 women aged 21-54 years suspected to endometriosis with pelvic pain, dysmenorrhea, or dyspareunia were measured preoperatively...
November 2016: International Journal of Reproductive Biomedicine (Yazd, Iran)
https://www.readbyqxmd.com/read/28008196/clinical-characteristics-of-primary-peritoneal-carcinoma-patients-a-single-institution-experience-involving-8-patients
#15
Satomi Hattori, Hiroaki Kajiyama, Utako Fuji, Yuko Furui, Yuki Ishibashi, Yuka Hattori, Noriko Takahashi, Fumitaka Kikkawa, Toshiya Misawa
Primary peritoneal carcinoma (PPC) is treated similarly to advanced epithelial ovarian carcinoma (aEOC); however, the standard approach for the management of PPC is controversial. The objective of this study was to evaluate the clinical features and prognosis of those patients. A retrospective analysis was performed of eight patients with PPC between January 2008 and December 2015. Clinicopathologic parameters, the diagnostic modality, treatment, and oncologic outcome were analyzed. The median age at the time of diagnosis was 72...
December 2016: Nagoya Journal of Medical Science
https://www.readbyqxmd.com/read/28002320/ca125-is-a-potential-biomarker-to-predict-surgically-incurable-gastric-and-cardia-cancer-a-retrospective-study
#16
Taobo Luo, Wenhu Chen, Lifang Wang, Hongguang Zhao
Preoperative evaluation of the curability of gastric and cardia cancer is important to avoid risks of unnecessary surgery. Our previous study has reported several clinical parameters associated with incurable gastric surgery. In this study, we aimed to evaluate the correlation between CA125 and the curability of gastric and cardia cancer.A total of 297 cases of gastric and cardia cancer were analyzed retrospectively, including 153 cases with radical surgery and 144 with surgery for incurable gastric or cardia cancer...
December 2016: Medicine (Baltimore)
https://www.readbyqxmd.com/read/27994671/reduction-of-ca125-levels-during-neoadjuvant-chemotherapy-can-predict-cytoreduction-to-no-visible-residual-disease-in-patients-with-advanced-epithelial-ovarian-cancer-primary-carcinoma-of-fallopian-tube-and-peritoneal-carcinoma
#17
Jing Zeng, Jie Yin, Xiao Song, Ying Jin, Yan Li, Lingya Pan
Background and aims. To determine whether reduction of CA125 levels is a predictive factor for cytoreduction to no visible residual disease (NVRD) and chemotherapeutic sensitivity in advanced epithelial ovarian carcinoma (EOC), primary carcinoma of fallopian tube and peritoneal carcinoma patients who received neoadjuvant chemotherapy followed by interval debulking surgery (NAC-IDS). Methods. This was a single-team-based study of advanced EOC, primary carcinoma of fallopian tube and peritoneal carcinoma patients diagnosed between 1996 and 2015 at Peking Union Medical College Hospital...
2016: Journal of Cancer
https://www.readbyqxmd.com/read/27992377/improved-clinical-outcomes-of-patients-with-ovarian-carcinoma-arising-in-endometriosis
#18
Jiaqi Lu, Xiang Tao, Jiayi Zhou, Yingying Lu, Zehua Wang, Haiou Liu, Congjian Xu
BACKGROUND: Despite enormous efforts to dissect the role of endometriosis in ovarian cancer development, the difference in prognosis between ovarian cancer patients with or without endometriosis remains elusive. The purpose of this study is to assess the association between endometriosis and the prognosis in patients with ovarian cancer. RESULTS: Ovarian cancer arising in endometriosis tended to be presented as clear cell histology, early stage, less intraperitoneal metastasis and ascites, and lower CA125 level compared with those without endometriosis...
December 15, 2016: Oncotarget
https://www.readbyqxmd.com/read/27987404/diagnostic-accuracy-of-cancer-antigen-125-ca125-for-endometriosis-in-symptomatic-women-a-multi-center-study
#19
Martin Hirsch, James M N Duffy, Christine S Deguara, Colin J Davis, Khalid S Khan
STUDY OBJECTIVE: To assess the diagnostic accuracy of serum Cancer Antigen 125 (CA 125)≥30units/milliliter (u/ml) for diagnosing endometriosis in symptomatic women. STUDY DESIGN: Prospective observational cohort study including patients with symptoms of pelvic pain or subfertility undergoing elective diagnostic laparoscopy at two tertiary referral hospitals. We excluded patients suspected to have other gynecological pathology. We evaluated the accuracy of serum CA 125 (index test) with histologically confirmed endometriosis (reference standard)...
December 5, 2016: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/27980523/assessment-of-levels-of-the-tumor-markers-he4-and-ca125-considering-staging-grading-and-histological-types-of-endometrial-cancer
#20
Nabil Abdalla, Robert Piórkowski, Paweł Stanirowski, Anna Słomka, Krzysztof Cendrowski, Włodzimierz Sawicki
AIM OF THE STUDY: Aim of the study was to assess statistical differences of serum levels of HE4 and CA125 between certain endometrial cancer stages, grading and histological types. MATERIAL AND METHODS: A retrospective study of 52 patients admitted to our clinic for a surgical operation because of endometrial cancer was performed. HE4 and CA125 were measured for each patient. The staging was done according to FIGO. The statistical difference of serum levels of tumor markers was analyzed considering different stages, grading and histological types...
November 2016: Przeglad Menopauzalny, Menopause Review
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