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https://www.readbyqxmd.com/read/29332643/role-of-laparoscopy-in-diagnosing-genital-tuberculosis-in-suspected-women-a-cross-sectional-study-from-a-tertiary-care-hospital-in-northern-india
#1
Y M Mala, Ruchi Prasad, Nilanchali Singh, C P Baweja, Reva Tripathi, Niharika Yedla
This study was included 60 women with suspected genital tuberculosis, attending outpatient department of a tertiary care hospital. The aim was to evaluate the role and accuracy of laparoscopy in the diagnosis of genital tuberculosis. The patients were investigated for tuberculosis with Erythrocyte Sedimentation Rate, Montoux, chest X-ray, serum ELISA, CA125, ultrasonography, endometrial biopsy and laparoscopic biopsy. Culture or histopathology was taken as a gold standard for confirming the cases of genital tuberculosis...
January 2018: Indian Journal of Tuberculosis
https://www.readbyqxmd.com/read/29325350/-the-current-status-of-diagnosis-and-treatment-of-pancreatic-cystic-neoplasm-in-china-a-report-of-2-251-cases
#2
(no author information available yet)
Objective: To analyze the current status of diagnosis and treatment of pancreatic cystic neoplasm(PCN)in China. Methods: Clinical data of 2 251 PCN patients who underwent surgical resection from January 2006 to December 2016 in 16 institutions was retrospectively analyzed.Excel database was created which covered 132 fields of 7 fields: general information of patients, imaging findings, preoperative blood biochemical indexes, tumor markers, surgical related data, postoperative complications and pathology. Results: Of the 2 251 patients, the male to female ratio was 1...
January 1, 2018: Zhonghua Wai Ke za Zhi [Chinese Journal of Surgery]
https://www.readbyqxmd.com/read/29306485/comparison-of-carbohydrate-antigen-125-and-n-terminal-pro-brain-natriuretic-peptide-for-risk-prediction-after-transcatheter-aortic-valve-implantation
#3
Tobias Rheude, Costanza Pellegrini, Hans Schmid, Teresa Trenkwalder, N Patrick Mayr, Michael Joner, Albert M Kasel, Stefan Holdenrieder, Julio Nunez, Juan Sanchis, Vicent Bodi, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
Elevated carbohydrate antigen 125 (CA125) and N-terminal pro-brain natriuretic peptide (NTproBNP) have been associated with adverse outcome after transcatheter aortic valve implantation (TAVI). This study performs a comparison of both biomarkers for prognosis after TAVI. The study includes 363 patients. The primary end point was all-cause death or readmission for worsening congestive heart failure within 1 year after TAVI, and this end point occurred in 16% of the population. The optimal cutoff to predict the primary end point was 18...
November 27, 2017: American Journal of Cardiology
https://www.readbyqxmd.com/read/29306434/focused-glycomic-profiling-with-an-integrated-microfluidic-lectin-barcode-system
#4
Yuqin Shang, Yong Zeng
Protein glycosylation is one of the key processes that play essential roles in biological functions and dysfunctions. However, progress in glycomics has considerably lagged behind genomics and proteomics, due in part to the enormous challenges associated with the analysis of glycans. Here we present a new integrated and automated microfluidic lectin barcode platform to substantially improve the performance of lectin array for focused glycomic profiling. The chip design and flow control were optimized to promote the lectin-glycan binding kinetics and the speed of lectin microarrays...
2018: Methods in Enzymology
https://www.readbyqxmd.com/read/29304854/suitability-assessment-of-baseline-concentration-of-mmp3-timp3-he4-and-ca125-in-the-serum-of-patients-with-ovarian-cancer
#5
Aneta Cymbaluk-Płoska, Anita Chudecka-Głaz, Ewa Pius-Sadowska, Bogusław Machaliński, Janusz Menkiszak, Agnieszka Sompolska-Rzechuła
BACKGROUND: MMP and TIMP play an important role in the degradation of extracellular matrix components which are essential for tumor growth, invasion and metastasis. Aim of this research was to assess MMP3 and TIMP3 as prognostic factors among patients with ovarian cancer. RESULTS: It was found that high levels of output MMP3 correlated with shortened overall survival time of patients by 9.7 months. In addition, it has been shown that high concentrations of output MMP3 were significantly associated with a shorter disease free time in median concentrations implemented p = 0...
January 5, 2018: Journal of Ovarian Research
https://www.readbyqxmd.com/read/29297708/determinants-of-elevated-carbohydrate-antigen-125-in-patients-with-severe-symptomatic-aortic-valve-stenosis-referred-for-transcatheter-aortic-valve-implantation
#6
Tobias Rheude, Costanza Pellegrini, Wibke Reinhard, Teresa Trenkwalder, Wolfgang Koenig, N Patrick Mayr, Michael Joner, Julio Núñez, Stefan Holdenrieder, Heribert Schunkert, Adnan Kastrati, Christian Hengstenberg, Oliver Husser
PURPOSE: Elevated carbohydrate antigen 125 (CA125) predicts adverse outcome after transcatheter aortic valve implantation (TAVI). While known underlying pathophysiological mechanisms of elevated CA125 include serosal effusions and inflammatory stimuli, clinical determinants associated with elevated CA125 in patients referred for TAVI remain unknown. Therefore, we investigated clinical, laboratory and echocardiographic determinants of elevated CA125 in patients with severe aortic valve stenosis referred for TAVI...
January 3, 2018: Biomarkers: Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals
https://www.readbyqxmd.com/read/29296235/adjustment-of-serum-he4-to-reduced-glomerular-filtration-and-its-use-in-biomarker-based-prediction-of-deep-myometrial-invasion-in-endometrial-cancer
#7
Josef Chovanec, Iveta Selingerova, Kristina Greplova, Sofie Leisby Antonsen, Monika Nalezinska, Claus Høgdall, Estrid Høgdall, Erik Søgaard-Andersen, Kirsten M Jochumsen, Pavel Fabian, Dalibor Valik, Lenka Zdrazilova-Dubska
Background: We investigated the efficacy of circulating biomarkers together with histological grade and age to predict deep myometrial invasion (dMI) in endometrial cancer patients. Methods: HE4ren was developed adjusting HE4 serum levels towards decreased glomerular filtration rate as quantified by the eGFR-EPI formula. Preoperative HE4, HE4ren, CA125, age, and grade were evaluated in the context of perioperative depth of myometrial invasion in endometrial cancer (EC) patients...
December 8, 2017: Oncotarget
https://www.readbyqxmd.com/read/29290489/the-utility-of-sentinel-lymph-node-mapping-in-the-management-of-endometrial-atypical-hyperplasia
#8
Omar Touhami, Jean Grégoire, Marie-Claude Renaud, Alexandra Sebastianelli, Katherine Grondin, Marie Plante
OBJECTIVES: To determine the risk of endometrial cancer (EC) and lymph node involvement in patients with a preoperative diagnosis of "AH-only" versus "AH - cannot rule out carcinoma" and to study the value of SLN mapping. METHODS: We reviewed all patients with a preoperative diagnosis of atypical hyperplasia, who underwent primary surgery with SLN mapping followed by pelvic lymphadenectomy. Sensitivity and negative predictive value (NPV) of SLN and rates of endometrial cancer were calculated...
December 28, 2017: Gynecologic Oncology
https://www.readbyqxmd.com/read/29289320/ultrasensitive-flexible-fet-type-aptasensor-for-ca-125-cancer-marker-detection-based-on-carboxylated-multiwalled-carbon-nanotubes-immobilized-onto-reduced-graphene-oxide-film
#9
Samira Mansouri Majd, Abdollah Salimi
The development of a novel flexible and ultrasensitive aptasensor based on carboxylated multiwalled carbon nanotubes (MWCNTs)/ reduced graphene oxide-based field effect transistor (FET) has been reported for label-free detection of the ovarian cancer antigen (CA125). The fabricated sensor has a straightforward design based on the noncovalent attachment of MWCNTs/aptamer conjugated onto few layers reduced graphene oxide nanosheets and its integration with poly-methyl methacrylate (PMMA) as a suitable platform for designing flexible field-effect transistors...
February 13, 2018: Analytica Chimica Acta
https://www.readbyqxmd.com/read/29282264/comparing-the-diagnostic-accuracy-of-five-common-tumour-biomarkers-and-ca19-9-for-pancreatic-cancer-a-protocol-for-a-network-meta-analysis-of-diagnostic-test-accuracy
#10
Long Ge, Bei Pan, Fujian Song, Jichun Ma, Dena Zeraatkar, Jianguo Zhou, Jinhui Tian
INTRODUCTION: Surgical resection is the only curative treatment for patients with resectable pancreatic cancer. Unfortunately, 80%-85% of patients present with locally advanced or metastatic unresectable pancreatic cancer at the time of diagnosis. Detection of pancreatic cancer at early stages remains a great challenge due to lack of accurate detection tests. Recommendations in existing clinical practice guidelines on early diagnosis of pancreatic cancer are inconsistent and based on limited evidence...
December 26, 2017: BMJ Open
https://www.readbyqxmd.com/read/29277802/value-of-diaphragmatic-surgery-during-interval-debulking-surgery
#11
Aurelie Pelissier, Oona Franke, Emile Darai, Gilles Houvenaeghel, Elisabeth Chereau, Roman Rouzier
BACKGROUND/AIM: The aim of this study was to assess the value of diaphragmatic surgery to achieve optimal debulking in patients with advanced ovarian cancer treated by neoadjuvant chemotherapy (NAC). PATIENTS AND METHODS: This is a retrospective review of the medical records of 182 patients. Diaphragmatic surgery was performed during interval debulking surgery (IDS) in 74 patients between January 2002 and December 2014. The patients were divided in 2 groups: with or without histological residual diaphragmatic disease...
January 2018: Anticancer Research
https://www.readbyqxmd.com/read/29276012/usefulness-of-ca125-and-their-kinetic-parameters-and-positron-emission-tomography-computed-tomography-pet-ct-with-fluorodeoxyglucose-18f-fdg-in-the-detection-of-recurrent-ovarian-cancer-levels
#12
Azahara Palomar Muñoz, José Manuel Cordero García, Prado Talavera Rubio, Ana M García Vicente, Beatriz González García, María Emiliana Bellón Guardia, Ángel Soriano Castrejón, Enrique Aranda Aguilar
BACKGROUND AND OBJECTIVE: To assess the usefulness of cancer antigen 125 (CA125) serum levels and kinetic values, velocity (CA125vel) and doubling time (CA125dt), as well as fluorodeoxyglucose ([18F]FDG) positron emission tomography/computed tomography (PET/CT), in the detection of ovarian cancer recurrence. To assess the optimal cut-off for CA125, CA125vel and CA125dt to detect relapse with [18F]FDG-PET/CT. MATERIAL AND METHODS: A retrospective analysis was performed of 59 [18F]FDG-PET/CT (48 patients) for suspected recurrence of ovarian cancer...
December 21, 2017: Medicina Clínica
https://www.readbyqxmd.com/read/29250663/immunohistochemical-diagnosis-of-krukenberg-tumors
#13
Melania Ioana Crăciun, Iacob Domşa
The diagnosis of Krukenberg tumors, as in other types of metastatic tumors of unknown primary origin, can often be a challenge for clinicians. In many cases, traditional diagnostic methods are insufficient, requiring immunohistochemistry analysis for identifying the origin of metastatic tumors. In our study, we examined a total of 34 female patients with Krukenberg tumors with different sites of the primary tumor: gastric (n=18), colorectal (n=6) or breast (n=7) and tumors with unknown origin (n=3). Cytokeratin (CK) 7 and CK20, carcinoembryonic antigen (CEA) and cancer antigen (CA) 125 were applied...
2017: Romanian Journal of Morphology and Embryology, Revue Roumaine de Morphologie et Embryologie
https://www.readbyqxmd.com/read/29244844/diagnostic-markers-for-the-detection-of-ovarian-cancer-in-brca1-mutation-carriers
#14
Daphne Gschwantler-Kaulich, Sigrid Weingartshofer, Christine Rappaport-Fürhauser, Robert Zeilinger, Dietmar Pils, Daniela Muhr, Elena I Braicu, Marie-Therese Kastner, Yen Y Tan, Lorenz Semmler, Jalid Sehouli, Christian F Singer
BACKGROUND: Screening for ovarian cancer (OC) in women at high risk consists of a combination of carbohydrate antigen 125 (CA125) and transvaginal ultrasound, despite their low sensitivity and specificity. This could be improved by the combination of several biomarkers, which has been shown in average risk patients but has not been investigated until now in female BRCA mutation carriers. METHODS: Using a multiplex, bead-based, immunoassay system, we analyzed the concentrations of leptin, prolactin, osteopontin, insulin-like growth factor II, macrophage inhibitory factor, CA125 and human epididymis antigen 4 in 26 healthy wild type women, 26 healthy BRCA1 mutation carriers, 28 wildtype OC patients and 26 OC patients with BRCA1 mutation...
2017: PloS One
https://www.readbyqxmd.com/read/29241375/peritoneal-dissemination-of-ovarian-cancer-role-of-muc16-mesothelin-interaction-and-implications-for-treatment
#15
Ricardo Coelho, Lara Marcos-Silva, Sara Ricardo, Filipa Ponte, Antonia Costa, Jose Manuel Lopes, Leonor David
Peritoneal dissemination is a particular form of malignant progression in ovarian cancer, preceding hematogenic or lymphatic dissemination. Thus, prevention of peritoneal implantation of cancer cells is envisioned to inhibit neoplastic dissemination and therefore prolong disease remission and patient's survival. Areas covered: An extended review on the role of MUC16 (CA125) and mesothelin (MSLN), expressed in a high percentage of ovarian carcinomas, indicate that this duet is relevant for the contact between cancer cells and mesothelial cells in homotypic (cancer cell-cancer cell) and heterotypic (cancer cell-mesothelial cell) interactions...
December 14, 2017: Expert Review of Anticancer Therapy
https://www.readbyqxmd.com/read/29238719/can-replacing-ca125-with-he4-in-risk-of-malignancy-indices-1-4-improve-diagnostic-performance-in-the-presurgical-assessment-of-adnexal-tumors
#16
Nabil Abdalla, Robert Piórkowski, Paweł Stanirowski, Krzysztof Cendrowski, Włodzimierz Sawicki
Aims: To assess whether replacing CA125 with HE4 in the classical formulas of risk of malignancy indices (RMIs) can improve diagnostic performance. Methods: For each of 312 patients with an adnexal mass, classical RMIs 1-4 were computed based on ultrasound score, menopausal status, and serum CA125 levels. Additionally, modified RMIs (mRMIs) 1-4 were recalculated by replacing CA125 with HE4. Results: Malignant pathology was diagnosed in 52 patients (16...
2017: BioMed Research International
https://www.readbyqxmd.com/read/29234710/polypoid-endometriosis-mimicking-invasive-cancer-in-an-obese-postmenopausal-tamoxifen-user
#17
William T Jaegle, Jason C Barnett, Bridget R Stralka, Nicole P Chappell
Background: Tamoxifen is a medication often used for the treatment and prevention of breast cancer. It is classically associated with several gynecological side effects to include a thickened endometrial stripe, increased uterine polyp formation, and an increased risk of uterine cancer. Rarely tamoxifen use has been associated with proliferation of endometriosis often severe enough to mimic a late-stage gynecologic malignancy. Case: A 62-year-old Gravida 0 postmenopausal female with a medical history of severe obesity, infertility, and preventative tamoxifen use presented for evaluation of gross hematuria...
November 2017: Gynecologic Oncology Reports
https://www.readbyqxmd.com/read/29231068/clinicopathological-and-prognostic-significance-of-platelet-count-in-patients-with-ovarian-cancer
#18
Q Zhou, F Huang, Z He, M-Z Zuo
AIM: Increasing evidence indicates that platelet count is a useful biomarker of long-term outcomes in patients with ovarian cancer. However, the prognostic value of platelet count in patients with ovarian cancer remains controversial. We therefore conducted a meta-analysis aimed to investigate the prognostic role of the platelet count in patients with ovarian cancer. METHOD: A comprehensive search was performed from the databases of PubMed, Embase and the Cochrane Library until June 20, 2017...
February 2018: Climacteric: the Journal of the International Menopause Society
https://www.readbyqxmd.com/read/29228624/platelet-microparticle-mediated-transfer-of-mir-939-to-epithelial-ovarian-cancer-cells-promotes-epithelial-to-mesenchymal-transition
#19
Meiling Tang, Lu Jiang, Yingying Lin, Xiaoli Wu, Kai Wang, Qizhi He, Xipeng Wang, Weiping Li
Epithelial ovarian cancer (EOC) patients frequently suffer from thrombocytosis, which leads to a poor prognosis. However, the mechanism underlying platelet regulation of biological behavior in EOC remains unclear. The associations between clinicopathological characteristics and thrombocytosis in 171 EOC patients were studied, preoperative thrombocytosis was significantly associated with the stage, metastasis scope, level of preoperative CA125 and overall survival. When SKOV3 cells were cocultured with platelet microparticles (PMPs), the expression of molecules associated with epithelial-mesenchymal transition (EMT) was increased...
November 14, 2017: Oncotarget
https://www.readbyqxmd.com/read/29226858/the-clinical-significance-of-the-combined-detection-of-serum-smac-he4-and-ca125-in-endometriosis-associated-ovarian-cancer
#20
Xin-Ran Xu, Xin Wang, Hong Zhang, Ming-Yan Liu, Qi Chen
OBJECTIVE: This study aims to investigate the clinical significance of serum Smac, HE4 and CA125 alone or combined for detecting endometriosis-associated ovarian cancer (EAOC). METHODS: The level of serum Smac, HE4 and CA125 in 40 healthy controls, 40 cases of benign endometriosis ovarian tumor, and 60 cases of EAOC were detected by ELISA and electrochemical immune method. RESULTS: Serum Smac expression level was significantly lower in the EAOC group than in the control group and benign ovarian tumor group (P< 0...
November 30, 2017: Cancer Biomarkers: Section A of Disease Markers
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