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https://www.readbyqxmd.com/read/28223716/preoperative-red-cell-distribution-width-and-neutrophil-to-lymphocyte-ratio-predict-survival-in-patients-with-epithelial-ovarian-cancer
#1
Zheng Li, Na Hong, Melissa Robertson, Chen Wang, Guoqian Jiang
Several parameters of preoperative complete blood count (CBC) and inflammation-associated blood cell markers derived from them have been reported to correlate with prognosis in patients with epithelial ovarian cancer (EOC), but their prognostic importance and optimal cutoffs are still needed be elucidated. Clinic/pathological parameters, 5-year follow-up data and preoperative CBC parameters were obtained retrospectively in 654 EOC patients underwent primary surgery at Mayo Clinic. Cutoffs for neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and monocyte-to-lymphocyte ratio (MLR) were optimized by receiver operating characteristic (ROC) curve...
February 22, 2017: Scientific Reports
https://www.readbyqxmd.com/read/28218038/postoperative-human-epididymis-protein-4-predicts-primary-therapy-outcome-in-advanced-epithelial-ovarian-cancer
#2
Tuulia Vallius, Johanna Hynninen, Annika Auranen, Jaakko Matomäki, Sinikka Oksa, Pia Roering, Seija Grènman
Primary chemotherapy treatment response monitoring in advanced epithelial ovarian cancer (EOC) is currently based on CT-imaging and serum CA125 values. Serum HE4 profile during first line chemotherapy has not been previously studied. We evaluated the HE4 profile during first line chemotherapy after primary (PDS) and interval debulking surgery (IDS). In total, 49 FIGO stage III/IV EOC patients were included in the study. 22 patients underwent PDS and 27 patients neoadjuvant chemotherapy (NACT) followed by IDS...
February 2017: Tumour Biology: the Journal of the International Society for Oncodevelopmental Biology and Medicine
https://www.readbyqxmd.com/read/28214872/higher-numbers-of-t-bet-tumor-infiltrating-lymphocytes-associate-with-better-survival-in-human-epithelial-ovarian-cancer
#3
Yun Xu, Lujun Chen, Bin Xu, Yuqi Xiong, Min Yang, Xiaohui Rui, Liangrong Shi, Changping Wu, Jingting Jiang, Binfeng Lu
BACKGROUND/AIMS: T-bet, a member of the T-box family of transcription factors, is a key marker of type I immune response within the tumor microenvironment, and has been previously reported by us to serve as an important prognostic indicator for human gastric cancer patients and a potential biomarker for immunotherapy. In the present study, we aimed to assess the clinical significance and prognostic value of T-bet+ tumor-infiltrating lymphocytes in human epithelial ovarian cancer. METHODS: The immunohistochemistry was used to analyze the infiltration density of T-bet+ lymphoid cells in human epithelial ovarian cancer tissues, and the flow cytometry analysis was used to further analyze the presence of T-bet+ tumor-infiltrating lymphocytes subgroups in cancer tissues...
January 30, 2017: Cellular Physiology and Biochemistry
https://www.readbyqxmd.com/read/28213228/smartphone-based-immunosensor-for-ca125-detection
#4
Oana Hosu, Andrea Ravalli, Giuseppe Mattia Lo Piccolo, Cecilia Cristea, Robert Sandulescu, Giovanna Marrazza
In this work, we report the design, the development and the characterization of the analytical performances of a colorimetric smartphone-based immunosensor for the detection of cancer antigen 125 (CA125). The immunosensor was based on a sandwich strategy in which the primary antibody was immobilized by spotting onto the 3D nitrocellulose membrane. The immunospots were subsequently incubated with CA125 solutions, followed by the affinity reaction with a secondary antibody labeled with gold nanoparticles (AuNPs)...
May 1, 2017: Talanta
https://www.readbyqxmd.com/read/28209488/postoperative-maintenance-levonorgestrel-releasing-intrauterine-system-and-endometrioma-recurrence-a-randomized-controlled-study
#5
Yi-Jen Chen, Teh-Fu Hsu, Ben-Shian Huang, Hsiao-Wen Tsai, Yen-Hou Chang, Peng-Hui Wang
BACKGROUND: According to three randomized trials, levonorgestrel-releasing intrauterine system significantly reduced recurrent endometriosis- related pelvic pain at postoperative year 1. Only a few studies have evaluated the long-term effectiveness of the devicefor preventing endometrioma recurrence, and the effects of a levonorgestrel-releasing intrauterine system as a maintenance therapy remain unclear. OBJECTIVES: To evaluate whether a maintenance levonorgestrel-releasing intrauterine system is effective for preventing postoperative endometrioma recurrence...
February 13, 2017: American Journal of Obstetrics and Gynecology
https://www.readbyqxmd.com/read/28194593/synchronous-endometrial-and-ovarian-carcinomas-predictors-of-risk-and-associations-with-survival-and-tumor-expression-profiles
#6
Linda E Kelemen, Peter F Rambau, Jennifer M Koziak, Helen Steed, Martin Köbel
PURPOSE: Synchronous endometrial and ovarian tumors (SEOs) are diagnosed in 10% of ovarian cancer patients. We examined predictors of SEOs, evaluated associations of SEOs with survival and characterized ovarian tumor profiles using immunohistochemistry. METHODS: We included patients with endometrioid (n = 180) and clear cell (n = 165) ovarian carcinoma identified from the Alberta Cancer Registry between 1979 and 2010 for whom we abstracted medical records and constructed tumor tissue microarrays (TMAs)...
February 13, 2017: Cancer Causes & Control: CCC
https://www.readbyqxmd.com/read/28187738/naturally-occurring-anti-glycan-antibodies-binding-to-globo-h-expressing-cells-identify-ovarian-cancer-patients
#7
Tatiana Pochechueva, Shahidul Alam, Andreas Schötzau, Alexander Chinarev, Nicolai V Bovin, Neville F Hacker, Francis Jacob, Viola Heinzelmann-Schwarz
BACKGROUND: Glycosphingolipids are important compounds of the plasma membrane of mammalian cells and a number of them have been associated with malignant transformation and progression, reinforcing tumour aggressiveness and metastasis. Here we investigated the levels of naturally occurring anti-glycan antibodies to Globo H in blood plasma obtained from high-grade serous ovarian cancer patients (SOC) and women without gynaecological malignancies (control) using suspension glycan array technology employing chemically synthesized glycans as antibody targets...
February 10, 2017: Journal of Ovarian Research
https://www.readbyqxmd.com/read/28174387/-a-case-of-heterochronic-ovarian-metastasis-from-sigmoid-colon-cancer-after-sigmoidectomy-treated-with-capeox-that-included-bevacizumab
#8
Reiko Ono, Norihito Ise, Hiroshi Yoshioka, Wataru Iwasaki, Kimihiko Sato, Makoto Niwa
The patient was a 41-year-old woman. When she was 39 years old, she had undergone laparoscopic high anterior resection for sigmoid colon cancer without adjuvant chemotherapy. Histologically, the surgical specimen was type 2, tub2, pT4a (SE), pN0, int, INF b, ly1, v1, and pStage II. Nine months after the operation, she suffered from abdominal fullness. Laborato- rydata showed elevation of tumor markers: the CEA level was 6.48 ng/mL, the CA19-9 level was 89.70 U/mL, and the CA125 level was 662 U/mL. Computed tomographyrevealed bilateral ovarian tumors and lung and peritoneal nodules with massive ascites...
January 2017: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28164624/elevated-preoperative-platelet-to-lymphocyte-ratio-indicates-poor-survival-in-patients-with-resected-high-grade-serous-ovarian-carcinoma
#9
Dan Hu, Youdong Lin, Fangfang Liu, Li Zeng, Xiaojuan Ouyang, Kai Wang, Xiongwei Zheng, Qiaojia Huang
BACKGROUND: Platelet to lymphocyte ratio (PLR) is widely used as an inflammation-related cancer biomarker. However, since its prognostic importance in resected high-grade serous ovarian carcinoma (HGSC) is still unknown, we investigated the association between PLR and the prognosis in resected HGSC in this study. METHODS: Details of 103 patients with HGSC who underwent ovarian resection were collected in this retrospective study. Preoperative PLR was calculated based on platelet and lymphocyte count values...
August 1, 2016: Clinical Laboratory
https://www.readbyqxmd.com/read/28162178/-a-clinical-study-on-the-pathogenesis-of-lung-cancer-related-cerebral-infarction
#10
X R Xie, C Qin, L Chen, D B Cheng, J Y Huang, X X Wei, L X Yu, Z J Liang
Objective: To explore the risk factors for lung cancer-related cerebral infarction. Methods: The hospitalized active lung cancer patients on anti-cancer therapy with no traditional stroke risk factors, who experienced an acute cerebral infarct in the First Affiliated Hospital of Guangxi Medical University from January 2005 to December 2015, were consecutively collected as the LCRS (lung cancer-related stroke) group. The active lung cancer patients without cerebral infarction hospitalized at the same peroid matched with the LCRS group for age and gender were collected as the LC (lung cancer) group...
February 1, 2017: Zhonghua Nei Ke za Zhi [Chinese Journal of Internal Medicine]
https://www.readbyqxmd.com/read/28157643/ratios-of-biochemical-markers-in-peritoneal-fluid-to-those-in-venous-blood-for-the-diagnosis-of-ruptured-tubal-pregnancy-a-prospective-study
#11
Xiao-Lu Zhu, Zhuo-Wei Xue, Yan-Li Xu, Juan Wang, Zhi-Hong Ai, Yin-Cheng Teng
OBJECTIVES: Ectopic pregnancies are among the leading causes of maternal morbidity and mortality in both developed and emerging nations, but tests for early, accurate, and convenient detection are lacking. STUDY DESIGN: Between January 2013 and February 2015, 504 women with tubal pregnancy were prospectively recruited, and their clinical characteristics were recorded. Samples of peritoneal fluid were collected by culdocentesis, and venous blood was drawn from the antecubital vein...
January 18, 2017: European Journal of Obstetrics, Gynecology, and Reproductive Biology
https://www.readbyqxmd.com/read/28143870/early-detection-of-ovarian-cancer-using-the-risk-of-ovarian-cancer-algorithm-with-frequent-ca125-testing-in-women-at-increased-familial-risk-combined-results-from-two-screening-trials
#12
Steven J Skates, Mark H Greene, Saundra S Buys, Phuong L Mai, Powel H Brown, Marion Piedmonte, Gustavo C Rodriguez, John O Schorge, Mark Sherman, Mary B Daly, Thomas J Rutherford, Wendy R Brewster, David M O'Malley, Edward E Partridge, John Boggess, Charles W Drescher, Claudine Isaacs, Andrew Berchuck, Susan M Domchek, Susan A Davidson, Robert P Edwards, Steven A Elg, Katie Wakeley, Kelly-Anne Phillips, Deborah K Armstrong, Ira R Horowitz, Carol J Fabian, Joan Walker, Patrick M Sluss, William R Welch, Lori Minasian, Nora Horick, Carol H Kasten, Susan Nayfield, David S Alberts, Dianne M Finkelstein, Karen Lu
PURPOSE: Women at familial/genetic ovarian cancer risk often undergo screening despite unproven efficacy. Research suggests each woman has her own CA125 baseline; significant increases above this level may identify cancers earlier than standard 6-12 monthly CA125>35U/mL. EXPERIMENTAL DESIGN: Data from prospective Cancer Genetics Network and Gynecologic Oncology Group trials, which screened 3,692 women (13,080 woman-screening years) with a strong breast/ovarian cancer family history or BRCA1/2 mutations, were combined to assess a novel screening strategy...
January 31, 2017: Clinical Cancer Research: An Official Journal of the American Association for Cancer Research
https://www.readbyqxmd.com/read/28133286/-serous-carcinoma-of-the-peritoneum-with-metastases-to-the-breast-and-axillary-lymph-nodes
#13
Aiko Ueda, Daigo Yamamoto, Yu Tsubota, Noriko Sueoka, Katsuhiro Yoshikawa, Masanori Kon
: Metastasis of peritoneal serous carcinoma to the breast and axillary lymph nodes is rare. We present a case of serous carcinoma of the peritoneum with metastases to the breast and axillary lymph nodes. A 72-year-old woman was diagnosed with Stage III peritoneal serous carcinoma in November 2009; she was treated with 6 courses of paclitaxel and carboplatin. In December 2015, she had a palpable mass(2×2 cm)and enlarged axillary lymph nodes. Mammography did not reveal any mass(C1)and ultrasonographic examination demonstrated a partially ill-defined hypoechoic mass with a diameter of 8...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133247/-successful-multidisciplinary-treatment-of-metastatic-ovarian-cancer-after-perforative-peritonitis-of-the-rectum-due-to-disseminated-ovarian-cancer
#14
Taiping Huang, Makoto Nakamuro, Hiroshi Nakano, Yuhei Okubo, Yoshiaki Kondo, Kazuo Ishikawa, Hiroshi Furukawa, Ichiro Amakawa, Koichi Matsumoto, Kozo Kadowaki, Yoshio Ohta
A72 -year-old woman who complained of abdominal pain and distention visited the emergency clinic of our hospital in April 2014. Computed tomography(CT)showed an omental mass and a pelvic mass with massive ascites. The fluid was removed by abdominal aspiration, and the patient showed perforative peritonitis next day. An emergency operation was performed. The surgical operation showed that the rectum was perforated due to stenosis covered by the ovarian cancer metastases. Aleft colectomy combined with a transverse colostomy was performed...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28133197/-a-case-of-early-onset-rapidly-progressive-cerebral-infarction-with-trousseau-s-syndrome-in-a-patient-with-pancreatic-cancer-undergoing-surgery
#15
Norikazu Yogi, Hiroyuki Nojima, Hiroaki Shimizu, Masayuki Ohtsuka, Atsushi Kato, Hideyuki Yoshitomi, Katsunori Furukawa, Tsukasa Takayashiki, Shigetsugu Takano, Satoshi Kuboki, Daisuke Suzuki, Nozomu Sakai, Shingo Kagawa, Masaru Miyazaki
Trousseau's syndrome refers to cerebral infarction associated with hypercoagulability caused by cancer. Here, we report a case of Trousseau's syndrome in a patient with pancreatic cancer undergoing surgery. A 71-year-old woman was diagnosed with pancreatic head cancer with portal vein invasion; she underwent pancreaticoduodenectomy combined with portal vein resection. Pathological examination showed poorly differentiated adenocarcinoma with para-aortic lymph nodal metastasis. Although the patient had an uneventful postoperative course, she suddenly developed right hemiplegia and dysarthria 6 weeks after surgery, resulting in multiple cerebral infarctions scattered over both hemispheres...
November 2016: Gan to Kagaku Ryoho. Cancer & Chemotherapy
https://www.readbyqxmd.com/read/28129244/aberrant-microrna-expression-in-patients-with-endometrial-cancer
#16
Martina Montagnana, Marco Benati, Elisa Danese, Silvia Giudici, Melissa Perfranceschi, Orazio Ruzzenenete, Gian Luca Salvagno, Antonella Bassi, Matteo Gelati, Elisa Paviati, Gian Cesare Guidi, Massimo Franchi, Giuseppe Lippi
OBJECTIVE: Current evidence suggests that no single serum biomarker displays satisfactory diagnostic performance in patients with endometrial carcinoma (EC), the most frequent gynecological cancer in developed countries. However, aberrant tissue microRNA (miRNA) expression has been recently described in EC. Therefore, this study aimed to investigate the differential expression of 4 serum miRNAs and their association with CA125 (cancer antigen 125) and HE4 (human epididymis protein 4) in EC patients and in a control population...
March 2017: International Journal of Gynecological Cancer
https://www.readbyqxmd.com/read/28128425/analysis-of-specific-serum-markers-of-colon-carcinoma-using-a-bhattacharyya-based-support-vector-machine
#17
W Y Yang, G Shi, L P Wu, S T Wei, Y N Huang, L X Tan, R Z Yang, C X Yan, E T Guo, H Y Wang, J Z Tong, Y Dong, D Z Han
We aimed to evaluate the specificity of 12 tumor markers related to colon carcinoma and identify the most sensitive index. Bhattacharyya distance was used to evaluate the index. Then, different index combinations were used to establish a support vector machine (SVM) diagnosis model of malignant colon carcinoma. The accuracy of the model was checked. High accuracy was assumed to indicate the high specificity of the index. The Bhattacharyya distances of carcinoembryonic antigen, neuron-specific enolase, alpha-feto protein, and CA724 were the largest, and those of CYFRA21-І, CA125, and UGT1A83 were the second largest...
January 23, 2017: Genetics and Molecular Research: GMR
https://www.readbyqxmd.com/read/28127669/neuron-specific-enolase-and-response-to-initial-therapy-are-important-prognostic-factors-in-patients-with-small-cell-lung-cancer
#18
M Zhou, Z Wang, Y Yao, H Zhou, M Liu, J Sun
PURPOSE: The prognostic factors for the survival of small cell lung cancer (SCLC) patients are still widely debated. The aim of this study was to identify the clinical features and prognostic factors in SCLC patients. METHODS: A retrospective study was conducted on SCLC patients who were treated in our hospital between July 2010 and July 2015. Comparison of overall survival (OS) was performed using the Kaplan-Meier method. Prognostic factors for OS were identified by multivariate Cox regression models...
January 26, 2017: Clinical & Translational Oncology
https://www.readbyqxmd.com/read/28122418/improving-clinical-management-of-women-with-borderline-tumours-a-recurrence-risk-scoring-system-from-a-french-multicenter-study
#19
Lobna Ouldamer, Sofiane Bendifallah, Myriam Nikpayam, Gilles Body, Xavier Fritel, Catherine Uzan, Philippe Morice, Emile Daraï, Marcos Ballester
OBJECTIVE: To develop a risk scoring system (RSS) for predicting recurrence in women with borderline ovarian tumours (BOT). DESIGN: Cohort study of women with BOT SETTING: French multicenter tertiary care centers. POPULATION: 360 women with BOT who received primary surgical treatment between January 2000 and December 2013. METHODS: Clinical and pathological factors impacting recurrence in women with BOT. MAIN OUTCOME MEASURES: Development of a model for the prediction of recurrence in women with BOT...
January 25, 2017: BJOG: An International Journal of Obstetrics and Gynaecology
https://www.readbyqxmd.com/read/28108627/oncogenic-kras-targets-muc16-ca125-in-pancreatic-ductal-adenocarcinoma
#20
Chen Liang, Yi Qin, Bo Zhang, Shunrong Ji, Si Shi, Wenyan Xu, Jiang Liu, Jinfeng Xiang, Dingkong Liang, Qiangsheng Hu, Quanxing Ni, Jin Xu, Xianjun Yu
: Pancreatic ductal adenocarcinoma (PDAC) is a devastating disease with the 5-year survival rate less than 6%. Previous results indicated that serum levels of CA125 (encoded by MUC16) could be used to predict which groups of pancreatic cancer patients may benefit from surgery. However, the underlying mechanism remains elusive. Herein, using the Cancer Genome Atlas and clinicopathologic data obtained from our center, we demonstrate that high CA125 serum levels and expression levels of MUC16 are predictive of poor prognosis...
January 20, 2017: Molecular Cancer Research: MCR
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