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https://www.readbyqxmd.com/read/28339090/inhibition-of-farnesyl-pyrophosphate-synthase-attenuates-high-glucose%C3%A2-induced-vascular-smooth-muscle-cells-proliferation
#1
Guo-Ping Chen, Xiao-Qin Zhang, Tao Wu, Jie Han, Dan Ye
The proliferation of vascular smooth muscle cells (VSMCs) is one of the main features of atherosclerosis accelerated by hyperglycemia. Our previous studies found that farnesyl pyrophosphate synthase (FPPS, EC 2.5.1.10), an essential enzyme in the mevalonate pathway, was upregulated in aorta media from diabetic mice along with the process of atherosclerosis. However, the exact role of FPPS in high glucose‑induced proliferation of VSMCs is largely unclear. In our study, we found that alendronate (an FPPS inhibitor) attenuated diabetic accelerated atherosclerosis in vivo and suppressed high glucose‑induced VSMCs proliferation in vitro...
March 23, 2017: Molecular Medicine Reports
https://www.readbyqxmd.com/read/28338590/small-changes-big-effects-the-hemodynamics-of-partial-and-complete-aortic-occlusion-to-inform-next-generation-resuscitation-techniques-and-technologies
#2
M Austin Johnson, Anders J Davidson, Rachel M Russo, Sarah-Ashley E Ferencz, Oren Gotlib, Todd E Rasmussen, Lucas P Neff, Timothy K Williams
BACKGROUND: The transition from complete aortic occlusion during Resuscitative Endovascular Balloon Occlusion of the Aorta (REBOA) can be associated with hemodynamic instability. Technique refinements and new technologies have been proposed to minimize this effect. In order to inform new techniques and technology, we examined the relationship between blood pressure and aortic flow during the restoration of systemic circulation following aortic occlusion at progressive levels of hemorrhage...
March 23, 2017: Journal of Trauma and Acute Care Surgery
https://www.readbyqxmd.com/read/28337891/screening-and-comparison-of-polychromatic-and-monochromatic-image-reconstruction-of-abdominal-arterial-energy-spectrum-ct
#3
X P Wang, B Wang, P Hou, R Li, J B Gao
We screened the suitable image reconstruction to observe the abdominal artery and compare the quality between the polychromatic and the monochromatic reconstruction images of the abdominal artery spectrum CT. Eighty patients underwent Gemstone CT energy spectrum imaging to obtain an abdominal artery polychromatic image (140 kVp) and a monochromatic image from 40 ~ 140 keV. The CT value of region of interest (ROI) was measured on the polychromatic image and the single energy image. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) of the abdominal aorta and hepatic artery were determined...
January 2017: Journal of Biological Regulators and Homeostatic Agents
https://www.readbyqxmd.com/read/28337519/the-draped-aorta-sign-of-impending-aortic-aneurysm-rupture
#4
REVIEW
Eduardo Kaiser Ururahy Nunes Fonseca, Adham do Amaral E Castro, Amanda de Vasconcelos Chambi Tames, Eduardo Matarolo Jayme, Omir Antunes Paiva, Luis Ricardo Sokolowski
No abstract text is available yet for this article.
March 24, 2017: Abdominal Radiology
https://www.readbyqxmd.com/read/28337456/comparison-of-the-protective-effects-of-individual-components-of-particulated-trans-sialidase-ptcts-ptc-and-ts-against-high-cholesterol-diet-induced-atherosclerosis-in-rabbits
#5
Shérrira M Garavelo, Maria de Lourdes Higuchi, Jaqueline J Pereira, Marcia M Reis, Joyce T Kawakami, Renata N Ikegami, Suely A P Palomino, Nilsa S Y Wadt, Abdelali Agouni
Previous studies showed the presence of Mycoplasma pneumoniae (M. pneumoniae) and membrane-shed microparticles (MPs) in vulnerable atherosclerotic plaques. H&S Science and Biotechnology developed PTCTS, composed by natural particles from medicinal plants (PTC) combined with trans-Sialidase (TS), to combat MPs and Mycoplasma pneumoniae. Our aim was to determine the effects of the different components of PTCTS in a rabbit model of atherosclerosis. Rabbits were fed with high cholesterol diet for 12 weeks and treated during the last 6 weeks with either vehicle, PTC, TS, or PTCTS...
2017: BioMed Research International
https://www.readbyqxmd.com/read/28337251/pentaerythritol-tetranitrate-in-vivo-treatment-improves-oxidative-stress-and-vascular-dysfunction-by-suppression-of-endothelin-1-signaling-in-monocrotaline-induced-pulmonary-hypertension
#6
Sebastian Steven, Matthias Oelze, Moritz Brandt, Elisabeth Ullmann, Swenja Kröller-Schön, Tjebo Heeren, Lan P Tran, Steffen Daub, Mobin Dib, Dirk Stalleicken, Philip Wenzel, Thomas Münzel, Andreas Daiber
Objective. Oxidative stress and endothelial dysfunction contribute to pulmonary arterial hypertension (PAH). The role of the nitrovasodilator pentaerythritol tetranitrate (PETN) on endothelial function and oxidative stress in PAH has not yet been defined. Methods and Results. PAH was induced by monocrotaline (MCT, i.v.) in Wistar rats. Low (30 mg/kg; MCT30), middle (40 mg/kg; MCT40), or high (60 mg/kg; MCT60) dose of MCT for 14, 28, and 42 d was used. MCT induced endothelial dysfunction, pulmonary vascular wall thickening, and fibrosis, as well as protein tyrosine nitration...
2017: Oxidative Medicine and Cellular Longevity
https://www.readbyqxmd.com/read/28336529/toe-imaging-of-a-large-aortic-mass-an-unusual-cause-of-systemic-embolization-in-a-septic-patient
#7
Sarah R Blake, Jamal Khan, Adrian Chenzbraun
A 72-year-old woman presented with sepsis and lower limb ischaemia. Transoesophageal echocardiography (TOE) for suspected endocarditis revealed no cardiac pathology or source of emboli but a large thrombus-like mass was noted in a normal size descending aorta (Fig. 1A, Video 1). Repeat TOE after two weeks of anticoagulation showed two new masses and no change in the size of the original one (Fig. 1B). The patient died following bilateral leg amputation. There was no PM to provide pathology confirmation but the most likely diagnosis was of a thrombus, possibly infected...
March 23, 2017: Echo Research and Practice
https://www.readbyqxmd.com/read/28335161/monocentric-comparative-study-of-conventional-surgery-and-endovascular-treatment-with-fenestrated-stentgrafts-to-treat-juxtarenal-and-pararenal-aneurysms-of-the-abdominal-aorta
#8
Raphael Soler, Michel A Bartoli, Gaëtan Simonet, Marie C Bordes, Marine Gaudry, Gabrielle Sarlon-Bartoli, Pierre-Edouard Magnan
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335160/short-and-mid-term-evaluation-of-the-risk-of-persistent-type-ii-endoleak-after-endovascular-treatment-of-an-uncomplicated-aneurysm-of-the-abdominal-aorta-with-the-nellix-%C3%A2-stentgraft-a-french-multicentric-study
#9
Heloise Samba, Alsac Jean-Marc, Robert Martinez, Adrien Kaladji, Pierre Julia, Alain Cardon, Patrick Feugier
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335154/comparative-analysis-of-the-results-of-the-conventional-surgical-treatment-of-the-juxtarenal-and-suprarenal-abdominal-aorta
#10
Xavier Chaufour, Jean Segal, Benoit Lebas, Malcolm Le Gall, Julien Galley
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335146/comparison-of-open-and-endovascular-surgery-for-the-treatment-of-the-infections-of-the-thoracic-aorta
#11
Yamume Tshomba, Marco Leopardi, Andrea Kahlberg, Daniele Mascia, Domenico Baccellieri, Germano Melissano, Roberto Chiesa
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335143/aortic-non-covered-stents-to-treat-complicated-acute-type-b-aortic-dissections-lessons-learned-from-seven-years-from-s-o-s-aorta
#12
Jean-Marc Alsac, Salma El Batti, Auréline Boitet, Marwan Abou Rjeili, Pierre Julia
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335137/tevar-in-emergency-for-the-treatment-of-the-ruptured-aneurysms-of-the-descending-thoracic-aorta
#13
Harry Etienne, Marek Majewski, Frédéric Cochennec, Lauriane Segaux, Jean-Pierre Becquemin
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335136/retrospective-analysis-of-type-a-aortic-dissections-after-debranching-of-the-supra-aortic-trunks-and-stentgraft-of-the-aortic-arch-the-side-clamping-of-the-ascending-aorta-is-responsible
#14
Dorian Verscheure, Julien Gaudric, Quentin Pellenc, Arnaud Roussel, Laurent Chiche, Fabien Koskas
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335133/aneurysms-of-the-thoraco-abdominal-aorta-a-comparison-with-propensity-score-between-endovascular-repair-and-open-surgery
#15
Yamume Tshomba, Marco Leopardi, Ciro Ferrer, Piergiorgio Cao, Paola De Rango, Fabio Verzini, Germano Melissano, Carlo Coscarella, Roberto Chiesa
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28335132/anatomical-evolution-of-the-descending-thoracic-aorta-after-endovascular-treatment-of-a-degenerative-aneurysm
#16
Virgile Omnes, Philippe Amabile, Laurence Bal, Mariangela de Masi, Marine Gaudry, Baptiste David, David Bensoussan, Jean-Michel Bartoli, Michel Bartoli, Pierre-Édouard Magnan, Philippe Piquet
No abstract text is available yet for this article.
January 2017: Annals of Vascular Surgery
https://www.readbyqxmd.com/read/28334545/-conservative-treatment-of-late-aortic-graft-infection
#17
Peter Baľa, Kamil Zeman, Renata Kološová, Ivo Pavlas, Dušan Kučera
Aortic graft infection is one of the most serious complications of aortovascular surgery. Diagnosis is based on clini-cal and radiologic findings. The emphasis is put on early diagnosis and its impact on prognosis of patients. The management should be individualized. The gold standard is surgical treatment with complete excision of the infected foreign material with debridement of the surrounding tissue and repair of vascular continuity by extra-anatomic bypass or in situ bypass with autologous femoral vein or cryopreserved arterial allografts...
2017: Vnitr̆ní Lékar̆ství
https://www.readbyqxmd.com/read/28334369/isotropic-failure-criteria-are-not-appropriate-for-anisotropic-fibrous-biological-tissues
#18
Christopher E Korenczuk, Lauren E Votava, Rohit Y Dhume, Shannen B Kizilski, George E Brown, Rahul Narain, Victor H Barocas
The von Mises (VM) stress is a common stress measure for finite-element models of tissue mechanics. The VM failure criterion, however, is inherently isotropic, and therefore may yield incorrect results for anisotropic tissues, and the relevance of the VM stress to anisotropic materials is not clear. We explored the application of a well-studied anisotropic failure criterion, the Tsai-Hill (TH) theory, to the mechanically anisotropic porcine aorta. Uniaxial dogbones were cut at different angles and stretched to failure...
March 23, 2017: Journal of Biomechanical Engineering
https://www.readbyqxmd.com/read/28332448/mechanical-behavior-of-porcine-thoracic-aorta-in-physiological-and-supra-physiological-intraluminal-pressures
#19
Mobin Rastgar Agah, Kaveh Laksari, Soroush Assari, Kurosh Darvish
Understanding the mechanical behavior of aorta under supra-physiological loadings is an important aspect of modeling tissue behavior in various applications that involve large deformations. Utilizing inflation-extension experiments, the mechanical behavior of porcine descending thoracic aortic segments under physiological and supra-physiological intraluminal pressures was investigated. The pressure was changed in the range of 0-70 kPa and the deformation of the segment was determined in three dimensions using a custom-made motion capture system...
April 2017: Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine
https://www.readbyqxmd.com/read/28332442/ultrasound-imaging-in-the-diagnosis-of-large-vessel-vasculitis
#20
Michael Czihal, Christian Lottspeich, Ulrich Hoffmann
Nowadays noninvasive vascular imaging has an important role in the diagnostic work-up of the large vessel vasculitides (LVV), most importantly giant cell arteritis (GCA) and Takayasu arteritis. Among the imaging modalities available, ultrasound (US) has several important advantages, including low costs, rapid and repetitive availability without exposure to radiation, and high spatial resolution for assessment of large and medium-sized arteries. Therefore, US can be regarded the first line imaging method in suspected LVV...
March 23, 2017: VASA. Zeitschrift Für Gefässkrankheiten
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