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Atrial fibrillation AND inflammation

Shi-Mao Zhong, Yu-Hua Qin, Zuo-Cha Li, Ye-Sheng Wei
OBJECTIVE: To investigate the relationship between atrial fibrillation (AF) and serum soluble CD163. METHODS: A total of 336 patients with heart valve disease were included in this study, including 167 with AF and 169 with sinus rhythm. The clinical data were compared between the two grops, and Logistic regression analysis was used to identify the risk factors associated with AF. RESULTS: The levels of total cholesterol (TC), high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), tumor necrosis factor (TNF), interleukin-6 (IL - 6), high-sensitivity C-reactive protein (hs-CRP) and left atrial diameter (LAD) all differed significantly between the two groups (P<0...
October 20, 2016: Nan Fang Yi Ke da Xue Xue Bao, Journal of Southern Medical University
Dong-Hyun Choi, Seong-Ho Kang, Heesang Song
Platelets are essential for progression of atherosclerotic lesions, plaque destabilization, and thrombosis. They secrete and express many substances that are crucial mediators of coagulation, inflammation, and atherosclerosis. Mean platelet volume (MPV) is a precise measure of platelet size, and is routinely reported during complete blood count analysis. Emerging evidence supports the use of MPV as a biomarker predicting the risk of ischemic stroke in patients with atrial fibrillation, and as a guide for prescription of anticoagulation and rhythm-control therapy...
October 24, 2016: Korean Journal of Internal Medicine
Farah Z Dawood, Suzanne Judd, Virginia J Howard, Nita A Limdi, James F Meschia, Mary Cushman, George Howard, David M Herrington, Elsayed Z Soliman
The relation between inflammation and prothrombotic state in atrial fibrillation (AF) is well recognized. This suggests a potential role for high-sensitivity C-reactive protein (hs-CRP), a marker of systemic inflammation, in improving prediction of stroke in participants with AF. Cox proportional hazard analysis was used to examine the risk of stroke in 25,841 participants (40% black and 55% women) with and without AF who were enrolled in the Reasons for Geographic and Racial Differences in Stroke study from 2003 to 2007...
September 14, 2016: American Journal of Cardiology
Anna M May, David R Van Wagoner, Reena Mehra
A surge of data has reproducibly identified strong associations of obstructive sleep apnea (OSA) with cardiac arrhythmias. As an extension of epidemiologic and clinic-based findings, experimental investigations have made strides in advancing our understanding of the putative OSA and cardiac arrhythmogenesis mechanistic underpinnings. While most studies have focused on the links between OSA and atrial fibrillation (AF), relationships with ventricular arrhythmias have also been characterized. Key findings implicate OSA-related autonomic nervous system fluctuations typified by enhanced parasympathetic activation during and sympathetic surges subsequent to respiratory events which contribute to augmented arrhythmic propensity...
September 29, 2016: Chest
Adrian D Elliott, Rajiv Mahajan, Dennis H Lau, Prashanthan Sanders
Exercise training has considerable health benefits. However, recent research has demonstrated a greater risk of atrial arrhythmias in endurance athletes. The mechanisms promoting atrial fibrillation in athletes are unclear but there seems to be a central role for atrial remodeling, accompanied by autonomic alterations and inflammation. Animal studies have provided unique insights, yet prospective human data are lacking. Treatment options seem to yield similar efficacy to that seen in a nonathletic population and may be justified as an early rhythm control strategy...
November 2016: Cardiology Clinics
Inger Njølstad, Ellisiv B Mathiesen, Henrik Schirmer, Dag Steinar Thelle
The rapid increase of coronary heart disease mortality in Northern Norway during 1951-1970 was why the newly established University of Tromsø decided to start a study to identify major operating cardiovascular risk factors. The first Tromsø survey in 1974 suggested that the relatively high cardiovascular mortality was associated with elevated cholesterol levels and high prevalence of smoking, while high-density-lipoprotein-cholesterol (HDL-C) was identified as a preventive factor. After 1974, six more surveys including both genders (aged 20 to 89 years) were undertaken...
September 21, 2016: Scandinavian Cardiovascular Journal: SCJ
Graeme J Hankey
In the past decade, the definition of stroke has been revised and major advances have been made for its treatment and prevention. For acute ischaemic stroke, the addition of endovascular thrombectomy of proximal large artery occlusion to intravenous alteplase increases functional independence for a further fifth of patients. The benefits of aspirin in preventing early recurrent ischaemic stroke are greater than previously recognised. Other strategies to prevent recurrent stroke now include direct oral anticoagulants as an alternative to warfarin for atrial fibrillation, and carotid stenting as an alternative to endarterectomy for symptomatic carotid stenosis...
September 13, 2016: Lancet
Yu-Jui Kuo, Tzu-Hsien Tsai, Hui-Ping Chang, Sarah Chua, Sheng-Ying Chung, Cheng-Hsu Yang, Cheng-Jei Lin, Chiung-Jen Wu, Chi-Ling Hang
Many studies have found that systemic inflammation plays an important role in the pathogenesis of atrial fibrillation (AF). Gout is a chronic systemic inflammatory disorder, but little evidence exists regarding whether the risk of AF is increased in patients with gout. The National Health Insurance Research Database in Taiwan was used in this study, and gout was defined as the occurrence of at least one episode of an acute gout attack requiring medical treatment. A total of 63264 gout and 63264 age- and gender-matched patients were included as the study population...
2016: Scientific Reports
Li-Hui Zheng, Wei Sun, Yan Yao, Bing-Bo Hou, Yu Qiao, Shu Zhang
BACKGROUND: Atrial fibrillation (AF) is associated with inflammation and endothelial dysfunction. However, the association between inflammation (as indexed by high-sensitivity C-reactive protein, hs-CRP) and endothelial function [as indexed by big endothelin-1 (ET-1)] in AF patients remains unclear. METHODS: We enrolled 128 patients with lone AF, among which 83 had paroxysmal AF, and 45 had persistent AF. Eighty-two age- and gender-matched controls of paroxysmal supraventricular tachycardia without AF history were evaluated...
July 2016: Journal of Geriatric Cardiology: JGC
Sara Roversi, Leonardo M Fabbri, Don D Sin, Nathaniel M Hawkins, Alvar Agusti
Chronic obstructive pulmonary disease (COPD) is a global health issue with high social and economic costs. Concomitant chronic cardiac disorders are frequent in patients with COPD, likely due to shared risk factors (e.g. ageing, cigarette smoke, inactivity, persistent low-grade pulmonary and systemic inflammation) and add to the overall morbidity and mortality of COPD patients. The prevalence and incidence of cardiac comorbidities are higher in COPD patients than in matched control subjects, although estimates of prevalence vary widely...
September 2, 2016: American Journal of Respiratory and Critical Care Medicine
Jason D Roberts, Jingkun Yang, Rachel A Gladstone, James Longoria, Isaac R Whitman, Thomas A Dewland, Caroline Miller, Anatalia Robles, Annie Poon, Beverly Seiler, William A Laframboise, Jeffrey E Olgin, Pui-Yan Kwok, Gregory M Marcus
INTRODUCTION: Genome wide association studies have identified several single nucleotide polymorphisms (SNPs) associated with atrial fibrillation (AF), but the mechanisms underlying these relationships have not yet been elucidated. Inflammation and fibrosis have been posited as important mechanisms responsible for AF. We sought to investigate the impact of SNP carrier status on inflammation and fibrosis in left atrial appendage tissue. METHODS AND RESULTS: Carrier status of 10 AF-associated SNPs was evaluated on DNA extracted from left atrial appendage tissue in 176 individuals (120 with AF)...
August 30, 2016: Journal of Cardiovascular Electrophysiology
Mikhael F El-Chami, Faisal M Merchant, Paige Smith, Mathew Levy, Angela Gill Nelms, John Merlino, John Puskas, Angel R Leon
BACKGROUND: New-onset postoperative atrial fibrillation (POAF) occurs in up to 30% of patients undergoing coronary artery bypass grafting (CABG). POAF is associated with short- and long-term mortality. METHODS: To identify the true incidence and time course of recurrent atrial fibrillation (AF) in patients with POAF, we prospectively assigned 23 patients with POAF to receive an implantable loop recorder (ILR; Medtronic Inc., Minneapolis, MN, USA) for the detection of recurrent AF...
October 2016: Pacing and Clinical Electrophysiology: PACE
Svetlana I Sazonova, Julia N Ilyushenkova, Yuri B Lishmanov, Roman E Batalov, Alexey E Sazonov, Ludmila A Larionova, Evgeniy A Nesterov, Natalia V Varlamova, Julia V Rogovskaya, Tatyana A Shelkovnikova, Sergey V Popov
OBJECTIVE: Aim was to study the performance of single-photon emission computed tomography (SPECT) with (99m)Tc-pyrophosphate ((99m)Tc-PYP) in diagnostics of chronic latent inflammation in myocardium of patients with atrial fibrillation (AF). METHODS: The research included 70 patients (the average age of 49.3 ± 10.2 years) with persistent form of idiopathic AF. All patients underwent myocardium SPECT with (99m)Tc-PYP and cardiac magnetic resonance imaging (CMR) before the ablation...
August 24, 2016: Annals of Nuclear Medicine
Uğur Canpolat, Kudret Aytemir, Tuncay Hazirolan, Necla Özer, Ali Oto
BACKGROUND: Left atrial (LA) fibrosis is known as the hallmark for arrhythmogenic substrate in atrial fibrillation (AF). Quantification of LA fibrosis by using delayed-enhanced magnetic resonance imaging (DE-MRI) in AF patients is a pioneering noninvasive technique. Vitamin D (vitD) negatively regulates the renin-angiotensin system, binds to vitD receptors on cardiac myocytes, and has antioxidant properties that may ameliorate the inflammation and proarrhythmic substrate formation. However, its role in LA fibrosis is unclear...
August 20, 2016: Journal of Cardiology
Farhan Shahid, Gregory Y H Lip, Eduard Shantsila
No abstract text is available yet for this article.
May 7, 2016: Canadian Journal of Cardiology
Wesley T O'Neal, Sanjay Venkatesh, Stephen T Broughton, William F Griffin, Elsayed Z Soliman
Atrial fibrillation (AF) is the most common sustained arrhythmia encountered in clinical practice, and it places a substantial burden on the health care system. Despite improvements in our understanding of AF pathophysiology, we have yet to develop targeted preventive therapies. Recently, numerous biological markers have been identified to aid in the prediction of future AF events. Subclinical markers of atrial stress, inflammation, endothelial dysfunction, kidney dysfunction, and atherosclerosis have been linked to AF...
2016: Vascular Health and Risk Management
O L Bokeriya, A A Akhobekov, V A Shvarts, L A Glushko, T G Le
BACKGROUND: Atrial fibrillation (AF) develops in the early postoperative period in each third patient undergoing coronary bypass surgery (CBPS). Multifactorial pathogenesis of postoperative AF is unclear. The concept of postoperative inflammation as a potential basic mechanism of this condition has been implied in many studies. Pre- and postoperative treatment with antiinflammatory statins proved beneficial as a means for reducing the frequency of AF. MATERIALS AND METHODS: The meta-analysis is based on the results of 15 clinical studies carried out in the last 15 years...
2016: Klinicheskaia Meditsina
Ozge Altintas, Abdurrahman Tasal, Elvin Niftaliyev, Okkes Taha Kucukdagli, Talip Asil
OBJECTIVES: In this study, we aimed to evaluate whether the inflammation as measured by increased platelet to lymphocyte ratio (PLR) predispose to silent infarcts in patients with paroxysmal atrial fibrillation (PAF). METHODS: The present study investigated a total of 48 new diagnosed patients with PAF who had no signs of stroke. PLR, which was calculated as the ratio of the platelet count to the lymphocyte count, C-reactive protein and erythrocyte sedimentation rate were measured due to evaluate inflammatory state...
September 2016: Neurological Research
Patompong Ungprasert, Narat Srivali, Wonngarm Kittanamongkolchai
BACKGROUND AND OBJECTIVES: Patients with psoriasis might have a higher risk of developing atrial fibrillation as a result of chronic inflammation. This study aimed to investigate this association by comprehensively reviewing all available evidence. METHODS: We conducted a systematic review and meta-analysis of cohort studies that reported relative risk, hazard ratio, incidence ratio or standardized incidence ratio with 95% confidence intervals comparing the risk of incident atrial fibrillation in patients with psoriasis versus participants without psoriasis...
September 2016: Indian Journal of Dermatology, Venereology and Leprology
Evin Bozçalı, Veli Polat, Gönül Kutlu, Selçuk Opan, Nurcan Paker, Turgut Uygun, Barış Ökçün, Osman Karakaya
OBJECTIVE: Inflammation is thought to play a role in the pathogenesis of atrial fibrillation. The relationship between CD40 ligand (CD40L), a prothrombotic and proinflammatory molecule, and lone atrial fibrillation was presently investigated for the first time. Levels of serum CD40L were also tested, regarding potential to distinguish patients with lone atrial fibrillation from healthy individuals. METHODS: Presently included were 35 patients with lone persistent atrial fibrillation and a control group of 30 healthy individuals...
July 2016: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
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