keyword
Keywords Atrial fibrillation AND inflam...

Atrial fibrillation AND inflammation

https://read.qxmd.com/read/38525437/circulating-exosome-long-non-coding-rnas-are-associated-with-atrial-structural-remodeling-by-increasing-systemic-inflammation-in-atrial-fibrillation-patients
#1
JOURNAL ARTICLE
Yue Yuan, Xuejie Han, Xinbo Zhao, Haiyu Zhang, Asiia Vinograd, Xin Bi, Xiaoxu Duan, Yukai Cao, Qiang Gao, Jia Song, Li Sheng, Yue Li
BACKGROUND: Atrial fibrillation (AF) is the most common cardiac arrhythmia with severe clinical sequelae, but its genetic characteristic implicated in pathogenesis has not been completely clarified. Accumulating evidence has indicated that circulating exosomes and their carried cargoes, such as long non-coding RNAs (lncRNAs), involve in the progress of multiple cardiovascular diseases. However, their potential role as clinical biomarkers in AF diagnosis and prognosis remains unknown. METHODS: Herein, we conducted the sequence and bioinformatic analysis of circulating exosomes harvested from AF and sinus rhythm patients...
February 2024: Journal of Translational Internal Medicine
https://read.qxmd.com/read/38523340/lymphocytic-myocarditis-with-increased-left-ventricular-thickness-a-rare-presentation-mimicking-cardiac-amyloidosis
#2
JOURNAL ARTICLE
Xueting Duan, Liangzhen Qu, Han Chen
BACKGROUND Lymphocytic myocarditis is an inflammatory condition of the heart that may present with a wide spectrum of symptoms and signs, ranging from asymptomatic to life-threatening cardiogenic shock and ventricular arrhythmia. Lymphocytic myocarditis usually presents as chamber dilation. However, increased left ventricular thickness is relatively rare. We present a case of lymphocytic myocarditis with increased left ventricular thickness which mimics the presentation of cardiac amyloidosis. CASE REPORT An 80-year-old Chinese man presented to the emergency room due to recurrent chest tightness...
March 25, 2024: American Journal of Case Reports
https://read.qxmd.com/read/38521291/association-between-psoriasis-and-atrial-fibrillation-a-systematic-review-and-meta-analysis
#3
REVIEW
Hritvik Jain, Ramez M Odat, Aman Goyal, Jyoti Jain, Debankur Dey, Mushood Ahmed, Amanpreet Singh Wasir, Siddhant Passey, Shrey Gole
INTRODUCTION: Psoriasis is a prevalent inflammatory skin condition characterized by erythematous plaques with scaling. Recent research has demonstrated an increased risk of cardiovascular diseases in patients with psoriasis; however, current evidence on atrial fibrillation (AF) risk in psoriasis is limited. MATERIALS AND METHODS: A systematic literature search was performed on major bibliographic databases to retrieve studies that evaluated AF risk in patients with psoriasis...
March 21, 2024: Current Problems in Cardiology
https://read.qxmd.com/read/38515030/association-of-red-cell-distribution-width-albumin-ratio-and-in-hospital-mortality-in-patients-with-atrial-fibrillation-base-on-medical-information-mart-for-intensive-care-iv-database
#4
JOURNAL ARTICLE
Li-Ya Pan, Jing Song
BACKGROUND: Atrial fibrillation (AF) is a common cardiac arrhythmia. The ratio of red cell distribution width (RDW) to albumin has been recognized as a reliable prognostic marker for poor outcomes in a variety of diseases. However, the evidence regarding the association between RDW to albumin ratio (RAR) and in hospital mortality in patients with AF admitted to the Intensive Care Unit (ICU) currently was unclear. The purpose of this study was to explore the association between RAR and in hospital mortality in patients with AF in the ICU...
March 21, 2024: BMC Cardiovascular Disorders
https://read.qxmd.com/read/38510143/exploring-the-role-of-epicardial-adipose-tissue-derived-extracellular-vesicles-in-cardiovascular-diseases
#5
REVIEW
Alessandra Stefania Rizzuto, Guido Gelpi, Andrea Mangini, Stefano Carugo, Massimiliano Ruscica, Chiara Macchi
Epicardial adipose tissue (EAT) is a fat depot located between the myocardium and the visceral layer of the epicardium, which, owing to its location, can influence surrounding tissues and can act as a local transducer of systemic inflammation. The mechanisms upon which such influence depends on are however unclear. Given the role EAT undoubtedly has in the scheme of cardiovascular diseases (CVDs), understanding the impact of its cellular components is of upmost importance. Extracellular vesicles (EVs) constitute promising candidates to fill the gap in the knowledge concerning the unexplored mechanisms through which EAT promotes onset and progression of CVDs...
April 19, 2024: IScience
https://read.qxmd.com/read/38508850/genetic-factors-altering-immune-responses-in-atrial-fibrillation-jacc-review-topic-of-the-week
#6
REVIEW
Sandro Ninni, David Dombrowicz, Menno de Winther, Bart Staels, David Montaigne, Stanley Nattel
Atrial fibrillation (AF) is the most common cardiac arrhythmia worldwide and is associated with a range of adverse clinical outcomes. Accumulating evidence points to inflammatory processes resulting from innate immune responses as a cornerstone in AF pathogenesis. Genetic and epigenetic factors affecting leukocytes have been identified as key modulators of the inflammatory response. Inherited variants in genes encoding proteins involved in the innate immune response have been associated with increased risk for AF recurrence and stroke in AF patients...
March 26, 2024: Journal of the American College of Cardiology
https://read.qxmd.com/read/38506343/prophylactic-corticosteroids-for-cardiopulmonary-bypass-in-adult-cardiac-surgery
#7
REVIEW
Riccardo Giuseppe Abbasciano, Guido Maria Olivieri, Rachel Chubsey, Francesca Gatta, Nathan Tyson, Keertana Easwarakumar, Daniel P Fudulu, Roberto Marsico, Markus Kofler, Ghazi Elshafie, Florence Lai, Mahmoud Loubani, Simon Kendall, Mustafa Zakkar, Gavin J Murphy
BACKGROUND: Cardiac surgery triggers a strong inflammatory reaction, which carries significant clinical consequences. Corticosteroids have been suggested as a potential perioperative strategy to reduce inflammation and help prevent postoperative complications. However, the safety and effectiveness of perioperative corticosteroid use in adult cardiac surgery is uncertain. This is an update of the 2011 review with 18 studies added. OBJECTIVES: Primary objective: to estimate the effects of prophylactic corticosteroid use in adults undergoing cardiac surgery with cardiopulmonary bypass on the: - co-primary endpoints of mortality, myocardial complications, and pulmonary complications; and - secondary outcomes including atrial fibrillation, infection, organ injury, known complications of steroid therapy, prolonged mechanical ventilation, prolonged postoperative stay, and cost-effectiveness...
March 20, 2024: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/38497478/exercise-dependent-modulation-of-immunological-response-pathways-in-endurance-athletes-with-and-without-atrial-fibrillation
#8
JOURNAL ARTICLE
David Dorian, Dakota Gustafson, Ryan Quinn, Robert F Bentley, Paul Dorian, Jack M Goodman, Jason E Fish, Kim A Connelly
BACKGROUND: Atrial fibrillation (AF) is a common arrhythmia characterized by uncoordinated atrial electrical activity. Lone AF occurs in the absence of traditional risk factors and is frequently observed in male endurance athletes, who face a 2- to 5-fold higher risk of AF compared with healthy, moderately active males. Our understanding of how endurance exercise contributes to the pathophysiology of lone AF remains limited. This study aimed to characterize the circulating protein fluctuations during high-intensity exercise as well as explore potential biomarkers of exercise-associated AF...
March 19, 2024: Journal of the American Heart Association
https://read.qxmd.com/read/38494555/epicardial-adipose-tissue-density-predicts-the-presence-of-atrial-fibrillation-and-its-recurrence-after-catheter-ablation-three-dimensional-reconstructed-image-analysis
#9
JOURNAL ARTICLE
Minoru Nodera, Tomokazu Ishida, Kanae Hasegawa, Shota Kakehashi, Moe Mukai, Daisetsu Aoyama, Shinsuke Miyazaki, Hiroyasu Uzui, Hiroshi Tada
Epicardial adipose tissue (EAT) induces inflammation in the atria and is associated with atrial fibrillation (AF). Several studies have examined the relationship between EAT volume (EAT-V) and density (EAT-D) and the presence of AF after catheter ablation. However, conclusions have been inconsistent. This study included 43 consecutive patients who underwent catheter ablation for AF and 30 control patients. EAT-V and EAT-D around the entire heart, entire atrium, left atrium (LA), and right atrium (RA) were measured in detail using reconstructed three-dimensional (3D) EAT images from dual-source computed tomography (CT)...
March 18, 2024: Heart and Vessels
https://read.qxmd.com/read/38477580/epicardial-adipose-tissue-a-precise-biomarker-for-cardiovascular-risk-metabolic-diseases-and-target-for-therapeutic-interventions
#10
JOURNAL ARTICLE
Aleksander Bogdański, Piotr Niziołek, Stanisław Kopeć, Małgorzata Moszak
Epicardial adipose tissue (EAT) is located between the heart muscle and visceral pericardium, where it has direct contact with coronary blood vessels. Elevated thickness of this tissue can induce local inflammation affecting the myocardium and the underlying coronary arteries, contributing to various cardiovascular diseases such as coronary artery disease, atrial fibrillation, or heart failure with preserved ejection fraction. Recent studies have identified EAT thickness as a simple and reliable biomarker for certain cardiovascular outcomes...
March 13, 2024: Cardiology in Review
https://read.qxmd.com/read/38472506/pathophysiology-and-clinical-relevance-of-atrial-myopathy
#11
REVIEW
Michiel R L Tubeeckx, Gilles W De Keulenaer, Hein Heidbuchel, Vincent F M Segers
Atrial myopathy is a condition that consists of electrical, structural, contractile, and autonomic remodeling of the atria and is the substrate for development of atrial fibrillation, the most common arrhythmia. Pathophysiologic mechanisms driving atrial myopathy are inflammation, oxidative stress, atrial stretch, and neurohormonal signals, e.g., angiotensin-II and aldosterone. These mechanisms initiate the structural and functional remodeling of the atrial myocardium. Novel therapeutic strategies are being developed that target the pathophysiologic mechanisms of atrial myopathy...
March 12, 2024: Basic Research in Cardiology
https://read.qxmd.com/read/38443672/hfpef-as-systemic-disease-insight-from-a-diagnostic-prediction-model-reminiscent-of-systemic-inflammation-and-organ-interaction-in-hfpef-patients
#12
JOURNAL ARTICLE
Rong Zhou, Yi-Yuan Xia, Zheng Li, Li-Da Wu, Yi Shi, Zhi-Yu Ling, Jun-Xia Zhang
Systemic inflammation and reciprocal organ interactions are associated with the pathophysiology of heart failure with preserved ejection fraction (HFpEF). However, the clinical value, especially the diagnositc prediction power of inflammation and extra-cardiac organ dysfunction for HfpEF is not explored. In this cross-sectional study, 1808 hospitalized patients from January 2014 to June 2022 in ChiHFpEF cohort were totally enrolled according to inclusion and exclusion criteria. A diagnostic model with markers from routine blood test as well as liver and renal dysfunction for HFpEF was developed using data from ChiHFpEF-cohort by logistic regression and assessed by receiver operating characteristic curve (ROC) and Brier score...
March 5, 2024: Scientific Reports
https://read.qxmd.com/read/38436184/the-relationship-between-hemoglobin-to-red-cell-distribution-width-rdw-ratio-hrr-and-mortality-in-stroke-patients
#13
JOURNAL ARTICLE
A Eyiol, B Ertekin
OBJECTIVE: In recent years, many studies have shown that hemoglobin to red cell distribution width ratio (HRR), which is the ratio of hemoglobin (Hb) to red cell distribution width (RDW), is associated with inflammation. Inflammation is linked to both the development of stroke and the severe effects that follow. Therefore, the relationship between the HRR and mortality in patients with stroke was investigated in our study. PATIENTS AND METHODS: 127 stroke patients who visited the emergency department between March 1, 2023, and June 1, 2023, were retrospectively evaluated...
February 2024: European Review for Medical and Pharmacological Sciences
https://read.qxmd.com/read/38435383/association-between-inflammation-markers-and-all-cause-mortality-in-critical-ill-patients-with-atrial-fibrillation-analysis-of-the-multi-parameter-intelligent-monitoring-in-intensive-care-mimic-iv-database
#14
JOURNAL ARTICLE
Qian Li, Jian Nie, Miaomiao Cao, Chaodi Luo, Chaofeng Sun
BACKGROUND: Inflammation is related to cardiovascular disease. Among the many inflammatory markers, neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammatory index (SII) were considered as novel predictors for atherosclerosis outcomes. We aimed to investigate the impact of these inflammatory markers on the prognosis of patients with atrial fibrillation (AF). METHODS: We obtained data on AF patients from the Medical Information Mart for Intensive Care (MIMIC)-IV database...
April 2024: IJC Heart & Vasculature
https://read.qxmd.com/read/38433463/systemic-immune-inflammation-index-as-a-novel-hematological-marker-for-predicting-the-recurrence-of-deep-venous-thrombosis
#15
JOURNAL ARTICLE
Ibrahim Donmez, Ayhan Muduroglu
OBJECTIVE: To determine whether there was a possible predictive relationship between systemic immune-inflammation index (SII) and recurrence of deep venous thrombosis (DVT). METHODS: A total of 231 patients with DVT who met the study criteria and whose data could be accessed were enrolled to this retrospective single-centered cross-sectional study. Of them 26 patients with DVT recurrence consisted of the study group (Group 1) while remaining 205 cases without recurrence were considered as the control population (Group 2)...
March 3, 2024: Vascular
https://read.qxmd.com/read/38425104/aldosterone-effect-on-cardiac-structure-and-function
#16
JOURNAL ARTICLE
Ekhlas Mahmoud Al-Hashedi, Fuad A Abdu
BACKGROUND: Cardiac remodelling could be a key mechanism in aldosteronemediated cardiovascular morbidity and mortality. Experimental and clinical evidence has demonstrated that aldosterone causes cardiac structural remodelling and dysfunction by its profibrotic and pro-hypertrophic effects, which result mainly from the direct effects on myocardial collagen deposition, inflammation, and oxidative stress. Clinical studies have investigated the aldosterone effects on the heart in different clinical conditions, including general population, essential hypertension, primary aldosteronism, heart failure, and atrial fibrillation...
February 29, 2024: Current Cardiology Reviews
https://read.qxmd.com/read/38422952/association-of-a-low-inflammatory-diet-with-survival-among-adults-the-role-of-cardiometabolic-diseases-and-lifestyle
#17
JOURNAL ARTICLE
Huiying Da, Rongrong Yang, Jiaxin Liang, Jiao Wang, Wenzhe Yang, Michelle M Dunk, Xiuying Qi, Weili Xu
BACKGROUND & AIMS: Evidence on the association between dietary inflammation and longevity is limited. We aimed to examine the association of a low-inflammatory diet with mortality and longevity, and to explore whether cardiometabolic diseases (CMDs) and lifestyle factors may play a role in this association. METHODS: Within the UK Biobank, 188,443 participants aged 39-72 years (mean 56.07) were followed for up to 16 years to detect survival status from the death registry...
February 22, 2024: Clinical Nutrition
https://read.qxmd.com/read/38415142/the-relationship-between-right-atrial-wall-inflammation-and-poor-prognosis-of-atrial-fibrillation-based-on-18-f-fdg-positron-emission-tomography-computed-tomography
#18
JOURNAL ARTICLE
Peng Wan, Wenji Yu, Lishang Zhai, Bo Qian, Feifei Zhang, Bao Liu, Jianfeng Wang, Xiaoliang Shao, Yunmei Shi, Qi Jiang, Mengfei Wang, Shan Shao, Yuetao Wang
BACKGROUND: Atrial fibrillation (AF) has been identified to increase stroke risk, even after oral anticoagulants (OACs), and the recurrence rate is high after radiofrequency catheter ablation (RFCA). Inflammation is an essential factor in the occurrence and persistence of AF. 18 F-fluorodeoxyglucose (18 F-FDG) positron emission tomography/computed tomography (PET/CT) is an established molecular imaging modality to detect local inflammation. We aimed to investigate the relationship between atrial inflammatory activity and poor prognosis of AF based on 18 F-FDG PET/CT...
February 1, 2024: Quantitative Imaging in Medicine and Surgery
https://read.qxmd.com/read/38405916/unbiased-characterization-of-atrial-fibrillation-phenotypic-architecture-provides-insight-to-genetic-liability-and-clinically-relevant-outcomes
#19
Giovanni Davogustto, Shilin Zhao, Yajing Li, Eric Farber-Eger, Brandon D Lowery, Lauren Lee Shaffer, Jonathan D Mosley, M Benjamin Shoemaker, Yaomin Xu, Dan M Roden, Quinn S Wells
BACKGROUND: Atrial Fibrillation (AF) is a common and clinically heterogeneous arrythmia. Machine learning (ML) algorithms can define data-driven disease subtypes in an unbiased fashion, but whether the AF subgroups defined in this way align with underlying mechanisms, such as high polygenic liability to AF or inflammation, and associate with clinical outcomes is unclear. METHODS: We identified individuals with AF in a large biobank linked to electronic health records (EHR) and genome-wide genotyping...
February 14, 2024: medRxiv
https://read.qxmd.com/read/38377486/lnk-sh2b3-loss-of-function-increases-susceptibility-to-murine-and-human-atrial-fibrillation
#20
JOURNAL ARTICLE
Matthew B Murphy, Zhenjiang Yang, Tuerdi Subati, Eric Farber-Eger, Kyungsoo Kim, Daniel J Blackwell, Matthew R Fleming, Joshua M Stark, Joseph C Van Amburg, Kaylen K Woodall, Justin P Van Beusecum, Vineet Agrawal, Charles D Smart, Ashley Pitzer, James B Atkinson, Agnes B Fogo, Julie A Bastarache, Annet Kirabo, Quinn S Wells, Meena S Madhur, Joey V Barnett, Katherine T Murray
AIMS: The lymphocyte adaptor protein (LNK) is a negative regulator of cytokine and growth factor signaling. The rs3184504 variant in SH2B3 reduces LNK function and is linked to cardiovascular, inflammatory, and hematologic disorders including stroke. In mice, deletion of Lnk causes inflammation and oxidative stress. We hypothesized that Lnk-/- mice are susceptible to atrial fibrillation (AF) and that rs3184504 is associated with AF and AF-related stroke in humans. During inflammation, reactive lipid dicarbonyls are a major component of oxidative injury, and we further hypothesized that these mediators are critical drivers of the AF substrate in Lnk-/- mice...
February 20, 2024: Cardiovascular Research
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