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Venous leg ulcers

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https://www.readbyqxmd.com/read/29785810/adjunctive-therapy-for-healing-venous-leg-ulcers
#1
A Ferris, K Harding
No abstract text is available yet for this article.
May 2018: British Journal of Dermatology
https://www.readbyqxmd.com/read/29762309/effectiveness-of-extracellular-matrix-dressings-and-topical-agents-in-the-treatment-of-leg-ulcers-a-systematic-review-protocol
#2
Francislene de Fátima Cordeiro Petz, Marineli Joaquim Meier, Hellen Roehrs, Franciele Soares Pott
The objective of this review is to synthesize the best available evidence on the effectiveness of the application of extracellular matrix products as dressings or in topical form as treatment for venous, arterial and mixed leg ulcers, compared to compression therapy alone, any type of dressings and topical agents, or placebos in adults over 18 years in any care setting.
May 2018: JBI Database of Systematic Reviews and Implementation Reports
https://www.readbyqxmd.com/read/29738296/microcurrent-as-an-adjunct-therapy-to-accelerate-chronic-wound-healing-and-reduce-patient-pain
#3
Harikrishna K R Nair
OBJECTIVE: The primary aim is to assess the efficacy of microcurrent, a form of electrical stimulation, as an adjunct therapy in accelerating healing in chronic wounds by reducing wound size and pain level. The secondary aim is to assess the qualitative changes in these parameters: inflammatory symptoms, vasodilation, sleep quality, gait and frequency of bowel movement. METHOD: Eligible patients with chronic wounds were enrolled between March and June 2016, from the Wound Care Unit, Hospital Kuala Lumpur in this consecutive case series...
May 2, 2018: Journal of Wound Care
https://www.readbyqxmd.com/read/29735019/supplementation-with-eicosapentaenoic-acid-and-docosahexaenoic-acid-reduces-high-levels-of-circulating-proinflammatory-cytokines-in-aging-adults-a-randomized-controlled-study
#4
Alai Tan, Brent Sullenbarger, Ruchika Prakash, Jodi C McDaniel
BACKGROUND: High levels of circulating proinflammatory cytokines are characteristic of inflammaging, a term coined to describe age-related chronic systemic inflammation involved in the etiology of many age-related disorders including nonhealing wounds. Some studies have shown that supplementing diets with n-3 polyunsaturated fatty acids (eicosapentaenoic acid [EPA] and docosahexaenoic acid [DHA]) lowers systemic levels of key proinflammatory cytokines associated with inflammaging. However, findings from the few studies that have focused exclusively on older adults are inconclusive...
May 2018: Prostaglandins, Leukotrienes, and Essential Fatty Acids
https://www.readbyqxmd.com/read/29720376/dressings-for-venous-leg-ulcers
#5
Sophia Tate, Annie Price, Keith Harding
No abstract text is available yet for this article.
May 2, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29718816/a-post-marketing-surveillance-study-of-chronic-wounds-treated-with-a-native-collagen-calcium-alginate-dressing
#6
Matthew Sabo, Lam Le, Raphael A Yaakov, Marissa Carter, Thomas E Serena
Chronic wounds (ie, wounds that fail to progress through a normal, orderly, timely sequence of repair) continue to pose significant clinical and economic burdens. A prospective, descriptive, 3-week post-marketing surveillance study was conducted across 3 wound care centers in the United States to evaluate the effectiveness of a collagen calcium alginate dressing on chronic wounds in conjunction with standard care (SC) practices (eg, offloading, debridement, compression) to support healing. Eligible participants had to be >18 years of age, have at least 1 chronic wound, and no known sensitivity to collagen...
April 2018: Ostomy/wound Management
https://www.readbyqxmd.com/read/29708541/deep-vein-thrombosis-induced-by-stasis-in-mice-monitored-by-high-frequency-ultrasonography
#7
Ryan N Rys, Mark D Blostein, Catherine A Lemarié
Venous thrombosis is a common condition affecting 1 - 2% of the population, with an annual incidence of 1 in 500. Venous thrombosis can lead to death through pulmonary embolism or results in the post-thrombotic syndrome, characterized by chronic leg pain, swelling, and ulceration, or in chronic pulmonary hypertension resulting in significant chronic respiratory compromise. This is the most common cardiovascular disease after myocardial infarction and ischemic stroke and is a clinical challenge for all medical disciplines, as it can complicate the course of other disorders such as cancer, systemic disease, surgery, and major trauma...
April 13, 2018: Journal of Visualized Experiments: JoVE
https://www.readbyqxmd.com/read/29692349/early-endovenous-ablation-achieves-faster-healing-of-venous-leg-ulcers-than-compression-therapy-study-finds
#8
Susan Mayor
No abstract text is available yet for this article.
April 24, 2018: BMJ: British Medical Journal
https://www.readbyqxmd.com/read/29689069/health-related-quality-of-life-in-patients-with-venous-leg-ulcer-treated-in-primary-care-in-brazil-and-portugal
#9
Sandra Maria da Solidade Simões de Oliveira Torres, Rhayssa de Oliveira E Araújo, Isabelle Katherinne Fernandes Costa, Manuela Pinto Tibúrcio, Amanda Jessica Gomes de Sousa, Aline Maino Pergola-Marconato, Thalyta Cristina Mansano-Schlosser, Marina de Góes Salvetti, Felismina Rosa Parreira Mendes, Gilson de Vasconcelos Torres, Eulalia Maria Chaves Maia
BACKGROUND: Venous ulcers constitute an important public health problem as they can cause disability with consequences for multiple dimensions of quality of life. OBJECTIVE: To describe the quality of life in patients with venous leg ulcer treated in primary care in two cities from Brazil and Portugal. METHODS: This was a cross-sectional comparative study with a non-probabilistic sample of 171 patients with venous leg ulcers who were treated in primary care in two cities from Brazil and Portugal, namely, Natal and Évora...
2018: PloS One
https://www.readbyqxmd.com/read/29688123/a-randomized-trial-of-early-endovenous-ablation-in-venous-ulceration
#10
Manjit S Gohel, Francine Heatley, Xinxue Liu, Andrew Bradbury, Richard Bulbulia, Nicky Cullum, David M Epstein, Isaac Nyamekye, Keith R Poskitt, Sophie Renton, Jane Warwick, Alun H Davies
Background Venous disease is the most common cause of leg ulceration. Although compression therapy improves venous ulcer healing, it does not treat the underlying causes of venous hypertension. Treatment of superficial venous reflux has been shown to reduce the rate of ulcer recurrence, but the effect of early endovenous ablation of superficial venous reflux on ulcer healing remains unclear. Methods In a trial conducted at 20 centers in the United Kingdom, we randomly assigned 450 patients with venous leg ulcers to receive compression therapy and undergo early endovenous ablation of superficial venous reflux within 2 weeks after randomization (early-intervention group) or to receive compression therapy alone, with consideration of endovenous ablation deferred until after the ulcer was healed or until 6 months after randomization if the ulcer was unhealed (deferred-intervention group)...
April 24, 2018: New England Journal of Medicine
https://www.readbyqxmd.com/read/29675338/assessing-the-healing-of-venous-leg-ulcers-using-a-noncontact-near-infrared-optical-imaging-approach
#11
Jiali Lei, Suset Rodriguez, Maanasa Jayachandran, Elizabeth Solis, Katrina Epnere, Francisco Perez-Clavijo, Stephen Wigley, Anuradha Godavarty
Objective: Venous leg ulcers (VLUs) are one of the most common complications in lower extremity wounds. To date, clinicians employ visual inspection of the wound site during its healing process by monitoring surface granulation and reduction in wound size across weeks of treatment. In this study, a handheld near-infrared optical scanner (NIROS) has been developed at the Optical Imaging Laboratory to differentiate healing from nonhealing VLUs based on differences in blood flow to the wound and its surroundings...
April 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29660929/ecchymosis-a-novel-sign-in-patients-with-varicose-veins
#12
Ertan Yetkin, Mehmet Ileri, Johannes Waltenberger
BACKGROUND: In the absence of trauma, hematologic disease and anti-platelet use, no attention has been paid to elucidate the mechanism of ecchymosis. It has taken our attention that ecchymosis on lower limb might be a sign of varicose vein. Accordingly, we aimed to analyze and describe the frequency of leg symptoms and presence of ecchymosis in patients with varicose vein. MATERIALS AND METHODS: Four hundred and ninety four patients who had been diagnosed as having varicose vein or chronic venous insufficiency either by clinical examination or Doppler ultrasonography were included in the study...
2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29660917/medical-compression-stockings-reduce-hypertension-of-nailfold-capillaries-at-the-toe-of-patients-with-chronic-venous-insufficiency1
#13
Anja Oelert, Manuela Kittel, Martin Hahn, Hermann Haase, Michael Jünger
In five patients who suffered from chronic venous insufficiency clinical stage C4 (n = 3) and C6 (n = 2) the capillary blood pressure was measured twice by means of invasive direct cannulation of nailfold capillaries of the toe. During one measurement course the patients wore below knee medical compression stockings (40 mmHg) during the other they did not have compression therapy. With the patient in supine position, the CP was investigated by the servo-nulling technique under resting conditions and under dynamic conditions: the calf-muscle/ankle joint venous pump was simulated by means of inflating a blood pressure cuff, which surrounded the mid lower leg, to 60 mmHg for 60 s...
April 7, 2018: Clinical Hemorheology and Microcirculation
https://www.readbyqxmd.com/read/29644145/publicly-reported-wound-healing-rates-the-fantasy-and-the-reality
#14
REVIEW
Caroline E Fife, Kristen A Eckert, Marissa J Carter
Significance: We compare real-world data from the U.S. Wound Registry (USWR) with randomized controlled trials and publicly reported wound outcomes and develop criteria for honest reporting of wound outcomes, a requirement of the new Quality Payment Program (QPP). Recent Advances: Because no method has existed by which wounds could be stratified according to their likelihood of healing among real-world patients, practitioners have reported fantastically high healing rates. The USWR has developed several risk-stratified wound healing quality measures for diabetic foot ulcers (DFUs) and venous leg ulcers (VLUs) as part of its Qualified Clinical Data Registry (QCDR)...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29644144/comparative-effectiveness-of-a-bioengineered-living-cellular-construct-and-cryopreserved-cadaveric-skin-allograft-for-the-treatment-of-venous-leg-ulcers-in-a-real-world-setting
#15
Terry Treadwell, Michael L Sabolinski, Michelle Skornicki, Nathan B Parsons
Objective: A variety of advanced biological therapies are available for the treatment of chronic wounds such as venous leg ulcers (VLUs), but real-world comparative effectiveness data that can help guide decisions around treatments are currently lacking. Approach: This analysis was designed to compare the effectiveness of a bioengineered living cellular construct (BLCC) to a cryopreserved cadaveric skin allograft (CCSA) for the treatment of VLUs. Treatment records were collected from a large wound care-specific electronic medical record database on 717 patients (799 VLUs) receiving treatment at 177 wound care centers...
March 1, 2018: Advances in Wound Care
https://www.readbyqxmd.com/read/29607227/rivaroxaban-treatment-for-warfarin-refractory-thrombosis-in-a-patient-with-hereditary-protein-s-deficiency
#16
Koken Ameku, Mariko Higa
Protein S (PS) deficiency, an autosomal dominant hereditary thrombophilia, is more prevalent in East Asian populations than in Caucasians. PS-deficient patients have historically been administered a heparin product followed by warfarin for the treatment and secondary prevention of venous thromboembolism (VTE). However, warfarin can be ineffective or causes detrimental effects in rare cases. While direct oral anticoagulants (DOACs) are being increasingly used for the treatment and prevention of VTE, their efficacy in PS-deficient patients has not been established...
2018: Case Reports in Hematology
https://www.readbyqxmd.com/read/29601617/collagen-powder-in-wound-healing
#17
Penelope J Kallis, Adam J Friedman
Chronic wounds, such as pressure ulcers, diabetic foot ulcers, and venous leg ulcers, are associated with high costs, poor quality of life, and significant morbidity and mortality. A chronic wound develops when progression through the normal phases of wound healing goes awry, creating a hostile environment with elevated levels of pro-inflammatory cytokines, increased matrix metalloproteinases (MMPs), destruction of extracellular matrix (ECM) components, and diminished activity of growth factors and other soluble mediators...
April 1, 2018: Journal of Drugs in Dermatology: JDD
https://www.readbyqxmd.com/read/29600821/an-unusual-presentation-of-a-common-condition-allergic-contact-dermatitis
#18
Annie Price, Natalie M Stone, Keith G Harding
Allergic contact dermatitis commonly affects patients with chronic venous leg ulcers and can contribute to impaired wound healing. Many allergens have been identified, and despite the use of advanced dressings, the incidence of allergy has remained high. We discuss an unusual presentation of allergic contact dermatitis in a patient with a chronic wound. The patient's history was consistent with a recurrent venous leg ulcer, but on this occasion, the wound continued to deteriorate despite optimal treatment. This prompted further investigation, which included patch testing...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29600560/contact-sensitivity-in-patients-with-venous-leg-ulcer-a-multi-centric-indian-study
#19
Reena Rai, Manjunath M Shenoy, Vishalakshi Viswanath, Nilendu Sarma, Imran Majid, Sunil Dogra
Venous leg ulcers are the most common form of non-healing leg ulcers. They are subjected to treatments such as topical medications, dressings, and compression therapies. This can lead to exposure to a number of allergens with subsequent sensitisation and contact dermatitis of the regional skin. This may contribute to the poor ulcer healing. To detect the various contact sensitisers in patients with venous leg ulcers through patch testing, patients from 6 centres across India with venous leg ulcers of longer than 6 weeks duration were enrolled for the study...
March 30, 2018: International Wound Journal
https://www.readbyqxmd.com/read/29593807/enhanced-healing-and-anti-inflammatory-effects-of-a-carbohydrate-polymer-with-zinc-oxide-in-patients-with-chronic-venous-leg-ulcers-preliminary-results
#20
Mario Adan Moreno-Eutimio, Lorena Espinosa-Monroy, Tania Orozco-Amaro, Yessica Torres-Ramos, Araceli Montoya-Estrada, Juan Jose Hicks, Ernesto Rodríguez-Ayala, Pamela Del Moral, Jose Moreno, Jorge Cueto-García
Introduction: Insufficient wound healing related to chronic inflammation of chronic venous leg ulcers (CVUs) represents an important public health problem. The aim of this study was to evaluate the effects of a carbohydrate polymer with zinc oxide therapy on CVUs. Material and methods: Forty patients with CVUs were recruited for this study and were divided into a study group and control group. Patients In the study group were instructed to use venous compression treatment andtopical carbohydrate polymer with zinc oxide twice daily, while patients In the control group were treated with only venous compression treatment...
March 2018: Archives of Medical Science: AMS
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