keyword
https://read.qxmd.com/read/35600200/klippel-trenaunay-syndrome-case-series-from-a-university-hospital-of-nepal
#21
JOURNAL ARTICLE
Robin Man Karmacharya, Satish Vaidya, Swechha Bhatt, Ashish Tamang, Rohit Bhasink Shrestha, Niroj Bhandari, Bijaya Paudel, Manish Shah, Gaurav Nepal
Introduction: Klippel Trenaunay Syndrome (KTS) is a rare congenital malformation with capillary and venous malformations and soft tissue/bony overgrowth with or without lymphatic malformation. Cutaneous vascular stain, varicosities and tissue hypertrophy represent its main clinical features. Besides, the patient can develop thromboembolic pathologies, recurrent bouts of infection, stasis eczema, limb length discrepancy and intolerable pain typical of intraosseous involvement. Methods: Here, we report a case series of seven patients aged 10-45 who presented to our centre with clinical features suggestive of KTS...
June 2022: Annals of Medicine and Surgery
https://read.qxmd.com/read/34902109/cellulitis-a-review-of-current-practice-guidelines-and-differentiation-from-pseudocellulitis
#22
REVIEW
Michelle A Boettler, Benjamin H Kaffenberger, Catherine G Chung
Cellulitis, an infection involving the deep dermis and subcutaneous tissue, is the most common reason for skin-related hospitalization and is seen by clinicians across various disciplines in the inpatient, outpatient, and emergency room settings, but it can present as a diagnostic and therapeutic challenge. Cellulitis is a clinical diagnosis based on the history of present illness and physical examination and lacks a gold standard for diagnosis. Clinical presentation with acute onset of redness, warmth, swelling, and tenderness and pain is typical...
March 2022: American Journal of Clinical Dermatology
https://read.qxmd.com/read/34883526/injection-sclerotherapy-for-varicose-veins
#23
REVIEW
Ricardo de Ávila Oliveira, Rachel Riera, Vladimir Vasconcelos, Jose Cc Baptista-Silva
BACKGROUND: Varicose veins are enlarged and tortuous veins, affecting up to one-third of the world's population. They can be a cause of chronic venous insufficiency, which is characterised by oedema, pigmentation, eczema, lipodermatosclerosis, atrophie blanche, and healed or active venous ulcers. Injection sclerotherapy (liquid or foam) is widely used for treatment of varicose veins aiming to transform the varicose veins into a fibrous cord. However, there is limited evidence regarding its effectiveness and safety, especially in patients with more severe disease...
December 10, 2021: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/34608624/citric-acid-treatment-of-infected-venous-eczema-refractory-to-conventional-treatment-a-novel-approach
#24
JOURNAL ARTICLE
B S Nagoba, A S Rayate, N R Patil, A M Gavkare, S Chakote
The dermopathy in varicose veins occurs in continuum due to stasis hypertension. The main stay of treatment remains measures to counteract the stasis or appropriate surgical management, and application of various drugs and emollients. The infected/ weeping eczemas are challenging, requiring a fine balance of different topical therapies.
October 5, 2021: British Journal of Dermatology
https://read.qxmd.com/read/34171953/what-s-new-in-the-2020-update-of-the-ceap-classification-system-of-chronic-venous-disease
#25
JOURNAL ARTICLE
Dalibor Musil
The aim of the 2020 update of the CEAP (Clinical-Etiology-Anatomy-Pathophysiology) classification is provide the reproducibility of clinical findings between physicians, enable comparison of old and new versions of the CEAP classification, incorporate new evidence- based knowledge into the classification, and provide a balance between simple practical use and highly specific and detailed description of patient with chronic venous disease (CVD) in clinical and other studies. Clinical (C) classification remained unchanged and clinical definitions of all seven classes C0-C6 have been preserved...
2021: Vnitr̆ní Lékar̆ství
https://read.qxmd.com/read/33851208/maternal-late-pregnancy-serum-unmetabolized-folic-acid-concentrations-are-not-associated-with-infant-allergic-disease-a-prospective-cohort-study
#26
JOURNAL ARTICLE
Karen P Best, Tim J Green, Dian C Sulistyoningrum, Thomas R Sullivan, Susanne Aufreiter, Susan L Prescott, Maria Makrides, Monika Skubisz, Deborah L O'Connor, Debra J Palmer
BACKGROUND: The increase in childhood allergic disease in recent decades has coincided with increased folic acid intakes during pregnancy. Circulating unmetabolized folic acid (UMFA) has been proposed as a biomarker of excessive folic acid intake. OBJECTIVE: We aimed to determine if late-pregnancy serum UMFA and total folate concentrations were associated with allergic disease risk in the offspring at 1 y of age in a population at high risk of allergy. METHODS: The cohort consisted of 561 mother-infant pairs from Western Australia...
April 13, 2021: Journal of Nutrition
https://read.qxmd.com/read/33708219/treatment-of-chronic-venous-ulcers-with-heterologous-fibrin-sealant-a-phase-i-ii-clinical-trial
#27
JOURNAL ARTICLE
Luciana P F Abbade, Silvia Regina Catharino Sartori Barraviera, Maria Regina Cavariani Silvares, Ana Beatriz B de C O Lima, Gabriela R Haddad, Márcia A N Gatti, Natália Bronzatto Medolago, Márcia Tonin Rigotto Carneiro, Lucilene Delazari Dos Santos, Rui Seabra Ferreira, Benedito Barraviera
Background: Heterologous fibrin sealant (HFS) consists of a fibrinogen-rich cryoprecipitate extracted from Bubalus bubalis buffalo blood and a thrombin-like enzyme purified from Crotalus durissus terrificus snake venom. This study evaluated the safety and immunogenicity of HFS, estimated the best dose, and assessed its preliminary efficacy in the treatment of chronic venous ulcers (CVU). Methods: A phase I/II non-randomized, single-arm clinical trial was performed on 31 participants, accounting for a total of 69 active CVUs...
2021: Frontiers in Immunology
https://read.qxmd.com/read/33648480/histological-chorioamnionitis-is-associated-with-an-increased-risk-of-wheezing-in-preterm-children-less-than-34-gestational-weeks
#28
JOURNAL ARTICLE
Xiaoli Wang, Haiyuan Li, Qianqian Zhang, Qianwen Shen, Dan Zhu, Hong Li, Zheng Tang, Jiuru Zhao, Zhiwei Liu
BACKGROUND: Chorioamnionitis is associated with various neonatal short- and long-term morbidities. The effect of chorioamnionitis on premature children's outcomes remains controversial. The aim of this study is to investigate the relationship between histological chorioamnionitis (HCA) and physiological development, wheezing, and atopic diseases in preterm children. METHODS: Singleton, preterm children (< 34 weeks), whose mother underwent pathological placental examinations, were retrospectively enrolled and the outcomes were assessed at 24-40 months during follow-up...
March 1, 2021: BMC Pediatrics
https://read.qxmd.com/read/33176944/-bacterial-acute-non-necrosing-cellulitis-erysipelas-in-adult
#29
JOURNAL ARTICLE
F Dezoteux, D Staumont-Sallé
Erysipelas is defined by a sudden onset (with fever) preceding the appearance of a painful, infiltrated, erythematous plaque, accompanied by regional lymphadenopathy. It is usually localized on the lower limbs, but it can occur on the face. It is due to β-hemolytic streptococcus A and more rarely to staphylococcus aureus. It is important to establish the diagnosis and eliminate the non-bacterial causes of inflammatory edema. The other diagnoses frequently found are contact eczema, acute arthritis, bursitis, inflammatory flare-up of chronic dermohypodermitis of venous origin, flare-up of chronic multifactorial eczema (venous insufficiency, vitamin deficiencies, senile xerosis and/or contact eczema), rare familial periodic fevers, rare neutrophilic dermatoses or eosinophilic cellulitis...
March 2021: La Revue de Médecine Interne
https://read.qxmd.com/read/32926462/pooled-safety-analysis-of-baricitinib-in-adult-patients-with-atopic-dermatitis-from-8-randomized-clinical-trials
#30
JOURNAL ARTICLE
T Bieber, J P Thyssen, K Reich, E L Simpson, N Katoh, A Torrelo, M De Bruin-Weller, D Thaci, R Bissonnette, M Gooderham, J Weisman, F Nunes, D Brinker, M Issa, K Holzwarth, M Gamalo, E Riedl, J Janes
BACKGROUND: Janus kinase (JAK) inhibition is a new mode of action in atopic dermatitis (AD); clarity about drug class safety considerations in the context of AD is important. Baricitinib, an oral, reversible, selective inhibitor of JAK1/JAK2, is in late-stage development for adult patients with moderate-to-severe AD. OBJECTIVE: To report pooled safety data for baricitinib in patients with moderate-to-severe AD in the clinical development program including long-term extension (LTE) studies...
February 2021: Journal of the European Academy of Dermatology and Venereology: JEADV
https://read.qxmd.com/read/32402427/update-of-the-sfmv-french-society-of-vascular-medicine-guidelines-on-the-conditions-and-safety-measures-necessary-for-thermal-ablation-of-the-saphenous-veins-and-proposals-for-unresolved-issues
#31
JOURNAL ARTICLE
S Gracia, G Miserey, J Risse, F Abbadie, J F Auvert, B Chauzat, P Combes, D Creton, O Creton, L Da Mata, A Diard, P Giordana, M Josnin, O Keïta-Perse, A Lasheras, P Ouvry, O Pichot, S Skopinski, G Mahé
Venous insufficiency is a very common disease affecting about 25% of the French population (if we combine all stages of its progression). It is a complex disease and its aetiology has not yet been fully elucidated. Some of its causes are well known, such as valvular dysfunction, vein wall defect, and the suctioning effect common to all varicose veins. These factors are generally associated and together lead to dysfunction of one or more of the saphenous veins. Saphenous vein dysfunction is revealed by ultrasound scan, a reflux lasting more than 0...
May 2020: Journal de Médecine Vasculaire
https://read.qxmd.com/read/32284801/the-risk-factors-of-lower-limb-cellulitis-a-case-control-study-in-a-tertiary-centre
#32
JOURNAL ARTICLE
M N Norazirah, I S Khor, J Adawiyah, A M Tamil, M N Azmawati
Introduction: Lower limb cellulitis is a common superficial skin infection that leads to morbidity and mortality. Cellulitis risk factors have been well studied in many countries, but to date, not in Malaysia. Geographical and climate variables may affect risk factors. Early identification of the preventable risk factors is vital to prevent cellulitis and improve holistic patient care. Objective: To determine the risk factors of lower limb cellulitis amongst hospitalized patients at a tertiary center...
2020: Malaysian Family Physician
https://read.qxmd.com/read/31531971/compression-therapy-for-treating-post-thrombotic-syndrome
#33
JOURNAL ARTICLE
Sara Azirar, Diebrecht Appelen, Martin H Prins, Martino Ham Neumann, Adriaan Np de Feiter, Dinanda N Kolbach
BACKGROUND: Post-thrombotic syndrome (PTS) is a long-term complication of deep vein thrombosis (DVT) characterised by chronic complaints such as oedema and skin changes including; venous ectasia, varicose veins, redness, eczema, hyperpigmentation, and in severe cases fibrosis of the subcutaneous adipose in the affected limb. These chronic complaints are the effects of venous outflow restriction that can cause symptoms such as heaviness, itching, pain, cramps, and paraesthesia. Twenty to fifty percent of people with DVT develop post-thrombotic complications...
September 18, 2019: Cochrane Database of Systematic Reviews
https://read.qxmd.com/read/31503251/-diosmin-containing-phlebotropic-drugs-in-varicose-eczema
#34
JOURNAL ARTICLE
D V Rodnyansky, A A Fokin
AIM: The purpose of the study was to examine the effect of diosmine-based phlebotropic drugs on dynamics of regress of varicose eczema in patients with chronic venous diseases, to compare their objective complaints and subjective symptoms before and after treatment, to determine the time of improvement. PATIENTS AND METHODS: The study enrolled a total of 80 patients presenting with chronic venous diseases complicated by varicose eczema (CEAP class C4A). The patients of the Study Group received combined treatment: elastic compression of lower extremities, phlebotropic agents (diosmin 450 mg + hesperidin 50 mg, 'Venarus' (manufactured by the Limited Liability Company 'Obolenskoe', Russia) and a dermatologist's prescribed topical treatment...
2019: Angiology and Vascular Surgery
https://read.qxmd.com/read/31166791/skin-considerations-for-older-adults-with-wounds
#35
JOURNAL ARTICLE
Samantha Holloway
Ageing leads to a number of skin changes that not only place an older adult at risk of tissue damage, but can present as peri-wound problems for those with existing wounds, for example, incontinence-associated and moisture-associated dermatitis in individuals with pressure ulcers. Older adults with venous disease experience skin changes concomitant with venous hypertension, making the skin more at risk of breakdown, specifically the common complications of lipodermatosclerosis and venous eczema. In individuals with diabetic foot disease, skin changes related to autonomic neuropathy mean patients can experience dry skin that cracks easily, placing them at higher risk of infection...
June 1, 2019: British Journal of Community Nursing
https://read.qxmd.com/read/30297371/unilateral-leg-swelling-in-an-infant
#36
JOURNAL ARTICLE
Shilpa Shah, Sarah Berry, Laura Bingham, Gillian Rea
An 8-month-old boy presented with a week's history of left lower limb swelling. He was apyrexic, well and developmentally age appropriate. He was born at 35+5 via by C-section for breech presentation, weighing 3.47 kg (97th centile).His left calf measured 21.5 cm and the right calf 19.5 cm. The overlying skin showed mild eczema. There was no circulatory compromise of the left leg, and he was systemically well.X-rays of the left tibia and fibula were normal. He received oral antibiotics for presumed cellulitis...
October 8, 2018: Archives of Disease in Childhood. Education and Practice Edition
https://read.qxmd.com/read/29980754/attention-deficit-hyperactivity-disorder-is-associated-with-allergic-symptoms-and-low-levels-of-hemoglobin-and-serotonin
#37
JOURNAL ARTICLE
Liang-Jen Wang, Ya-Hui Yu, Ming-Ling Fu, Wen-Ting Yeh, Jung-Lung Hsu, Yao-Hsu Yang, Wei J Chen, Bor-Luen Chiang, Wen-Harn Pan
This study investigated whether common comorbidities or biochemical factors, such as allergic disease, anemia, inflammation, and neurotransmitters, are singly or additively associated with an increased risk of attention deficit-hyperactivity disorder (ADHD). We recruited 216 children diagnosed with ADHD and 216 age-, sex-, height-, weight-, and class-matched controls from 31 elementary schools in Taipei, Taiwan. The International Study of Asthma and Allergies in Childhood questionnaire was used to measure allergic symptoms...
July 6, 2018: Scientific Reports
https://read.qxmd.com/read/29696940/assessment-of-a-topical-product-based-on-polysulfated-galactosaminoglycan-as-an-adjuvant-in-the-treatment-of-acute-stp-and-stasis-dermo-hypodermitis
#38
JOURNAL ARTICLE
Angelo Santoliquido
BACKGROUND: Superficial thrombophlebitis (STP) is a relatively frequent pathology characterized by possible extension to the deep venous circulation, with notable local inflammatory reaction which is treated by subcutaneous administration of Fondaparinux. Stasis dermo-hypodermitis is characterized by cutaneous hyperpigmentation and eczema, treatment for which consists of the use of drugs targeting endothelial cells (mesoglycan, FFPM, sulodexide). In this study we evaluated the impact of local application of a mixture of semi-synthetic polysulfated galactosaminoglycans on the regression rate of STP and dermo-hypodermitis in patients treated with best medical therapy (BMT)...
August 2018: Minerva Medica
https://read.qxmd.com/read/29219814/cellulitis-current-insights-into-pathophysiology-and-clinical-management
#39
REVIEW
D R Cranendonk, A P M Lavrijsen, J M Prins, W J Wiersinga
Cellulitis is a bacterial skin and soft tissue infection which occurs when the physical skin barrier, the immune system and/or the circulatory system are impaired. Diabetes, obesity and old age are associated with defects in all of these areas and as a result are major predisposing factors for cellulitis. In this review, we summarise current insights into the pathophysiology of cellulitis and place the Dutch guidelines on the clinical management of cellulitis of the lower extremities in perspective. Recent evidence on diagnostic strategies is discussed, the importance of which is underscored by findings that venous insufficiency, eczema, deep vein thrombosis and gout are frequently mistaken for cellulitis...
November 2017: Netherlands Journal of Medicine
https://read.qxmd.com/read/29143961/upregulation-of-epidermal-gap-junctional-proteins-in-patients-with-venous-disease
#40
JOURNAL ARTICLE
M Kanapathy, R Simpson, L Madden, C Thrasivoulou, A Mosahebi, D L Becker, T Richards
BACKGROUND: Leg ulceration is a feared complication of venous insufficiency. It is not known whether varicose veins predispose skin to poor wound healing. The expression pattern of gap junctional protein connexin, a known marker of poor wound healing, was investigated across various stages of venous disease. METHODS: Patients undergoing intervention for varicose veins were assessed according to the Clinical Etiologic Anatomic Pathophysiologic (CEAP) classification of varicose veins...
January 2018: British Journal of Surgery
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