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https://www.readbyqxmd.com/read/29352512/trpv1-antagonists-that-cause-hypothermia-instead-of-hyperthermia-in-rodents-compounds-pharmacological-profiles-in-vivo-targets-thermoeffectors-recruited-and-implications-for-drug-development
#1
Andras Garami, Eszter Pakai, Heath A McDonald, Regina M Reilly, Arthur Gomtsyan, Joshua J Corrigan, Erika Pinter, Dawn X D Zhu, Sonya G Lehto, Narender R Gavva, Philip R Kym, Andrej A Romanovsky
AIM: Thermoregulatory side effects hinder the development of transient receptor potential vanilloid-1 (TRPV1) antagonists as new painkillers. While many antagonists cause hyperthermia, a well-studied effect, some cause hypothermia. The mechanisms of this hypothermia are unknown and were studied herein. METHODS: Two hypothermia-inducing TRPV1 antagonists, the newly synthesized A-1165901 and the known AMG7905, were used in physiological experiments in rats and mice...
January 20, 2018: Acta Physiologica
https://www.readbyqxmd.com/read/29352222/artificial-chameleon-skin-that-controls-spectral-radiation-development-of-chameleon-cool-coating-c3
#2
Hiroki Gonome, Masashi Nakamura, Junnosuke Okajima, Shigenao Maruyama
Chameleons have a diagnostic thermal protection that enables them to live under various conditions. Our developed special radiative control therefore is inspired by the chameleon thermal protection ability by imitating its two superposed layers as two pigment particles in one coating layer. One particle imitates a chameleon superficial surface for color control (visible light), and another particle imitates a deep surface to reflect solar irradiation, especially in the near-infrared region. Optical modeling allows us to optimally design the particle size and volume fraction...
January 19, 2018: Scientific Reports
https://www.readbyqxmd.com/read/29350880/temporal-and-spatial-quantification-of-pain-related-small-fiber-functionality-assessed-using-laser-speckle-contrast-analysis-lasca
#3
Isin Unal-Cevik
BACKGROUND: This study aimed to establish a practical method for assessing pain symptomatology and develop criteria for quantifying small fiber functions, using LASCA. METHODS: Axon flare responses, which reflect small fiber functions, were induced either by histamine or capsaicin applied to the volar surface of the skin of the left forearm. To inhibit small fiber function, local anesthetic cream was applied to the skin of right forearm. The effects on pain symptomatology (severity/timing) and axon flare responses (temporal/spatial characteristics) were measured using LASCA...
January 19, 2018: Pain Practice: the Official Journal of World Institute of Pain
https://www.readbyqxmd.com/read/29350788/reliability-and-validity-of-the-atopic-dermatitis-symptom-score
#4
Ji Young Lee, Minji Kim, Hea-Kyoung Yang, Hyun Mi Kim, Joongbum Cho, Young-Min Kim, In Seok Lim, Hae-Kwan Cheong, Hye Seung Kim, Insuk Sohn, Jihyun Kim, Kangmo Ahn
BACKGROUND: We have developed the Atopic Dermatitis Symptom Score (ADSS) by which patients or parents can easily assess and record AD symptoms on a daily basis in a smartphone application. The aim of the present study was to evaluate the reliability and validity of the ADSS. METHODS: We enrolled 307 children and adolescents with AD. Parents or caregivers were asked to record daily symptoms of the patients (itching, sleep disturbance, erythema, dryness, oozing, and oedema) using a scale of 0 to 4...
January 19, 2018: Pediatric Allergy and Immunology
https://www.readbyqxmd.com/read/29350451/morphological-specializations-of-the-epidermis-of-an-angler-catfish-chaca-chaca-siluriformes-chacidae-in-relation-to-its-ecological-niche-a-scanning-electron-microscopic-investigation
#5
Arup Mistri, Usha Kumari, Swati Mittal, Ajay Kumar Mittal
The present work was undertaken with the aim to deduce morphological adaptations in skin of an angler catfish Chaca chaca by means of scanning electron microscopy. The fish is nocturnal, bottom dwelling, sluggish, ambush predator, lives in sand, mud, or soft substrates often buried and camouflaged for protection and to feed. The surface of the epidermis is covered with polygonal epithelial cells, each having surface relief of microridges forming intricate patterns. In between epithelial cells irregularly distributed mucous cell openings, randomly distributed epidermal specialized structures, taste buds, and neuromasts are discernible...
January 19, 2018: Microscopy Research and Technique
https://www.readbyqxmd.com/read/29349894/assessment-of-the-potential-of-temporin-peptides-from-the-frog-rana-temporaria-ranidae-as-anti-diabetic-agents
#6
Vishal Musale, Bruno Casciaro, Maria Luisa Mangoni, Yasser H A Abdel-Wahab, Peter R Flatt, J Michael Conlon
Temporin A (FLPLIGRVLSGIL-NH2 ), temporin F (FLPLIGKVLSGIL-NH2 ), and temporin G (FFPVIGRILNGIL-NH2 ), first identified in skin secretions of the frog Rana temporaria, produced concentration-dependent stimulation of insulin release from BRIN-BD11 rat clonal β-cells at concentrations ≥1 nM, without cytotoxicity at concentrations up to 3 μM. Temporin A was the most effective. The mechanism of insulinotropic action did not involve an increase in intracellular Ca2+ concentrations. Temporins B, C, E, H, and K were either inactive or only weakly active...
January 19, 2018: Journal of Peptide Science: An Official Publication of the European Peptide Society
https://www.readbyqxmd.com/read/29349851/clinical-and-molecular-implications-of-structural-changes-to-desmosomes-and-corneodesmosomes
#7
REVIEW
Akemi Ishida-Yamamoto, Satomi Igawa, Mari Kishibe, Masaru Honma
Desmosomes provide the main intercellular adhesive properties between epidermal keratinocytes. Their distribution becomes uneven in severe dermatitis, multiple allergies and metabolic wasting syndrome due to desmoglein 1 deficiency and the loss of intercellular adhesion or acantholysis. When keratinocytes differentiate from granular cells into cornified cells, desmosomes are transformed into corneodesmosomes and can provide stronger intercellular adhesion. Degradation of corneodesmosomes is a tightly regulated process involving a number of proteases and their inhibitors...
January 19, 2018: Journal of Dermatology
https://www.readbyqxmd.com/read/29348630/expression-of-inflammasome-proteins-and-inflammasome-activation-occurs-in-human-but-not-in-murine-keratinocytes
#8
Jennifer Sand, Eric Haertel, Thomas Biedermann, Emmanuel Contassot, Ernst Reichmann, Lars E French, Sabine Werner, Hans-Dietmar Beer
Inflammasomes are multimeric protein complexes that assemble upon sensing of a variety of stress factors. Their formation results in caspase-1-mediated activation and secretion of the pro-inflammatory cytokines pro-interleukin(IL)-1β and -18, which induce an inflammatory response. Inflammation is supported by a lytic form of cell death, termed pyroptosis. Innate immune cells, such as macrophages or dendritic cells, express and activate inflammasomes. However, it has also been demonstrated that human primary keratinocytes activate different types of inflammasomes in vitro, for example, upon UVB irradiation or viral infection...
January 18, 2018: Cell Death & Disease
https://www.readbyqxmd.com/read/29346065/accuracy-of-principal-and-teacher-knowledge-of-school-district-policies-on-sun-protection-in-california-elementary-schools
#9
David B Buller, Kim D Reynolds, Julia Berteletti, Kim Massie, Jeff Ashley, Mary Klein Buller, Richard T Meenan
INTRODUCTION: Policy is a key aspect of school-based efforts to prevent skin cancer. We explored the extent and accuracy of knowledge among principals and teachers in California public school districts about the elements specified in their district's written sun safety policy. METHODS: The sample consisted of California public school districts that subscribed to the California School Boards Association, had an elementary school, adopted Board Policy 5141.7 for sun safety, and posted it online...
January 18, 2018: Preventing Chronic Disease
https://www.readbyqxmd.com/read/29346014/role-of-the-lymphatic-system-in-the-pathogenesis-of-hypertension-in-humans
#10
Angelika Chachaj, Bartosz Puła, Mariusz Chabowski, Jędrzej Grzegrzółka, Ewa Szahidewicz-Krupska, Maciej Karczewski, Dariusz Janczak, Piotr Dzięgiel, Marzenna Podhorska-Okołów, Grzegorz Mazur, Andrzej Gamian, Andrzej Szuba
BACKGROUND: Recent studies, mainly on animal models, have suggested that negatively charged glycosaminoglycans, macrophages, and lymph vessels in the skin interstitium may serve as extrarenal control of sodium balance and blood pressure. The aim of the study was to prove the hypothesis that skin interstitium has a role in the pathogenesis of hypertension in humans. METHODS AND RESULTS: We have examined skin biopsies in 91 patients from the department of surgery who had elective surgery with abdominal skin incision: 43 were hypertensive, 14 had resistant hypertension, and 34 with normal blood pressure as control group (median patients' age in these groups estimated accordingly 64 vs...
January 18, 2018: Lymphatic Research and Biology
https://www.readbyqxmd.com/read/29345319/endothelial-cells-enhance-adipose-mesenchymal-stromal-cell-mediated-matrix-contraction-via-alk-receptors-and-reduced-follistatin-potential-role-of-endothelial-cells-in-skin-fibrosis
#11
Hanneke N Monsuur, Lenie J van den Broek, Pieter Koolwijk, Frank B Niessen, Susan Gibbs
Abnormal cutaneous wound healing can lead to formation of fibrotic hypertrophic scars. Although several clinical risk factors have been described, the cross-talk between different cell types resulting in hypertrophic scar formation is still poorly understood. The aim of this in vitro study was to investigate whether endothelial cells (EC) may play a role in skin fibrosis, e.g. hypertrophic scar formation after full-thickness skin trauma. Using a collagen/elastin matrix, we developed an in vitro fibrosis model to study the interaction between EC and dermal fibroblasts or adipose tissue-derived mesenchymal stromal cells (ASC)...
January 18, 2018: Journal of Cellular Physiology
https://www.readbyqxmd.com/read/29345019/a-vascular-mechanism-to-explain-thermally-mediated-variations-in-deep-body-cooling-rates-during-the-immersion-of-profoundly-hyperthermic-individuals
#12
Joanne N Caldwell, Anne M J van den Heuvel, Pete Kerry, Mitchell J Clark, Gregory E Peoples, Nigel A S Taylor
Physiologically trivial time differences for cooling the intrathoracic viscera of hyperthermic individuals have been reported between cold- and temperate-water immersion treatments. One explanation for that observation is reduced convective heat delivery to the skin during cold immersion, and this experiment was designed to test both the validity of that observation, and its underlying hypothesis. Eight healthy males participated in four head-out, water immersions: two when normothermic, and two following exercise-induced, moderate-profound hyperthermia...
January 18, 2018: Experimental Physiology
https://www.readbyqxmd.com/read/29345004/epidermal-permeability-barrier-function-and-sphingolipid-content-in-the-skin-of-sphingomyelin-synthase-2-deficient-mice
#13
Koji Nomoto, Yurina Itaya, Ken Watanabe, Tadashi Yamashita, Toshiro Okazaki, Yoshihiro Tokudome
BACKGROUND: Sphingomyelin synthase (SMS) is an enzyme that generates sphingomyelin (SM) from ceramide (CER) and phosphatidylcholine. SM in the epidermis is a precursor of CER, an important lipid for epidermal permeability barrier function. However, the physiological role of SMS in skin is unclear. OBJECTIVES: To uncover the function of SMS in skin, we investigated sphingolipid metabolism enzyme activity in skin, SM content in the epidermis, CER content in the stratum corneum (SC) and transepidermal water loss (TEWL) as an indicator of barrier function in SMS2-knockout (KO) mice...
January 17, 2018: Experimental Dermatology
https://www.readbyqxmd.com/read/29344961/in-vivo-evaluation-of-some-biophysical-parameters-of-the-facial-skin-of-indian-subjects-living-in-mumbai-part-ii-variability-with-age-and-gender
#14
Loïc Colomb, Frederic Flament, Anupama Wagle, Youssef Idelcaid, Divya Agrawal
BACKGROUND: A previously published work explored the diversity of some biophysical parameters (colour, elasticity, sebum production, skin micro relief….) of the skin of 1204 Indian women, differently aged, living in 4 Indian cities (Chennai, Delhi, Kolkata, Mumbai). The present work aimed at completing such research by focusing on possible gender-related differences in the same skin parameters, between Indian men and women living in the same Indian city (Mumbai). METHODS: 297 Indian men, differently aged (18-70y) were recruited in Mumbai, completing the panel of 303 women who were previously recruited in this same city...
January 17, 2018: International Journal of Cosmetic Science
https://www.readbyqxmd.com/read/29343198/localization-of-felis-catus-papillomavirus-type-2-e6-and-e7-rna-in-feline-cutaneous-squamous-cell-carcinoma
#15
Nathan Hoggard, John S Munday, Jennifer Luff
Findings from polymerase chain reaction-based methods have suggested a role of Felis catus papillomavirus 2 (FcaPV-2) in the development of feline cutaneous squamous cell carcinoma (SCC). However, because polymerase chain reaction cannot localize deoxyribonucleic acid or ribonucleic acid within the lesion, it is difficult to differentiate a coincidental FcaPV-2 infection and a causative association. Given that a key event in the pathogenesis of human papillomavirus-induced cancer is the expression of viral E6 and E7 oncogenes, localization of FcaPV-2 E6 and E7 transcription within neoplastic cells in feline SCCs would support a causative role for this papillomavirus...
January 1, 2018: Veterinary Pathology
https://www.readbyqxmd.com/read/29342504/symmetric-polyarthralgias-and-cutaneous-papulonodules-in-a-56-year-old-woman
#16
Sean B Singer, Cristina Thomas, Cecilia Lezcano, Mark Robbins, Amparo Gordian, Sarita Nori, Scott R Granter, Joseph F Merola, John T O'Malley
A 56-year-old female with no history of arthritis presented with a two month history of a diffuse, pruritic, painful papulonodular skin eruption, diffuse myalgias, and symmetric polyarthritis of the hands, shoulders, knees, and ankles. This article is protected by copyright. All rights reserved.
January 17, 2018: Arthritis Care & Research
https://www.readbyqxmd.com/read/29342499/efficacy-and-safety-of-cyclophosphamide-treatment-in-severe-juvenile-dermatomyositis-shown-by-marginal-structural-modelling
#17
Claire T Deakin, Raquel Campanilho-Marques, Stefania Simou, Elena Moraitis, Lucy R Wedderburn, Eleanor Pullenayegum, Clarissa A Pilkington
OBJECTIVE: In patients with severe or refractory juvenile dermatomyositis (JDM), second-line treatments may be required. Cyclophosphamide (CYC) is used to treat some connective tissue diseases, but evidence of efficacy in JDM is limited. This study aimed to describe clinical improvement in JDM patients treated with CYC and model efficacy of CYC compared to patients not treated with CYC. METHODS: Clinical data on skin, global and muscle disease were analyzed from patients recruited to the Juvenile Dermatomyositis Cohort and Biomarker Study...
January 17, 2018: Arthritis & Rheumatology
https://www.readbyqxmd.com/read/29342313/collagen-xii-myopathy-with-rectus-femoris-atrophy-and-collagen-xii-retention-in-fibroblasts
#18
Nanna Witting, Thomas Krag, Ulla Werlauff, Morten Duno, Sofie Thuroe Oestergaard, Julia Rebecka Dahlqvist, John Vissing
INTRODUCTION: Mutation in the collagen XII gene (COL12A1) was recently reported to induce Bethlem myopathy. We describe a family affected by collagen XII-related myopathy in 3 generations. METHODS: Systematic interview, clinical examination, skin biopsies and MRI muscle. RESULTS: The phenotype was characterized by neonatal hypotonia, contractures and delayed motor development followed by resolution of contractures and a motor performance limited by reduced endurance...
January 17, 2018: Muscle & Nerve
https://www.readbyqxmd.com/read/29341894/protective-effects-of-antioxidin-rl-from-odorrana-livida-against-ultraviolet-b-irradiated-skin-photoaging
#19
Di Qin, Wen-Hui Lee, Zhiqin Gao, Weifen Zhang, Meiyu Peng, Tongyi Sun, Yuanyuan Gao
The unavoidable daily exposure of the skin to ultraviolet (UV) B radiation is proven to have deleterious effects. The action mechanism of antioxidin-RL, an antioxidant peptide purified from skin secretions of frog Odorrana livida with amino acid sequence of AMRLTYNRPCIYAT, is well characterized by NMR titration and mutation based on ABTS+ scavenging activities. In order to explore the protective effects of antioxidin-RL against UVB-irradiated skin photoaging, cell uptake assay was used to detect the location of antioxidin-RL molecules serving various biological functions in the cells...
January 13, 2018: Peptides
https://www.readbyqxmd.com/read/29341355/reflectance-confocal-microscopy-and-optical-coherence-tomography-for-the-diagnosis-of-bullous-pemphigoid-and-pemphigus-and-surrounding-sub-clinical-lesions
#20
V D Mandel, E Cinotti, E Benati, B Labeille, S Ciardo, C Vaschieri, F Cambazard, J L Perrot, G Pellacani
BACKGROUND: Diagnosis of bullous pemphigoid (BP) and pemphigus is based on clinical features, histology, immunofluorescence and laboratory data. OBJECTIVES: To evaluate features of BP and pemphigus at reflectance confocal microscopy (RCM) and optical coherence tomography (OCT) in order to provide a rapid non-invasive bed-side diagnosis. Secondary objective was to evaluate the detectability of clinically non-visible lesions. METHODS: This was an observational, retrospective, multicentre study in which patients with suspicious lesions for BP or pemphigus underwent clinical assessment, RCM, OCT, blood tests and skin biopsy for histological and direct immunofluorescence examinations from January 2014 to December 2015...
January 16, 2018: Journal of the European Academy of Dermatology and Venereology: JEADV
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