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https://www.readbyqxmd.com/read/27914166/trauma-related-dissociation-psychological-features-and-psychophysiological-responses-to-script-driven-imagery-in-borderline-personality-disorder
#1
Dana Bichescu-Burian, Jürgen Steyer, Tilman Steinert, Benjamin Grieb, Stefan Tschöke
Defense reactions to threatening situations are vital adaptations to stress that protect organisms from injury and ensure survival. We retrospectively investigated the role of peritraumatic dissociation (PD) in the occurrence of severe psychopathology and dissociative patterns of reactions in borderline personality disorder (BPD). We recruited 28 patients with a clinical diagnosis of BPD and 15 healthy controls. The BPD group was divided according to the level of PD (low vs. high): BPD and PD (n = 15) and BPD only (n = 13)...
December 3, 2016: Psychophysiology
https://www.readbyqxmd.com/read/27907267/mitogenic-action-of-hypoxia-upon-cutaneous-neuroepithelial-cells-in-developing-zebrafish
#2
Benjamin W Dean, Thalia J Rashid, Michael G Jonz
In zebrafish, cutaneous neuroepithelial cells (NECs) contain serotonin (5-HT) and are believed to initiate physiological and behavioral responses to hypoxia during embryonic and early larval development, when mature gills and O2 chemoreceptors are not yet present. The number of skin NECs rapidly declines as embryos develop into larvae, but acclimation to hypoxia leads to retention of a greater number of these cells. We hypothesized that reduction of the partial pressure of oxygen (PO2 ) in water would stimulate mitosis in cutaneous NECs in zebrafish...
December 1, 2016: Developmental Neurobiology
https://www.readbyqxmd.com/read/27907090/forkhead-box-c1-regulates-human-primary-keratinocyte-terminal-differentiation
#3
Lianghua Bin, Liehua Deng, Hengwen Yang, Leqing Zhu, Xiao Wang, Michael G Edwards, Brittany Richers, Donald Y M Leung
The epidermis serves as a critical protective barrier between the internal and external environment of the human body. Its remarkable barrier function is established through the keratinocyte (KC) terminal differentiation program. The transcription factors specifically regulating terminal differentiation remain largely unknown. Using a RNA-sequencing (RNA-seq) profiling approach, we found that forkhead box c 1 (FOXC1) was significantly up-regulated in human normal primary KC during the course of differentiation...
2016: PloS One
https://www.readbyqxmd.com/read/27904874/imaging-of-accidental-contamination-by-fluorine-18-solution-a-quick-troubleshooting-procedure
#4
Kalevi Kairemo, Aki Kangasmäki
To the best of our knowledge, imaging of accidental exposure to radioactive fluorine-18 (F-18) due to liquid spill has not been described earlier in the scientific literature. The short half-life of F-18 (t½=110 min), current radiation safety requirements, and Good Manufacturing Practice (GMP) regulations on radiopharmaceuticals have restrained the occurrence of these incidents. The possibility of investigating this type of incidents by gamma and positron imaging is also quite limited. Additionally, a quick and precise analysis of radiochemical contamination is cumbersome and sometimes challenging if the spills of radioactive materials are low in activity...
2016: Asia Oceania Journal of Nuclear Medicine & Biology
https://www.readbyqxmd.com/read/27904274/pretreatment-of-ferulic-acid-protects-human-dermal-fibroblasts-against-ultraviolet-a-irradiation
#5
Hyung Jin Hahn, Ki Bbeum Kim, Seunghee Bae, Byung Gon Choi, Sungkwan An, Kyu Joong Ahn, Su Young Kim
BACKGROUND: Approximately 90%~99% of ultraviolet A (UVA) ray reaches the Earth's surface. The deeply penetrating UVA rays induce the formation of reactive oxygen species (ROS), which results in oxidative stress such as photoproducts, senescence, and cell death. Thus, UVA is considered a primary factor that promotes skin aging. OBJECTIVE: Researchers investigated whether pretreatment with ferulic acid protects human dermal fibroblasts (HDFs) against UVA-induced cell damages...
December 2016: Annals of Dermatology
https://www.readbyqxmd.com/read/27903435/lack-of-effect-of-selected-sunscreens-applied-on-ex-vivo-human-skin-for-5-methyl-aminolevulinic-acid-penetration-and-protoporphyrin-ix-photoactivation
#6
Hanan Osman-Ponchet, Karine Sevin, Alexandre Gaborit, Magali Kouidhi, Johanna Hanaizi, Pierre Comby, Bernard Ruty, Guy Bouvier
BACKGROUND: Photodynamic therapy (PDT) is a successful treatment for non-melanoma skin cancers. Methyl-aminolevulinate (MAL) is metabolized to protoporphyrin IX (PpIX) which accumulates in the skin lesion and which generates a painful photochemical toxic reaction upon red light exposure. PDT using daylight (DL) exposure is now used to reduce pain and subjects are advised to protect the areas with sunscreen. This work investigated the effect of sunscreen on MAL penetration and PpIX photoactivation in ex vivo human skin...
November 26, 2016: Photodiagnosis and Photodynamic Therapy
https://www.readbyqxmd.com/read/27900769/influence-of-menstrual-phase-and-arid-vs-humid-heat-stress-on-autonomic-and-behavioural-thermoregulation-during-exercise-in-trained-but-unacclimated-women
#7
Tze-Huan Lei, Stephen R Stannard, Blake G Perry, Zachary J Schlader, James D Cotter, Toby Mündel
We studied thermoregulatory responses of ten well-trained (VO2 max, 57 (7) mL min(-1) kg(-1) ) eumenorrheic women exercising in dry and humid heat, across their menstrual cycle. They completed four trials, each of resting and cycling at fixed intensities (125 and 150 W), to assess autonomic regulation, then self-paced intensity (30-min work trial), to assess behavioural regulation. Trials were in early-follicular (EF) and mid-luteal (ML) phases in dry (DRY) and humid (HUM) heat matched for wet bulb globe temperature (WBGT, 27°C)...
November 29, 2016: Journal of Physiology
https://www.readbyqxmd.com/read/27896875/disseminated-cobblestone-like-skin-lumps-in-a-newborn
#8
Z X Ren, H Q Jiang, L X Zhang, Q D Deng, J Y Zhang, X P Mu, J Yang
An newborn boy showed multiple skin lumps at birth. On examination, there were disseminated red cobblestone-like skin neoplasms, 5-30mm in diameter with hard serosanguineous crust, some were with scabs, over the scalp, face, trunk and extremities (Fig. 1A,B). The liver was 3 cm palpable below the costal margin. He was active and stable. The mother' prenatal investigation on antibodies of rubella, herpes simplex virus (HSV) and hepatitis B surface antigen were positive. The baby's antibodies for HAV, HBV, HCV, rubella, HSV, HIV and syphilis were negative...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27896872/sunbed-use-among-portuguese-beach-goers-a-crave-group-while-wainting-sunbeds-to-be-abolished
#9
A F Duarte, J N Maia Silva, A Costa Pereira, E Nagore, A Picoto, O Correia
Although sunbed use is considered a complete carcinogen for skin cancer, over the past decades exposure to indoor tanning is becoming more popular.(1, 2) The risk appears to be stronger for young women, initial use at an early age (less than 35 years) and higher number of sunbed sessions. (3, 4) With this study we aim to better understand the features of sunbed users in Portuguese beach goers, a group at high risk for skin cancer. This article is protected by copyright. All rights reserved.
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27896871/the-old-reliables-outperform-new-media-in-social-marketing-of-euromelanoma-in-ireland
#10
L Roche, C C Foley, S McCarthy, M Murphy
Euromelanoma is a pan-European prevention campaign against skin cancer and promotes a walk-in screening day in May of each year. The screening day serves to highlight awareness of skin cancer amongst the general public and to encourage self-checks for new or changing lesions. The South Infirmary Victoria University Hospital (SIVUH) provides regional dermatology and skin cancer services for the Cork/Kerry region in Ireland and held a Euromelanoma Screening day in May 2014 and 2015. This article is protected by copyright...
November 29, 2016: Journal of the European Academy of Dermatology and Venereology: JEADV
https://www.readbyqxmd.com/read/27896827/leaping-through-the-looking-glass-secondary-analysis-of-the-effect-of-skin-test-size-and-age-of-introduction-on-peanut-tolerance-after-early-peanut-introduction
#11
Matthew Greenhawt, David Fleischer, Edmond S Chan, Carina Venter, David Stukus, Ruchi Gupta, Jonathan Spergel
BACKGROUND: In the Learning Early About Peanut Allergy (LEAP) study, early peanut introduction in high-risk 4-11 month olds was associated with a significantly decreased risk of developing peanut allergy. However, the influences of key baseline high-risk factors on peanut tolerance are poorly understood. METHODS: Secondary analysis was conducted on the publically available LEAP dataset, exploring relationships between peanut tolerance, baseline peanut/egg sensitization, eczema severity/duration, age of introduction, gender, and race...
November 29, 2016: Allergy
https://www.readbyqxmd.com/read/27896634/th9-cells-in-skin-disorders
#12
REVIEW
Rachael A Clark, Christoph Schlapbach
Interleukin 9 secreting TH9 cells have been proposed as the latest addition to the family of T helper cell subsets. While a growing body of evidence from animal models points to important roles for these cells in allergic inflammation of the lung, autoinflammation of the gastrointestinal tract, and tumor immunity, their role in skin immunity and skin immunopathology remains poorly defined. Interestingly, studies of T helper cells from healthy humans suggest that TH9 cells are predominantly skin-homing and skin-resident and that they are involved in protection against extracellular pathogens...
November 28, 2016: Seminars in Immunopathology
https://www.readbyqxmd.com/read/27895903/deliberate-exposure-of-humans-to-chlorine-the-aftermath-of-ebola-in-west-africa
#13
Shaheen Mehtar, Andre N H Bulabula, Haurace Nyandemoh, Steve Jambawai
BACKGROUND: During the recent Ebola outbreak, spraying of the environment and humans, including healthcare workers, with chlorine was wide spread in affected African countries; adverse clinical effects are reported here. METHODS: A cross sectional survey by interview of 1550 volunteers consisting of 500 healthcare workers (HCW), 550 Ebola survivors (EVD) and 500 quarantined asymptomatic Ebola contacts (NEVD) was conducted. Demographics, frequency of exposure to chlorine, clinical condition after chlorine exposure particularly eye, respiratory and skin conditions were noted...
2016: Antimicrobial Resistance and Infection Control
https://www.readbyqxmd.com/read/27895891/gene-specific-sex-effects-on-eosinophil-infiltration-in-leishmaniasis
#14
Martina Slapničková, Valeriya Volkova, Marie Čepičková, Tatyana Kobets, Matyáš Šíma, Milena Svobodová, Peter Demant, Marie Lipoldová
BACKGROUND: Sex influences susceptibility to many infectious diseases, including some manifestations of leishmaniasis. The disease is caused by parasites that enter to the skin and can spread to the lymph nodes, spleen, liver, bone marrow, and sometimes lungs. Parasites induce host defenses including cell infiltration, leading to protective or ineffective inflammation. These responses are often influenced by host genotype and sex. We analyzed the role of sex in the impact of specific gene loci on eosinophil infiltration and its functional relevance...
2016: Biology of Sex Differences
https://www.readbyqxmd.com/read/27894934/mir-142-is-required-for-staphylococcus-aureus-clearance-at-skin-wound-sites-via-small-gtpase-mediated-regulation-of-the-neutrophil-actin-cytoskeleton
#15
Katsuya Tanaka, Sang Eun Kim, Hiroki Yano, Gaku Matsumoto, Ryoma Ohuchida, Yuhoko Ishikura, Masatake Araki, Kimi Araki, Seongjoon Park, Toshimitsu Komatsu, Hiroko Hayashi, Kazuya Ikematsu, Katsumi Tanaka, Akiyoshi Hirano, Paul Martin, Isao Shimokawa, Ryoichi Mori
MicroRNAs (miRNAs) are small noncoding RNAs that regulate protein translation by binding to complementary target mRNAs. We previously identified two mature members of the miR-142 family, miR-142-5p and miR-142-3p, as inflammation-related miRNAs with potential roles in wound healing. Here, we demonstrated that these two miRNAs are prominently expressed in wound-infiltrated neutrophils and macrophages and play central roles in wound healing. We generated miR-142(-/-) mice using the exchangeable gene-trap method and showed that healing of Staphylococcus aureus-infected skin wounds was significantly delayed in miR-142(-/-) mice compared with that in wild-type mice...
November 25, 2016: Journal of Investigative Dermatology
https://www.readbyqxmd.com/read/27893465/accelerated-resolution-of-inflammation-underlies-sex-differences-in-inflammatory-responses-in-humans
#16
Krishnaraj S Rathod, Vikas Kapil, Shanti Velmurugan, Rayomand S Khambata, Umme Siddique, Saima Khan, Sven Van Eijl, Lorna C Gee, Jascharanpreet Bansal, Kavi Pitrola, Christopher Shaw, Fulvio D'Acquisto, Romain A Colas, Federica Marelli-Berg, Jesmond Dalli, Amrita Ahluwalia
BACKGROUND: Cardiovascular disease occurs at lower incidence in premenopausal females compared with age-matched males. This variation may be linked to sex differences in inflammation. We prospectively investigated whether inflammation and components of the inflammatory response are altered in females compared with males. METHODS: We performed 2 clinical studies in healthy volunteers. In 12 men and 12 women, we assessed systemic inflammatory markers and vascular function using brachial artery flow-mediated dilation (FMD)...
November 28, 2016: Journal of Clinical Investigation
https://www.readbyqxmd.com/read/27892645/endothelial-cell-derived-endothelin-1-is-involved-in-abnormal-scar-formation-by-dermal-fibroblasts-through-rhoa-rho-kinase-pathway
#17
Koichiro Kiya, Tateki Kubo, Kenichiro Kawai, Shinsuke Matsuzaki, Rieko Muramatsu, Daisuke Maeda, Toshihiro Fujiwara, Akimitsu Nishibayashi, Shigeyuki Kanazawa, Kenji Yano, Genki Amano, Taiichi Katayama, Ko Hosokawa
Hypertrophic scars and keloids are characterized by excessive dermal deposition of extracellular matrix due to fibroblast-to-myofibroblast differentiation. Endothelin-1 (ET-1) is primarily produced by vascular endothelial cells, and plays multiple roles in the wound-healing response and organ fibrogenesis. In this study, we investigated the pathophysiological significance of ET-1 and involvement of RhoA, a member of the Rho GTPases, in hypertrophic scar/keloid formation. We found that ET-1 expression on dermal microvascular endothelial cells (ECs) in hypertrophic scars and keloids was higher than that in normal skin and mature scars...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27892610/beside-to-bench-jak-inhibitor-ruxolitinib-inhibits-the-expression-of-cytokines-characteristic-of-cutaneous-lupus-erythematosus
#18
Anna Sophie Klaeschen, Dominik Wolf, Peter Brossart, Thomas Bieber, Joerg Wenzel
This study was stimulated by the clinical observation of a rapid response of a chilblain lupus patient to treatment with JAK1/2-kinase inhibitor ruxolitinib. We investigated the in-vivo expression of phospho-JAK2 in CLE skin samples as well as the immunomodulatory in-vitro effect of ruxolitinib in cultured immortalized keratinocytes and in a 3D human epidermis model (epiCS). Our results demonstrate that ruxolitinib significantly decreases the production of CLE-typical cytokines (CXCL10, CXCL9, MxA) and might be a promising drug for future clinical studies in patients with CLE and related autoimmune skin diseases...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27892609/bad-air-gets-under-your-skin
#19
Roxanna Koohgoli, Laura Hudson, Khimara Naidoo, Simon Wilkinson, Bhaven Chavan, Mark A Birch-Machin
Air pollution is increasing beyond previous estimates and is viewed as the world's largest environmental health risk factor. Numerous clinical and epidemiological studies have highlighted the adverse effects of environmental pollutants on health. Although there is comparatively less research investigating the cutaneous effects of ambient pollution, there is growing recognition of the adverse effects on skin. In this article we provide an overview of the nature of environmental pollution and highlight the current evidence detailing the effects on cutaneous health...
November 28, 2016: Experimental Dermatology
https://www.readbyqxmd.com/read/27892608/an-advanced-mouse-model-for-human-skin-wound-healing
#20
Jie Wen, Xiangyong Li, Xue Leng, Xin Xu, Xunwei Wu
Here we report a model for studying wound repair based on skin regenerated from human tissue culture-expanded cells. The reconstituted skin (hRSK) responds to injury similar to that of intact human skin, and its constituent cells contribute to the healing process. As we have demonstrrated that hRSK composed of GFP-labelled cells also heals "normally", we believe this model will be useful in analyzing the wound repair process using genetically modified human cells. This article is protected by copyright. All rights reserved...
November 28, 2016: Experimental Dermatology
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