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https://www.readbyqxmd.com/read/29169002/skin-cancer-awareness-amongst-irish-golfers
#1
S McCarthy, L Paul, M O'Connell
Aim The aim of this study was to assess skin cancer awareness and identify the UV protective measures used by golfers within the Munster region of Ireland. Methods Subjects were recruited from throughout the Munster region at a regional competition, and at three other local golf clubs and "pro" shops. Participants filled out a short anonymous validated questionnaire when collecting their score cards7. Results One hundred and sixty-three golfers completed the questionnaire with a mean age of 65.6 years. 137 (84%) were male and 26 (16%) were female...
August 12, 2017: Irish Medical Journal
https://www.readbyqxmd.com/read/29168893/oral-tolerance-modulates-the-skin-transcriptome-in-mice-with-induced-atopic-dermatitis
#2
Jin Ok Baek, Jong Rok Lee, Joo Young Roh, YunJae Jung
Defective gut immune reactions have been implicated in the development of atopic dermatitis (AD), whereas oral tolerance (OT), i.e., the immune unresponsiveness induced by oral antigen administration, protects mice against AD. To investigate this protective role of OT, the transcriptomic profiles of skin were obtained by RNA sequencing from mice that were epicutaneously sensitized, orally tolerized prior to epicutaneous sensitization, or neither (control). OT inhibited the upregulation of keratin- and allergic inflammation-associated genes that occurred in the epicutaneously sensitized group...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29168570/specific-immunotherapy-in-lar-a-randomized-double-blind-placebo-controlled-trial-with-phleum-pratense-subcutaneous-allergen-immunotherapy
#3
Carmen Rondón, Natalia Blanca-López, Paloma Campo, Cristobalina Mayorga, Raquel Jurado-Escobar, Maria J Torres, Gabriela Canto, Miguel Blanca
BACKGROUND: Allergen immunotherapy has been shown to be an effective treatment for local allergic rhinitis (LAR) to house dust mites. Studies with pollen allergen immunotherapy are limited to observational studies. The aim of this study was to evaluate the clinical efficacy and safety of Phleum pratense subcutaneous immunotherapy (Phl-SCIT) in LAR. METHODS: In a randomized double-blind placebo-controlled study, 56 patients with moderate-severe LAR to grass pollen received Phl-SCIT with a depigmented-polymerized pollen vaccine or placebo for the first year, and Phl-SCIT the second one...
November 23, 2017: Allergy
https://www.readbyqxmd.com/read/29168446/a-randomized-trial-of-two-cover-gowns-comparing-contamination-of-healthcare-personnel-during-removal-of-personal-protective-equipment
#4
Thriveen S C Mana, Myreen E Tomas, Jennifer L Cadnum, Annette L Jencson, Christina T Piedrahita, Curtis J Donskey
In a randomized trial, a gown designed to allow easy removal at the neck and with increased skin coverage and snugness of fit at the wrist significantly reduced contamination of personnel during personal protective equipment (PPE) removal. Our results suggest that simple modifications of PPE can reduce contamination of personnel. Infect Control Hosp Epidemiol 2017;1-4.
November 23, 2017: Infection Control and Hospital Epidemiology
https://www.readbyqxmd.com/read/29168329/percutaneous-bone-anchored-hearing-system-implant-survival-after-550-primary-implant-surgeries
#5
T G A Calon, J van Tongeren, A M E Heuft, J W Brunings, D Bollen, J R Hof, R J Stokroos
The Bone Anchored Hearing System (BAHS) has become an established option for rehabilitation of several type of hearing impairment such as conductive hearing loss, mixed hearing loss and single sided deafness (1) . Overall good outcomes have been reported. Nevertheless, complications such as inflammation of the skin around the percutaneous abutment, pain and implant loss are related to BAHS (2) . This article is protected by copyright. All rights reserved.
November 23, 2017: Clinical Otolaryngology
https://www.readbyqxmd.com/read/29168291/the-col5a3-and-mmp9-genes-interact-in-eczema-susceptibility
#6
Patricia Margaritte-Jeannin, Marie-Claude Babron, Catherine Laprise, Nolwenn Lavielle, Chloé Sarnowski, Myriam Brossard, Miriam Moffatt, Valérie Gagné-Ouellet, Adrien Etcheto, Mark Lathrop, Jocelyne Just, William O Cookson, Emmanuelle Bouzigon, Florence Demenais, Marie-Hélène Dizier
BACKGROUND: Genetic studies of eczema have identified many genes, which explain only 14% of the heritability. Missing heritability may be partly due to ignored Gene-Gene (G-G) interactions. OBJECTIVE: Our aim was to detect new interacting genes involved in eczema. METHODS: The search for G-G interaction in eczema was conducted using a two-step approach, which included as a first step, a biological selection of genes, which are involved either in the skin or epidermis development or in the collagen metabolism, and as a second-step, an interaction analysis of the selected genes...
November 23, 2017: Clinical and Experimental Allergy: Journal of the British Society for Allergy and Clinical Immunology
https://www.readbyqxmd.com/read/29168250/the-effect-of-skin-to-skin-care-on-cerebral-oxygenation-during-nasogastric-feeding-of-preterm-infants
#7
A Marulli, C O F Kamlin, J A Dawson, S M Donath, P G Davis, L Lorenz
AIM: To describe cerebral oxygenation during gavage feeding of preterm infants during incubator and skin-to-skin care. METHODS: Further analysis of data from two crossover studies comparing cerebral oxygenation, heart rate and oxygen saturation during skin-to-skin care with incubator care. Data were analysed in three epochs; 10 mins pre-feed, during-feed, and 10 mins post-feed. Measurements from infants fed during incubator care were compared with those obtained during skin-to-skin care...
November 23, 2017: Acta Paediatrica
https://www.readbyqxmd.com/read/29168183/effectiveness-of-gastrostomy-for-improving-nutritional-status-and-quality-of-life-in-patients-with-epidermolysis-bullosa-a-systematic-review
#8
REVIEW
A P C Zidorio, E S Dutra, L C G Castro, K M B Carvalho
Inherited epidermolysis bullosa (EB) is a group of rare genetic disorders clinically characterized by a wide range of skin and mucosal blistering after minor trauma(1) . This condition is caused by mutations on genes coding for structural proteins of the skin and affects both genders from all ethnic groups, and its estimated prevalence is about 500,000 cases worldwide(2) . This article is protected by copyright. All rights reserved.
November 23, 2017: British Journal of Dermatology
https://www.readbyqxmd.com/read/29167824/protein-activation-mapping-of-human-sun-protected-epidermis-after-an-acute-dose-of-erythemic-solar-simulated-light
#9
Janine G Einspahr, Clara Curiel-Lewandrowski, Valerie S Calvert, Steven P Stratton, David S Alberts, James Warneke, Chengcheng Hu, Kathylynn Saboda, Elisabeth L Wagener, Sally Dickinson, Zigang Dong, Ann M Bode, Emanuel F PetricoinIII
Ultraviolet radiation is an important etiologic factor in skin cancer and a better understanding of how solar stimulated light (SSL) affects signal transduction pathways in human skin which is needed in further understanding activated networks that could be targeted for skin cancer prevention. We utilized Reverse Phase Protein Microarray Analysis (RPPA), a powerful technology that allows for broad-scale and quantitative measurement of the activation/phosphorylation state of hundreds of key signaling proteins and protein pathways in sun-protected skin after an acute dose of two minimal erythema dose (MED) of SSL...
2017: NPJ Precis Oncol
https://www.readbyqxmd.com/read/29167671/immune-checkpoint-targets-for-host-directed-therapy-to-prevent-and-treat-leishmaniasis
#10
REVIEW
Rajiv Kumar, Shashi Bhushan Chauhan, Susanna S Ng, Shyam Sundar, Christian R Engwerda
Leishmaniasis encompasses a group of diseases caused by protozoan parasites belonging to the genus Leishmania. These diseases range from life threatening visceral forms to self-healing cutaneous lesions, and each disease manifestations can progress to complications involving dissemination of parasites to skin or mucosal tissue. A feature of leishmaniasis is the key role host immune responses play in disease outcome. T cells are critical for controlling parasite growth. However, they can also contribute to disease onset and progression...
2017: Frontiers in Immunology
https://www.readbyqxmd.com/read/29166701/when-is-protection-from-impact-needed-for-the-face-as-well-as-the-eyes-in-occupational-environments
#11
Stephen J Dain, Rose Huang, Aimee Tiao, B Ralph Chou
BACKGROUND: The most commonly identified reason for requiring or using occupational eye and face protection is for protection against flying objects. Standards vary on what risk may require protection of the eyes alone and what requires protection for the whole face. Information on the minimum energy transfer for face damage to occur is not well-established. METHODS: The heads of pigs were used as the common model for human skin. A 6 mm steel ball projected at velocities between 45 and 135 m/s was directed at the face area...
November 22, 2017: Clinical & Experimental Optometry: Journal of the Australian Optometrical Association
https://www.readbyqxmd.com/read/29165634/the-icru-proposal-for-new-operational-quantities-for-external-radiation
#12
T Otto, N E Hertel, D T Bartlett, R Behrens, J-M Bordy, G Dietze, A Endo, G Gualdrini, M Pelliccioni
Report Committee 26 of the ICRU proposes a set of operational quantities for radiation protection for external radiation, directly based on effective dose and for an extended range of particles and energies. It is accompanied by quantities for estimating deterministic effects to the eye lens and the local skin. The operational quantities are designed to overcome the conceptual and technical shortcomings of those presently in use. This paper describes the proposed operational quantities, and highlights the improvements with respect to the present, legal monitoring quantities...
November 18, 2017: Radiation Protection Dosimetry
https://www.readbyqxmd.com/read/29164778/open-label-study-assessing-the-efficacy-and-tolerability-of-topical-skincare-and-sun-protection-products-following-intense-pulsed-light-treatment
#13
Isabela T Jones, Isabella Guiha, Sabrina G Fabi
BACKGROUND: The visible signs of photodamage can be improved by intense pulsed light (IPL). Active ingredients in cosmeceuticals also have effects on skin quality and pigmentation, and can camouflage post-treatment side effects. Combination therapies utilizing different treatment modalities have been shown to optimize clinical outcomes for skin rejuvenation and patient satisfaction. AIM: To evaluate the efficacy of a combination of IPL with a daily topical skincare and sunscreen regimen for the treatment of facial photodamage and for the improvement of IPL treatment tolerability...
November 21, 2017: Journal of Cosmetic Dermatology
https://www.readbyqxmd.com/read/29164629/impact-of-ultraviolet-radiation-on-expression-of-transforming-growth-factor-beta-smad2-metalloproteinases-cathepsin-k-and-progerin
#14
Magdalena Ciążyńska, Igor A Bednarski, Karolina Wódz, Joanna Narbutt, Michał Sobjanek, Anna Woźniacka, Aleksandra Lesiak
Ultraviolet radiation (UVR) is one of the most important environmental factors involved in photoaging. Exposure to UVR leads to dysregulation of expression of cell-cycle-related proteins which play key role in skin photodegradation that pretends to develop carcinogenesis. This study examines the role of various UVB doses on the expression of transforming growth factor beta (TGF-β), Smad2, cathepsin K, progerin and matrix metalloproteinases (MMPs)-1,-3,-8,-9. A group consisting of 63 healthy individuals underwent one of the following treatments: 1) whole-body exposed to UVB irradiation on each of 10 consecutive days with 0...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29164624/suppression-of-uvb-mediated-matrix-metalloproteinase-generation-by-sorbus-commixta-twig-extract-in-human-dermal-fibroblasts
#15
Song Hua Xuan, Young Min Park, So Hyun Park, Hyo Jin Jeong, Soo Nam Park
Sorbus commixta is a traditional oriental medicinal plant that grows in East Asian countries such as Korea, Japan, and China. The twig of S. commixta has been considered valuable for centuries to treat diseases including asthma, cough, and other bronchial disorders. However, the effect of S. commixta twig extract on human skin has not been investigated well. The present study aimed at assessing the anti-photoaging effect of S. commixta twig ethanol extract (STE) on ultraviolet B (UVB)-induced matrix metalloproteinase (MMP) levels and its underlying mechanism in human dermal fibroblasts...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29164618/analysis-of-erythemal-uvb-dose-received-inside-a-car-in-valencia-spain
#16
Gonzalo Gurrea Ysasi, Vicente Blanca Giménez, Juan Carlos Moreno, MªAntonia Serrano
Continuous exposures to ultraviolet radiation can lead to harmful effects on human skin. Professional drivers may spend more than 8 hours per day inside a vehicle. This paper describes an analysis of the UVER (erythemal ultraviolet radiation) received by a driver and passenger inside a vehicle. A 3-door Peugeot 206 was used for the study. VioSpor Blue Line dosimeters (with a response profile close to that of human skin) were used to measure the erythematic dose of UV radiation (able to produce erythema on human skin)...
November 22, 2017: Photochemistry and Photobiology
https://www.readbyqxmd.com/read/29164613/calmodulin-like-skin-protein-protects-against-spatial-learning-impairment-in-a-mouse-model-of-alzheimer-disease
#17
Shinya Kusakari, Mikiro Nawa, Katsuko Sudo, Masaaki Matsuoka
Humanin and calmodulin-like skin protein (CLSP) inhibits Alzheimer disease (AD)-related neuronal cell death via the heterotrimeric humanin receptor in vitro. It has been suggested that CLSP is a central agonist of the heterotrimeric humanin receptor in vivo. To investigate the role of CLSP in the AD pathogenesis in vivo, we generated mouse CLSP-1 transgenic mice, crossed them with the APPswe/PSEN1dE9 mice, a model mouse of AD, and examined the effect of CLSP overexpression on the pathological phenotype of the AD mouse model...
November 21, 2017: Journal of Neurochemistry
https://www.readbyqxmd.com/read/29164596/regulation-of-t-helper-cell-responses-during-antigen-presentation-by-norepinephrine-exposed-endothelial-cells
#18
Linghui Xu, Wanhong Ding, Lori L Stohl, Xi K Zhou, Shayan Azizi, Ethan Chuang, Jimmy Lam, John A Wagner, Richard D Granstein
Dermal blood vessels and regional lymph nodes are innervated by sympathetic nerves and, under stress, sympathetic nerves release norepinephrine (NE). Exposure of primary murine dermal microvascular endothelial cells (pDMECs) to NE followed by co-culture with Langerhans cells (LCs), responsive CD4(+) T cells and antigen resulted in modulation of CD4(+) T cell responses. NE-treatment of pDMECs induced increased production of interleukin (IL)-6 and IL-17A while downregulating interferon (IFN)-γ and IL-22 release...
November 21, 2017: Immunology
https://www.readbyqxmd.com/read/29164310/relevance-of-trpa1-and-trpm8-channels-as-vascular-sensors-of-cold-in-the-cutaneous-microvasculature
#19
REVIEW
Y Pan, D Thapa, L Baldissera, F Argunhan, A A Aubdool, S D Brain
Cold exposure is directly related to skin conditions, such as frostbite. This is due to the cold exposure inducing a vasoconstriction to reduce cutaneous blood flow and protect against heat loss. However, a long-term constriction will cause ischaemia and potentially irreversible damage. We have developed techniques to elucidate the mechanisms of the vascular cold response. We focused on two ligand-gated transient receptor potential (TRP) channels, namely, the established "cold sensors" TRP ankyrin 1 (TRPA1) and TRP melastin (TRPM8)...
November 21, 2017: Pflügers Archiv: European Journal of Physiology
https://www.readbyqxmd.com/read/29163517/prophenoloxidase-mediated-ex-vivo-immunity-to-delay-fungal-infection-after-insect-ecdysis
#20
Jie Zhang, Wuren Huang, Chuanfei Yuan, Yuzhen Lu, Bing Yang, Cheng-Yuan Wang, Peng Zhang, Leonard Dobens, Zhen Zou, Chengshu Wang, Erjun Ling
Skin immunity protects animals from airborne pathogen infection. Unlike mammals, arthropods, including insects, undergo periodic ecdysis to grow and develop. Newly molted insects emerge with unsclerotized thin cuticles but successfully escape pathogenic infections during the post-molt period. Here we show that prophenoloxidases (PPOs) in molting fluids remain bioactive on the integument and impede fungal infection after ecdysis. We found that the purified plasma PPOs or recombinant PPOs could effectively bind to fungal spores (conidia) by targeting the cell wall components chitin and β-1,3-glucan...
2017: Frontiers in Immunology
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