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https://www.readbyqxmd.com/read/29475177/impact-of-pre-procedural-dual-antiplatelet-therapy-on-periprocedural-myocardial-infarction-in-patients-undergoing-percutaneous-coronary-interventions-with-adjunctive-tirofiban
#1
Monica Verdoia, Patrizia Pergolini, Lucia Barbieri, Roberta Rolla, Matteo Nardin, Federica Negro, Harry Suryapranata, Giuseppe De Luca
BACKGROUND: Recent trials have failed to demonstrate any clinical benefit from pre-treatment with dual antiplatelet therapy (DAPT) in patients undergoing percutaneous coronary interventions, (PCI), even in the setting of acute coronary syndrome. However, suboptimal platelet inhibition during (PCI) has been shown to enhance the risk of acute ischemic complications, such as stent thrombosis and periprocedural myocardial infarction (PMI), thus raising the attention on the potential advantages of adjunctive glycoprotein IIbIIIa inhibitors to obviate to the delayed onset of action of oral antiplatelet drugs...
February 15, 2018: Thrombosis Research
https://www.readbyqxmd.com/read/29475054/intravenous-infusion-of-mesenchymal-stem-cells-reduces-epileptogenesis-in-a-rat-model-of-status-epilepticus
#2
Shinobu Fukumura, Masanori Sasaki, Yuko Kataoka-Sasaki, Shinichi Oka, Masahito Nakazaki, Hiroshi Nagahama, Tomonori Morita, Takuro Sakai, Hiroyuki Tsutsumi, Jeffery D Kocsis, Osamu Honmou
OBJECTIVE: Status epilepticus (SE) causes neuronal cell death, aberrant mossy fiber sprouting (MFS), and cognitive deteriorations. The present study tested the hypothesis that systemically infused mesenchymal stem cells (MSCs) reduce epileptogenesis by inhibiting neuronal cell death and suppressing aberrant MFS, leading to cognitive function preservation in a rat model of epilepsy. METHODS: SE was induced using the lithium-pilocarpine injection model. The seizure frequency was scored using a video-monitoring system and the Morris water maze test was carried out to evaluate cognitive function...
February 14, 2018: Epilepsy Research
https://www.readbyqxmd.com/read/29475018/kynurenine-pathway-metabolism-and-the-neurobiology-of-treatment-resistant-depression-comparison-of-multiple-ketamine-infusions-and-electroconvulsive-therapy
#3
A P Allen, M Naughton, J Dowling, A Walsh, R O'Shea, G Shorten, L Scott, D M McLoughlin, J F Cryan, G Clarke, T G Dinan
Current first-line antidepressants can take weeks or months to decrease depressive symptoms. Low dose ketamine, an N-methyl-D-aspartate (NMDA) receptor antagonist, shows potential for a more rapid antidepressant effect, with efficacy also evident in previously treatment-resistant populations. However, a greater understanding of the physiological mechanisms underlying such effects is required. We assessed the potential impact of ketamine infusion on neurobiological drivers of kynurenine pathway metabolism in major depression (HPA axis hyperactivity, inflammation) in patients with treatment-resistant depression compared to gender-matched healthy controls...
February 10, 2018: Journal of Psychiatric Research
https://www.readbyqxmd.com/read/29474792/academic-based-and-aerobic-only-movement-breaks-are-there-differential-effects-on-physical-activity-and-achievement
#4
Alicia L Fedewa, Elizabeth Fettrow, Heather Erwin, Soyeon Ahn, Minnah Farook
PURPOSE: This study investigated the academic achievement and physical activity differences between types of activity breaks implemented in elementary school classrooms. This study evaluated whether there was a difference between the impact of purely aerobic-based movement breaks and the impact of academic-based breaks on children's academic achievement outcomes. METHOD: Participants included 460 children in 3rd grade through 5th grade at 4 elementary schools. There were 176 children in the schools that engaged in academic-based breaks and 284 in the schools that engaged in aerobic-only breaks...
February 23, 2018: Research Quarterly for Exercise and Sport
https://www.readbyqxmd.com/read/29474669/treatment-and-outcome-of-congenital-nephrotic-syndrome
#5
Sandra Bérody, Laurence Heidet, Olivier Gribouval, Jérome Harambat, Patrick Niaudet, Veronique Baudouin, Justine Bacchetta, Bernard Boudaillez, Maud Dehennault, Loïc de Parscau, Olivier Dunand, Hugues Flodrops, Marc Fila, Arnaud Garnier, Ferielle Louillet, Marie-Alice Macher, Adrien May, Elodie Merieau, Françoise Monceaux, Christine Pietrement, Caroline Rousset-Rouvière, Gwenaëlle Roussey, Sophie Taque, Julie Tenenbaum, Tim Ulinski, Rachel Vieux, Ariane Zaloszyc, Vincent Morinière, Rémi Salomon, Olivia Boyer
Background: Recommendations for management of Finnish-type congenital nephrotic syndrome (CNS) followed by many teams include daily albumin infusions, early bilateral nephrectomy, dialysis and transplantation. We aimed to assess the treatment and outcome of patients with CNS in France. Methods: We conducted a nationwide retrospective study on 55 consecutive children born between 2000 and 2014 treated for non-infectious CNS. Results: The estimated cumulative incidence of CNS was 0...
February 20, 2018: Nephrology, Dialysis, Transplantation
https://www.readbyqxmd.com/read/29474534/cdkl5-protein-substitution-therapy-rescues-neurological-phenotypes-of-a-mouse-model-of-cdkl5-disorder
#6
Stefania Trazzi, Marianna De Franceschi, Claudia Fuchs, Stefano Bastianini, Rocchina Viggiano, Leonardo Lupori, Raffaele Mazziotti, Giorgio Medici, Viviana Lo Martire, Elisa Ren, Roberto Rimondini, Giovanna Zoccoli, Renata Bartesaghi, Tommaso Pizzorusso, Elisabetta Ciani
Cyclin-dependent kinase like-5 (CDKL5) disorder is a rare neurodevelopmental disease caused by mutations in the CDKL5 gene. The consequent misexpression of the CDKL5 protein in the nervous system leads to a severe phenotype characterized by intellectual disability, motor impairment, visual deficits, and early-onset epilepsy. No therapy is available for CDKL5 disorder. It has been reported that a protein transduction domain (TAT) is able to deliver macromolecules into cells and even into the brain when fused to a given protein...
February 20, 2018: Human Molecular Genetics
https://www.readbyqxmd.com/read/29474357/effects-of-flow-rate-on-the-migration-of-different-plasticizers-from-pvc-infusion-medical-devices
#7
Lise Bernard, Teuta Eljezi, Hélène Clauson, Céline Lambert, Yassine Bouattour, Philip Chennell, Bruno Pereira, Valérie Sautou
Infusion medical devices (MDs) used in hospitals are often made of plasticized polyvinylchloride (PVC). These plasticizers may leach out into infused solutions during clinical practice, especially during risk-situations, e.g multiple infusions in Intensive Care Units and thus may enter into contact with the patients. The migrability of the plasticizers is dependent of several clinical parameters such as temperature, contact time, nature of the simulant, etc… However, no data is available about the influence of the flow rate at which drug solutions are administrated...
2018: PloS One
https://www.readbyqxmd.com/read/29474202/a-decade-long-clinical-experience-on-the-prophylactic-use-of-activated-prothrombin-complex-concentrate-in-acquired-haemophilia-a-a-case-series-from-a-tertiary-care-centre
#8
Anita Árokszállási, Katalin Rázsó, Péter Ilonczai, Zsolt Oláh, Zsuzsanna Bereczky, Zoltán Boda, Ágota Schlammadinger
: In acquired haemophilia A (AHA), risk for recurrent bleeding exists until the inhibitor is detectable. Thus, patients with persisting inhibitor may benefit from prophylaxis with activated prothrombin complex concentrate (aPCC). Potential thromboembolic complications and cost are also factors to consider. Today, no high level evidence or clear recommendations are available on aPCC prophylaxis in AHA. Recently, a small prospective study demonstrated a favourable outcome with short-term, daily administered aPCC infusion...
February 22, 2018: Blood Coagulation & Fibrinolysis: An International Journal in Haemostasis and Thrombosis
https://www.readbyqxmd.com/read/29473984/dorsal-hippocampus-is-necessary-for-visual-categorization-in-rats
#9
Jangjin Kim, Leyre Castro, Edward A Wasserman, John H Freeman
The hippocampus may play a role in categorization because of the need to differentiate stimulus categories (pattern separation) and to recognize category membership of stimuli from partial information (pattern completion). We hypothesized that the hippocampus would be more crucial for categorization of low-density (few relevant features) stimuli-due to the higher demand on pattern separation and pattern completion-than for categorization of high-density (many relevant features) stimuli. Using a touchscreen apparatus, rats were trained to categorize multiple abstract stimuli into two different categories...
February 23, 2018: Hippocampus
https://www.readbyqxmd.com/read/29473705/alpha-1-antitrypsin-treatment-of-new-onset-type-1-diabetes-an-open-label-phase-i-clinical-trial-retain-to-assess-safety-and-pharmacokinetics
#10
Gordon C Weir, Mario R Ehlers, Kristina M Harris, Sai Kanaparthi, Alice Long, Deborah Phippard, Lia J Weiner, Brett Jepson, James G McNamara, Maria Koulmanda, Terry B Strom
OBJECTIVE: To determine the safety and pharmacokinetics of alpha-1 antitrypsin (AAT) in adults and children. RESEARCH DESIGN AND METHODS: Short term AAT treatment restores euglycemia in the non-obese mouse model of type 1 diabetes. A phase I multicenter study in 16 subjects with new-onset type 1 diabetes studied the safety and pharmacokinetics of Aralast NPTM (AAT). This open-label, dose-escalation study enrolled eight adults ages 16-35 and eight children ages 8-15 within 100 days of diagnosis, to receive 12 infusions of AAT: a low dose of 45 mg/kg weekly for six weeks, followed by a higher dose of 90 mg/kg for six weeks...
February 23, 2018: Pediatric Diabetes
https://www.readbyqxmd.com/read/29473701/antibody-epitope-of-human-%C3%AE-galactosidase-a-revealed-by-affinity-mass-spectrometry-a-basis-for-reversing-immunoreactivity-in-enzyme-replacement-therapy-of-fabry-s-disease
#11
Michael Przybylski
Alpha-galactosidase (αGal) is a lysosomal enzyme that hydrolyses the alphagalactosyl moiety from glycosphingo-lipids. Mutations in the αGal genes lead to defect enzyme resulting in substrate accumulation and pathophysiology. The deficiency of αGal, called Fabry's Disease (FD), belongs to the lysosomal storage diseases. Effective treatment of FD has been developed by enzyme replacement therapy (ERT) by infusion of recombinant enzyme to increase enzyme levels and reduce accumulated substrate. Immuno-reactivity and IgG antibody formation are major, therapy-limiting complications of ERT...
February 23, 2018: ChemMedChem
https://www.readbyqxmd.com/read/29473501/a-novel-finding-macrophages-involved-inflammation-participated-in-the-acute-aortic-dissection-complicated-with-acute-lung-injury
#12
Z Wu, Z Wang, P Xu, M Zhang, L Cheng, B Gong
BACKGROUND: The pathogenesis of acute aortic dissection (AAD) complicated with acute lung injury (ALI) is still not well defined. OBJECTIVE: We aim to investigate the roles of macrophages-derived matrix metalloproteinase 9 (MMP9) in the pathogenesis of AAD complicated with ALI and factors involves in the recruitment of macrophages. METHOD: This study included three parts: (i) determination of serum MMPs , AngII and MCP-1 in AAD complicated with/without ALI patients, nonruptured chronic aortic aneurysm patients or healthy volunteers using ELISA method...
February 22, 2018: Current Molecular Medicine
https://www.readbyqxmd.com/read/29473178/pas-c-platelets-contain-less-plasma-protein-lower-anti-a-and-anti-b-titers-and-decreased-hla-antibody-specificities-compared-to-plasma-platelets
#13
Stuart P Weisberg, Beth H Shaz, Gizem Tumer, Chris C Silliman, Marguerite R Kelher, Claudia S Cohn
BACKGROUND: Platelets (PLTs) collected and stored in PLT additive solution Intersol (PAS-C) are presumed to reduce recipient exposure to donor plasma components; however, the effects of PAS-C on PLT supernatant composition are poorly defined. Therefore, we compared the total protein concentration, isohemagglutinin titers, and HLA antibodies in supernatants of PAS-C PLTs to plasma PLTs. STUDY DESIGN AND METHODS: Apheresis PLTs from group O blood donors were collected into either 100% donor plasma (n = 50) or a mixture of 65% PAS-C/35% donor plasma (n = 50)...
February 22, 2018: Transfusion
https://www.readbyqxmd.com/read/29472865/intracranial-pressure-is-a-determinant-of-sympathetic-activity
#14
Eric A Schmidt, Fabien Despas, Anne Pavy-Le Traon, Zofia Czosnyka, John D Pickard, Kamal Rahmouni, Atul Pathak, Jean M Senard
Intracranial pressure (ICP) is the pressure within the cranium . ICP rise compresses brain vessels and reduces cerebral blood delivery. Massive ICP rise leads to cerebral ischemia, but it is also known to produce hypertension, bradycardia and respiratory irregularities due to a sympatho-adrenal mechanism termed Cushing response. One still unresolved question is whether the Cushing response is a non-synaptic acute brainstem ischemic mechanism or part of a larger physiological reflex for arterial blood pressure control and homeostasis regulation...
2018: Frontiers in Physiology
https://www.readbyqxmd.com/read/29472857/contributions-of-the-nucleus-accumbens-shell-in-mediating-the-enhancement-in-memory-following-noradrenergic-activation-of-either-the-amygdala-or-hippocampus
#15
Erin C Kerfoot, Cedric L Williams
The nucleus accumbens shell is a site of converging inputs during memory processing for emotional events. The accumbens receives input from the nucleus of the solitary tract (NTS) regarding changes in peripheral autonomic functioning following emotional arousal. The shell also receives input from the amygdala and hippocampus regarding affective and contextual attributes of new learning experiences. The successful encoding of affect or context is facilitated by activating noradrenergic systems in either the amygdala or hippocampus...
2018: Frontiers in Pharmacology
https://www.readbyqxmd.com/read/29472642/role-of-trace-amine-associated-receptor-1-in-nicotine-s-behavioral-and-neurochemical-effects
#16
Jian-Feng Liu, Robert Seaman, Justin N Siemian, Rohan Bhimani, Bernard Johnson, Yanan Zhang, Qing Zhu, Marius C Hoener, Jinwoo Park, David M Dietz, Jun-Xu Li
Nicotine addiction and abuse remains a global health issue. To date, the fundamental neurobiological mechanism of nicotine addiction remains incompletely understood. Trace amine-associated receptor 1 (TAAR1) is thought to directly modulate dopaminergic system and are thought to be a neural substrate underlying addictive-like behaviors. We aimed to investigate the role of TAAR1 in nicotine addictive-like behaviors. TAAR1 expression after nicotine treatment was evaluated by western blotting. c-Fos immunofluorescence and in vivo fast-scan cyclic voltammetry were used to examine the activation of brain regions and dopamine release, respectively...
February 5, 2018: Neuropsychopharmacology: Official Publication of the American College of Neuropsychopharmacology
https://www.readbyqxmd.com/read/29472509/association-between-continuous-peripheral-i-v-infusion-of-3-sodium-chloride-injection-and-phlebitis-in-adults
#17
Lina Meng, Cherwyn M Nguyen, Samit Patel, Michael Mlynash, Anna Finley Caulfield
PURPOSE: One institution's experience with use of peripheral i.v. (PIV) catheters for prolonged infusions of 3% sodium chloride injection at rates up to 100 mL/hr is described. METHODS: A prospective, observational, 13-month quality assurance project was conducted at an academic medical center to evaluate frequencies of patient and catheter phlebitis among adult inpatients who received both an infusion of 3% sodium chloride injection for a period of ≥4 hours through a dedicated PIV catheter and infusions of routine-care solutions (RCSs) through separate PIV catheters during the same hospital stay...
March 1, 2018: American Journal of Health-system Pharmacy: AJHP
https://www.readbyqxmd.com/read/29472424/pentobarbital-induced-lactic-acidosis-following-status-epilepticus-barbiturate-coma
#18
Todd Rabkin Golden, Veronika Solnicky, Rita Wadeea, Sehem Ghazala
We present a rare case of pentobarbital infusion causing propylene glycol-induced lactic acidosis, during refractory status epilepticus treatment in a 66-year-old man without seizure history.
February 22, 2018: BMJ Case Reports
https://www.readbyqxmd.com/read/29472355/use-of-thrombin-generation-assay-to-personalize-treatment-of-breakthrough-bleeds-in-a-patient-with-hemophilia-and-inhibitors-receiving-prophylaxis-with-emicizumab
#19
Yesim Dargaud, Anne Lienhart, Maissaa Janbain, Sandra LeQuellec, Nathalie Enjolras, Claude Negrier
Emicizumab is a recombinant, humanized, bispecific, monoclonal antibody that bridges activated factor IX and factor X to restore the function of deficient factor VIII. Treatment of bleeding in patients with hemophilia and inhibitors involves the use of bypassing agents (BPA).These molecules are also used for the management of breakthrough bleeds in patients on prophylaxis with emicizumab, with increased concerns about the risks of combining two procoagulant drugs. Using thrombin generation assay, we tailored the dosage of activated prothrombin complex concentrate (APCC) and successfully treated an acute spontaneous arterial bleeding in a patient on prophylaxis with emicizumab 1...
February 22, 2018: Haematologica
https://www.readbyqxmd.com/read/29472239/car-t-cell-therapies-produce-durable-remissions
#20
(no author information available yet)
Two studies reported durable long-term remissions in patients with acute lymphoblastic leukemia treated with CAR T-cell therapies. One study focused on children and young adults treated with tisagenlecleucel; the other focused on adults who received infusions of 19-28z CAR T cells.
February 22, 2018: Cancer Discovery
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